Mx3.6-1h/data/swissprot/ 3JZE.pdbdupa 1XGE.pdb-[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.8 Angstrom Resolution Crystal Structure Of Dihydroorotase (Pyrc) From Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Lt2[/h3] [p]G.Minasov, A.Halavaty, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3JZE" target="blank"]3JZE[/a] [small](deposited on 23-SEP-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1XGE.pdb3JZE a_3JZEB1  1XGE3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F 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Irٕ` 0͒G65ĎDMKo!|eD;B`A %@_kk:S}AWspn]o9Opa(ۋ/`6}GJ4$gNH$Q2V2 D:]k1jSAP=ҵ-G XuRt'%RBHII_u乤c<g4Owlj1%yϱc,o[{qȓՎn gqKĎz>4j/2#(W.n@s1 C_J 1:"OWGsK[.Ax~ Cv7x3}Gp(`)- -3#cǴCH+lHTرt.(,V6X$I %GOaa6q" UWcY}.*1F+ѩCXfFsۏƯIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0= U_UUU_ U _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ eeCj*?QQQDU֗TT֤֪ԟ֢R*EJ o#Z_BAH?ZTTQjG-'UO֪?j*?ZZ?QD?j*?AZkUW! $֨?ԏ-'KZ֪?j*?R(֤[֪֨?ԏTZOj_QQQԚU?Z֢G! $ @$!!$ @$!! ! !HHBBB HBBI*WWWf#cubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???{{$??-e7@f5@?ܱ?ܱ?ܱ??@@@x@x@ ???333333?333333???#~j????333333? 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RQ0sJNXEWWp ٱ)d !MP_] =U[֍ql^|yp,L$+Xƅ47]I,;2Z"!>ϲ~hmeARkZ|ig&bFlCOO8c;&çxx GKϹx״PL}md}Xv+`UKFa-ƚG#:}eOQ5Z@J>tH~Ua1I4UW4exb-Ģu4`otUGL"hDJydTl#  a"b:"h `q,aFFIdqRޟp'1a X M&5W|@mP0JmMҡCg@ďu 0,[MYC(F ;:`2,DzDP G]U=4 kRNUa(BASf':mǵRrTg@U-\ c!0Fp+պݼ!PMϺ %4նkbO=#tT&N25VmSު0t>Sb? OqI 4xldzL6,m#TiW] _A)m]YqDZȕ,r-GDCu؎ieе u7wߘ\K rE)%c]sX,b ף=S)ci.L<>j9H4\iePձ|pRBr0o[DZG"Q EQi=cEQAf T;̀H6_EJI&ȸ_y)"^jT /_wM7q&)IDATsSSLa??Y 5JB$,b`1ȘɷfȀO&E(h訪#9i^tMqg`9塇<ӃѵfC*QV*Ĭ6$x䈤t-Hq-Fgȯ۶mnq>cr+zLl(DSuG 8#[hUdrTQ;ƒ$ciG"El /G?뮻 ZZ&Ǜ$R:zUhY+yZEXm. B!xV4%k)%Mu??mtu pI>i8%clBACBjշi K5KSkB0yF뮝OxHԜBw_w۸ej|Hu 0`q@.ւ#ڼZDZIG;x *]BV켋Czf @x׾ƇZZG? H)@~%ǫ8Sm Ql;m"nA*鱸kœQɹ=[[|@N*XMjZK-XFxw^d߾;ŗFM+CLcYc!K8X3`dP ȏ|s 7 $e$108B 9VUwVۄm߾!>c^|M l;X\s< 7@8.Jj4-N3P( imC;LUK2bH)lt6N2=RP_I gP`.[WXȈK_ԧ&}vK_"RvUEl陦E4ԶG,YC:$MX'C('9r[ > ~z]BQZY>ϻ[Nk!!44ֶX׆spfYXd` Rz."Ig5sh| /~Q8ӗEAUyl}Nߤ`a͜bຎ/G<,t}]nXq).%kɘI2dEfB׿>z$xx/5ٻetrilloTUM>t1撅멉4i^~chº΋е !]u4Y3]riȄOMίz}zɅ^ťkp˕{ ! /2fp0ضwְ:ƕ.IeʹoLʶ sՎkJ_2 ill#w`.>_I]`Xt^F \]{hiZćox0(cR*7ЍG5bms5wPȉS8ruf` D8XCTE'=`xƻnnt@Uut;Ϗ:۷nvi_j[imZD]M#?#&v yvl={8zzM'D  Qߜ;'^VCq뭷@SuTUG*~.SyVAU|u5-4Ԏc9|VyU 'z&q4.%AU5 -H "V^p:DkS;w 7CKg?q{u@W؎9mQ2=L<5hnE#%Ʊ% scYM]1 œ "[W}Zt  hN@Ө[Axq#'!͐fֲa%vz[󁪏_ 8RAKt5@Ј 2Hdk)2wX`$nN03 l ad, 4uX+DuX5RuP[m#;pM 00rxSpD[v6}pHrMoB:"C !) EAwo ;trLy#+N[  ʌЃH ּrZr}8rcn`cґz4]G4Pr]IڶqmDzs %qz682FƣiCQTl|+d2q@E =GJn#pرYYgRx qYiBU?Ȗ㐲,2Jmb1Fzz9j8ig5/(]*Cښ{9DB變1G媒vttLy[M{rFC<ˉRk*UzI@u=b6R:KH'^^K=wSmF\uE оΒ$2Tm\c4-}ҴUkFS(B)[;o!.e:|>Lf`HhvBxe H#?ʸcò2$+o' g!pC"5HIhf=7nҪTn]6~H闓J4,~َ5gBJub¿  \ACmm+fmuP OMkWo}@/k[[QeXV}clߔgP]u!woLS Ju8 b;6^zuro[bgEAQUT]mmU tK}G+]l_#\|tML+CRJ#Q=PÅ$HtEe-y7AJcZ!lI45x5Fz87^'E1!O>t˗]8cViƕÇ$۽$?*Ųͱ}˅%c&35aCŢpÎ̫T])]*qlǓ8% 0NWXDj9oJ\=4qYش !\잱Aٙ']ρ炖%vl ߋ !MLTI5RfǵIg3/tjK)q\L6?›s#y ;?!'O$ꚑE*J0Ұ,m߈h(FI_ML+z٣c-YUK:e1n]wuQfCN߯6@)^C~ V!HGMTzjpb5-]Ǧ2~4?r{;*%V<=Ghm\JDn)ضE,Ҁ،朅Q,E'wrhkos2vgnӍ%t&QpZ;:=8Hykށڌ$ ]-+ou 7fA>=kHcl6N3 f-k'l޷#S}p֘%OW@E3/Bo6eJ+ofDuAs8|UOМu]KurՍpekcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0? UU_UWUUꪠ**_ _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ eeCj*?QQQDUҊH֢ZԚU?ZoRJJ֩UBAT֢ZR?Qi?EGQQQԚU?'EGh5Tj$֢GZUEiQQGEGjOEԟ֢UB֢GZIUS֪?j*?ZZRTփ[H$$$$!!$!$ @ HBBH@! HBBC !*WWWf#?ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???uu$??3B3@?`S?`S?`S??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3x0PNG  IHDRc IDATxy\UK{'}_ȾAvHA@`?:|qGQE Q@@ a'I:ګz~[[T%;JmsSye鼳 ;C'9ذzf6.!?q1L M I25TjGhy9 j)l" '8q#'ކiܵc:f9w;pMĒt3L4ކ-lE媍w=V?sps.6I񜈼:>p?_?ȐrWwHH\bZmaZ`5 mO$aZ:|x!lZ$޷^G esZeэ05zӗoz>rZh[ēLGэep~$%e?s #FU<(Mt SǴ t#fdэ,?sģHgc^jI(@pL$X44dIFdY LKǶ-``j|Ćmgx9DwGTZ&gÆ̜YM0.COO J.ϹY 'J]zضm[¦G%U^<?g#c_rwo[/CO "g߆6p0{ebebYm:a鎐6Qx=`%_P!|ã˸(ȔE˘7cnB}O]}%/D:6\F7rF2+M^@BEop,}jgR_=P~_x%u׹l%iD>]p{inBddI捽O#`j|2Y-am~S몦2n.:"u|-_ǂ \rOwNܒ~t(lr2[^gsyy=+HYv5@Oxx{94&z}!rzYR@Z} +0.bҤi,\X͓O.i?jt:%)xN]z)ф#Wܶ ӛh{?>o瀿Ջ/坿7mtvv/{%'(x?F$IF3F[>(89=mFx|3ggy@,E]:vRS9-W~-H^$;-͗<:2P/zK%icϱkW; g'O#dUŶ,>uGU_͟uvE3Z/B"ߎǣzTn-e7+ * QΜ'$)ȲS~:b=|o?:?UUAo`ڙ\#M/4.X@@$7@Qa#yׅk/=6dIAܙ7IzݦѴZ.Ƿ~:꯺ IhڽǏ@vPZHB [ ,b9H6o^Fcc-[sE]5^1u""#0 UEe$2MREJ,W"I J<J7e$6~t-GNqc/UJƵgWIb1?ٜƙ őlexl1|٫WSY_O@E`pI0$iQ>|:B` psI I2oΘ R /]~Kݵaٺ.Á&9m;#L"(twË/&9(ޑ&1Gv旦ca)С G[YZp2CѸm zLҗJF5- $L"^sPTEU1 ӝ?W_L=iӨ23v[yOxH]x,ʝ0 yf_Y)7^>clwo1u=ƩW]E ׋z<>sVk+/r%:O[{-Mض_3-k[ȫmmx7X@WQ^dIBV&$s^*-ȶm -LUE.lÄݔ MB+ wo۽ؽ+k_Ű#l2M\]0ummUj!6ea&3 }ڒ6\ /s~'.ila#ܾ^nDGWt)>M9VTT!2B I5%iXx{ ,KϺ ge^yq5 Sπ:&xZDTYAH`ےY!lUяW:b7x殡o??,rc2LY6 M7U<)S 0ˊREsƊ+ A<6ȟ6I3zwu${q{pQrqAp 7pàbδ?|xC]`[֐e<%ښ=u)>O PEUUg⋄$;QB'훥a:R(w-x?g14=xߠ8[pR=j` '<%yL²Sd4DzUmTVQUrևC3N60Sۂ#K,s<<8 w׾Ƈ?ܗ..v5lo$;2PNO^$=Aj*9ܹ/ ,!$Ir*hj9Sիyַm[o6m*UW]?pQ5=ӀӁ'TS%s/\{JVXnVguy'>Ag#.Eli2s,Y{Jna0Y  6>o'R6Sg-<w yŋYshѰ _E/[;X?xM TTqΚ>xa6r'*$)|JI$~ۮF^8w1q.(pVt̞ͽ['e]jH}a<g"ck /;F|஻:( eukO[>R^{ӓh'&9{l\7:|b,}<~qL,MLEQYf d3~uz֬Y\0wY~=se֬Y֪  kp\yk#! x}AT KQ<Ȓijxuot '^xQYv-W]u3&ua+dTF&ģxz'29SiLum۶x"1< 몜 pܣlذUV3zOKO# ;bv qTh~~`gmBmMT cTG v"}_⩝uݙ# obÝ4ĴtR^~c{R<$ |8lEӿ|]ڍ4vgݭ4S^dI!kB_mk# ׿$~1ZC ؽ~Z3.(]6,WKμ)x}MϐRhzMb9| uUS4pEe{g&KR}[Y&o13g䓟d Q:uGyXm[ \"Lpwr63xJ۷AHx p-0n.GO բYb P SUр"=ϊ\; ˘3gwגh 1{27%C/[8\"gx+{DQTY2\mXn4m=^Kc9tS7[0s 3&/f&L_=U pm.#& S[54DŰXYeF>xݿ?^^_Ta(]]]8[=P#M~,IXuLĴ -myܼͷ{,In,ᜎSSG,]mUZH) O^Dfuj'E0tיLH#_y.EV@3.7Y7k:qЇ>D[*ՕzS=$S=nm"EQQe%ˎc;9=`fp2-3wJ6̧fՖ K&:yA>pWei#Iaׁ}d7;ڲM#i)t3o| CʵSAUdwĭ mH$'$+IDa0ƾC2ɽt 3/j͌ɋ¦7юW3v^+ s٭, :m٦+#4#Cs.:F\zV*-8Ө˨攋 $g'~p$g(yBĝmAp_)[PHD4DV;fƩK/ö-t#K2%%K8™y4?R?EV{ep٨4=[:M_xnJRg1DzxݱzbR@Uz# x=CinE4ކfd8wcZldt&FS뛴v+m >"A4Ng)sqFO9m|{? ,;I@7J#Ȣ |*ɛE]4ztZuEH,u*~_74l^"o@zbds)N[T6FFKr1mٲG).W]CMd2қw?\KEC ȔH<G%͊1@oԑe$zcJ9^V,H8Tm[q;Dcm%FiP$=H%PTϸT3JbցP>x78ܱab.rZ IecucKyvԣ**k)Y@%Ŷm9|iQAHfEHl\R%*$I" s9<r~uM|K7a $ O^JI!=c{3IDATn%KD"l顶&V? bW e-xƊ+dSdrI[k"xT/mo-Yát)s]sಳ>d M˖] 6 T"I2~>1/NB\ٸv+9#K0&e -]ݒ2\GӳoJZw1Tp6u 0<#OMT$I04Ą"2;@UfYںhn+]ZՋ/qw陒;9-8$ qN2 uV,؀x)XY3oO,}8Z\yeӱf !hڇai4o'hGO=";.v0/ՑɜE9s>:17=cHDGں苓s?ZZ=b<1J윲$D*+Zxu^R=@ faOvN[۶{{9^}b@^l3$o*+X˰Yx=~t=c*E9h`5LP5 R47rh4divCJYZ\x<> K'`T3r 'lC8!¢MP{Cqb[P$YFؖs1y1#԰E+uK.Ŷm S#=E.QU7V':VHoX[;V]Gςkl npA}N^OH &@vaҘnAA|]Nn5\,g4nZkW4~;U6 RRmX76\; y̟_uΕcD\;}'#Xߚ6i>S̯Ԍ*R:G9JY^W_J<=ybhH#Uv񹐘;}%szQE% gRLTŃBt3ĊDvz-54M"e[o)Hx Cjr :B&$&g0M :e3SɒR\MM-'M%-oFNYHW$xӖsIRlX{Ŏ/G I2vr ƊJBqN{4'J{X﬩K YVzacZ<F>e2a>~_dX1M6:{ZblF'|ړ!+0tkHfzv0stpWIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0= UUUU_U_ U OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ eeCj*?QQQDU֗TT֤֪*EOTQ'jU_! $EGj*?(#UZTUIUSRT*PEHAZkUW! $֨?ԏ-'KZ֪?j*?R(֤[֪֨?ԏTZOj_QQQԚU?Z֢G! $ @$!!$ @$!! ! !HHBBB HBBI*WWWf#'ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???u|u$??1E 6@?@G?@G?@G??@@@x@x@ ???333333?333333???#~j????333333? 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w %J5t 9mAqt8d!Β9k'ڄ0!eSUuqp:<-}-i/Pez -o|0v>Ӳn 2ZbT„geH.TԚGYH6l8TJ:4 SDev5 :ј4KV'ӪDX&o=uj#Ia:i6('3N[A*ʫ0-x"B8ҏf fQ9xleƤ"(*eC Ϛ$  Msp]B]m=xPP2 $TuPGu7 <N AUMQ41, zi~Xbj# +W*J\N/,ĤUz/U)t5AUTYŲ?MOi #C,`GƪQ]UK$!/A_xxh2 LIq9Þ7Q= YVPeG6OBH&#AzCFV٨ DeIa֭-&ms4&f$\|UU$ "}ᶼ` `n </d2N$7NO0Ixi,&h4=Ɋ,PI:"nvr<LSG74Ux@=`ɲJ*,fs2Q@3atu{p98k8v SCN)_/>"y;ڪ\/_iA9eHēQn:{^)ǯMOP]>5f/.4=M:'h)4=eN*W_1/{F$ϼ+AuT^.xWUQW~ՒkͲ|D`梴=f.wEV}6^^w! _eLt&NJKi) SǴljS<9VPB3yeHu )R[9@-d?VqA]U_?uǂU/( TX2B(EoAC"\.Qb.H`:i-N&$', EVP$9UeIb!3 Zt&AFO_? *g2~!^005(DGv$üXI"A74dIBU|ߣ/Ư06앋.trISa8hl+K-Gj!!K*O9^O<#9kLв&I=f4xx;5ӳ%RH pq9=^n<\%' @StBUͣz7\W\:pL  $&t4rC EQ%DAb ҙ%l,)ܻؽsM,9vSv cZ^HgOqnN5ӹ/=*#' $s65 ,3nu3/sӖg*LHS!rWx+Pdf"SaQ;c%r6kDʽ&lBѩIWϒ,@75ӑyyDQ<pp s_2;l~CKǞQ|燯ɹj%dC K{5tC#'Hg95|&N_ mysL^3i:[]piPzot $dh"SuTݹ YV{+QN*@ N_x$!K AH 04z?ܑkglEVE{h7"q X4+jgF.G4u 04t#g 0~!`:Xwщd-6őymY{ ±^n2Zۯ*}caT/}85G"" Khx璳o#DU±^6Zi_%D'O6Eat޹ X7Hk9r#ErzOx޼9H{O#Td&bMSk*i-AwHOq,7&Z2g-ʼn-Udغd_"&2M>q^D Ӌ9itC#롳=D}Ȓ̍H;ȲJ$+~]GUukP x25d fL$K0I0ډ$'7NOW80M-o3,)ٓ]MjhTO0~(J2ts+uȒj(qQB&{H-,%ͩK\ {+PG6e(f/Dd7 u#e|Pډ'C|rwy_{ %; zضlpc ,ZNe wTyL yC(K(ڍaj̞KU/EMO96v>dWRzrCoKiGO Dŧoi×(Gϋw6$+NkPUX _ &I` >wDj .bAFEYQ1-suj\ zhagAKUSh)>~p YV"SN>X:\<.iic?Z=8n{,PIIeKH"Tꨩ|'熑)5slѨNa"'؅^ VK*JeUu K .x2L([KW wsyaq+UPXBnrxQd4w?9Δ٘Q̹\X⪜azeImHyg0{+9Ew杇@$RNzS(\CŒzÈY4{/@伶uCC'?dRyi4@kx,$IW< ʲ8Tg.$[Ȳ] 2z {o=_`kK$fZ| >Oh zi#ǙLB33I"^Z^7_؜y$ Ip V??0pĎ' E%, &Lg"`m!-ƱɂC؝P_=T:I(]?w$wN$bWcaj#s\$t~|_4{ NHk^|)^$Ed K9MF? jߍ8r>b0&P7\b` @֒' x@ _0@ 4TEVvtY:w- !e`CB<.baՒKpf5ҙĨ02z,Q{ _hZQTLaO~lXvո]>L$w^"R$ZdZ$dYUV{j<Z3Ín Rsy֮*7D RnHJBʼn1ǚ Kt=A,Í )-1dW:IVG{rHGrB^ӮB"aJ$lIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0= UWUUWUUPUUUTUUUUPUUUTUUU_ _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIJ*#("ZkUW! $֨?ԏ-'KZ֪?j*?R(֤[֪֨?ԏTZOj_QQQԚU?Z֢G! $ @$!!$ @$!! ! !HHBBB HBBI*WWWf#_?ꪪubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???vv$??0@+hP@?Ǵ?Ǵ?Ǵ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 51PNG  IHDRc IDATx{|UmO2M+--^EZDD,O]eQ;+eA -6 Id.<$i4I2e29yt>=| 80n9^5@4\C$XƖcƅk`:=fۦC3n9x)/e[؎#K De&mMQqk+LT/M_.Ho~?"{{*"Hq\Z2I_}B$?`}U 85)/%/ţxzk&dy,-$3..#LRZ?^4q F Q2-ؖ?{g4 l²,,DN&QTYUSI'EI֏03,y*C{VFemzX @_`9`9@0q؎Dt_nR]|yb&ax(E< ЪiO~e"ߏmY(NRA4 LMHk !%Um3qq,3m,4 Lȯ- "r(O/dpSN{v4>9>0 a!8:U00V@, 8N~#[K * :2L]_bcjmYqppp2l2,tH9UQCSH-Loʲ|jI҄I k(ēe+|YQ% QD$Q"%ӓNӝNc:Q.sSYnI&$t4uDAĴulƴLL+iF0-ǴIiqJBD<# `;63WmNMo-Ii =̾p [vCh^FȮo Χ*@Et6G@,c~O*Ow_+;*,8keQZa3۶l#ا0GbҋSVZeY^6m&> EQTZOflӨ.G4RMYI ms÷>oYBRTՇILIt[_ ~7ԭ@YŶM,ƶ͉LN_E4RC4RCyi- ~ }:"/ i8D/dp>(J$ض}zE 80Y(+q"UTנiw&߻/~>MC; ƇMg@yiSA@eك"{l'oP̪\犎< 5K( US.gv\"(iM{~Qϥ$!RRQiVzbnFߌ q6I- r7/ًHYEP e7/N0n%`HZJ"VHh -!2^Ջ~ S޾n:L_Xfmz[. 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Wb;Vj\|p rO41Y `# Cz=IR)µ󺪲9Tq!hl`FE1[%֝3o>:ȑ椓 <#8ch VeT8u4,l=Ž|/2&qU^3)3w֩%$R}<ԝcd_=pll@u@<@i:U SYڕx(s]| w/wy5wgc|G+.-*0ә$ebf>oibKcՇEADW}Fלkhz*q Uۼյ<9+DN%o`3ؿss 7>՘}Wrݚ `4qxi1cıxdEq`n=h_,Kf r0Crzm%fk 8/8;} +VG5<U]桇no.W\aȒn`1cl0΄P .P>Ȗxp`xş j%bCˎ4GWԅga&6kX3;mq\x`l@glX}%㸹ގ=Ȅ4 p`̑ VM0e4d?\JըQ Q;'vOj`;N>ls JWcnh 2L i<01c%ٚp͘uO*_E yu4:rw$r D{zbmg.yl +6cY.I\w_:AIJL2z -7$תi٢Aɘ;ƶ36Kp$r%k@EdEO0Zce"1k)Q1M- qŵK+~6ruA˶K̘;F?I`֤kk^ɖ%gw֋<TVќ~ \4>ÄJ ϸY`zxoGuӜ؎_.q j{G$)3XWIŝGGmԲ}܎Ǐ}cl^~ӟJOj$OvsVa]?o>@9kyl&d:."?(ɳnf$Q&c' ^M8OMؖ-[?< .a롗`zffCmŸ'MfxH{mx?wͥ^_Oyy9`|"8ݯ?GOhh$&Ƙs Kkqˎ C駼 òMШmEԧ3 6lp8L&=وϧ0{v IWyFdY 6l@?[_PUQd*jpLʕXYT/m٦FQM[*1ƱпoVvA,[ow1\ߍm;. RWW&{A8 s P]]=3Es֐hz|蝷sׯ;yc&VV)@QY%*>4=;/QSgQWWJ$7,w~y~SEyg.N:1{ԯ@x͓ںnش koyx))-?glPeYgm" "meói"wϢز.g)/5! 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HBBC !*WWWf#_'ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???prjp$??@5@ yVQ@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7+PNG  IHDRc IDATxy$eqUY]}@70@#B# .:Ύ~Ϭ:: :≂0j#^4MU]U]uqYUՕYUȈx>>rifٺ ' aEK2ڈDdϗwl%V0B|矙QU:ꪛA#p@mb;֬ϙ`ik\iؖ P R8Y3UޖЃʶ /PzX~L6X|4շMxN3"d?8VB8EEAQy#Sǰm].x팮5EQB,lXy ZݖLLjy? 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O F)=,k]eeYѱh~+mlwؒ U $ sx]^ȇav4ַ:#cƆHF9=Upc86W^RCI8e:S;^uۤ&1R8c[nS^ yUQUIEQQ="Mv~dXѱ47O28DZ&ȯ*c;N;kZ24(P)O>M2GU4 cK#lꮩZ9?+("e)|WI%Jgi:֮̊+}&=_@{*\ifgt]{*z4 ؾ2$lb6. $YT<ЋO ˗ܫ>y MtֵWPS]ϱG9ͱ禽fo[XI ,o<k"˩?5 B$СOW'^xrYmi%Pё11t=ֵW`B(``8.$qYa4viI' ]v0 yq/}؎&ᕗUֳfZzO +k? >4hOOz7KZWЃ&!Mb&cc9&(O7tXt$E S5!DZ ]3~+ ?= .r;t<}7lp$WEζ* kE=3PtuLTHPt2GͶccW@DZEv~6QS[S{cQ>'L_T9laZ٨ ٶDzPja˽T<<MctvDu۷=fwC*~?M8Wob\^-S1|Xbd2_,ccۖ'^qQTCGѧxBpw`;]^AnIyTQ7xkNd%ʽ8SW*RE,>́Os^ˊPJb86m* jU*Dz,,0 Ҧ'%N_?AF cry4t"C@7ݧ3~\R0O8ma{Y";d)nE^A8Ŷ-SC *BHc쵗}$YXE8T5ݛE׶ĤOA9w**lt?L'y\]vL۶ie1,KZWWb1Q>U(א1SdLxjdrn>z[&0 ]P_iP](pmYR9MҌɅOX\nyݙyٟaZiW;&:Z5?E@TDzM 뀹^s_t,ʹ+tO߸j >DmH8J0XnY3E֔JpLJ#% B(( |#fBdtM'ȼ4@ikkfY0S[~K \#5A3 L+FΜIմ2^] =@a;6T˰0}'$"?a2؎ͮ◿%vMd.q8˜qEQHF,P9W u.tW]W)a{'βwC]tH%߼.l08xbw.&=/O.8;ᙟPʀ=ָ"mC}ꅇ,qEo.zr:6 P+Naᠪ:җƞ2SxiܛF^Dj 飂BdaI?Hcy;ZW~p~Pn;>G8{q"a46@4R[654ayEK=_y=Sү~v-)Ӽr?g Q/Of0-?hdj` ̫^zKY86‘eew>rLvIhM2Tmw@+{w㪫轂H oSP4ꖔ%xN*'1zPf%@S=h" eYQ*R8;.UW]ő#G&"~\L)-[:p)RĉSK 5%<x=+QϊlM"5 FAͲ-)<[0 "#ףr!K%PcmGٿG<9L6²M^wuh3*w] X9TjNؤ@fQw@zM￟M6I}MrτW\lS6Xs6.n$hL&xp*6Qc8Lu޴ʍZL޲wbH!.Xq,Ʒs'$I8ir7~eIt͐Ik \7ım-T=_NAx_.H!dl2h^Mu9YN K) NEjE!s]wQSS}@3Lz1Z>ּ}<o?~YdrIIUUt6NMU C'*ҁ3E.A>еqե$S' Ny;__'>v˒dh^@Mֲ|Cwc9&c=u.7UJGZMMɟq%R*i9!u0P:0~c N?xS3 ͼ$_'m+]Boÿ+wmi[*{;B)OT,w*GDjށ܅dzL1߅"2Kpz8}CLj%0 \]z'/h&G(wdy{QRyz^%&/#m2Bh4Զ|(7紜˴ ꪛ6rݎ0 ߿t1o:(^TUeI:B9g%gaE?jHeb%o,B#W&AU5WRi5dAڛW5e*KZLY6|;{ؾ};`'yPl 2+G4S̀UFAHV/m]&TVbq5p/.ɯw8hͦtJ`?ʫ$u3nQI7YSu7FfTζn9Y{v`EtgB ^JW{衇w}eLDjXbt6A2#k ҙ$LRX躆4ۿܱ;A ^gV6ɳz6fd:|zTm:!C}k+ O㎂_D"Uw__DhM cʮBζ2n^FtSsy#:CCCtuu/[aooD"ɓ'ʉ𓟼V~oZ[/̚71{wµ(^̻ma;&msd&yC`AFᓲ+Ba-<|T, _=ɋThX`8 "- mt=71,FBB?G8%y'״1V{jy_̸/~;}{'|˖-lݺkgC6%TmT&ΡO͸ M˗ Uu)M8/WYg]2kNhK}H0Ÿf8}.Mҍ7wOcx#|+k,o|n OEBrF3>ˈى ah& MAgƶ,L1*ҟDz- ۏ IDAT4kfy,5dh_VX^Qh^]1볇 6PUW]u 7.#I*5F4]uP59AFuTUtMPu=7ReM3< | Typ+9|4O Ome2X>?KNr/kI>I)ɾ2MN^\ң$O0z=U|'Kd󑋴'`nPOQ 9cۘiX:EQQE.+[ˢ኶Sil Qldrt47r deff2K fKr:\q7|Ť%&,`pt(UWg $8\<8HFR3-MMᓣ <=l]?}$ZUM:ώ [unmiJ[؁ 56VpM3({*^(3D f`gimFQIt]h>&MMζ xVfEQ+n:V>{5fIJ:JT$ȐQT%hirlFm}f:,l#XۑV_x=t5UeX5Ø q|]g_d^ǃ=I=5r0%| p+QL6m[4v D*Zҧn+7oo_/xߗs1ի[ؼy)?^RL@IEykrV F$TcTvqV(gjǎb~vQxj":B{ӪJwFrickB3&ɓ#d)zzFعsW o k[J \yzPc;)ANM2T<%h]]ttԲre,ˀF@s!]K *JXQҙ 1d:~ M3l]7y4r?W5q,P+XUR JMS)/!biy#7 U[ȕV4FfyL#3͗G#u~r,l_'8^o,رc%XVl"sET*BIHJH-H29v)bJc|;wK#48rt'Dه-/,kF8'?kP2y$qf_Z/Ĝ:@(AU5TU] 9Gٺޟ=fu EDUTVtls8˃h٦̙h6&ZpOI5IENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0= UUU_ U _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! EGE֤Qi?Z_TQQQZH*#TQIj*?AU_ ! j*?QQQDꨴU?QQj֢5'EGTG! $ @$!!$ @$!! ! !HHBBB HBBI*WWWf#_L ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???oo$??@@A?Q@?2?2?2??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8S*PNG  IHDRc IDATxy\W}?u[RwkX,yc&d209a`$p&ÖYۉYwٖ%[V/]]]Uo?ޫݒzQ{zu}E爕.DU4 =F[S ESu葿#j$ t=vM y'@H7KFh*5LD8syeU蚁(ye8<<M '|l,%ҜkOp 5#DY ]eIƛH'HsShe =ʋusFz.;#yjǑER9r_ycPjp/}FKyFdž(WF!%f6V/Xõœ04r\ )$kt5Ehq"zBqBq o%MK6tUBU5RJb$X3 Xl3udhͤdSDb*u g V^ BKIWmuxx|i82KID3S9\JsH}3뺶d+T+ = ~ac W*y<<|7o熎sISxX4i>+;6yR(;lC:b]vt-B6lj tA"ͽnXfEވO4"$j\\p _&J<&K)/kyaƒu;I4eډ)t-ʉWß1M]lU%s7\iy.ckvExx>PUfRJ.‰wx*,ꌕ VEHsZaOlpT\w9ݝ7ċ?TEC*RQLr ڧ$Rh kggBumlulJkbz.W~qMc9ֿDxԩzd'=^gU $ {wTѓuL(cZ!ס\CSu =ʅk{~q̈́9>pqؚ<{V/ UUߠ)dSmu>uCJ: kcYeJ8>pkt6}|>y96]1XN˩Gֵ/Eעwz]dQUbEIƳ|6d4WԈkƥUWe*6G t{ݦ. Tԗ3!?҇eWl3pC9?B2{~g=CπRq}>Xy9²+ >JDݕIHs>"zUTg{ߐM-l!DW#\ZvrTD

z,?t|Jw]sj?n'j#jôXZfq&?}>AЏ-]ll׆:IgBaٕtr6N{^FF(WF}fd8ڎel_r!=[uk; 'G+H߿jޏX89k%ECJU=u`;c=4R^FGy,tLum 67ؕ@U\`iz/I#؎9k/]!jއBbeJB+7xj\V2{?h?þ])il@d+\<<aFF12]hwKѱ|(}^kއ8:P#ǦR)r7>W '@O>NSFJm7L’puءT>Al*zߪe[tw>yI*V EQsip\ ޠ UFS T^=b=n1v=>v6:S MIq#-٫ȦP-ŶwT˗C({?; JYƶ95C!bq|SRmBBZ!Kɦ5"IxMa _ӬMGVkuo% !sU _*{U mkTߪGx‘`_WI=ÔJww=~oO͞={?X;h<|%ımˢdMRbBɲ0Oa£}h]%ֵn+Npu RPO}. d"h0P 0PT((*.u:4 >?⚍WrlBv~,TXiî 4@ez@ (SɸD928U6'xEhWOWrgξݴrglox߶ibW*XmYRTpL36ϳ}C(q$e[<!}79exx< ؀ ,rTn_ |!#o2>xm!%RQPuݷ.zh ÷yKr.n $rg&re's|XH[3 <6͐ mxk7mk@ ` ;v@s",, :N=3`~<嬟]Q,;w*w9ӳya_p|7 F+R:Oyt xB$"خ:u]'RrGD幁anumm)>_4F;>o38O=EVy4Y| ' 7\׭=y>=~6#ӹdm5#vC7ʏ"{^<'[^\9J6Gc6(oB'Ţ 's<#X=,=Bg)e|Bmެi׿׸ ɦ&XG/cC"Joozu'3p872A5%Oh1&0y E&%"pMkx_'?ٰ>Z$=w8|' 5XiHAm׬4J5%Oϲ<ĺ "X!M&Oaܸ^)vb)ؿJ'% O.OI?/KIc𶷽c^/+*\]W-e&^V8ZlfG e=CQlY𼆺^|hX󅪂[uX*"Dω8H \/T* 5*Ĺgq,z).3g˰, 2/n6è) -]00+u$mQ^AoBᕀ@n@0#y^f<<Ckn}vM5fʧ7)_ϩ;4M,<~gB wצȂFidx6XQ@*פJ :nM]tFy w_ҁi.uy8F )DPE̺~vuN;F6{w\@\FcU/xo<~k{ eK9i%VݮJ*׶M)0~@kn9z_k#xR*y~JoC @ t]G4t]~1pImwz>Vm ?&}PnPI N>N. 7RJڛdLJIU WB=yBbIk&T O'x㦛n/3^clV >$q g";\u@a0R0}\FP%Po7qJ t,%OK3Xҹ?Eث[pgڵ:tgiJ/EUu<ϥO6s֧ٙ7sBT4?g^ n``4d;XwƆgެhZs+&;կ]O7xiw 4I\T[ IDAT*166i˶mۦ]Q#oyR{Džؾ}o|~W'F΄ R6SG=MDi 'P y&1tZ}/| ߚ["`?tBӟ ]{zf=]]tvYw%?x=w0f=18IQ#AR8y] غ9-{*5~6v~(]kWÍ-eĚXA?۶ѹ/x/[)M͚5siNX:w& NK}Ӗ zdطoǁzAy- ض;s#.U9r^׏Iv:ΫN v5A<o|!qCSo4kد9=Tꞎ<_46VWW<yv0\Koo//Mw+Y$w{֭[֭H"6wrw(7>|%F&8pTţi$he`8 \q twwwY!G` |{N.Oٔ^J&hIz׈nfsŊ&RvoPe˲,_C`<Ydh1!LF2=~R>HrGѵVr}?o;Ό/_}74_ۧ9ۉFh#X?Dz+ nTUsb;z4֭8|pg`yƭM5+GFI%2 l$$ Ec˚ߦb}pv6nHPছndgqqROڗ4S5UC i1 c0lvؕ+O|>oJZ-fHhО12͓N4#BH5hhʳ{~:.[l<0͛?tȑY1Q#A6x9a-|+p,_%XEfM]{Yrc8fB:тE "FUтԷ4>.j$IƳV|aff*|37qEN>j6 .3uufm&ǐBb1Ӊf@1D8CTA $QHkPW .ٙ%/iR ֯u!cV1(B*D14rbV'bѵT}I$$(zj7]G<v"K,Z($uJӶsbVqb~9wqJ4HY׵(Hj8.1oy,ŒcpNUzCף"eLK]HD,ygo;[$RiJ\Dc1-yFT  "Li$q \ǔhεW'OZ"HkC޾w5đ#g{8>?yrq*)qgÔT(ǿyjƷ/D[E| :"",g^N„aq`1Δ-6Q(Z/yQL(Pڛ|ɳWeC>cR(X` NY-@:@R`r]'v׵?IXzK.Dx{+FXZxGu@#z!5ސ(yQU%B`rZWA ·4bakTp=GgI ᮋ-Blо6*+5sP=\i՛< :VIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0; UUW _⪪eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! EGE֤Qi?Z_TQQQZQD'U$EGE֤UTEGZ֤֪ԟT("ZBAHHBBB HBB @$!!$ @$!! !*WWf#_'*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???nm$??@1<@g3@u6@?y1?y1?y1??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9(PNG  IHDRc IDATxy\W}?Wkw-ue%R [ c 㓁d̐! 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""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0; UUUUAUUUPUUUUUAUUUPUUUU _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT eeCj*?QQQDU֗TT֤֪TQIj*?AZkUWH! QQZj#HUE֪GEGRkUTT(IQQZ o#Z ! EGE֤Qi?Z_TQQQZQD'U$EGE֤UTEGZ֤֪ԟR? ! $$!! !$!! HII BB HBBH*W#_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???uu$??$? @?`а?`а?`а??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1030PNG  IHDRc IDATx{|Tչ{L!!/ p@@XWQֶ}{ھVmֶcO=-,VD.5r$sݗL2L撫O|ff7kyd-BG'A4d3$yI /|\$CW,InA-tPTGNaHP>8B:BiV6@:B7ոi" #bwqIX,\f%#@z(:m'1! 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""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0A U_UUUUUUUUUUUU꪿* * W ? eeCj*?QQQDU֗*֢T"US?EGh5JEJUR*BAT֢ZR?Qi?EGQQQԚU?'EGh5Tj$֢GZUEiQQGEGjOEԟ֢UB֢GZIUS֪?j*?ZZRTփ[H$$$$!!$!$ @ HBBH@! HBBC !*WfW#I?_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@??? $??}j5n/@?`x?`x?`x??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11CPNG  IHDRc IDATxw[ՙhzǽwdK %eIBްl6mلe7a.aRH$ H zlxl=K{fFiF珬S{$@pcv6$*iXiaDHHHL<.Y뫧*g ԕa>~o@#e* dIF7aKFD%Bt-m3 S I2e`ZPu]>$IBB"EKϊ:]}mOm,)TW4vPI=N4$#:?09i(P$kDY!a !I=Ƴo}R7I)}0ubФw|Tw#V>TW4qa}rZ?nťэ$wߤ?³j(İTHH,IHH>,IF{+K2®ҮI7P+93:Ĝ?xx?? .Ճ,+H,5Shz`ǸeYqN &6a7}3jd7h !,,!>$F|Hryqn<..Hg _s6̟q,0i1nz] +CBEV/t4/얯\xM4̠_}Qe[,WO#GUݬYr.npl2K d S2 L25.]-cS0o*,$W@ K6ŲL:M e?AڙV{*]f.e(r1"$.]?_}>mU5R=*)W*rz p{%ac: zCOB ; =֩MaQB`OuUX⵭ɟ>.L[Nme3RY^ssuTq%MsL-K23Eǃ>yꪚeۏS[[-@ӓhz'FzK֏3V#ve"P娪us9e >o9>rSQuYԕ)QdbuLkX̩y|HIXS9ZU!01 pmBR72%,|ɜl:3Ec/S~n^kkezb.?xKESY^`p·c];N7a>s-ť'f7/wtPS:[|7{bTYRZV {yk&ՏsQ_=`i i}^CuL]V^7޸SA=(-nA  PU^O(OeI0uspos0u4#I]T^Nv@X5B`&X˱D¶PBUQ'c#}x=eחeNr,O|1Mx2nhޕuё';I0L.9K u7tP7dբY V.<7IRyᝇGoi{Ѝ$gjLY)Ȳ^(/ eh#O^;gx\`yuE¥SKlH ½ܑUi]%, SC\vΗy2/ #I2xeOAaOz"“9DP?. nǿ@ VMEݸTz Y:D`;Y¶Yolb2Hh1Zb㙐eIZ^$)DC u I6Fڙ“ @$1Ͻ'H}+P7vyX<{-CXFydT]+,$le *30FPGRH9б={E>2o%.]vx=!,ڸu fOaɟ%'.a:e"$ItmmQh@75<.s"}d{f3^ERb 0PJ@$iܭq kkĴ=vT$v$7޳=5n ۇK²L4=ɞ&.B@oэA$]v| a7Diu P=),N_{%hZRTaZ!,yΉykScSQVǴ(iQ[HAs@b-U &nمajcFs$ OV.8Gq޿[ +jwsv.Mu@=H.]Ou j<஻Bqߏ'ć'cxe! 8ꫯ~_r%gDx2Kuģq1eʔbr_ pΆYGg\x !α,Ox]>=Db4L*YGgh %,Եp\.c߫P28DtTxKE~oˋ8aNwAcg8*<㠧'~{HM]dij<.ި{.zIj X;jO]{1kIZ2&$akQ:z2~.⦡z:|'EQrY!j[mG )q|ýThɻy8iꪦbx=4VpR#qrwp3=zS$d2+!mٗ?~j|TMa͒=73X(e#`w@vS#C=6+@EVXu rȮCĵ(T7ω7|;~gXeGLd NCo< L4M Ӱyuԓ$(bP[97#DbCXEMecr~v>qG}_2Y\sp)hZ Žo'´ڌ:es+:v:L6NSR{޽5w+lM*nEŞ Lphm2kzM2.9Rn'Q,TOA ad ;o*ܪO߹I+w9]].M\۴m FdݐPP:KN,ц4=%QJrX8L&je9m^(faZOqOk\KuOIMUqu9J4B>$Y.1 KX95 9A>`a`)ʮn~K>6a˓=Z²i L=yd9Y ꪚ1 mTt&$N2'Kãm gһ* yL6%\$68fbqc;&x~{\Q\q> \pr֯ Wu^93v )3˲9˲s @EkVNO"o08<RiYnKeO` IRrb;" ~O ʖ5NMM <\rɨBdzr/~;0ٴi!.Lur1sN d$Z_"(d&cakDA^z7c9cUʫ%p/=iP9cw%D=to#@eT%Z` ?d6Kn Q(֯IX=lƌܹk9)sHxm~16nHlK{ @g g4,9iHs tNt:{}KNgU VcMD5g8S_~9B(R0-{j)2S{VN-(]1{h3Kuj+{|j_{.B.B}9O%Ώ?.B5=A(ҏKPY^G86H%,Z;'anV|5|~1s# S9Թ-l) CQ\ hFaQ˛\B?k! 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JlO-n/'y'"K2etZ04LL?0u !?Y'^JfuXez` =M UuR$(`OJp|iIE<Kn$Z^2,tg:Y[6n'bHJǒa1miCpOUmv}ᬵtVq2au=\"+$}:⚰ЍD"B4J_`!, SN(2hb;x( =I-N(:0Uhz^FQ0eXOiF9}ng4-37x e彰l#l*,%e uSۚ'^ -^e6A86@ j#!mRX䙦>LiOJp$ %kw8l!zԈھ!8m3!+ʊH$w؀N꽔"ԶXo&Ijq6n($S LOdOiBŅ+UEgwwyTs"^ ^ޜ;@m8عH*ij{RM6$aYRpPG8Ve2F훙;}%PQ56!D hi^ YVYd#oN0!0`יdcd="' +wxeӔHhQ@z4JaOq^G*@mTꫧ -ddIEq:( K'i,G;6FU ?>Ehmߌf$%œzܥGmxm72y w)W1rx.ήGuO#.rӾڤܩcD Iu8LKayFNK)!J¿iyͻe{+Ȳ-%$IW(SK<7㦓?5ʊDkf Әc]>,w߱vY9cmqd%,$!BvdveUOzz:V+$nƆK N@Slr1>,LV'K{ft#IEY&rt#E j>БgSᾲwE?qB[JG ygi={f>e2P6MN;pZ\^Ӑ@gOXqAѝ)j+,;eerJسhm {nfWf0Y~ԥ#ְyH%,Fĺ ԙ޸0|o$+I.`&2_0x_O.q|[Do|{=Zѩ fLYlR3qH:0 &fָ @:|َLP8e) 5M¤w`95=*]^NX0%o{"x=LoZČ̘bgG:\o*L74,aYŊŴƅví4z%hnț'Pv\so>8xI1^IgZ{vefLYBbټtIA7ϟՙmӠ=LoE>{7" fM]^ !&@4u')M02-Va‰kqK}us:eN#k*Јf$8й}OU&"!*j(8t匿?˴fF֗'™kr ` Uqji<ϋoT%CLNp5.t,"g]'.WMO8B hIOcKIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE 0 0H UUUUꪪUU_UU_ JU ?_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTCCCeeCj*?JTQR?-'(KZ֪?j*?RkUTR/RRZkUWH! QQZj#HUE֪GEGRkUTԟR5BZTTQjGUEGU?GRZkUWBAH?ZTTQjG-'UOTZjMjIQQZ o#B$$$!!$!$ @$!!$ @$!! !*WWf#O3? ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???twot$??FpDj4E@?ժ?ժ?ժ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12/PNG  IHDRc IDATxy\egξ{H ;a BDeQgTpFEgOᒏET*NBBB:{5Uv:]]NRu9|@qDoo#   nuVwb$ Zqȡf[Lhk?hx ??wmFSHtDJ=4pLYrs Clb9Nsxh` mQN!Fô5b%:aD+@}dX0ls )QW_Celr )/X~,TM56IJd[Sp K$ɬZt^myE4  E3gٖ Z4%sͶ8ȲlfdYF;d3&,ϢXo,ۢ-w?ĨJ,D7?Ǥ0o4eL#-+D;>OK*- G-I bR|;@%,0,p,BX&p<"851NVM~=jB86D P1a? =Jk[ ezS4hmAj2m[yR^w 8ְ!,Ɩ@IXin$عAJS.lG1 AJ*pz&@X0L21-!Z9{3mBѣVopc[Hp6 Kvc{Uhԉ"Am^=<|;X²,SDz Z |o!eT~% GEhI$»ETe_I8 KxkMHK}FAS !e) IXw`ǣ66>-@^N1`p"3Sߏhj,O|ho+'KXD"#6@Vb[ x={rmx4x{{<YfN^eZeeXnYmQO.fIQ Iz6dD^(YAUTz sBdq=OnzlE:5 EK< "!$V$`B@ml#fN:MbYq=JmA TS "!Q\82t(g]Z8Uh| 3e£uG9\G,N{9buySt{[k4/ I2>o|%G1~oܜQ< ղL;vǁGd,kZo('a#O&Y@ЗiDaZ(GVKB{Em۟C%TNHGyn 'g䕄ֈ ų@!(&YHiEsaf?%u#j3#t"]¢kDe۩i"E (BE,@530eB|?anౝ"I25 3^c:%@A4;qT#QyGX uUٕ.|P)c^ K#{seKH5f ~/9%Xr,YB[rlٹak$a(n&79L6^ZMSGU4@MFBL;i`Y0`M(ʃfŴ(FTW>yB$$Fpٍ2z-EڍʰA={uz"6Z1M2{sy?v\ٖ7Ũ?$q&UDzL;$Jc1k3QU<@in[mAn)l8k(cph>חsEo@c|l~Έ0b[ke#ɝ63k#($]Ӱp0B,$pN- Sǣy9mżы+$@I_ @qg,Ĵ z!' &ږnW;CH/ Tu @ꡁMi AA`Y&c[I8Li8NBxC"ا.ՇzT/8>߄#i6JJJwIe3E@Vr3*j&"44(7$Yu{oy#GTR74tM4f}n~%E´ C&7]o}yȲa阦λlSiIr$ YQNWO~^UQ2zXz4w EQ^ 2*!h]bEV#/棾peNrҘFAnEyJxx=~TC4v}4vzyx=20MXXGF7F ɱU1%ǟxT/>o]d~'X~ x201hRF'f@Bu⌒ PgSmq3Br(6b uҘ($/TL^N1A_͏,+Ȓþ!s)Sz(‘fzKh\%S1rd  )"9_Yʋ'8 k c /g;%IF4r%äFڑ8IŠRN3V$ Ջz26Chv?2I81bлiH/p?pʋ}H=N8yZu]UwzY eG믿^,ZH̞=}[r?k׮cDnhzYY_Fl ;y饗`(#[l^ ? >^Ĉfp>>yϭO7;/_Nuuﭿy@g"0LhKkx&ǹv5vlA={ɵv)dMn~.HI$>>7oK.{=χ8@i&@=p^ԸYR MquHN8k=5Bҭ̚5W8 iWs@0-ϼa9b30~2kH(xc AxgM%Kie__v6o;!P9 2 ȑ_%Py/げqx4/ë7a zپ=V72<=iB$޴';c?ƐfL8M1sdE}a<E{seaڬYX.|*t~$u?6 ~qZGkphW6>zX"25NYI+ am;~')u$|݈X (=wX… -+V^)m oƍuYlڴݷk\x,~˗;7-&VErґd9)ha|^5ZCeӲ4? 3 ű;cu98 \+Xv-jjx)U7ӋY3(rK﷿ƍ$IvN[x|qꫨfWzҲ 4 N05t<ëx! {2g6=s|Ns<;w / I^ڥ}xb[9ngw i;nL&TA H1)ɍmT7쵷*Z9Z=>hT!3&69ԮhS&zH wSΰ, ܡF8<[A>?Ӝq=YX,ƁL_>4HqLCG74v{䱄^3O,c-4qe?@7&g!l$IWz8(3$}'G;;F7nB}َ¤yJU'>j" azoZ†}'TH|iנ vY<>OMؾ1ՃW 2M5zN(i? Hh%~!{YOןk sEE?UԎ]%uz@գQ|99(xAXthdCǧ$Wmƣm OQz|a}($~pqX0X` Y~8~;g纷y zĄ\uz(((joIJgܵ-%|U[worC{?x}0$  C2zOyy9-`| _W[5ElY~>zwݕ}DX~=wk+M;%mSe6!ڤBlGj~hȲ¾La1 BWP?__6}.˲'߹~=Ԇ Xz5W_}5\s5B!xL>c_txƏ/d1[ȧ>^]wUWsN7m\}TU|]By}vb)2&R@Ȋ,˨&˔'OYxFWqn`ҸYX@X=}f*x ȡ=)MRr i2+nN-/ ʕˬ]?Oi{q+uMϿB౾qR ?VYFe = BDaG # >ʓĤ1)2u)&Ƶ<{ω&T;߻֮P>!+V#:d5-2O$DSS`COGŞht)~XƸA|9C>?7WȊe}h>;41t}P{TL3 HD"B,a֤3hl:[6$H_{1sʙ;'~WwhzE!7,KK0khƎ-$ipOK %+zl,,ʊpw1eӑS" S%.Qdk{#ۀOSj ٤7n@ a$"PeiXa(pgrK[=u43ye|,&o$In&g2~:WSQ21Ӝ^DSK--hlpaC୷ߞzjxʜݻws]wu9>M 0M6^Sk΄x%=u͇cC^Ա1Eʋ'=KZ6.•W^կ~ŋ2}t>rm6njkm3I$F{ }e M0Ϛt$3bmfR#mIUGMDrpIZ|o:Z͛7wm~uqQ%۰+K ,bv!5t_(Ȓ«e, O=_jQ\0Veɒ޴e)B෽)wiΌ_3fuVI.EV]l-aQrUk:ʯLKh49S w`toN?䂔X4Eʀ'xϊI7u‡3:n.#K}9 X2~}|WmH@@ O 3:nF0m[_@!K 7"zj)(*9ge/W?e_0*µ I; `9m4֭[Od~'|W_}+"EC84Ńۅ710,H##-4cbdYMCb uC]AbThB\@1oY{S?رc3kz `f,+v^TOy.Zy,Ȗ%) SwK:pIDAT&kN;`ׁڠܫ JR ,傲1T-~@vPOǦMߺ'{ҍ8ߩnI[¥BvVj| ͏zyg__>$E7tzi^Iscl~wYybь3S{ɔvuԝx=nJ^OO]Ihם,L@<;N<{NL ͔Ng\,‘.{jEV.HũFlu@"J-RN Mp=TJOΡ_@psTyWZp+AGd!Gz((Gy믿ףvq''SV1De}l(8ʳd,$G$}23%5"OBmO[)Zk9RìIgj>~1e/z9^N` *nAnwg/}g:k;!JBJTE= g--ޛϱO$iRfM:!A.{,´qK24t,a",g%'o>c!7֭PL׭0H.yoysarJhٓW 6m- Jvx:=OC  1Ml$aժUl[ 6(Gӡ4QFg+y QaJ-`B``W(NDz[x1Mn@!p}zx(ؼy3ӟ\XiCl6ǧgq*z0ڟaaqAؽK^( 2ܭ6bw3E~|+_jw`3JTTl#Ҳ9PwHWT啣t=z!9SQ4 ^|{ۏ%JN79br>NPC%x4ZaLQrY%3Y`lNg^-{ A=*+'h' )2 Puorv)vI4_?v"54u,͹h줓yS$mAe a,BU5\ed*'ģ塧MɣOxc3_4|dǙN!4`Cn8>IP? ]4|DC8s0 3I+A{DRizxz`[$A(*|qCwF0ǩm<0<7 MwƙGGٴ TE#%ad+Ns ~oX<{N2LQm6iJTR8;8R{T-D$99k+$xD^N!X;G$A=ElOIgUN[H򳒼YVQemOAHq$?tlBXvPؚl@:>VO\6X[Z`WPY:EQ' Lh; y$fz(|+2@e_Ta^߆~oiRw<[US|)ۨJ'D6pZ0PU$a4͙c? aţ0,}&#]}IErN&<{oOwl  %{5mɥ<],{o9"7XD~UQY:B7+"sr4HA2%z d6z4@7\>%yxcZ[Al0 %$slYQ >ONQ,[Z Ji 7eGTl@q7>ΪAw0RidYOKlWJNn8jΏ4W͇WlJ['8nfzt(ʯ$o~.$լ.zv "6cN$jTmѡwPdeX^zc1j{{084wqF]q'dm|h!Đw3&.cfCVN  F;ogtLZ,q"Zs7p8t --1,\¥LIq珛sH1}AmBd{{B/;fwZ%Iաf7ub Ieb\zZIq'yl \yNs 9N4x~[֕sEaqEPͭ DYBS}KhYRt^t;l9&DN0H{;(TX$U@@s=۠4D=L`0ıcAm{ׁ7eTU1oYVR^< Y^y&^y1' ,m0.o\eD-4,$螈%"RZ4G$ɯw9I vx)cx 7x_tija&΄do&;Dsj{s8}޺ږoBU8!V4F iI1r.g<S_AzEP9aY44a+1x~o^OudT9W}0i<}WW],r?kU%ʹwBkƎ,)UK;zBF$LIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0A UUUUUUUUUUUUUUU꪿* * W _ eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQ*֢I*Z֢R"UQR? ! EGE֤Qi?Z_TQQQZQD'U$EGE֤UTEGZ֤֪ԟR? ! $$!! !$!! HII BB HBBH*WfW#_'_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???$??`p6@ F~<@?f?f?f??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13>PNG  IHDRc IDATxw\uߧM^%J:P@@bQ^z^K "* RHH%me?Ιlٙ%!3|<-y>cjBX"{hh=KoamM9U2 44 SgQM[ETfs1 PQϼ~FVye3L(G}{m=i|!DQp s+xiC|ɦnѴ6tCEĵq-eزnضMwH;h15?x?ed֒9*br2j״ _q=q5J4ޓ|ĵHF6=bc@" vq $ewyl8ڙ|~βxߌyY  ^S((ؖe[<]7z!M0 W~QEv;ty?myOB=ȒI䫿8]Ƹ7sW|Q5h;i`ebۖk<2#KchzΓ}+pƳz񕈢$JiK[ HlV̻۶πqk<ͿADP2x{S>?i@\#-9ld {σq Ң#RZ^eywcWXw֧ǨO\}4=}}mk0muA *f2@etlƶ-bj۶DQpȎstӑ%mci]sɜEԉkQbjhuM?Fuk>tۨ.mXzjzU17Ieɜ1MЈ{x[GNULJ+)//OEllhb$IpNr\yQ/EH,LvߵNr^7- l²LL@cDcԷx.YIlۦ(۶yŧah6 Sw&/G֤9L(Fa^9x,E(/ a8?2*z"V/h2SrF~ 9' (1 B/2a|mFcaZ5nڲLJ 0gJ^|ڔ34 (ȤaBɴiZ:m3vi5rگq~Yv4'-CТ$*ؖD;ytOʹcȲ„itx)q: r˩,A,) A.Û2~Z(/BQnh:]V4=69ݍsqUe31mՋZ5JW#0xfTe:A˶h8N$E4M4ޝvŋW4+,}6xߴr7H;zѕi_s4ڨZpKZm\6:,Ƕw5@[W=mue|bq#لwex/?7-xעi]P۴w5*kXAn`6MmGG;R>/M̶m,b+awǢ F=\uBڵ_mv؀eY4A=\}tINխ}h;o{>~?iEQd#>ќK>7-#vm8x|+]W+awmsٚ N,bYM%\#ڨt6v[ LB/ŋ H`tt7Ƿq6~:98ckc̪EWr'a@G//k'~/0/\mLYu}۶߾sV|iOWK/~1^ДD6۾uXp=mpmlyi][i)Xd ۶ih= yk}h#si5|4az|ʡYg>rrrظq#R6J{Qh+I:q#:pGfgi`:L93NԈa~k!,D<ɦ>+(/ ᙱS}AufȎ&Q(nq8\]X~=_fa^9Ey{ClRV\#?$Bv)1hzR嬯мiG;ش W,BĶ,W7pX'ex~#!oyS&wòL,l, iQ,}N޲|8|բhulwwfcfr1-cԎ/3b.f˞#1rGcX$(Yta<>>/mv[ECr[v?뀳nLY8DHr 4C6j>wP]6ٓVq_90Ѣ`ۈbvF ۶9u3FqGwn Eͽ7v>9&J`öԧ߀/AmSU:es/IJLJ k w9d0'/aeXUf'>7em(؍ƭtG艴ZOGD pv^Urc< J2W.aDa |w!" pE#|Mz0 ~H=-Z.b5 \QĶ~ L}Alh.xd3{gX_.ڸ:\IT G՞˝?c8}MG:i>#s6Ui&GwySO(XDzLڎ I ,=ǯ=Ujrom#"3&.N[n1md8 4#v'{p]0 o{=cOAbo_d 0m1z! oa*Dm^jpp4RRʸ{رc?O;|?"~OAiX@<(5 "ـm[d}?|vsT= D<F$ۏ3 <r^}Un?Mk)ʯڵ_5DAY&Υ6^ͮC1o |ꟸĽϢinA$ۏ" " `1\m۶0T9õvq[q1:Ŋ,!ᕭ̨-xN@$['=2Xq+ضEldѬsWݙ䰘Im^'o۔M²M[("X"`:ek\qCHgz'pE_ODYVȒf'ɕD[p۶ټ)6%Ua&1nyv(Q-&ԇ]D4qn7] \u|GFGsHE=V*.fm>վ֣:4I6jQ׼ %S9ָcM{8ڰmo9ݨaBN( n /؇Ξ& )ʯ`jթYKKof)_S>jdQm>#z61uZR{W7Vgxc4xmqq7 NWQi8F{w#ݑ66"j͚59r$w4P5/Ha^)&-g{uFQyGĻri[p۴u׳iۑL[laҥ\g߱7E jNU2F\t^#QDp<٫u2Oz'7gͽ{x43UZ7 Sbpټ]G75j ИT9kɕ HlG3$s 7/prx @4֍inJWGjQ4C%ưl3=N9q)[=mͅ,6nVV̿_,Y2൒**8;$<ϫ[30lfM;n4/,$}Ƕp8kiE(++ Bo-1'ش ɂ`CL!Fhhό), ((#I')4M{5^nViY 3%z]44EaִS+G2DGL1qiY.^uӨ7ndÆ(ÉYoXRRY,݇6fx7q5J{g+ Mutuw8^¶,g ;16x_~;7k~w#pMeyOYYs[4w?w]TUۨmHYưP"Eĺ++wy_@$l>fx[q[DLCw$uCe>'s`9>lO?t|k&~_ ͗wWՌ+$fx30?Em +zx+0\s5tMIG^?$G>n`ݺu~\s5pU妈i Ќw1-\2-O(t6!;{/~4.(:|r _nU- ₕ3oW޻t"ỹ顺;v77uIXch dY&3>{gC=7lĉ~r{\r s饐KX?6uљ`B4tSG .#sMmis~o>`z je>vm\˹s_ 2|ߵdbBZu$b6(5y9K\$)ZH+m] t9ָg?>?m%YA;}T]b:k%ٗSANXu!ȶm ۢ(Ey9?>a_rԉƝ|{0AQWy߲kxH_I-b!vScm~W듯2xw r:" #sH_^P0Y9.!G̃x<ɇ(X njj"Y⪫ҁ|OE Hc9gŇ ذa~\ÔM-_9BB$QXwwX8жmsDё'r tC'FO=%_ ??DeYp18{?r?9WtVڻIklL]* /xWpN:XdwjB"q-BO _m>V>~Ou3gℹXi8L'aӎԂ|_R2?Pv`Ĝ9sX]rzzyᅑ=,f&0>v,^n[- Rf*! ?rȲDcx=Δxsr5~/g>è밁ɕyaq'mSj+@:5oBB Ň(ʈHl3kF MW{ \|~_hD'h̝vNמh[SSQq5Bg7/)rH4Cw**mfL:Va;dC!a8?m/|d2pk[ Zf ַX'S×~ m//^z%Rs #(9㌩9i[nAV<>׋,˄^>_m#DLZ c }&{]F¼dZH8%gOZF^GdUe1LOE+ hX䮪JJ`vVmwߗn{e(Jq~%9졑3k,Ux#)7LaejIDATe%y0%?Ki3 qX&~aXHx|9;L"LτDb]y(HWQ<˶8p,sžw K2,S(HȒYRe3VH~>̦M#FT/ :?dӘP:j+7?&̚E ϔ| ~b1jc1ZQb]]|˲v@©<,bj/'i@Ԋƺi8P@![:CG8I?2:2ek>YKU8޸4S*܆Ee "e6mD]]R"Պ ַxϿvB3YKɧ3ٳ(>,#JEtӤ%!uhiKw]@5N` vbvע=DA(ʫdƁ^{)+Qo>HC6 ?g~Yٷo=Mj>6(Sļ髆K*(Au+؄eVUzqb>==;:ؓt,*MgGvPV84-ԔF$fO^4VOQװ^JMp05z"x=K/9QMٶ-8½n- -r(^/8*4 b==t6e rJ4F S[ߛwsE98xkgmJퟻJƺy( iGw#@>^ig?Ξ&ًe[(PSOg۾LuRQL]u MCFѢQHHGQy dQ;F莴c?ghDI W I =K(ڶ:β_OpvڏPrQW- 0vv蠻Fjjf:h;~ϡڷ鉴aYFa8l-񏄥s/D C4 T-:fU}n0- pw| KXeD:;niq &a .9/jݑVboGuYo*e9z *Q8v 2x秋CۑD?7.mHBpX:IedR~LTU3oܒdAljvvƞ9jhp se &r39SOgkO ߯hͬδISQzx@C_YVraXy0o`Aχ/Dz Sy 7d# ~p+m]ƵkJW⭯ Ա,3YP/F\UO]jSײt{+Lڷi#Dw0 4c9eж(xx<("IL"ϾiGգE5\E m"33$엏1gNskDIB$Wmӭt*]JP:y2=S͕ A P7Ξf8pڻRjy,7<;䱝=Myhz 0 3)+Fo7"CrF@Gw#^2Eaض7}3@qu5k4 ؖa5a*ba:ݽ{TKrcaj<>>q"jƣBԔ7$Ft6- sX1t 5&UCUT-Jnug}G_{~?ktz?G6c:=Nr sٟūjn+gR$QO4Q#'laYX誊 H㼳, M#o;S?7M('@yd޷<7ԕX}/,"'g>ݿxN(P@WMףxՍY'FHF$p6V/$ģPd^Y C%MmnY̪Wx~-8.'h: >eXXOv aZͩԔƴ }4;&- 릴Is)ί-p$A۝sT9/ȝ(8US>O7C1Ύ dKЗKN)#ֿd֭[׾/g$L^:%DTp~8?)2 Ň %,"ǟOЗn-$EAN_H>{)|V&`%tEZDΞVCx=Fm8~'E0uC?GXI\ ,ۢ|msԭ}>rbd^? -hzHMP[FPM,040TA3겙P2 r(/獝w`E *G4ٓSRPtضe \ͻL2\|BnW;ڦjdxkw*w85نn`C}`Qn$qdFBGw#ݍΨVĺ(ί0Ҟn4-%*K#\gNZʲ*OR<YR$ITDA]@nu\v\|Ane3*qKm狂\#LYԚ̘:,}M.mC]U6I8DB6,Y–ny?wO⽓K 5tlvwNMzUO~^Ifݕ8H]rԝ:Kn"N"z#DbDb]In8AwH]['U4Pl ^/60M1M\b}UFQ(|7t۸aM{{ m3g$$9 -ؼ u7Ֆ4m^_8{eE]c ,ҠՍe/8pnbVLןӋ[y?P \ bFrh Cp6|3Vv3| e1L~mۼ|/}&Ov8qla ߳bE㉌# :&;W2f16_AbI"FՉSNcR)T9%'ǿ.̜j>7YQa`;z9w<OQQ2YRE,{8R#\fD74dIq3C'vԒ*!/XDП]OU.Y7%n>Uu֡^IK\i_cd;w{nnnfϞ=̜9x<Α! 6cb E#'PS9.(]ʴw58#Ojl%}ޠ){D'fL\ԪTB7T~$Gt /Nl|]iJ㭊q6)"{xfkMϛC@zd\4IR%Ppwt R&L#s~)6ɭh&kdʴicZu,зTx]I#A$)H@U"a ^O\1G}nf鞆z??TJqA%(uoz! g]%Q0U7`'Q)>+#O_8]K+t2!9+1q1$sßf7FYQ $Gjx1H$)@$ūnJ{Ϟ];=8X&F?$=;%Y` &$YXX(3rS{P»gđ! ż x,I|wcW݈G1cR̞ïH^T#ڡBkg*#ys3cawM?15̱cҢj$Iq 'p ArF|pEJ T9g^{T9}:޷}HȺV: 'K3۶g_ab)Xnjo7F6JSvx&TDQzO.^"+(ɠ aGEס:V m{@UtC4ulۍeNaxG}R[ݑvZ:jyq3js()BTͩxAH/A<Ȳ'64-3r]_$1O\};F ӌ;AHEzx=| (W#)+a]u޿SWĘ,UYOC롬ȱűi AmAS2.#eQPd'$)I `^|3ur[m`J LC~N $#\zwĺ (PP@cD\ /ę俑x7=-t[ؼaod xC*dA`> iC5I$D1%,;ӛa: M&}&SEyGK?C8^te:Ue3 (ԷS"K DПO? ];Yvy`HS[N~n٨]'8 EQm MWG''P0XEK nhtt7" CCOW|Iwи*=vN)@EvD:5=Nz(;JtF̩mP'K04Lˠ=uCձL=~%9=ʒe9״m|t:  %ᡃNfl~͇PͿ4LPZXCbhl;BetJ )ʫr*)5.Ctg;r:q-JKG-6Z^IA$!`.JIB 62_i\|,::u}F^ahU`?KWߌ"x?eIv#tV} )-I=fNA@J]~UQO_} %Iez˶X,s@ARe+bt Gz_-gZsk۶/u Aw9Frz7-30\ah.{yizPXo IYgI ! 5[;X$#gߚ gN64̇#Oƶ-L¶LLr˜@>iZADYenXwKoQ/74x[R|Ϩ u n}%T-J\$FX:B>޸@Ue3(^Z RLP^<'(H*y.Ķd 2tP $<k)BAwC5MKDgw sGHNb&IG<8]V<%UhO2C(,O' rȮ Vuk̉Kэ82.>&QjRJ,fgFsOͻw:ᕶg0ʋ'#6hǶ,dql6rB^veܬ\ ' *'Ė=P{Lf$& BXfĩk>q?ϻ0܀hBDDQǿ9v,սq?t IJeII{䍤`zc 'ok 'Cu۩*Eĺ q-L[g}Rr5yqvImA]exrD̮]klr1w&-C,dGS kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0? UUUUWUUUW _? eeCj*?QQQDU֗TT֤֪ԟ֢FUEGT(TꨴU?֢ZjMjZT#Z ! EGE֤Qi?Z_TQQQZQD'U$EGE֤UTEGZ֤֪ԟR? ! $$!! !$!! HII BB HBBH*WWf#__UUPubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???$??>?D@3;@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14(GPNG  IHDRc IDATxy\U>w%H’@X Ȉ ::#̨EGQeQ6E [J{uz֭޻;03:9ܪg4-I40M4oۖ10A!̘;2cY>?f$1M wʯ*B 4 ~gxu IJ,JFp 'jf#^%IQ$YV1MvmHpxBnh-u4Ru?;o XB(XDe![Q65,,,ˢbٟEE $ըII+H?Y]lYTh$GFLĂ.BHHBBddŃ"xQeeܟ3/DQ)ڣʹE9t0_;53rG>W?ȲȒ6anlA[GJ(PacMI+BBW}<{\qx}sCIXX89A!=><CQ̚YRƝ/yySW:Hjqt=EGh͇u?{6;KW'@6ewN X-\=zғƢYIbZx/ՠTϠl,%5DFVL tSC74t=r=o|J0f.}eǣz%YVܧ4neb&iIRZ-4ݱtzƏ⾇o˫?@dC("MWxҘ:n!hj"Mo0 9|X+wOEcaJY8|Nu#xD(PD"ͺmvu'*4ԓ\9 AU,RZ涣ǚlGw촫z=#40-ih9╍d^wٙNciTq[̙t+^۟ǣ]i膎;B( Waw1jD*JJK(jh9zrmwi覎i٦{K!g|lLe/ ^ghko{ Zy{)k:~a|LMOvc0z&'ͶIt#abAQkGj5r&1R|Ǟ'/2Me96'5*N7>3d}wFz68}Β8[Ijm̴q,K_Q}$dYF %G{Yizԑ?]]ExN&ŋ,6d}D!K]TP΂Ɩ? Yw\=́(gι1'xSyJK!LYR½tSg<)ѷrh|r1MK^}xU!gx G\pabѬl!N(Wb9GpƎň9I!XuMFNtʔ@UX,>SȞr?9i?^n>HKEEA2ϫ}hh#h9rX+>_I urxL#',}n3>OPGɍ4T)[HBBaܼn`ev຋`|\٠xqZׇ E0^7>Ɲ/`:zI"Q{@8dR9eKNД) $If?K, IVu}8L5¡,)sHc5bom{8r| #,t !$g{G#IeRfD2F2%ғovX4xl t=Ÿ9C I&ݎnUd- {saZ5Cѧ`EOw]u+$=5Z:ih>cuEJsjwhE%<_Wc `@B! 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Z;.!Ы/WJ!f& n?:f3222~D\fڶ#s *kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE 0 0G UUU_UUUUUU_UUUUUIUUUTUUUUTUUUIUUUU _O"CCCeeCj*?QQQDU֗TT֤֪ԟ֢FUEGE#RT֪?QQԚU?*֤jU_T֢ZR?ꨴ/j*?ZI֨?ZoTփ[ZBAT֢ZR?Qi?֢GEGRkUTjOZk֩@ HBBH@BBB$$C*W WWf#_*ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???nn$??`4@`P@?,?,?,??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15)PNG  IHDRc IDATxwt[ם?VU[U,ٲرl)K\I6II29;3gN)3&dlc;v*˲U,K );w?^( J:/~_UIeDXB°o0׃?+- j*ťߋpc! 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""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0; ꪪUUUAUUUPUUUUUAUUUPUUUU _UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTeeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! 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""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE 0 0H UUUUWUUJJU _?_UUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTCCCeeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! **?QDH*Rj֢'ZR/RRU_ ! j*?QQQDꨴU?QQj֢5'EGh5TBAH @$!!$ @$!! ! !B$$C*WWf#_??UUPubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???}$}$??५3 @@eH@?Ҍ?Ҍ?Ҍ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 187PNG  IHDRc IDATxw|Uܙ!!V[kjZGݵ_]`{=>{,%Ͻ|{$@Gr|:VsyE{i ]0I)?±qk+Y|LT"1݈ǰz禎Y ]Wu !,0j ^[tg4MfԵ  "x.#el@v|"95]E:!?1"0,0Xv"c*.燎z#zȍ/rKG QP,ɍ^}0n4]k? ;'dɌS.t24޺3}|@B|88\T7>Y1"H 2,kf͢%϶g+L#7v[fWE GAlt5%|$ƥb8^zQIh)6=%z}.0J+UC5"bFiU-zТxRЄ׮CjeԸ8ʚb*(*(UDTTNbǁ-يFa ! : nF[]fX)lٻn<>'B!MW1.FqQI(!3--zXMWQU!c5۩v?wSm9.һڢ{0+д$ lhv_CkcՎ22R#0YJ*WHA l]E5%hj*J@ybo8o w5Zu )\ 2ƠJQj&%8ܕ8ո<5!BIq%df#K&plpf+dưUBs:ش=⃔3w}ml@p GG".ko .|'>ō$$IHHȲ-. 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""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0B UUUWꪯUUUUUUUUW _ eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! EGE֤Qi?Z_TQQQZQD'U$EGE֤UTR*EGTTT"US?j*?A*U"*UU*SBAHHBBB HBB @$!!$ @$!! !*WfW#_IUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???Á$??@@@O@? ̊? ̊? ̊??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 19lkʉy3N&j*u-xLeg4,I$=dߕ7$wM_h(,+$sk׸3D;X":ڈ"lۻiRPK T*~O^-k]}8йEш%e?ª.-p{7vT7I|eg~6yHde$ gzW2e{m)TE MslV/v #@FQT|~xk+ۏd ֍ex4+m๭ps'Mu$!l9 {egs[@:^hY?|ŷyki=AZO(jY+}/w{w_Irn@-la?.]la(N]O;BHq.& A|HcV!۶YȠi?/Roڿ\Njrmc|OF&C];u4_Z?ܟ.N*_([e[\wW}pk#`Vw5ZПfWUn:G=ȋ?vi'k囦N,كad8u٥e)32,c6/m Gz9ܵx7W_VlsI**Iټx߸xicID*5EFOr,C]%z14~o - YV`'9NGnzs?Wr'}&NGEȰpyW]wRi"TMe%cz\^^މDwCt Β p"i=Qt_MQ9J @eM`}Nm UVYX1l|O|oILt:$;˄P.b^Y+ٲXX'HtsIaKott@vzR^U,+yϡ,D7DOiuz $iț$Xۊh;K`:L[؜lC,1289OBד$RS}$dn܃P 2FxC[uL7(pıWqYTVLA8H 3CZOp֪kG6LQdU(k("Iglo#=E2=.j;$$@7RmٳΞvź0-sW_Wru#Ht'cDB"Ν$mrsKnGB06!'G 0-EQ$kGU4~^t 'IlK۟p:IKy+%"8عʍz%{EΞC؎nQT%76[DHdX:z% @ewet6e_m[2 l\{!@^L8Cm|YC>۱wξï䃗|5K.F7f;F,@6wYlPi*K[{ci$ #  ՌZiX,+ei[n#Qϳm ҋGlށ\xڍȲJ"#;ٲɢ -LHaJ4zXy /xD/~Sr[-D`<ᅞ*j&ڞΐæ[ZгrlLXz43h\*{Hqv8v"+ ~^}T6Qm&庋W `X~5Q4V%2IcQ$Wܡmm:GB1c GY~Zcw PU/0w?îW S'@73i*  H ZOZx. 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LfמH{̈eP⋼u~zҒ6?7q]TML٨lv@yj\#M4\7j?c5GE*wćc'ଳ\pl YRm;l,MD^>[rR)E2Pi&ͪEz* &&B6 IIjlsHҸ,P3iA_[2 W?5*H«WGKr Q<˼֕N)YS7|o+ym,T=*l?މIClc ^.ezCC&Kض#ŋSK2]O3$$,c&x@4\C}?TpLJdhq,s܈mO7 'K[oغi9C~mK8DBJ]eL(*5Ȳh ƽc/;w xØR ƍYf gr};N΅i~d8뚙SvɰmgJa@%#(OplOe"t fŵ{{ꫯfҥ| @hv\Oo\H"7y9v䁬jc5]ɝ9ebNttt@$n$DlWJOF=ozB$IrRa܊{ǞQXˋ#;lMI0x:.;x=b.V?{R+Wv 3.hZ$IS]-dyxCVr3K4f R!L&y6pKvcߋhdoqV9Ԡ?>(wwGsln|eY $ y$*v YME3"I`-;'G]k"^ŔFoc҈U KrnIg{8S# ;8) ZrBd~.xp&q_Xw~P㤃>t԰5oȹm fy4y oDpڊw1ai=kc_0x=,Βy=Ns{#P\7h#j |e`YIr%>s(\!!I' '}O3s2!g= S0\7YV@[la-,@b[ssgwf4.5Dꫯ200)SO=UZaB ܶl"nB #sZ*4>saߝ^JYSS¶m.a>7.6.;;1z=ǽO3|d9 _`(~@.:!ٜZC{7K8*6 Ύ ?jqbe'g0ݶ-"j@ʎßwƲ-laS_=}.{ƨo<:Y#죻0E3/Qnȳf%ȒnjgR]ܼ/㺮o?¶'80k9O7@Mupbb=qKS_k9|aH3A̺d7? =X2tTE#sh[R(@HhUPHsM]pڍQ<%i= $%zHf6߱Hhx4/^OfrҊU/>f[r#]f' :Ґr#[X9F<9v>z#=eE*3[{BQB("KJnja ԉ%z%{HLs%5, QgyS!Kb$:ns³`ӫν$$`s ! 8M`:Eet~#0gh |(8;⺙"ILH!:ASL(aP jd~w ܒgɜ l^HY]жM`Z&T/'p,ּrd6{6 mnWI$TC8X"𷇜wܒ,l.浮DSXI:PvDsl@*#~࠴qMm{XYt,vsGa&L]'θ1i1**6z93oJ0m^-NxAjdIteDձy;njj̟ Ӱo/MMĒ,a 3M*Iju:ڼ!+_gk淞hX'Icǝ͊YS1e<3\)ssN}r!i=IZOQT1fO[ O-s͌EGˍuG5M)ҙxAx"@c 9Lw4]}r*0"䭇7yȒ(c -$/K2eBN%xs-rwGk2!9n͛#Q:I$ GLѦ\\6j!{c>yr)ꪦ/+!9qOo0)8Ȓ2$۴x /Ry7rEnt$9!Rּ$W-7[~œݼu]%+WWg *:%?ͣ! %(r{!ؖJ_q ;|{ [ p(<.G%{Y%Njl~rĞg3e`E2ۊ<t$$ &Tz;iRk̡*t=Z6-.LpzHvma f)%\:@oÝQ&P8Y)Lo\PT[Äܰi;XnKCui쩩lv^; IENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE0 0? UꪪUUU _O eeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! EGE֤Qi?Z_TQQQZQD'U$**?QDHUE֪ZUIUS?QQZEOR? ! $$!! !$!! HII BB HBBH*WWf#_gg UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???$??(C?P-O@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 20FPNG  IHDRc IDATxwurz&&777B  =" "EP,.,fW]uEqw-_PBz233g9sK;gf>y['n"9 /YSOal90Ct"z;үuˮdVJ}'B;yƔe|e=E帝^EE"HFǺI%!( NfZ\ ]G7tt]O|-Ξf뾘 I)f/SQRg_!i-9jTDW@_f0t$IZ`4 N .=1~<ꏬ6Ld @$փ,D=c8T0tt=M* u ]OK ;JF[p CX:l"^YE74}±n}'l<#B+3 y%@+1B74tC#K'N(Ii CA},D"E74\N]&Hҏ5$=FA\9{>8 ]O!%H)4=Mg1z#ۑeټ?ydE!Ќ)y@. ;!t4#M G;Yx/rzeeLm; -u^JkIZ MKk8m\Ť)8T'DU]8Nbt?wPQ^NeE_7pkjO =%<u!وĺzA2#6GZ(aY.(i}NqO Yx||NTŅCucSRRBYy)TVV74a P[ס@ [ W^7's{{)/.)">=vRZEqCk9+|[qsEfi6Gt  ~Tm/?)m48wa xKmhDsX gczb좭0i-. <7_5$YF$7=`ɳsYrʼxj|0 tCRcd*B˾L"Idd|FJݤhz6<}j'Ddk% j_A_> p Y +xkHE>C'Y\ϤRisH3 E0Pķnd21M)Dt$ɘxPZTa]S^0'x"`j|4kY #F$@N rz9Oԋ}4=kHc0 E=nHL;ތnH0-I~epO Y,pd:8ܲ3p!t *kgM$l kYKCVo~@ s[g"x]Ɛ0 ϨbɈ9s5W}Ԓ'U!OG8nm♯sΪ,a pgy0NZK݇^gżsPy|&̋g8LCV**9eـmy)&͢~>_N?H:P d2W24C-$fS :vߑm̏1 ݔQ$ojTA"%OD'Mw>X"k8IiqBY`B Ȳ$cC3{J듹 }~IMeÔWODgo3Da֟rx\ΐHkIs^6c}'a{myÜ/~sL˸JTd:g>1]ByI-a:{Z8t|h1aڼ`݊ZdT ˺lZu~(tyJz9"ev.f6,g :wSkBJK~hHElrƮ4~ݲ)+"NunK`;64MYSu! d2ns7 > ,T(Y1աySՕә2y6%*tC% Z|be-fLYR?Yu#Ai-E{QXϥj [{KRf(نwesᶫslŽ_ n9oKgo T;04$Z>Hk)4CC:V ;OSR4!G~3q.}6s$ZlbN]x>v+^OERMͣ((j y[]9iע* :R\7;:a=K0k $I]OLFiosϙv*MQ|ooqr !/ϹC{aX! xwAm& UR$fZ?8p]1EJҩ8=6Q8.$I" esα>q-s)_9_UZhgoZA0l*~o1_'z$V%s\-YӖiGoT7ڱ˙! ~+7|΃ۈ{Ԟ rzZ=}LNpstB 1{)n[mj')A NW̙C0Ka,8Zn!uǡC74ZC/|2;c>84tĆdlo~aiMk+6.턢]]ēaYu㸜?zYhlX>!m| !I膆NN<[yo+:x|OD'F<FU֒Vuml[DӔY|鄵{2afh6:9mґ݇x8.G'#|W)/ӹN0笞cfޖ]mB=0ajO4Ƥʋk1δ̛GC;Ԋ:q:Jwh"4l0wH$ -8ޱP 11iCw !BGQ %BD&~uMqN*@"LEIs}B-Db= .Xwc@vry'h7qOPV\MYQvq+dˤdc;o鄴y2);Y>޾p.ל4'L'h<@kqP3DEQ9wMcT2=Lj[FYQEUHēQ;+cދA%C2rL[̮C% ܱos|"| uS`:`h>̆u#^$]~Yᔃ)BVw,b!0ϝXIPndf?H(+F=`Gb$TԱnٕ^bGZާ_1̒ N.JK!u}Յ]JS-0 ~6c?i3nMKOF4 xf|'61B2Tͥ|* x,BipnӃ'ʏ'NCJjߌCwR]9]卟}iy KK$[}1D$dJP/u]G:ƺEHHx~7\x?!Xh'=Lj%BZ~ξGČj" 3,ER5I3"F:} dI(D4+Ϫxu' Ǻzl>TXfk<7@[aFRƚmۯ+뮻/ɥ]ի)**}{yjd*׭t/۽R%y[7yGn DYq5ٚ̆LOei=~o 4W.YQ4ӜFW_UW]%\2泟,ap7;?[pL37?a5-WȖ4 @BʾBhkhzD2JuE#+FG~sg4Q޶(Fc+ vs߸Ǭzm9ں6PeEVQU'B*KAխOD(+:1'ƺETR@Q$D7 X!xԧ mݖVom-γ^C0Va'(;FɶmF.px@fCN{챜m]vO UԬEn1`U4&MlrQ [fIr4D! 2. 7x#?xƛ&M7… |# L,C0g*0pV(1jW/k,s&>Op"*v~uM"}v1j FܧBcNHɜiݱ"o0OD&-&IYFommml$h5<ˈGhs=xPI  ]GOk5kpsUW #OuUs QF1 X#{?cߴڅ8n ^;%IM8uì$sM?T6 ϖ%enZ 0=Éذb1.׋t A"4%li7os۷/e^},8/`F%E~TrQP4zi"F: Λ#K.k/g{eAR+aGaijBWffLPXE-y3lyd3:{bgTAW!n1fLI6agf̲rB@S8ezt*4n$Y&(iZ'tMug~կhkk㬳zǶw;_ᨙry'VMħ!0v @1o; nO7~ Ic-SkrItZ \s qz<8=NSzyܲ=<{UO91"'`XMKv6?CLnsfT bnxe$`͉Bip2A_)HXW+ VQ,KmyY3#sP6n IDAT-hsʼsY:{ljHŁ:=(+w{kkY2y32KarTZsQZ ?Op8A:h\**ؽg06ZO22ͪ&Ӊr8(RDa0i4yl$ *VϣBو@*So(CyIIf}k6yBְLD+c3o}>({]ՙӉ((j0L}];t MKj!";lf$I2 \!hvq}&$SU]bP.d$g!Hv"Ii|Ns5cY1OLF=y4J/G``;XON[KxA:5dtMCK8YŲ146ﰌi-S06d*Ȓ:|.Rr=MKP7oA7'qRAWK(--% #W2g=^~= >M#z:M2!D[pxkcdi'f:ȽL)ͣL҄ GG8ڶ%STB 3) a\pټAN!Dk0n1bzB]]c|Ox;8Ȋ3(ۙvjt]udEA$ MuqJ7)֏%55N.IN̨PGП"dٹTv.8ùcMF=L.k 9mrj)vWs7CB$`Pkz*#8'=PL I2+{B ǺBpuʸ>30P6<wdĞ(Z]لL,@n7yQUsk.{9҉.>xy}F^~۾ ~.,no'" ACh#fk>΂TEQ1 `:Z*º4Dt*EIU-\Ȓ?7>y&|c TQQ1wEOOIsO~#ErW9x].Z !7 ۲#ɤ)4-IH[thKgȬ$,+{Mt0q5 Hk)bȘ'CH'r,^yZ"I};tMXߚB L^bɒ%?ظq#0S)͙^8rꂋ!ij>q)-@:i3Ӥ$SQ,U *;%#9!9+//H?u^6l]S5Xϸ(JkjN[~BVdU5-Vʸ3ۮ)Ak'? /ӟms=ioƍ\n۷3o<>l>Or饣IZQRYSWbݲބ0(/pLHnƜއU3\xa/CfjMOF^^6jOrTV[˼F;' Y]IZ8@uE#_һ9-;yuL[Un3c1 L6o*v.OtRZ>ϰuVyn喜{cƢj`V)vt0 VݎD2J43&&lLKƪUpO~Nx2J*G5 C!" 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Z;K$Iē̛XܖFґeInb0sO6ZQYfƢRʋjTQ_hP  xKH(ʊeOkI$Y|bH@]4w)I)f^A5 Z: ItF,)fHaٗ/Tʼn$Ė?-"kCojm8Zwsk#x_("}{ tZH&s 10eeR~T$8! ^>NJK:yQxM׸quioD9޾\s#fBn+BZKԏ}\Af ;nY2 ē4==bltZ@ef5(%Wp͹cӺ&u꠼lҰM[lrXb Pv+Xh:¦3H<_0 MK}GB /K2Tia% $dcsu'Sk`h'N`f6Ӵu# +:څ4/A`VɮD7} er)SʈausUIq/ƂX7j{ ;9ڶ{\*o|d"xW攺Rb޹F:H)zCWwVduTfƆ w8h>\Vx]z֧Db=h_wLlI"yeX"$Sؔ|Gv 5OmѸv儢\d,Qhn]>p.$Y(`g3"m.mH;$˼ؼ,tL/"~X.=N @3'!&"1"Sbׇ-,\UHnBxO_k- f{Kf'l菹V!IʸLTp ]h4.OG\͔Sp5Z:`X"SpsəwfmP2B4"P*\(j*i!BaYFlknh̛{ ʊWHSUHAmb^pddB 2 5|̰m054dnz@B.d/dI*TqЙ^7RՕ1aEU H0v~3gOd,0{dぺɳ JM TU &T`LEc=t/f6-Ңɨ:>3gک=Ŧ$7Ʊ!ja%+)+?|e&DTt\kG%+)+;( -#r0 ICAU hDVi*(jBZ$fLg^7i~s^'VXI#V&99\va&3Owabͨkjy{|Qz.]#W-OO$t:UROe097܎Qqr Ǎ^-K0\`1AU6VGQʁIήB.nNU0JQ󟦢HHg:?"AKUdymyPmoYЩk}87$tj ;,@S3Z W )UG%>+jMAb^g}~/(J +@]1w"`xAIENDB`move=1000;blend=1000;3JZEB1c0 0 eeCjJ_RRRHLZmi)j֤3US) o2U_D"aԔ֤ZS/4UOԔU/%/LUTjg֤5TʵUL"&%/)֩$_U&i)j֤3֩$_Z[%/U_&֤%/$ZUIRRj֤j֦jJ_C[LL"&ALLDLLLDLDLLL@11111* cUt,B f$DD$DDI$$DDDDJI$I$! ""I$B$$I$DDUUUT!$UPj"$IURI$IUUUHBUUUI$DBI"$I$DBNDDD""IUUURH$IUUUTH I* @DDDI$ $HBUURDDI$!UUUT4DDUUTDDEUUUI!BI%UUUI$DI$I$*H! dH dDI"$$UUUT""I$ I$$jH$I$I*$IB"$ I"""! $*HI%UI$I%UUU!UUUU$D"@I$DDI$"H!'"""I$I$I$$UDDDI$H$(5UU$DI$HBU@ RIIUURIUUU$!I$T UTDDI*I$I*B$""$I$I$ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 1XGE ffb C֥OjT֩I֢?SZ?ցGJmJԩRDR֋Z/jTJ@WZ[*m I!DHB#y fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTD!B"!B"$I$H!I$I$DDDB!I$DB!I$"DDDD@I$I$""DDI$! $I$" I$I$DD!I""""""$I$D$I$DDDB""""!"!1ubinding site for residue zn a 400ac1c1ubinding site for residue zn a 401ac2 1binding site for residue dor a 1410ac5 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 400ac3c1ubinding site for residue zn b 401ac4 1binding site for residue ncd b 2410ac6 cj1lys->kcx lysine nz-carboxylic acid MOD_REScc13JZE 0 0G UUWUUUIUUUTUUUUTUUU@UUUU _?*CCCeeCj*?QQQDU֗TT֤֪ԟ֢FU֨?ԏTZOjQQTT&UOIQQZ o#Z ! EGE֤Qi?Z_TQQQZQD'U$**?(TUUORG**?ZZWjOZk֩@ HBBH@! HBBBBHHBBBB$$C*W WWf#_?ubinding site for residue zn a 401ac1 1ubinding site for residue zn a 402ac2c1vbinding site for residue bme a 415ac41~binding site for residue pge a 420ac5+- 1~binding site for residue acy a 423ac6k 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn b 403ac7 1ubinding site for residue zn b 404ac8b1vbinding site for residue bme b 417bc11~binding site for residue pg4 b 419bc2** 1~binding site for residue acy b 425bc3 1vbinding site for residue acy b 428bc4bd1lys->kcx lysine nz-carboxylic acid MOD_RESbb1ubinding site for residue zn c 405bc5 1ubinding site for residue zn c 406bc6c1ubinding site for residue cl c 409bc71vbinding site for residue bme c 416bc91vbinding site for residue pge c 421cc11~binding site for residue acy c 424cc2 1lys->kcx lysine nz-carboxylic acid MOD_REScc1ubinding site for residue zn d 407cc3 1 ubinding site for residue zn d 408cc4b1 vbinding site for residue bme d 418cc61 ~binding site for residue pg4 d 422cc7), 1 ~binding site for residue acy d 426cc8 1 vbinding site for residue acy d 427cc9(b1 lys->kcx lysine nz-carboxylic acid MOD_RESbb1 ?333333?333333?333333???????@???0K;1F?ffQdihydroorotase; chain: a, b, c, d; synonym: dhoase; ec: 3.5.2.3; engineered: yes3JZE3jze P 1 21 1BI}BC4)???abcdcabd?????? PAHHAHHAHHAHHMMHHHMMHHHMMHHHMMHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWP 0aa ff ,fff ffffff ffffffffffffffff fffffff fffffffffffffffff fffffffffffff ffffBffff fffffffffBffff ffffffffffffffffffffffffff ,fff, ffff fft fffffff ff, ffXkcxkcxaabme`Xbmebeta-mercaptoethanolaabme2`Xbmebeta-mercaptoethanolbb ݦf fff ffffff fffffffffffffftf fffffBff ffffffUffffffffff fffffffffBBffff ffffffff fffffffffffff ffffffffffffffffffffffffUf , ff, ffff fff fffffff ff fXkcxkcxbbbme`s_expr> Xbmebeta-mercaptoethanolbbbme2`lete|appXbmebeta-mercaptoethanolcc {ff fff ffffff ffffffffffffff fffffBff ffffffffffffffffffff fffffffffffff ffffBfff fffffffffffff ffffffffffffffffffffffffff , ,ff ffff ffff fffffff ff, ffXkcxkcxccbme` Xbmebeta-mercaptoethanolccbme2`Xbmebeta-mercaptoethanoldd v