\!3.6-1h%/data/swissprot/ 3OS6.pdb3OS6A_ConSurf_DB_pipe.pdb 3HWO.pdb4[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Putative 2,3-Dihydroxybenzoate-Specific Isochorismate Synthase, Dhbc From Bacillus Anthracis.[/h3] [p]M.J.Domagalski, M.Chruszcz, T.Skarina, O.Onopriyenko, M.Cymborowski, A.Savchenko, A.Edwards, W.Anderson, W.Minor, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3OS6" target="blank"]3OS6[/a] [small](deposited on 08-SEP-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Consurf" --] [a name="5" href="#_"]Consurf[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Homolog superposition" --] [a name="6" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3HWO.pdb3OS6 a_3OS6B13OS6A_ConSurf_DB_pipe.pdb3OS6B1  3HWO3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iᅩ JzyBJG?WO ,U7,w`ٲ6N,m n;Ezc_7N~Yxt}ҟG]qTHN ȔkUtJho.ḻ/zƉ($'MޡX}bU~x uԦ={}'m'mϔ*0ߢ̘}<4;7ǴZ5^_RU׵iS6j:eN@V TyhfJ~" -~J\ˍ0T(Wb->-HʏmF݇858X+aSU> ɫ&&2KR>Kѹ s; ͝>%%if6?cF#դ\ E:Y;z&qcbb"8uxLiTAB  ֧( lu9q:Nųx+>ڒSw,z6NpW\4^%a$d |X?vpM3y\JJ %ռlYbjtBN6meM(v(+ey@ueg[[Sne&) 1ICe # vn2|3_ El]iʉowtWO4+oJ]IT$VS>?]E'6E<OG" Usr} d%I?jiDȧֈopqv_2&JUsѩNɲ0*.c,-e;$'-Z+oVK6meɳJv}5k qrPz Ƞ&HGџ/ug?W<`f&A H6LB@yKl3R'⤳=؅n/gMݎ&MdІI88Z{w_ۚk`W7ncfF5nḽ\Z:\ӪM[SlɍWk\g{6+?AŗwƯ dXwNm?EFM^`%TYfYYX;Il~KDL3rͱjo/.Ȧ'iJeةtOʼnQyCN;yE6qxkV ̛hmKN;w;>>X[p|25"X?|1̏1}.Wm޼DL_g|sH77ȈNU(|:O1&NK;/>؀~/~&}snݸƁ}{>9Ofm[QF5mXj7GZpcuW_ħo'wi8Cw;[8CߛV7<` _p8 l8@q{?ߞӰvt/\>[ mk =Q>Y77͖/>gi5_|55}MH$̭vuS?͉~U3~9]{7kHh02=Ia38ΖI'>]&u;3ޝ9 ߽VʣYea!i:]=s_PzD\f$gwMQ(sI Ό@R"F:+nZ~QvX0^})}%냙2çd}͚0tY%εSIE* :uhؐ.Y|08 / ~:Ņ?&k?G<{wϿmn ? .9: ᗷߙU=;Ko{_3ݨS9 @2pDΡ; VVv A?vhPh!u 5Ԭ 2}{-MJxINV;U=lTe^*=?-R<Qbf-Ȁ_4TƁ|򙱱,X>{?yd{Uk p6Ƀiѥp'䥧j댌4Ja|؉s7.eBK?1$yX0{?} %y*Wƀ-q_'~߮_Gf|}QI43#q̍vmogoG"zˍ Ouh؊C{ڿ8OZ8lMMԁc~36i@uyFFԳ>_66s}sҜ[N뤫< G^eщ鯇ɱdx,MmeE=SS_7Qo}Ƴ`y-!ܷ×Ft6p oOh -8^,jIk ߟ˿GHչ}osUo{|~5=x|s"_@K0w]G蒘A6vԪ]zV{!W͇ോWpoǹP~}N+< 7G;/}׌ƣG 65;V̿<GCbhܬ%Οo x qu7yN3KN8V\+}w@*ea!ZPh5OvVVv$|li\"A QwWE1mG7I[- ˕_>K] v+Z%azJʋk˶ը!XI @Z.b\|YsaHFdfqHpL 2`K3D&zJ_Qdk>Iq~n9+ix _UA xB=.i+00ủX<`ytb*?dɒ%N.ҍ % jq:duZzvM\ֹtKVшACe:) UU[ۙ߀G66@.\U*1[7e+׎Q(L=E#A<ҩ& Ry6I.jE) @Vj+>W9n6k&/q7s5kuss2UIzGE^]QF^(rd̯SI00oaUS!*N?j*j.ς2ĂkP/_of&DtS  6͑odWPj52W@Ey[QB]LX)^x+r6mN{IĸxYw2~K%EF5΀ |t~r e-Ӵ\.f_5Ž\Q߹X~6jtsOȘ5ƔX¡/ūi{5lHu11f-ZnbnN^^O` j%ScccժNZ5VF&FM2Сۚ[?zu~#՟ #CgWW9DQwA*ŦV-w-1 @~,>1-K t̑U%*+b?8rҬR={IS%m}]"{*B'} pg8~f׭uT J:fdv(O<]&]{`Y6L=;Fv,r$O*ֶOJ6a["Tg tU.t Q'=}]\n{Uk 'Oh1^&}ع/ES72ϯlOm]$aA͜PJ[+_G9gt5WM/eψM>iaY4f/#>TDˊX]*ݦs7PWmE7x8zIA2.g$ kӤ7Ü~^{C A6V[,nZY$~Yi| :EzxI-rtU;9Lzy ڸHϴ1~=‡AzeQ-("ţyYV'=eiB/K"y$?-(QSV odyLk^(v3@J$%2%ᰜg*X|*:iCcr7Vt[U,%; މEkK3YZc/ıH%Kt|Q}O=a9t SJ 2fZ\Tmںxiөc }J5 4Xf2nj4Tm&YR:ˮj_Ƀ@'NIJ}T`dSܢˣPrƹ≤)9nrkl\87$ƏoĄp/[qMn^N[`ddDk/;

mz ˻/,OL>pFn# mRp FFzi!vlaX n\s2/5TՀr\Kú+WOʾG4hMj 10$~?W Z2ưqUwAT{w*mq oX:JRFJ8G{KHvr K;Eخc׫'ڴbsMVXXLl' H;7o.zug" wz0lM7(]ŲP3Bs|_Kkf&aZ_ɩRuߜ~s@uanrctNcY ugޗ-4i_-(P8y4i^fzUn2p8@3* =bý?fr`i zu2^ո1=6e_tX6H[cl\}ÐܫEq~bM5c8(^v }a#cq:!{p "&ijGS?poG#q a&tАvซ{*Cb$dXw=Mh^¡1Aʱ[B{{Iwu*i*y%&(eSYo4U>tDQN(, ?^Y1WV|+E6I}Gʫt1ldO .flz*FP$$%kX<4! |࿭͏#ѕOW_-ݥڙV/6SNܼzb~Xjat"tӊ'CiUׅ#Vq'h6$ulnlo;_hmcɠǕ5YƍoyN;Jn`Ⱥ*ylxA#E/tZ%~P,'jb"a#{2;kנ (%=7Ʀ&c;YmF*yyzyih[5GǛL6īۤW_Iqرf#(buperׂOW2ƆwZ`ϫ_hsA=^ \8yc;kJ nRݔ/l}ONo99^m=&Vij;V Jәs!ĝ^|xRM !7'g|;;.q/̯fml#~X9r|=a0})?ڍ7eӟ*Ϟťn]]Bi '+{* jؐ,z=#"ڹT{l]˔Ԧf8E!b>*MU5!⻳ 0Y| ?7Vu>K7۽[YC9թ#$HE".)Ixh MqI ')e/@q`P{|8ܼ|ۚsmwNwkmzj!WG{U~ yc~VKXڹ%zppp`tϞ/7HEYܸx+_o֮ͩ7Ym?ݚ6ez8h AV-^nؐ(т'4o[bу8zp+fd+6C}Fz/K8n\j$^"v cS#166##%сОXhj '@M88zGan^Nd7Ԉ?'Xfضsddzxc##8A?R/D[3 [ׯue~-oĞ/=įal /|Jg93Z8Yzq 1"S˘ \/ʺLFF>'vC(&ȥh&x1E-뺸Upp6U~>-eNbbZp>'cێg9k+Q-Yɾ[Y6?d33f;FQŗ o)@uggIT0d 2"X迃-ke1Ou6Nc% $E+E7 ?eݺm2tyHcU 2 ZB6xgS,EϹ6PQ5w8ɀqb5.T68{G ϺVdhtqwWLqti4aU>BRJlVuVLOlUKi%SA1MǓ7 Acm~̒}ФMM3H0^6YlP{ಝOPu[ku=:Ih^(L\ҷSɆ>KG1U$vud:{^)4 D.mjo@S:`&2-sl{IS ˇKQx&V{$Vje]RdpVҭiS hPeN} bԥzew/3 6Ά?M wצu=yw~)ѓ$!uhzs֮r]$Jw,1Xn,Nڷ!5X8H5g)zm -?tPf+/X\ s` ˆQV ro?[j1(qHJiI+Fڼ5:k R /0Q|ljq'^k7$;o>fB%G>{@ tdv=f$?/|I[<;W~@ǡ]U-|FpBiaݢIH~]qgOEY]We4ʧjHڍȡη{HI0G~,Htc.\IkDN{g'#ʈJSm]R"9"L$/,Ԩ_*awG7n*aPGڽuW,#"zu. a.ά)%Y$m5 )Ef'cɢ'E G3p<,%dH jw4w<0,ČrO̜,}ˤ+ԣy\}Mu'wiu+ UG"mԖ=%_Jj; Ԭe!g0UՒ0k{v},*B2EYF)D99= (Q Ec..]mF0-uW~C{LE?{C2Dt`(0 ~m+A6`u7%5}-Y6m3R=hfr1||w*K5,~wp+Foޭ[xӘ|a3@3Bw Wզ6JP]:AJ*>WcQ|$q׺DOQ>kFV$FvWy6eSd)PA;@A>S+|VL(=^DCo<"WCA@w,MUl-&G۷QKcKGvf',jP^Ebhæ=8eGq&vzN<jJ@͖{{ImRP/*~"/DGJgq㉗T*}@עefj&^zUͽ̃"dl`=MɾP)-۷5Xn]squU+@^75W6Uagdn]3Z|49%dXw H+z;TA/W᷃e} ]djI+GHR)}Juq2#Y~I介 `tg#~yR) hmH _EX'/p̌4:]3*z/888*_nM)2}1*פ^;G_vwF(7Ϳ|EǣGv,j('@|4Fe,m~ٕ Rۺq]Đݳ<"X6gtpcb\ŻƢiU-tG$jRl)'GAwݷޠx6Ãl- ̈-{6M}nZ[Bp(%|vfʥ Kg/|"+ӕ-pHf 77zpzt#yl$˕"'f,acT4ŠRЇQ|ZiAb]Ax4CK?e~~gBƉ%nP:祳(\*~3*z$iu:^a{M:u]pu\96\cȅ"pZE;]{$; ttgT.V'5SVpco>9NxN\qrГ V|OaʿHwl2=X:2nxG$P K [0{9db5P!B^}qT(an}R*{ W+&SGby>ooPBۉSU{^]LB^hE𙙙lXfUxgx_es_^el1`:0Ⱦ׃ v[x)U>F єv?S5LdqAFfe *yᆇ.z<8Pmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???tt$??f1@HCR@?@Ȳ?@Ȳ?@Ȳ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBiological unit|,PNG  IHDRc IDATxwx_B"-RIB:镄$$@$@(Wi)*JiJUDP(J*J )lf7<ٙsϽsg̽Q2LYUw@]#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d/aѢre2 gʞ<(T9:&r(Hܗ߮]gݠUݭr!?y\gވJǂUݭ Ao W @5*} *k9TOS気D>b ea#gM3P$ڿϡ g){޾g4Di#0O12"`Νri֬Yտ 8um/ەgu\^v/cڑ!nq*<UE*1FqM%b&g./dT;/̭\>߆"g$ʩ=)]DMH}ήsya@&0I "}ޕÏ5 V^G@VJX2cT25J'tD"+2g3 D9n~a4lT6n\-kLnRlqtvUlm&$$ WFhy ֙܉r +C^4f "*%D` x*ϛb?8ξ}wɝTQy3sPujr/UX E* s @t!G% Ⱥ "cNs$)[2V=Do)3x[zm}DS##Fi/ hsu1P~mUkYnU?ut??ZQ~"~~}ݮBd pyt gm)xJeɗݓNyUVfZ`e™L)߷ x[{n]Ϯ{w!V6sv; Ȯ)ԽV;s7qY!A$y){Tzj^[%?h?On-ɻ6ޒ^~!W^exݻIJU{;vŌl ZOy,5} RPC0~%fffoW. (˧0B;a͊a&yAz* xfA_I?@4d#i'ӉppV͗W =V_p 0IZ1>{Nӆ/#b1{ 3n4WΉR%zR;g3Z(Fs=Jʕ爩Y0`ffJPqmP+OdRo<ffea=K{?S(;iҌ "?dP7%(@2/z; >ƽ1 RɃws&k֢3M9lZbޥKt Ŝ"ڇoY2q[͠tyW U6u. úZ 0"*NQzѓ2D$C >W(ڵ mIp+@8@.")vz{cu]Exi`<=M<"dwԲH͝(<ӓ=dDkv{;-?`AM1êS@%v^f*U33Y'a.BdƧ{^>EYPi46Rd}=0iB$6m*+b_))4sH)SxC\كꕵv58cgO^?wU6`vC+~9=ƔS%U+m]9}t?ϵ }ͫYrdWkw/@,,Gpmd*9?=9={Q. r#>q1/icOK}sss$kk</p_D;jc3P2W/ʔNĤ(8,QHZ =[L;`Dݳ?ʾ #cBo#0BzRxW`uL sppd]!`P \JzZa@ Jv`}V6lgePV+͆Q8Dzpy4W־}d|X_.+s}â|Agr#_L|=a#( B?w:*A)(ʫ= wo^n"/ix9sΟ:Fi!١J.i0W`oϑ1B}LɴpnWomWq[J%\ @iy?\<3Mk'10~ѯV-2+tӃjq1=|93ףժAS4†':,-POxu7+0xcr |-<[Nl?sZٻ.^DZk~yxeԙ;w.gv}f b+2=rBJM w `͛ 4x-Lmi)l:=wsͩsR *u@l(ǡI=:}"Èb%l;]o=AQè-_$:u;uҖe.)2ѷw:O>xgNٝEɥ^ILCW©vm1J iJ[5'KQn@0HkL8x{& /*/hN_jv{̃,vGB?hԼ+.ݼpm@ƼSf_ʕ0D)O8_c9(5ks<$} zu -ͱ Հ;b^$d ȓ%[rt-k>Am,DeizɺT63\aP+o0p@\\\_ƍWpa"ݻ^;|'[ݺ(X3Q1A14"ޯ< ~&M7lѶxL>*ʝ{&mI|qSz03#tx"]&Jh|p`mMKKKo[Wk[o?qWHiܸ~U*̤W+Xtvd,Sߓw>m1W%;ymɿdɒ%<HJE 33n;5CZ#|.; {gd'sFU̱,=#>fxXO0n$[է>>S+K|'Pvs->|NO&l|g.Ζ|XyFZw-7npoG%3Mjέbʂ,`;>a]y6Ho֌>m|d/L:c ]蹗DOÌER:|b3<>Q\ D@myPLvAzuggda!5k&ւEZ.~1A"xpDr "FڀRϧre鋆mDkt( 3 @_5;rd38Ϡha.  ot.GEiubwٳ' ί~م5imB3v pzmi |]uu 3s{H3EE;O _szjԩEͺ594GHoxV~e}wY^DDR6J^C[(T+}ӠkeGiyx7 O`a^ZfZZg_Q6M|h5.ߠ[F\ODy4 gT/h\ -:*iQ"-P)C3@-ڪ- ]7ڵlM+P`q"J$?6১c1zƁֶu־5Bg8v>y-ڻbc @f9;wݢUTK^̪kp[S);WMy 򹐗ǬY^&= )ퟺ0i #r0Z dfֶ߳ vn>XZT m$ ҂)Oa^>"^֪TLTՄѾWB[l P( G1HkPv v C \Ѝ}º|r7GJAAzuG%gG ֥?8 FXYQK1uTrHY͛븹?;׹sٍD8دq7"nS}b ;'#J\N0"q^Nt>"mBw?ϵ|+]+-WCY`8yQnݺ1b鋔CDka)uۇkߟ{sCzXrHIM9| N),(z.[Tsp`mpuOcz{Jwt~J-K[F qT9dω V( sp;jAY1Ψjֻڻg'Z,`H#< ,G&Wq"dXp[W4nlЮ[R["dHѾĦ֖wcjz̋SzP#}BDlHB@./"H1hK"wN\KG=nb G(:E$rƿVy\:J=\t7X$O$G$XuA"!"6oެW39Su]u^A©N1JOMڜp][ n(#}u I}KƯ_PMͷԲL'z"-YۻiAYP@fEHu 1oPn/B7T[ݟ}VRDG71c 1DRbGeSM*}+sO['IˀW=>c]ݣG0NQclY6BhФ[Vhc`EJT*9.϶g֭Vۗ+ ܕvi2u8ȩ#X SGETE==LIydQ8k5 "lcƮH;ZعJ%(INDb9mvc}C9X)B$;g7^C{`8D}?taHk\{@XX!wF#I.RZGr/y ׽؀d۽M pVUA:sa)Ba#.ƦR;Co`LM۷s(~fOfkl _:Hkpran_'6" yGrT \9~HqO_|h8'9iQJ]̴yٻ`'Jy~[وH҉ФI CtL,'iW_Y&I"jBH.bOnm'|#yJu48 #c8\vy\SҽuUn+lwڧ"vs)0= ^+ /i3hSDD}mۮFO\%Ln"d] $KqIr g&R4g6`,-bT1uKy&an.6>fcAxe 0 u,5!ӧOדٸqNQ\?Zńf5]RfsG1 5T*MLjHJ\k;Cy6T&Y&㸴/a*ڻ Ή"C4Eȭ\R[ ޜ8ifO)oDRf-]=p^1qh#NuНS/5A3 " =@zsK@liTlkbOUy>SGjX/Y gLHW4UYb]R%8)={8N\L+=LtL|A@iK|cNkDLHSUtT4(ĉCrJSuEplHP+`Lc< <}$]*6zĺbВܹp >;#LtL 9 "4iB|/2빧4$ OErKR;ɘިA;ԁc^F6h*mЫWZ94Nl9ȕ+WO>8;éSz(U*.T+GT6ծX׬B7۪]Ȼhs03SpdWz}s؁Ҿl"SɁ?<6˿^3aDڸԍD A :GgOjڔb+S.}{;Ty0pMtDV؅dqi}GcN||@Oq@lF ~ἣRȡvs݂9]hR*meW'?<^JW_}J\cSQw|\i`<æJ? h|RSS>}:`8xt>e>ԯU^[)*̯Ojm-h!..n 7X5jO/f ΍ߛ+Ih8~q #'"1b Ur'T! @˦Y [j(8eS~FeU)!5W땹[a伒_Z 73h¯/˴Z2n ;cņ9u̿ P`l wцʆ+t x B%Zc pys>zZ.9G+j5ٳg֭J,FL͂Yj|Hp|e?LZTl{>|=reuzE͚5Yt)"J~0,kX03\8p6߶hż<}eo2L fM$k ۶߯du[mȻCQq*iA-"nFV@q_s*X?"f(P)U R~B\UzmݻLI18QW@cOi܅*lkP.YwՍ,k#y붜8R^JC5`\q57,̎/dx{{ /wXBL`Ǭu-HUOۇ'aQ;_9)NZl4!ȷRq ^6Emhm:'%)YUJW;c2ň!hf($t^| ׆WϬ*B(.hwpCWFVz*@4߶Fq+e@H.%y.mp[-O+ŏ14X{XaUyJ >"kFcĄYƗKR /h5ޡ&y5J3TƿoZlB!69o:PD}"!O s4t7FyT!;zDC33LXܬ+9X<DbQ"!}TcoY弾5!A9g'ī˷h=Ax;tc];BMjA$/+ RsJreMx|OIH/ e'&O̓$_u>(SR4=+W ("e)Nkgy.EF/@ëz^UliFu& e5o.qAYlw{X┉~N*{[OB_!7jKy1Ҷ->HHE"REO5MAl'9E"m5:EW <źTԯBf pCː>IS['e<RmLҥ.x>R8nUO2j;Ɛ}[ZH2*{mUOxzQSu]#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d#d?,"GIENDB`move=1000;blend=1000;3OS6B1g"  ?A??Ȑ@d@I?CC H C? CAC?'A? iUQDjZZQDj֠?֢kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠?OZE@GjOZ֟G֢֠?TQUZj#'TjI H$ $I H$ $$!! HBBBBA$I$IA$I$I $ t,]m%!pf H5DUjDUDI$DDAAB!B!A*UQjJUI$DDUUTI!B$jjMT" U@""BUUU"*TMUjI&$UUDDDMUUUU@DFUUUI&""&jjDj5Q5Q$UU$h UUR@ $UDUj** vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6+?1:?1g iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj OZ֟G֢/֠TQUZj#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB#% cBt,]m%!pf H5DUjDUDI$DDAAB!B!DDjDJ$TDDFjjDj5Q5Q$UU$A!B*"I$$UUP B*DEUTMT@@@UUUUI$Q$jjH HUUJ$TDDDTMPdUDUUUUUUUU&$TI$$@@$$U IUPI$DUUUTMUI&&$UUQ$MUDDDDTMTɪ&*MTI&UUIUURI& UUR@$UDUjUUQ"UUUUUI8UTTI5Q& *"II$DDD@!AB!B A*UQjJUUUI$jjI*I$BT!DI5TI5Q&AB "?vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???$??@p=O` Q@?D?D?D??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residues:PNG  IHDRc IDATx]wxm6iYIӝ^Ȇ"{2Td  q "De([&)zO^ D~<; |oycu !#c!ࠠtI enɇfl*22FR(I*M!(ؠL@ry t4 rr&ك()2j[EE%"p&ݺdŅΤVIj$䑵u wpJ֡Fx:8z6rrz]9SBJ {{o6(okA=I,NץI$EU4 /}T dcӖ;6}h<PWWth~x@H!\Ɲ;GQYd*+ms*7nXk~={ai)d"ܿ>A 87dp~ ~ Je2*QRr ;P W B8$yLENNLyEju$S(4t" )gmASoAMAr&%)|CHJ~~cH,N$wM Vc{sKOg9:Nׅ%1$u'Z4 (!с>HDJlrt|4*WHD|zmp0V;ؠ xRJvIH.O D;, 8~vv>07ҕ&R _"xŨ|0$<BA8q=PȐ쌕W`i-VX`%Ξ݃g`-Š @Ϟw/QV&{ 7nի4 /,,[ff.HL`g7 +ʇy>@A_((pƃyޮ]Ɲ;!ƦѾ6m52x::b#6(xS̙ >:.GG[ [03 Fe]̯S{2{e"ѻ(/?>_ӧ Q^~.} (-݇{**{\r|Rk뮸qcѾ6< < CH]G2/ҥhnV/MCNNq%bh"[lrDPZ- ) gB"!x=QUUw'řpsnnG`cc '֑*0摧a.!!U5|f+VL t3/Àݯ/-Zϡ'aw0}.7EEPQ 07npaH5]+p|H4oFW httED@]cyx$ZݚS}iiG'/L6=:RbbnMbq$-~MDt|㳂PtD[HM Ơ}..;(* $-4#׏GEрxF7a]^T$]XL}i,@doG(&&Ǝ}P&ԠYY^>nՊZ$`3 @aac dL-Z|㙛;UԵ>6y#';G˗t4׮ԅ?*(B݁cǾGjjCa~7p8Rح(+ a͚.CpJ,\L~>ZTܻW Kr刋 :񭪪J05.^LL^N!64y K9(!\ ||RΝx}$]ć\nTUƍ׷3{n+TVV̬1Nn > ,,pt+toNN矝ѾX;WFmƍ?!YP=O#۵CV X_ⷿƄ |+cڦMWTVjl52,XCjUi#r!q>RVsfeK#:zVކm۪myo`ǎ^b?JJ>~8|xHfw٬#Sصk%_H. nÏ?~S#{\_ /Gao.w Fi9̙|y*+PYi(+ ;M̬ "(,r'ҒBWxyByy\rr:ԩP?Ž{+@5摧!05ȑua99qM!,l"@]{C !~{L_ _!}6ᑨݻiݻ[!䠼R>~26AZ(-}7n$>}=Mի()CUUv8vpz; 7y?N -M}0) %&⑑(ח2CFm%*LJxf)?ȏ1q KD?4ZJLDm j o)2r$$#9ޕib0# $ۯa@'u&$D bbNXS˓Zwg(+k5)zPHULJPXcT"[TK#(..sz[/~e BCRvQnqBMe5$d`lI 8s#pRR,œq&Ρ()ck8~|@ xUUPZryGhaff UUxM!oȑ p K~ χҙS kC{]+?D"_X#@og.M<2Z 2 ϖKoLL*.]fRf0rc;NNSM34",€fila2޾AZZ\AZCrR(/>8=q[Dߑ\ԼgXp~8%ҥs>UTdś_ƘIƊ{x!3 xGF:8JUN&NRTrpHJ%chg\*) bfꞑAmhȑ4Gkz \nICmlpFO m/ߨ8$?9'*yl+*p0شX<UU!'ON:st/q|xrӰ`6͵x-$Kbqė`mǙ3Çn6uA{j0c.RЅml"4HB. ۑM M))h^Ϟ ӃKE..sq[DA:&$GE&\]񉠖->qߛw!?h?f<.\\pH+p *(, Iѕߐ9y KoCM?3`coP^~>>k1|NN1ml\.^}K:gťKg&>O5ֿ K\n, ٟH^&GǙ$ͧdm=&/|}GQDeNZ*!npC]PPtP3s"[[jO.BBarCyGkgS۶ӊ?Dr;z$I"9JZe` "#1p=OW׽>#'IBj7H?Dґ|}>iߚ>oTv'_Xi>>L{{gm $ZD:1nbcJK~~i&Jw~/Mj{ 5ijٟ_\ բM&6eCLE!!-Xi|~+rq_x2H8gO>cD8XE^^k3:tHHtXegkkK6RS mn$S9ؾ>qM2⃂բv@ŋ1g R⋂Q]]7~Ev=8ztQ>[ 8Hw6k TTT9&LBuu)_g5Gњ/6SN0Rh'18:oY[м6N0FA0:֮II۠6}ۛ٦egn&ܜ&%ц0ZUےa+I߰1lݺ5%I;kfy>H,<0 %KV{M ||r(% ::tx'sJoy4|Gڤ_MM:)Aqڴ7EU8pc~F(ع&n߾[.>ҒX;;Ξ..]^>>i8s[V̙oW&Cgg1m⫯6=M3I'Mlf*8t2Pl{ΘWuR^atGEG1cҨQ{Y]G/)1:4^^kYq,F[QLw)6ޗ޽OzNl|6 /LeFf|Z0~bH OLV\._L|~-I$jC xrqiei}yyusǀVg&IQ]͜+++ 袣Fy9B/ۗU6DDѣo/WY4C~} ڶY2X4..m:UUز.=3s(,kvT_F8X]\Hhr(3:i ㎎Զ)rv@II$Մᔙ)%&?-Z0s}zNqqa6էM{z,E#GnǼ\\> CI&Զzc ҲVM5an˩c7k0:t_#[Ye S(7-^Fx 22OPHH;jVBI==)(K `N) ۻ.> ;dd Tɔd8i$l$_]o?zXDaao'c rd2 YJџ<qsјӶAOmV6z]vv_nhNVVT "ޛ23_e=:b709(bKF== zۏhŘ14^&3jSdvZ`iKkjq jMΑ#YsuX,~!EΝ“ᠲ.&|_ܽV1Cg7m?ڵc--]07ì8~1u֮|檥ZoO\W9:"\Ƃ榟̆fZ1 b9;OBQQ#0q"^JMl7m[mYY(((|ss?{# 0*W$L98'WJv1 j~V\ξ^&{==6(iiPmx4rkh^6hIΌ4\\tyZu9 yԦ&qgWRH(d={.3 \[X? Xqr0iTv M^M h&[Y0`dLxxsD3f|H,NfH[==kF_VM-,,|&^2BB|pn,:x}>MY4ܸ1 C\Rd,e 5'?5Zt<8:2-Ѷm'tV-Eqv= BaϘ/Xَo`Mgu됞 oB~wpp|eiYZ:LCQVV) *A@L\\<ak[-._^rǠbWA~&vXY^(,pp苠o24l3@"Y`WPo 2mو_ncݻ3gVʤe  }1 ΞR&u25iSRrz} MIjӆjck{y>\KͭXՓ=qaDa~2ZphKPTVCee1_6oJJnҥa {h \]sp9?xJ{P n'O>.wptQ6_D>jC _?>*>vwҤm=۰P"JHK?՚[Dido?XHdnރ|}gK3$.֋;P`!RwM~~闟~S'NԛD|~n̘Ք4uiC(BBp};9]&K wh#eBBu{5jMHB"^i5\\\BUQ!sΔV#F:lm'R('UϢV&_OwRΌ_H,Kb$ n4_ ȤL< 4p :sgEק2N 4,ȬYϦg猚̘HDlSg 0DÏO޽Aaa[x#хvcDz$dtuSI"1Aڱ`I 0~rˋ=B$SZ7< EɼXg:are$(.8 Yù:/fpta,-an΢K>&4ϴoY@ J 񘗮JNNCPUu6L->B z6^d T2/6a*`2TTL?@Ϟo5kp꧟t+Wv]"ĖonTVL -sZG gvG(ɠlUU%  =pncƌFCh}/tNm;г:y> -ZG~;0U5ppw9s7QYB]c@`ǎ?(QpqQ)|p'B,vPڰsW+oB:}?n+pjG})*aeRf)׮1 ǝ;cjEhh8?KK @˗?^'ݥK1beAmW'ӂFJYqZ[J$܃˝M\zru=E\5AoI(CVVI$2T ;p3ٙ`e@23vu5(~=sB3((_%yxv(ߟ44pÁ1$d%$0Z CWyf{>[~~싽,,B1'f]q p8EFlg(6gO TbJkkOW{x}픖Gq*/Gi)chf$zB.A SǏk7kސ!eet­[[KAR1+.A Y[Ǔ\%W.J2$^oţK m{e2Y"{e4g`i@lhj̜ǀcc7JKcF3:*71j"[o璽}MHObciaԧ֨\ i; hp16 yJe299du:tI2xrqa;󙥼@G˖)9HB]X,[):: }|7wx(2r:+mT/8xegD(m.4ۢk>m')T  ]^.᜗FRSG 0սp 7no`߾P*#̥  66X_ӧsssٍc۷Ba {Fï/Ɗs8[x8p옩~G(++Ÿa(+ i~̎C {Ch,_7alV jrb{Gl6cɒC?'(ٸzuMh3q8J.‚qffkaal8Ν_pvW:@5T]:c|}\$hoŠ;$ѧ`kW_Ju'N?૯7UUX, ׮m+Ʃ/{r2f[;wxlm J%cwվL>>Y\!筷ޣ_H=z, РZ99+P+)2֏oĦDQ#x/&(.n2<(FL%\I<6ItHmYYx^R^ޗ4vB)GcJ=)I5٦-{cu>DEQbD"JN~^)RRh  2D?}YDxO@`|B,+Feg#x.ǓB=Dš5%TIjuKrrJdFwFQǎ(::^xZh(::&ջ䰰 e&:̥Af҄X411si~s7V^fJMm}߬, XYeuA\ޛ<=YJcnl@jy~5dyOOCYWu4ײ%kۖPFK1T3 -PvvG4+85,-mIOCm9I$Kgc/#BB(+5}}MҴJ0<ӱ(V%\]َ؛) ˣ寰/RX ԩs;b yz>և/#j3i4)%0xMd, [ g||FRf^ۨgϗuIv0ILIIaYY*,Lnݺ,y$d܎}~ݴ}\FM<O "ج=xMDo"#_&}͛p:88]4Tg?cw< ( t-?nF``Xe\>'>?> rpXF"QtrCǻ5JR9Uˍ$f^hSnk^`>}L7ߧjhh;I%RQJ6mQ )#50aMx[ЬYu{> b>G1nn54N7|lݣ3!0β [!7:g~d2oܸԻ묬<у}#2Rh3f"3:%FQrb|_A/n„-$Pprr@NN#p` =<יRM%0xRdkN2{ٻ,3$R\KJG/`fVg~^!663)1%Sx8{+_?@/XgS6hTpРKhzFVird'}A~~H.F66$ŐR9ry,i4z%mH\]7bq2؄Tڭ ˙fN k \L,,Lud\߯^kޫ" Idڕ\ -_ά۶]L#Ѕҥ^7!k .ݻ֭O`c>@)nݚ 'b-d<ŝQx=DE}[Ã9f]lcvGDPpUHM[oW88>0s6=z6n\ox<.f(((+Co`ޓ<'@&󀍵5l' _ ,ہ%MoF3||vR:fIcںWR@ YJ11)(h-ՌHLR)m/O?22>Lm,ߔ Z 4Qg~8m3Cu#OJW n/Eә:|i7@37XE_QDV`[giR1nިWOa}SMk↚/ _'rv~Z-,(*6F&<=WBmgǃ6e׽r3FG3 &xnh GP䑝]O[PX;Z`6q'9:~C;${ؗo4j":uzGlZ-+ɪU^yMex/s'ۀ דTm]SLqqԲ~9""eqqg)zdtt.iۡMs_%<;BV<;;"SPV{3];M?jme4Wy ̡^!''YGL̂T?12Jj6"ķm;Yb(( Ǐ.\HADpt [TVŕ3[Q1AY$h@p~My&̼y#Ν3SNH?j|pa ZG11X&aam˧j?ɬ:>5ј2#XYIui]F7_~v}˗B,73Yoۻ.lm[imiOMdn3M[{Tl}93[ZŧøuKK젗_^ʛ:`MxKC"eN X/kMsu6h626>S.95z1++"?nnMކ4(x'yflzl٧Gk΁hi#6ONfKX~~~m/gh&6)z&Hgk'Ogv.o,a&[7?}>ҙ?g3^eŽc Eai@Ycś_ M&ju,̡A/MOj'çzeR3<(j4 O34 fiC4CYxj͗IENDB`move=1000;blend=1000;3OS6B1 iUQDjZZQDj֠?֢kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠?OZE@GjOZ֟G֢֠?TQUZj#'TjI H$ $I H$ $$!! HBBBBA$I$IA$I$I $ t,]m%!pf H5DUjDUDI$DDAAB!B!A*UQjJUI$DDUUTI!B$jjMT" U@""BUUU"*TMUjI&$UUDDDMUUUU@DFUUUI&""&jjDj5Q5Q$UU$h UUR@ $UDUj** vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6H7?1:?13 *g iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj OZ֟G֢/֠TQUZj#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB# .*Cm0P haQƫETU^+K,ފB<888^ټמcbQ@\BN8x.XД$!@,(d p0 2'!(P2BN6"4' MI 08 1 FPiټU(ڎ#,kOBmIS)R\$W35Is˚]-]w%J/z-z<1LޖR\~)hqC^Y殷Y4z{hgsL4hz  (v"*1M\ѕ%zJxѓ!e?,ʤb嚺tl&L2DZ ^mkZy"A'.]!Q[GRTr)k5#7Z%K{;ōX鸫>+?zz*\}a8tU14n*-"R#06 ?kQ$4Nip*CgA>ja`&1K2],^|5u]OZ֢Q\Zxi${^WKve(8ؑzyfcٽ \\Yo]Sdd,&ѱ^h%)BW?,ąeR5MLz$L2&JDQecᒩ HBd6TlӑM1D@4OU]oوճky|"]/4<1Ɲ]ƒ,)(hH"C0`  `@:$ K! $ :D۩Cm@hひQ(%(^A%3yo-V}* F]HY3 Hi.tdQWD ?Kо1F'@j/#E(JdZ[5=FjP`XH Aa!N!:dyf,ҟiy)#$$,,*& 0B'%"%:vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???#$=? 3Q@ N@3!?y+?y+?`O;??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surface|PNG  IHDRc IDATxgWu}UιR眦'QFBHF`aAc`66~A$[X%$$1Ҍ4鞞UUՕsiyw}B ۋgUU{sSh[VoAw:zHZWFG7TsB If;Zw:OIkJnn]K}l/"9{6w8~ ϯI~R)+VV$9C*eq*| vfyyo~_ߴ~۶~Mڱd2jM\.7oֆ$j0ŨKb1V;G.eqq͛ӡi_>1;+hTPWѩ XG8V+pGmhFqgAp] jWW@\/rwjum2n&L?ʩ92569H(w_5:,MǾ?R=o+ϯ{^fcjht sH2uxa +9 DصZ* li Tj@/kz뭬ӃrS_AjjUѣ_g|vRMJ*mۊ?gRDJ.p*(FGbe.z2Iػq#g&')J<K^{]w|{ȶm;J5Z:6 0koO곟}ޝB< ɤ+W(z$v}ŋ1Lf$Iy^hPDa0 \~?O8A](d +›Z>G9ryJ>'N/S.8{m ?y2b1wv3?,Rj&U~3  | D" Rv& NlTdsύ?jlR$ T=R.n )sW-bRkصKSOyQ(lb'_A15u5/vT7?Rs_ۖETr<>_bo~W/~[>W_N#/sCb?^e]RJ1P ԄԋH$\αtf2y @Pp%r++A?HttzFƳGRu'R)xMgg1j4D^nBȣ>dbubll3vi&oA&S}S(Dl:t/^#HpL00,/ATקRIƆ "Rgά#IH$^bǎ8@ MNә)$ d||+j ǎER+]]+(;mՄ^n\q䃈DRuΟQ(d.r8==#ow2*7C&S,z/p  j035gD&5>Tzǫ@XB^%qUX^^A УPD,v\)6HoE$"WTVBẃdb|>Nw'hO36@>#Xen bJDD kUnj@ ?Uj ڶ4ǎ]]b^F"Jh(J"[H 3tHzH$ ||H$ b .nsRI("v3?_G* 5$bW^AB/dllÁ׻@ B&" Q*g~~g)*U NgDN*\24aΜCF :٫nB!HfEZtj)ᰉX,ӹAԠZĹ},/Ǒɜhh /R.X8=rVVq1._DTnQ(y1j4uvlP3FQgfii hryv *:xzA@-Aa0P.6e'%1x6ng P* J &pXC: P.g-tJ"|FQd$˳dTYT*= \ΝYY)P,NG~+?ts}}͹ %TMܾ1č;<8@ OY9* RC+Db1]F(LlٲePi!BRR)K $|ŋe 3P64D"P'07,\F&0ch0,mx< 'XY]%˓'%1xZZZ(Hej6o>P(bn ᰟa +zoߏ۝#'r7yHdBVWa`0Y_C(L4 UVVKjt9 wm[DR$IKOjhxځTj!R)N6 2>ކdzFӆDR"B"Z-s^D,.klx5J%GzBHJ \ΑN{dd넃'4";eVV&SB^ fs:X(ښh4JF&"YQ@Pov8=|G9|X񵰼|B!\$ b4VZY]Nh,/_@"RI&]J:goEqח(`P.ר+gikQ("BE)bGGKy^4V7B(W H2baPX|HDR -PP-diVVfGY\[VHjt,Nay߲qxn8pZ͗cZZ:,.N14VB%bi"i(tx| ҎñRM&M!ia,M&"y.fgIWOӢVhkCղ+hh7@2B![̜ XAF24Nh4y fF>u~w|S|ۧ =| l&LH(tŢ-[cI$:[Z \ ?N2@P#I&㬭--30-["篰4˵bj7 Ko(<˳S[>L{{vK7 L@Ub4*H<ì/P,Fd j<e|>J6TS/i4*\4uLB!J%_:^,PI$H* * 3,c%&'&HrJ%oLۦMZ)Ͻh`xxǹƍ\@Awb4 ]\Px{ܤ??_}i49HG h=dzW)L5iI"fi"{lC4"(I$vlv ٷoLFTB$R,/Xp hR>[X$ -0{((\$_dlf'Ng1D">Mmma4n݈- n F4sSH$Y Q8(*ȟsǚ,rkcGtb@fɘLQj,4r<+HD"(T*R,W}Z ==](jw+_@g45tn,.3}d'}z/rFwv'Ir >B!ݾIub뻑( s4,Jm":;Gi6X2HI>_{7{i6H$R WfcB+ڵJŋ/"ؾ}rTA&!pk8~7}3Dq^|?9X,!)Mdr RrdFFn&JC*V\QNnx#o|.N*Bk29"vlRVJDsxϞ@ LY^ɒL6؀gE !JfϱJB! 7ptvvALL|D<`^E'i6˝ECk>BKKZCVXLh4;pl^oa׮[9uIVG8acK  8.<ςL\HLa:ML ⫯b0T#p/2r'TCGފJDlChE*P,ΐϯs#rR)FYE Ƴ۷Si4  FE"7ވVZs6#g0Ш9VkRdM !e׮[h6yϲkQR1ccvf#.xKܙсAoH5nNsd2)JCC])w\~?yN:'Nڈl%KJYHR?$b}d'&r8E"D \x2)߶  e$Ib1.{t:ud2FA rdދtnCs ɤR)KCiT^>ؽO?ȑɤ dGPx/rZIl"^E*5VI$VHtԁ0]w IDATK@9J$B(g`>f'^Qyd6tu.z<|kZMu36n|jR1,#"HΝ`HX:9 =K2tr v:tf8q"E.D&ɫv޽ ߏD S,,'Jh~UJl6?hPh$|>䀻^G%2B2~Ӟmm㽽k5u LN>ˆ  $ttHس}&[H%H&d2ttNdjH/a$kP9H>?DbًFRIR,DN2>~݆NN\EI*A.8fYw*ş>}~#+Nr,Ä:Fc&]&Y*=()l6er]~~bFe624Fc bd2!>:'_ƛn;z˴ HXtyk? ]yO!K݈ed7a'ϳZ3WҶcMܴ7:a~GZE")߁FcAT|ՊPE*lqHdohvumR)29yj5KVVD d2 Hl]DT*2qR)ФEG @ 6hP8?*|a(d2i^:ZUt-LN^obqWWS.W( Y,OĆ (-G1$4qWV8@[goP(ME.WGh44 ϿPWJZ?bp&mF bT*ك^o%NO\_{*F(]^c2puo>]w?fQF+\c\?lHsPdHe2C!_cbn|Lfl6J,!R+L4ZM^ߍ"R07"#[`Q($nRE2Ffc45V jB.'&ކH$Ph0;ۃlVY:СavOG &\Fe21kFo0H"$Q(NHb,[:Eo, a ǹ2_ǥKyvQƆ TJh,dr5z)9Cz۷nN@!,ioi<~3<D.D" Ld2Jeby99׾B,0˫L̅Y_a. "Qb1FJTQ17RRul֑J̈́BSN3S|736ދ\]G0!PD"켙D"K(BxAJ0lN@U.CZ,4 :{κxA7"I2B겐ND\0*HA&ٳ(JZ;;щ<#om=c<v$)/\@,FVlP.  E7aL21ZDc?35LGA $fx<WI$.R(v;zDblv?9HPA^fpPDݻ[!a0Hb6kyߍ^ eis)?C.W0:i>O&eyـTGH<.G"qph zmm*rCIQ?~$Fq~,Z9BB(R@X%N>I\dmcGFK\z5* ;^?e>(Gh᥹ ۅ`"V+ vњڱ TjZ,&n*fR DJr*v>w3}3IDH! ,SP(:t:;dL 1<4-X,YP* N!(RHvj E'[lG"q"FOLNtތR# "RbL`y9LEѨC*5P jI$ sxnxB~6r)F'PݻQ,*-en<9r2AadiKZ&Hs⦅h`߁T*fb"B˯q-ws AvoS h$tLL`002:7/&*" oD*H4d}zr9H(_HT*j  rB\nxU'(rkrTE$5Jl6谍+3xD"10zu##d2!\Ӝ>4M(L--53q8XoԘf3rJoznb bHozV-}==m6ž%tr]l2ld2ѝ=Hg8$rP@(x2 D "~?*'-u D/17@^_e}ݍ®]A \.A2 u9›'oA2ʕs(BD(#D0\DpFjH:-EB"QWP0 W;XY R. EJY (JRѨ@ HS(4\b1@o"5:;d2^D"DkrIb1?lV-тj%˘?G.#LGQ[[j4MVd:hqH4@Ы#ZZ¨#HR]}}(pya'NOH$B"MJPKPfQh4"8Gϣq:Qj4 jN?OZW(-J4^k—򗿈sۍHtt:I*窫vnMddh4jrXGOzYXs"PI4Z X_'#a H;1 \"cjyZ-ǶmcX,!L^r9?\Lf\ΏT*\NsTjXPDw b^G"qJLQAhH6 ϋH&KoTR[v1֭ܕFc'%J:8PkhCم4TctlDT4uR<~OZ%L_]jRRD:D"!KKvJZî`w: ,/s~u$/kHy<JFѠ{7}>?7gݫG:21?ݝԋY~?x~a6z$¥7M-̲2 ,//#ɬ .RGl'!)r R.JIrxe\^/}==llog޽TwFV093CX HJ%lv;rGH&Rhe2V+"ܰ:j57} *r*%\JTw݁mł@$"b6pOip-.lpR+J*`i,B8ht1׿JPۍL&c߾AA`fq " Lq JDFAt:)GI#t@ FGFj#Zk}MB!K(b˞H19zM ;͙3S\l6yvzVJ,PKGjf{vf&haD&A r"i( ^{ ׋lf4`cdsGpF)r,nnP*ɾK>B [_~ <Z-:}<`o/=TJ%Ãj~TמGTlcD"kT9 ,.B z0́pefiNN8wJJ*U/ PӇGń } mRln v4 l__vSYZBYÈe2:l# E".RyPed2I*&ܽw\us讪F7L@)EJD˖%yTEP֐2fB!@R(Ÿc#E(g%d9bbhg8L` n$!O!{{T*pE("WX8?2y_ssy@AS#Zt: Tl18x I&l\2Y&pWY^>Z=BG%5PdEbi%ACZCQTNq7ޅpi4d~xJ?HR͍٬P4iOhP67q:k5&Ea^*z=Β4r8npjȢHZz*A`s B  H,-(0LdAҥbɑi\n7}ƨ/,O)˸].e@9`Ͼ! O`1Izz؊vI}@E,z5_ܩ|u./lno`Om~?X Ip8q <.Aw/^>Q}}ҲOJWp JzZ̰m##FV\wIy.~?tc8\$D"J tP*EXjma]؜}욘^*>) `6%n3rХ"SUv2fH8w/\`SdX鳯 wդ\²B^g#%^,rG#@ᇉì,,Ci4t:ZtH*G76إӡ@R~R`|^BGCeJ(VJ%NVˑ5dABLL!͐ɬQdϒL"aVW棃/_fJ#IR)<&WE,NIBH=Jj|qx$qP@n#, jYZZ$ VE~f$') (V*LO>OQ/Inǥ(4 lSL].4G`NfۍTga*v;V IeЏ-q{w7/9(6kSNq…5@FSe 7Zj5jP3P]2Inl FYK$x-ٗ^b%q JEI XT*(k56yQdL Qɹ9~O2E٤Vc3g~4+DtHر71l x߂^oP((cT*t:H^ϱsIJ=F6+WHRSPt:MXd%`3k`栗cߧNsK6 V??Νtuu3&IqfB!EZ++$Qor~ m!" |Y,Ln1DPyM|[liݦn#V [,F!]*QT۬7Q[L&j^-Q*eh6AA%_*k4jh,tvQe9 s)nV.ZM7:tan5r1УѬש2$ `RY`Sv7 >U"T,oorؾ}BhT!ޤXjJhz_XL0<ޝXn.}[ILYwy7V .A`  Ҷymk t#e2M8U{ o-6fgdZ T*QϣfgO@sc'" ?1j{є(NqhĥѰ ^\~? ^_'/IeJj5;v _X霦ޜǛ^y660T*% 4vP((f#B33g Q#qz ?LO"Xcn ϠGT⥧*1I"+IЫ(jL| uusq^QR TD{wo7#Z,|RM0[[[z5/chNB2P1 h$ EQ "k5FFlF!帣RaSؔeXi0j.~OS~*x<j =ͱ<7ŗYޕZ卡Qz{)#|D$$Qe$dZ^z|&CZe.&?1=&K|d|;^xKl r9--aɅBT$ ^ORgtWxvN`r|'GlWHѠhTa"XzjVl8LBr66V0V p8X/|6Сfmdz~{+cN~^?~c_9ƳtU|6@ Ԟ{ՊbOo/|CZ>JQ+iK>c}}8-.ݻ1oۆX,oi4hK<<=>C~?PX[YFXPׯA9ϓ"#ܷ};s-Yf^ǨSi4sxtr]7|h0h06;K;vx\&+qj_}ۑ#sGj09|ŤףUyui E 1@G'  mm萧D2 t9Q`5U_V{|&kOl~Q\Y_'LmӪV ēI&|R n7X n?>0>(%.߿=a EmۍwO^&91]fރD)@޽SlfQ_fQ*1nnIۜTXk؁l$o=~3rϷVǭ`n$ž>z>ssdj5[-YtbjiIZej5\:)I"h3rfE{0Q,!մ.׋l2RV9sQb/DfYx ۝Nvh$Q6:"x_$od[zu?:rUX`NlFijTJ% ==( k4\h.GVi<E…K:3˭b.@u-ɗ(4%L:M0$ϳkrt~\N(Pp:XLz os= f׬JARQ|Ut@\:JM_"㺘x݋ĦQ(ld8Ș\:ͰFVÖN3NfC[.KZs˽F&CTbrr}^RϗP*Q"({El2syr ժS1t9q͑3KEez{9V,䛌FzfFLF`#($X߉+ns߶?T,?N&p륢׳P Zd==S]](qp%D"V"tGE}4Ν<\`h*j:s#p]窯Zڕ ~L" R)z=vdX޽lf(=06j5FE4:F$HglFBMz1%/d߾;M('QrԹxnvdFRlbQj4Ј":ERq!e5#]s9֑U^VW鹕KsLf i"50*f3dB0ڶÇ24d#kReXL|ÿJo .Vl3O2Tp/xenpz0r{<*tJ }Yn:I?VG,$c4ٵk\Nh4S4u\`:NdC|ud TV H'Ce 3L ) $H{p^dSsaaNĀ,$dpZ˵A،߳B6 B8]e``e-##7m!߇^oGQ4h TGC tXI1>G(9Fr*n<xx>X7ht6nrtw.3sP Xp~qC?Żk'7(LT*ױ a;4[-'&XIYXNR)ٱcF.!draM]Z?{kܺ?n$!,ϳ2LZe^gZ_]IU*ertZMRBFusL! : Ikw`ttz^&nI D{dzzRqbngT)?_^PDZvEvjp8p DQ/_d4bel*ŗ}PEfA6i%U:Fqa^L\rDHQ,:bQ E-1Pi %}xwËg/j5ht(GLA6nT$A>^oEՊZVV.r{5ˮDZ9IMJ\YYf6s}a2ikk 'UVj; ؁ccctrFCґtJV+4ZͣSuEK/-+'9eu˥zeVfcM"cf$JXtPs#TFD1(xÚXƔu:芭=tA{rѨ߹~sx=nB:$`02K8K' (ґNs*DIY@٤AiYk&AO?L&exxdžFB_tѨq<6`yq8FpZ1<P1! DMeԊE⯿NR!V8obDA1)4dQ:2p]@g۶G8zMMLpBQF#W^hIx>qr18᜚b\oT0@BvpBc6n6TL&.J3o;yV+R Jňk>CԔJ922[[<\3OIgY/ 2?^/rhNؿFnzV3=M^vS)Yzej5V``qѣT* vIfC7;KprhV(PI!6f$aj5zy]k\w $Q2a0ht)L2YRlV$[f寱q7=t_G3E"1ؘݻw9n?Ƕ@eVVVp\Dfg)J J *T.SQH:GGiR,TY,>(V+i.^d|09kVهr9>{=lc4f]GMT_v~*~Db Fl`N?o|G;(68xp&?ľnUܶ CHv3Ź9 ۨ5`2I+nSE~j*y"&MQ$[b>):^:(0x5,ciB~v(uA@nS%k#S.ZqN7^*@w}NzmxlnnR)rݎ<ȕyH jOOd`,ŋ (D.fcaL==xa4F7IBxo* <~:v:s$ h I8;c1~\wߏj^%r0Ff3%@qꙧ<q2^:` ъDªn6 ;Gltnۆ`[|p"AV#˱He63' &=FGy6+F 5i) C e~El"9:H #iu/0it ^ދ^l;DnXߨo8._Ơ mq,E|3.W$ł$ʒĩdK<Y^^{E, HÅ1twka/ɷZu ynrȂbĦroOH6tV!ˀU$&oG yl;,r) x^{+V0H\&E.% e 'IDAThJ >-l]z!zlr1|^/Fgjqݷ2o?%MLm`hp[Qjڹchj yd@ 0v m09(f: ăt ZF4nyB&(ReJ 83ӬQ.$l^!)!Ht`6l0o7b!F} nA`'>vayplUνT~JIzV6K˅>`{[ ,/tUdYƤt u(9:Er@&>o7Rx`(K$nT9n@Qj48vK//)`4Q jJ#gd*r@*FgdT*1k}}\ceeM >d[[l~NWĄqVSenl'۶E,!񾖸a1t&M z_8.vr+*j5*Ypw mwK4M.:E4GQdA}wW?VNR.҅mIBlAX_gnQ' QEQXWFs9&og2شZ* I)ncbχjr,馛T&fsO h\8VK sO@~/0!ncZwr",.(xưs~~u熇ij ;&P"&*:jZe1/RT+ !YfRH:Rh$);o nyV4j5z%F^OߏjERA"F'VY~Yj^_ _[A}?uA.^8M:hLAIBH6pL,&˗[,ZZ hX zt|ppx_67iTZ-n7>kJ: ]@e6${6Y+Ij(j5޷c_F9ׇnc61k48U*(}h u:rP0>T*(fbv<;vaqlpzQ,B ֣Qo) ;;F"mlVAXR4m DUmE$e:"@X09y*\;o1m2-;v牖J`29s{͆u-> A.<*lQ2rh\n/BT2( T i-F3↑/3ùpᐔHqm^mc 'yȃ%KS,dH oX$r)#Ź2}ﮮWqr8fH2/7s _ynj ]jn{qZ%Rm) IMcq8伦b&}봙q}'{U?|9 ȅ?r*xufB!o$0S$}F# Q)o c825K{6SlOX\Z_*a,̿=)Jc޿u OI%IlqWU6+GGH0,ĤdJ&T nlȞ2x2ß`L݇)mV*NFJvDrJnpPﶨ  4k4b.s׮~ @~ G;;2ׯ!\e&e?3 qЀ?gmghüi\4†"ŋq"7;anj Q"tK |&xO/.}En޼A]nDilewCL|'On"D8+ ܻ!7xNZkgp9$$č *~loHQdc0|NSm g\r n_^}y<lDE4ƍ5F 7{Wcvk5j5J) |-{=BV#}RO&D(ZEvE_2Txds ׿={qdN#o@4.iH&3HIbٝ;A:ju0 %3R"S0NJ*][c1fgoru449W(+ 4 u.(&ӡ^(D++(A:!L1('υ*e)ȥR4mtXPb1./,eQ*$RtLZ8N`mH]L:&p磏0d!ҋ/Bi--ur5?Ï{fdd1 MnV~pF"*qY&p2S,zoo!sw ʉ'HtPC~eu;nLqK\w*1~QZe٠߬D#?]v;~?ZFV= qt3"}f~wwi/,D(ED] \0k /(#I JLOgFgfXH  N**'*r~.=Hp7qd۔;KK F#6MAKۥ7yd,vTY66YmEJCI"??O0h4c03?_+ W^g̛orldE!nRpH2p]8Ϝa>@Ѩ!Iz=H`2[^uvŅ^_? g0YF"^: q]F dLMql&$Ի] 4~.,:&ir㩧X^XxLߧ93PO2?k#۸h @T&g_xxLR(f2TTV0L.D}^y !J HE>F<0-2ϧIT" ?;*|P0w.Nͱ 2r#98:qc.F\,<\ۦT6gn6E^ߏ ]\A)ǬV9g٤9U$3 uZu:"IĢTwvD sT':;Fu:F`舤r(u.&AVK6g>CS y啯̹,20xLDqq"P,ҨףdQYEʮKu0^wr,̭[H8!SVzt]fK)%}>fIu<F6˫IQF"WR=:<#6zE>fo8$(^]X`4,u1Mó8:t3Y@ӘVU Y*;;̖J_x?).]gYlG#fQ 8( ؞F(TM%{2o6b8#.#vQG:aCp*ij麼23-$ALEub0|V*% /GYpMle%[-۷*:8`*D~):AF2Qebw]&b1򲌏 q=eIO|ײ( ~G(0ڈd`&3iVK+t 8%LlREK80ER\:M$Fo &tO"Gu9t].Vf#RSPΆl5}>QGl8L,r]k=]'[,bFOٴ \d9,Gi4*VM8tD`HMo}iU_?_\a7<5Zw~ăG}T]ǛGUUE0+,B^kw 0<7y&k6Ye#D/ 篾tl:MpHRK(WsivLfRD]C<.&2ǘxLb?dd9 $ӼDPco6#O&1//_`sσSy|i$(I"yM$8 a%Π $D1Ed2- Q6")O,9@MǡäYϤPIE?pQ33Dj}4@UrrgsшjJޫi<9?ϩ8M:1<2B;gPH(6<@T4ʅkG$I\fĆMu! 17uxȞig!!hHr4 -,4GXAA 04/; wޭ[',[}>||>$;ssT}d%S c*I3,tqF#M2ʙgrwE"6̊"ҳQ mpttK=y+& =M!=w^-j24b eQ3M:eeǶm4C'G3&$&KWAUweQE\p><\öm\hi΄Sy~Xds8D4@AzG53߶'%CU<&1=}]$QH$H.@ _ppsG5@vܽy8iԈJ"L(ľ >*2hyqh0wv Rf9q]|s<{juIE,ˤRiP(\FĶ-Did9~?nbdXN5fZS`t,qmug/ld\hY 8O"Aާ&5 ^"0ܠG$c6Ki4U߼ F:FPM&IR,xK!F,&- 11M CU MݛXC3|~D59"Iq<K-sNE<<>FUU>zF|*4UIXd㈶M\f`Ydt288"án۴/\FH>W&Bd G:\PH² 2'2Q?5Ɵ5fy,fӡi$]eEJ;伮ӯVby@zjMXDE2 ?m#ZGض/k~48IM9ta9:^YQhx( InMNJ˥! tT*ĢQ `8T,\CQڨjACIB5M [?~U>e%8=|DPffrDg-/ع}ie\0uS)b7Tf_C|>ʏ>"Jͳ[(SUFuhVs]}^3{'"m8""l)/=wA @0 Ox ~"mz$_ @u1Z<0{2xb3|/$d)kIENDB`move=1000;blend=1000;3OS6B1 iUQDjZZQDj֠?֢kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠?OZE@GjOZ֟G֢֠?TQUZj#'TjI H$ $I H$ $$!! HBBBBA$I$IA$I$I $ t,]m%!pf H5DUjDUDI$DDAAB!B!A*UQjJUI$DDUUTI!B$jjMT" U@""BUUU"*TMUjI&$UUDDDMUUUU@DFUUUI&""&jjDj5Q5Q$UU$h UUR@ $UDUj** vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6h?1:?1* UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU*F8R'$!              3*7+2 -#DK6,XDr͚菙1fz#'kαv(ѳ3*(-TgG 1fh"Bh9ŃcsRbc!iX bJ*uns,u[lif$h-VID.*TSPi)ˬfmi)K,u2S#Y gn^) rs{--uMlm4iv{Fӧ5- Wn>xX||s ͮ^7n6nyÜ9\]Lix謫]x]8Wqg|Íxuۍ^_t8\7閙iTS:wyAᑉhϢҁ"Aiؘ9(L#^BCd~kު,ymێynpÞyC`mq}t}L*ðfB0I3HAwk#bùL$ qRue~y^[a t`붺xki\ku[G.P^daS t>& iHc;p b&{pG{AЀr.ʋt(س09/2w;DѤSS0D"+-lm<}ﮭ1L,rMu׍0Î9׍c `L!>"1\(̴Qaxv /z*P|=-=|s{n[I^ef+ʤ…q@Ap PӔԤFx۸yؐ.r(H HF$\iQ$F`r"燉NJ*LX\)׷y(۷Rsb*S 5IU >vltpF$"\1v: U9\ȠiTyѣԼ䧇џD ʥggϙ9FhFZdS5Ru.^^uHNT3Nf7ܬXyp+,yJsu$-4)S N*kl}4iګ-:lӷ,o]-(t)arz|쬱8PLiN"4S#JjmHai4Ͻ;Y^r1DإB>n#̽И:|H$7 n$ 7@Xݿ 0AD bI@ "ӷn;TCjhQM5tJVrkuVQUYE4TW[S]P'3)<۬=4u - DhLM/`I,My 0x0 mrθmql9mr,q\vMM/M4IQ4ܒO;b+5(rXD@r}Qbd5(Fr1#z,hX%PTF/_84#$4;*/Tf AH),ƅEgFhNbn `v @بԼؘp`R|мԘA `p 4f"B0Z L "`j ;U[]]]4:wUQe͛6@h?Yke<TrRCJ)4*(!/5..&HƝCN I ̌J 7@#,ؤBRjVbzTTcvpv`{G9]9pfZF9KC{{Xhj^ѻ5NV3@p fPA TBAX(4( H!goN*N*oNɎ:ckTΜ===*':elW%IVdeBVZalɫVMS&Lɪf S&afa)*upۍrmmt;w/lss5㖍=rEƧGDCDCe RA+h2/578!-FRXr'-)ra89P` @GXu'm UWM6禮3nlL4^:#&tvH)>!bLrʻ4c 0Ü8ˍ6j&L>y^djUIVZfL2Z ;Z/ %%djbVLjdɘ0WxF^+8Íqs;M1{npWqιn2fZd իVZjլdkTѵؔk"P0dL2dՓ&KY0`<8}3>yvuoIum&vi[\珙XXνrY6H&728x @(׎x\8l+㝴(݉nw ,[McRڙ'NHr+رP{hF|^YnG۬\`u u˖ov9i]}BgMԪf*iORfJU,Wt"GJb**mvی&j6Y2dɫ%IBUVdɫ&&`xF_:Ʈ8Ư6lx MUsWD!/Imu@_l #`0K"wCյd95-L\Ba5G&&#A`w+.R BVĦ ;uKҤ=fxz|fZ\ccGPd0B!z5-.6Dy{E24:TvVvX+tGNݸn72:^0t""@( 3iID-@Ѥ&Eݚ3g ܬJt\RPB)R(HCw(KS q6E50H`}EGaqm΍Ij꡵e߾uϷf+j$'2׎w-x_p"mS\PE lJ('BȲ&L.R%xZijfLJa8dɚkƺxCIBͤK!iM<W ÁXtF)C{g{(n)!KR\Ar-u\]WyMV ZjՒI2ZɂfS+Ý-%ZjաX``Y*VZdի&L#2p]a0< <#Rd ok0-{%HS׌0U`>pV`yiVMS5j28a9mC>B`]`| 6m-7~8۝`2<dq-@Jlygmum}Ei}ɦ\'y;l `` 8^0}3'<,qsxko]if߾YUWQ5uQE3BVMEeuюiu]Ymb֛c ի`t-7hq8= \u.9 MYes8_]mf,aK@) sr,Lsިbgw \BX khmeu*AE4QEtMvUQAE%Tun6|Ǎmux^yWMJP Da0q<ᨂ6~x< 8pyvۈ_<Ⴕ|0_)F[eNz.6nvƏ$szk}Ҵ|充ozi8u練4a`3VI2Z&KY5dkTZ\udՒfdɫUS+3VUÅxsmƼie릚g~8{ZiyUqs+cꠑڊkifYqƙ<kSjfkbb;3PntجxlTlD9zR} 'efL#<@vz{1/EyJ, *l( `(  {+;/w@ % B 9i{UVQFvnߝx;, @B o="is+4tuα:v뗹RrMИK, ƄhPRv) b5fH,ӸmMQ]߽4F& v$h8raMh듷Lqnr^5{eQキioEqҚn鞚cWUг3.<׍vۍ,u<^6Ü0<#WǍM8s;ks8+mﶸV';-\t>*8@`HRbbL`dHAѰZ:-)8DRbln%=% ٬oMe}ma<kZcX鞘VeYuAc8 BanM$!}ʘE0n(CX(x-ߞe}i\ۻmu5jn1v]om'p踸70>nR0`xao;L"$gN u 6c/T'X1 @n&D` @9Nax y̼`Vp`Ą{{ދ1ԌnDFBDZ5H®"BܠnHF7$ec8N+ b{^!"$wDQh\9F"̌lb61!C, "ѱq0V'Ľ z%CQXP_9{{z {{{*{w{Z/" RAФа $==@҃JT P <fŅƆeą$BIİtnbbZFP'1F`yhr%!N͊t*b}ۨ>^jHfzxTF>ۧnAIcS ܾ Ap dBx$!Keߞy龙祀,;;}/.^ 82 Fe1piK]>J ^MJH(P*N|`Hd.rݤQMUwRr^ۧ 83βt2I$2:c@0tn K Ăe 'P y$|P4,:(i:i$-$MSTSR*j뮫Х,67+<NAWoYsD{m(Əfw<{o}/Ϋ(]v.95xaxss8a뮹gd:ewٷn݊u piױPFtpļb9#yAT. 6 1iފ+ hrPjvbhZX H`@ !BV`t|' "&`2157 K  N LJJLH`A p 7f `,-L@IWEUڋm=!(j _:펙i8aa붺\cjaG;saƮ<J!/*+(R:/y睻vpzo1Dzyѐ7  0F%N{9{ވ(s/{qHNP) G"Є|hLPn(ڎ#,kOBmIS)R\$W35Is˚]-]w%J/z-z<1LޖR\~)hqC^Y殷Y4z{hgsL4hz  (v"*1M\ѕ%zJxѓ!e?,ʤb嚺tl&L2DZ ^mkZy"A'.]!Q[GRTr)k5#7Z%K{;ōX鸫>+?zz*\}a8tU14n*-"R#06 ?kQ$4Nip*CgA>ja`&1K2],^|5u]OZ֢Q\Zxi${^WKve(8ؑzyfcٽ \\Yo]Sdd,&ѱ^h%)BW?,ąeR5MLz$L2&JDQecᒩ HBd6TlӑM1D@4OU]oوճky|"]/4<1Ɲ]ƒ,)(hH"C0`  `@:$ K! $ :D۩Cm@hひQ(%(^A%3yo-V}* F]HY3 Hi.tdQWD ?Kо1F'@j/#E(JdZ[5=FjP`XH Aa!N!:dyf,ҟiy)#$$,,*& 0B'%"%:vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???!!$=?R@$&D@µ@???`S??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xConsurfZPNG  IHDRc IDATxywyy#ʺV%Ժ$ XcxƳވ cώ׎]؃c01q -Bt껫<|{ȤcXK l$c?]oF>o>yRrYY"7trソwㅹg#sLN0h(<?@@5$ cc[1$(qo^G'!?6Moz'7cyiHȲb1k @EAt y 7 8$D~oW~=;mW0*Z@D,fm4AGUBXVBq(Aд~#II _@|CdYB& A" Bu8 ,OlbYQyqqb czRo|T*VVڈL:$hZ^B׋LMcttI3g>Ig xL @D8NA}Ӭ#I*Q/O'ks:Y$)~Iu\pSE?~]<<9qAF.]JIry~ah#: -$I>>GU3J%fE}T&}o"I1{$jg %@eK~E1EE4,v0NDiDqu$Idvvx {y88 4Im-\EX*Qyesse\Cll,8RmEUDQ_zUJyOՓ$ƲZo9q>QGUE(~h69z 12E),>$ bp m/SGUıC$I}<##3hI o%ez,! ]GGDB2ٺtAUMDQ^O$@㴑e,K b"m8;_(R.oTj(EBlv3>:4 .8m$i+kaYMeN'<_FY& a$ɜ<#2iUO/kBg0)"Ic˖|%OVrYVq,Kp]Riz}EQ \s[>Eυ gr'רVs؃qHF /l>(ƔshZ忠]AU4! JI$IBejR}?}̵HOvM+$1Irϳnjn{y>t?#&[Nq bqju<tXY9O$/?GQ`f&&n0Q2^K&E66βy$ Q12iq?ϕ <A$M}%,$IA+y# e#I"<E4h4~Eј"8ŋ_R' NF:Gqt::jN5܋(J<' CƲ4Mö4)u,+bηp ÌPEUMVWc|<ϟU퇑wm´Q$vuFd$e?#}(/Fre~~/ܗQUmX ٵ^ΟbLXcm'BDQ rly5ihznSF=9R*RaRX su xSy sdy2OZniNS, 2^nL06i"a$1$"E HD&8*yiblVjݬ}i((,Q#I2QB+ijL]r_ I:(ckyJ @M],n" !Iǟmo{ٕ42reE$]_Ra)("V~Ͽe~7yts<.g -Pш>&' 4!y^cv_'4/²Tz( ( x?L]dyT#Gz"W<ZRىm#ХVxѣVEq.^l$1Ypp N~?BBaRi ^N}ZmM :i}Ơi:YQz[k5rVOSF[v?ː0;JTu>#}u<_ut},)28GQT$IVVlö$Iݻog}}Zm/N?,6{߁ß;޵,`n612r-++*l I+i{h-CbqE1;ڗWR."2++P*SS81AD%|,ky($O$M#v˗ey2qcRIR>y'Y(9a yBA CBPCU_^ɱck<Ƕ0AFćwV! IۨC*I_u{gw߶iu,8α1<'U(C7Wr#?[Jq Q"b #Ytll4Ri7I,%n=H8Ѵ#P;Flr'f2>~-##{,.>qQQk ,/=l²,֖9s$K H x^@ lVVNQ.OQ.Wq FFfѴ"ٹ.FF&T)&0\onop/*|(ˈ0˘$jGF,(e|zxh1""fYauDimssLU*t,Q ^s'8qe/XO|[<wP_On`YiJhk(1qz:Iҧ\uDQT*a#дSS/E"L1t/$IatBjP,ҥϒe1d>$m5&lk_a̓uz=BACU$FNy ]h@9x^j8N1ҥosO26bqQ4ٲ@W#4KՐ_Ϸ%2,c\0zYXI~iu=e誊Ȓ(A@ۥT 2Ia*,>=マEx|yt[cc$J=,,(A'+RN$>?(J,/ghI>~4m/!>ss7 3 4=:P:jnCgxIY'a|5pa;a}O]ј4K#@F X>aN%xM*6q׼ _`3nnb |}~ˏ,$v d`q|5O ,,*IH@\8~P!(ss|^<P(@Qj|Ə~YGjeQغ6"I:Hƞ=7RmEDEr7Q QȲN{ı&$aاzb(0:uli秙l022FP4 >zm|e^~p A>q.;GeßRbQD ȡCH`ׇf"[8VewVAzM >q' 0dq& `TO>=Y敕mjבI2Xy ]t:ؾ}0QUc}oRiP,VQ88vkăH9!lqGغjs>ȎoPFvpKHFBaկcǫsS,0|9[ӧ$ILrZ{آ"˩S'8 ]vrHxwZ\z5Ȋ0$IOtB&eT :O<IB6\_@w}4( 8ʐ$^\1I2V}A|ӛh{?>ѴqDQh!eebqIҨVK 㱱$IhZYVi2ac~~{[².S,@'Ma;"#MCJymqȲoI-8$= i o?i$I"c66G:8&ФV0*,/? bFg.<8N?N6JNXFQT '"Z5./5YiNZM]s ז˔s\f~.N.,)8f` c2`T4w 8P,2Q*^ Scc}Xf`r`& D0 nj4x9Dq0{s\ ,Br°I$is%婧>Ȳ2\%4ͤZ-{\7iނa$0AlA}FGE! #C #),26a~&CqWEA8ӣټ dz+ yp]Vض=67Wٽ:nnSS|QlEpfyyi>eI12˗&gf(Rr {C8Y(fs4KK`2EI.ITÐIZPU*۷OOml6:s('˞ceYǨVA rBv  UuU4&+Aپ$ɤiIǷi2mxwc2dYȑ7P.Ka4):a,S()i5J%kc%IB0"|ǡC媫v[&&BˈD8z+ıiдzuXrbm4Cc%+KK_zk5f^ӫċc)bmnKDN EjY'Xt^ P$d"TUEmHٳF8lJIqJ} ?9I #,A Ias3 \͎X[;7G~Joӱ}߷MMrybQUFcGs @X0LΜ81QN0IJ,b [ `" ]|ߢ^O[TFi4T**jCnС9pf`ǎE!ŢA/68~왙V.S-ce,D>:1gmYxr}Z SQ%)Em,yN3خ% M9ȒDA,}`cXυM~Ó}-7ju+QAUG>Q2q(A0Jд<( ʧ4+ȲBƜ??G,;Hıϖ-q=$ 5Dq$*ITɓ}°Ch^Gz(@Q!-ui2AȲ?fgw&#Jngq @/B5o"sDzCCIw9p`DQ*^io?jgy% x`jF.i?{$pmfpÐVR3M* ҐH(-[A]);0m۸R x{0,TU c*E.y>'S Cbܼ@Ek''wJ*(;ປé(r$={nZFTKM;1m峤iY80ԉm\}}&K5DQFF^3ְ>byXh67P*~ナFcM,ˑIJ,~[ԊE~~V~L(C(Ȓ4 SUIӔ9sr`d'mp,˖LJxqC.@ P'~⍔J$IGO(jeضEX2 ]P2iE]VW#DQX4YY:T!BKMDe0:: F}u0tUt"|2^0`.L$0::O4(C>$ ֮wosć C߷HVkA׵λe}ED|[ A`WNg }폩TLuAjЛi6 f ,<Ι hN􃀶J&~.ar<ǜ"2vrIY,˞ 0DEjFO+˗(-K^rkιs<Ȳ8HY}oSza'II4vS(SW<(*%nmpզ1 ^.)0dzŇQ}IۗLOϱm[)>rq:5Th6;tuAE!86NӧﺝvMs-?0;J pnpdf8IhG{Vwu?Oe,1("Inw?h+u4MA0 ycKh,J: nsWesdE)"yE}""$BZêH2"beދ q 7k$I6̸Ȳ x^ IR<{XG!4@{/,Kvׁ i6QUG4s89哤i/gsҕil.qwaU7ׅ(pMӆ:hIlY[` @6nSLUE8fR!H.Ӹ)}[_z!gCkՋ"ʪ:hƃ[1_җ5xTF*Ґ sLLdPQ.Qy.q젪233Ѵ2++q&Ia%@&Ye9Ȱ"$C:<' jϳh;H$  <EEDn5btljy1;;FD⩧>m7)IsȲ0 7ڜ9s4)FYYy ߷<nj-:KF\sx[nW|.ӯD/TC"q}󰃀f?Ip~n<;E|˽rb/-a$j.m˗E?Ip+Xu]xK8<;ˬ0M޴gl'ES*Uɲlh #BZH;H$ %H>beXFqAUP2 T/%V[3vo޽{ٽ{z-_Q /_8N($ Mbqf!yu"xA昚*|ӏE8`ZE4>[HAxz-,MayKKw7Zy}A4=$I0ty}̌Tzht|cxtl[ogu+h>QBE=m9;Ҕ0z믿z'ǵmr@ B!  nRU^?55OgFGh7IxXHS\$9S, 2b,A@%VW/w Qͥ+| vry,Ko}!~;$˄Qeۘ>MP=8&2ږ̔JLHSh* ~'Pla`*<'edMCs.s*"K++dYF? ܶ ol zUe41M>u08MO<Ã'wc $I5hضN`m$q:z"v{W>WA@Pv]p|䓟q]ʥ$ B<|ٛ^*:Ǐ Z\*u:lzA:yNyikIhJeȂ@lٳȢH| ncwy8&+ɷmC2>+U(4l`j̅ - atVÿ@o!.e1Ye>iǝw"I6*:FuqXV%*\%B<##Wy}°O@Q $I((F<`<RBa|s_6usصŌټ@ll8X֠\z q[qMNyiCrh>#,NnwS">qm8QZX˃ߧEUeo:Ɛ>m% 8xQSxQDE6KQcv$ϰgC v&Kxm$I, 8wNgNN6d28?βJe?nLsŇpudY'S|fǎ۶v!9%MˌXY-칃z}+QTEs01Q\.R(sks·HS sLMMeوHEDQDGH( ;IӔff @v,mgVb2is9 !¡-[3 ^3=w8ϱmha8&i^ٝ{E>벌EA@,8I<+cYJ*i ,)%$h&(ꌎؽH\މ,o0!eh,q(QN$eVFJ8N6Y\(f<74170 ,Cgi6_|-[FYZZ0t$O& %X FFƲtuDQN/GD"A1 -HU\!Q2++T͖׷iQ&-[cQ<9yb@!&73wwzڍѣ W[-lcNy,D"WaD"Žl P*h_\[Cq|H[d2M<.ɤDVJ,Gz ifMpZmpGVP'mND$]mH4dz$%ϧ%R,k5|*DůԉǓLO(8iymgVN;pb: CNP"2*1w.&,D]G5 ZB!OdMӐ!i'Ngl!NH$XaP)(oD6X_+Wp]qضw/7]LU|<*b/-is#NS޴ l,,"i"9UAOWWxI2%ORD"n>O$c8\*kL,K0>8g׮C I"xx5f09UQds'Tx:ضe$. &²4ɓ5d"9eD&N`!nga Ѵ6T]_g(GP$ѣXXB4jo9$Kʮ]ϒYXxÐQ64%]0 ?L)/R̉+9^Xgfٱk/o}nRò5$=$|'xͿ2Zj&CR(ض1^vIp]dۦgY\9w/3*S";6H++읙ׯd,v}[4Sbh4N&dzzQ̳rP~HJX@xBaN< _™k824{bsl`*P@UpnX[SvGZ}ÐFtYcttضa 8L&I$)vS.O{GqdjX֐V$O>)|Ӝ8<.5i2iC$M3$3fe21Lp R=>I=|ӯ|$1TDbOIPϳ;#rir?,_:Dk0`D{=RiYn6o~6m5MV4m1],RE `3t] b۷k|)h4m;hedEoET_EQx\Ķm GC]^x,\ ́Le{!=xN'"(`i}L64y k3:ټ8r-ty>{I& $I۷cާr(J~-6oG*gvȞ=E 1}+( $h-[&/<C (ko&>jC:=(Hʬ IDAT4T*eqvJMNoFdz!J0CE5|F!fөl U]dmrh 'V|C#(׿LLTE\^Cy2`Ӧ=2Mq'y`S,./sq!^yu,ˡ"*k ) ds9X ]lՊ|7jrGDp=u2eqբ9:J2 Ns}b(0^B&%y$hN<v^SrL- JDz̍:r)*$I2j;hݾ FJ*Q|_ IyI T  6cll?

 ;Pݹ ]&^?sh$`ښ((C4l6W**.pp|w>eF2rH6 膁Ycu*## %2[ܹӡTZ] D1TM M[R)<%2=7n|=xo8:Aڂ=R,NQ,uI)!ydufg'ص}O?NgՊ@iN~MS1=tBQmtMM5w <5l[ cʷ@PQPͳjeyQ4YYyc~X$)Hd( D sCv0^.~^('K%X_a:o7Bk>oDx\ Py?ƥK).HoSFwa~NP\ltu,cV臡. T*Ucal۾{ev'L-{+_eer躊J mk1\jm& ӥ"a0s'/SU ,Iב Зe]ֽ{hIOUY:;˽EL<pGIT pGe Dv>$ [w&=~%,0MVZh426g(Gf˼K#WEc˖$րO|lٲJA"1'L'A4*qTx\'}<24 A`tf4/ kvz:ssWiU"e-$)!O"-c"(^ONբYP߿K<LQtT"'0>ӯi2?<[yWb,b޽zq(/9±xUR Se* ӕ b^ǙyQ~' *D"CIBmvU*fܾ kHu]b4-1 NI R*8%,K0LS駟fbbPX,5rRh'OHi4rF*%J |4x܊p`koBauw:Q^ƛhJ۫,.CUmJ?ӏqmۏ0TTuHߦ_ȑ_`qkyvzMEc}}H2V+errNZ%7A45LUEe֭yeQJ&ɋ"9pӲ @5MJ*`Ϣ..đ#q"a.qE6j!EUQC&߃v^(2#u0Qй~~EھnH7CO$hJ%ǵkGdttYV2V|FX%LmЊUubH.'O8[W~WдH m:iI޸p!@yrX%V[(C.A{˗`z&cccl| {pاx\nh4{ݾ@"!d ,-=`ii# mVW8qlSW4UDQDL8l7dǶAmdC jxna0uڒM 8`BZԱc|:mL EE[Ǔ$ٳ>|t6S*5dry,aI(6 3?0O"}n2xOrI*%3Junp]ᰳ!A.y6BUcۃ>$,2UvHTS < Av]$yqz}3r EW(J$Y^b}<>T۝qLyd O=H8 *r0-#lm/N"]cBlvLNR+y=ѓ$nۥoǛM~i [(ZT<@Qضmb./Oo@s]2)w&s{Wetϝ;pCJu"ccEo?ѣWlÈ`Zmݻ09{mЌeYPn0wL;v(in*#*^gf8Z^ #L6UE!\<4p=h]שRTyX ޱP?;Ǽ$q8`0HPoMӢ"I:DMXl>16##[W@Q1M IP(4Qn( )caHia\/7~04n޼mz}CyX!YR|#\Or~\]nWy=Ʋt*lR جI\UB!Rnw͛Ǚ} ݂XZ:O\.F6'ٻ!?D&SXc||;} YQXv8n@ub|Q[lM["D'X'1"eߧ@۲l4x0?NW]~S^{?8xi86-nLZUURYf2zyרV' 6]1HQ Pfv M`q@0PM)4eVV7, C&#*hH(u:(/ӿCl|FcLL&ȑs b&UQ.) E4ڵ/)8`iium۷o!I-~H` Ob6B>_ ʰ'0u6rA 58$lr*m3Xu\<Ii hIki Ѡ .8¶~}8X*qe02'yò0ނVŶrIPtܦ^ryD1l2oV)r<qMSհm`Y1!ZK8DH$pSU^MFe.~FQ֍B_RmCcN:騔ˣ$T(x0žg8\addJ%Z7sXpp-[#I=zuRRuR)`Vk)x* lI&c2b;׿aK%fwC=rMlq] ͛0 &4{8N0P\mupHTBQ͹VٙEڒ&`#ԛ7αsa *$IRiBU5, OE7¶Phj-ECI]3gLfIZǟdfdK*U =}Zkt*ftt;\ϾdR)Jn Nc&.iQ"q|,,^oMNǓx`Ğ=OrE8cOr՚՚XC*)6(c(7/0M\n7n؈bU 4MR!W}EY9׾FOQsx7!qTL22MavTlei&;w>̓oQS,6' ֹ tehԤ]0 )&'266$WͦMrE2B Mٴ6^}/1Lqزy3wj4J:A:QD l>HMU1- ɲXeU+=Yfh`dt%ŵ5-/ϷQL&S'I&}mA&ARB@X䡃5y]dHkTuT5`Ʋ$l[AU[(:XLDBZ-J(N$<Ν'=~Y)eu5,${عx臸r ǻxku Yi&'gD4j19y U Ikt:ٽhj0mΝ[:Z9>Fck΢(w0Mnw\ȡCϠݰ{~z}TV1Mvx`|>ɹ_ npHW1HE"ry޶2:kt;.w{=~[+ pȫ/p{IR;Fd2, L&P_Th8oS(4h6~ U}  R:J"{gH,F*!2bR4!Q(Lsװ,mӴ2^'xFc3lcYҸԦ۝GQáY[PbnhlNNxٟRKTE+WHġٜedd[$B [`C/"I26-h.]3wp41 "\}uץ?|$à(\XYg~(n݊n3^_ K ټdHdH$!0I$ضMCUU> =T&uv:հ#kQ(UgcLT4y>ttZDUuTuH3=}\WFµcIFG')j$(S?((JM`Y.i?ӿ71 SHضTI>a ZSBCQǚ8m6v=BJ*avw^\V!۰JPUᰃa Y]]& 4q>R$a*y<\A&<4 ڪG?B߶`f<0sM$XZeY{]lq ]?jXYщD`eEf>Ӟ&&~<mK%b+\Wr躱!y 4DGd9, F$P%C:-0=(/=pgXGCaramT&1--2X*l$mFuGnt\32;w. IC, ӨzrVkŖ-uF- U*>}ZLRHAOٟItM#qwe%hk>o<El@QzHX^$I&`JqTI&i).\x% BlHF}t]%Z!]oFhW$#EgґQzgX>yr.GVcye%؋{=h6oF}OpsG3;jOit߲x q˱YgܺufcrÏs>Nt]FQzz !8@ub=xx,'{=TEA MXO/c*Xh4@J$bRL 5D1M:((`&R}u;w 5cJ%QWy#? 2j[Y[[cv03BR'N;7GwV(04MG,J$xqttiÔE (nūWiU|' 0,LL hܾ}x92,>d0X¸DE",b"ATuN&.-P(Lw2. zd2Guo 4TUјq,>.ʩS֭bh~_ }ZE^~tд> i?f8p8x)ݻrI}pNr,<©^ʕs!YJڀ T*`8Cơ"ea6;BJ4i]@#u&jxt=EP5^뜹60Xmj~Y׵p9`unyat([xȢ(lB0Mm((f9qBDI45,KCӂJ1MIn`{<͛CFug@m7ض(7޽s'icZHQ ,$(}$ҌWe0ؾYHҀLFߗ0 -[pۡ꼉iA7n5Mc0Vb$no6hR_*fH:c=%HPQIl/|o G#ܹw]1t}.6k:##; p]z}4ܹRITcރ9r7xicC ckoa{wx,RO6aГe0?2E90X\d< m#}Mre S;pݻ01-M j!{_ k9x6oL.eܸy`(Ib,gޠVe0Xql>я &#BU X>?D$v.d}׵J71Cx nҚۗ|Je$;SRqݥmrЫbVn,LS^ q[xxq`! ΑWH&3$i$BX,-`ll_D%T5ڀKj`PUNgNpgmm`xdvnVgJ%^ %&-7zA,4:Ml"R Ხ>`tlw`vnG<G_F$(1 `6(w03Su]~1^yxˍ@&\Y]`*Ǹ~ЇTAD.%fm0@4DAm/ ^qRx}v8EzKަPhh7;azK1t) j9'OΐɤQ,KC*X,PA[Xx!L*hvfsu DZi4Fm8,yyswX`q8 @ "%JT,ZQG$ÊS[RqJ[ocIcǎ+]_[hG QE@Z`﹧s:tcHWVMբ]<맟{4WQժŪt6Q!<,cN9pq3 K%A߮ZE" i6gl; o}Dm,cM;.i x@gf&J1 6/fZq.Z޻ڵ Q`VVap\t}BE}t/_(JiVI^yΞ=@U[4L W.m^^f``rp4y~qa?*P,VMnFIMߏ]CUӘ>3jkgY:ԲY0vY5ک + 4)0 v";w>N1m4= 9n)HD6|t@BITφ m04&e<Ŷ?> n޼ST ʕt::ѡZM3t:ut6XXFmgswZhSFuِ㏿ð1͈e!G Z"-G>OػAvOѨnfu_ QUFcAHjF:!#uY5]X^25-BQdn |+KDX4#F_öINJZ٘rYÆrni$ nPvQ*)(J;|>rg븻aH|oeNFGW~$LLCd ƍ+:u_9cct] L]0/;(\>m oBEIlŶM.*. IM$ lڵ(rk:uA%zU~Xbqv[epp%0}}e$IGի2ݮY .P.ŪtDQi,q##+(d\ʶMiRiZb7NCVygHW * 4Iym4() 23|r>O>4^|tnyj|u~Ѵ6f YNI,>O9XQ#rhB6KFQ'^$<ƷHRd2}J"QUNN''0TǠYRYG:lh6g.TJ4d߾O122JNv˗aWJd_|񋿇'0 ROȨi-t}PG?L"…?um|M/x<(Bgf٬q ۶XjN<__`bLJE6QԂ>N?,u Ki9J%^nEHF3ML=V ݌nqpY_'_GzU@+qwbJ*QcP/FQH{T,bfr1$&i Cirlۋ#_Mk21l0|3OtZ&"kϳt[X 8m'+&(ݏp4;t:5Z%|gBaի0Mk׎!JL\W^Ve38ܾ}t:(FMqiPQbbE>YWΞis9F*\}yňMۮ"hG6DCet`W pZ,3Sa.R˒kpzųrdLuF̩SGtZ/}۸BZQH J6n4]Hp]2s1|'tAQ48pݺJܼy~84+Vdrr'k00Ӝc(8hhZQ08G^y䑭dHr}<< Bb-[6cv7 n:%<ώ֡\ x?/؁;N7Fdh4uVWdHb*E.apd3W/ NS9x Ξ%vD30|y'U8-ͶisG_gf%##G?m40>/O2)2?_di6^#hhc.nI4)*t:c.#e$$B&blԢOsӷ0}M*HVcz$e{LFc&16ɤqd[m`]z1cWv(JD"LM ruvt:M֮=$I4*(r;O.WmGiʩ(<=Yj@ࡪ=6D$!kw^xݲPM1"k$˲p\Zi?&Ph\D?-ʘ oXyT:!MMr]Z1iQ${z.v}%B˗O255͛/am~.\xf$I$r9K52!a077`<,ˤR)EF% nN_drbBH&cO10<,+ .%>_avv&H"v}MSj4Mr9\# Cj(v2$QD#x*uMm CT:^2Tb.kYhPٽ`"qQuo߃LO$+!I2(R.6rÇi:^]PIJaD&4l~MQVFP ̙3@4jeL3EP*el6CRF kNL%&Gyl8_'\yVz! ]wH522Ȯ]{ٽΟ=6eklF7A LF5 6:[o~bŮN٭թkb )׏ Euvj4m,+Yԩtiիo$bތ8G?l! kE$IfttqqV|cl6}6jtZ Vz'tTM_&,wG?,-͒Nghߞ]<#RׯϠ3qq׍ 0 'N|fNZ%`y6Gk1 t]0 .^8G*>Iۦh043Y\ZطE;QB!rgrT%(䇆xZŵz;w^:{RFEJ mMc'O?7^#^ =.]ANlT_\uiv:h؛&uUeznv|4 nߞf||FDZcf/n>ZYC&燨o$!{e߾JYB !/:ÈGy7o`~~ŪU;(G_4Ƕ,DUj*C]tZ&ʰu&acYƅ311J1/!ɰ~Z.\ à,7|~qؾ}/7$^=^b^_=6~婧H+IܳKBA1,ZJ>&!hZ4jA̴SѴNTգ^dÆob Ad\7ݶh6U Cƍ3aAbyʱc2nУe4Klڴ?ԵJVŶLIL&C2eIʩ3 凸u,$LO_b$M&QI2"J@0HOO,˔alYdI<4X̍9m̶͛9s"x˿YטPfUݪ$ed-'~ /m<_ql,aZtEDrqc:N߿J8B~ ۞aj>jxdim"EiG۶׫@nNMk(H(Ȋ3;{׍at$i2;{0 u Yӗ#kF%$y;2oXvlj乲"ٹs㓜R)k'Ng5 mL<._ƢƍRUv+Nx $$Tƍ`L8 G./2 w卿x'ɳg6IFQH2ea>~V'<0Lo <<]0G8?Ow]}$ j|׮H$9u|ߣtصضmTJ?ާطQFGSQR鞩Twwq]Vq{~v=;Befggf#N2M$Q.n&W->$-d)V,q$blvďPllݰDr#bfy CYKE}ߪsxV6LM9Ν;G"LmSMS?Ad9 @ Ðj+WNȜ?rAbhhQ+~)r< BM?{IJ#I8frr#$!lgCK CC q:JdL>?=_G^OױssޟEo"~)Q۞ǻ|!0U&'{]y׃jIѠR*g\hPשƬ $wmF6e nXÉ3<˲0MVrǹ0U]\lL s׾cۑȶi4X8ܗͲ!}6kA S,FS8vHBip+X4 FWluAM V4 0hۼxsVq/<_%m&<%,LIZm^,Gi33$٬D&7?ȥ /jEԪʚlf ץj(fܗ.vBB w%,fTb^gxjF/y,A-P$G<c##C€i5MM``A;{-[ށ${ A277i$c XVu^63s cv98ufV ׋-~D}iQUY9>N_.G*DSS>t{z<0 ʭ[mM2߼KR6ޒ`Ν+R(_,R*1hwVYJ#"VWxy2FضmϑI3=ٳ!yEAE:(BZQ"v}VK%VMMэj5}Jbt`Y\pR~ràeD O$# $)JԴ(\8SG %5VVU@V x4#Җi"=ndY/eGxp]z;8G! "R6G/=QȿP.~$ߥRgn{ߣ-I(D7 -Clb*M5ҥlC*177GRv/N70 K5 d aHm޸TuT2IpaH4e9b$,Cŗ^|)Esο{;:y`|ͻ~uN֕J f2d"IF 3ҩ!0nzb\ bNydD}w9 'n;w2g a$zaY|Y2D& R,|\&I5J6yk~fy{/MvR. EENeG82b-%ͣOL`w:I3oS=-:~2}}dd4 ͗ggQu8j0,c*:jjyv~.83v<\uj5&EU\ T:hjlkR)HN9[~Ð莃H `.3N;_2 BE$dشi &7߀%{b=qCXt!J lbZҶ,ڝ b^b %e2H'S)iJ%^6Z3Y< w(EIENDB`move=1000;blend=1000;3OS6B1F+"?R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS6`?1:?1F8R'$!              3*7+2 -#DK6,XDr͚菙1fz#'kαv(ѳ3*(-TgG 1fh"Bh9ŃcsRbc!iX bJ*uns,u[lif$h-VID.*TSPi)ˬfmi)K,u2S#Y gn^) rs{--uMlm4iv{Fӧ5- Wn>xX||s ͮ^7n6nyÜ9\]Lix謫]x]8Wqg|Íxuۍ^_t8\7閙iTS:wyAᑉhϢҁ"Aiؘ9(L#^BCd~kު,ymێynpÞyC`mq}t}L*ðfB0I3HAwk#bùL$ qRue~y^[a t`붺xki\ku[G.P^daS t>& iHc;p b&{pG{AЀr.ʋt(س09/2w;DѤSS0D"+-lm<}ﮭ1L,rMu׍0Î9׍c `L!>"1\(̴Qaxv /z*P|=-=|s{n[I^ef+ʤ…q@Ap PӔԤFx۸yؐ.r(H HF$\iQ$F`r"燉NJ*LX\)׷y(۷Rsb*S 5IU >vltpF$"\1v: U9\ȠiTyѣԼ䧇џD ʥggϙ9FhFZdS5Ru.^^uHNT3Nf7ܬXyp+,yJsu$-4)S N*kl}4iګ-:lӷ,o]-(t)arz|쬱8PLiN"4S#JjmHai4Ͻ;Y^r1DإB>n#̽И:|H$7 n$ 7@Xݿ 0AD bI@ "ӷn;TCjhQM5tJVrkuVQUYE4TW[S]P'3)<۬=4u - DhLM/`I,My 0x0 mrθmql9mr,q\vMM/M4IQ4ܒO;b+5(rXD@r}Qbd5(Fr1#z,hX%PTF/_84#$4;*/Tf AH),ƅEgFhNbn `v @بԼؘp`R|мԘA `p 4f"B0Z L "`j ;U[]]]4:wUQe͛6@h?Yke<TrRCJ)4*(!/5..&HƝCN I ̌J 7@#,ؤBRjVbzTTcvpv`{G9]9pfZF9KC{{Xhj^ѻ5NV3@p fPA TBAX(4( H!goN*N*oNɎ:ckTΜ===*':elW%IVdeBVZalɫVMS&Lɪf S&afa)*upۍrmmt;w/lss5㖍=rEƧGDCDCe RA+h2/578!-FRXr'-)ra89P` @GXu'm UWM6禮3nlL4^:#&tvH)>!bLrʻ4c 0Ü8ˍ6j&L>y^djUIVZfL2Z ;Z/ %%djbVLjdɘ0WxF^+8Íqs;M1{npWqιn2fZd իVZjլdkTѵؔk"P0dL2dՓ&KY0`<8}3>yvuoIum&vi[\珙XXνrY6H&728x @(׎x\8l+㝴(݉nw ,[McRڙ'NHr+رP{hF|^YnG۬\`u u˖ov9i]}BgMԪf*iORfJU,Wt"GJb**mvی&j6Y2dɫ%IBUVdɫ&&`xF_:Ʈ8Ư6lx MUsWD!/Imu@_l #`0K"wCյd95-L\Ba5G&&#A`w+.R BVĦ ;uKҤ=fxz|fZ\ccGPd0B!z5-.6Dy{E24:TvVvX+tGNݸn72:^0t""@( 3iID-@Ѥ&Eݚ3g ܬJt\RPB)R(HCw(KS q6E50H`}EGaqm΍Ij꡵e߾uϷf+j$'2׎w-x_p"mS\PE lJ('BȲ&L.R%xZijfLJa8dɚkƺxCIBͤK!iM<W ÁXtF)C{g{(n)!KR\Ar-u\]WyMV ZjՒI2ZɂfS+Ý-%ZjաX``Y*VZdի&L#2p]a0< <#Rd ok0-{%HS׌0U`>pV`yiVMS5j28a9mC>B`]`| 6m-7~8۝`2<dq-@Jlygmum}Ei}ɦ\'y;l `` 8^0}3'<,qsxko]if߾YUWQ5uQE3BVMEeuюiu]Ymb֛c ի`t-7hq8= \u.9 MYes8_]mf,aK@) sr,Lsިbgw \BX khmeu*AE4QEtMvUQAE%Tun6|Ǎmux^yWMJP Da0q<ᨂ6~x< 8pyvۈ_<Ⴕ|0_)F[eNz.6nvƏ$szk}Ҵ|充ozi8u練4a`3VI2Z&KY5dkTZ\udՒfdɫUS+3VUÅxsmƼie릚g~8{ZiyUqs+cꠑڊkifYqƙ<kSjfkbb;3PntجxlTlD9zR} 'efL#<@vz{1/EyJ, *l( `(  {+;/w@ % B 9i{UVQFvnߝx;, @B o="is+4tuα:v뗹RrMИK, ƄhPRv) b5fH,ӸmMQ]߽4F& v$h8raMh듷Lqnr^5{eQキioEqҚn鞚cWUг3.<׍vۍ,u<^6Ü0<#WǍM8s;ks8+mﶸV';-\t>*8@`HRbbL`dHAѰZ:-)8DRbln%=% ٬oMe}ma<kZcX鞘VeYuAc8 BanM$!}ʘE0n(CX(x-ߞe}i\ۻmu5jn1v]om'p踸70>nR0`xao;L"$gN u 6c/T'X1 @n&D` @9Nax y̼`Vp`Ą{{ދ1ԌnDFBDZ5H®"BܠnHF7$ec8N+ b{^!"$wDQh\9F"̌lb61!C, "ѱq0V'Ľ z%CQXP_9{{z {{{*{w{Z/" RAФа $==@҃JT P <fŅƆeą$BIİtnbbZFP'1F`yhr%!N͊t*b}ۨ>^jHfzxTF>ۧnAIcS ܾ Ap dBx$!Keߞy龙祀,;;}/.^ 82 Fe1piK]>J ^MJH(P*N|`Hd.rݤQMUwRr^ۧ 83βt2I$2:c@0tn K Ăe 'P y$|P4,:(i:i$-$MSTSR*j뮫Х,67+<NAWoYsD{m(Əfw<{o}/Ϋ(]v.95xaxss8a뮹gd:ewٷn݊u piױPFtpļb9#yAT. 6 1iފ+ hrPjvbhZX H`@ !BV`t|' "&`2157 K  N LJJLH`A p 7f `,-L@IWEUڋm=!(j _:펙i8aa붺\cjaG;saƮ<J!/*+(R:/y睻vpzo1Dzyѐ7  0F%N{9{ވ(s/{qHNP) G"Є|hLPn(ڎ#,kOBmIS)R\$W35Is˚]-]w%J/z-z<1LޖR\~)hqC^Y殷Y4z{hgsL4hz  (v"*1M\ѕ%zJxѓ!e?,ʤb嚺tl&L2DZ ^mkZy"A'.]!Q[GRTr)k5#7Z%K{;ōX鸫>+?zz*\}a8tU14n*-"R#06 ?kQ$4Nip*CgA>ja`&1K2],^|5u]OZ֢Q\Zxi${^WKve(8ؑzyfcٽ \\Yo]Sdd,&ѱ^h%)BW?,ąeR5MLz$L2&JDQecᒩ HBd6TlӑM1D@4OU]oوճky|"]/4<1Ɲ]ƒ,)(hH"C0`  `@:$ K! $ :D۩Cm@hひQ(%(^A%3yo-V}* F]HY3 Hi.tdQWD ?Kо1F'@j/#E(JdZ[5=FjP`XH Aa!N!:dyf,ҟiy)#$$,,*& 0B'%"%:vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1?333333?333333?333333???????@???SK$=?KS@C@@?`F?`F?D??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition 7PNG  IHDRc IDATxwUirR1 PwZEE[`$(*(HR HQ9YPA&TWwOjԩSUo \'(5~LD9.<?ve2.^Ã2_ 8 F}8 }XW-jS6ijh7}f7@`iT 3*V,/j5j=5=i= ΁8!+bP /M?[SJs-R$CIȯI2I~9@k AA~A g L@S~xHI < Y? !y gZW#a$htzFb$32vF+eo@#4Gq{^`+>} ׮Н;P88 8s6{} {98/@Dڏ0%/1o$0ֳ`n3qLK`0k7 0 &fI~WY70{o)at1TG&@U<O)0ٙ 6@Owsنc1g!X0|l eLδu)P IG4؁ FiF4]O |,Fzgyi&] , asIk^^FS ڵN>ؾIYp=[S ~vojȳ_~);fЛ@"L{w%xbC(9& R 꺑83+W~%f3-aV]/n')H..Ay-&e+Wh> MyyrN!E͒`9:X"59]ty2h1LCSݤ= ,@o< ? ܴMHQO#$? ׇ}<$ 'S'yˁ^WճˢBHՁmMl}E?i6sny,D@uH2# /X|QIJ2w*˞.o[xr% kЃ>şϻHAox`>ޥ,]v/Rs>nO,3i0= P(*CLY_ m> x/ N{cUs?8fLb2NXEc>2xϪW'R%7$TC> xIEAvEcop(0 g >c;SzkJ5Ok+WVXc(H J/!y 0Ķkf ``>Mqm?g C̫`s%.pwϺ׳;>  ;0\ɩSdWh֥?A0?P;zu&ٳ,fn fR4-,F C+[1,ʶ_ =0æ-=`>:G5l0/hF%0?!B}Lw6y1E~p/Ƙ30'dv֭N!`_0XKNwe}[>^i%Ye+@t_*'44j7C > 涏YPDp}/YӨḾoWhl%5"! rTںuV5{ >CDH P~!ur7dc&CJ‹l׍m$ȶ [  Hy ?k3 \t73+ZX݃T W>E~U'WG 儥|QGYYl\G]d?FhCˏo(+ Ϥ 2ѯ?2em͵[f8r4,Y5|ft^r\|U(F߅1E!4C/K<@0PjCPǐӑHd}穞$sQ;S{" Z z KND x#|sl"'Ab]|R۔!OPk'{.HlNOw>~r1y6k2zw_ҕOj6*bHY ʏ4fhJǷGz(@ro`og6xuzy6]OoygH]v9eqiL +O`HX1 h1[G,Az=B^E\gӁ[Y4Z9f p5*(}Mx(FaJ; GH/Z5@pP,gpAqM6GHbI dNG;y U:,Bz6Q̝V-.5 X 7 Y2z \3Y5fc@통cAs!$p*9k4%S|º,# ںDy!RXtj y&x}NF~pf'(HuQ"*˪Twj< ٩ *J;eAEҖSC#fvUG&Pwzop^ _/cMiB18n~]Ot)rc۴,y*1*HHNqm- S  Hdԏ u1ft&x583͹\|uh"N@5g?LD/ ʗx5j8{rܾV2=OJ[sq=%\M ŠH4(*q'c?ը6kwKZs[ p$1l-Y.@Ba I %^wMc E?\x0vsu}ğ34nla7~ c0k64^jԭk5w\7D۸>ocarS]CqLC>n`苂`a C b&"w̳c/|9d4LO!CF.쐴HiNAo[t؆柔x3L> j("<~|16w.CYxZ/$pcxGӑYޣ\"#CȋrF~XYJGdu2\D'![8 腬/ SpvdiO?J-hafu@O@KnKFA%ijTisGQH}KpcS4BvU=u sPrd$AT$)lqQp>|@ ǡ1,B;Z~?֭ k}|?gaк7XtnEp|@0) ba<%" B'wY2ٹ',"no ;q*cgJ=<x{#ij96A`^He5$ζSX;Uedtf}j$ukd:u趒1PPP"!M?IlXߋ:oGmíȣ29QDT` {]i#w PA24p&QDu6mzz"ꮨvA'o:B{#nFҥ8w Wk`5B~\ 5ᄆ'p1Rۆ2,Cn\/ g reC!`pϋtbAoi,;Ѝ0%h!R`9OX͛@#<'͐t"8h<6>pMUn xAI"䡇cNݯ_7X/]9}~u]U]m'AaxbjUb ?2ET(Վ>pM'& CgNH L3Wc^ܱMT툍K?''WS= Bu/,^XOWİ0⮕lj8' sFzPXkl 8q))gV a!%k27rsbu88ӏWy;mhʉox3B/EV)>MT8ߠir]8DKzz7VJ 2M "`|]2yúQgn+XIRe$CY sК*7 yI !!F?%O#&8!2`d_x5[Ahz)p$5 &᳋=Տ%]2f#'qBOsv>| pB9 5%)ķ>臶 u\wMw"}BHӆX/w4\/XoKPq:ZxSY0u pBSMϲ_LYzgH$i4B5O@0.{k5 RAJ}d `†I_]X.#ڤTA7(? O=Yn+rƽwڣeD;i[fp e#fȏYV6hAh=q^?7G; =ˑg|T(n4@S!%5Fg-۶"*p h \7QPoHUO%0b*gl.8,.7 zFI\($}XMK:*[x-釜 ʖG<2w}Y\m*0m Qw@>R+Qi۶ȴI5軐K8}$aێm95BjIDAT`o^K[I#؟23."D*uZ:?@ ى . 5_eKH.zg#zL Ao m-۠0dN/n\V[QEu*跳ulp>)aM8R jz^+zvoR{068 V`?'>FVdD1*X;G@ & PIu7!K6aۀۑܣN 3zUULyDz1m>˗S#8pQbI>չ"ŽTi Z?JF4C8 aD|v }8 wZӪԂwUSȃ:W 9$@;(7 0 $U=F<alZ,E3%Rr>z]"{5F{&N{V>9g,Xjh Atv 6xbHyE\._FS-Į{1o%X-'<f \ ]Rk?-Vr< @0bz0^6Hk(Kćغ[ex EQI J=BDCbd2*Un+ŗbk1fĶ&~Zb̆ʕ uP> 2jNV>u4v0?<;Ud(2H%A-!^i:_ 5W~P*a[4ܿ' &Y)f͆ I wD+4`Өvae%YuZFu5f\p7th0\\x3`Y>b, .'ꍧ250TTO>Hn&63 8PaqƗ NrB]է沅b2pg/%8pPT[_ԄӲc$SM吴p\iK||=1B2nt{mٔ&a|s8Ж-%9h=dtْR|F S Lou|>OK0'qQryo-v Qf^+(1>PMDF**SVƈ#%{j];,k[s,v:Hki1ϵ6g۹f jW{'.L`^vi'I7uөRUKTrۅh`uZ~;z*q) e+ĔUoe!x2oa7p_o9񼆲2b /t0V]KAժT_Xq&;*@Wb""$^1lW9r]Ld ).0t\g'lWI CdX2BCsB1k\fr~O8l:qΔGΤ@.dzv9`n(W-kܧx <l)=My˃l?m]vl.NZO' Nh]Ck8/>hީpRTĿid%$k7bLALbSp;wu!T B]C!ہ`LV:0 kq%gxh$E7 ԖC8$^o@psX4pRRLU#n{yÛGk-B,N5)^=\΢̇x**KRE롈e[%Q{>H n ;T!?_aX ,OPU?=Lj gj2mzunS&<V!3͞z ĺ%@[{BxUai X$k?yhENӐ= /*!Ʒ'`Vx2g *x;! #KgyO>D4W"OHM_G8!_q]]e}@yUY߮$b>jcRDP'k62 m@b6qzUq#U`f1wZU7T؏@aQ6)xQS:@az:/'UdxUV) h^C੅, ;^d%&!:Wۓ t1!>|wNt$(OFer! 7y3Mo@פں+]Wc"c؞ ̶G5\WxKaP*(}x:Q>=av`YedeJp`&y`C3K2 ̦> a^7fLT c0gj+_cUjB+,d.C3( ^Sӱ\d[\~>3^|SJV ~&nNL%[eLNre}DM0 *s |V`:FS}0\跖c:3v9IVV}ybYȸӻ O=^5''dE>V0/y:~ +j-az$3 ,,w=J܅8DTx`+-- wp?/dù&R%71l*(u, yÒ8+:G8}(WSf#9qksuv'?#L 0c -K@h2@XP$8S)|%JFgfPnf7|uAR%{Q YOk,OwLO:JAV_h>|y<] ڻ(7YQ/ 1а sN{e 95]PNo-I20,b7TfذOE^$Epe>h&8ԂZb[T CPY֊Iq6x<)xY2/GǰWeeТ䶎8/V}a%zk-.~{Ǹe!^B)rpx$]3+%zY_"t8q&7I/9k&1di}/ GEUADG! Ƥy|0-WWcYU}T+} !$:f`Fwo]o>[̒Tm`Pvs97g^~E8}1G_8f:rS`N6*`}TI%;~f7f0qf1K;c9NL?-  ܑHM,Dr@e('W>~aQGqL٠?vX|hag 5|_@!h`ؔ c'_[&goۑGrUwýN]oFG| )ˀFpKGq>~Xu99)+RJ4">GI ҵ`rdSFܹGo7f/.Txis08f㘟&a ny_^'4- 8rIH Kh `z%~9y<$^_W8W@YċХ(e2}d6mW_N.ukLZ53/L8K0ލ0WsSy_^p5߉~BfPN5ĒBW#G<7{5TgJ "*`W#*o2Jw偿&di(Hk"Jۏbø'G:d_9٨WC B󸘋؏GQ~ُRc?G17IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS67a?1:?1*F8R'$!              3*7+2 -#DK6,XDr͚菙1fz#'kαv(ѳ3*(-TgG 1fh"Bh9ŃcsRbc!iX bJ*uns,u[lif$h-VID.*TSPi)ˬfmi)K,u2S#Y gn^) rs{--uMlm4iv{Fӧ5- Wn>xX||s ͮ^7n6nyÜ9\]Lix謫]x]8Wqg|Íxuۍ^_t8\7閙iTS:wyAᑉhϢҁ"Aiؘ9(L#^BCd~kު,ymێynpÞyC`mq}t}L*ðfB0I3HAwk#bùL$ qRue~y^[a t`붺xki\ku[G.P^daS t>& iHc;p b&{pG{AЀr.ʋt(س09/2w;DѤSS0D"+-lm<}ﮭ1L,rMu׍0Î9׍c `L!>"1\(̴Qaxv /z*P|=-=|s{n[I^ef+ʤ…q@Ap PӔԤFx۸yؐ.r(H HF$\iQ$F`r"燉NJ*LX\)׷y(۷Rsb*S 5IU >vltpF$"\1v: U9\ȠiTyѣԼ䧇џD ʥggϙ9FhFZdS5Ru.^^uHNT3Nf7ܬXyp+,yJsu$-4)S N*kl}4iګ-:lӷ,o]-(t)arz|쬱8PLiN"4S#JjmHai4Ͻ;Y^r1DإB>n#̽И:|H$7 n$ 7@Xݿ 0AD bI@ "ӷn;TCjhQM5tJVrkuVQUYE4TW[S]P'3)<۬=4u - DhLM/`I,My 0x0 mrθmql9mr,q\vMM/M4IQ4ܒO;b+5(rXD@r}Qbd5(Fr1#z,hX%PTF/_84#$4;*/Tf AH),ƅEgFhNbn `v @بԼؘp`R|мԘA `p 4f"B0Z L "`j ;U[]]]4:wUQe͛6@h?Yke<TrRCJ)4*(!/5..&HƝCN I ̌J 7@#,ؤBRjVbzTTcvpv`{G9]9pfZF9KC{{Xhj^ѻ5NV3@p fPA TBAX(4( H!goN*N*oNɎ:ckTΜ===*':elW%IVdeBVZalɫVMS&Lɪf S&afa)*upۍrmmt;w/lss5㖍=rEƧGDCDCe RA+h2/578!-FRXr'-)ra89P` @GXu'm UWM6禮3nlL4^:#&tvH)>!bLrʻ4c 0Ü8ˍ6j&L>y^djUIVZfL2Z ;Z/ %%djbVLjdɘ0WxF^+8Íqs;M1{npWqιn2fZd իVZjլdkTѵؔk"P0dL2dՓ&KY0`<8}3>yvuoIum&vi[\珙XXνrY6H&728x @(׎x\8l+㝴(݉nw ,[McRڙ'NHr+رP{hF|^YnG۬\`u u˖ov9i]}BgMԪf*iORfJU,Wt"GJb**mvی&j6Y2dɫ%IBUVdɫ&&`xF_:Ʈ8Ư6lx MUsWD!/Imu@_l #`0K"wCյd95-L\Ba5G&&#A`w+.R BVĦ ;uKҤ=fxz|fZ\ccGPd0B!z5-.6Dy{E24:TvVvX+tGNݸn72:^0t""@( 3iID-@Ѥ&Eݚ3g ܬJt\RPB)R(HCw(KS q6E50H`}EGaqm΍Ij꡵e߾uϷf+j$'2׎w-x_p"mS\PE lJ('BȲ&L.R%xZijfLJa8dɚkƺxCIBͤK!iM<W ÁXtF)C{g{(n)!KR\Ar-u\]WyMV ZjՒI2ZɂfS+Ý-%ZjաX``Y*VZdի&L#2p]a0< <#Rd ok0-{%HS׌0U`>pV`yiVMS5j28a9mC>B`]`| 6m-7~8۝`2<dq-@Jlygmum}Ei}ɦ\'y;l `` 8^0}3'<,qsxko]if߾YUWQ5uQE3BVMEeuюiu]Ymb֛c ի`t-7hq8= \u.9 MYes8_]mf,aK@) sr,Lsިbgw \BX khmeu*AE4QEtMvUQAE%Tun6|Ǎmux^yWMJP Da0q<ᨂ6~x< 8pyvۈ_<Ⴕ|0_)F[eNz.6nvƏ$szk}Ҵ|充ozi8u練4a`3VI2Z&KY5dkTZ\udՒfdɫUS+3VUÅxsmƼie릚g~8{ZiyUqs+cꠑڊkifYqƙ<kSjfkbb;3PntجxlTlD9zR} 'efL#<@vz{1/EyJ, *l( `(  {+;/w@ % B 9i{UVQFvnߝx;, @B o="is+4tuα:v뗹RrMИK, ƄhPRv) b5fH,ӸmMQ]߽4F& v$h8raMh듷Lqnr^5{eQキioEqҚn鞚cWUг3.<׍vۍ,u<^6Ü0<#WǍM8s;ks8+mﶸV';-\t>*8@`HRbbL`dHAѰZ:-)8DRbln%=% ٬oMe}ma<kZcX鞘VeYuAc8 BanM$!}ʘE0n(CX(x-ߞe}i\ۻmu5jn1v]om'p踸70>nR0`xao;L"$gN u 6c/T'X1 @n&D` @9Nax y̼`Vp`Ą{{ދ1ԌnDFBDZ5H®"BܠnHF7$ec8N+ b{^!"$wDQh\9F"̌lb61!C, "ѱq0V'Ľ z%CQXP_9{{z {{{*{w{Z/" RAФа $==@҃JT P <fŅƆeą$BIİtnbbZFP'1F`yhr%!N͊t*b}ۨ>^jHfzxTF>ۧnAIcS ܾ Ap dBx$!Keߞy龙祀,;;}/.^ 82 Fe1piK]>J ^MJH(P*N|`Hd.rݤQMUwRr^ۧ 83βt2I$2:c@0tn K Ăe 'P y$|P4,:(i:i$-$MSTSR*j뮫Х,67+<NAWoYsD{m(Əfw<{o}/Ϋ(]v.95xaxss8a뮹gd:ewٷn݊u piױPFtpļb9#yAT. 6 1iފ+ hrPjvbhZX H`@ !BV`t|' "&`2157 K  N LJJLH`A p 7f `,-L@IWEUڋm=!(j _:펙i8aa붺\cjaG;saƮ<J!/*+(R:/y睻vpzo1Dzyѐ7  0F%N{9{ވ(s/{qHNP) G"Є|hLPnA©u񑁓&GLTn@ET8|Bcd 4U bE,HpԨ a*4XNԦȎ4|$ A(X":(.p4ɖ,"4 @p BAABd]cˮ4B @T%  à@(hvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWO  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@??+3HWOAfffL?p};+3OS6Afff333?p}.?ZR$??U=XzV@?@ʕ?@ʕ?@ʕ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1r4PNG  IHDRc IDATxwT?,,RJ؂&jLĘX57k)wMn4FFł=bO;缿?s xq003{fy `y@;] gyc<@ y731@ o gyc<@ y731@ o gyc<@ ga:ʑln5i%*>0ao6?Or>N`ۄZvC y:CbLӠ@ϲ]o߾q<3uH PU~!g ,݈iAj*Gqk~'OƏ'xŋg=8+GSB q <'I"Ow!T*㧼涽(T<]?|/<T@ף1=Ѝ (-*%^z)<"!& Y{ҡrp9I'^'5erpY^R#K dQ\˝cJdupyc't /Pn޼o='% az/?Hڶ x1(Č(h']v0]Mtt56vYoh #w=Ì3{'i1sʢ͛S8.|PeY-5I CUYmJ' ݈rBå e& piv T:l(Rl9j W~ryYBj}%H˟I߀nyGqlܸ˶m(.$(fsx{}AB.b`5t [wk%aЄˋF\ie%]^4͕G;Cz4vk?b|K줩 8n!ݭ#ZBm6)ML٣‚Kˇ2g{??v,sߴ>?^NOxΜ9F)^2M(++㿚׾FEE kk72~xNOd3#fpDxF1L=^д*@CN罡xx@Kf^7ry¾cL*Jj0LFc,Dݴ+E@)RD\KH&رcYzncwpǪ7,TWWǚ5kXt)HX \py^U6 ˝8Mgo,_E"je+ǫP1Bm+),(eeq܄"d笠+RbJ%]⏄ޚ5^#PZVg?7`ҥ|Ga6mڔt[n#8"ŋOz ._ ./Y!鑜; u)-bI}!R"3l:wmL+GBa@q~:ǥXCڿ $r+"%؄I ɧ-@  ̙pý~!iyqc… ٻ6>J/'5\?' "9Wuͦ4E4Ξ{UN爟,}غ}[vak ]1D nWI^'մPVh'i&֯_?Yb_⋉F5&!I?uci "D&;ޡ 4:sqʬ5ncugI@ޟ&vL}s]$vz0>-uGk#(z.(ŽZf \pz|KOKK y$|9:\t:y:W S|TGpB w`FZA.a"yI-yҾF:[#腟of^m۶7|yCx2<3bWA]7~/tgfr8So~í @W#DZY9+.ͥl: 5T.U/#>Ll߾I&WPOLSelt,_Ξ={Y $Nkvy11'.7ݤk֬`ׇR_stM)8-xxh"6o:<(R <,Ri9i&GF /o~r~:,XkS2WÇ;FNpƛ$\ihs ;۾vhljzq֝f}ۭ g|5Oi+'H;!Љ+y4hx ۆ ˸뮻X~#lp yN]޺|-S?xpS@JImލwc Ÿ)))aڵ,Y. sVX+yze<ipj`C}- J%M4^{Ź?0 G5alE^O˓?gU 7wj.Ѵ/]^^O_O[o'|ϊ+شivxuرs2{>`,S1Loe<*J.Aip-_%>{ƌJߧo/Mh4FҗpI'R]9|4?8/ ^{E+**kg.BE^ o.ۏim|&IloG1v1]'mb Eh=b8ܱ?e^xSNrcfNr~䰄3)L?f2K,aw&oؤ$[KSQR4!4Z۳O9W'&HeSre[Elp{,}̧u YjUc /$=Cz}X_)GߣVrg Go +Y@ smX4ھc^FJ?Y3f~f4vy4x5?r+wyW|&󘞊X%zW^}]mm؞yjs K{m?oo&Iqa](_ ϦS9帋(,(EJSb4WPnTHskBn/2A}~vWU>twrՆJwMU 0 9X-|+_!pg@H%KP]]o3|3iۨکl*wY}c=NHo߂@`X0u'VsԱP,4ct;yӋ̚^2KɌ/RRX7eAcAf˹>_r")p?hGQ[6MөxvyzMfM6q ioo8/~ nvy&Y[=av ϼ ޼!ϿynwH)ٺu9mF݈a14˿J{T8z J:x#ib V_-#yj"_};W(Ij\}Ù _tN>r.BOR VķqK)@[E[V .B^zZ_]j${J0,UIq}Dc!Zn˫,J$oe{ϗ<mfv_t PS5)M7ձ*(h{m|+*doÖ=[ۋ&շ%1 ˃M22h "/2l)LZYzpWp߬Y`BqHz{᪫zҴA֌δh!GNRN='@̈n;ґ33_+Οa' u/x5(V  Sy9'=./{DZ.Bnjkky>gm8kaÆw)a.Og?KIqԑB]1SǞ!ֽط!%qRI-ng]Jmx DmV!]%O4hlIz1BTi,`&1t>ӧOz*QcۗKPXAQ oKO*ISk8;ƪjeW7}1=WQ"ns!v1x}v7GzJsFWiEe@I0ՀL$馱uw.ב^Sԛ),L,ʎU7^hdϤYaeQLi8?rZL#L7O4qz.]R^lனITм;˰aW~'|?P;%LS'楷{kHON8'-\I(כw(3vؼǖka*{8x0m I۞( #Mμ)Ӟ0/gje׾xY'vGUV:d1 iyoJU~:J6Pw} o:<w!JHIS랴ıMh\pvu.ض{mQڦkx:`  n Μ{_=--fOؒ:,3fj`#i߰CMA2yVX/- hk9f?h,g[PGJcB쐍*)Ot*݅yWvL?d<6|#ÏO=zWYr%W]uERs9Cٸq#p-<3fF&an3ȹq *!F9{ qSFifx͛{;ds-p-oUa8,zp3hjSէey^!.um'>uA_z k*Gz̙3KrQGAQC0'8 h&"˯|ihVeWǑi=tiвD|ȣQ,'Z:Yz5SN$m9KU屴2nD1LM|ނh5G1&)si\2z4@?8lQ$AkGQ$I9N|#ĪՈ88k> E:)/&4<>d(KKt+eC#yF°,8x$\s>*RXC?:eWs*O%C){  \ :&@lکd羍9BDaU[GCޱ9}>הi*Z ?.u6S&pI|ʒܑt}"^3 ˅&\V2wh'oջ1Fx>aaJ @։.^׸-]^O5T~#0US(P+`U1Bp*NGԨw!Ti_ dmo:\6ǭa’ˍ)V+[27tb}"8RzȡQEMh$5v"bzJ,]QwwJFo/l 8zEu!$~ova[Ty?K;B qIvf$W؂C4ƥ))tuRJZ;inKEɐ14$.t%!uvgrcꩌ8&$X2-I"\q;%5k&Y$=nḺj$&Eg|۩ ox_O,p9>! E̩T%Ңj}u&CՇ-IDAT*ev?ȓJixl _5&~O79t^s^KSw-#L&q*`υ3NƭT aI~l\p̀Ĕo'3:!ΔzBC:1hVrMIK`ԉ7QkH{ݣ%!.}4!{VbM ]lη5s OlmጮjXLTܠ()O'dؓ-?4X!^쭵+2;pHa7+H:[OI7McVY¶h…I:_W~ټ ۽`Ǥݧ}wbVrI{Dca|^MlH UWij&"+#CuЃ'/+gGU\%M_N9Ov/2WZk֫ih}AZ RBurnՆ@! ht8^CHO,)dU;vC=z+ٓp1;>bرw=eT֪Xg([МV'`r"֧nDq<BZ􉯷RÞ&9'kz#xtYp%AO MRh B>oV>! qi!r*ɏ);?_Eb>_Y-ׄSO^]G.w#A"j:ɓu{ק #+{iBk?~v4M̻I?=sf|q8iDGN@1$H˞қTœ4UI(D@uLir/,:j4)+v\=N:|kYW,gO@R*KWaN#0uQ/|܁N\f&ٗS]>OtSζJι4ḙ@7'%ڴt#Ks%%NQT8ڱҢ꜏HH"сYRlM{.r?fiVI4x>qRg=GCaAYZaM[iXV\k#FEJ֔=z4)*(`/}Abz{|9QX&KͯM2ߣ'SP#mahf@-)ǏyƏTb̝P,aGCeK8aY|=E?~d5LoJ&Ȋ@~MsDqQ%i8MDN=| #ubMs̓!> à@M BNe}#OMč1G E 4KUN*@1RB#b:C-Xe0.a1'V/4dpH?so|\6(Vv{AB$0tqMl~z3qY9sVfhj#~bDd Y_LBJ6lfHF1-;>`rG.#gc@g͹ R4NN$"l}?X)GE7t4ug,#/" Қ] 4HƙS9ٔ{1t=W=(E4QF Ĕvj,%A(IW 4PG+/0z<]9 *jq*L,!"";I8mfY[Y %Akgn1ަ4]1cMöGҴnXK/J9v' ݈fUMV5"/戚$ozp4{|v{gsn1YV'+D qf+RJF =..0N3O`%;NCnZ fB+hHLFY|A"n1rѮ4Y6l V >%Ll>#j&2ỷk?碅spJRH!Rop'nĬZ5FB7QU>5ۻ涽 uw=݄iuͭ{YTNhNӬ))8r1U1vٿ(XaYBSoUQ3՟Nnr) GC9v)_񧌋JROXFqPg__. eB;+ mab(+c*%GnegV{4\NNksN%ty1mDcQku,e <#n?c VWեqEUafsp:v( CBr\ߒf <+F"Fgw~np<i(^O e'{^EubzP׸9fQe0vБ\B^yWEUW]ͼs_#/9tvu٥b*=s"^I9\?BZ) ep}Ux>F'| iQn?Q= {A.a蠱*VIغMuČh^ĉCR(BJ+nƬ7$&7-NU7ɔtwwiL?P X,Bs4R}%Dca BO]=vbٙPZTa0 4`WfB\ϲ$0y eks)ߠrm͟HQ[(,UASw?껱R&ZvVv:oO(_Q?^H' 4u5e^`ؓ4z붤^aeBAYuBue-pM;j|Xtr¡nF0XHAPϩRwva$'p[y-ON>&/ SȜ#fJ8Xչ 8s0aj懥^OEInRY&:CpLGW k7'6Mt!ISKj0j&8Tw5R]9ƖlIv%=*J)M M㡿2q'cJAVKp ؐ *Xνa=u"D ui+_sgU2WU}Y}!e`.S8Ӡly;wufCcx~}\1"o_\8ŠZBNvO8GO8Uk8*dس+* xw{h§.x|Nhm Nِ% +\M=jmO5mGJIUL5u[{GIȊW~R;0xLS0+1Pƭo!}Mj379qb&OJ>8+U@9 i`1}>%xI;n]6[vv)+˕00LA$Y1jĕ g_AY :ز=[p@+dGLn:\)4L!ز=aaYTp$lIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ??n iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj OZ֟G֢/֠TQUZj#'Tj TQGTWAJ""*kP_ZF֨?֚'/֠O(ZUWRREO֩?jP_IkKZ(TjZZj*?Z(ZTkQQKj#Z֠(i(֢ZkT֠Zj#֩jMj#ZP_R֪֟5Z@$ $I@$ $I! HBBI H$I H$I H$I H$I HB$!! #W,WfW #?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???TL$?? Z@RPJQXQ@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2h/PNG  IHDRc IDATxw|\.E"ɽ\0Ɔ`lC vB -fI JHHHB]yw !$o/I(ҍ `セ%UU;E֌F|F3sosssяn@>E?y|OqW?b aO>ɰa% ! 4]fSp9=ȲBcc#+OGMW_ɕOE72[k1n!j+Y.?v,qe_f x?}M3-?2sc[{nDL<)" Йcحk44pE#W0h:L#k>@U_Y\o{FVVn9msYABa~GgZ~'_@wň<~[ }LOs o&QNLOs *iQsA5t]E73-J?y5膊gwc@}ea @0t yy<Mfw$YٲMtA0e`(*(5eL~9cPA)w.#N̈́"~!p+H(auQ%S {$O?y123H$DX   }z$vL"JC#L*'_Ve'91g`A @CFQC# }"~ avי;*4]e+l;Ӗ9P^2""j(M6Ŏa芆DmS }o7223jPbæر;뷼Ȧ]h{^@H[~sd*nG!fO\l0x፟uͭ{a|@P_Pu3aT=GPdEVkѭkn o\ҺF9QV2MWJHȲ?n_&amge]E?y9͹_` &OƼ0ܰ@B8<`΋-dEG1nyݱ# I EP:~| "I$7VC0X/SO1$IFBF$$ن0HHddYk25P45Eട(% ð4Sj1UmJI+" ϳ6YMz2}gZ ¦8P$ D'O /aY2YMwV7tRٶmwu~K90/gL! v )33gr۷LellI Zu cرg\tFi^miw +[xݹi_IlgoQ;6 ɬc5IkfR #!3mp.Z^V\c"5[]o_]l6Cf 1vѡ'?2 9}/O ())ᡇXyy[D@]El?M^'υӖS^2YVh񝢮76N G֝끿^!+`$))qn!`ϡ(?\4>ZǤyҼq#ϚODFA\FF Eg7:b0kɓ5j< & q 5z>ϸsPd%ZH g@608%϶9d*뷾sGk㰹ؒ0u>u߃O#' a йp2 طo?nͮn=5Y$$xkz`*yn_P;`3XŮ,k\:˱ ^C&xg6<ܬȲ-ila8v+ + M@.tJVf-"yunN-ekۯ%a|ΠՋ7x\(Bmc |l'YKP{λ u6lAgS\:Q#awⰻw4$5S;b9k׮eoj}f9Us?ؒR7]Cgb;MuA!.)A~ O?ka(XX2w]7dݓԠO7}׭Ƙ1cصkWk6֢AU̚t9 (.* Śn{<&;7>ݺFlClެ$v]֐uus]|>P$tT]E? C7oiaT-+h5 BW=mLë!X8hZzyQ;IFyۀ2뵢8V&iM,ZonooJCqEV$C@2 *˶?d߾}l`253^eMS4R 0Zݙ[lg0 8C/c]cǘVČwjCoD ++V0g~׿``)}f@cѽ3kMט5rԛ awV7m;Op( Yڗw/& 0"MSP}~aISkN?17sh2ZuI$)2.G_18'}}Ae%S3ei6% c$|,Rѩ8'eIdT~!HMP@ FO``A)*6t^Q 0bBtĸyHn1dve,W <Җ@ x -kS'tC"g[At &/V>T;Jnl&*6[B>flj1N:v1>{%֬YClzcv7H}7'*o?WXQ퓈DԡBn^i:ʬǝ׵Md*/םC(HyKzKЦȉyx ^:A"ܰY5"Z8e [u !DP['aG:}tRV22o{/0m{L*{<ϼW[CoVG~ s<ѱ%Sh+ a3[^z˗9g7\qn{U"*S8P -;'UO xCȡ8xnNH[%P0샖^V'se躕bLh2B]%{ǂ z$o@u`c׭[yP1|B6;r`sEgC]&µcQ7!$r|QC /:s1~JƮ;|&>+Щ(~+!: ':<5o@-:Oa$b԰m|>lPdt ̼yCq;= KR2@UmzJV40tdYFl+E*/}No$91+ bĉ -mNX }=:N\{VZӼ_Rp ?s1,Ȳ-XL2v.:j- dRl ә ABa?p8@D n5夦B7Y2gxY^rXvݬ~ԺQ y&U\DD a~_pWؼ=.$OsI$W\ww+ p:ܜW=ndݦƐL73 M43m=?Ϥ0tM [v8ꫯrSRRҥKy4iRFMs=,YWkUKnE] bGQ[>9p`$@BT-bY:vז k֬y:VX/'DUUJJLoʮgD_kID;ubiRlI4Y+`-z\7.g1^ntp%x;8p f?u'Npac6{{,Q)fK:yX6mdŗJ2bDN/nwNlo!K¸>kzi2loA54G3g< ._*͜wy oҼf ٓݖl/*vņ,ن9|lYE(o^<^(B+4~P+`WvfmY4k>"άYؾ=>{7z{I"\w?)H@5a>O/OU5[ѭmNN5}$j~A}yHH^Py@؇nh(Cݺi=y),cPOUsnmر~}>?7>hw~II [tQp#` ݐ/ѣ fΜ9|Y 幹4}pGI""[N[NPtӋEzs`Udyr[BҒ?Bffؚ>R3y;¾Ù? f͚7 œ; cկ*藒~l>CTBiv|9՞4iÆ ff8qH|Dΰ˶11t"C!K GjW7[H(F5ϤY<K BC ZNi[ow>kIX~nwv_qFz>jn6eGYr%> M-ȲÄB!6m^$Dt#YZ;mNvHOsG(X5ryhh>ICɔ{3g΃fs-[+Wr‰Pv=T=ύ7ȟ羙3! `޼?x_sI #'䦩߅O3>0(OQ~I$Ё<_½x\!wҲ7dX|lYWsexgxe<յYxq ?w7n{I`j$6Q,O~ZvjN%n$W$yϸ,OF6lOM8Xǫb`O~ I[nm;w.[oB Ms:a Y~=Gfȑ1 0( rZl,w?eaPWɆj6Ë'puW/|א)rZ#Mtſvzo>Koww.#4?oS)/ڼJonmF/'[?D0cPai~ٞ|4MlI<%హ|J1KEL0NW5TPWT-/;ETܧPO~ΠH^OXÛ9|چj‘ 7,QsgNÃn">y nsPYwr05;pѧ(e +".IT:w9!fe&ֶ:+tc [Ǖ Ϊil>?،ѾS¦؈!Z 4@Qf['-5S$%8R@RXXHVV'O䣏> g J.KEiYqH-"l w ۝͸xܹ?a1|t:n_ߟ2gR$I04+C"D($1lpiAQlB|-Uc=wڰ|ؿ?7wBӋet\}ٷQadA~Π^veƎ8@`ٕC͋;Ksٜx\fy}gf.*ǞbhQ9Ã2;fSZa iA E膞qP^: - [XTƍ?@[cGd >.u ^wG44T =ĐQ8&vwW6.gYrWX I¾^#a?`Ko"֐[O7Ig W̻'P؇?J}Qk9wNub xq9=Ydys;yJĢSp2ua[, rXepcFS^:w{WqՂ;qr[hj}^q*|FZORx͉AyPdhS (+ز^_C \ن©_%Hޤ.3@X}9=7r8 6'TD☶C߲ۖ^'ʚ-䩃,Ve(TY|,PSLĕ $۝O0*>Y3Cvrp$fޔnMYV'b2p۲+YY{kWǥoaΔ+c=R<zP;rmVu3w!as2vݢ4]EשnVtա0ӨBՑmTEes]<* &&$V6l[Mw&7kNJUYPx敀-_$TVo`Ec8-"N s ΙoIPgAf)ڔf5hA6+U|%nX@5BC Wo.[Ov>U7PS(es AtRհ !I-o})sj$IBVpbfZZk3(6xk_x-YD0&ESk]ǚd9Zua@p]:w(#SnPa5D}Srkrrxq;himsuci6H!DҨ@O׆a+ތ>^.S4իj9.a?mVK$B]rO'HF-{AOQy2*]0 !JᙝWl n2q6}WN>X4gEHL~k d{ u+0P+xK׽t֍1ļiWn˪.֡QsED; .]q?UeD=Y7߬Da/3r$$IFT|Ԟ:e_Ե}US !Dhv3$veqeMQt;h`~IV,?-df b=g~%IwftŢ92 Y0NS?tkM-X UkQ[Ǯ8prdMmg`UKc!uV]ӆ,-$Id|h._pU I2_OlڕW2\}wm6'ߢY$' Ë'`ݪ,mo6/)a|R2:yX{ŚSS}+1hl>AkO9 $" c7w8U0k7qpy{c OfdEtpP[IL;ߝQa: X\8u9՟RQ:m{ x\f5.!.kOBc莫˘wV~ЩPЁ %>2g^E!Xu0:; ^[; ٢:,%Ԣyx0HG71 ƍ9t_7TT5̎*\겆3wr@ZjYc$ ?.,/ 7dbiI: s.ロS¯3a65ݴ?DIL $mؒ(dInigdHf@/M"E^N]%$:1zgH++ބ=1\%r聦E7$lJ&DTKV|S,QY]H)Y[j#;:} vn4 I%S3h l,$OOvőtHc%{Y[g°) g3(7xQ{839E~hFMqB̤~ѻafkJX*aWцgf ] 0 )I!!ǧ: c)Ȭ[&mRjdں ]]׉u:Ꝏ*kp5c f>UWeX6݅]q$v2OX {HHHȊ [c4O|4d|fSWPV2w>V 4 Somj8rFF1\aDÃhc vŎ$ɸY>^[ݯv:Wv[J3&@G2 aFZǝ|g۶s.:@p g8 o%gfLNh 2k`v0t4CePw)#WZLaBx\ȲҮ,JԶ1oIt" I2;RSL}U V?/[c%\aP3Ã;)Eda*Ule~ZpZ"Eo϶ZdȀQo[(rPи6 㰻|o ^$@3XfBa?5-_|(?_)B?-y l 8҇:EH &Ot 9D* _Y`؇/w-5Jmnsq 56O_o@`p.6láz+z,yRLQ-5ЈWb)|[ !|2ݷZbJw&n\80E|5OWuaSl@Tgre%STPʰL{>sMZ 4&Dp9m8~.5D(]|7YE:9f)k+xݹ8?{=i 6Ɣnqf#h; N'EImtd{(6a݈z)N5gG:RZZ0P&֮] W$= Or3nl\v ͉]q6dY=˲Maٱm(B0hlhU~&q̸_8LA>FƿG}<^|z6m?^2s B }y`3p  IM(v$l>bGmȲl=+VU&EՠY3H4˓+ijįtٷhb8o\ƔM䩇^Ae l\~=2Gt#!#@>M I56 CG?#(VJՌoض=JA*w1yy[ٻw GFRd@bׁxV䲋B>MIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 gn iUZQDEJ֪?GU?G֠j j*?V#ZZ֢/k?j#Zj#QQ5OP_HHJIQD#IQDkTj ZATQAT֠(iQDj*?Zj EUW/֨?RG֠֨?(Z Z֨:"#/k?j#ZTQjTkMjPZ'GAQUԟ'Tj I?֭iUWERkTQP_EGP_ER5j*5iQDkQQ֟E?ETkMjP_QD#IQDkTj OFUP_H$I H$I$!! HBB $I@$ $IBBB@$ $I@$ $I@$ $IBBBBBBHBB$!?#WWmWfW!#?xꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??'& )CW@?#?#?#??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3(PNG  IHDRc IDATxw\y;e{_iW5"EBe#6%/y!8%8浍cpyM8@\#I`KB^{-3Ziܙ]!Y;sTH%BPQ\( PP !c^JQ}>N~ C@yR 6 (IIEsH@9u6<Ocywb?rr(z݈8׫I矿Gxock]Zi$y}Zzzl+ʋ?~nao\dGvi~>`id¾>{FY`vV>:O+pYYz.SYY@Qg@cBA@$P8Op, )mw;0LKHrZ s:~UUu&LG}ZnyMM-yw36) Tlz.;ܲ~c7gCZ9tM32 nHE(yB$z2siwW+g?K&aK힟8X';\ټcԏzד#J#B}c#/kziƞ@((B(sCA(vΜ Xx28RJan]R}y'Mnӧ$ cJ GJiHJ`2qX>/{ yrhBQT|KɦcI知tDN8>!4,#i%Ucs3 %LcUEC+,S/,AO6tC7Id>oiEzاLQ*"z(@&1%#&eXԃtoZOGF1tqnDЍ?~n~η>BG5e֐:"-M{z+E==A #=2y]XNi<4PE7 ‘Sեǐg˸qc^?5 !us*D&E1mBȌ8N!?<(q䩩y ˳xS 4PE(H~o4FL6 `[gp/#cpd^Kw|mW"TXVI` ŒJЄRfJ/ Gah(Tāa9W-ߗy8^ݐ/} @7 ' 1lP~;|v. ;'E]8nzQ|hTU~8~Uk4?rmckI`xxSu>4p 0ySV`6 tk|Q1mmfŴLCa:ڬYcun#J -^?](#3{aRB^%O-u‘`'ڎuYw䊆n GB:ys3a:BM.{_]p@ⴧH LIջؿ[ʋOOy8rPU"S?Y8[oG}eBUfČN@D"DosO$W.Q`6>yFA̝;/MdLGش =7#C2o!q% _ೋ p8@Oo;-sh{lPNZP״ڦiؓ?6z'|~[o5:)clhK.fl~l=~M7}8,}#Fʖ1Ç]j)<-פ5a͚5l2ozuKƕmɖ߅iHo S1[Tnu:;llE'>ȃ>;+o>t頯1Nj pOcn?sy\R둬DltoL;/ Û-wC5oǚ5$:KZRG5g8 r}d'ŝ?Ki v 4ڔ ~ރ1rvU'WDɊϿKs SZ께Y'@.u9{Cx>^zi %%{LJAmvv׼ ?&h Mc'A xiey-պN_Y?pE >DJXj[]zMH)kM MÌJv0x:|ͤ4$];# Ӯ d~N΃]7؍Q$< ng2oI}KeT B8X#Iog~w`8;we;y#bJ$,_]aYn/+-x=9Ǥ$MEg@"ij;lKMΙzs\k2*'n0{}i yimi?I^ꌭfJ-ՖAyWkIi wq"ꪫێ&JjL[}:bb횿pSQbTә8q"cǎIX $q;_?9\@eeT 4FD@D _Z;갍qSpCācmYUQU M)D$ǯ~H{{;[Ѝ $Q8窮,1%MX' %K[o9-[ƨQ/ Mb"+%\4Z$Q!eJTCq<*;t;Lӄ7_~{ix&]5{fmtք:u* .g ԟ5k ,p3k,yh^Z.FL@$0_4ZZڏwGExM>~zl4H{n{シ-Ho/5o+# X{(۷ . ;v`ǎixgh\E#̪sљVϽՙ;uzݘq@FAo:yu?z}~'jv,eTS=ԷHj V@ Ν;mh:DOs󹅔vTs,HiܖXbUۿ gE毽1eʔ!-Iz8O`U k$ȳo9蜮l̙z`& HOa 2) .2~?UUUL:/^|!'v! %S{ȵ`L!!,:sՁ 㡱^c/G)2_#o۱7ۑxʲy0Kۦ]I[khn?b>8Vs)}s]Udgɝw믛Yr}z3K #H9Qo@J8ܰٮLj{jl=-GO*&x EEىVZaB@i^wz,TO앀P qN]Ĝ!C<<Ã>TTnʳ} guR#YYl[Kι)%>s4ڕ߇Wj~?B(Rw/}BUdZZZ_b~uu8oUIe=P8˰䚓W1 ]5q6/2B(Vw6F40N_ۺo'cݽO[n81UF/cݼw׾?}Whr']4 3nGwŅt9~"GF#"zH$LDGџpP$Ȗ]>Qug}سgӧO6' /~466fmޑq-5߆%5Aq~8v5vN$"b%K#:։USIgO17lPͲ,[tYjUQUj26'q)%{2~>kl yQm^b{v!IVcʧ tZ_/,L0|8z(s?Nk1דcnYڭhY+'_2AmӞx{u֟p1@qcpOl܌6,زeKta5>p$i1&FjBjˁc&@{W'HvZ %my3 2>D",3a&+ `1 =̞r!s\d=-8ڼM{9Ҹ'd%i>aD!n /`l c#{rfv%\I>}[-j x]0$uS1QVbʕH5i, 3;Nj`Щ딋1Վ6B[h4Hq*//aP=14Lץ4@( |꒒dX̜t.vnPCA'CQJI{WKĉ'6a(-Ʈ]׿~vǾ" L V㜴LҤU;{IFbL? fL}O%N2jLm&>r o> 7{ڲ%[A_.g\=k}q6,1$P=aB!뮸d`GsX= &qA32`EA)446yFMb}L/ S'zR4CD~[:il6BAS5λibM8TT 죳%Yp!֭KkXS\ eeǃ_ۋTɥV&3l]C}H؊0씚";inEQ5fNwQ^3&.H{k' BPV4ƲSõ^J!_HSH IgTDslKgV6%N A(1K 'DXtt5Ѽ#!TUCWm_z{o"()jjj+Xl_| %}Ǘ1%Jv{4!*KN8m+@Jqlmg{ AQ^9|Ay;IgReXqkƺuڇC4<>G8eB0ݯ۲+XءAW_[̕dҖi0S:ĉŤ1-flJ(/g_}8q JhѬ ~yǎy|P]g*/K^Ny9f6Bfi&dLLp4!7'UQ)+gӎx=~@Z^SsOs{e0'@eJyXʋ9Q}tfGޔ`tmi/QZA/A]ƦM7nܠ%zI( k69Z^X1*L&[I  ^42QH)#VGfukrHnD`LI#6H*:ysQϓߗǧf^‡R6h>꡻ohD:ضmwY= GKHI0G0ԗ"6Eg(<ںmᯯ)߁nata$3[ mfD۞gjyr<^ *~ `o_;(ش)FwPq"w<;nvz;z;m4(\u k׮[JRp !'u\#U LǛK/3/4w>x4b=5DYYvp5$c׏כ Yh>!omvÇ9Xrk17f㒓l'ǛGRW8}. rK TU6w;6nƍaԅf描@g4k;Y}zڎN/AJ֩QQT|W9כu!qgvS<`f6w k}FN!q=)G[ij;L{W]m o&5F_ˬd2()bϡMyF 1 $x]^MCKF.N9cZzZ b̪hB|,=#II/_+nAm{ghyGU5 *e7yfUb. ifOHD6'j:/=&x0 |3T1r:q~Ǡϛ<E)/PNYD}S.^޳daJU6PU!cʸQ}lYߥ:{ZvJig:~OM$da9\tC`6z\C;8ܰ+9|ısD a{UQZTW*/ivռ̟q  }Syv) psc}LعL31s!3;uQʭ҉h((DVih G1j6;ߗ(c x rKH, $$o ZsKK6 VFN4sE,aU\!"c;zZ;Qt4JgO B9:xDov2 ! gYa_z9 \Hc#)-{TSzIDATmWXl?3YðD S_Nq~)^fP_αTCJ7CV";[ڒB^N1[M¤&3u|Gl☭ӌɡQ Gw0T$" NmӞǑG L)'g}: ;ڑ01s`͔q%&! !aRWNIhXޯr+Ke% pµP)#T52 gWA^i|bChuN[”(*r<M&V" KF[ڭLH~eD`g ~_aX4[A3@:n2$V.4,R=f.Z:N`TASǟe53 rKSG [SP_F26Qͦs)J()Eih FLA͑Wq9ȇ|{-Mmil=DcaGksG 4$v#vՀ/E(dqnt$Q{WH>SdiQUm?M_'P_\S;Nt#7hn?BcaZ:"W\"P|kqµ$ t!c_ )ߑ媋`Q=oq4kpY0GopM27o`ϡS[+J#Yg\'Wl[`ӎר(Os{꧘@\$tNC 䗑/a޴E KsZvI`278qƽ.:zZGBXS.)u$-ۛΕ?0>/^Ɛ,jimf%pi! !_ fuK?]ow~~;0tB0RJ^tBAQ%cg: RdRvCWO }:qFB:a"E_+mc*(bVH8c;[‹-.vccSϓ!um`gX5bZ;yuu꺧 xb5VfH8ec sn5iPj}̴* s=-rOIGs }/O @GCNRZTh(B۶"pFJԖfo~n 08~PΞsKHS bsmKwNrbąJ!()ttaC?R@6'_Hih'*֚ M_´g[B_`O2]51m L0ӕZ4KY\UsDRzZ`LJ G[OI' R0&vz[V" ';R`E %&{XYfS2uv{^2J 3!'})HkܹW0j6yŴu?ʼÍc}wLΏs^/Šiiyݣg>cXq[=uO\N1(i%C} cf;؜Uc8[YCJiuϱ3>Me8`*]=-tA<'yLcYHxuSL-hHRDC9\[s䀭!U#0EWO+HObW`1 w_rx#G1S^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ??k TZ_UTQZ֩VJA*UDTZԏjj#Z֠(i(EF֩?A##AET&ER/j֪?QDP_QZ֨5Ej /GU_֠ZIUZZ֨?jj Z꺨֠(iQDQQ5OP_AkTTQEUR_TQ/$ZU_G֪?IQDAAGH֪5EEGP_ZFGQQ5OP_AET&ER/֩?OUUAI H$I H$$!! HBBBB@$ $I@$ $I @$ $IBBBBBB@$ $I@$ $I ! HBB#Wf#?vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@??? $??@`:@B:S@?~L?~L?~L??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4)PNG  IHDRcIDATxy|TUb%6 &`EAV[A>nحNڶÇi{V{^piԆAQP[dQdG@}^URIԚ@}OUSԹ{9tD.x՗*2e$ dټa( 6Նa)6`b J D"]!0ta`YIׅD"nh eq~|V3eGAt;4`L1,b*@P)*;p]1/1Jpmƴl+OeV d1o9SiuG$G @J]&T"Ζ`avې_a|S3$}62avuCDAׂ:R´K塏C!Z /(hrʨ/f{9דsMgˏ~v]}`>!%AYT}1:V^]قCb#%R͹]>tH6'DM!%"(C) @;F]] ۱¯{A>u' ɝx` E}{K- BZB N?fRRSHMM!%%Zjjkغ뽠{aꂲsCJY6P\q~(ޏ!w6oюsdę}2- EQP0 .s5N݁9u'@膆fhA_(h.|mUTQx:N;'yB^\C2ReY@rhV^ 5P%i9@ܛԐw!P M4ԣGDFP4Ym) G vs`7BEAUTU0iytzh^"v|T5  KNRKEQ)8A[ R~ UT#-7G?CQTTEu7Y93Lf\v=6[65U9{"]y\GMg)?puKR&K Aǹm}.KE^.hsϕS%MƞF[ 3 %W?R):e[ gԕH v6>il?M_QƝ [VIGtt]CӜ85'M-|՚Hq<`fm gʾ%F J(B}ݖfsMS^GB|65#H8pb;9Sy SQKn|M׉ !@۾ZGiH52շtO,vey `R,I !D385a:EG8q曈SPΞ ]eIiHc3Ř8zXVs 'Z5g9Z;b24E{qʹ  ;6]\>~.Giᴛkvt'N͎Qz!01.r ͗ENfgS{t w7"FܯZ,jl&1>%"8l'Zz#<2>K0GqAS Xg>x!:S[g^vsEQUyJ*Or;`M=< a⊋l[N؛-WrLaYWku7AuQQT5I7F@X!uߎ0 c{{PZuSTD/?y@ $C+`Vqk+ZA8ip>: v76.%8-$'qC,Yt^NME3ȇ~=c~X>{; ;a&gK %),aSE>[I9Q5%`ʕ1{ @JsCNXҪ;N<揄2:˖-PT} ~7nh!yg md x<ε }>44 `¨Peee>]w݌tML5 ]WY ޚax N5u95*^֯-Za-6ʣN<)RF!U󿏔sxmo4ԣ ~D5O?t͕5#6 JhƁ;(8{ ̒F!UךWRX9O?YSok ئ(ˉ,etZRmsΐH{8WY F H>a/:c~@m etrc6;8gH)9%yI ݡa9. 3e{߅J0GO^5d)E/:ļy:=/ +]eU9rjW7J=Xy@Q ?cMHWw qs X~i&ǧkYNuM)NAH=q&dŃFvUCCCc!P4hCP^=7FͰ93NcKm<j&L/^;n8NtC^C?q+HĄ=.pu}̥(*jv3u86z vky/`o56TՆ!u;.W@r!%MzvZKt8P,30ޖG>V٢?>ޭ9J*,=y4>WUuFKox=N˯H5fu,B㋏KB*u$lMuGN\sC!y;w.%%}Png,c4"I@QA'ƝCԟLZi+[=_lF)$c^w9..)ѣ̟?M e3 ݼy3/y l4+rgc Jֽ0G f-R, 0YǐRǐyFtLy]JJJx;w;͹Qn@_Q!IK 1.JNMp`P^]sIPQ]Hf@k^.Wa~ҡigʾe`(Zɾ8Ķy3ձtR-[( 6>)+7ހE`"fw9곇NدzF.-Of!VJ>C{yIkBϥ}Ÿ4JNZ7_W! .{ЧK ÜU3ݴXU֭[π[[{,] O:M7}u}b) k WYd _{@eQ3=ڵkkR LC@ц4j%TO~yL~dfΜ?=㑲5 i 7yDžAy@9wvyIWYs9lr-[[0&{ſ Кg}um^#GpuZcH)@HPmYR<'W膆fYưާXc*ki~(,);W_v2y+opz]ya:cO8kɠ`6 sGOӸ$5LSٞ/چJρ6TRPPLjބh^A,+u裏(//^oܜ;͘1?ȈtO {.lRg3qIUMq744؋ $Xs>NT5 RzLT f( &'y,>Li瓖͎"2zgd=i(*!ܿc w83??M6￟Zem:܎GsY*++xh4iƈ#⣿dR,E?0)aVd,+P'7m GQlWoKD74^=L]NluŊ+x|F|E׬Rr=Zq..Vf[qFBV_dWMqH-MO/#T+47N< 5;= gu)f.tgu'>m-欷`Wj_U%)!44D?^ ~ 8we@BP|dtg6Icf[<#K$ԔV^!(uW4z%X pݦڵ.E$16yd|؆҇P,BY`s\DJcSJ&!Rkmt^GcsMF<,xۜB_w!T}{eŊC[[ V1P@PS_NUm1EUnӗQݦv({F]:ُ ڌ;A||+ R?SXXƍyggpzVCsLDF`YY$o0qpq:[8yv_ȚHZLR{?:#<W_VWC>ڱxri;0Q/.?[~L( Nv`ͼ[Q8>7?X,1_Wn}im̹vmXF ) isR^HOR2 cvG-FJ*,rW87g?YG_ /`N~2[s_84ȏ ]p-foZЮ\) Bʑs]2txDϗӟ wyA>3y ܉7܉7)(Rl"@J#;*ʓꇦ>C^Xwضm .d7{|.k^f~91vD1(6T"1GN+} >Zn|/WѺ !o4`vHk5VFF0sNV?SOQYY<>lj) ^emli00s0hcH)򆅴ekjo={|r]v1  -ldrb:`2`o̖2Fʾd>WJwY{-Hmk-x=gZڬa6âI󅌿}_inn6Y}\3wy'o>\OcV48MWCSף㫼GO۶[o`=Tq<ۍ/:<_ =RJ>K/B!Jy`QOa"kf HG}D~xǫ;D{O{ OsH͈w@^A.Oe*CΜG}ލ`+ƙ3dr"YH{,b0jB\mYsPnEgK '= `͚5՝õ+Qi"pe8qO?ъlYǍo\>uňBwuCȾ}yɓ~7kgIt=ѻЭx+J7YG[?p Em7(LB1ral] !e@\-/VbӎhO:FgĔ ,aW4˗G\R.Y03?u:| jD5;=VZ>[o+V;3r[,Y\~fM8wg9sfePE5È =9Յ1|梱^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?9n iUQDjZZQDj ֢֠kR?(j*?ZE)*HR*QDj*5Ij j (Z5(jATQ/j#Z/֟E?(EGP_A֨?jGOZGEUP_GUDUD~muQDkOj#_ZiRZj ZZ/֪*ZZA '֚խ/j֨?QMj#j j ֨?jFQEF/(j*?Z֨5֨?ZiRZj (Z5(jAIZZ֪j I@$ $I@$ $$!! HBB$I H$I HHHH$I H$I H$I HHHHHHIHBB'#WWf#1vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???yy$??E"@bNӭV@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5PNG  IHDRcyIDATx{TU~nfx " q@JeZS$nRImcbᚍU[qlݭTQk4( 087=3LO~n}_O}{ #)n]ʌ,_>oŪUk8vw,ZTQQz4IEs;b׮Oػ3N8M*)z;zя(t]eiՙS6~DIE_04.\EUzzy yV֭K#;"Y0K F#))`5 4 ::7Oz7 sPU-?E'J%}LL& +v`.0mTx0?245M'?ȱc~=$N"&̄dyЃIEÈa1P5X,Å3L'(juf+4@׃OH2an8r$?(&NIYչP7kbLkHwvp!蟋T5sC|duag$EQf ,V'&% #r8L±cE1}5&@ rGw^s>.?04U)Q٠Y̌cXnHӍh  q-I x駋rG})SO s(;:m{u; XP TEe& =,Dzr5Q";=1w.>,^ mmQP$&r͍SO ?8h>̉'766n:_t蚁Fh,<7BCC01~(Z)K,a̙0i$0 t]G4|qlۦ7L&I&hFww77UU;d<7)W,f*( 0y t̏ ݊$L46FJ8x dڴi.===i4R)9p`lSw}7@Ŋz *>Е< (L8c ja͚53D҆~寄q;1]s$l ѣcU+6o&k׮'jR7d~]<So_^Qgͷcx\TDzD'A5~my٦(*=^Ӵ[( Q64Fv)d AM; OA`Esy l6Kr?K7Q7XJܞixVU2HPIyjۊ\`Dz*@'n`ׇtG`*n5͜^k}୨jeU?] WO\R4RAiZҖXp ~{mH$ؽ{w+1P%&eClOe2.\P'"STMknC ljj*scrYkd̴\ӈi:#d"1첂 d!uuuQ)P9N<|:(jIg޽dcyNA厤`SQsYG:4`\RY@pQQW( b[0u M3ʗtY9N'#92dsJ1W(k8>bX Wbh&,tY@sΕ;Q$-R*VÇkWg.#nՇ,cDrPضMgg'?O(BܡENEJ[[*/bù,AfJu;P̞={w>6o;!^]5PNA%jPQ<9&nق{7o~_*K.GG0f݊ڟ\up͎"wGU(SoX6赵kill,n7;fkaB=񲜿x>"XTtр%,_^x~8 .z(^}>15?<?t^9yr(BGG1/?яآ N+@]|ҋPTl4~DD2mf6nȢEb|_]c $OùG/ݎp,ԹO8rѵ]T< RHwa֯_Okk+r;vM](Ĺ[U竑g,~[ "`oǎ$IyԤ<96oիiiimvؑ JaV[KmQزe Vb޼yi7x3'ΝHsUƅ<9mƊ+x9}f)͈W^]Yj=7.~-~drJyg :F5=L_+rOEOF{G*|__UUQUxU)\F-oEQT2vp\EQXzgV&%S%r&MD*b۶mfWC< )H$ECQU9Q)4qyr߿sС׳q,k{q}o{6ō 8s̈?sdzqf 0bۋeY~z6(JDVZ 6`&oq:Dgϙrn BQiEm1n0 qrt ,P}-[V&0*6]-±t_)Z~1x]D#_]\t[N~SPY22fd/sK,;{0mlTFS5 ɸ<S&6b4bF ]3q=CG9/nt%y. sDmN%)69"By5.whEcRbӕn#L3.! sDmc1,C 8 psn)whE22DEw^X,c}&ϲ}s9[l'#剚ގqDt]HyJBxbHry>%j`YSJ܉R/?iXuOF^/9UZHyJH*ݙ}UkΨ?7 /ǩGSj|!,œmT_W',õ>՘}^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ꪪh iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZR#AET&ER/j֪?QDP_QZ֨5Ej /GU_֠ZIUZZ֨?jj Z꺨֠(iQDQQ5OP_AkTTQEUR_TQ/$ZU_G֪?IQDAAGH֪5EEGP_ZFGQQ5OP_AET&ER/֩?OUUAI H$I H$$!! HBBBB@$ $I@$ $I @$ $IBBBBBB@$ $I@$ $I ! HBB#Wf#ꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???=5$??r)ER@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6NDPNG  IHDRc IDATxwՕU&kFYE$DA`rc#؏}vY~^h!HfF49wpܪ2ouWݺ}sOH>dp!@zCU_ifÌe #VŤ!DJ([a̛qy>v' y󁔂If5CDCtt7bm)m|dg:wsY:\]˒aIgK-] r ks-$69E[u ma&ɚTL\ɋBôDnBwҢ /Ct?>= um_V1jm)={Ŷm*kp20YgRV=(!#tq֎97qn̞["²U1q>öM 3B$"j0-Pg±Ect3,AJQ;ԳZ~Ri?g-*kd,} #m=?nRJ #i5[[+We J] rCˡBtg>tFSHm(K$usL;%f;H]Jx;='08MhMC ԯWUמ<$\͖Bqw9TL<[mG| ,ĶMLK-klNk슉Y8L$j~J*3=/[sz,"wĺa jQ'V_8ĶM,Ĵf2,S0;Kw{aa#4}r,2lk}uDs;QѲ5g))%-u>ItWo+M)+D[gn~3]tlENO#D"=QBH#5WӅeV%Q#e*̛qZƥ`wFtBp yi˘3ڻ8+HDžswZ[M+l-Ì"s{kbYycszG=Ahl҈jW[Zf2*+q3m .bټF5K.Ƕ-6o cAoΚfGa扇E%3lzVm:CÎ6n@=\i[;2^;. a"k%Lp2H$MRـenx rƲ+G5I$W7:3&/f%{;!2+0qM躞zjwo+~n聥$%:nèmY&e11-M<MSU]t'ntt7Q۴[Z Y\=fs]u=Row5fi`̥~~?>JkW#W5V^KwM+iG)/iE\vI nNӴ؎UiR!4N6+mGضɎWՇDasA@JK?2@ O]Ӂ!ϩA8OWO3]-\{WRz{Hi1B q;VpӌR1i>@y9ʯ%4Bщ߹8v)HU>1˯|]h6Ŷerh8 vx ͪ2wѼh P 9턣w5bW}VsSP4M]״?x-u>fG^C;k G+Ǜb7, P q+hL00 Ӳ>߲M>:qaD 3B(܋iF sX>C-qehNhgh>]~CV筹/s~FYYB hT'8'yܵ#0 4 L4 v{7v5t}띍"jB^ 3J0}89Xm1[;ЎPF M4۶FF/MN0qYm[;]ǂYs%'Mah )vBgO3KׁDͰza֭$ h,{>_Ϗ;)q[:uuo YmbrDtDZ;1-Ѿ\0`>H/~ e73ngn VoL9^QAHUz2w5Q_m[躏Ջ75{YS88KXMGOmc玡''>i3&/b|&I}sbݪ[()ߟCWoKʱ}!PsqrH/%EG ,%lKN:>n[}|L7]灚-4} [.&?}|ܦexa4chR ͻh얎:i{ s]lضIń Mqϐc{A?HMa$)) P61vxӋ[ޯ`WlK%8fkij}kc۱lRizC˶xk_rZj}Z;jijh,Ehq5 `n lK}y#D$s˘gUڠLrr}$$o_gyax!y&;h8/6^Zk]m[XVgz4P|U/t̄X:{ASIS*U!b=_L pKzGwFm,98Wf:ܴ$Cf7kZZcZ^^#-u'zcc ^8 J S^:b^TxrhB0iX2,UөBXN:VWјZr EtrS\ߟ|*-yks,uGv0ͨj`a 3-M*x8Bu?_瑛SH[g-/nܗ͏y9Eh6 {ʛ7,]6lQ-=$BhMz-2g$Irj^Gznں5y>s稺(^?޼\kC^ϋ%,ơCΆmcYŰ"t rsd!cKΌ SNU&%'O^ܜ"ZrU?(1ޯh@Ų׽__TN ]s }IEG:''1(=})O)㱗f[ ) %s I TSeQYecBekld思#fr]fM]܊}{hlf|?|ΞfJG^i ~o{Ͽ*u2_}}^oh+my9v6 RydBЊ SWS1,/aYej# ->Vc2As`gb\yzvMZ(?V 3B_8ܼVUAqo%u ف㝩kL`لfXNL\_,BDca$Qus먪DYvhn8<쥂<{/OlbP41ϧ{W*mñNnAsf 7CO`9Μ@G#1rvwȩ,1!S'̣)sW"`ҜLsj5P&<>ꣻHH s/&<[?t/8[G@JɦxUu|>4-o4C.:kJ&PWwHirq|K¶mKEԅNO-U~Z%!͚unnN8//]ө?z 9c  XxjN?Ox'yt&4 W"[$'R|wv=ͦ]O+*sG$=Oc%}9|A|RqylJ>,-4MPvr0l:,{)tK+SR8)% (d_W\7cbG -Hnw HDtM_|A}A^|wk]UGsY~CG [Z wn_bY&!ڻWR/d-bLA9g/6>i*&nsd F:K2G%5Uzql3[{=]&H}Ő"˳u/[V qJߓg{O\돕$<_TVnFwyKCo'm D>XۑA!+u*K2_FUrͻ,`;?$DLjRjЎ/Z|SS2bKD|5@7ꢻKWO ݍD~[sTwEo ^!?^z)?F5`,x +,Y|4B ((( Mye󣃅g [|90w5Nw_G Ӓ0MB1#.)1t][._:OϜOssk׸u!J];}%DG@ww7]ض4OA!483Wp  P;3u6Y6-Gz$ͷ4-/ ?[{/ɞ={*E z(3 ~!?CKV1\n{颫N #Jaa!MixHI2oi^#-\tߙԟdz£yV]<:~_#̙OƣQb/;?븵vw9u:$0oi'l2(p?]twwMWw7w yj?H3761UH5m!j_Gtv#<>5k֨Bo>VS rldE惄w<9ݡ]"6g܎OG0` ץD,Yiyӎꭔ'h}1xh!+_eƔECuin\k:@|' >\V).1|HispoEsˆFDprТZydsxU MZpߎ IDAT>!ȨfPNTu24TmǸ嶏dQUVj@N +~nTU_+Wg q<*({ϸ6Bܓի Ќ"^IPH*<af!m<@OOYYA[W#jޣpW+B|`@mS=<2vlwGxYb^K.=m"~ “SDn N@Th.7FJzLD] efvVCe{4K|IБ1o3 &U!0_+'U,GJ~zrV3r.G\.Se[^jB2d P=Ƈo>K0PV<""KzipB(q91yB:ܰ~?+9:*&-@AAn z3s?'Ȁ%]S!R{rۨo>#9Xs7o\Yߺk lRJ%8'5 {S+M25bgɴЬ)KyҞx*O% 2i&Mw_Jt~tm:?}ix˝\L>z=3q|XWFq$%6t(@}zC!)-{{:)3)]OXδ8v&y%OçR|׿6g?3Lksw#AV]<.n@ NfM]U /F8xS^>29v&mc6j[ZuC# dZ%'"q˘,|f GwS]>uMxDG Qua|2 liMyܩRNj;k Wtl[b˶mX%=iW=rs CzδeqyʕlҐ ܜ„BKJDЯ:Y4Lv Z֮~H!<[C*JL2{A1;?Hyf^͟'^{}Y,Xe`Az/qTaS1\z֧mdV8!9#AZG eTeGx1 Ez9sUxcxx_lKWJYr9>_2ظ3Zyؑ~3x455|O8<;R ϻ?*;[v1~0-i>t-K'eJbliJReD#<=T^k1hu ^u61D(;&9;t8v6 X oN:Ohr¶m:5?1o9ض-L~oxM8c$.X}- rKrRN\tqr{r|~ѱAǭYr.R9 jo&xG#i{Kܹs%6h7pٟR>!~#n% 32)/ŧ e&`ZHUfEcz;v\}<#l[%aKo`ټ8uccM۷fBhL*Ťr!vj)AE`5ϊDz T H|5 {>yŅ(˲3KIFrƲ+B0lT?;kA\5?M#LLv,];v0B8a~c(6UMbT9j|Rpu^UhBKZ)m6"F.ɼ` 1ehF_H-H[lu__' ee4Q϶+M0(ycOe(-@A^ =}Bh}.HųB I D0`i 3cuŅ@$iv[s00-2l*_C  b!Q N]@\y]Se w7#Op?… G| NPXi㲲28@)-c1E`?9iޏm\fENgWЄ4QU!1Mqp7OSJ+dF&'3(y%w5fz衇XhQF+0穹Qrt?+&44Yh]P0(S36]z֝ضM'駫6թ]4M~ƽ:_6 tbx!rs=[ϼ!4$QWBoGZ}Ce~_Oߗ΄J@q[.:k-wh%Ֆ#[-%/x)ĩ|򕯰zj-[ &>q{gSi5jN ' '*~]gNdS02πoIp]2&M]Qis>i!J1u\rr ݳ٥41, ǣ WpvxcT@Y$@Em9%|xħ"({qj5y\r bZ%cQ9@(z}ZR\I(G/`5p] <)%ʚnW5P-i}x_W,{.hڽXM⋱9gL?wИQ#D(PIa*GYmR}t-u4/_\S=@`t'?x @G9cm] A>~ե4q[:H${I^5 tߡ9'bla˖-<)7 `p+Dt ݰŤY/θk=B_h"UUEM7I~ØPH::G9-zrs /H⩀3nGJfI`\CEE+fٲOsc)inxҶ*&U}=r9xϕ݇e,!UV!NӔ["Ap N{K^z Nu`wڰ5u) gptt7Q:fIWnw:!E#%kuY*Ǭ)Kt3i,ʊ'sWOd\+NJLVn9y~cgi=8nO]aFU{JUfN^ƊyoXVFv1}]%?qsyAIˍ fY0k ضevxϸ!Q儲IJ ٙ(6c&y,!\ Ņ uRW@0|6J{C]6<.EsG sarx3&/d_q2\施/ ;H.>v*kc|iE߸s8K))IJDUL#*c<ʦYӖQZ4s(-O(^A_gxo NUu;$vb,`>+^ɀ"o(/h׃j8zLՐtgtt5#jr(*(cќ6=a7hzu=2)=c!SUi 1lqqtt7Ba~Ķ-fLYp/V/ ~p|Gc 377lA 땗3ɴ&yHesRgS8pd;o&zHisv;.ʰ츆#l| Bx׬*<޷yhHY~= ݚ0$kL(~´δ-R1tR\8[.fqT̜^kFuW&|PZ8~c&TsR,o?8h<׆iœ cUu;蠟=i@LˠIeFta/}n>uR <J@?@47s1O\ R^NeV}ߥ`0mW &jlƽNg^/={@^ԗ-n7(^y2ضL$C0mYty:`Im~cI^?XMh}A*&s-,yq_ ǿb{~ )%Z] ĺRRdB0V>N]cI=WlcqŹw+=c |HfWּ|~K ?R'$W{DL=xzjw{ @:B0cBoƇt<C0n"O 64T ȝYv^S)Ss78Iռ+cpH5U9jN(όbuM,vꤽJ?xy|8pFv=p҂>&S_~GfǞ}!>c:zlh)$ RR4q%SU[M!)z.|l%\" S|fK.={G*jxqz[iw3q >I?0#&LdcZ' q(2/>v3%jD-[.6x]zDaDz)S?S/<箸P6GpJm|!j2&_P-,ex骉}V3GtZB>7nQPPHa~!m~olxOڔL BN >Ԑ[q0ea[ IDATXM,z  V݂@{#^V-u߉-mŻ'paK+Pu!$.z5hN@\|'jgeJpL29=5 |jOqoZ86_s+Tyof4Gp4BN]O'c :v6ldb%#w ,YlD>libK 41M 0msjضS6nndAsHUԏHp.AkT6naE(@|9i P_5 KmUaYϽkEPa''gEVC’ky՟nblrॡKwٺF"8+^ kuRZIUP4֌H#Dr Gt6| /"#%!eOHiQUwb[@JSfbEu;j_I-e^7[Qu÷,U䦪q)G=-vMHۛ/`X3i3xU39KHˤ!|8 9T]zFmS/=Pq ͡u7 &a\Ԍo 8U[ib[}n4?x@4 0scX>Bg)vq4ixl~T;aE Aӄ&Ѽ /t(EbHˮp%|4G'v.IAӄΞ9B`Q Fg.-m 32j;=)t-&Dhhɼałw6p[ڧ ÌӚq"ԣ9J\ajgłFnO@zp5O^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?ꪪo iUQDjZZQDj ֢֠kR?(j*?ZTT(i(EF֩?A##RAET&ER/(IJEAGj OZ֟G֢/֠TQUZj#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB#W%WfWW #$ꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??!@B@T@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7GPNG  IHDRc IDATxw|\ՙ>wzU-^pc^ !!Bw![IvC I6RHzo^$7ɖe:{~23hFCcI3Ϝ|H>BD}}b|&UGJ:ϽKF"Y:k#/-#;#tOZ.^)j$-- Aoݽ *(\48qD} eqon=w{d m"G8ܬ"TZ;uoohZLKS~Łb›|0z& yZml b~~cAP }fS',AJ:y.[vBH}8wۼbJ k@@0j>GNn"2Ӳ줣_ML'2eqܫV;3i:sNGiFBU4shjġ88|pusJin=DiQ-^_AζKk{)7h6l8it{R2p:8KU[1ڊY;gk8MWxܮ4`K@EF.+lCŸzvd 8޲'3=esb)LqGߡ,dgS(]Î]Wh؄]gp:]e0m },LA^ٙdg擝Q@n8ǑUDNf!>֚%P]>48RrIH$5e38Ѳ^"ͷc}KşB h=ό}̙M AAEuԔO'--Wi,7nI꘹Y@Xfʼn s.nF54]CU4Me랧m__9׶ XUI$f(5]CJX]I@ p8!um >ynXuN7Nmp +ѥO+e&:N``c)c?=L]b:3(H`7UdGR>ޘJ=bhu󡴨μƍ4MjAC ;T@S~;B5tǷu(N.EqL٧\u4AUT- KRAo jA~7 hzז58NTՏ}e3Z8!=-Q"6)B Na.p0ug2D"i5Kx riMMWp 9aזisѢOvlߜ9D点W!DՂU?.ƣAt]}Tr+HᥭI[0fY#_ӱrLC֘×憱lBꖠ醁j*45qeQrRƼ4OisOl(i8OoHiaxOYY&y^^[FXp;=c>H8rrg8ȀO]wJ\* mBq8#9sKڊY!k{AT\NnWk M;ؼs`}) ?%ظ".8t=[Ռە9?'_go[H]G"(C\o"w{yZmۨ#Ֆ^/kMLHuye8pNq9-:c_[8cq:\o&2xh/)9qZ9ѲƘ5 Hɫ=y%6 {\h81k*$#-M2Zoy0~)Y_.$;)Ԡ( M__?uf:.FP3省dmRǶ& rKԨEEq='Z5.jhq$m]Mw8FJ iٷuYvh"#ömGٿ?Hm.lZ;J#;ލ_RYs̤D(SU_ێ/L ,o0sށJ̗ Du4M50to)i RRXCan9^=)&:N ߔֲv-vnt<>|6if97F6ᴺ:-b"3yOmgޔ*j"9x|8;8}E(E?;Vd"ȘӃÈv>n"u )u&WǸʔ_ކ">8:sJ9->3URSV#0 Eyqs+(/ B)uv~μ4H4s~p_F s&L9Aj_`C   Y o6O~N)yCjGiͽҜTN)8DO >||~rΞ3 d]DԄS:zϰmzpv˧/fd/TNPʯLqEsZه@dnf!XyVbN[EyR3LAchJ'tOfBشƦ]8]W_eס xT[v=GϿfǏ_eW#ctZ_5ׂj&|񢒧(=FfUIsgJbvJIA00p;PGOt IkVVFzM:eB&V;59D_u|>VS7M5 [ fҾ1lZ4O&iL> pD~BaɬԮ^d1x_"zL:CEPB"ilX#qk;gRX*CteKzZK~Y?E`|ؼQvlT~:<7qaQ9 Ǔ"4NyM_ X42~~|ck~e&GNof^_RJ6͕WێM:gTHc,;Ë5]-'`"Z88CPRP8s׷)#` zx"Eyc:oIccCQ]6 +'%~o760eˠ'zFF [if~B]7E87EGT"#=E8ˆcʕl޼yl3 )Sd*#l-enט[?w| ~qpz:hi;J@G|6]E^Bu^z緦쉱Bkn8>u)*"U_Ĕ|<k|W0\SöġV"v0!~>۬Yz Kgo:B()yʊ3Ioț] _8)Y=- (VeWY);שG8rrgl31f|H^xW>A?AOgvy8tlQPQBGBE(Kt4ؾ(%;;2G¼ C%RCv7N?+3D0n-c24|!0|H1Ψ_tt|㼬bM.JwSW13,`+_GS!$F7p>kHԅpVΟsoK=C'܋X+ 87ehenktSWSR6/k}3gM RKqu1ɝ&U/`F2.qۖFZJQGOfգ>8ܒIKE1B2BAnM8u2b odWhvԺ% *ciեSCq0ѥʒ3DąХdrB4-8,`9\"kbFի˧G>B15dž*@AYly2Hdx\嬮*ͭϱؗC1(Gy"~ppp:)9n<<9ٔYS#j,]U>q22fM\I+BowdWoڊJK^3 RY:e _8_ z{|2 Xx7T#mL3l^bɬ׿3LR- =>1iKYMYmh0ڊ*=ύk焼I|Y%~KQ ׶1vkBu4iYvnW!ie!aCJK}4Vu|(g6 ڌ5x{ފ*)gŋR[WO[{ mm;ñGTQiGhqb8 S<\sA"g}}=Dlɬ 7CbR1r<.opN*fٞ_c_d"bIA cm !#䚅8N?u]M:]nw(şSO-y?l C"=PyM[o~vm8HLOG):O1ktDXfġjgؤR4!HÀ-bh-P9]WiIN:*yf'#Q>;r Lh6w\v 섣f}z{!>9}:bn7/@)o| MHEsq+ݡ N>HR0R]1U$TMY7\u;a(RĪz\n<@Y鳔qւ8bA0~A5}Q\6B$QUI\.[CaCXBPuA̖_6UҐnЍ29pHհ 1ڥHvH9b!ghjF,ib p ^h< 0?6 SnG4 e\~?Q.\F?A4ᩕ@[@ RRhd`ht,Ћ.ub34eQW:`5p;}+֭[}%w-鶞&Q{y^*+")Hu,Ҍei/4u +K&M|DpeR#qLa9[TG;BpiFlFF?aQjVnpmĝlYG|un6 ~xx3$3&j#<ޅH IDATV$Ȁ6mYR2GH{~ԇZ\vL0{zS^_/XӔ_ף$C@aiaFi♗K=G"L<i  >qܸ[DF +ġ8xq6R"hLO@w;sjf3g΄ 7Az d{_my{hn_}o3!{2QGZᐶEOpT=iQF(R"Ed-b]R ]U _.s~QCyʷ{؃w}z)֯_a66{yq;D #sF2RAreł둦/%y%H}M8K7BXL7Rtp8Q'B(\!?"K{rG.\@ρX|9?[o}zK⼞JvbYX=}x<V.6ތ(1W̛mcg4ti`&<רW kDo&ŕ7o/o6+0~Zڕv{Xe¨zy7qJs0xvބ7E/ TGkP!7;|!{A`Ͼ= slHPhѢY"Oxxkc.-ر#҈%6PSauLDZ&kZڎshnƍxi0sXIVꟺވ7306Ʀ]̘W'=i]}q+yg>޻<w|~N AFzL1jqiUO˓/5KoP/ M0Sbh&1tWد[Tng(O0/=1R~mxCgFթ% .Xȳ/G}wnɒ%q}vJvƍŽ?wS jAj aM<G$FSj٬7<òV<<ȱ&#)|TXY)Du,xq,9/#b|~? ye܃k}{ng+MO7쯲2N,bOXꣁU{QsolEJɞ"B(k|ͻ)GT7~=zbL]c]D],rR`v}_ .q_0!Pbhzސ_?&䪫{i;wdI >"`0HcH@$Rlǡbݟ+Vnbm6fܮ4:Ʊl/ɳ|5_|MBwY rKe?'nTLjI?tWڊx-6?!<詪I.u#Q~hĹjJyhx)M/UDrO5RWJ8#ry,LC:'mfVzeel/-0c?Sn|1.Bx#vyǶmi(ϛ|ymiW vy}>W }(&͝iDnl ?GGWo+iL>͓?c, 2d>~O|b=GK`ɓr-kÊ:ⴖ *#c!fiOljW78d1zQ5I0~#_I /ȹ+lG~T(,䔢iaRr5رDņ n` b;3-=G"^q:<ѫ'3 Bv-<`}AO4-4ZS#P?bysgUѴ%w>fܚ!C"<.A:{CAx7gg /_2W]u_җa_{= u95ꌕ8.6 `CSՠ)F*"-pq8\<ȗta#ajbUPQ2ܬB~#rR.rQqGQBB^2YK.n஻"[]w!y}69,/`O[ J +Oc7,Ty o3Kfx^[\)+!>@h~;e-->n3 &W>x ؽ{wB ш3Y]y{ q6VQiF?F} %YJ,sYt:{yqKrPc΃Pv3v߾tttñ>ӧo_lK]󍸍hf8MdIsŊ;@cOzhLL\jɬ hR3,?H|rݷe)q6^I>hP_5qL8uwJp̛7)Ppxܙ8Nm|eAo{[8byh`%7{bŦaek/#~$HxzoGFZ6HC9>G|A_/KK$E}HuX>ZƗLb7ΊK[n.L}>\CL"mFĪy /k}5zr2 :s=ghi?J'#͝YyD)SWQA_leF3'.ѭuj­1gڼJCJnӦMs]Ā#?w] =:&V͋-wH۰ چ'ee䇍:TeӤǝÔ&kH䇁))x"yYEjg*N\ QΡ8$|T:ŒaYl:莝 29XIsdb̌< 8#|)㚭%B0PDȷ~HFI 7 'ށklE}}=4%T4% gΝ{1NSf^FC\Rr1w7'}Dee:})9y0mL+)%g'}5灄‰#񅧅jP9GNlIVF13 ^ O*OǎB/LFZ6y^@p84!UjnM8Sk3Ǔ kA@@=m: G0`d|YİTS !oh \| 1һ9蚅k׮#eifϝE0J| Ges F0i$΀)x}U y&24d0kIdE%EG+(wyS't9摟Oii)|ˑfYܮ47yT4gJPLCtx-Y+ҩuK:9Ȝ(qJ k 퀯75BZZ&OH{4 4ZQsJ:'BCexMBAߨ"ٳ'zƭ'>䩳a/'Sgk0~MχZ`4Jv*Kt-Ɇr&^h,P#LXS!K8ն`Y1Q,$"6u.5h*3sbgRCIxPbnR4&#!L] z[̀1tI "rvA@|YHs K+λ+-fLXFov5y/tSj!0zd\ R’Y94HbՓ5K ժEdtVns G3o`֎<_ Kvsx0J +ĒY~fĞ{Iaf'}?Vi`%ų֓O%ϴ%qpɻd1֠|#,j`DM#049L[CqT gj"#;/0f!f&@hP_9i{f;66vh wĶwJU f-8.6+VnvRa&u U  p{x|aZ]fgD$?lfL"xȖjDr,4JB#CjԸreA;6%'8JNbAQ)H&]Hvz>Ņbv+VnbÊ;>q:\ݑmMP7EPGfRt:6EAdh53i<ɱ{9|0.rK~'/Å"V9Ao=-\z*Y;è {n7 GmL< -mPx}68}2ruͩiZiFؑN7zJGi8$2nR3/ek6qgup n\.7c8ڬce0˯isP*KF'^jꉪ|i:Ez0 82Ҳ;APGB Hǎ<9 %(2lāc[RԂ㼙kyoslzBBP1GՂ"B$JdGxݮt$P8x]vu6sϳhe)GM \ uNƨc.7ty2"r$u<]鸝Nψ[ޤ#@Qx2B5a;՘P93ށv^ J KiIDATB̉bZƗN-`&@vf+!#=YS㇢;qGI$MgR[>bT8*rԞXL[YE($ƀƦ]LYǝ߰cM}es4J x8gSvu]'i$M@a^+>PK8ʊ&¼R>{7aǜ(@  ݂pMx'I8.T-ȩQ6Sk(NGP>uX` CըwYCC7T^A&vsi'*,5H {?wq;=!N֒?3[z]鄼?gpXPPqX5Eq7YL^ N4X}EMt3@ iuo#I6}ߋƈ#JyJ3 JYnkL"r,T$5?ޞQ)UCuttͪQ }Mf؄9QQA(2%Ʒ>Vhc.E}\=Yd"3\~Ǚc,Ӑ5ߌl`G7B0CY&9׎iT-@P9y✜t*Fh"jgL/P0+/{5w&pSWo@4WՑAp|F!0~م88qP_9]FՂt$q(õTTش 5 +A̟v12f|>>.u4]lZ\MV4epQbfF;bct@O0C9̇lB(vXEFk&i-K rKPtO4F&u[*Қ*pP(hǿ*?()(<9.L AՇv=Łz]b <@ Eqarce \ 6idݔS iAT5炨Ե1-<ik(:{ ngڰ׫J(aר46L'aFhaokQ)gJ@2cKSZ`_M $uC  ̔˞"`TR3/ˢ-ҨZMLPqcc>XJҩ>US?2XKz9Vx ̟vI0RIBO:zN3f!N$h<dDq~j#'#cz$Ft]î52}wDFŃIZ ]Ɉc1" AJt"%]ѫJ,خB| '>nRc* ' G,9̱( ߬O<MfьQ#R?_\0?tu:PWXxd֞7m?cz̮6a`C!IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUr iQR*_ZGTDT_VTQZ/*"*UEJZ֢/k?j#Zj#QQ5OP_HHP_QD#IQDkTR/j֪?QDP_QZ֨5Ej /GU_֠ZIUZZ֨?jj Z꺨֠(iQDQQ5OP_AkTTQEUR_TQ/$ZU_G֪?IQDAAGH֪5EEGP_ZFGQQ5OP_AET&ER/֩?OUUAI H$I H$$!! HBBBB@$ $I@$ $I @$ $IBBBBBB@$ $I@$ $I ! HBB#WfW #IH?vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???RJ$??x0@5AӥT@?䶱?䶱?䶱??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8j6PNG  IHDRc IDATxy|oU,Y>$ߧ/l1 @ $$$lvf20%d#xsCLLBOɶúϾI-[jd?euwUVׯ}SwϘAٳ(!79\}SO~z4g?{T\x K2\,yjy{ʋfv Hi"4r^a^Jwp䞴Y]`N2$қ?M lOU@kgژjht=K8k8u25d߿J{@ZĉBJH|h&!S;惱}3reDJt3avN#Ikg_:rki߰ ћ#!*@KljIyh_>[]yVC=x:IWo3}c'a?HЖ`7a ;1 2.? BXE((u vvTW,t `wF~ Mp9.aҫsc6qSJu`ߛv^!y񉩔6ҕ<"eHqBIAB "Pĩc;FsȰe[<*53Wf?cR1e4ip'ۓ7X+>ú GT"DS4E%۝?8'`g_MEWc?''ݿq5D":H4QP@h#c}SX @4͉CsC {DB\|;nW6W~э q>*}S#KlM^-1Y\~q88N'$}θDH  ]=M8T'ܹIlEu\"UVJ(9_ؼ:@tZaDx؋Ӛګ \ 72՗)nJ'Z:6]יӄTߋCs"4MQlCX& ӴFp$L8}S#q0yZK3G[\ kȺ/Ҵ|q^:0udUx4Mir)@ ]uG2է C((jt]u4cɒ3C̄@MݞPiF2AL<`I_=Ė5D&,u!ɷU?i;:,ݎ?E@ILLC0uLS0 'MS3$`\.LJɢw-aH:tIjc&{]h ^uhv\dN@ Y }홻"&}`,n ؑ)aD0=8!{ #¶TI y}^`vc@TVٿ`"u<|,Z2FƳG8YOWo3@Wnn%b`d XȔ*'3Jk|*xN K&PBAA\,YA"9B*M3r-4M rX`o:8nSMަs~}3h[i4wo+k7:Yx)hW`I oAW7WI QeKSCz_^k;g@ "(Bau̮X̩sٳ Ca?.WnsK-l'D8B %s94cI͆)@{i[Qٮ{B9R`Pc'3aJ9b|^`{yu̫^u.Iib}ۻOVD@Q gpEW:rR^VYuS[n.@4n7n֑W2zmQ_)1AY\ڧ~R[Q`](%AxBL^z)# ? +qӘ ݖ@)Y 8PUUrdۮ(jҝ_e o y;9zVYÐCNVngj4u+Å>5GՕȷ2wZ LYYh(GN=WCU(*i/.#ϏXC3˶ơ]3jͅn9{xk zf!DQ2>wXh>mwlTMZ4h>~9ph)'l=y؊)+!)0} )*'S9v1^}$: i]k qɺ0tۍFT}:_jWl1P&Trjogɒ%\xCwlLJm|K_4M# Yf z+vmtyf} 7=H+c3j թkH\h!8|ՔY8g`~7/q/`?g쏶mƮ;{֭pSPy p;Xxػw/O<Đc$24c߾}]͛7cG9Igέshr1X8L>5k\%,J.Y|mrӪR>~erբ꺔]s5GG,qz_WesssA|ͣfJY](]vI@>㲴ZVϑ%3'|J eE\YU6_V/Lk\)ۜerMrc|&e͇Ҿ/j/r뭷w~(i&>?c?OÇޯY&5V5U+d`W% o،ZY^4(o,+siSYrɱPTP$AJ?}*dX*$0gRG\a֢y5ʼnjC>~={ظ1| Ї>ă>HU5|q<#طoKe =LtWd׽*۶mp&0t:ΣFa^9B(1χLALi<zMB 3ټ2rHi|QWn ?K0DHe2vt84~~.߹;vc>.r.r}=x I!+[=kO"3>ބ"&M, 3a(0tMA*+Y=;]q$^y"ƷZK@Hz6}$8YdRmnj/kwLǍ`aϺZ(ί'ɡo¼rLӘX)$$ψ kq9L_7E\sxcщl͖8ָ{b.v}0riJ7qHRcw+9`g8~hS(BE(bh}}/iLĸEsJq:ܬ[ t3&7^7h6 0x*a[su) 'F U v1Z??y&HiR^l=AVVYYzA"z$Tt:\x3gX5eO3ߐr,(%egɢW /--J=dKh]s l.$ 8ru:{8Lٓx<\Xw!'ޤ1Д!T!&G{U ,洤 u|t6f%F;@J =iJȑr v} Opk44dMW_3]457,ާFdi=@UI˜'Emm[ĉ}&ZV)ɝ)2Vdz@*g27GzڑvfK<ԞȌ}s-p&TL@@ f!8tx[0M(* +.}na߹s'Q/~ロ~?6M$+M:x}uFY&lX?fN4=ɖC}X-Q kQV8]xg2^PG}J fՀ0w|y8T\1;(К\?<A8gJJJ=Z[[ Bf{=o}ksžͥ^Jkk+?{jOz5*Җ-[ݷT7x}ѻ1G2իW\E-p}x g_:7E qN ׵rzY_v-m{M/hp"hi7A~__˙./4?K0k,֯_ܹsٱcw~w;w-Snv?4r硩O|xě׊q|c{~}< 7xc;W*>[-‘TO太*kIL>r X8{-I)HN4ԥcQ*aVZDQ۾˃O=Q:*ZF)%RHnTbVh@,FwhOqm9ATdU8δr%gRJ&Up 8zzo 71>q^@K UQӭ gNuv ~Sb*)BӜ1i$ al5(B=GagN+Im|hy#~D*B7{A7-2J;9DuŢU}Kaa!QTTDqq1NM\w> yHM;6AA^9yE!2.IDK D\p{Γi"ĉ\ pŲEk}oH-wXZ]jV-q#AZsdp9<"ds0!9{ih~O~6(-ĉb)B@;򲋩[p)OʨФiY_aMzLGvaͅǝMͬ|⦯Ͽ=tU%9}]%Ong֐v_蠬 /_iG,+w?'6<'}-1e[ũ7NݍMs[6vfX:0M沱ol>Ue (+0  u|U NG@kg]g'F9cx+rR`Ck-V?Aor@zi5!/^/a+'FE(DU!*ɨv0<>T?ROiNDW+Dmug,z)Eecw vEU5:{Fx6$|"$?G%߁?-ST]BA^)PyoPQ4/kq8\zSW r(-SA?-ih$ rv%)ч^{ R5jNҡDs)9F+~ׂ7ǠS]Vd<R3sNB{m=ۨZs^aM~z[(.*7|%/٦ٞ6mڔ4Vt\3`($ȠA4Xc7{r< gSW<(gp grksgQQQ9d&.{Td*;ﴢcr`L9ɀA4J#Q[]g*þ,*!*u Hc1{rM4Mt=X(pQ|>qK8Cn.,kjz$ vPbzp07d ثL ͅᢲyW!|>/y᭷Ưe K:#P] >,] kyۺNb"S0-/8@`DŽ3nV$OpuٺvMSuF4یۙ͌!|}"Ǯ^BS@( gߥoV hoM8bke4\JɾÿL,yH+UG㻶oĈc,듌i*vМ僿4u)"zy.֑@r!9I*D՜Vz] Kk/bK3Mub%RJ[A;qjn^ᓯOq<ذ;=epL}BC (®b9M| 6rx\ ֿ±8<[ JLJ f 3F 4y!I`'n|l۶-V1]L>_XUb~5K:8QQg$čIH)hcfՋE;oD]v_J4҇ıV.SE"GUamg&MkG'[Uz=r?8OÂ]GKީ:T&- )%#BCA>>d]vy_IXX%V6yjNE؛ia3ŊxN_/#'L#P$CxTCUTT՘n,du$u)R$FP#W[S;tYpj8z |%%Ff0 !XhkwJ`ul"9)|KA:thdIӘgB^^}~N-s2$19N3h#2d_믿6|nH^yay| K/c"PԠ(k Y Nb?ؽ{wO? K7-G/;0ԶJV@&BZ1GñS{,%7^,ENN>;FWq4 m M +9\BC( ^\.',(ʼU7dBY,J k;XYjUDQKkk7}k/N=ɑaǛz9ꐚ KfԽC>rs=-j2P`lTW, mGPBh!CJ;\J\vnˣ :@s**gNLPT .fs"+9,YrQDaX@( Kk.V4 ݈xEBFɓXIr*oi5UQu,5[զ nUhе){9~i.\8juiq3|]89bFmͥlǔ&Dץi:!:z(uR* scn}c -BIA%)k?|~^ 'Wq+i[VR$-Gwae4yI,L# z@©wQ1Mk3vjg1j}Gy; -?9Jn|~ZOXiLJoD- [FIpՆ" SG7„0=+sy|]Nnvf-lt ;ÅiZR-bD()4MjXlf#7gz4n!pcMuK5 }{כVd?hӰt=qBgޡb!(V=c>P(Q%p%$'v&NƑyW AM^m4 zXd-`O D"L >54|s5 BǑ$Snr6O,wdGt"ZMs`&Ra4>O#HocvݴO .DDta:ÉCs$(Ř4)I.(P\pwǎ ]G n7GÁѐ0gvf9L4H< cV YGb8t?"MQ_iפAE\2U"R&Ot^a$2/}biWޭtMa q;dݦ4wbER:ybi4N\TwMH;AGw#4& ?(,nk C|DՐJL)>&vB ^4iY,UlXyW^ǕWبYt=K O&U'\Lm4Z" ijR/ ]-}tϘ=DXNk#tl: `"fLixp,,y%fiB!?KMcl(vRfRvh ƭ*T%v{Bę,'|m`&=N^DaFvd5A$[ έZJQa1=7fi-[o9Ȇa,Kn3Vn$ZK @S\8Bd69UK)+IqE&Iӌ Iomiw geb;y孧ij;dEGyl젻FFi'TDIJ+DZagJW)D!D7"̧ [ax%  CI'{Re"2(;@J #lPu4R| TSDQ5V/NmZ۾SDg¼ Bau'sRҔӨ!5ԡYZcDSJffށ6 3eq $斣p34vߎN %bUʼn3VVQ^Dʩ !"5UTJ(N r瓓UǕcKR[]Cu 9՚4&%Zqbށv|~Aa+l ˄:b1Յa N۫JT;^A@5vX1QI~5ʧ?d{Bk>=˃p:2ZgBQjKrxȲHw효uWrmIP$TNۚLI +,w NFU4 }tLkQh{^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?CUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPn iUQDjZZQDj ֠TQ**?V#ZZ֢/k?TQTQ*TTEJEJԏԏGR?ԚFI֠OZEAGj OZ֟G֢/֠TQUZj#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB#WW Wf#Ovbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???ME$??)\@xDjDP@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9]8PNG  IHDRc IDATxw3{ JST`ǟhbPc%`K&F1E|MԨI4jPvqmD|Xnow>eo^|>‰Ӿ+iPGu^0cKchWxd9-e1|y(io8!L %c,Y5/1R ##@A "L~?ǃq rujybF4~i,xh˗L`7i q{\4GiJݍ@az`羍rYiD¿&S˧DY%;]MFH%gFwGs8X,N7hۋS+{`{leOTmawf<.>o=:#%% 8KZz):sBHK01 00 h4F uQO[Ktbz = 2 ;V.\#U6V.o'DCl j+HZlcfN8idhk"Ấky{=.Wc1bzPO8' 4n:| ]&M*'Ƀ& Et`6yzgu.MPrԲq-yڊK%&}L`/ZWQT˙}16n[cQ=ض;3Ϻۿja1gl(h1/ĩTn i UYgKH GWB!ʣcqޜ>]ZRPDսֆ9k%ay Db! Coh-b)`unZHl޾S]P~NJy8' dGa'`Q%j%Nz8ydU[iETUhiJvWm!mNjsȘ4fƌ"lM|?]Sޓ4iJy^aїimFQCTENq(?UQ VS<`}YF3Mua+7|v`51=J8vi ׆h,Laq&`Hө TQ/"Xeqx= ݈cGA" (J m2nG1p}qW4ՅpinEU4+PѨf쾀\`83h#GegQߖP{2hqŴ #F8?0HjyMaG"껅nؖ.9x<^TU0 Ծ4"Z5研2yN9,zt:Msqf_FsPkpko!E(*(]\}C«]5j&5ﴵ8_+(0EөC/4EM>>]zFxᰟ`H$@Ti{ DE=O`mtЛ{r_j !>7p`:`^tM⮬icgº{B4f7>[EQ4쯂bH.%=gކǕGM>nfQ`0PO,io>6XR)GcRwsWh9W: ѫ۠x UBwvhr(ynO#o?=jU)̺-;Vt]8$W9)~ }mQDf`ɒ%,Zn3;H˹}A$ XX,J4%؉Uy(RP'<}Kyca#yk;ۍ\lV}oуI&K/1rH}Q~[6850((TZO; WR{8$TTHKє `R#kn2;+|};gf{ .kOz%?O43w}~7_ ?XFk4 'xz:fjL %n\'f_#+w}38ùO6lRRWI:ӧOeZ 0w\˭J>} yǹw&= {|A(\z饬Kğzq'2m4><sG48C-Y&,`ĐiNFh`ѭ48?lɝ^//fviX>/NA ,X28q"og͚5 8AK.%//|0ZΝ SO=dzڡK*{ק=F)MF9iɽpԐ< }Z?K7n(ʼnb&45ޜ9sX|9PwaAIm~_F3f .Li /)SpW+PWWph"'"! Ӵc8Y1ZB0\ [M(t /0{lNuU&JΝ˰a,allnW~)O Ruݕi46a_4ClڑY=la 3)PH"W:|ac V(.,Ჳ~_|1[lb|'r4Nu]gzYi/QX8X7'nI$Pk"]$f 166!pql{#uiL}UF] 9ж ٕU=WHBC7q 78L(*. X'].2+|Atq w5o-Db.hA |o<yʙF&ZÇיفfx!ecdHiq^uRI0,kSuR`-VFsLoxB\//0RHH*k+!HWgs'OHfg6Ot$dW'hd[$~m E;N[u,2Z _^Enm85F?J3Uz'!7QZsC'U)n@ ҍB9UQc(mCǂh̾l1(5^Q%O<L*֦j%O"**W66x n֔dūEX4dūW͠AP{zkP 0QeCo9Nd˽ەR*26c( RUIn2vx= ˻˯~+~x)xz58kI@@߾0>hZ2nKZ'( n7gVb-Sʵ^7QA='Wx뭷[,F˲D6CFj@^<`sCDž6P%Y$$H%؞!p\6k7hצ3(*a`i5Y cׄ2+_7xyՇIIDAT2gvǝ^oY|gQO(\U_Rq2pB9)PH7jϓ Y/o6'Ov#={& `;毾JJqe9PUu*WXg2&,G<0)cъW6G8ٺv*9-|KM &u.N/! V|{6^#F`{6i).-|)Xe1hg8&~ϙ-yZ@&ӛ|}>zؽg;[wnf{dqQ]]-ZotؗvE? յvpv=)ԫW/ϗ4;Wi7|3}KuL1W/&Ln 32Av4D8 ;w.ś%K`prժxL㝍t6PrJs^-p؟&LIQ/rS0M4wur42e o>$+0inX_r6(Buu5\z) ﰾu{9q}Nstl׃<]_A{c>Ơ0츱Zk=:' Pg6tlxDCNVZ[u,7G}{˖-k6l|,UcO~$l e [n-,=?t~ 2s]<7/^`phN?y!Mm Ko] vSL]j(0ѵC5_|龶| >_H`u=Gցir%]3lt䱿I޶{` Gy&BTdBW<΋FyYfMMJh4?X͛%N ?Ms4RNT! Rk{qgbFaNzBY=UNGyZµ^KEEwݕ }'0z(,%x~\q6}>_!1=J0T}gͬ^/7n\:'ht]nO8n"CvL޼Bpc''@&xQOӧa}74mk~@bRiSEztG0Ƶ>n>3VZs rVXTlC@J1m:a&Ͼnkmi#uBQi {.N8 xM;߿w-ەҶS#AJv9묳شiyqLop-o/Km}m$9ꥥB{tJZ{XD\uUTVVRUU <LJGW0F͆@4(m?AQAo!03ϤGG?;$s/."^|y\kI;PďGp)l%~<zyKunjvrOl'TL\~I-UiRBYi9B o `P H4Ohȱ#zYýTE㫍-gu?dJ< &47BSUTECUx+5ڶ~~z*I'(*eغk}jgþln2*BMOLˇC.f =! [duczuY=>&Eqjn0Yq7 ɪ fq.XMJ'//i > KӞ,\IҚF 1C&խT [W:ˌ ES]-cOWѺEѣV 1Pt 0 Tc< ήͦOs!Z{Bʥb'JtOBxUts!`Ũ@յS`0 \PgX61bz4رwCN_+Ea/,i\wՆ񲎂 ts#`ӎ/QU liֆV:M4u\+Ͱ,xҡ\@nҎ([, IX'xij>+6tಳd&kb 3-ƭܷQUMK UM0ㅐk]JRV:)ӝF5pi C\{aKLX[|#k)(*TlI]8c_U@~Dn #9<.m_$ CPCh۲6GʒuQ;rn@_o,̩wQQ݈.٘ޑ~ƄI@.ūjܚ`/TvjF)G>t<\"Ycf}^$>'S\2N*w(bNka=FUT>]rrUUQUӴ6Bpډ 6,M!<}K˱IX)>{8Tϲ_4ǖ+ `i3Lc1f:GR!`YH@.VW,fPJ^ԙ2{TY*s!oC54KhKVV?rSS-IeSZϲi}#\kWR<`)Ϭ|{.[}a#~4 ZLc8 t!5֪"sE50s[\X+'=)J3߀f#fGs'T1}HR-y0c,zkQ)m(XruL37BPaK#w&4r8bGL( XzGvBnrge4D Wg˖q(IN܇ g K_9 q'y7T^jvY-iy4WRI5`oT@]@ ~tata&KWN3nqZd8{5֜E+i2"$5O4a:9^.[^)L3_^y*~6{_hOd!ok*I$y k,0cruo`؀ }+ɡPA ׏IJĤWZk%@# `:MmFi>#3!-}1$yތO`ɗ EQ9G6Cw~ao{ Ocr+7DSU\'9a{<;K-b+;MX:3Ǎ3oUemi=l޹i:%ωϤmQ'yĬb`cOB_;w@ÄSfR\XbEPHK)5;TPz)0&;W(MsB~+W)ytJ,Y\v"N?B 9l׏?-ql~q>?x-t%)LZ!5M^g#<G\AytջDR{ZwhK)s.vv>N}_6KDN,Vs´ R=|Ԍ[9qe'kNXvM pvXxcazT+3^@3}M"Ǹ51f`XU΅`MKz!LFP +Mf=Esz|IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTp iRRkTQ*UGHjZAEGj֤WTQT~muQDkOQDj*5Ij j (*U#TUQRE*ATQ/j#Z/֟E?(EGP_A֨?jGOZGEUP_GUDUD~muQDkOj#_ZiRZj ZZ/֪*ZZA '֚խ/j֨?QMj#j j ֨?jFQEF/(j*?Z֨5֨?ZiRZj (Z5(jAIZZ֪j I@$ $I@$ $$!! HBB$I H$I HHHH$I H$I H$I HHHHHHIHBB'#WmWpW!Wf#sUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???_W$??rh@dGW@?`ݛ?`ݛ?`ݛ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10m:PNG  IHDRc IDATxսwՙq{FFY#!$!$ $d6N {~6ko5a c`6@<9Ugz:MHuSw:9s? ȀcxJ(橿>0uWU6a؈F,MS&4} "lc9Ŋ"[4M#FKҖ'@wY:4ڗf3Zb09g_F#"[yEbQlzo%xdj[$ɣ6 I73 mF'4yZ}%'^m:>EF V4h)hB$2,Bڻ(VI, +&"XрXVdYAedd46c|t’gvV,^OOo'،m8Pdxۑh+X8v9W*xs3Xv@XhFuU"JrYAq*Gw<.7Ȟo3Z@=X,2XX^X0{U8=/ ^AN$X(ĸLh[t'$y-t8Ͼm̩wGjz}31&" /3dbcUlbCE$'_NC}3}2uIG,WG[ʔra YK݃U $@ӎ蓇ʿhB=ȳe-K(/ߢXW:jWt̼Y'%{!MCC㭝ϖ%Ya-(IVLtk4U߄vgK4#]sE$MW5}4McۮJas(cF'ڬiqBѴO(Z|  -ǻ9ӆ؎f 5ME{^:-N,j]$ scnRI`:LCUAK2.6c_w3q%O[Jj MP(q->i n'gsRM<74T@7Ξǣ)eCrɪ[Ũq݇G J+gQ(B?tB5וM$ 7nv ڸ$u$Kh$tYqIWv# {O]$)"UﭦjnWS9py q!O_Ub9g|<.X' nVyF>Bh{ av\}t q|xx8l.y|~e=A}C`/9TQo0 o )fp\g[= ӏG^s-6pd#];s x2屶iS6,R5H9ڽ6 ˀ9e`BQV.{uح.Gy`Kv&qOϦ"ǓLh Ɉj=1qB j z2o(c !>4`K4pZ\ɬXorZLqsKZtp< =U~rݰj\z鮢hooGT36n ͌%ikSM[2֍.}GbQPLŁbgz) Ŵp(Bw q{~M_;{toذKR[[˭ZT=GVC:{Dh$̂3}&qBtX<ݛ.?'K2Gx><" K*̀mp'%FQ]PN>qZ*^{D1uTèZͧ8?{gtwH:?3~pm=GL%Vʂ˙.Y KZ,ԃ+Æ\O9zGh?Pd /96 esݸ8>vZ8l ˀdi`x'կ~E[[MMMlu^D"#"8l.ӭWHR"EIl'pgjTvqڽ$)uA f]@{8e]򗿜Vh]^+jw9qF.\wQJlV'6mX 'y 75eAm`6.0=/ق45VPMZj{̝Myg_ٗFM6dRo'?Irw;iL@Y,:Λuc8@0]xTAfp!(7mݺhT{-/8ֽkꪫJC̽hr' &MD⑒ Sj#KqԊW&0xYBLf>B}ǎ?7͒ԓ B?q5FUE d96fu`8LuP i.Jp/1O4^} l]ϛQTW2z9ņ, [54~Rژ\j8ٰa?ٙ"ֽoN0ExW#x\%v˧aDCحPUјf.&ylv˴J\Xh,\g܄g`^F JV6 ݋ch+ZC(4MM|/Rs*svm(15CUB3(U{1uuu x}0:: h\﹣9#r;i|9WxR@FOh< >wИ (<V/9!Cl|ABfu02G,J#0dJjC(59ޱc_~9<6~٘ ȘyO[-veL &L^w!y/'Ȓ-$ Yur0 ƾߘĹJ]ǫ|}GnxظBȄ A/`<Bh:sƬ:%L5I>  㰹 G& w!zB`ǣ.~~_,yw.66=2 zr^5MXJDD%ySz^tBkZ ԨnATœis"A xGmpUuv1T5NM9z#8ޥ1].A@r#جSHe6Nȴ]vUafBB2 !c k..ݵ1>HEFq3@[<*=iBz4YVLe3ʤ8}ŵA,-4q,dtnSdtHt0(xtRӟ^LJFLRh)ԪX(BE2wsې#GVfUSS+~16AY`_V_ľ}<+w0͝ I ./c:8ֳ8R`'v<xyW55ڤo ;78;cn=xxpdf lQe9=Wꁄjc2 nմ߷h7gZ /)bVj.g>qT>wM\?1+8NHK(2ɖt\djY8g q-ƈQX>kv>ɏzzo9zt^5S)-lٲOaw㰹Ye1"<:yԸN5ƈţ׿`I]OhYy547^%!r@TbjP5eBl\coHE.?X݁[nC0#\k?>nwa[o%'JP<#d :yFqYs^W جbQZ~6vhӷL_~B+Lb }/m U ; Ν+jb[o;vSx"*ْx \\rg`NRe:il21|˗Ͷ}0^w@x],Np9|;t":/,٬NqUo$ȳfɅg}&^'5.s"֯_onoo|l+v7nҥK?8;G9>蔟RzYǝoPD1Ou`k讬DMM2SeS+9ϬyА!X-_r%=˿;MK/tϣxPxxO{KΝw ):,a:~OyA|Ĺ V^-q5}-v1ɫ%+| *UWĜeeTmժU+) 7ܐ|_^p=sW߶_ō7*>&Vܼʬm|)6{DUE .; ns$UI\yĚ%TynuU-]̮_"f.(ۅoذ!g_z濉#YM'>#~8cQlbѷlr3k֬)Vp;W'+DPK V8%IJ:>|08Sceۮp;h*P peM`tԐy-2}ݠKf-[ux\y.p2c4"4=b3ūGrO&  1b<a%twu=ӛO0 HSXt;MPdCdzݛ-kUa袋D[>4bZfŋz,$I,\mgRSy/󕯜ns&™b8r)bsJ6uo&::;Bf7O=5ݹΎF73A~bYA1(4'Sk[kcVxkJFU)< vV/k拺`lj?뮻޿"IɃ$ |e#NCA|y,v;?7EDa$3kd Ýii%Ͷ擋:F{*y]wq} l[b_MM xM;#mf."?vxƘeC0IAݟI\B=FFP),INhV+3~#?)'!Rn:?NL^}$qbI"hz6<" Wc(((9E)](:=߰S,ɐpSMɓG"Ds1﷟$dTTTu\M~wedIF7A)PT_t_ueSzv<}`Z5f3D(ȥ%ڴ/~q^y>qM`669#I=J$IBU㌗@Xfţn `yyYQS#GŖ|l! t?!I w44eΜ9DQnW^Ӆ,뛜68c>#v6*zh1jƔDXN8LK2۞_d]"!J??b۶}OévZ>ϥ/5L% TGL. qOt&Mf-EVh*iur]8%6=Ejo}8c[[w񡼏Ou)>= MϨ Y^w aO9S-@ھ[V3f^ϱPѹYtͨrq=HDi}ѬVSO=믿Ξ={k}<9B7"jB^WN ~&BԴؚӰԔХQbJ26:>ۙ:; wP=O_`E։wz7n䪫O}*Ix,+?=gHT:֭MH芧XKOv:,n=ر/[*␉y<-1x2 i)ħMj@s O=?|VWrmJ4!{$2݋b5vdY&GS$ifTSHx| }K%kfug۴mX-6lVWɈ0f<(c!FCtg0]&qF{ +z?adYfӊ ${[b1v;{_.YRdO1Dz~~wrYgMEţ9唼Ì+}X.͢FDCy'ӆKm.3/Y) K s"7y*j]/8#3|@ʾXi|s|>wͧ>֕ ÑPH7+,jY `-" ,)Eo{ho;sRb I0b"rgp YiiXfΰA.1q>Oկ~5mp!ȧisF#Gs^U3uZhxՎuUtxUIS԰%I%IRl[gSesK24 $ga7ִ~4-^ANZ7$Y_NyyH]4QQ2v;GT%Fb\ˡ2~i~? f;w%Ky]gie̪]@\1e.lgƟ[ݤ8&\(–⌓?$6iuU J<*Y)AiX*Z٭NuRTA$qY^=Y3!n'v~_\\EBc{ضmXBd:{QٲļYIM_"[Zlj^aBc@LBX-v$tDkUWoswK7=!t60*$INq we+* r T*_=9lNw*}جN$Iw3MË`hW_19y&6wދs':NYZtD]}?['? (43CHWV2 t#QuUsذ{xtȒ 10af({]5 y15Cnظ }Bs[ʔ.2_7e^ښW"'DQ6HHfi jᒳnG Mh552UMŢXt{OUహʒ/!aHH$+*wQ1M}w]v1@s^Ġöa`_Ss"CZ0%4BG뫭3-Uxkʒ_> ! ٕ5EN'#G6c+Kw㺛4.@ ߛ𹃦"N 4ִQM]u n<)Ip:tL_,vJ82J\MMVZbQlX֮%s0'V,ֶ_`ѷFo\n)*AStv4Kp$'Ecckڨ Ρin_>ݼT! Nce d%Pg_Z$帠ǔľr6$Tِ$M7| ;@$2jڨje[桳4T$VdYg]'[SW&WFq G Ibp+N Gli3mb}@>O͍-H|=_X-v6˂'bٹm-悳>ߟĎޙ#%|"vavE I&;iZQ8 Ęn`81JsLj*8dY7_fS>Oţج!4Ec"Uxk飾ٳqm u6'lA1(<&̦zR|2$7slik5d>R!C+<.}Y'l$--Mٍ̟ )xN)|`y*gvxiF$(*%w{BF"IL'I8p]AnH(ówNIbo^z.:Y[ 88quzy8YkşUxk*ˀIV*p}hM5.,L/Hu^B$Ii!/>LDdi Åœy\u^(Τi rp9|(Sqhjq{O5K/D$ypGJRo*Z Gszm H< `tz:ϼ9ˈEQ:ْ/u:P5*fdAmYďŜWj GB)Ky1;wzDwhM*}̘IJEUe#V#m"E6zy) !iKRY,vOZ(L.qKz]*5޼B AAN5mx]ȢkLW.:C$2-ٻo£'.T;$: S mU6)bjyx LYd[xzl]U ۻm(HhnjDC>V.ڈ,I!4 I=2&1 Im+ @2gRk,)ϗ\/_Wǣ&ĶY){u?.5WcAK{ccnLVJ-. uU-8l., Yq;+8ҵKW7%ue\dc,GvEpS(%ilV' B@ M+Y[ cⰺq]\q3SϾb(bQSS RCL`\o5?"[AxMGqs"V->GjX(¾ɞb9n3oҍUʫnfC@mp~OXdtaj%=ڴ!V_H<}#ps4]H3eI1\{ergcwTKڂ9%2QrA a5xx$/Bp\X3K<w"Xk U41n!V.TCUe#U,N~p%LզSJjVS<`Rk;bijY§asq&N"[tqLWB[ÞovG^΄᮴\d8ر]sg16>#YzGB8Ia}qzŌ`LM{;Ždѷ_4$8)ItwÝ;6c}yILDžv@F6cxut;G>T8L}gxBhh!+'XрEW6<sA;-pu bW_[$uo:vp㽂 c'=ԱĶT8yVq-x~/$?DbS=EkY2w=b3<&;V]w揜TJb9x]^k#3M~;4!;2O(2jJ?\&4_IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?y J*UGj֨?QR?*UEJEJ֨?P_QQZTT(QQTGUmuQDkOQDj*5Ij j (Z5(jAT$TIZATQAT֠(iQDj*?Zj EUW/֨?RG֠֨?(Z Z֨:"#/k?j#ZTQjTkMjPZ'GAQUԟ'Tj I?֭iUWERkTQP_EGP_ER5j*5iQDkQQ֟E?ETkMjP_QD#IQDkTj OFUP_H$I H$I$!! HBB $I@$ $IBBB@$ $I@$ $I@$ $IBBBBBBHBB$!?#WfW #$Ivbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??`?XO``V@? -? -? -??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 110(PNG  IHDRc IDATxw[}?cp8UMU$UhQMȊ[+%:Y9+q|9I,]EIfmmYb[JJۢ(ɔ;CrfXaサ`8CfPfx=ý?_+ £zQUQuT&^)<7wE^r鮠(HHȒ$IHLVO}a$$^?$-WEs<BȲbGB޲4>o!L<IY{ݽ̝~;6g@d %W PdȔ 5q>%<BHHLP I$ EVi >-H:(Y}a #xP΃^^"H#2 I=v~WWZAM4ԶӂxT{OF+璸nԄv/!LLa K2B0B` >6ADB7&ߞh'A L!LJ$I^v`H_<AKlBze~xȡ*5$u,cP0O?xnؾ̼'@sLgӂ;O y.E A$Zsr4 LS0u #,ɘf2-m $<&LJ,)Ȳ${ChhPaQdj \3gU!}E\5&:BZTՋ|xj5,`Ry7#y\O4g;]5{%&fPiiW3*Fנ^Ya7-֨ 6 |lC}G{ 54Ϥ.2/z+-"-}<y(@]-K.27Hc4k,2~-?]tk4M(dYELD7.+)"F$@>ʹ+qvғg3p`)3 EL)!oJ.Ӥ'vk> 7I\m.CrV.YKUęs=|kRXيHT^ {wkn% nfɂ% ɓ}yN,B2'щoDvIC,dK7˂<}} /[ W[hxO+#T1a fsm{-Y;^ I]% ea|GctuGP] OetueT[!jw 7+!{gT%hoa6پ8^ۊihbWIj\V ĺD;v0wk;L&{.?ey6nHr7uwq- JW}8." 1oҜ-!r[yX,;{>*I5~,>r:ehX+G}6) fLR{<2Qxa jbr=zg^|QDcDc;wۙ7pgaep[;b{<?>{`9G!^"zd4d˖-e+HO=f^~{,F 8~zm{;P-nXMJ< |!9G桇iv]vɵ^ˣ>Z6Ν; AHK,H@ֱ\(8I$,X_8)y-w>Ioogrkׯ_ڵkǏg|_.}O<? <0P&FC{8ѹpW JIȲIJIM^k"9ukqΝ;&K/Č3x _x0Gaɒ%ek4u# ًomDKzyhʿnTU)8yꩧ*&,$I>O|b ?Yx9z)Μ9׾8=i]@X+vfV$B˃:ulyտ" 57K+)&<oζm׿^~~r!/r]wJxͰ޲S.8OPN{~ 6o~ei7[nz{ڵG)n`Of\\I~ >YEX讒1L ,AG}rrȱiq>i6mnj@.쐝-g"gMe0fSu)݇T73oI_?Ǯ$v.B"!0 t].҂,) MOF9{ ܖng\?yQ6y`d]o1/h#Gpyy ifPY0iW30]3߃*y4BF$*eɦH+Vpҏ SN;m7L*|[boP0B:\r|Qvұ{(b嗹 &"X!)_qrnqs[\Hhd:F&&Ih4N+ŠÊaTJrK@)Lxbpz/C}2zZI yiΤdruҞh';LE}ޖ=,?s[CD1ӻG~FhgiEmM**mW 5lٙ M ^l y>Rk#c0KFOYt#"{7aӺ!adIҙLd^SiD;im -.P+ yn_AtS'Ic۹j]ͣ^TUs٦i?iaf1,7p}!?U&,yn_}a #K:]bx<^4%뮾 7HVϒͦy{KN(H<<I`f+%(A> w'$y> =K&\ߩqA8XoGe$IA&WY 1I67FNQ7B:<$ˤqg .Kѹwɓ_@<=jBپ|xt`KH50~o/!I2L^kQU YVf &zK&wdyzgh 2 WeB?EC*)md9s"o9zܹnLo/& [Z"苠**lnxٮ3QQiy~kn*H9d0Y{ݽ40=Ŏ,xz7Ii Ba>_t&I2ॷ "xT/`Xqg¢y: 1 ؕ' y6{M `o>{|_?.y5/0PPt:I2g冴/bU1VtKJ9xް&D :g{NT[$:,~0A_XJyyF"aTY#D3 T2T CJۊ2 &K7" "ܱA~o m_v=&5sVN!NՇ +'0 ~ %i4͒3A͏_ ~mh k"ta քƁwfΪ!E5׻XAWim D^-@sL{1covٽw, $a%C=gn/}Ed+ճWhlX94u^?ג5wIx[Yieؚ޽`oa>B~Q3Y+P]pwhėTAlN3Ga=ۻ^,,I!=R9LjCq3]lXy?OFپ_Ycb:&Z!I~b|B.ټ>?UY@ o,K"G7~mGL6ɩ3' [l臨u.%%o#[(y8$ %v}_ muгtuL ڵ+F_GjRLwr5@PKm+~_ e'y|d ~s=re™iC΃y:ϭJlu}r&K>J +>"M뙢& <E^-B 򃃯7V!5HSelQ52$L3=2Y:K U\lO;E=35X뮿H,Yl $Y)IR={|PUB]ȕnZVp%%ś,'(I$'8[Tf͛GX* p8ӎS>!pR$ +o.y%igb&&L'vCUU |BMM8kj'Tz!L+ y7!IDPKLs{d}[\GXTDjD:F4=L/| E' 3\<YNۇo` 3y[UW2e0G"%iW2!H$Bg<^x2H&*Y:z8ncNy\wm%oL+s/#E8U\ȉ|In&,X3,^ວ~{JR^UML { l(&ϴy^o%0 4667mٳY|9W]uSLo_br_0aL1$Vi\2P,Hv鳇,DWb/)~}t~;S4Mɝ̝\μj̶iњgjӼ*0&.B~SwҪ 7U[qn:[ Z LZ!w""AscnzZ7D2CU4XPѝOhNzt!8ѱ7Z8܂72Fq94rLLjSQRzz`,MNZn H{ &z k\l iUؒ84AS}5v#۫k[il^Ht$=L$p#B.бӻ.V< [g|Z@UTb~ީr JA$ҙ$$]0yVW!z*ܪyqb;m q Ye;?(eW? `gϱi~\]p,f$ CY14'#ëPd;qTxWGn=[,52|FOC9u?J2g%i6\]Vy5I[M;EK?^M) p΂0Cs({Ds,4U  6EP7V W=h%rc kr {ཽ/_ u\HOsmاE<e ދ&,(*-ki 96>70M넣q0DOޖ4Ϛ_` @^ı7t=Kmr:!`0C"9g;i_ +o⾻+,];>VNυg`+dѼJx<ϱSq'Q~͓x/~_N/sluwk#SzDBuȲJK_: ImsGa L+*3GZ!N. )VFT:N20u,o&:؃$Ì)WuLw]]3s|078jIDATY0ršYo]2Qqi'gHebIL(n #$æuMvNtwÂJK&:pnm`g<]HgqLarquw5n݀`v뢒q!vk,;[eiT N_ZNj=@҃q`Yz]`N\,%:ce(SwDvq*L٭/Jqs/]rYUcFV$TR,#ɣ*}2{l3M aned7qk_59HfѕuK'wK30@.s2m;¸y5I5ڲ0V:sIY ShJ!$:`S_/kGNPt顋@.y a-۔"O,@iynO!4PӨ|LL O_g6 q.yj.2-R`0@ԩ 7h QL`#PE'"pkƔYnلG*J^,H/B LDTŃFeZr%ib 7e9̹wH$Amz+y2,OĖ9gɡ52FEQQ4ԴR7Nv}d4- hq>"o7QցJ.[He#>2d2I@L$Ӥf*Ѯ1˕&% HCS]5u&ETI0{"NT٥1Mk+:xw3nZ2#I 2PJmt6I,G<9@VOsm2vƂ}c)黰jU'O~+XcFsDϻqHt",#I25:;b>ҙ$^_t @C}=m3UsQU 4b`~w+Ԡ]$"3LDjwBhA`e77L`q% &zMpb~_)IIo(PWT;N}H: LXlZ9Zڗ &@.֦Ö c<Dj!dBnFnDEe #N.'<B9 A:psiGU!2K@ya[ ]Oɦэ lcA{o&Mu3X8khQed?umCw(#r<ƂL6ad1rҤ )V-Lz;Y8ƲRUH=FXZWBdlF;PNk`:N腙.r2/S}IWϑeŝ;Hc.nB[٦$XVv~s23:Q*fEW/sG8w9dތ 4r </^͇dR躞دž6t|y #oI>N[lrTu]H*ȶ1SjXߑ\pJ_i7e/ecp-U#N$IIٴ0- 唐xFmOo^2{ HxT 2Ð#\*$IA$hs`0W>&&_M`J'Hg$q(i;՜ijhE>^OUzo_Ok<V_'a;V\`<(y"֓L[Hx5?Ibda㼒KXPwW{HHI2lsēēQ9#D!ԡi>~o.xf!8CvNp`<$ɫ)8u~oUQ2_u[ƌ=>rʡcz9?$IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUk iUQDjZZQDj ֢֠kR?(j*>*T֟E?EJTkMjQHHP_QD#IQDkTj ZATQAT֠(iQDj*?Zj EUW/֨?RG֠֨?(Z Z֨:"#/k?j#ZTQjTkMjPZ'GAQUԟ'Tj I?֭iUWERkTQP_EGP_ER5j*5iQDkQQ֟E?ETkMjP_QD#IQDkTj OFUP_H$I H$I$!! HBB $I@$ $IBBB@$ $I@$ $I@$ $IBBBBBBHBB$!?#W Wf#vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???ƾ$??v6@hIV@?@}?@}?@}??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12#PNG  IHDRc IDATxw\y)۫ՕPA HX2`!L㗗Ćmb &`bHlǯ%lSD`!uV^{-3;fVjg=s33<9Od ӧC^xNUܛj 銣G ݝtcHW46BssI3uun{sI3ǎ5 cspsc3ǀy 4\oLAK ƌcHc!i1!i1!i1!i1!i񾭜BEzx<i4MC4ZE̓Y<n>0f# @8'+#!n;&Z(܅ϛAvf>ui3y,Z8cJM9W(5%y3PbIcI(g?£ u`[`-Up'I iYbDQTº45LŃ!uѯ= $5uCnLwaT3GU<1_^EAJ 17t\7F6cy| @bH21*R2J¨d0d!91JĘI-F%H(xTS3z1*f1Q)y@0`T2 jV-]\*[Acۮ`TJM #|-G4IytC3=VW50AGхQU' ǐYJID ,qRNX "䇻L3qC2U@ќ9a3i Okj1Δ7 `dg!ӟ3Ԟ~PPP@VVchƁ[V.V/#@sSYYIyy9?p׬YhF8t@  sL hKe8v[tM|'ίk׿7vΝy97#}PM"h/S\*iJ:tfz)f̘%K(--% 6NL /p+x7f "A&MqҊm5$MzܻHe\r=/wH ry /^XG>NpdȜY2BN%')o9\~co ]#Iٚ|{Vw%3Z"8=k,\Ppl kBUc9.UDNVAPѫٮݧGs[7 ֭[NJ+)Mx TvJatoPM6v-_*a.NFy))/Ab8 :2DHu7*7n$??f܌DR7]\Bswи S=pu;FI")F"ihK2! _XN}s+Wɓv_TC"o(I$u G]bQlٲ.+@jNuEg`8 ` tC044=ira%g+-+M L8I㦻zq^|^THiDJ;-H)oT'IWeY`V?S?}LE%`.ݕ@֭[YbEܹ3AkG(EQ=H&gfYh!&}JIe^NX]ZkJ pNxĞ@ ދ]*8ze4 I\+IL4 Ta?fy`'?qO70fkswΡ*P ԁڻ c o26KVд;T aI0$N͍=#8ݥ?Ҕ"qŲrA .>+֓y|ތhOtZj7ޟ8m2 +L]2B;3N0wPeH¨1r{wM$ h_( P;=' FK˴ZzD0PU|ҬVUFn0 =vMnIrhUQQUHND\ ^GU :8\Փy29! `so`$ uVe ETcUJ]?ٖgΜUW]7ߜx0qD7/ܤbНyfO]y/нGD(|\Ƭn *<~B 0a-DNfZk}[RUT)AMӜL+Vzj> ڼydgg߲kfX}ǻɑ]tZ(.(%3#BQԘ+LjZ8SdfE´u6qr`.*`ꛫӹӒ%sqW؄WH#Gp!v3<͛;x'iooM~?zv+ѯ&j;R]3 4=fIL}ž#8DtDz<E`S087Do9{6Ovv6[nև&$cm$X23FCUT"xt'+3QNgCT2fP]K8\-##gx l<D ~[j8PQ hYJ_"Ox|3r-*=%9ꏣ:W}&fDsOs~':(D@eeeC!7!ZZL?Ճ>ȟ^FIgi'ZcK-H8TQ̚uz y<^|݊c)nS$\ ,Aoȑ#VNtb΂|\̖na͚5l߾y?9SMhlE"9T:#,J]CU>4-k(J|aP{}q;s Wo60ڶgyk_я~DvvK(--w;ロ͛?;48_rxQi%,c(hȌĐ sa-HD _߉nX< Ӯ}W.~!y9֭[ls6mr;=uٲ -5!T'VyFB.RJcIYp$H8u.[I|ElϛjqY0; 6mb޽̝;wHt{4448뭷sI~~l,[FaDd|aPc(;5Z9|̼+;x˾".St&7t Zg_}5j'' +Q裏-5zakWi).$!ilLց +FD rEfȕv 2$< dm%=m\$@?s\}Ճ@(tƍsmb .B~&+/j Ju@S $\u8kyN0o/o%"ӟ+ҋyL1C[jG͛7s^~e^{5z衞g\Ös5´dg0,eu&R9p3uӦM< t=ű(;S^HRdžibno[֮]KWC, 冉?#;4V']΄}R 6~__|̉2G4ܺw!w.('`Ӣ*T˼[+_wGw|nmH)!{e [^j+ҮU~xJ'TXx۞7;^\AAe^3;!@e5 W-{C[n1_jN܇ټLJSxxQ%s?=lt[xi -5f0t‘p-إkSSDtwUcFLQP8`TQx3[RPb<抢˯LiIS{3pm;w&Ξ1uCi0+fID-zlҬd0Xtt,lt#B(}7@,[bĈ0d+O 8~b]De3]er`8- [ei}hz!X.hB)GDa{3i ѧn@RgՒ0DͿwh53\g $× ;yͤ=\3 8p<~D$8kڹ#qc~JGmܶaG!pfHxkoRǐ]fG0t]-X47R8G(Hcb ;L4)%K(Lony->pE^,]8IhHu-{_%3#M ~OoM~XL_6&;F4UKW}||n 4]O8^ ;AW1_sד) :ٲ_cauƠںbؙ0L*^T3,=ah,u*1lcy{H Tb1w\%&ϛAWL*"/ .#;3,rjZ2/nܰ iUX-C7t'O^ R">Vx`r2Ksk=uGBh;^ 7ر۵ Cl,Om+y tl*_vZ>ܳiI;\;}n)d|?(Ԟ<Ʊ=|ˮ"V[7w7itpq 3 M X}$E;Ӻu BaaE8UEMa=(PA?jlkuc ipz3O}S ˝; pysMNq >)vUQ|iLE+ /ȧ zű5cajO%N>͈+v%x˵;"qeTLYT,4o~0ۘYȬm yos>~Z0e\23т4@SK=MlK(1y wlZɜŵ5JZȹncoGC+@pE0p {vZiiY!:m7')4}D&MIP4 WP bE(X|#ARXv#MR+Ow=֯g6˒foP3lq"ZPtJ#].Mf9Dfy\A)^4Mc[%#:|0w?&L+Ϛ d):5V!k쐬Xg1n B15=RVЬ=Q\P02OqA)K^4a~|~HC88)ry_0tvڂϛI/ UFV)GB$o1n1G̶֘SM= m= F4,E4HWPʂ+{02 zQ=@&fFBPըhvIZOK݉WH.6 r;cTy3iu;Kaޤg0hM>Ɩ`jj0,\8_Q0w8hiwkwds -،]Q71=RoZjF10btsUFϓauSe^QԔ~Ӊ܆S0K8Cc%@v2=`KCgyK:1BN0U1gҪqZ>,҆yGG8Ȱv.Gr:cW$SRH{vSv;Ud/딈<)mH_XFلٖ1h]0{aiۭslÝ"W~;ZXe9oZIl߿Yt#fD<S QP]lErlu>6^1sUdã=OIX||O̙~>1d>gqEa!Jbzh J'rLlvkmJi)ybMN0IDAT{O<[+kp@"ڎS^t;RsPEQe930xɚ֒`G"])wB9Hz2+UKCeI`{}GҚy.> r'"zzq(#b}y܊%j!pB@S[]Rs-\rލND3„#A*rf'8uR1KJŽsfARG_Q̄&ĊP<٘|9d.+ r'BB]TrNĈ^GL$K-^'r勜Y 5icD~N1p`5'hL!I[:e@n_h*\S&͍!na֔2nYTco2Z1e+o&;@jNHP_4 ;,#0]vT7QѝQY҆y._lvZ9u#5\Eug"9m"f+$wy3.4*Rg~\xT@; 0AZ3Z.}zì)K[A*9TFQdA!{3ࣽ37@ Њ'ܖ<=.u8~½WMfƖZf$0̳j:@ejz$Χ%HBsmy3W q'2M4!EC[]v;uA^8<%07/^ӖbV8JgK,Ag-y 0t'5x%*{CUۇ4w_0.mO0Y P'H ~Y"FQwjQzVkGUzZpi0Y lJ./)|0n8fey/Nd/İ6oe{|?0,fIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?g?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@p i*_QD*Z(TT֫Z(AT֭jGEEGP_ZFG֢ZkT֠ZZ֠ZGZZ֩?_IUZ*UGj#Z/֟E?(EGP_A֨?jGOZGEUP_GUDUD~muQDkOj#_ZiRZj ZZ/֪*ZZA '֚խ/j֨?QMj#j j ֨?jFQEF/(j*?Z֨5֨?ZiRZj (Z5(jAIZZ֪j I@$ $I@$ $$!! HBB$I H$I HHHH$I H$I H$I HHHHHHIHBB'#W!W#sꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??@5>N@Ga5`fT@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 130 PNG  IHDRcIDATxytյUգԚGke$[زl@ i%/$Kr3@^a]Lrx00Cl06-[dy<ٚ%Y,ɪO:u){+枇KsđErB& lڱau͘Cأ9!)b>=5$ŧl/fFMW/;چJMnF3YLb|n;E1CtE_bR3cR&.j;N͝m5CA7BC2R %Sx;_p[5PUweBU5EAQTQQP0fYbRe,Q,^<:TES~dExA7t[UCAX> àr;*Q8a2ELr )"%Bjb۹kQyqB踴 }PUw< 1W A@ĢXɚQR$v(PU_a¬@梾xW?7J;݅a4π 5 C_D@ "E0tRэ'ksMu*Ѿw{&y\#m6$""35=uMB0A0"$ħ#T.̓4I"Ucڔ<yFF0B jMtBzI0ԉ'ƥQURɜg\B$Zc&Mպ يЍ $y|FفM1Q!(#LJ;=m` >z\>ѾQUAxj ^S!(XΛ|DWGf>Ǚm2'|  z*}6DuQkK03*B=N58Qw;-4h,;g<"< ot}^{=8A@L-sH36iAAenk 2f;GyM7`OÒWm@8HM*yJKk~8lK YK .$2PDylSȾc `ᬫ%KaΘg!ޟL+IOcrLȀ4eMٿXv4M0[6"mu3FK !.yL-EK{݊i7=oX1Ek{ "B:4UCUM?5V."d|¥|:6QC1udˮXz vV ; V uqJoY5`>5ʜnҰ8 ϛ~5 ija_g]<=0 I ~ "sC#FC Jˬ( SJlGNsrw135/F!G)E(boV@8'o*5گ0hDv wBZ;Z8Vi܌yq)y_ީFRHO%-),(44 ysmwoSsf ob Ÿ:O3qAx )(4cLJ/,,ͩk=>"[BD(̝~ACpU6TZ3]1K$%1UQ9QwNs1*BUπ=xRpm:۶39k+1"m]|޵#Ro]NvZy`:0>o<)yWy* Axݧ.Q6r3Q7v(AHAx> %WY: P-X䎨oKQo7|X1iƓ:u9Q5G%%qh>yUx|rm,s9. m4.;#3ur$DH[&JҜsrpܧ,+`migTVlԩ;oǐkfZ$jk~jʙ~`l!>+Lu7 z>S.$9 رc=PPhVIV;:[mHaJ0}:!%%cryb1B3XpD*U;d>vko)rŚTWP]_q[tPf-Dq2ĉƖ-0gN2g+.=Rx2)?P KC_3VkpUW_wXox/Suv-aZ wޡ<$<`o[i(Jí2w{!|۠*o~%%nsY[^T.NryZ媫&_->" ZLϗիW˕W^)O7zku~eHs뭷UVVy6"YiS$+@I_~sinƋߗ $}#u<9ߵ+χІ3gڟkv\[b_Zˀi@пyh/+q`jlذ_u\s5qƾA~w-+V@G0ɥylz}8R﷈wCɺ]r:[z!YzG#4E]^qi1T*--_|>pW_}p|}Zaje#GWTh6LJ֭+W ={O;9mF;i+F t lBii)eee8qAkk+,Z3f | v]{=.TDUry3ۺ{عsgL^xsW}3V+Q _Ɩ $L CU5<.omYDP\\̂ Xw,ŧ?i6m\2~,q!nDcO=tğѓٔTEUդ g\v9F{CSSw4777h C|ƞ={1b۩CaBzٵ\.6l`=M >hj{( [A>Ckmt())AgK/ώ34ӦFŸ5׸Bz]䙉X7ڋX0>o߾}}'e=ag)B> hzumk׮aitb50tӕ勤 ~?1%T~Ce@UG-"[ZzB<~H߱-ihfF"[syp ,k4믿Eii)]t%%%5f|ޟN@XLO#-Ғ+m✵9߃tx`䟽f.\Hvv6,^._ْ64$'d.ɔ@CK%+,2ƪU Ν&t_HLM֭ zxxK1-Z0r[L=OW̛吖&yß౰w^8q %_ώ1`ɜ&.y\.#(*'~#tN?$OUEUmV))Kgׯg?gy^;INDgjlD`Mg}c >.t=崬 6~QjQH deő<"xh֭[ӟOO <0㰵5@L4%shhAC[{ m-΀yANjbΉڃ!BZR )@| M;^T}y&<̟q9~oD!g"A@:!#Dk[3oߓә!AVZ[A Ng>A0{2Ʉ -lpV H !NS7gu:gڋJG#4ׯg38 >CfZ>¥yp=x>OYB]ąEЬ¥~#y&&g~oo'i:Yc_wkpTuO}jQUūcs3q k4}(jXjX*Lpd"jθf-C7BNHl]ǁ̴)6()\j/qTWt8iI95  y y y y V纩IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPr iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj HTQ(iQD**R*R*U**TTj#֪P_QDZAQDTQPA_QDu]TETGP_ZF֨?֚'/֠O(Zj?OZmiZ֪j#UZ֨?֠Z֠j#֤kUTkZ֢/k?j#Zj#֚'/֠ZGZZ֩?_Tj֠$ $I@$ $IHBB$!!!! H$I H$I H$I!!!!!! H$I H$$!! HB#W W#$vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???]U$??C@@@ ;V@?۳?۳?۳??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14u'PNG  IHDRc IDATxy}?z]ҌFHb ̾8H{upl$1/q'8Ƈg;f5zf7@Hhiު}Tuuh{ꔺU{ppq; @_\/ڛgJr}JǮ[)L+܉hBG[XRGN? #( Iro'ofs hB#W/-;ExicaTާgι.(@JYfwmΫ&GMC>Vf;?rBL3C29F49i_r% ɠr7Vh:ARXV~!X܃鈂Á5 aYΛ~2Y,5ɯ]0aoe=dk\|.7hFqrIcHc,c&N'M{h[wɻ&B)u{|=CX rI V-96L2fDjvWJ*&PpC+&hA\Ö m]%u9)%'ݾY'-$Vz,qJkl"˜ܮe,5z,h4фFGK7xs Eu< `f=A*S$չ$M^䂏]G:ĴL[u'" 7ĥ'ˮ+멞X&4G+n)(4x[y)R)rYq>+]q pGldX,F,#qD_N/{ΎX$c&8+@+ىߛOvgz}da@Q7Wolٹ2(%T3Wc0eaY1@M(~pZ,|g+'-²L,&躁a;PՓ*p']lh2J >t݃{;ZXS/?֑i[}U6izhB.`<ʃŞ|J)]/+ DPce NG7 (,̓<&~0 CIc_o~]3\ $ܶpp̶}}?Ï ~.Xw=| \ 1m.^!42f: {,ۥp+9+kTVDeٟ%gf|"}35M  x}!v-BKoL%'hA=!xg˪ÐYAVs  U98cP=XZgMIJ'-DW{d`,:;G"}!N9"2fWt&,=LJ& ܉>RBV8` @ܻfJ/ձ0fKFl"l%n!sqLyceK'ҙNC[%afhƭ+ocQ4э?>ry$R#DmM}!V-=TrфV.B Ptv,kHeFȘWS5\Mcj)-MDBDm t6z[CkS'xO<]-9 FzBʬgAVSgd49p/C12:5W]O߄&4RQKY:c#C97`$h/F'vʲ O # u%OnZb/Ǘ[[Gl+ h2@t?g4WsI\[#ײ̊waΓmF[͡tÃ&tޚbTzcZQX-ß׈"2k] Ç l%h" c^LWsF>Fk,֎ʮ[o1<,t&V-*G1ekiˁRզ ?t&I& 9s:A[N( VL y -҅ihƖw~B`M]vB-$^WE,>@$PJHGm zax"Jlt*=y ]74CpsTTcA㬷AֱƵզq9DsxBRDp#\h!VNP'd! fXD` komV[~oiPeX؏E#bäTG) Boh}C{:.D ^|*o%d:. so}u0':dޟd-0IQ!ZuK87baj 7Y:$HGEOR;Kd)T?[y;DD$Ԇzj{M:'GoN!hv?u.c'UAt юhA46xңuo<`0{X,pUӷY8&= GUeZ}CIj∐< O ,)1a)'="]wv*Hb*F`ړg5g0DNk Iם$"aX#Qפ9D{3*maijOWH:c-݄_gwCVG5@y*Ŵ,[pÇ(tpo&PSO=Mіr!|27g, E"RcZgu,_x I: 0 m.wet:g>"M`27@3fӻJ[v.#jE)v$LE1Ç{p,{zjjعs';vO56:0t3\zX 1Fs#H NCh aΤȘI55eJ&'`KG\/9ÓOCb N=T/^w}B@L:ߜ[oeʕl\^|4;3XtM'J9ڨ;y}N/q%ML6SNέuP(ڍ\Xr%ׯo~nxFR<>+2F o_ݾO=hwӍ8PY2 qF: fN`DǢ7AX^×\X|9^P( ^ 7:Ѝ7S(yxZJk\08vtTnVZ[ ,<mɳsFL)czNQO-yYa0eY}Bׄ%`wEZr}=3K x}>Rzk fVo/ɦY(i);|>EY1t I6RG/-^"Ceiv+^ NyM+7n)E)65Dc}SCDizVx"J(Ќ%!yo#uz׶XLIEsVa{:KbN$mBh|%K|/[M>;%>b0yu+M2X(% k z!p]wձ0hFm?Yʰw) ;)l.;E_O slܸ.?H1!yV@`ZiFiL ꫯ/|) 㒧s)B2fd*ސ3Fwb!~nT5c(Lwֆq#g &`0<]VGHgf

t3"u }3&҉wcYfX{zk턦SHsvGuLØ;O;;HT!3k 2\)~_aCed_ 2bZ564FJ hV8^ihB)A#M*;.ɳpªEEkiv` kk'N&tZRr堒\;۹+8@{|aU8تZ"3U{l5}XZZRt]w*m\e˖;<ӟw}U]szZg f .5mXzf-Usf-.C֭+̋tSӄ|SRO=TY}^5k֨K.7!!!'a4#I6(׵z+sGz9묳馛عsgIO)%Q>Q?D* (tL3vs/t^{&cF{%ipp+dشKUFNd!8i3ieX}|IuD"rॗS*cwwwe6o7 ڧm%ZY5 62:H: cBca E{GRl|I˸u쬬4BԜё>?RZ)]K,^x!OtwsΫq|>_e\;+@P5DfS]f,:cl6lP>{EgVkRQӀJIwd I'?_z՜ͫsAJ۶Uوi>@M;lG[S'H }gpWi&~e;O!Ke]Ư$m[ VtWF&"ĥTR+}L-r=3 ?<]vre^~=~_ﳟ:_^sqCN5%'O3,ibI 2FB*ɞmhC<1{{+ p2p*O}2w9Sɗ{PySyr-Aoo/?KhYoaؿ _O5@Yz@B##4$((GD-~Av@L&ٶmwQ})1c5 9>BUD9$1L =/w;_r{C(Tt&H}Cرgyz{?> t{SJ&۞36LoN.= YB̌J'3߰\ g/~ѐ'š?Ni:$,&04 -aC隁iFɘ)FFdۮka(ⳟ,?ڏ+J"h oh/n~4nn])%CCO$aFI*Ǻ{:Υ WOt_^=lףGYGJ|[}`z^9syQJ_}ۯGQ=YT*03 ׾^=_ c\Zr'B'Sp׾\Wٳ`_?{ndz+<}عwy'_jΖv60q(*5v$JJ?i0aE^RYk-WkeQJdÄșY@v`K+)ٹh,[mt. h&j'l# 1;3Zfԕ@Pl"ۜ*9ǡ >LT۹   yx=8x4:%z](菖xhBǒ&UaO?(J3k_HH` sn?{۵kQhmD:x7Zn;:t(YI8k9[ Zh<<uxd @VJs Ay]A04h ='ebwFm";D^ Ãie0tmMZr )@b{ d&o{n4Mvng;Gvѝ@#Ez ;EP)UQް*&υ+u.Ea#{vۗ&7] יMiΤPnqTDk.A w`7On)M7DBmhB/1:BFZ" (]6ƫ[[˾6q|0JIeOձ@ aEEO}a;{_}w?T5"8 ×cP0cJ\zg~`p}z&hC&:m$eOB_,IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@m iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZT(TQ֠j jmuQDkOj#QQJIT(ZAEj֪?EQDAEuQQA[]iTQZW֢ZkT֠Z֩?֨?j ֤֩?jP_IkKZ(TjZZj*?Z(ZTkQQKj#Z֠(i(֢ZkT֠Zj#֩jMj#ZP_R֪֟5Z@$ $I@$ $I! HBBI H$I H$I H$I H$I HB$!! #WWfWm#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??@H@IL9AS@? ̰? ̰? ̰??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15>PNG  IHDRc IDATxwՕݓH3fFqF9 D6`8iwYfy]`560AP< 3#MΝ ='(}ZS]us=HE_Mn¨wGN` csK6?٧Ɉ{OQ\\ v͇ۍvzG|tahH} hqdInW"򳋺ܷrWM2GK"p<~300 6lolQFU]ܼ^qܸ,n\<]vܧcV| c#IRkzp$ahg 1- C87JuO_KqZ9l2a Cq܅Ku#K Vzzi餦JJJj\PIK0tZ}>vl ENL2_`O # P7aF^N؁!t C<x-}:N7t .˶" pVvN6Y9dgY^ϯj"̺C>_m${q< kA5)g*Ol2fHKF$$IF`Z+05! B!4Mí&ao q!udEEM# w3-77%'ahx65Y t4֧Y6Vݠia"cKټEz[H-t~sٜ GBm>mmʲ,|;‘$(*lv6yCG$ɎV)"| @)S[i)Y:7ц`hHkI3l2"=7ia4-np$Ȥ #I.SBB[lS,}#L(uJ(.a0a].$Il9MqDꛫm܇U{<֞wLAu*ƒIXı_7ۏj]薏+д@ 6uOb3X4=Bv_-ı.~q, * PT0ER Gs0(fhH19Y_d/E׭{uNfuX:&4-ę0j6gS\S-D@nN\n4=ׄo7]Ù *TŅ$) 0.CD 8Z~GR_WG]}F""dYfpctVS:fgh5~E3PĖT~m&9Z^ItﭏO~^>xp\fb#ll=y&sDBx-5W84;W [4[$y#Tgj}M25mwﭫ~qgeat+0Ɲ:Kq#I2wPSPHq\Yum>w{lcqeH$L,lw!Zڈ¶ [:..7$iyb.*cny\]v_om{z1#(*Bv۠kL[Pd$Ȳ̞{mBG\#}(vY loUW;|8TU'*yn[/ƆO fŒtzGJR:nc̛rb,tcS~<qO6_#H ;ăYL^յ:l[6ˮZkm'nKەL QuUu#K2a-8&%ry㼹Ȳ,e7s`+\v#m+|BW7\QvGq# k$ȩ=>啻 ,+jb byV,)C<#v Fb\,sIZTLĴKHrid%+k6o`9F)ÞiY}s-ghjHA( 0,,ÇcDBhBas6Ns׵?玺L'8 7yl'ԡ[il3T97Y݅-蚆,s#r3 xR:e_&'ITN[gl @"cZ(*`iKL)YDD iOVP^x}n/7׼~ÀLPZlưd%wRR8}OzcSVbcbP;ڹI[u^)سwdY5cp3ΚtQ C' ~G: ð!+`4oumk+B^ZN1eoAQ]]!LUeD N՝4Za^`XidδFJJr]/X;l2=Ղf-Zbitc ۷$vc[Bt1!/-HvF';;Nt2CvgA(͐kay›`iHa d1hOu55CL5kRoYcm.ø8zjgg?`jDZ9‘G ꆆk=:Z➻Cau @Uhz8&AE)RN~Ow>J&1%`D$z] d89`xdV|Yfdx$&K2$ѾK{_WV^MI"$7LkDt!*z#@u7锤 /k.ՃRYsɷ2_HHJ X4F‘ n&.Q/DXx v_#dQ\ɐkV] y"HO͡&k CcɏHЎStLސ \7D-DVo=ŅдCsFr6}ʹyhikE4m"59çqn=lHI\,I;J<oI9N>!c{=Lwle?>!N :R4t`[U@k9 O ]̉Wry$UP$w}*>3Uo0qc2e@9e伎h!4=L~*k8kL[+dvm'=FA0Lwvz/SWk-z8Zayc$OXJX/կ 86eHN1=;}RJFL'ٓ1ח͹\  ;6TbЂq+jB|A/M2),`AQ\/˗3B !6]@ B>g[QDRґ$L:Ž*I`zm73Z?ݶ{#TM' 'ʖ-[ޓw6Q]`ȋk4eFj.I3B^pŅGI; &pK%v_#&!@+¼n_ɔepti i5Ydf5M')t$.d{EAXڨWkxNvo }|~P'N?_ЍP;`[\|7Yg@,\4c=0uzIqđ$Cˉ0z`}m̘ . 7\-|6[N=&]dD)*DDqQtx6".;H]X;(q.c5.o UGs$>,;c(nwMD n-a{1#56_`n`eL^DgQ5M 7 ZM]oy(n'ӆ]&#{T]U= ~Zkn8N}S%vaUV(p]RQUUUPY4 ``(h - -)\6y5k[\vU-L08 e)#a !IϬի1cl>/#hAUw3[`kB~^>˾$I"j;МrK!P%_EBhHz 1tiua:XY˭>7Ғ*DO}eso!HFٜqdddƺwS>P]|Me0 Z l,MoU1%E#lC8j0N'bjN2oJ%FWϸpL;+W|ObHNl+Yʋz!-zҒM7O<| ;@)-xvrJfMrR|j6َ-CE!.1}"?~!EwYٗ~)q dydхީ2@s{=ogC|?2@ ݞ{(YL77/pby 6|?uGi֣nGpzyU8gS8[4THjrvMj lqlCqj7';Vc*@ $i~upA^0s%I$F+eI޳?0^3&Lnu}9)9TB̸a@'?|,CuصYu*y5xъ[JBjIDATl۷'s~f]W_.7ϽFMcdq {D>BPt !U1 ,_'SEuq>̺qĎ4`qo7]x/ dddSS/ֽY<g]\6f|fX 3~ls`?™7)S:q JbYVHMp^ ]ԷTq`G vŊV>PE0֗:eN4=7ԷfX^x3ξI!Iӷ{ ]O)S~}`9˒S}m }(4s3͂*T0e6hnie$E=Y:`@創R,0"+Gy.+tTf5tߌ! ϸ -%j⭖S?5v-SyK1U$YVodؐ7Wv ¦`޴JL +ˠ5[HMYxĉ~ x$ddI LhA2R{Bvn afBǓձMMpJ,,c٢"@Hd$ITŅ$4"K{JG06^z{c~vm<YX6 rxIp߮ c? Nj ole ٚGhlcޔ:K8-0uh]II9QæV=;XQ744=BD т#tݴGNjE^ yeuXuhvZy,XGOkLOE:ZID%Q4j2.;`@m 8.x@p-[W~CƢ9#gIMNLCzeNSfQųpzU EXtQ}>)xY1w9u۷A7YV+{FmCw32%K#gĈl=DWXM}nӥ G/>cfH$a']{`բڍ?}3;ъ8l2eıV8!(J~ CC$+ԪI%?!8} dv0I||m2SPU`;s-e)c !@Va03Jђ71r s:m*s fv>Bo]QKE<|%۶mf$`;0 4|8KNDԩS9\<.y]2Y|96lwml @7⭚ǕLD[v6 =^DBD*9Vvw#8<K*$1r&EvZ!=_^qǿD󲆣rG~TKK|Jtؾ`^OӇPx!D\5g*\ڦS\6f]g.XQEVyNmΛz)0qR|cq@LgiJ7z/)~ΔUg 7dO:38AHDSk5K迷'le^ccj{'@NFH78JVk6%I{^8hC#yWF hK&MWZ)S}4f^ %gruah (R󊭩u{J *n묞#2'@ "m'v(T3q F3v $N>{F7Ţr%Ee )vwfB#VMZJ6iYxx)ܼ~+WJd.:}>]dOɋ:88xH'\4tP߻(AvPL*OTV=a\DT*XS[A sOxH(oklL=i]I,2džji:6? /ҙkx+NJ NZHOVgqnU4=#) P14qKt,j0t.{om{OL-O䒅ZmyIKV 7<}흭·cf`[a=K/ouo\uGsH+ctM9%h9lcIݾ^YYftAwEd},Z-fS^p@BDѯ]{+.fO ʢkMP3&,c+.`mA)lf=?I7̪{ -i?rsf}Rx?rżwZ;n*]΢k% v}ڦ.y]@Fj^Laǎ=%|'L55jy0s;Vj‘ pP$NibҚo\-p_>yH,*6/(aܱ~NdbŨ=q]xA"} &~6n믿Ό3Xv-ڇMuYB81Hm=m ~˦yzy+9q )'EU],;) #kABy0%h};e;c{Dcg3)YcǁJ9˞s)/\64XK1BsF zr`l|RΞ3mN)#}W3g76xϞAڏ~[a}2ыY:& jul-xB+O8 6ٖIMΠhwdy`֔F׮><3qbq!EE&5W|Dq?,ʸBz _h:k$I<)} Q58^ KftY-&ϡfAȳXş[Z/84l2v~ۮ.W g7k| hl9#;/!|m\ [zŅSf;bBa?ofSi~϶>1UYS9~z'88!N^K3LEA^:b-PO;yz@Vn^y?0n[үQk?$2$Yr|"e1~y( w1ftBSy0_hUfؐƩ$SlPpIuK8yDdz R^ Uuqݲo<6_B !KɶAQO,pA Y)֒(JvP\|7< EzJ6a˞W|zgڈ6*=&2%ܬBN^in;y+G`:8Sc$qO|RIʨaS8RYXJ(d9 7ܠ?rNy\I⽝|' v=fRSSowu.-tC#=%'_9~eM=Ē+9 Uu><e'MEed󞿒=c@pQ?_:ٱJˮG`-kRS[˶#7kYUi¼#?$w  I֩O-y K+#$I4"YGU#qe7o5}"z}^,AZj6*?'c/ 7{^eehz,|u!c0Uqc:OS~"G\KV-DJr) RII$59LR)/!=%Z}aU<=7fʚC:H8QIF+no_.?C;^@U\t1iwuz0:v1dSs}aٵxdl=|nWcŧjjsn@⣃oZ V,#KS(6Qoç;Pߦ5 ǩm<߶ABKz !yS?΄s(+ ]7M&|-OGl2ضi,;yI N aXE=IENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUq iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj R*QR*S֨5Ej QQ/j#֪P_QDTRR?EQDAEuQQA[]iTQZW֢ZkT֠Z֩?֨?j ֤֩?jP_IkKZ(TjZZj*?Z(ZTkQQKj#Z֠(i(֢ZkT֠Zj#֩jMj#ZP_R֪֟5Z@$ $I@$ $I! HBBI H$I H$I H$I H$I HB$!! #WfWW #xUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???um$??MBD@EXyW@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16&PNG  IHDRc IDATxyU{on KU +pp>gqy__Q'eQ`26$$d׾Ty8U}}~I:uWys9T8jZ ¤R z:EE$TS`Y&e`YebhnRLQRRXhhTWQ_@*e088S` @ 0iLr$楮q3oPYsQ0SfX?#$8H"T1HޞzǸEõQl8t^YF$T"e$'GF\LMU#ibY&]u?;50ē$ |Nk\j[뻟(/Fq,i!E<9Rk+%y,'"Q75O ?ԅi%ik. 40$EGqoi\H8XEuvZ[bL>Ė&$%e2*U#y淮 $HI2'oHi>@}M ibI.v5!qFFh,iDQjkhGG۪Jf2KxUEEgA1JH )%(ĐMJ~ׯ,&WPnt5山 ݄Q8Ҳ!Rá%fy xc41DakqڏSmD:oLoּn49464"Xaf*J<[W D^U"9J,1D@ꝱ"jB*Hi)87P'o3y)U:ZB2m0.Քe#i(3L@]14`ɛOt&BSDRӻsJ’4 F# ρΝ_keThnjorˍ'W%I$ceBGJ~ީW V]!2]bZjD"- SXaXfx2F<9B<1{+U4ֵSe5U tww/9ʁ94 e_I LĴRgd)]QR*;c4Hb$1tY Cwg`/D(9ʅJ%Q$S 8#b9kT$0RXa$ޑC%$w\R*"Y&zmF9 !jij'&jS24EQJ1KPM\|GF*a&1$e22EY̛QWLMU>-@LKd͖O14H$G&qXvzQL3a0-]L>rwi?_]Qb$im#EӢʵ"9JwI>R $)3ivZj G8fHOQRfM`Цޥp@P#'gO{,>hrĒrGӞk2h RF6JN82԰p̸䩯i  ع&w͊sQmM@ENa7GL۪:{!0!/g\8yB$:wMߪd4>LL`η\8tEN ە#5k՞%OKQBlR!K tMjbJАEK{`i{BS<,i!Јd!0a,ibC z隮`WT"4ya/F}#3O=LJŕ6tVIii…m:i#3BV{@p`;yg$E  i:bL Py 4]yƯ&m,5HU~FUG♌80njH)7òq( J Zqc#E!qKNS"Jxs:ܳ!ݧM+ϕBz=_9G+?%iI.٬\()'baY&M a@]ӼwSZsH BXt%pcf:)~20erȓ2eMP,L<ƧPw^=\ P0 Zۼv}nɽ f E OvdXIeZvl5.qNđs̢/%cv h jc:ʢ:5I) ȉ<+s{9ǴW"BP񠉒 償v?9g“qQH:d\xdLPۦBnvHäQQ8ZL@ ˕[h1!y/<}T鞢3yu1 LAVH0` <y+<#zmz:A7UnjT-+2hzw蚮0 W|g)VM_ʏ.jЅ>ʁopMфRDQmO5^5-|}bfOHLI S,y:RBv/$, i:CȷBZ" 2_MhJrkG$T5M}PQ3oT ĒgyM?D(XE8%" D >T*ίB"lhwp㱟T"yj! r'?'JX88jn%p}:SUU.y˕LHƍ4(⤡# u7t]8ԽNbCDõ\vuy?ǿj'u;EL"~ICmkStūFtP d4>a$28 |M2S?1(X TUZt}5p5 5״V8[oڴkFUֱ.ۨcpFzBz[.WUXϲHc8>ã޽ 2 ~ʒO9x4鿕uDž,`olyM+$8KP'dP §?I'ؾ}s;A#O/N պqȎvR2pW7b͖\Rgx{ߋoܔoWwT~.fb):VO~Rxfgp3e$<߄F7p# Y&2Jbu_}2_aTim۶mSN.;ؒ%z }Ї>QRH>f/Abq244O<9眣~$N]73sGz'/2}j)P!˫=Í7wܡMKPŀxYNwk-b튇jM]OO>b}lB]@I:,VZ'g>:wn@;p ]q+X$M?ld#]¤C$ãӿYE<ٶ~zNρ?$vl˞ȉ_ot'|桇t+e+)HZE9.Vˁt-r6s|7^Zۿ7pWfs]wó>w駟\U,.iHM?Qm${aBRNveݺu$ ^|G 7U"`0g?_xgYn}ӦM԰k.nV|I[uV ^V^R)Fjk s47%I 400@89%HƳTpZ2vy].Byu_/m&7m$7nܘqg}|%  Ns<\.ƺ] kZeC2K.'xB-'nZҨBsAgg's 6|rel;ӟĎj~ʕ|S3t馛Xj7A*> Q[݈3o@gcg+\v-ZgyJ d(X%ChIСm_'//}I>S=4q[@v !6A6Դ64UK eeڒ 2dSB<Nxu>;2/~Whc>gHUVqmWrUՄI~:B!xx9ɭloYCoo ¡M 31)qG[[P[[?y_W|mNb ?VV\ώmSLҤwBߞ؃]Vzu3y<0R \k?O9s渤{ <9.;Ζ:1q]AMK2!OȌʻe&q}[! ^BL'x]ohhpaZs2n9= 9"㏻&|gi]_nV?;d4(u`͖O!8'tGAVm4G!,iY6l  gw?Ri$i+^@KOS' u>c~CqI'04-[뮻n袋<+_}>)u$Z"9 @s_zb1 xbwH$c/udMuڒP *Z)og,_ ܵkWэ7ʭ[O;4SOo{nƶ7q\кBvlkZ,[MzOrÆ ecC)<]v=Ò%K/~K~;]w<O?4guv~:7nOG?^={;LML9uhٗӺ&+x^WQ2};S;q}3+ktl޼o p>[0M^{K/6.>D4@:68|>Ls4_"s;CdW!qΜ?)p ,X c/q׎ ";btK`'Љ0r"R!'Q]םhH\'?X@ESV7XݕӲar*ӋO~L&ٽ{7[lj5~%۸b6.Q|ARr{^5, xj^LB`II<#qIBl~N+U 6p%u,K$ni}UAކT"ɠˑfGx1;'kE"Ch>FzXwG;|;:TtwqDŽQa:=*3S4I>eQ Ji$dd*{.ą%K$/b3s4.,y+Gg}lYS0s>4t8 oNoo$.Tr-gw34,xH*p1HT܋?{}}}A"p]Bwfƍi'FMDCuwC#r \0œ:[%**-u]OڸGtK֑봃X B_w34ݍ<`(<kW*S=$ ۛә:N}f NLm1QL0Adqe'me[i_:J5(}6qe6.*a=*9 35S^ ?ѭZp)a`ˮpaȓ95z$d$Vphu(sN#){#Ӱ󤛔KolqgI4i'rҝ=]n"P<*5J ;ѸNjٙ߶o]C[R9#Z=õKy Rѽ*5r<ʌc!2@LI.U fsmsQ.3{X|vwy#Wdyb0M}&!gÕ4jIm,ok:q,|,QSI٣q4wؗ;- pT+9Ӱ xz%:.890=3;.'ߦyeg1!̅ 3E20RT!Hdn7^,;DvԘs Xw(>|gq$4]zǝJmt-VNKNE|>@|yXChйrE^I(1k:)tWtSJށ\ȓ~3^pBE[^vB_}o(zXRiO<+z'{#  ,դ @}jv?]GtԘG Nٍ%ϒyլu/ص%,?NF c?(RuI&%?swg uۤXTıTXeYt]GV<k?șݧ;Ϩ8 9ghB4Mb{mMHJ~XB%Vvᔮ+'k|JZUYRMiYh])y.SkNDMh!uJ=9["s"HfPSYv,>=`KBj%e˱$i͗iSu ]WΑI2]UyMhЀ%=%IJLLW<ԯm7ށ“NU"ryu42(풩^3Xa-w Hgg+m1+f}/x =r1-;OGn6-?hnzn&dnJ I2EJ*B9ΌdϾ;=今,ȫ>gkpƺ8]iKeKeQLmn,”eUqjܩ0)tݗwt yb&O!7%@nd9XRK_D1vfWǫ G/ToYz|;LmMx%Ac];_]Nc~ y;;F[؀\sؚ Ͷ/#N(̫D 8T\R1&1܈abDw:^= 26=JL{`ν_2fy#5֪(3nh!8"u$ a9hπ/bI]+˝(Hp>}yf3cuOP44K_*oO\HFgJH"N"5J<0h ֖zesSIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUl iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj OZ֟G*U*j T֠TQUZj#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB#WWf#vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???D<$??@?@@3 \sR@?P6?P6?P6??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17[%PNG  IHDRc IDATxyutp  "*@H6Ѹq#j_6/fxl֨k5*!r)Ü=}Vn澘^UT=ߪs|nST|]h(%Lv_.Z#@'_k/Jfoz}xt/Y|鄂A,aQU{])RB_i:b !3F׽?Pu=IPď$zEZ4GERRU[Fqŧ` n:ؖM?|4M4fDjÆ:ĩ yBl/z4GzBEUT,wE61o Gc#=Z_*! } <q}bC"Ϭɋ1@-ŲH)(ń3q:v+gx}D"%pϷ<&/&Ų +e( H EAHmfGU45TƇ#I*yNx.BXˢ!X0̨M(ia4UCQUBO{0$4E1TϾm=Z@@[< !,UH,a!yGTUGJ&Q3-l.{TUE lN5PЄ<Æ!Z (1ٝ)G=:s=!Lm/y5YCTcc2&"7k(B:hB#6d BX(IGtPT)Ad*e7/ÄC!>r,a ѼL-UE(a?wcFN$R[MC%Y4kLnKH+Zt<GhKvN@"9mBEi;%#-EQ GBѽ*h6aBɩL3q_2Ӗ\ڲWBJ꥔d04&9Vv Ƅ1$w[rҘR*׃At_BHpP(D(4MqRF ͛;J}o!# 5BC Cu6jOfzyم蚇Iҽ&Jگ?!-q8yyGO(Fcgk 6C񰉄ÍK\6ǃ!=ܱeYI XVa(n 7, hQ%xlTcQF#5=h/sk]x= gHp2>q@A:DB3M)nU3Bdb UQPEU2Rc]ڭ8`Οw7稳?hkQP]1DXm9Gkz|Ls:0> RJCuD!#W/w~GJ9g8c^OZ&IA!'sR~3pcϾ9tIϋ1F$iE1-3>j㊧3  9Rs`^I`؏az5눘aBFL`dQϻ}Qp`p$@m}=L SkW5xt9w(3=)0 [ n sՍ)wb!͛A~ΰ-;cbidbZK0'6P{mQhsWaZo;h=e1e1BD0#n}5uw}ѽ`)a1-&֛*8!i y9(/ASu rGP;*7!qs,0#44Vs~l|dOcC^V>o:oaFDD&D ]1M-eGRj 5aHH_'/QEP}2r00 TC8Ҙ,aRp5A"e8.KHJg5xz|\C Ҟ^3c[(+A0'͛ʅrU :m%jG(?}1hB wK&XI**j@Hf2dÆAS==6,azz мQRHADn7/"$ݗ# qwca)Q:r ,=tM@@ApLaKXm{Lt_&.PEe>,ܣ2544V]ԣuP=9H4T),5LjDC( RnXc ]" Zi}<3L#^iC u2++#H)0(f'`kbA9ZQt_V/v(*e wlA} EHaܤb!#-EH^}ĝH4?&Ҽ(D0Joь9Xv7n73 Nymh<NxȄ }RJt"zomYfqb͚5z\'8p{WAF@?{ W'Jn'|B8fɒ%w}pWv~<_ X6fX' >B1߾};ӦMsS(ݖr_ęQ|])sޕ0uT=\|A.BV^_{w},]}QIDcN&3ٰ8t&۷sg/lgӟW\[la֭|̛7G+P_,4l}Es&ӧ3w\GxfO]k뮃\g]ec*BU͑&pBޯ OC3_φ 8|؎֭u]N &Xsa-u(_¤Ҽ_:8ad)l{wۮuGwx7Ypa2 pKa!U)}%wkF,K7q΍Z$9f:\K/n:YQkV:rJ [/KRQOYVYqy1 ȝ;w{L^C^Wc̙՟hd3#5K~-'Op)9C,uM>>SN=TFGc5eFgl޼CUat.駟GEkPV56S5m(e%3mO)y'Z61fT{j-)J͛ip5IHŒe)))~%L7pSGlƶ}&34@Tm}-`d7 4k"N29Ĭ?+H)Ws~o%-6M?GH;=E.t܄>Lۼ+s @j :>R|vco)Hh&6jDRJaCƠ*:h ",[w-@QȪeiB @1#{ۺqd1ロ/6Ƥol.4ٰaguV_P$iw0u*c oUΨQ0z4L'tEݍ'Ѥ131SQMFGcL5&cvĴF!idq{Kئlc {6l< -bLvPkz= .b8|xyhh?nll 1haoQ#d` bXW$2'j:qNe%3xs JAub1%e\mW=ǣESOi/_΅^ȼyU-!AWuwU9||l۶uֹǛ<΄h)ONCu:4,y_qwGh>˕ ynu)OM6qeR3UЂ"C%q i{M7~/^̣dG݃'iw}xt;K~ͤYdfdQ]WsYx#6iuf̘W\JEE'R)0b>&3ǥGr Æ n_űCWfG(q_'Gq-[pwc%m$Hi~2>o!bXzj4TEcTM;^wI쮊 '(!`%-++;ϒHzUh,[S1TRKk=$7Ͻ$D!E4>yy8&ϛheEe󮸢_d„ ɭ` *Rڴ aǾxm8˖-cݺu<8~_`Yji7_[ ۰,;Qnv1M2yzݿvZaZQ3B X7H@? jkk:%L9%{`EhnR6C|=AN H*Yq?)AJqg `B{_[<'-IAFZV+5y[.,fA%`ʠYtIVN6?s,a?s+bб.?)RSo$™3u)8C~-&,DDQTW{S|qf/i|]#R*{$$6TEurN00vٓ3}˞l67Щ(s-u0lǞ6{B}\K+M/:beH¶l8A.9i\1SXsȠMrEw*6A {6}8UIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@n iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEA*QZ֨5Ej /GEJ*OP_*#'Tj j#Zժ /j#*?Z֨5E֯EF֩?ARQDUWIRG֠kMj֗UTQZ&ETTQ#Z֢_֗FA[]iTQTQEF֩?AGR?ԚFI֠Z?TkUW$I H$I HB$!! @$ $I@$ $$$$I@$ $I @$ $I@$ $$$$$$$$!! HBB#WtWfW #D?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@vbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???ώ$??=zK@"#@`P@?@{?@{?@{??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 18'PNG  IHDRc IDATxwxս?gfvWղ"lセ1\ib077 !$!{xo{op!$\.  0 w nɖ,ɲzݙs?쮴yvg̙39+PtC -%Bե޹q#f7+D7!@|yh%}MȬ<&Ơ<i=_CQp(y_ Wqv㬢Gj/ѲF]L߬!&%xF??wF R{kBPJ 4ZQRҩ Ui:# WRmtK,4MGE;ni&e73YCx_c-y:`摒NMJ@i:-abʮL=]?jvwK#59C#4CT֔6}Q:/1>YCRDJTRZHeۿjw'HOB ҊwY aiSK!$-ӒVݫ< F^h@T;*{ RI.~C KZYRH%, $JYH%J\Lu.ɓ@$}aYVwY a(lƭ6iu_|W2QJy#w)WPJu+  h͉p.mŵ%"JtDհ<>MyYg#'vP|奘.ǻwO&yn+AHi:zaGN| WDBޘG9ݕ>R()(u'ap#FeuIEwP.yB MD!).t&ꭠwn eIoY=J<'qյ mʙ< @[t'1pm=I:7q]vbZ>ڵg";-ysRJ4MC4wMXn]Е,d aPSSCII 'Odǎݻ00*04]7Bo$f؄2|hCcΧn Є44 /@lx~jὦ逆@9.ʶ4U i!Y7y^KEEEEEۿ[J8{~e K^]#t?ak>O"x^8 /sA 1b_\ {B^ #PryU1z CI&%wc:pWct==J6{@PU[V9/y*#MH84`-J)Oc'6:$TJqB0TMM"J)tʛ"l e5 iU躏'hQ},’cٴw`T>rOBmu4HɃ"=%C גWt3jh>oJE[C;YTE&O #G P29#΂-'+cfʄR 4*Vmu0ȨpncY&Gխkd5$1h""d k: j0Rn\gBpܠu(Ƕ]m ѣB? ƹFG'ğ2uBp0Xie~zVd]Kח,-H0ft9$O]ʜI@q-ꫯf]8Z.Cf$$k0MH9`ӁPg#Obȋ V UQ"l=-@8z$n`hnexnB|uxc#9y<1.Rz)x m1bq(1UU Bp\y#xz'pxduK=^ҝJ ;f @' O4\"daZa__iG4oI7ų>=@}ŔW]jK.olHdڍQ>%O}QPJi̚x%h>47ZD9O(6V},X@RRRys֙v|q7)ct^c]>6TR;D:Ihos ï_zz:˖5wr4GOv> W ʞ'^E)e3nuDK aԋq糫}سȹm[ץNVD_dͦxoQ%ozm_AzT֭$m~x{DO~YjUy3/l ћs!!Y6m";w٠s~ҥ_VDG_{mmuV[g7nGy={PUU? wB΍bڵkKRRbϘv@8'ɳpBL¾}ky% b(\ž 1cyyytM+ m ,XЦ͝;W\2ؼyԓO>>쳄?o;m o@."Oz-Z^zꄷ-N=U袋{[ R[{^C{.j8*EgE-gdok=P>ԩS_O%_Wl}f(&X=1ߪE5zm9gduZtY^N/y\m7￟9svZﵸԅ5J%:ylٲ-[0|?6hoL&h.DCQuv\2mavrq>ٰE<4GtvL5K)*B]}k[*yT#zΎ`RZ =,]<]K2k[Tg`а,Ӗ:( H%)5~[T>_Xsh"^|+ _q4ftB  I^v<]Yy \nYp!m۶vB߬l'۱pax͞$G_$K%>ٳҧPm mb}zNYNfF_N[泍=H^>ހg>y̙Cvv6<f͊[.yfyqj.Þiԧ yæIa 6~?4?sZrϮ9橋דc=s=LyqǔC|$/&N(\sMoW 0‭H='$O]\e˖quwBZv>O2hQS= Mq|vy3 W J)xEq3uTzK_%%2ВiGeH o{ݟ%˜Mvdh)3XqW)$i̞=˗D,u\Ma1뤥~wCo% 0P(a3vlZNZwS3$|V'91i B=qG-b̕qKNJq &􈵀Cz=_ͲN Ne;ɓx,DSK%n.OA*EUmy>h"i)}`ǾPZQfۑJ{rPә:a.$l [t D`˱iڋ z~u&;P'v,Gb@&ώ}km7ܴǠJm"op7(7b6vp1/&c@ݱn~2v(C<~]k;s;W7Ŕk6y.q JZ2̺mŜr=NdFH =ͽiɏ0e2y[;@a3O(49Uo!=y=ot>[@x0O\0nOuKRp-Q^Lkf5ma؅(Ew~_2ɯw PvNF24*y'tM=RT˩ 1u?z>=3kW ϱfoUlD9ot>gb,[7ySm[_{cDũ.N ]9k[Ur{$OΆ])*3uBJ #- 9)'_~ :w;J)fO:B1:;{6 j*~ߵK݈ZdîزASγ56НuF;y3o5N௪e0|@JkOJJ /ϑ=()9 @~R#q|@kKpKZԆڲIm7'D_.quԔ6yހ/ŎPqMYcP  l6){rϿlh y3]{m uOS`]`P\JJ"O%)nʀSbUG]U*|\\8+ EgRQHfꆊbWAlRR 3"=n" KYcr4~d@vC'MS /f?!]tWՕ4 Hw30mI3R2% c~hzߢӹ9ǐJ+cJO |.((p$"lj f(Ċ!O54 ' 0q<4M(&3 U{c`'seHe"pȣ0t>Ϙ19鋷7@7EOMpq.nvDL;C;:m{kKO:);ؿB8N.q ;ur}glFDOqٌC΢!$_6jCUΗc[1R5ޠLHA ylt݇ϰgL~\wYݳfͪ FW5/ZhX^FwgS((w,Oq Kكhȸc_iտR _{Ǥ籓_q4K*OSY]J0TB#y_r4|Rr,Y3RUQZQHiE!% -&ʛz-dsC㙃iqȎ'v'/=lf C c1'mSu$Ksb'ؿD .J (.Cte (*9Fq F g0vL"+QR^|K8Uz\l.I3g03IRqc fڢ:\#~]ӐBZ })붿+ع? JInʎ:͛ڹ74!HObe6YTKcw'M8p`tў-@q]^6u}Z@@ d4MÒVqSP|>DX4{U̹CwbIi|O:w붿R[/iY=u͸3`.ۧ4CH̩͢ O<ѬLɯ·D/h zfuz?sUGX4{%}'s0=#%@ gƼ)7ZR; PQWibͦ -gғMά@*KW!ɟʠ#IeuH W:;/fԿIDATiP܌EWQ^Ÿ+W5uJi[쌋,J+b~x.u;p5P5شUk0B^2mP5ImܹfdIL`pܻ4BNZLTA;z j(< %~-u&{8(鎅w J*~dIO֦&-5P&Ыk4mð=j*Oyk7uq6?w%կW_绿 P;\0krqRW놁FD 쮆yUT֔QQ}qi5SW6I5S{$!?'Q>M݇BQR^eD]km';gO ^}^}UoӨ9]ĵ]rEk>%"?yS8 @(E2JeHX}ɶYVjGx;5^X0s%ojaΘ7Jr UI3b`;~'-q~Wx,?e~c=b~U?-%/˛{N{Λr=Ň0-3!hʩw|)||FgѭƑ/ڤ-Y=>,+ͺx+@dEGQ̾ F{r/RICw}v$9Mugg MIejSsh4.0tP8w0 3%s0wPrFp#YtZ@V ͏TT'6R]<ɉ3Rz^:59$&9lZ$y-!ёգ I?~3Eýw;il.I!; j ,iEPU5e|'4i6,y;Hp4wg@4  r?qo؆!t_UΟ?{Km?=;b6{5k6>~qmwpLu#oU!U$=7Ya|O՟>벒ѣ{, gblr\J/r¿H,V^Hc$M(>^4.,y23%GGqO' VE9a_#iyͿ6^v0ƴ]ۚ>}(cD_H =M^󝛟lTR5w?{ζRǶ7.)yBRSlۖKmm3%RZNdw,#X~ǔ񎍈1FXN&{y޲R擑B^^)/zK1txPimae٤xzFK.q4\[xZ\M͗>;uj G8l0a)a*/u M+Kl#'2;q3Uʖ?W̽;&; @Z3Tg4hLs3wn G:v`p `%E~9EJ|3YR{0aTזƇѮTi.y^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@l iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAR?P_ZR5EEDTTOP_A֨?jGOZGEUP_GUDUD~muQDkOj#_ZiRZj ZZ/֪*ZZA '֚խ/j֨?QMj#j j ֨?jFQEF/(j*?Z֨5֨?ZiRZj (Z5(jAIZZ֪j I@$ $I@$ $$!! HBB$I H$I HHHH$I H$I H$I HHHHHHIHBB'#W Wf#Oꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??N@:9`P@? 3? 3? 3??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 19PNG  IHDRcIDATxyx՝?roFY4!&HD"ZA[}FciԶЩb;3NU*ua!aIXH}ϙ?޻%&Y͍^osY^;OUڿAG")b).w#f44]FJRQ p݈M{rئq[< 妺RJtPQn\FHOFt&%EH$BZi00 RQ!,0L妢s%EG &%E8H,ƒIsjhDJXh\x xb[[X=W"7"`{{-Bx(o. %@襥hd[X<s۷#e:w^ qDFH5[pp@Ėi fnO:^yx'zXz6Gδ;HcoB!%klZoqohf̰q}^/)w$`:D>O @p*QP㹲;.˅p8՗1;[Qo Rn!]ICTSpq|Va;Y oHN:uPK@pW'c[{Q\P~RJj.rQ\%/ R dgLg*|I8y0He1E%}GD$Mn%/=WdSϓHrg/PSʅt+!.!-&ηgŧ> RFuӍݽ2C(hb}g\8Auñ! Ht-zYw̙33f f ~[n&wpFӬf{iӦO=W|avQw{ Mz\9(2w\~f'HQB߂7~]\2)뷿z+O3yd~{s7T oz$#!V!4MkVZ^״Z) u)%ff((e}`]>lKhy$7W'0wUCJɞCic͏̘F\2v9O/QkuNʺusdG+[|ODssOqd1!O&z$ {scFb!.iA !,ܖ w6.o3| qdC5,_c&-,ͅq#^%)wc!Y5mFCe;wTyr4$rफ़JL0*|%Cr|?鶚tKKϝBJޒ>0bpr7.\X?Y}Y߳'7Mn\*uyM+ddd9G# cD@#߁^o`sORu蛦`&ej.Ԝ"2|GVm\2:t[+ <7|O>{|9.>;9`iR˴q ^[+4433&#ۅ?/Z ސ-{n&RҢiVZŢEyI[00t6kTk53d߉p6@Ee e'"'sN3qXv`n~ԩ2j~GԳÙ>~rv]!󵻾n[XtrYn7 9qϟ+) Hk 8Y[۩%x$Xw{Z!'s6abY..Ww>]%cFęr?̈i,;?P;OB&r7`rC u%ȑH{:7zx?g9ӟ~}ւa|qܖ}%;YAJXBM vLoaArbg{lf6|P^Ȱlgڔ,]Ox%!|ʴn!b䍛돴O~wZ{ϞG #]ŋ8xDכ=ǎ p\bر+W -M;KON1Ĭ屄9~d1C E+7-^W_m{QJe***|}:x'lmZ:{g&O̶mؾ};ś^޺O?oX"ÅGbu[xP_Zz׮]L#ʇKCy픗:t(yyy  l6ރ߁;`=m>GՁn,ä́Dhljk.\QI@ӑ{c~ӟ0w\JJJ.%RB ?}O=TӦMc֬Y̘1T]cǎB WgyɉPĮV&befL\|-9v𝺦/u0|`˖-<7e L>a̛@qŠAΦv}ӡO:{qONJJJkX[WՁ<!wHQ6~)KYE~~>CӲ(wfÆ ,mp#8q&MDBkW2f"f v?ѓElܽ )LYG_2?\wuzHKh mUI"گd8uƍ< +W/cbVZEjj*c׺CkD|։r1+ʪc|#RJf, bBJRSgKj$֋@dC2W']#xy'HHH@_wA;GVXߵWaڵ\ayL0(-Vbza-7Mٰ,36}} K&'s 'K (f ={6 XFm}/@uUWYLHPG9qnɳ)? 4,=ÝY<<ϳ>KRRk֬aÆ s۸|qƦ@>baxp?5WX\Ƴ 9w2Y]/a#d(**M6U\>cH,ek6pqW{xXp!Cyw;k,zN}NKdffvY7KK<%㐽xy3j|ٲeaԄ*([G 1<_׈%\'FN»S4:*i?KC<1Rqj}I/G'Tu$BC00Lr='&?q;lz.ٺECG#myt@M%q=pgeUV18x`RR\E!- L }C;ŷ2zht]ŋ,Yz,OLep: v:ٳriZ0*gΜ J?+_"Ş0:_=eи$558qQVKN9Hz=^{e*HM ogܸt3wx]#J!gH5%xjh&ܳ'αdɤ-TT#,mdzڹ876* ӉRtkpiy&?HMP"}w<9vV j7ow["Vfv2߱6CPVKVKҨNԩ7Q]@پ^ !,p#T frEn|fi9 苔h0)n%,Jltb̂`ނ 8RhҏxZR:(h7뗞y3,.^:97}anʕ}lƦz4Mc;xZGJhfY%EHg'>yGq#x!6u і"$!z[(ˣb-$)!|J< ;̞|Ra 7qV)ˣBA q}pNa|(".qCeyAXM>tpʕxA(+ܶpL'4M5"$B=1="21M'ΗGy*Zeho} vw}GG:CgO[nBw ģhe_ n`ne=̊,g躉F<"w~pI<<מ6JJij;;~H_9yPG(rO$xn)\L;!awl>+≞hQ[F6Fd<PU}vSXnyey`44.SXN;T^ 4A$py5ںB94EY+RvZ8,D7O\'(\H)IOP7r&AB|_L#8 x>,v? \HϬðssG!pq88 s C &?~64DIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo13OS6A_ConSurf_DB_pipe,,,ptf?13OS61?1:?13 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@l iUQDjZZQDj ֢֠kR?(j*?Z֨5֨?ZԏԏGR?ԚFI֠OZEAGj O*UDTT"I*#QQP_(ZAEj֪?EQDAEuQQA[]iTQZW֢ZkT֠Z֩?֨?j ֤֩?jP_IkKZ(TjZZj*?Z(ZTkQQKj#Z֠(i(֢ZkT֠Zj#֩jMj#ZP_R֪֟5Z@$ $I@$ $I! HBBI H$I H$I H$I H$I HB$!! #WWf#Hꪪvbinding site for residue so4 a 400ac1G#1vbinding site for residue so4 a 401ac2X1vbinding site for residue so4 a 402ac31vbinding site for residue so4 a 403ac4 1~binding site for residue so4 a 404ac5Yf 1~binding site for residue so4 a 405ac6AL 1vbinding site for residue so4 a 406ac71~binding site for residue so4 a 407ac8EI23 1~binding site for residue 15p a 408ac9U 1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn1vbinding site for residue so4 b 402bc4F$1~binding site for residue so4 b 403bc5Zg 1vbinding site for residue so4 b 405bc61T1vbinding site for residue so4 b 406bc71vbinding site for residue gol b 407bc81met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESoo1vbinding site for residue so4 c 402cc2F%1~binding site for residue so4 c 403cc3[h 1vbinding site for residue so4 c 404cc41~binding site for residue so4 c 405cc5CC 1vbinding site for residue gol c 406cc61vbinding site for residue gol c 407cc71met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RESpp1~binding site for residue so4 d 400cc8Yf 1vbinding site for residue so4 d 401cc9G#1vbinding site for residue so4 d 402dc1X1~binding site for residue so4 d 403dc2EI23 1vbinding site for residue so4 d 404dc31vbinding site for residue so4 d 405dc41vbinding site for residue so4 d 406dc5h1binding site for residue gol d 407dc6X*1vbinding site for residue gol d 408dc71vbinding site for residue 15p d 409dc8W1met->mse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESnn13HWOZ  nt|Z_֗kRT_ZZ [TP/j֤֩?muOZCVB?[_֩?j"""H$@""$"Gbm!pf !BB!!B$I$I$ !B""!$@ ADDDD$I$I$!B""""""! $I$"""!BDDD!!$I$I$I$I$""!B"""!I$IBDI$HB!DDDBDDBB"""""$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT vbinding site for residue mg a 1702ac1l1vbinding site for residue mg a 1703ac21binding site for residue isc a 1900ac3#\_*1vbinding site for residue mg b 1701ac4k1vbinding site for residue mg b 1704ac51binding site for residue isc b 1800ac6N[^k1?333333?333333?333333???????@???$??tDZY@7ER@?@f?@f?@f??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 20&PNG  IHDRc IDATxw|̬z,ٲlٖ\4Cp9$\ .! %"˒me8Z] sPQSt"*B.S*ZYI!b k_ eaY BXaanwQFZyw:4GDSQxc3C(#N`n?>,UTLTME4Kp쓡jcJhjj(fy0UGP/[\~~4T0M}_Et+# R={(eӥx6a*RXRANj u`i*Q;Cݾ(#Np "UTKRlU<٣xLÏT,R,(*92$CTΣa8eI<;ʊX(Q"$,?wAU5EES4_&FXCJ KXz↫mQF8!1̺ߋnx:~Ça=y=ea"Dr"%_SPP/5\.`qsI***xǹz}dUV@rrf#mmVw-8H s\&ՕR[WC7~L: 1䌟 Gaȡ"JJJrjsQ]]MSSYYYH ˲ӓlKtn~ts-^RSYt۶mC1?̥̆q"{.=9~AjO'Mw_a+%%x}ñ8߇aPK `ҥL2SC͛O=_*A L\ GOWdgNgE~~Ë߯1(G%5)w];)\&[PSW!++_-Y6lPxy<:[d[7ꈈx:2ƅ%K\"&MO~ȶm!r'ΗK?Ebٸv Czt+> {mK|k{&ؓ/ug3f`֬Y̛7x`H9fϣ+#$Ƨ#/]oŧm7oko͋b]~/,,iG=MMU$cYͭTSU_ahqz?=0kyUxc\;ڸơHCH*25{.ET6e䌟>44W^4Eucem(..fWlzCZZXX̙3#㉻ 1>LtŭdgNGQ[i8GU] -5]E@<+5B}}=~}?8a{||c"edMD"]wD\&P]_F]c9'$s9֦`^+>og?{nKDVF. 44WQY[Li [LKU8p1_qwW}\e7~.!O/ R"%d1i\x #g,RRTAyu5gu ,FL=]];J{ᄏV i8OFzƦN`y$'PPAYIދ0@r$#/ Ꙕl#¢FL2+ kFbZD\ƧO`lj6iBELgfDeu(@IzŽqҙ}޾"cƌDDԫZlIJc\dPPJ(4?=8j[1:2 <.=}/g@mmmmFz}-*7B!9~׭',ˤ4RJ`!ɫL07SeTrrl4Bz-:򈉉ϞS3!?oG;he˖N!Pa0T F\L"7^MNK-i,xkM믻Y7y<tLI`v2|gP4iҤNۄP>+uG܆AkpdogLtn?Ϯ(>wHͬ,9ѧ];v>z(o6ϼl9r!f?r7x:m7;7(nOo80ٞ@BUTV-܌iX"***z?qBpgb[2[3f *oB2qdN_DAAA'(v@ӧ7܃ipib=fCAv(ƛ{#/uqy߶dggIff&)))\7{6Ǐo?0?-tvM )%w}렷k(ya`k9|^(*2(:l\yW}WƊwͺ_zYs=ٱk?_Bn}^*,'SO|RXX͛78ٴ/k]oE5tQr° TEuM|gyUMJ߾u׋ix<{AM;ٗ iJII O9 PbBOCBnɓ z!]E:fPgٲ MGy G/8:fui`zȾc;m6 /t۞r Z[[Q~lgT?[>/޽{~#>_ƒ08Z8r=,}o 2r'w|h*40 Gu^zqjB!a:MV>|͛7tRvK{gݺu!u?A#<Xŏ~#n&n3ό%7KW8&|@ p#{{]<!PXLG8c} Pmc9mTוmtNz4.~8n\ի)--嗷s%eM<~;6mr=lٲ;sY>']'ḴwMӰjYl\36sGp~]kcLhݶ'T%\{g>]w˹!Cˎy#k,hhvM-4q tsȐu!qPs|5@ݲ,n塉@3>\f߾}x^N8џV)aܶ$2K"3t6pg;QnsȡC~ R+VyA_/*q(¢`OY"TZ̉[*,,n#--ze98#9]vm(SQ"RQ\'-y e 91 !)|&L`b/W{i';ߩ!fuA}S%iBr08d-ѣG96'3w8ϳ~9S>BʰtO{]ChŃҖ9y}%8e,O}!zࠟw p:b'M&gڹb#?o'!&{傠NWIekŦ,rd®y;yG7ׯ9t ] J Ѹ*+({ 1o8 `46d EqQ#'awȮX+_`pH=jòr1bB(ʪNu, gMG&-a׊\0sRZViYNYxB((ڇ%M緮8}Um}nBaJ 3Xk.,EhpBLΝ9UY"8iؑ#@3?u}- fki=y]'.6-:S,;=[eg>mZF j:BJXP-m a /<>}ǫ;I .&D7<5>6d)hIS(D!*٠9)‰Cqm}nCSS}ۺb>7B3=hf ~ON |18B+yЏ*:hik119m%^}SYW쎐Q}c7K:3ꑵ j:~CG^ְr=Z,-]8A±G8el T}H.`~kuOyMNJ '#Ϟw9_쵽nt)z68Z˳zftCGb4)9뱪 hsK`ۛ~q>]FKN.bʫO3~VpfLYk)O>,zk*M,E#]l(j`j zN86&]|+*tPz{SUB'kTtMuB& MZx}u߃Em G^K $ڱ[pMȩCZIOE"h;FN, f7r7|4uI4e 1!"b@Qa&dq8V өZQ#[4SҢ%oԜRlGv7(q ^ <;%{.;qF;?(+λF'ޣ*P~rz6#)-t;b jl CkDB): qNdilc~ j;͊h!P44UQRY@YIQ' ΋Hd[3ctSwq$!宺>Jߋn@D]ͩ;h\CCSe'@B~r{鬍"RqBfcS^SD:)`Yk}44W#bu/SX{8$MȜFZ818qC$ y_ !nHz|@H&fvgvcpd1#"*] Co_ڙ~Pwۯ_ZNPx}>!3/H@+tN$1>)dMIC.wpoYX0V\~^F) }Тoxv4L`Ǯ_;Re(,59S\U5,v" D"kI"-y (/0rjjYSl-I,>m$$K=O01?v*gˏ[$5i nPRXN]c9Y)9x-t6o3~SG<, c,"Οs\4{p_%*If[#?wkpD)&ev:W'M~Ңv+f^@b|)YdDRh+'Ou}.,ޏ%-|{Es} w(8NjqhM17oe"V+Mx}mhm@e7a t[GbDe莿 o%" WXc8gU4 Ws̵mB{i^4M f PJcK / RQF9U yv!DRr؛BA8Bڴ.6 PDGN'vʀUH׌i7t4M#=%+knܞ}m_Yf$kA˼IV~}YJ?}Drpgi$/~Xk'!sqz∏KB<={eu&VT]ͣrIENDB`move=1000;blend=1000;3OS6B1'(R 8    )$)0%''%.4lѳPNْtR3-&&N yj`gb#jդNbbh)Ϛ.*/F;mbJ J KG I &(8 *TS3^{%뗮f͛VZ,ZٮLJJRTJTP0 4 ^JT\zfKL2Ǔ*^*UʕRdZ,X0BhO6z2mVhkE4jVZF3L Zfѫ6TAi8&Lڥbh;VZ5hjL0/+-fcY:^:ŋZ,XW*)0XV:NaYЬ+:,jKCN uc]u炷P{iV͢֍Z4ukFJLDL-.4`XN. !q) b"%mH6 .Pku]y]yy^qՋVXѣVZ4Zs%̙.dK؀H$O%^Dcb1`D`<U9E%%͈ 1`t0mK$Kjd 0"ŋ<ӫ,u :厺՛6l5<&ҔH[6' `8!0A| L0% p C兢Y(iYQQYFM118|̴٣g K H II E0LNN@/% #EEG O3-2&6|fL8^VdP+.8V0RD"t[mQ+ԫD拉 Bqqj6U)U0VfѪT-jժm3\՚*5Ps6j)Jze̕".ؐHű PD6 [`"D' M+b($a`XX@tX:i8h) @T:'NI@hzD("Vs ӟ@|̸ tX"@JPTDFĤ"( EQ+mXN4h6fbfpY%fefF N^pѢ(KѤBz4!hmT+Vłh!F 0J*SǓ.^ Q#F*T̔fsV^&d5.\CVLjդd2U闯d% 2^e*RLy 3.$)JJgئR2eG)JK@l2cǗRy+ TmmNlO'8fZP[lQ"DS'm[l'6j6ڒB1#b1`p `, dX#N, B,[`F <#XڣU6 mGTŋlO*JmJɗLz&J{&E .^5/J"kf3&GfrZ4\rR>2jpF(P2 W@ @bVXmse selenomethionine MOD_RESbb1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine