@`3.6-1h/data/swissprot/ 3GOA.pdbdupa 1WDK.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of The Salmonella Typhimurium Fada 3- Ketoacyl-Coa Thiolase[/h3] [p]S.M.Anderson, T.Skarina, O.Onopriyenko, Z.Wawrzak, L.Papazisi, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3GOA" target="blank"]3GOA[/a] [small](deposited on 18-MAR-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1WDK.pdb3GOA a_3GOAB1  1WDK3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???H@$??|? 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^Ezmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn13GOAB1$\+\ Wo_U֪UjWUjU֭֫jUZUVUU֫jUWkUjZW֫_kU֫WZZ_UZ@!ee KZԿGZ/ԿZkRRRkT!j_Zj_//֡Կ֥T5ZRԿKZ/jZԿԿԿԿRE֥Rj_RԿ֥B 8$,B f$DI$ ! IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???$??|? /H@?@4?@4?@4??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residuesGPNG  IHDRc IDATxwTw>+*Ew%5F%K]4jb{Q.N/afv ^;'n7VIh0 !F蠭"6|{gȲ1^'[ ]&@M$xXb˿͹ccw wSʚ#<< MC+W& ~:fذ ﵯ y.贲]V8L&,̥SdI \ %ȧ740`ڴpYv1|QX10}NG~v7~y:QTtX gmrX޾H$I2"I_g aKYb$ ƌ5kH Ye|_׿瑧&YLu>~.MC #rMEU90&]@~~)&s9n?Mk@[KYe{!7Tz.<ɔKM\2$!x|FH:rt=7u2vkPR,99i$nU*СGҲMס1-+hg(J+WÁތZg2ٲ4̨j; ]߈o3@v- >^۟ nɎ]oiORy\Ҵ[2fCiuÇ՚f%ʒ%io,栃h%//!q慌y׀`R[[!N>Fl7I"t=;gZ'd9ORyx#UU0bDKHnhڗlݺpJJ& ::x弮g`Ӧ:QB457&7wˈFW= EףTV_nz;("˿COhrW0ϙs+|Y4N^#B*FωǛ12KO(fD4׶|I!1dȯsǍV]F_R2M4l6m40! 4}]+)9V tNƺAeefNS;)67w(,!Q\|LL4{}?}m>%>gk^ _Fs)uRݧlwuҹMGQBl %֭WѴ-EK1r0n}'<>߰]3zD"9PV<37hV$D\$$y@}}=;PjVg2/$~'џ| @{[i]Ÿq҅n ^ q]6,C?H[ZhV9 A=jkw7qƝG<6|U.΃.alS95ɕTn{~J|>@2; ee7c6Wi/g}'<{ummv?46aժx_s [/vn/aܸWzG;FWw 'XWa6ߏ^nO@) T*)ҿ"ttGw#~Rs֭o2MҴ_5'oy/:7`קH$F8{<5>e 3|lD(MIzh).I2"JrҩM.ޝo& ޣPyƌ9λh̛NSN9"LӪѴ*d9Ey-{ %b46.a ? ߕtnL(~]ꮣǭ7+1iDQl6#'3Bٶ"%<`4Ngo3`H$OZC Jt#JAAE-H(Ddشi>f~QpFF#`2bY'<\9,^|zĀ.!/&i퇡"?HWMkA=lV6dTjq(J;78i,)2 hP(DUUx׋d"?-!D-??nfGə@QxffPt=Dk$; P]]M^^`OSS6l`۶m'4(6.־3`}ޡ}1 3&hԋ<^CÇX,Ϥ`y7'}\ .RlTVH DMk&d߻HHR׉DvIX Su"DHS"ޝ/^̙3F,^dlC"W O#D/8 +s$e!TU 8yy}H ?I~$I(J KS') Ō߃ @#T.Gi𓰪$ZO]]1d oҒy_P$#տd̓O*;z,OB1=s:ɅWz5qx˻UA!UrscdY'x7kr`ri`#D6`!Dx|57g2߄BK אSAEYl W') EY\g/Ge뽯Vǖ-RP\55JSӣС/~/zÑCmO"Q&7b @< w 裿d۶|ӈDF3q)eegg0o8BTvތ4H@ώD^.hFI*˵/n(J ڈb̘x#q:pLfJee/R,--/_}aQu*X'/ZZo5ؘ闗ZZ`gHӏe7Bw1#5! 0`įuMKP__O$RM[L~ȗͧY. dAqTWP(ٞyV6b̲c+599q/%{g!M +,9:j=?$1u|q$1vϑY`6HsBx-Kuu2l.Ç $ #D]]c˭#}`0}o`R|frrFUBUr4m9֖>uR.keeMj](DٳOY*l X֭D/pD((M{ޘL:v;'`l~8|-47O(dqN!&_d@Q $' ַ.:}OkRii6f;Mی IϨQ `6{z"(FC l96<I?k=LnTt#GǸqg| /f֬3x<:sگ!7jq~GR mD}!Yyˑ$#~f'=NyJssq>p(QChiI5-x<m/,U5=7Lv' X'!aG1a:B$;?>D[;^oɹ 05zUUFd4!"HIrTPx=RyL)X flhl|w!I yy(Ζ-}gϷ?in ,Y_VvBkyy3d',| #wI 3д}EY,f;h/;qBˎD@C$IfGpK [ǃoРw0X%ͦeI2pɯҵrBgn7\u?~e^ H  [<]Fn?H_YiL&DwZ箤e-@5vʙlެ1zu|uʲ?v89b!k0,"/4m`U=6G"IcƼ$ _Cw6x\hYf}I$1ݟID"/pw 헧 C~tv+ƍ*}9C*_ Y>G I.$i*׊[9b\Rr22rrOLpHVZwxXlwbĄ 3i>J1F y~/If;XL Y/DQ,f?_w& 2cz0qa*d!=tIZ&ooѿH+MΞmwـك2;/mxfaC) N=?S~ FzA XW8S8V"/ƝV=0xlz#G.fݺ2~gU  9BR6&>`hv4- wV߯"IEt^x4lдVu3o I2d嗡(K:)P))`*N pe=ŖSpjFccUp8`P躍ٲxy_~$詌_.'0^cƌe̪U#ɛ3l-k .<>@੔2q)=^LU]lg DX,iw:xFPz@Bvf_$+J=^y [M"᧪*9\?dX|Grٮ0+8>dbFZ{&@e䗑$#˗СlI 'O*cQb Ztq55gll>I~7&4PQx:B={GC\ECC!D"vl =-qo.GhZ2y v46 =VyPU5C)- 5OֳX0Yn' zv5D">YNFHS&(NI} | UyJJF/oMCCߏqb0$3ɬz#X!I"BGDžx<єU$"Rʣѿ@|5aH G|| Fc1Ѩ Hw; {_m,MX,,B >L2tg(Tb&r !7w,Ϣim-AC '{S΁$o;#HV)_w#x qD#VhmHMeNmAUb1t /~iɨMJ> 1Ns::c:]G8^Ir;V5 I+3QhYv#ۯh,@^ym@2_DCj!IF㴷˰aNOpݰU~E;{~|8HD e2H芀G:j2NX&?tw5mmhiydgYlسWuz!D"V4e*@ȁ|`>Bד'Bc@huAdOKX~//UgĈC]DUw.RKF\T#0NK}EДƭiCby@㻮'T4DTNĖ6Lt=uPVfE$ÇL"Hd e ! ]oF0'c25N<)6nL ">ߓ|I$ƻI$bON~kj,e;by\Yx; VB(LEz{hZ ފ D"w<F837w0O<᳀em#/٭,=UMZU)UM*BDHF `c2%MDBm,!@׫p:4'AU{ KeeX쵬{N#Kfɹ3ɹt2܉OgN03$[0#>DtCU),<M ד7+z2d\H$$C(Jgg,Oj=x ilu 'Ȗ-w >Jr Lt1@ky mm\-j=X3 ,iqpOh֯1`2L4z]lEnS2L{M:W*x<9R\G &Q%E. 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IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???zr$=?ҿP@?8??G?G?G??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superpositionY1PNG  IHDRc IDATxyYXEAQ5jQLL~=ш6*FQp{⮠(  nl> 3sz6fϜLOߺuV{=9zQOT RS)/B-&V3qG:AZ;Œa9նG\ +pa<t?~Y=_]αDsV~~ZUyjFGWMkݺNRS˴X Jʩ{uq0SSl0\? ^%e * ˁi('؅\P"mo8ʍ >IFNJ] 6l@D6n+or|w 7|/ƩY=]Ŷnush/.x}/'YN=W-ͫؕbO@Sas Ok0T y]GCƓ9>fzjr>*?[sa?z3>l>X{1]MY8cJm~~.w܆s/@!`wz]`{q:#u|y9ւqn;׵Y^S1u_ٶk}ƕ#d{y l!muۙhRKlYc X`3]o=d?ض$39woR%J Vx7- ?F[ _6,<#,߄NY.g1iy=h_~C.8^SM2Yt&;q<2Uol^6:`ec0&`{x{0Ϻ1- zLzq=0-{?`|SvmG`jkHeGGbs7tNRz`ϖ-%prE"c "#[60.>]nUy+JܡM Fw 7CRhlzi0&29 C}-ʀQS We~>IDMedRyXA ߁ H)5Ě}N)O>WCpSp1N_/ @SjΟuT#t`A汕Nx y'F0^k6 ]9}a]}L}9b~q#iF7Ȇޝm=iaeoP|ط܀ᶞ^up+D+vvqPߑ8[/~8YxFHt%yhY 6o-8rE;os @ ta*])4} ~S:T 8 V.ޗ{MpHo]ףE|-g6A*=:FuI?\_84h c ?mh-&xŸP㛦u|q3Mˑ1ѵ.ElF* [yǧ^*$&a>#|nvJyX v/hX|,⩲0nPh/!hqӔ@\+dQg\Eha; [efhʀGXFwчm&|3H*] rAWexZ?,ϻf4 gPxMЎ8*{,{ԖAj"`o1H'z}*RrKW@?(VH6M< `-4G[Oy-=nH iuH;c *y_,(@J8Fx@!EboG1Q1 k`L8o\?Ojˀyx}O_,Qb~^~@&`te@i3Mݴ+_h#}+ _AS{/b}poHF WPo_P&d4@8"{{M_,+Mn9ux'zCP{3J Y}>'"G9k%P`v%ɀ xӔMG~&)v9 Lǃg#Y{`/DFa>?O%,#[fl/l\\KVSP#a y7xFqRB^wl8#6Ay*'slؗ}V&[{a8a#OsgY15,8Cp>2%4jdKZ30A NH Fd2}H9[]Vt?$\8IgdQaX|c{2$CZXTӒso֥aKɗ3𹧓rBr4JE8;~1)΃Ƒ%)@I^ILC(EXy;v;Oo"QMƺux#Fy=L\oA_4bt ,Z (>wPO+VX/^kqX-c ܍ U؉MV62&:eW ;.жSG|ϳ鱘VI~#\WwٲX̾{%lRܶf\C0^AK(> 8Be lYW[ܨƒd,XϜR##Pۦ׏Wf9iE?l4b/Ōɩ:&=;6 AP?CSy'v"cK _oxBtYV2R|!](w~_U0s e++!8#j\r/,a?}1zICڛ8colﴓ}VWZ ~9OϋKIF!;N{H_O#O`\& rɱXt2˼5yν}x}gkvݾnC#HO=FVlnY?4]d > y!%yko.df*d"2 z3U7߅FpC~a=;!~ŧpJOME\}e}l]p>9FHER|7JZ郭k>Fu#eQ}5ouGg lpfkuN 30d"Y\#?q *~ r/ùE6mS/8"Yf/ vM4.Y"˳3[u:bD2j?w\/3!3~9fb67?xC{/mõe8! >(?n$3EHپA0@q@֎%lϭr/(Q|^տo4޽-åM`04|sݏotSRپ5@tXq'roIx"0OgEd&5);@`Kv6r}TÐ1,}Fj 7 `=#y<)}a;3wO{Yв;S5О<6jW*_k.4 \{IJd;^/U0U%`=Ͼox q}l)Y;ld&?2},o%6^G@GW6"{'ަM? SN\ҼEC3x%3i; 6,?pFÁv3VG`[MCHQn| g pu;ay~:4롲!Eك`\D28nMD;~RpѥEo/MF6}O<ѳ1OGB\KC @]ӳ;Hwf< |z]>{*`X#RFGGԝMn7#N"h~_s8b%G$Pw(c+'}aXZ{hLNÊop֪_(]YWB9q|^ؼs>LtCO%=|&AEW; ЍVB&Ûhv O3RTI>h߯#VqXϢ5(?DmuO<&q++ݱ#x-Aۊ^Aب.@9 ;C-X 6$Ù' c &YZ?՚y%>~+ R#RnاUS4GNh alJ^}LgAgAZC p/j|+J׿@?F c->laLo#LQv]3N)qnz gORE#j[Qx$ۺʍa8Og?*rng6'gSi ﴟ (?}r9Y/lk,ћ(^S I"ïE?ػ$S.r&G#1&Ms)},U[NWT#R8<~9 p E͚%$q-r[qP2BUWg!7htW.V80yw"C\EQQuxlqdu\'{ڶFRP0s E/ m>G ;;J#)!CyQb|lόLu.i{ಕy.y,l¥wIy 2H: iN%^ }M{;ڻ&A}Kp`$Wx;<ݥ|Z v3)PԧD'@*1wP6 ~cWϝܻ,bb^݀KݧI /{WGBlQRͯp^$U?t'Pw:\qt`l祍(_6)ˈ4)t"p ҺM`jv?kd(p`[>)vnhC_@/IGRKaЌU6{Cʏ 4P.JK)g^l:ZE-㯢\ gY.Z3/%-_e_qyy6d0| wOឧ<>>#`#ou/{P"@&2:rm0W Ȯ\Pр7 ϗԆaAaw]Oy6бu#d|%Jp F鏟X5E$mP6XKM{AAĦL`ao1tG(γhJ `84tB+hYVq+,ZmFPCҷ)Z=F=\\JS%|~I*Rn'"};Cz[]5KTjLԅ^\Jh} J|?5^68-עJ, 7H!,¾>&:树n}}XFi86nCXiл5MϽjMtϽk7ED` J8҃NF#YTBϯ5E5&k 2of[ÑdxA8ϐMǏ0~imFm5CXz*'ݵgy$ܫ6FGlPYUQ+).:'nF#c?:1C*M2h=H=+@oଈcO!gq^{g;pBWvpS-FQ%3ej2@5Xx R{"E:`,WOPF2V5kfkZhw3UO7=s/ׁ_">+?^Ff[cX,+NdPt٢g+53rNաHwW#\,e&օJJ I1|*/ɡ%~mv-<}8q~I)cU7,"=Bߜ1>՛a[b_۴] ϥ=Nij&SC/3h Gmw“ 0vJEI@_p~ZUdp+ʹSSVb4(Ly3Q;9ql<ϳeg}vΏ(*r;7IT.PafCg_勤'^2a=#RGZ$*:WI2s@#O- >٨ujYBGh\`zJ dY=.;SKT/[ BSOզiMSOզzᩧj@: IENDB`move=1000;blend=1000;3GOA5\+\!~ <*        eee   p> țe";`+U]nqwq90Nl.WNRr-]-k\ΩjmfJso*#jd20fC:ȶExtftn\Dl˼#<<ǡ܋DY٧\3/*fKw{YysRа1>n hh6eԴvSɨY[UZT@mִ˼ecfK28eìzӣ1sCcn6 bݷwn7URa%<2FyM˭XTbTi0aB!<1%&>X<A(\% !Ph PA '@2!,P|b jMS.!5vVmR)RiLJ*0@i1Ҧy cK yݳ2V^][9SZ(*g66M:&iV=T Co6mSC!yY8!,u(ed^^F^ƤnNMKL05Ve5&RiFZMETZz[tDL\BH&pTѱ A`,ٻ̼Rj黲<)\y% z'Y &=JaXKZ( k]QQ³;(KTڒ]o4eH *q2֭RRj (*ht/ST@-kVO yQխ--tRɞ>ls3j_s6vu )TڦH O4T2$RiK(aBd$E皊Mzy6wg7kw5m0˼ا˕SakRT`VԽU2ydn3Nr&1ޝjVT3Rz+4Q-ZVյ[xJ :y$% 0$*:ieK0 "4t:,Xl `T,6Dȏ;jf2/X,xx-fTFlV]nm5&]22g: &+JIhN!ڪj'HIy{ݚneVUN0?5URd*o& - juKS.&ʥڶuN̬ffm/ok&]޳*jNDuP]MdnN5-Mr楪lJYnK[UR+k[T|DTyj"E(S* CR 4Rx|@)NT -"ܝ\MfUe%;49U :ٗS۪mVL=[|DtڪVlsnY{}Ǹ̽:1W;VwuRteSJ;ڝڪ[yc2":4`|!˼DPPVkk]+YBEf_r2 :"μob2s'^he޼l\DFmjw2/2s)TYQh'Фԕ@@$zuԅMJֵte*vΠjvW-[R֖m@­ji5-S[.kW5S3xͣR̋cld츽i'dYc6d2vvC3˸*(|D\2"."21my cf]0Ǝ q[!pȻ9Ek"2#Nu:))/Mj~[t*Hpd. ÎdCa2K824f#Nclc./6" Ű] CH ^"ofȳF6#r{w-f^^N[ZqcڽhJԊRJ&MfU^KePB{kfcFꖋ-o001d u G Мlselcv.zA7 nLD6uە˻](ROZJayL&H`F0DPtH>QjVP$J ⃂`^Bp\ BP P( 8 0PDPn Z'aG( l(l٧^Q -̻-AYPI"%&E%#(]檚܉nml* Hen]íyhJn#3]눋Ù@RH˶2"{lKeӵۚ{yܹZu$bDOJ&jTU&O&jҕm:V)p@SyɗZ۱ K\]]DEjZ礤'ZYE;]T^Ȅ6`rwVaR$+/rc7n72yTܩZ$A3_7^)vi-4tL&)^keݪR AKRֵ Z)U;$G".1LVwez64A0 5*aױ]l`n;ӠUR$>kj]rjKD=aQIaTYSTZ#BH* eb0V )%I Ijj$T۫ݗ[rbtVeL hZیܪkM>(Vf2#YdFuĔE34]>\ l0` #(B0L2b A#_8   44UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn13GOAB1; \+\!ee KZԿGZ/ԿZkRRRkT!j_Zj_//֡Կ֥T5ZRԿKZ/jZԿԿԿԿRE֥Rj_RԿ֥B 8$,B f$DI$ ! IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn11WDK?%Eo %Eo  C kQUWkTG_j֫ZF__jQZ_ZkEUj!AD?kUTkWB?U#Q֫TGZ?U_֫ZF_D֪W֢kG֢֠VUGZj AZCB?E_hU֠P֪փZP_֡PPWP_ jADB DD"D!$I$"H$"I$$"H$$H!!$!!"DI$HI"I$H$"H$I"H$"H$@ DDI!$I $!!$H$@$$BI 1mp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$D""$"""I$MUUUUH$I$DDI"5UQ"""I!BI&DD! UUUDjj&I""&H5UUUU UUP$!H$UUQ$""I&$DDI$H$UUTH$5UUUUUUTI5UQ$I$I&! $UUUUUQ$UUD!j!BUUDI$""""I$I5UUUQ$! IBI$5UUUD""""$I$!HBUUUUUI$I""$I$TI$I!BHTI$DDDDD!B!B""I!jjUUUUDDDDI""""$I""""$I$UUUUB$! $ICUUUTI"""""I$I!B!jUUUUQ$I$""I$MUDI$!$UDDDDDDHB!!""$&UUUUQ$DDDD""""OM%binding site for residue nad a 1001ac6ADY]1binding site for residue n8e a 1002ac7 1binding site for residue n8e a 1003ac8DGJt*1binding site for residue nad b 2001ac9ADY1binding site for residue n8e b 2002bc1 1binding site for residue n8e b 2003bc2"%PX*1ubinding site for residue hg c 392ac2^1binding site for residue aco c 3001ac4^9Z1sbinding site for residue hg d 1ac1^1binding site for residue aco d 4001ac5^9Z1?333333?333333?333333???????@??+1WDKAfffL?p};+3GOAAfff333?p}7?w$??@!@A.XR@? g? g? g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17PNG  IHDRc IDATxy\U>^ $솰QAFQgDDepdqԗ(|QПl,%!$@,ݝޗ{[^=V><p 0 ȈmP-4'}u.z!ip5^̆C\TbSy~#Ok;!!6 _RJ,0@J lMEUH) G{8`W 3Nj )H4' Ե,{~1RJI5"]$1,krrr}(}jؑ $SqeZB\qGЄm̈́&t4MGttͅ]4X<GQ\ |p$ $R1 3i̩]ʑcMϩi3_IӮFt">e)Au\.n݋ vxϖϣi.4!ЄFgTyFL&IK,>ԔPWgD*N,>@,!!- Pw:u~_' q>޸ %ƴ 3& wwҒGJ , 35~W!@h<̡=HiaZ&RZc?j4Mǭ{z5{ 3E2GNqò ,@١@)#&t[_{%Vy9simyl] xҒ'g\&!'of i&̓z>%ƣ T+.Әp'$0wr4M-3u)jKLL9uB< ;߈YhOXr%sOw'$ D?)U$^OE bY_5BcJ*fK|t{G;7˃#OFI$f)ZsJLi}`n'G\?҈;y&T&/ǭ0xVso94/ YR]Ju駹Ti 0n9ͭs:ɳ킏*ŋՋG LXlRZ9 +Wm7Ji>D{!?_,]H,[wst>o0]$ j 2f G_wڜy-g_y[?;m55xjo#eYoC>s4ՠa4_ei !vR͟pӻ6 !w^]w`Z)L94h`سs>!nxCUsnZW %TOF тG=W@h…+MoN̩Y HvuSy蒽gQ:<ŧݪMGu7++#laL'L e$0 21H4֯4MRF8Z԰x2J ]supԦWl)L<~o!Ȇ_T9b6ڿW/> ېH^ \t'[`͒ kAJɰ ei-8դY Rt#Ou\Fo)%[^q N;";¢CJ8;΂cMt IH 2CW_ Pgށc<½ ]7yrt?)ijȎd$MՎ EL#/ %TaYfNp;}M9L!"iB_3k7٤(GIHWGeM\%%rrzxKxSg8QeTB,KivĎ^LM!4t %NHc"EnlD{WԲkqz+xi?ܥjM%,˴sϞ蚎H#ܚmu&J8ɣay|툿Tuo|cǎsNn馬^,Ws Gڏ?qHYk+Ų+:aɣ.a5)6ر|.aHSy`q\[Ջʪ A@\ n,pn@8 E*E pD;$jy~5jڊFRfyoxK$ Ҕ?NP#sTL!PQ󢎞#CUN$7];%kkdVe#)CEvf\ hNP@ eWҟecFQ%o0L!9f<*Hɳ73 Q*?pT7xr)HCbxpy!fC҉[oUDzQ]6GHNZ| ky$uG_Wg3>oй[Ot@P*Cb,NP1Idq vz)M6'8nwR{,q ί]ɉ]v~ ($HK{BG}tJRrH}vnE'q6չy*KAJǻrRŸ-ϩK7giTt Oh@:"J 5dO~Q7B\\^B_0̄ NN1VcT"KJsv5gH\z* U:'!Xz-v88u+p;!7U27sq r=U/ )h眷"HyHA_IN߭(D3&8\.2*`8w4o,=Ms08öH\囑'钉T'ʙͥiTCt[e M?;MXx1?K&a`;NYH*T"D u3NǐEY{)FZU7$TQY㮮<5nզ BF.:L,QaW]u?y≑󭚛 >~6l>ag?cǎzꩼst?{5.`*#A4āAGԑd$!gu\tM'{ BhBQo&qr 7m۶)__8|0Hzjwu}{'UēQ'ldY㙔Us?wC(.݃`Z֌-&+sCQX\DzH\t.6Ҏ?k-;３e˖#%Oq_cWm$-i؇bI@f8iȩ~rrsL9.o;V̓rV|繅 k#߾FYšaǹttb"^\25586YT@_a555y@ūѣcg\Xx6筻SoPp;s-%uU8xt'*\E֞ILk~S/xC?e_l>:]7G{{4.s{(|>ozR$1$n5fZJIx*JHpQp\q#[>`i&V_Gk*PZTdrNllֶ(PFQH4w7w-U0}6Od質~qV\Zۛgx'ΰESS{.=ܔ]ZT:() }v~}>v!)vgx?]}G) UoCbjѹ b>[St:'xix@[|og3~7#ƫNNiQ ~}|K_E2ɇJ@D2a8ز@šrWrʭ!$W_tɴWTa!qRM7j*RQRGqgv~Λ믿;cU7;{+A8dK7Q]ހkm_q ȦOfO=hZQVVJYi%ŤR)RFT*I8>(ibJ 4{&3IP~oA)W_v7,I QY*X 3HED*F2 99jZ}4qai" a ?2'&}cScջ2qKxL%b0% [kw#n/g熿n$T8(te|"amps?cdԑ]d"lc֚md+-#ˑD(_djq8'S{!"*Kf=7x#ߩPD3G@EieK5' 5svB"#oF*ߔ&Qfs(Ĺ^0.,M%rZd'*=?Uq 98dPQ 7܀oz$$S1vZv|w}T{/ڇWF#;..!s7p__qq{F|c%ZVRD2(lך~ZWP]6/zλxbUs/-F4z>u'@d @)z*v|o>> RJ:,6lLFyS[1o/}|kOrmM=j*RY:j^v˄?{5.G ,'2-&N6r,X4]ڥ|vX, Hüp||;Ƕm?_ /JBU*!OUlJkp<:Fsg-7/[1uU 4G46@Q6gXU6;+ ^bYKBhB'#'vzC ~$ gu$~|# /u z_(ІCP͌'JN7PYZOeY=eԎ?o"{J({ᇹK_yž5o}+_X~\ۼ!$SPBS 8Y\I7tuW2-<:{ cZ(2F LqcOu0nl1͟1wi_= `pׇm""OChjyy>r?Txr54LȱFJOSV*3r>RZ8Dh,L"?I)TL./² (١ᅇ ϷD"u]G??z~õ$"Y{*͂kF=~X ;675s=\5k@P,svզ9$70oBW]Bjyrݲ3@V%*Y(A|Ul믿^sϕٓy yM7I's83>^z=_z~udy,YV\+KjdIQ, Uʢ` d(P*R9\"#+0(WemK4~{G'7,y|,$>}kttt|'i yoh`X)y~@^^sd2JBU2Y1Cy g˥O X%pVIDATy}ROʠD}Ey}oVמ#9'wyܼyfL=}_{ϖlfg^O@{3eӤQq'%wʍQZޜ #aTp>>ZɞAEMhʹW nglaɱ&ӉZHMyrZvq}/59{4Ͷí?B۫GyE7!eO-i!-G'X3ݸd^;e,( p)7_Wg&7=MPK9֯:?4MGaթѬꅜzb}2RIZ=C8ͶDz ,⡧~45 *[`"pn?-2}}}oLk-M.)FxM] IU O;Zچ8qO7y4֯;cZP(ta籐IEQ;ErB60.ݍ.ݍI|7OCȠ+- a@ 9jXY!SZHibZ#bLJIP%B(l.fqrJwn~W@o³C\ @NnF\Ңj 0D?{ʷT[uӐ`kl #Ruk?u5 W1Tij{~#cOOMhUOB,ˠ`37n]p?#jŵYξ}EH)1$)#$TIQ _JH/*9{B=b=GwԲe+C˲7e}tͅiZ2VPS1ǶW)/n_欔C 5TK04ˈ+?ZGˏƙ:DjI_ؖyzr5j>{n⼮5*6hi 嚚3-aY&sDXW5y=%%tMb#pP=d*^0qywE8u&-XG<x1}+_aҥ\y啣[KE[g]tCK29NsOCJY$1vD A` lwdaZg:pd#jkjRpnϔ䩧=vmv(TۿΓ|[]IK\C*=<92b؉e1VAnV{ys)gol~ؿ aL\ .G"vNفetaPS6SHvo`,獝Yv)Np]wuV||[˟{s-DZg_W`IkV5ErBR;j*d@>›ɦ펄hl  pG^M…p!I9m\՗cZEN /آRY&!RDx\ӓP'5](<zJ29Զ]Nj2Gtʊj(-ƒ&=vF ~x~ (3m|qJා Thn}97UaKB{gSk鈻yuinU{>͒y#U[yz}J(ʶ^G@jqY%MZ;p4TEWQ}vc8TI* =DG_Rn9Cz1ף'y͸t7.E,?Y[{'}Wx[ /T )anjyyu+r@ Mļv%(zD2yg8 U `aq8h\ {9K8+y@Ǒ0<>OOO1*QwlPpn]t&4b|A/o4Ϟ<'3|뤹.#gY㙘CcJ}arfoOgv47xɆsZ>]>bbx8X`"x :ZUS'RMiiqPȡc8HN,E==fzgFWu$G;ұ{=iڟ}ǵxe-gҬ7y.=N7\H;'^h,Lk&=X,4 t-5J$9Fičk/2-~Se82dB!),鉾>G'+/ZrQé};Sc;LaIMY:Hx"aV|LS HY@/V )Є*l:HJu7J%t 8rl*Ypj(v9G<Et{>zLEց`ɼ3*Fiq5^ji2SXf=FO+}NGw!(.Mҹ?g#T!xNu|tfLiVZ/5@JR1fR`!%=,LSeJ@Y>kdk2Lotf ˭_9 B}>'f,RX1>A!wj尥hZyj돱b9yXʒH,t<iy6h.`f?{uuf,26#dž)%x߈!aǺX>#V]/W_K,4]M̜Ʋ& 4ul<}39 )߀ Hm:xHչh$,|&mô >TR|@4]ךH7_Ľ|[gN'a_eWo9˚%oɛ:@"d S{Ct铍UaRDuڻN9b$t|d/^>q~luOPQRgKX9Q,~KKDL2$$T'J2NL4rVWI! N'ӫٱB5 &˥RGKs$ R{HҲtv`B!X8o7m| +qTdxb&A\-mDjZ6:4y!A{ZSauCmf<)U*ic|֚wc4Er#i$ d |/XE<8P pa{opot#,0hCBkn5?k'#=<&y"ޖPNNlOZe}8.>]w-*K(++%-'c5‘.>"c3*i%;f%8dtTQ:O۾1B,1oC`A :N_~ DTM-'`_kI}26.w $dL՛[~7KUYQ rD![MtIENDB`move=1000;blend=1000;3GOAu$\+\e UU_IUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!ee KT* /TQ֥j_ԿRj_֥KKK *B֥ZTQK֥֥/PG/ j_֥Կ/R֥j_KZ////ԿQDԿZԿ/P ?8UWW Wf#UTDUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUJ j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn13GOAB1; \+\!ee KZԿGZ/ԿZkRRRkT!j_Zj_//֡Կ֥T5ZRԿKZ/jZԿԿԿԿRE֥Rj_RԿ֥B 8$,B f$DI$ ! IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn11WDK%Eo %Eo  C kQUWkTG_j֫ZF__jQZ_ZkEUj!AD?kUTkWB?U#Q֫TGZ?U_֫ZF_D֪W֢kG֢֠VUGZj AZCB?E_hU֠P֪փZP_֡PPWP_ jADB DD"D!$I$"H$"I$$"H$$H!!$!!"DI$HI"I$H$"H$I"H$"H$@ DDI!$I $!!$H$@$$BI 1mp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$D""$"""I$MUUUUH$I$DDI"5UQ"""I!BI&DD! UUUDjj&I""&H5UUUU UUP$!H$UUQ$""I&$DDI$H$UUTH$5UUUUUUTI5UQ$I$I&! $UUUUUQ$UUD!j!BUUDI$""""I$I5UUUQ$! IBI$5UUUD""""$I$!HBUUUUUI$I""$I$TI$I!BHTI$DDDDD!B!B""I!jjUUUUDDDDI""""$I""""$I$UUUUB$! $ICUUUTI"""""I$I!B!jUUUUQ$I$""I$MUDI$!$UDDDDDDHB!!""$&UUUUQ$DDDD""""OM%binding site for residue nad a 1001ac6ADY]1binding site for residue n8e a 1002ac7 1binding site for residue n8e a 1003ac8DGJt*1binding site for residue nad b 2001ac9ADY1binding site for residue n8e b 2002bc1 1binding site for residue n8e b 2003bc2"%PX*1ubinding site for residue hg c 392ac2^1binding site for residue aco c 3001ac4^9Z1sbinding site for residue hg d 1ac1^1binding site for residue aco d 4001ac5^9Z1?333333?333333?333333???????@???$??+?&AS@?n?n?n??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2%PNG  IHDRc IDATxy]U? w[s%5$<!@~Tlp-쇢LB+6Vm~Gw"66-mL:4 SJMw:~[U[u+r}oH MJKliq9o=B(XAH7SWHlNꫛ1mg~7%?"!!x~᲋v"i$ ŽPz( R"8F6G ?CU)%RJod[y RJ 3aOtOE%W{J 3 \.zx`X~1 Bp?ESPdFJږ !H B(fյci-%oby$1 #MHp$`lB(&`[&L7B"@9{2[l| W|B,Rm]۶--z:hvYUqp FR:ML cIg  DH59khoYA(~0yU(BA((B oLaZX_G89k;FzwZ1'Aͣ޲)0 zlRt 8ͥlyiȒ 1RBu |HRKGj,1UNlmK\ ].Qlg0y;>џ;ֱoDQ4V*yȘ)T`* Z@`EθHE ;+g0ϜvGt;3lcZI=τcB~\"8S80 V ɳ N"l"E&ֈifz:H^+e !~^+::n_d0$dH(NCWzd"mNe`<.Iń-S2̐LJ3D)xU7,; }iF9fSS̐LJtԖC3 =M`KU\2= y\x:~GGS<:ٶMuU#BO[}ɾ&EY6C8WjAcwBݽǰm%?I\y*9fBP4W!iE |wOP񮃄 WسDUQUUHâd<.EEJV=WhgIʞ׫Z](;)g.r_}u,QD>Y_=f& #e2Ԁ[/-Hh.y'y>C5-*y^8^ፁHVuWrH#VP 5;p:/ y\h0଩jʱdgf$H{mN9%L@gR2r5P90>d@:f,zNygBU4EEJIUn*.G%r)K\$R}s@X]=GhiEQ0Үt&I]u3ݽ y\ 4]Y;*@^%7 A@]0[ڊH>Ҷ ]?RAxs9]eCM+RxPU EQ0M;K`vH7ʁ=.H# D¡IR2%!O(EU5A6@; |uU{ ,X ǖ-`璛L5$Sc(MH{.lTE6>Uؖ@RTD2;U6\V0AQ4, vJg%ԁR0HL"t",'VT:n[.' i#z(tЅE8A9?M/:ɳrfou 3ɂD[9JI7TME%c$y͗*]ӞqMHu-H@ZM Q䩎5r*K$]q53At5o[ALOOǏgҥ,[;vቦ%yz-f>`:֘%Q0J@ kA 3 oT΀4T~yfoΊ+xWħv䩊Ժ3i>ţOc zH0F0E(ƫj=1j\r ~ xR[/ϻhEӓarlݺ^xhu*$A¹k͛G^)ƒuzw`&RFL1F۶?Wđ)NL;x[?fZ.2/ \ц bf@)&=}'nts?tOJZŀeY Y e_snؖ<)LrE<f[3&)Ih2OzÎ{2˾‘ )[V[P t  EidiRTAv[AN3 !#`Ju[Pܷr<Qqo6yqP{u|n&k[jxȎYϝQ1% 8b$F뮻x_Hm۶:?|r(˖-P(=3⢋.[ootY daII!UEIMեe@ ɀ a e0@TQe8G=W￿Hȧ&S&me*)衼+Q~GQϓNO"Њ;K.~;R.HT7x/x_Ae]s5aG$l3iTT3栧gd!g@Aנ}v z[Djs1^-/W\e8`mNb3pw[.^~>pq<C]ǕW^]Fw?|&`~2TCśJ?SUCrݺuιO Ysk.y͛7˭[s\x5ʜ*^in|k$mvdpg$;>;wvw]Îw'{s%Ȼ fɒ%߫~CҸ!ݻ 6xE9gP*k׮W_}uߝ.1n/.]{(g2xfï5bǎG?͙^>:#Hwr* 2|D`Yx[w8x WHs!uE10Cq`ѢE߿e>s477T۷p0} Rx2[04C1vZ-[Vկ+V?ͮI$'pR: V3~~IT `…<ub )W5G y*~.z6m4a<0or7hmcl޼!P~DJ`:'Ab?{G8IY_"kZe*d Wx$:7bY@!ׯtMM_]mu:UUsOpU((jY TQ sU!ĄDbU7(xl$/2{졮nm?DB!I|ύ|o/qMUEQKTverK-rقrMok-ryfh:9y'kP뮓/n$oG~k_;|G>#/0H~keh[S{Z:E˕.+:o?al'̿Xo]wNQTTM/xV?G>2{p ']wݨ֯_/|#ruMrn2m'Ϛ+έ*R[ mU.h]%[UEK!#iE9r͒mrmUƣ*YvmM:?AYB!ɖ5GJ-%bnlXLT6Y3kZPMlL1?25<8Շ=& ˂ûwFQ|Aۿ͞c|MpKށT%=H۬)R L. #"?wngc_\O~8]v܉#$9wy$mUk#C@#I*24.?ɠ,S5߼-lXq-p?8%u~#8'xGBh akqꪫ!s|j^ZZZu]ݨgբěEUUuv/!p oXOɼbZN|ށӾ#Xnd?TPP/%/^s,RS_-$jKmU?LHI43ӊ8NQdV_i"g] ^Nu <]mh2(B P0/Gye tR2u%;Ejh3C[S\Nu6Ѳ 3SP9CQnkբhNK`l|O֦Nx [ڴ5ubK۶8&|&a` KECQcIhd=ݰO<@" uȪLx(ٶ,Mu+7~x\לzgTaN鞷ꩼӢBQ1VCQ[C'^cd$ԍPW6,͍ R"\f2fIDATK"D0Jc6UQ)zpɪwؑlPU@0먊i躆(f4H$$ ,rr_=)񅂢/O4-dά%W7 WOŏ+@sC;=ھ|q ecIX9wؘFG(1FHc&meVQQTE%ɳK($k[sT7xPMI mײ&B0#ͩ03d qqVi,ߤ]_LQiX;UNkB= &{9v@ɞw*$oߛ%oG1/v\Ix5p$=Co_i#ڶlU8sq&N2Ft&AH递*o]ECm+HpP J23ڄʻdgI2ft&AHLHV?_S<"5'z[IH(|k"jc"Z˶Hg˿}2r3,Si#AuŲ_Dc\TED֣Xܾ|.V6/H0N(%ѵ 9S`36E<=AIqndk"Tx.c F t&p&jmZB 㨚dۼA˶\?i #EHbilߕ>=#l4U'm$eφ|NJ"} Pk:n(*@!-kq\ԬrsyWW݌h$R9;1cu2+Jw:@ׂT5iA!ݽ+]aբ;pzUҙ$3 t-0b~2mUQr)m:23P2<뫨f2Q/S $p<+XtCc+`"*Bqje=wĶMEve[F4qGPS[//g0M(4Դ%KV0A5BAgH~jTr:B 7|g^3\۴ TMAӝ!figq2'rtzBۚVnKO7ʄ{H;"DɤW+fvC!L3j(hw_w4ϑ3=R Cմ0xP B"5qgî5Waz=fa&ZlJٍEjt W#`ZBTz"I`&=LKcavL m$PUg!b00CLK(Phn7:W7d"BҸ>H1Rh At-(3ragגo~nz$qHd/}WIENDB`move=1000;blend=1000;3GOAq$\+\d UUUUUUUIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!ee KZԿGZ/ԿZkRRRkT!j_ TQPTQj_//֡Կ֥T*"TQPԿKj_֥KԿZ-j_j_j_j_ZR/j_RZ@8OW Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUTj}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn13GOAB1; \+\!ee KZԿGZ/ԿZkRRRkT!j_Zj_//֡Կ֥T5ZRԿKZ/jZԿԿԿԿRE֥Rj_RԿ֥B 8$,B f$DI$ ! IBUU$$BI""""$I$I$JI""$DDI$IURI$I!BHI$DDDDDI%UUUHBUUUHBT$U*I$$IUUTI!B""$!*I$""UUUTDDDDI$@!JUUUUUI @H$I$UTI$HB"""""*I"""""$I*@UUUHBU$U* """"@j}binding site for residue cl a 388ac3 )_ 1ubinding site for residue cl a 389ac4|1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RESmm1ubinding site for residue na b 390ac5{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_REShh1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESnn11WDK%Eo %Eo  C kQUWkTG_j֫ZF__jQZ_ZkEUj!AD?kUTkWB?U#Q֫TGZ?U_֫ZF_D֪W֢kG֢֠VUGZj AZCB?E_hU֠P֪փZP_֡PPWP_ jADB DD"D!$I$"H$"I$$"H$$H!!$!!"DI$HI"I$H$"H$I"H$"H$@ DDI!$I $!!$H$@$$BI 1mp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$D""$"""I$MUUUUH$I$DDI"5UQ"""I!BI&DD! UUUDjj&I""&H5UUUU UUP$!H$UUQ$""I&$DDI$H$UUTH$5UUUUUUTI5UQ$I$I&! $UUUUUQ$UUD!j!BUUDI$""""I$I5UUUQ$! IBI$5UUUD""""$I$!HBUUUUUI$I""$I$TI$I!BHTI$DDDDD!B!B""I!jjUUUUDDDDI""""$I""""$I$UUUUB$! $ICUUUTI"""""I$I!B!jUUUUQ$I$""I$MUDI$!$UDDDDDDHB!!""$&UUUUQ$DDDD""""OM%binding site for residue nad a 1001ac6ADY]1binding site for residue n8e a 1002ac7 1binding site for residue n8e a 1003ac8DGJt*1binding site for residue nad b 2001ac9ADY1binding site for residue n8e b 2002bc1 1binding site for residue n8e b 2003bc2"%PX*1ubinding site for residue hg c 392ac2^1binding site for residue aco c 3001ac4^9Z1sbinding site for residue hg d 1ac1^1binding site for residue aco d 4001ac5^9Z1?333333?333333?333333???????@???0K;?ٙ3-ketoacyl-coa thiolase; chain: a, b; synonym: fatty acid oxidation complex subunit beta, beta- ketothiolase, acetyl-coa acyltransferase; ec: 2.3.1.16; engineered: yes3GOA3goa P 1 21 1BBB??t?ab??? AAHHMMMWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW\aa *                    fff fff ,fffffffffBBffff ffffffffffff , ffff ffffffffffffffffffffffffffffff fffff ffffffffffffffffffffffffff fffff ffffffffff ffffBBffffffff ff ffbb D                    fff fff ffffffffBBffff fffffffffffff fff fffffffffffffffffffff fffff ffffffffffffffffffffffffff Bffff fffffffff$f fffffffffBff ff ffaacl'ee Xcl chloride ionaacl2'eeXcl chloride ionbbca'0bbca2'@4bbna'?awaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262awa263awa264awa265awa266awa267awa268awa269awa270awa271awa272awa273awa274awa275awa276awa277awa278awa279awa280awa281awa282awa283awa284awa285awa286awa287awa288awa289awa290awa291awa292awa293awa294awa295awa296awa297awa298awa299awa300awa301awa302awa303awa304awa305awa306awa307awa308awa309awa310awa311awa312awa313awa314awa315awa316awa317awa318awa319awa320awa321awa322awa323awa324awa325awa326awa327awa328awa329awa330awa331awa332awa333awa334awa335awa336awa337awa338awa339awa340awa341awa342awa343awa344awa345awa346awa347awa348awa349awa350awa351awa352awa353awa354awa355awa356awa357awa358awa359awa360awa361awa362awa363awa364awa365awa366awa367awa368awa369awa370awa371awa372awa373awa374awa375awa376awa377awa378awa379awa380awa381awa382awa383awa384awa385awa386awa387awa388awa389awa390awa391awa392awa393awa394awa395awa396awa397awa398awa399awa400awa401awa402awa403awa404awa405awa406awa407awa408awa409awa410awa411awa412awa413awa414awa415awa416awa417awa418awa419awa420awa421awa422awa423awa424awa425awa426awa427awa428awa429awa430awa431awa432awa433awa434awa435awa436awa437awa438awa439awa440awa441awa442awa443awa444awa445awa446awa447awa448awa449awa450awa451awa452awa453awa454awa455awa456awa457awa458awa459awa460awa461awa462awa463awa464awa465awa466awa467awa468awa469awa470awa471awa472awa473awa474awa475awa476awa477awa478awa479awa480awa481awa482awa483awa484awa485awa486awa487awa488awa489awa490bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193bwb194bwb195bwb196bwb197bwb198bwb199bwb200bwb201bwb202bwb203bwb204bwb205bwb206bwb207bwb208bwb209bwb210bwb211bwb212bwb213bwb214bwb215bwb216bwb217bwb218bwb219bwb220bwb221bwb222bwb223bwb224bwb225bwb226bwb227bwb228bwb229bwb230bwb231bwb232bwb233bwb234bwb235bwb236bwb237bwb238bwb239bwb240bwb241bwb242bwb243bwb244bwb245bwb246bwb247bwb248bwb249bwb250bwb251bwb252bwb253bwb254bwb255bwb256bwb257bwb258bwb259bwb260bwb261bwb262bwb263bwb264bwb265bwb266bwb267bwb268bwb269bwb270bwb271bwb272bwb273bwb274bwb275bwb276bwb277bwb278bwb279bwb280bwb281bwb282bwb283bwb284bwb285bwb286bwb287bwb288bwb289bwb290bwb291bwb292bwb293bwb294bwb295bwb296bwb297bwb298bwb299bwb300bwb301bwb302bwb303bwb304bwb305bwb306bwb307bwb308bwb309bwb310bwb311bwb312bwb313bwb314bwb315bwb316bwb317bwb318bwb319bwb320bwb321bwb322bwb323bwb324bwb325bwb326bwb327bwb328bwb329bwb330bwb331bwb332bwb333bwb334bwb335bwb336bwb337bwb338bwb339bwb340bwb341bwb342bwb343bwb344bwb345bwb346bwb347bwb348bwb349bwb350bwb351bwb352bwb353bwb354bwb355bwb356bwb357bwb358bwb359bwb360bwb361bwb362bwb363bwb364bwb365bwb366bwb367bwb368bwb369bwb370bwb371bwb372bwb373bwb374bwb375bwb37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_mse  _glu      _gln   Eval! " Eval"!#%("$#"&'%%) Eile#)(*,0)+*)-.,/,-1 _val*10247132156448 Easp2879;?8:98<;=><<@  Eala 9@?ACD@BA@E  EileAEDFHLEGFEIJHKHIM  Earg FMLNPWMONMQPRQSRTSUVTTX  _thrNXWY[^XZYX\][[_  _proY_d^`be_a`_cbd^cf _mse`fegimfhgfjikjlkn Eglygnmoqnpos Earg(orsqtvqtwrsutrxsyvzw{x|y}z~{|}~~ _ser t _lys  _gly _gly _ala  _phe  _arg  _asn _val _arg  Hala  Hglu  Hasp Hleu Hser  Hala ! Hhis " Hleu    # Hmse      $ Harg( & !"$#% ! !(% Hser '(&)+&),/'(*)'-(.+,0& Hleu)0/13702104356448' Hleu1879;?8:98<;=><<@( Hala 9@?ACD@BA@E) Harg AEDFHOEGFEIHJIKJLKMNLLP* _asnFPOQSWPRQPTSUVTTX+ _proQX]WY[^XZYX\[]W\_, _ser Y_^`bd_a`_cbe- _leu`edfhlegfeihjkiim. _thrfmlnpsmonmqrppt/ Gala ntsuwxtvuty0 Gala uyxz|}y{zy~1 Gthrz~}~~2 _leu3 _asp4 Easp5 Eile6 Etyr 7 Etrp 8 Egly9 _cys : _val; _gln < Bgln = _thr> Gleu? Gglu @ Ggln A _glyB _phe           C _asnD Hile! "E Hala "!#%&"$#"'F Harg #'&(*1')('+*,+-,.-/0..2G Hasn(213592432657866:H Hala 3:9;=>:<;:?I Hala ;?>@BC?A@?DJ Hleu@DCEGKDFEDHGIJHHLK HleuELKMOSLNMLPOQRPPTL _ala MTSUWXTVUTYM _glu UYXZ\aY[ZY]\^]_`^^bN _ileZbaceibdcbfgehefjO _procjoikmpjlkjnmoinrP _his(kqrpsupsvqrtsqwrxuy{vz|w}x~wxyz{}|~Q _ser sR _valS _proT _ala U BvalV EthrW Eval X EasnY Barg Z Gleu[ Gcys \ Ggly] Hser ^ Hser _ Hmse` Hgln a Hala b Hleuc Hhis         d Hasp    e Hala f Hala g Harg  ")! #"$#%$&%'(&&*h Hmse *)+-1*,+*.-/.0/2i Hile+213592432675856:j Hmse3:9;=A:<;:>=?>@?Bk _thr;BACEHBDCBFGEEIl _glyCIHJLIKJMm _aspJMLNPTMONMQPRSQQUn _ala NUTVXYUWVUZo _gln VZY[]bZ\[Z^]_^`a__cp Eval[cbdficedcghffjq Ecys djikmojlkjnmpr Eleukpoqswprqptsuvttxs Evalqxwy{~xzyx|}{{t Eglyy~u Eglyv Evalw Eglu x _his y _msez _gly{ _his | _val} _pro~ _mse _ser  _his  _gly Bval _asp _phe  _his  _pro       _gly      _leu  _ser  _gly! " _mse"!#%)"$#"&%'&('* _mse#*)+-1*,+*.-/.0/2 Hgly+21352436 Hleu36579=6876:9;<::> Hthr7>=?AD>@?>BCAAE Hala ?EDFHIEGFEJ _glu FJIKMRJLKJNMONPQOOS HmseKSRTVZSUTSWVXWYX[ HleuT[Z\^b[]\[_^`a__c Hser \cbdfhcedcgfi Harg dihjlsikjimlnmonpoqrppt Hleujtsuw{tvutxwyzxx| _his u|{}|~}| _gly} _ile _ser  Harg  Hglu  Hmse Hgln  Hasp Hgln  Hphe  Hala  Hala  Harg  Hser  Hhis  Hala  Harg          Hala   Htrp  ! Hala ! "$%!#"!& Hala "&%')*&('&+ Hthr'+*,.1+-,+/0..2 Hgln ,2135:243265768977; Hser 3;:<>@;=<;?>A _gly<A@BDACBE _ala BEDFHIEGFEJ _phe FJIKMTJLKJNMOPNQNROSPSQRU _lys KUTVX]UWVUYXZY[Z\[^ _thrV^]_ad^`_^bcaae _glu _edfhmegfeihjikljjn Bilefnmoqunponrsqtqrv _ileovuwy}vxwvz{y|yz~ _prow~}~~} Ethr Egly Egly Ehis  _asp _ala  _asp _gly _val Eleu Elys  Egln  Ephe  _asn _tyr  _asp _glu  _val         _ile  _arg ! " _pro"'!#%("$#"&%'!&) _glu #)(*,1)+*)-,.-/0..2 _thr*21358243267559 _thr398:<?9;:9=><<@ Hval:@?ACF@BA@DECCG Hglu AGFHJOGIHGKJLKMNLLP Hala HPOQSTPRQPU HleuQUTVX\UWVUYXZ[YY] Gser V]\^`b]_^]a`c Gthr^cbdficedcghffj _leudjikmqjlkjnmopnnr _arg krqsu|rtsrvuwvxwyxz{yy} _pros}|~}~}| _ala ~ _phe  _asp _pro _val _ser  _gly _thr _val _thr Gala  Ggly Gthr Bser  _ser  _ala  _leu Eser  Easp Egly Eala   Eala          Eala    Emse Eleu" !# Eval#"$&)#%$#'(&&* Emse$*)+-1*,+*.-/.0/2 Eser +213572432658 Hglu 3879;@8:98<;=<>?==A Hser 9A@BDFACBAEDG Harg BGFHJQGIHGKJLKMLNMOPNNR Hala HRQSUVRTSRW Harg SWVXZaWYXW[Z\[]\^]_`^^b Hglu Xbacejbdcbfegfhiggk _leuckjlnrkmlkonpqoos _glylsrtvsutw _leutwvxz~wyxw{z|}{{ _lys x~ _pro _arg   Eala   Earg   Eile  _arg   Eser  Emse Eala  Eval Eval Egly _cys  _asp _pro _ser  _ile _mse        _gly    _tyr  _gly ! Hpro!& "$'!#"!%$& %( Hval"(')+.(*)(,-++/ Hpro)/4.025/10/324.36 Hala 06579:6876;  Hser 7;:<>@;=<;?>A! Hlys <A@BDIACBAEDFEGFHGJ" HleuBJIKMQJLKJNMOPNNR# Hala KRQSUVRTSRW$ HleuSWVXZ^WYXW[Z\][[_% Hlys X_^`bg_a`_cbdcedfeh& Hlys `hgikphjihlkmlnmonq' Hala iqprtuqsrqv( _glyrvuwyvxwz) _leuwzy{}z|{z~}~~* _ser {+ Gala , Gser - Gasp. _ile/ _asp0 Eval1 Ephe 2 Eglu 3 Emse4 _asn5 _glu 6 _ala 7 Bphe 8 Hala 9 Hala : Hgln    ; Hile               < Hleu        = Hpro                > Hcys             ? Hile    " &  !  # $ " % " # '@ Hlys  ' & ( * / ' ) ( ' + * , + - , . - 0A Hasp ( 0 / 1 3 7 0 2 1 0 4 3 5 6 4 4 8B _leu 1 8 7 9 ; ? 8 : 9 8 < ; = > < < @C _gly 9 @ ? A C @ B A DD _leu A D C E G K D F E D H G I J H H LE _mse E L K M O S L N M L P O Q P R Q TF _glu  M T S U W \ T V U T X W Y X Z [ Y Y ^G _gln U ] ^ \ _ a \ _ b k ] ^ ` _ ] c ^ d a e b f c g i d h j e f e f lH Hile _ l k m o s l n m l p q o r o p tI Hasp m t s u w { t v u t x w y z x x }J Hglu u | } { ~ { ~ | }  ~ | } K Hlys  ~ L Bile M _asn N Bleu O _asn P Bgly Q _gly R Hala S Hile T Hala U Hleu V _gly W _his  X _pro Y Hleu Z Hgly [ Hcys \ Hser   ] Hgly        ^ Hala        _ Harg                  ` Hile                a Hser    " $  !  # " %b Hthr % $ & ( + % ' & % ) * ( ( ,c Hthr & , + - / 2 , . - , 0 1 / / 3d Hleu - 3 2 4 6 : 3 5 4 3 7 6 8 9 7 7 ;e Hile 4 ; : < > B ; = < ; ? @ > A > ? Cf Hasn < C B D F J C E D C G F H I G G Kg Hleu D K J L N R K M L K O N P Q O O Sh Hmse L S R T V Z S U T S W V X W Y X [i Hglu  T [ Z \ ^ c [ ] \ [ _ ^ ` _ a b ` ` dj Harg  \ d c e g n d f e d h g i h j i k j l m k k ok _lys  e o n p r w o q p o s r t s u t v u xl _asp p x w y {  x z y x | { } ~ | | m _ala y  n _gln  o Ephe  p Egly q Eleu r Eala s Ethr t Emse u Ecys v Eile w _gly x _leu  y _gly z Egln  { Egly | Eile } Eala ~ Ethr  Eval     Ephe                Eglu                     _arg       "             !   # _val  # " $ & # % ) $ # ' ( & & $ + _mse + * , . 2 + - , + / . 0 / 1 0 3 _glu  , 3 2 4 6 ; 3 5 4 3 7 6 8 7 9 : 8 8 < _gln  4 < ; = ? D < > = < @ ? A @ B C A A E Eval = E D F H K E G F E I J H H L Eval F L K M O R L N M L P Q O O S Eile M S R T V Z S U T S W X V Y V W [ _val T [ Z \ ^ a [ ] \ [ _ ` ^ ^ b Easp \ b a c e i b d c b f e g h f f j  Eala c j i k m n j l k j o  Eile k o n p r v o q p o s t r u r s w  Earg  p w v x z w y x w { z | { } | ~ }  ~ ~  _thr x   _pro   _mse   Egly   Earg    _ser   _lys   _gly   _gly   _ala   _phe    _arg    _asn   _val   _arg    Hala   Hglu             Hasp          Hleu                  Hser               Hala     !     "! Hhis   " ! # % + " $ # " & % ' ( & ) & * ' * ( ) ," Hleu # , + - / 3 , . - , 0 / 1 2 0 0 4# Hmse - 4 3 5 7 ; 4 6 5 4 8 7 9 8 : 9 <$ _arg  5 < ; = ? F < > = < @ ? A @ B A C B D E C C H% Hser  = G H F I K F I L O G H J I G M H N K L P& Hleu I P O Q S W P R Q P T S U V T T Y' Hleu  Q X Y W Z \ W Z ] d X Y [ Z X ^ Y _ \ ` b ] a c ^ _ ^ _ e( Hala Z e d f h i e g f e j) _arg  f j i k m t j l k j n m o n p o q p r s q q u* _asn k u t v x | u w v u y x z { y y }+ _pro v } | ~ }  ~ } |  , _ser ~  - _leu  . _thr  / Gala  0 Gala  1 Gthr  2 _leu  3 _asp  4 Easp  5 Eile  6 Etyr   7 Etrp  8 Egly  9 _cys  : _val  ; _gln   < Bgln            = _thr        > Gleu                ? Gglu                    @ Ggln     " '  !  # " $ # % & $ $ (A _gly ( ' ) + ( * ) ,B _phe  ) , + - / 6 , . - , 0 / 1 2 0 3 0 4 1 5 2 5 3 4 7C _asn - 7 6 8 : > 7 9 8 7 ; : < = ; ; ?D Hile 8 ? > @ B F ? A @ ? C D B E B C GE Hala @ G F H J K G I H G LF Harg  H L K M O V L N M L P O Q P R Q S R T U S S WG Hasn M W V X Z ^ W Y X W [ Z \ ] [ [ _H Hala X _ ^ ` b c _ a ` _ dI Hala ` d c e g h d f e d iJ Hleu e i h j l p i k j i m l n o m m qK Hleu j q p r t x q s r q u t v w u u yL _ala r y x z | } y { z y ~M _glu  z ~ }  ~  ~  N _ile   O _pro  P _his   Q _ser  R _val  S _pro  T _ala  U Eval  V Ethr  W Eval  X Easn  Y _arg   Z Gleu  [ Gcys  \ Ggly  ] Hser  ^ Hser  _ Hmse   ` Hgln          a Hala b Hleuc Hhis  &! 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