eb3.6-1h!/data/swissprot/ 3HJB.pdbdupa 1GZD.pdb:o[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.5 Angstrom Crystal Structure Of Glucose-6-Phosphate Isomerase From Vibrio Cholerae.[/h3] [p]G.Minasov, A.Halavaty, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3HJB" target="blank"]3HJB[/a] [small](deposited on 21-MAY-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [p][!--icmscript name="42" display slide=slideshow.slides index="Ligand binding site 37" --] [a name="42" href="#_"]Ligand binding site 37[/a] [/p] [p][!--icmscript name="43" display slide=slideshow.slides index="Ligand binding site 38" --] [a name="43" href="#_"]Ligand binding site 38[/a] [/p] [p][!--icmscript name="44" display slide=slideshow.slides index="Ligand binding site 39" --] [a name="44" href="#_"]Ligand binding site 39[/a] [/p] [p][!--icmscript name="45" display slide=slideshow.slides index="Ligand binding site 40" --] [a name="45" href="#_"]Ligand binding site 40[/a] [/p] [p][!--icmscript name="46" display slide=slideshow.slides index="Ligand binding site 41" --] [a name="46" href="#_"]Ligand binding site 41[/a] [/p] [p][!--icmscript name="47" display slide=slideshow.slides index="Ligand binding site 42" --] [a name="47" href="#_"]Ligand binding site 42[/a] [/p] [p][!--icmscript name="48" display slide=slideshow.slides index="Ligand binding site 43" --] [a name="48" href="#_"]Ligand binding site 43[/a] [/p] [p][!--icmscript name="49" display slide=slideshow.slides index="Ligand binding site 44" --] [a name="49" href="#_"]Ligand binding site 44[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] 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DC"8CBAj:1k^wKdWk3Wdze-h\,  &K=qkwq0AhK2 TgwGdwc1&9&9$r  s  ȇ98{mfٌEg;!Hsm-5%VlzՑ׮9 HH9bbF%%wvim02,UXŖGP* ,P)Ub-reUU,xH&,]Hwgv2*JG((eE-,Xj,XZ*msȱlVN[m:mvs5!vcWDc!q48<$ĘĆ"!:Dc`:= mkObǬ-Uc#vI$ֱ 9bDI iD:2;W9D919 fD8]^di,ZDP-Jm5;Dggd$EvجRTgbF:!$8xA%fcҲaf0с LГ=2b"c eU얪նǑVUvf$s]0mJz p.uݫ]ΆzՌc`P $0 zr<, WhXX<`0T ЖA8m:՞c -ǵ;wgv=kY42Hd[+Wd:!I${lmuJsewEK\ 䊏 VUkiVSY-dګ**ЗXu!!DY=w 1GxWvDaD!4C9c!%9Is@ !cagIdX=UXHl9)UVEX,Z)lE)bȶ-Ubǔw RIXFd3k8@4@p'-g31-klWwUKUJz"K\*ZI%kY&;я]0Hi C :#";gds$ ABqD"]K\DUJRx!JVHU*X-Œ)ЁeXXX uBIYduc+9وCPX,  (`yVEX[VXmjy]ܔK,ٝΌ̇ D>qc8b %Ę0a#& (8P4( $AkK%XڥUUQe[+4㻡Vx - @<$pb@p`,X]ק1*YZY%lIlYV]A뱙gv;Pb9,Z[VӐ8ҩdRU*Rde i$,gKJ,i%ؒE*زJ,ej96ו޻$hݐCI bI1 Ò848pd@@Ǝ0hF@rA"0`&@!"" 8@8808@D<<<<`L F >HHp&;;#]΍-c#ƵKU׮8tKdF 00^Xp, hX=(v;5=,@YlfjBȃC%s"9dz2JU ,rYbI$ȶ#XE[cy%t Ijc4J%XH-w*XBYT[JUWgUZHUje)b*TXUX4mUlx;blGvC0lI$h!;"vDgss DDdCrD!",숇!ݙّ# EَN@J9$`q(  `D848(0"$aGsIs0RMHeU-*mI^ǯk׵$[d/,QjdEV,dsq 4q$qS `x`4 A@РhxBE P9$3 -EIQUҪ̆C(I 0@@ $I]8т*Z,^#hhP"U)bT*uQbR**Bj4v2`h]G G $PxyrH fV-sG FT (,a` UdX$JimrldwdDq]WGdd9,8"2"fH kFHc)adXYVVH:VUXZey#!$S5#AUK#YmK$ZeyGy*Jc9t!`x@r]i!R] ;*ȫYpjŮUe"12,dVGF9'Y٬Y,%TI-Gt"-b-kVf:H8x;39Q!B " wwi-+I$#]ѝ݌qD I$$j4Yph#0RZ"Xe,fabŋQeXU0)k$V1 $i Ȇ0{esz"KKe 5:$ymE 2kqk8pyjkZ;E< %vd,zrYXphYl*TUR"B{$5Udw%v$jŒ;e#% $q3EDc2ő8Y%dfXZU*eV+Œ3JUXlRabdZ%{-evy,[ڒff^>j"NLGMڏp:1˵Qk>QP5ȍDϠ|ꩁls-y%D] ZVTn;@,X~e!%@=$2 ֚^d,-$芴bZ::C@HH>O>h;q8㴋X4g-gy26"SgKx?XVDLDE$QSuquRĕ0y0ʤp=e { |}ce1l.-XOG21L>}2@3y, H2tb>|W?}gB ڷ). `zAj"uIGܦ8:)ں)+awBJ&GG D/ec5%х)ȢLu.LdIO#i#Dq*JdI]7<ɸ,Q: <35#D2:d9ӗc %iDΰ?p$cϓX>BNں*.!N%(ݧeb:cZ W$Fd{1H:+NSCiX)D]IӠp~fZ;7ߕ3aJK*hkkGILy CC7# ]0L2A0IT𡨚h 4h ,pTޤh"3/:x'E?6.4EZ p42~c:)jCnegO[@$օ|q[L-B`\! 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HHHB@  $!! b@W Wf#UUUUUUUUUUUUUUUUUUUUUUURJUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???VN$??3G{=@"9@?ة?ة?ة??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2?5PNG  IHDRc IDATxy|]ekC4MfN阶LB`Q@9VD@Qx<Ƚ΢9r^䨈:"( B)M34xXk$m4׮OZ}ߕyfb >Nm>T9IeQHhq,;qR\ '챜S.&#LS=X/(-ŧ@0 ˶`>R7Zڏ! `c;mcca&ce`aZiP|pW:Q$8;OInwx35SR\84#N$N\Тhz۶mpͻg8SL ihzPw~blrEfϡH$J HX^-4 L²m,xۑYhiDП$F(Ғֽ{k\(J,&ZA]>` "ei  nh݈`[4uƗ`ݖ_;8mG#56RAm*Tc!nqCwLADD@E$IayBelB3CUf%҉ćfs*P^2۶0-]wzHsehzHpU{L77eǚ# ""b%DQFeT5"H$J\Fŷ~цLEUFq~gF?(-BdCn$Rmzf8;>U(. +VdIEU?~_6A_cٹ7 K*xoA7$7X$*N86N% ]kF3!IŘ$Snl^y)Koebc]S4YRDx"L4J{#w 9?EsSUQEg5ji$( -'lu(V""9y|(YV21-Mn~F:[)Zpu@t1xeW!'}p!%q[ƖZ1uD rssE/ DDDb=gЍDxXN#*zCÖ DA|rUKFR=9t\0ĵ(D;D˶\C \YMqA%m)reTU 2?f9H3\eچfT-$AaDd$L+Tv$loDzL,² Wm:_(tC\CQrguu7CC! GDa"?cς$*K[T"%¼ yAcb&WC$DVVc ~1LE5Wc6h3 -/(6T,,hF# R%??\Bmm 2EBbQ gȳ;sD}hFp䣥( 8${U[)M0;tΙ!$Q=!ٚ7ۆ`6ƌߗ 8T{o0zhi=9WzZ*˲ y ±V6l{~O3xdTbɭq,|. Q于'=X ՙ踚H (>|N,~f1zEjdIA7N׹?AD^?IWUpΌݿŖ=l$m!H<`0d]s9t7zIs%HOĻI HH}Pm~ogyJ 92 Z4^o$taOnA]$S/¶-JFCU~ԮfG>TUu t MK"'cuVv7pz[?`۾u$(q-~y g8ǯٓDzLgK rJ_2eI%yNĔqY gV m. A$zj;^FBK}^:{9SޮL2yaf"grm[.(?%@' eP?_6>5HПCП")<܊1çsN'֊ZpΕ{/.7(mqݒVSE^N1b t00x8CiNB! .jYRimk#.,@7zײm '\{ D4-Wk ƺ"_ N^hOj"t%aG''͋T%ahm'! ,tdfV_Y:EREꍵ\8Lu}E)8րem|r-NCCU퟿v0u4-iX'yZnN|Gag<9( }|h9`0եw^v_-Tl}7fn6s=yfW>>~Wݣ Z0?v`ۖNIJ{T&,^c#%ӄk *{7UqWOg׿1Yr EEEqax nٳٲe G. Q +Ѝ8 -N$E:?۶]);w 1zyF61o^צgs=o{{_ "e(Zg?YVZcǎB!nJuu5[tF$lZnvȲGΝv1mMQV,N=!/gaҵ5 hزlyӖeqIlٲJ/d̳]֯ἺcHNú;+<{w;ƍ gK,hl,nxBVfR&p7۶xFfOiĴI۴-t~bӁ⩧;￟lwaŊn^'i۱m;9x晓U̘1*v+`/zT|Aj#(+Ww҅]m IW䚮\c͚5,X}k=_r%V_P# *2eYƈ'R'I$N"@z_:}Тض7f9DvD㎞{5pIxfz7mw7|S &W'%SaʉD±aFF)'e[(l~K WÁغu+<#Ǔ2VϮ]صk/梋.OS eQecZ:@74,}Ű, 0uH$BGG_Aӽm[({gxg;).._k׮=n+*,^0AINhh4'yyܩ0-U ogJ|DQ0ut3A\bZ:mu*WFD"B~ _>!(/çьHGUUEUab=i$ =Eqq1W<-e|<g?Tdv Zۓ DA^: =hh>Іw}7S7~:pZ͜UaYH;9ȱX 4b1/ iF6uM{/_Svܹ?[zZKKKiNiyوDG4v fBhYOmbj[h Ov#NrOVj}N_75pT&7QihȨ?--- ݎ$z3Lsg]1$'\|Azlo ߆} /袔Z#""Dp-\ p8L4lôL :wůx啓$M*Bk~-naŞx4Û ȓ$MzaD%֐ TPy$_O~)O>zSUQ/ʥV݃ eKr*ȡPYv x0] B=ڳöm'm&s4_~4Yzu)`\}OJYK>˳o 5L((HA,c2)vBn򰶶6iii=53rnpMtMylзmy=s+7(cP5@Iի;XNģ>g߯O).1Gsh#{o,ai >Ըᜈ$I'%=Ca$M+*۰a]ww}7{j#"U5L΀ۛiDntA÷-Zm98q;Sr'Hmu\7iLEɴ^@'Ӌuƀ#d8Sǟ Q`m5Y9Ұ¼R$1s~47_N/Faa's\j DgϡLw˝8- GO~ҫO og?YJ8O."E1-*,AE4]c7)w\ndK-D_=ٳg#'Qo-s%{`|?Hެ΀ئ=2,?HIDATs5 $^+Ir\\~_pwpyu7Ɨ>묳xS&NWs(XX;h;X;mDb!f̞K܋Y|%ԥWvqg>zrHA/4#NBegz(0SӺ떃a0l!o,_j$suN.u˲PйYex",(%C5y#)LvGUHG\N4֦Zُ5?§'*ħsyp}7:rDYi%gMNy1o&6uM{]P@{jez9$9$Y?; |Af__~>K}v6mʬl"v;kG CC ODJ +7[PE5Wg~dYv:Ô J^rc'"a,B}y$7KՓ 5y_sOo޷ᇙ31,sOζcY&9 nDQA#ރ fÆ e]6REG=adIEUTO8 WG K^$\U %;Ov 3yǏIY$ r`Z:[jE2r%Өy&o\0r&Ww,_Ǜ[vy,ӲLR8:罷zkBNQ)Tw.:)wٗIb:AjUwile-7894*&˭7>/X9OE 2 B~ $8`oHA=HM+3C# Gۈk CEoۻZڄ$ýOinO?q,^Áȅ# "(*~|jQxaжʖ\wui?C&%k,)}Y^܁"c4#N{%Tl|Ejf{o|;7jW_чOĬYҳc   *E Yi?I^2Jiϡx29B S72 ^UQCɨq̜z6sfe ܹL4Nɵ~Uxh<-M<8qږ~V/_Nvv6"SSSI$dggs饗o|c01|cGW@ n!:6 ,`gSQ2rFW0 _d쪊3S2|2446.bhݶpGn>M;^<htA9yc #2zepaQLYH2-P#Y\|JO b$( !P$CŋtRe܉s9y KDOsT1d@ѢؖA5D7=M^[6 E[#FU.FVfٗIu9ODE[hhtBR2i9EgDফaSxau{8Beœi';_"JyNHh1DjXC8 uL7\:8%>3Gt{]V츱(K 'O]eUsuLg͸ Y].¯sD8\HߑLI2  +p(I!pu?gLomHW[g00:ae9kbT^)$$1gȌg00̟?7RSSCyy9fKa]J>˭č$q6eؖCJ]4"3i:^(Ĺ+ǖݯ3{XխW)/ a܏Qޡ1;ޠq<`taǨkOG٩x/^2uW=xIipU9g,ΐ$#{d˲SIWsYF>uJ=`w; ug<-Nΐ/޷cC!;zpE+yhZfzfO~! lz'-ئew1bsKYv g\xr}vxXܢ^䆥er֌KW\6bN.rاK2'"ƎbeFE}&3ۑ>B\0nos s3lQ($)wYc_Nw)mcZg3.]cW:@O|߰cTXδAσu}{7,d: ,q՞&'~ IA%Y<,$Ih V=MO\}.?_g8,TOv "rss÷X>.k ?R.s|Y!KsyEȣK8DprK$yc#aé054=N$NˆnYeFDu9Ιq95 {ِ$qOnuw \{Sj41Ib. }iH*7_u/?!_]';sÏD:E/^Iu4buL29pbđBqͦb>/?{PfNH77mMmGK~^S LHe{#f*jeʒiHv #iH&-:(`7R?y E7OH$GgU%x1:h'?g4x; e=Uxoǫ\;5JBdY%ϥ`ZvQφm/i߉;S4ұL=h=-LcD['")-HN0>dVt/{;WA,Tl|KϾԉ'< N $}:,B7M /gt#4BdIt25/s։8z?u,s%~5YL,.':+#9v|捡p)=QAiG涣drrMUSV2EV%"TU0|.*jw$آ*La@v c}W7Qy(%ʴ&.VVs]"ף@7┎"7{4y9?-ݨMJwqKݧd2ԼNWd<ZYrK]%A1ܥ@roU@caXVYZM]^4=AfbB66,m[OTI>ρO'cvK|Bhy;˦e "I눪)A"v)$:6_ ?M0/GsZhMLs9z;l9 q-ʶ}klcUE '(J#-翟sNHs(hzp֎≈#")Ar s$kDeS4G 47prƏA\vq4/w e=Ŷlﱝ+d̛n(=JK?u}k*-IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBw0eX!eX/  UUUWUUUUU*:UUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeQU꺨 ֤Z֨5UUD֩?'*TR?UR*U#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩TPI֩?ZEjIHZZUTR?U5GKW[H֨?j @ $!! HB@AA HA@BBAA! HBBb?WfW#UUUJ* Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???vZRv$??K`9TJ@? "? "? "??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 38,PNG  IHDRc IDATxw|3]j5w[rq\0`Iz.\︄.4HCI@ `E[My~L]K>z|G<ϷJ f.w"D EjD]΅$AL jQLG2! AH K +v{0bp .ŃDZ @>O/,˼vhܑd( $͟I8RώX9S # iqHzZ6n3Wtx`C耄>\E}!'"KB7.0 :$5}q?ZDV1|v{q).*kNQY}I9͟$IL dMMICUlJ'i[O=I|~ea< C<>BIdds$ݟI i6@Пb[:yPjSFsO3|Hȱڻv;M/IBϛFПI0C *y[5FzZiL'fٍTEisgaܸ 5l9vj/F1M  #MzZ~E"wUH` /"Dۢq_gȉdg@QdC9º˻[? ;`6}A>OH6& ҭʦ9[uDS_up)n38sjr8;nѦ&J!#m~o''os{-9zD ->jQ‘:#5.c[6aph|ޠC"{=(.^gN =mrvHg!"zBlvw! M?2xA|cW6Nw}JFpe=bAQWU1Cr=l&MO?G{ТbP(.\2rL-U#|u@6qK}<6"&+GП@\KԅZA~_:h=UC#K $3z>Eq+@"Ԡ$(5]>n1{-6y H4D8Z$H'Pgcuz{dMup)Jghu$a忊gy NO]ʚr"z4Cpd pLY6>م5w~4>y?H 'w WUUk#i@1hh-B{?ZBDba I2.mp; $ I{مKR<疅aCu|)P6@x# )s :Sm+H2 1X j>Y}Cn"["#Ab],]O*GvҀp $$a^Ɏ$ ҿO=+jd ٨!eVb)Ȁ"I$9e$ $!i*`{ W~O- !aQOIh{|߃@;d.a!qNIp,OJ[ͻW| ?~§A(9\2f tuNnQ{)ՈCFӖEkJX*}Yl; 0$JF]aS#6Tu1jTM)`"&&b{b1S'KvS2bƏNVf.U5g8ukkHBR0aӜ&?ղvn~Q7g+OQ~(Xiwh$ᨡS$@f7hړ1A "HP'qW0=ޜlBM,݂"%]Z UW=ɑ;iQ‘W摃#Nx6oM\:틦kBuP5pp5CKQ((ۍ,p8Lyy9Ǐ7yՓЪ&ƋL:(Jg¶9So04 !0 UWѵjQZCǷMC(RK$Zϰa{Aݗ쉡c-Ac'dԗ_i <1t]EcZڞ.ۑ=ۏ :U5\ގ6 uq+dIl CgS*`c9ZtCGsHc5]sXϝƍd׮ z(3mڊ6dgV_O}kmtYPuJUZWա*Gwr=wF`n2]#|ByN>P~g|ME hM!hnz뭔crq+T]`gsF8>i7vXbBpe":u*[laǿ?68 aj`mEҍ pnԻnhzGk3N/}<ڤ9|VzYst( .ؠC5)mB c&}:z>\.bTzA kLe}/|ӧsxjxDTzj Ra8VE%WbV^#n]7 ۃkɒ=,{l_8'OXaZe˖_6_hK F4_䩭Hiͩ# n 2c=eܕY|r|& ґe]QX}W-hﴬ]e˖qdk\C)L屸>H1zf[oSyCpYuH4HֺVVn@ 7 alݷ3l .+6h݇0k VYOy%w9tUǓ6u-VXc(a$rt`--YfZUݧ=%V8h 2w3vpr!\_="g˹%v[Щ*O,'F^ԙC00~64]EUԇE/_W/SރNQQ}ŽpH2 JATg#^oɓ<#ι7y}II ۶zy˘P4SI\$F!~AWLVzneXFB^|E**k/^̐!C?~-BZUǝ6PvFJC- ±]t]wS復6i&L1Ӓl¤I.\HFF6l pQ]zmCg͝2 IvBacOgO$D A]Z,L'V5kp׳{nwɾ}Xbsn =Vf)34ڇ|[4FI5p=ňNfL5H_~9O<ӧOॗ^W^W_m!8R)zb&yAyCB8eIq>XͰqf]_$"DcaBU*# VS_;1۷o_f־ni)=ĉnO x=$IFd./fCeM9!8%QK/`L—oW4-F8VO8RhWdy=eacҥ,Z(g?Yqƍ?9Q$bH $¥Q$f1WvŠ2# C7Sbh$ à{?rX0*w7zؼyxl2.lެdH@V+l?͟" ]kbVz$̓(D-IFhiȲ}\8k2̘1Iyx 6?Gs(--{wi^zX,ߞq{dvw$GF@6YyagqtP55ug%ĉfP.N# ,\,7x+WC%mž}O4F_C wr({$ѴesS#ZI?KMYKcjj8 k4o&wD"<\'|_Wʷn:3g}V /ȑ#y饗sn?důttg6)ؚ"#m.Ń$IW74 ڮƯCa4wM71l0qC=ĢE8󒮽뮻΋&͒%J$V#kbڵ0bdau?яxUSZ %&_$|=DeYEN@/,5:uWy%[Ċ+o{'%\1?#Gٳg; '$_d裏x!]ꌗ főOaH  # a@bDcaj˃WZE]]=oɆ 񩧞{沈25_)P~A~֬YqgP ~ozj^Ipf쯡i*Z.K[eC֖ޜ]0kbΜ993f/sWpuqw0a wUnذGy+[oůk&LÉ`ѢEn^|KtD.>o0 H!nhDcN֫Ј3w# q6]vz~KEEf͢Bʸ8p Ȳ?i\wqdӦM;vÇ'}ktKhUߛl;sjy჎[bUI95,bBgPn1B֬DQV\YBd;?OX@_uovyǘ_0ygٺu+wyg;ɓ~rrr)ttZD[Ϙ}G7Ӣζ&ha܈헯@9A8nWWsN6'#z+&//ȲLnn.oߎٳSTTԩS)--傽{c(;U"Z!nƾ#-;;ͼ ]3lOZb\.&Lm=ϲtR̙3<:qD.$}ݔm6v5U L@PoWv8^"Z4M%EiQT5BLu ֶ~W\tC9Y/~6mMZ{1׾|~WGii)6ͻ?3sbRnmy`:BQ\D[&E olN|뤒Ν~F?߹s'LRzqđok_ qx!XrCr:,=["Ù:u*<9ش)[h,+( 0O^n/Y雑灴Z>4Mk6f:++I1ͣi1r ⲴXtҶ`.M8ӗ! xJL 89j֬ Fm./>`̞= F3[~=EEE(† Xn}r~ M">(K]`6a՝ƜJ$YFdYׯ5 rCx_WS&! 9@Lu&q*9z FCp9*bK)˦-Mv,$38EܞYsvZu'CQ ~G4{(r);ӌvAwe9w a[fS2i0Lت ! UR܍*kOٛ0w$g6=ޗ;us@tyMQ<|SWunR@U<v]JPp5ՀGj U3dc=t3nfܓ?_cT-Et U/ 5*4]ETT=Fn֐;<T>JD0E?uتubO_\|B4 \JV6>ৢAdt~S9@"`f ɆH744]*5|+xu?b93} a !r #F,%IݲtT<89f0O= 0`Uh $U_$#-x.Q|^ww2o</^lI2( q$w[O&&LLAy0Y!䕷nғЧ4nh ezKH m,[r=8rW&sJy@ @8fɒ%HvfAN`ҥs=},\k/?L[4:Ƕ8nj'c\u86W<̛33 u[x`߬fnZۙќ&j+ 3|Dm>c-`ߑf$e{0z̚g($)Ȓ(zw:'ջV[$BIbUқqRn%19+]AAߕƕ3cMyßSH*,"7.vq#/,PU%B"dY1ΟV̓YR$]7f r{>2KqS_fWZsנxds߸OX E3t!CfuBZ,XS>\4Iy3n7=aoGR$ 4WO[lBLdYAB2]fM IDATW 5);H0w%SY>]nͻ1GĪ"V2JFx)(OnryLBmt<X7cu Q4d21bZeOM,"Q%E(r80,r2 p!XۍkSE¿i;mc"mjK:Y9q9ul eʆ$I )s2 1?>~9%r&߲8q CgŚx߇9So@׭ʆx-E_6bpiʧ+[@U;?` ?|P?};P<|BᮃS6y/ Wiy_ZZTt93x搂1  w oU W?o3wdۤu`59JM^܍~^oЉiQz6,?s"$wEb$~N3']RTE)~;}, du3H1<1a,Lc\yѭ%h޿9;wnuͻV[wIy3o` b~amE #E]ӮtnA2^=bGaG:0 \醎,ٛ$g6;(.'vYEq1Qvxi7Vz-+!i_$2)pCe8[U.!mDc!5zH$>(]zMA:f#:4E"mۺo oE\}$]RƏpL9M >qv:NvF>'+5Pt R8P/EqqZ0ޭEeMyф59 MVz>AN@s}PH- sduu39+MrO*+ߍhɍ?k7owtS0̭ GM!Fjns>8VHCS\ h4D$",v i{76õaߓ> |,E{|+3z4$ WMk)r>Ѵhp8>OX,‰tcXsH1i%dRY{xM "VI'V~7?c;yCng _ȹ0qlaM9u15lmý%հ= (N4" QMiתfE z|uC#+Ga __ ?ZӜt MдEkp]*p p:eY}-:jXcI%tǂ;EkR#XUtCgb*MB1zLcm ?I}܊Pz֥]C"qLKvMA6{yYM^n_1t,<˿tM~0gծj1'p!\hx?vą찖 v!sM73DjckZȶ%|-tCgӮUVSwNUqjF81#B0mN31v'?ףMWo `ס- fMUߗmk:MW-I.)s =͈%8m\u~NkZ{΀jlrѹl)1 }Ǝ0415y٩}NW ybx:+{mc`^noq'tʸ#j"`[+FZ7 a uNG'NNd]c.7Z٬SӺi L{ήC|҂+ZS4Ml8BtE@i4HF+-Y],}ͤmym g[^9'lt]5#9^j+w]kv&fV0vU7CYLewӫ`14.mPjv=v 4-׉]4&ͺV3B4EgjvusQy9CL;c/o4:nŃfhTTGlB2y]^%7cʸ+8c9Бe<0 "RpdEB5:e_4~b!Rf -GF`~_M,aph =xݾG4<8qDVbk-agiFx00`:0ؼGbP(4M U5$I˒8ypJUOfΥM~cIcS{N#/{(:Fr6nKyRoi/􄞢Կhn+=$nMsi}|ұj&<,IZ*=4IO٪ni7:)D$OnC@S?ڏN%7Y8o9=!_dxK5Kv#If~t>RZ KdgeCvv6"oH1q㔙iZ-e~m%Ѹ3}膖h&ϕؑSI ##KMm%5TTPUSيy4lfkۭ`{K*9"+EvjQvvA0ڧ&ϝ^χ秶*j*$' 92BIC҅hVxqp\[Zƍˇ,˄5=ו){Zu?]CxH-puUԅ WʴqEq4@V"]g<~Kᡧ5)XX]: S?␾)X4 Y1`jJuYџK?ZFw[yCEuh,lKgh-*vXGkzP;1R=v[1~oA|v5j1e\$Si*~t!?qu>}֋IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJB0eX!eX0  UWꪪUUUUUUUUUUUUUUUQUQUUUUUPUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E*U*?TԏjPT"JOjGUMj֪5R5(T#ZjG֤ITU_֪ZH֩?TQZEU#kTjHZ ֤TWZQZ֤R@_I?_j#u֤֫kTQU AA$! @  $  !! HHHB@  $!! bIWWcWW #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???uu$??7Ax@@`O@?Qfv %Fz HDOFиO0apz׺n~ev,ԨK!g-+IۡO< Y œ%=JA? ^}YRSH444 Km]{#qli8v c/ JQz?am"ܦ%u"x#t+/< 0<|[f829hNQ.%5jߪ~*!3i {@ ;o¥bwF:Ue膆iitt什kϽQ,'۱qo]v1le_g3E!z֏ al5D8-&8V(S]H*Qihz2ɴѽl'DZǶ]tqIg!PD%O.ׄ$Z0k;lTB =uu[s3DضgmtwMP[#lqE"* `;005¡(!;L4`6 { LWt:o|F)A3Fl'}NO-wWHlD:N`,hHxQ5`dCQ¡(c*nv>P88{h)z?/E۟8Q> f-qaZK(նF$# E?d^۷qB6.@UT88=֓JR]qllLwT"`9tpl{Z) Xp+4fHؕ> Ju E\` d{}+y,6970 nRן/A8qH(9+پZ@6DZ1y=RƘ wŐ%NW\J$C(a 0-ȹK)>xA7ĈDޔŭŴEk.t#KȢY@r曦F<؞ ϛO8uX!x/ @]s%sl^V2" ~]0h,/+ nBi<"K!jlWPMڹ̢ySTH(E#]UUE-a%-&FЌ0e{FUBxJO`䉆D"q!9~q.Bn yB(pE psKӕ>.gY-LWy> G<σj60n~w e(K V Y{Mu_%J-D(dH¡?lB j|q܋t?O~|+%>%cY:v8ɋ;$?Z|hv'M*=FwA6-YM1-(D¥ )8YYҠҎoFP~/^=)ehX:eD,Uza:mb(.I/TFb1O?w%֒,wDYw\7t@AqRzѳ?zag&Y`59>lB7LA<# QL|&r sqc{>ef^dJhv9-m4^Hewu#?dzQu}ec+\ yk /+>k9묳8~ӭл^θW=ilZ2QJFR PP`D27>T=X%PG!aWv>Xm}ub 6~47p|ڵ߯so\y۷ 6 o:B:USTPY!ςS""SHMo;֤j ,_lя}Г:CR 8).c֭[O|_㷿}cz?&U^6"2*iϪR_=m{s fYU?ء-B('w'ΐUZB*'0mE 6{e^"%'t=ȩSO=U'f"~X S|ј`<ҴU^R)%@ݛJ׶Ȍz+*v[-C(TgҙPjz;?ţ[m8#vђgn?eNW;&Qj$TaÆ ]ni'`rhb R'Oqhd)xHasok<<|_v-WOh?؃_y=H_O[~MHAT RNUް.套?(֑9 Cn DZ# ,n"Ą2y1TּXtu8OQcy{]rKF)p v "&Zsy&[wܾ(!yNV]ikǟ\< oc#-#ҥKK'22!'KXdY`5 Wv|rX}v1O~͈Rjp ]*YG)PP3S(D9o7M !ڻPňi-[|eh#poX%vk3ضb|ZI8xx!jAJmrW_}5t;s2&m t&D=}mr:gR @]>,liR is7 ŨMSzF ?Ȇ:w]@ $OOkU# MʡʰcRd\LAmwF?Qx݅>lYmH)']afp_J]x=QJI^ׄw[ҩI|r[֬q? xANWU}pxeB4)0=#o K\>x80@33r`}c(;jU?֭"-_Unfq> I}@`;QA\I%xxg[l`]qs$~ };Xppg%!<Dkw^ຏ3; ~olkX~5iV- w< Ylm0 7ޑƚ5kҗĘbEuAʯ[n)k{/lίafӅ ^4țOY 9ж  SJH8Fj6+8+Ii2#=ݨ{%ˍիWŭN<ئMG_{aݺu(]w;v71Em!%##.u̔'M"3D7[ǹ˺uF= `@n)/}iļ>o{XlzjæM~65kpgb .B*/"wu]w~*tGs-~ ;|S箻v.gijjoe˖L3<'x"145JzӉo' #QKJӲ"h RQQlՕ'?L2XL*K>nAnذÎ,O>d>ϱ^Murf]YYP^rֵg|,d5-}.F:Օmo*x嗇6aq6nֲJ4{28ԾӋ?^xAHq5E=%ABjdS qEQq^JI~ͯ2{F4Z &F8 XLǭ`(HRTUQUQG:UZ⽪y=y+w'eBAd#KyZ[][.W~w}y~sqˣHpi#&)#O_ ts iz!sǯ;-o="n 5 Uy@U]Oqatd]S#d1f)%yG>u;A4y9) Ɩ: 4s/,chOGZ\u>/n{hLaT:((Rk?ªU\A[ UjbPE̙OuCC-*{fࣝ+@;zc9&c`;T%k_{?PN]#$iޙRc>קy->pz$ҫ9n;?3<'>x`ʕlܸį'@{_{iOW!|oq+qM6:-bk ;Ro/]KK {e$W|yg7nf^y~kw7rJZZZ~P78AXllp8ʽ?cjK!8i %?vc%OOO35 ZDtx.N:N8ag_~9p,v]c|ܹ' /}Dzex{ 0p---L# u6o}w{?ᣗkHC;}iQHu3YL 3mx&,z? BSSf͢[~38pеatM>|Gc6'l2RgmmmeC͍7,וT6RY1)%ϱh"lfӦM|[f K,!SgժUtvvr)V,w T@u]m=`QmmEƓO>I:F׿!ر0ؾ}] ˲L/(hEE2@l4u`0Z~Ԏ!DrEseΒ- ϔ3dlS$|=`粡Ppൣ_\pz/{i9PncSN΍]bͯ 3}bd@=Nˠ!o; 9ؾ#!#x<^O~z#:#P=WM[WyAL8FQ&:BQh.#H7VVfomD czFxyl@P"T%PPyAakG8ˁ_JMg<o߾]Uv.!bPXŒ~zI׆Uj<~G8!RH N>㒼eNb6o/M(ϑ8&yk渑%e8IU9'RsLLCH/Ѐa/0%MBaDTVNY֐bjO%ںN꼁r&!䩪k@\VW6bٮ-L!NYrsg.AQT[}5}҄1iȏGs;'ZT|E#GQ\"ܭ!l۱@RtV EbƪL&Z|}Mg:{JO_U>6JіYS ◹F*M!hvL,$!C62ӥ@ %:w ^تZꪏCJIGρ ,J/~j[ io/A&׍nd$3\ LIDAT/@Ga覆7|׋9+QJ[^?bDέXH~.%^!1R g2!q\CQ/Ug”s~m9 $l2kD@^ϐH-<x_A݂e[#TG}NRfT5{h) dw޽oă !OXmT$҄cc:YU 'z{l5MI‰ Bx慼ޏn04y u /w"jYH$\H ގ-(\XH) !צgaT5!Nt3Ϣ~z3tưtxӻ#mG([wiiC:?+N5leEhڹk'ȩ+IR„exAAQTLS#N9vvH8퀬+M.Ͽs7Y*@ Y 3fr=TY7$T! G"ḯ'Hz{20-1iIݴuCDQXÏoEIͧqRigZW]p I-?%]}:⏇"n0odm){z7<{D %ҳYm}pI$3,97,tsN";o+,E:HT$ %6GA8YHGAXꮧ2D>^4*n|w3OGNW*dr=T$?~H`o+tlsP9pM1C\.&@0Vss{ O ޵3 f/*QKe *3H&Hƫoc_xFC&M*Y  Rխj,F).wԞ&v rd h%PY {U"(kf]3XJɠ%k8EUTڹ E y 1L EQWrZK] 3O4jŠwW Gz^o !Lx@?πm"kelj 7i)(Bucq2*53HI+IR$c){ϝhzyiTƕ@Hr*]d{1,cD#q3돧s7] ǐH/e>p(BH c;&]c܍,'tSö-"N/:?@8 3^x9`q4}t#m[XWwJuhvbn #I!5L"r&@D#qHMu]͟Bod"MEҩ^Jd-Axnq5-WzU83tfKiJ8'p8g5und1BB 23Ӥ c#[=e`>$OxԦmyz o9ԧUФRyJ9MK@:!5 RxY1sJKa4 iWIENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBy0eX!eX.  UUꪪUUUUUUQUQUUUUUPUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkURQQ*֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjUQDT(HjZU5GU$GTkRO֫QDkZRR?֩?֠/uU$ԏUMjUR5(Z  HBB AA@BBA$$$! @AHBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU *R Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???nn$???E@O@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5$PNG  IHDRc IDATxy\W}?UZ[.,۲%[&g8aĄ K89@f&pxfl<b9d1ɶZ%Zj{ޫVKUWNz}O @Qh]` D$#JIH堤QR:( D*RP0B2=\ܻcƛP@`O 4 R'QJ(h"kEkm7@ʌ00r`.WT4y@H)p@`'Cg%QY+C4/H;j@!`x^IA[sD)Ƕ};8rh¼.%P `0pk֭QJaZiy;sAE[!e LM23'miwBJ1gi{ 0 96+,T,yl%SnRF%#b\NEb-0SvLw;Α{S™q[¡*@J粟a"ɳri;hsi+=Bע]ė*wADYYk!Jݴ)1Xv1 BwA#'_j_R(.hG~6Kj(x;wM<[߆)L+ieZ_ ]%im!;pF cTyhh;_nH)ټf$.m]m(%1 iU 1؎E0'μ΃[Cvv>%q~w'(%9ر`jgmlZ)ft&I&3FLQʦ;_"Mb&R:$\#^S3肥qB! JB{nmc!!#k鱃#mfR4oVHgnw0m0dz=3|Yp'r*yV/B86X0R/rJ艝o~}<*6L$7 5;vl̦gGZ'Q76A ȳeCѫ*GSiFaղkXPjM b.+oBi%tx_4n6*?ZRMtp>9vTݶMR@^7}.ߤ* kr1<ΗH1 Y+U;xjدxu+nCi` B?ϼ?9B +_g72f臘?v;y #ZE0 iwr7J*V<< P!&QP5"߻s:{lqlBJF7_/D׫>t?2 &h8Aǟq¶Y_)mbI<2[F xc*+'o'+{T"i[n1lͷ7S|7NGJ:N_CYd\.f6kw1<֋e8v_ccC\9,"/:\<F㟎wӚ[Xظ^G˘)fLaZiw9pxMN+)$GsΗ8bma 뗓1ݰ3IL19DLTS4ֵ^|h+O>$ <+nucdIIm=8C+c`[4駟 pr|?{)\jiIygŀz#xot<.u]{nᇡ'In6Xz^9+dgoP Uq?h[W[cg:9*IjxWRGu‘xM^gXrnVǃr t'PF~'y LsTyi;e[@/N; ~8uzqظ7Bak(T.d\W,Ow^~9EK6 :3YuܹEBg(TW`BLK[mK݄9uQuf-)캎nqy.wլ{={sT6BLzvc,wE<:8JVB2Px Ac'><ἵfp $!5q@Fcɂ^ie, ZINߧ(S2# CQ^:, u]|++4uGHi_]h  EEk&%SO=ӧ'>Q YO]v_ے!a9lnAN]444OsB t<-Dϋ<rPXvc!,Ǣ*`;{y¡Cعs'RJo9sBP}Cg?O4.{JܲCWL8hyWa%}C]8f$9Xj*gƻ׌"{G'?ɕܻw/?yKزA,BW:Âe&E;N(~/_q` FYqU8Q8ԁb4(```'NL7N'^9xX4AFcd<(jKU$b4>B$RjNAPoUȿ/|| `07PrJ9 N}o&NnpR6iHT7XP o l;֤]R%H%O$?_SL6gN QOUq۱fr[ȁsu~G}Ӵ'H7(E*={, u=-+S%v²,?7 yϞ={xꩧW o7.t10 Bʌc V]&@F,#Qoec8]c쳹: [ߎaXejܔzlc2o5&ת c3:ɺX%l3]zw}lڴ$ڳg/"_җ.'Ozt)k@@>'(|(WEuT`Mu[ '￟O}S[#7 mmpqñi40^g.X/'ysGڌxˆ<ϊ+Fgw`tM䣾f"vRUGb49P,'LA5-VMuKԺ75˯9ͪ6@ƛTMIc%~]j!pQi7 bhg-L&?I>׳e-Ͼٟ(l07\3'C!Κײ:Cc'-6.KSkD|햌200?Er]e9CZ<\ؼ jeNQRl$XI0G uMv=p 7PWW?KzA2`b@`H%ߍ] ȾAxui[>fFl߾m۶'?)]P,7?FOMZ~[լO{5װa = s^{`mu]l&NsHqj7U<+8~{!^kȣƕ7Qi5BPX,Ɔ r8`Bisa@`0H$aҤ3u> O97o+0^;Bx @@xq8x ˗/7{y|[ߚ9=7l;xfSG ;!k֬)*֑~s&G`_HX0U0 w8'rK\?Xr}oAηyP(캾]Wq\nv^%K꺴DZ9`q/45=p<(ߘ}8|As5 jkTFM@qtʇrD:"@W9woO?H1%z+r# lc"i;]IbYvokߕo,8`6m8S#d$ cA@} 5 mvF>Y&* Ͻz%I ^ry_hA?'(=)t`ó8>Wb6$dwc/Hdq , {U*2ftvTf۱  51 \5bfa8X5!p(3E*=B*3RR~9Õ+ Z,]T ܢUKIT7Ro0b.ݻioo_2ЇB`&lT*E:0 jkk1M_ʙo{pqͻHgǐ#(qesq+mӚ&ܱ CsR++ƃz]yzy;[6B x񵽳nK B|x3Tf%D"1JI^;|AQ*\RyUsnƺ cAl#mGGK~w;2lmu))yZU+.RnP$ m,qpQR5SKn618r%=;R+λuS/[66BH:3 qZ,rsEEҎ/zJ߾~T1N4W@8s/$m3xSw7^>/n葉m!  0)bX)8y6̧%4!%Q/@EO404qͮ;Ƴ?0}TE(Zi~Ҟ"_v;я`Pa2{׭ХNW̮A#H"`,=h-¡`Mkvб enjhZڙ)E.w4-}Sor!0 oy]=G9{dfQ7o$Hrtf)6\u㶭A4\MbYxʟa')/xut6eg@Kq d0(R9qkXFSRf,5+s_y+B) (K` JIDATnKJ'W@:;J&'ܸ.Ryh`uf]HJi Ffݭ״ Z)2f.'Dn-hrWB(#At.hsLҙ1ZWX$M$8}A+>RӞAdS$$b $bug~o^ƺz)Ț)1z~}%xb> mO{ۗlΎRI`gҡ*RM8\ŝ7)Rں*~E[KmIaG{8s4s :S'$41:6ɘ1"q"*FRf1l +_[u'4JBdzXf|A)I:;F*3J4@!Xv6ZڡheFq@-Nۙ %]UIq,- ,Z/p3%G:0 (n2[8y \rQ22TEnLZ \IB B1ɓՙfEIc 5ۅC$ AAE},GP[ UVzh~yU(zrpY.rez_NU~)eeUQJ2S,9y#P !T tJegk\\u׳)}/ nI~Xʂ<0@yHIlrrYW0MK.ǵ:-w.9G~(yJ$ez1VL׷OrU(47,oaa]@OX<($Px45c4ԶG,y_>4΃ś;&׋)R*'x"/8Q݈?`x$kMT(4 .DKUy]<?hDҚ;w הT7QeI|TE%97 .DuU-5MbM(| eyD@ LDuR乂١_N5r*kڢ\Lf"&OE )yK~Ntb[Yߚ]<1jc?(M1IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBr0eX!eX,  UUUWUUWUUUUTUEUETUUUUU@UUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#_֩?H֩?֠/uU$*ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩TPI֩?ZEjIHZZUTR?U5GKW[H֨?j @ $!! HB@AA HA@BBAA! HBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU*UUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???nn$??@B@tG@E@@? X? X? 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HBB  HHB@ $  HBBbPWWBWtWWf#UUUUUUUUUUUUUJUUUUUUUUUUUUUUUU%UUUUUUUUUUUUUUUU$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???sMEs$???=@AD@?า?า?า??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 95)PNG  IHDRc IDATxy\U=c;N:HIH"P8rdp9NȠs"##*A BȜt=Uݝ֛g_o}[ *ʦ].ovm6N_"k,Hq /fFB SwbǾ]&O y)3ƀ$~>8V3"I-`⑐HbHeNw|e\fʗ7*47]-y+3GQ$ y)jl[4$|x2BHq~_)dJEcM3itS( HȲ GmUe"I!)yoOT\;/]rTWց,8xd^Wi^Ϥ< QH4.N݂I!0M! $IhǞ0SwD5>zWy;r*S}׃%'xgQܪ7Ifo+/> gFq"BBlmW5QS1 KXXeiJj$x'tېL*qqi4Ս,HdEF44Mp;8ܺmy_~G1LcLj#I2wycZo wO}o\/nu~QNewbJ~! 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D&ؿ@S'#jj ŦokM4N}7˺Oo^hk>w #;@JΚw;i7k vgNGRi>Em>}A7lb.?$c{x+K*2\~OȈtR$8jb M@ҩ䊽ag P0̈́䦌 {Pzi\+#smm;t Sڼ#ۭp$l]HQ<,[xeIN!lǙE*ݯ%k.G ]kƦ}B涘QOZ-TvLM ]R4"ٹw~勮⥷ + 3,~X!_ i '#H$A`PV$%#C9|b7ntp'پ5+hx7cCՒē9ȵf vk9qhd㮟aƑ=i9O/'-SS$r!pc&-PSPaV[Na>8ڹZ6jq+⯘p'׫)v~nV$ .m*<`eywAıic'R=ښPff`+YRqaΌ4G}q`Y<_w*} 6)F6%5pk%Õa!?<@0jޠu<`_* :o9 .R_GvMuSd%z(^~Wkb蚓 TvTǞ?9l`!yK>c]<6 yi2iާ\I)WQS9,s>? ~؇ܴ9;Ƚ'_i5?PLRVUxͪ '#0!|~Vwne|2uD"D0R\U-vtCG=w@Ptd }IDATZu>G$9 d:-vHcڥ&]x f4H4-a bՌ)+[~iii޵U 4N C}X;JL 00N${/U0䌠S>ıŔNQ0ׇζHRjœi s赋*}3n?/ Qc )BD2olΜMϿXPîP<~6eIldf@zyۭıaNNE$W'?#!Ό)KHw_qˊkG/ibChu5ݚtU8TSS;,{cU%`EHa` B1R`XVUw,WSU/{㘩(֞"۬1kd*FRK6Լ?JW#m؆5+HCgs{~+0cGվptg LɘsTn.Gw Vj",x&LHfEu!%=G#5̜ڻ;bֲhHg/njT;|{E$ո- bռsc|ç696E:@%o+IPd޺ӛh[(Xq A.kesz1ZS_3F4-^ؐHpI޼̽ҒE1_a9SM&R1eӾC.QԐyiPX32IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBr0eX!eX,  ꪿UU_UUUUTUEUETUUUUU@UUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?JHZZ*U_R?UMjR֨?#jGUT֩TPI֩?ZEjIHZZUTR?U5GKW[H֨?j @ $!! HB@AA HA@BBAA! HBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUURUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???˂$??@߯6=@@3@?#?#?#??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 118PNG  IHDRc IDATxw\e?L^nzB$y4prU"zEEEE.]B HO6ْ)2;M|u9ywy*<`ģ%I@(+) q) Kر] B?^oט;dN_x yWK!pN{t>nop YΟ9XJ +\=Ң1 S.&hlݕ}-,,4 ĴM,a!JU%eȲC"iH.;$=Hv" S1>w7+Gl۳XĒ|rB(FU@ ۲LO [&oEd_!_;~CPDEQeI)?bu!m{ouLkޞX (J`Xׄ<ΒtlBgMbƄ3T=$^ii'/iB})_=okc-ҳnrD(Ba_S}`wN=77Qlbl&'C[ v սÜhl X|gyeG, /"I2-{e`<;H9H;z#jO%uA"g]Q@L4߷H,\tgxjկ2W( J(ZY% aZ&D˰7/_.9f-+})m$uL>ta/anϵ.(e0|bn7ܥy:Hwfz2Z{8L&k,yD-Hަٷ *U7柯)hr7}a1L $]|9y!ne[,}# 2<0lxKڼmfO9:ƫ]v;ϯ3`T1/ȉ<'-GjtvD$HFJg ֱ//I/nL726o)4wԱy aM >i!¶Yzx|Q t-{BdB'-^!>e˶-lIJM繰>w~`I 83ajKoq{oe;&-`J9bx뛷:dҸ9XctojV #e)ļ0g lP?aarD̩=-Wu~ IgbȊBAS^Ya=ݖm[X$H*1m÷ض͟?g{ s&hF'i_ђ3oL KG "K `*B0b2@eG~4,+tSS_04I!Ӱѱn.dIFH}[=l2 LKsVݶMJKk" w=laWr{~ȣkq]1987+L(*l !"+l[kl2]2R``$5s(45bZM,h @YRVwC(.UPC$qS/$NO Om ׃,.:3Cp1Eevwys.hEmb:ac:k63M?𖻿<|}4b񟠤^xXӀ㕗TSXPB0$Ѯ]ִG5H0FU^ K*(E%,"  $)F5n/ɗaə7pU뇾M.zCw_-aRYR.]GK[Vxs]o]@l]=Ochedegc/5,ݲBYXp9=)& NStƛ{s{!`‚b"*Jj({⽭+3D8XyK,KD͘4 Tk䚹8$a 'ȀdddYo~sݲ{5'!$uYz\_%Hn]Um, *M<֝֌y焫% 2T-ijdU R) OO[|oɲ!g!p :7G='m򯤰Ң1]KXwGBSn\/kS/&Uw6U3_N lHMO),ˤu'UPdUQ)TPY:H9i- o'ώ鼓Z$~.GeF}랓qսHX״qN\DcWd裿 aO!I2KXXd:glK"piZ:BؔUϲioD7)/y$!/v2#SE[|E]N܉ xCCۿf`l) mbVV_ M3qlX==,̶ۤMOG8p={=p]Y] !Nk_&/88[ahA,Fϱ-}1aLWNсȋcԱKXr,ol|\jDQ߼ f:Qrڟtq+EUԌmVFVLJj?ȋMFn72om;ɝ8]aZ]%,$h>$N5c2~4p=Eg|B({%yN9z)TU埯ePy!(/L^{q__Vꃃvf]솀xOضͻ[_bԓ))w"?iM?U DU¨JEUQU[Κ]9}gjk湁TnqK>(! uJYvBcb qZCgSRXNvnZ ̿rFҜ' Ϫ*c-uߒ۶a85;_@W)oL_x:k_o8p.=T%$ѳykqpÎ렡ƏB3vog‚ӝ%L<7ˢh '-$'_5 ihθ)SHoսî}O[Z+rZOвlvᄍzlOQ  P' Ofӳn.Wy)+uԋ8 N5Y)(pm6fΜx/%գGO]X  э.E6lEEn$i EL13㝞!'ٸ5w"߯$Io1ĴM[n!  |;=HQlFUU0GuTy*G(=ضw/~tK_h6c':W.y!+I2ѓlJrG^|E***/3ӾEQ0M˲0M4u"}N gՁ%,ɣCCҏudܱ )=Y9=~7޳+V0 XWR‚Xl,; 躎iiJ(8pCa8UR]bID en˃kݎnF!Rl^lt&N*uT]9t"r\~|_RO>HXNtwA&!ɐN{=2 Td2;`Yܓ(mJO.BژuR%\ߩL= 88v,=nj$XBPU6zTU%c)Zr(s<{#tw}4MRT_ǔ IDEQHR9X6v}ݍG-ѫ%A@_ww{혹v^Ld*ז\-%ըʟug?K~>ً ,"L6O2ڶ/cN@RyHػ#Oא$:/17I5ԕ㸗OXMSG32G?6w^lBCC= x }t8Ȓ@ضM"^3;0uP(D0tʾޣiX%쌑\vȲB}n%o0TԎqcNw~ʾu{[1,pֿ#WnN.9bnUW_~51KNEu8[x$I{G?:iy- YRhj~l  qN8 &$ Y}{CS]-ԧ;$Zǎ.eN Jdjz0S@*yN:$ضc=F<+I P #e9M˲–=QaJ&ű%^ q-p91i!,aer9ˈ]U<g>sʱn%'W߾;$\ (ԝq*u#g}֗3o<-[FYYO D"jjjشߙlZ/%ym<N8IKs@l}<=в-Ld嚇x?&VK#p0AC֗g}7Z3<x~EAUU %%%[huȦ'#[%oZLＹI[C]^k|O;Wu%[2i<ϟ?>9>qqtU OIX>ty'xñ,ߺ=gUU),,䩧Eʰ[ܵ܎|K$v톢2'^n~3$cGq-;2 Tɢ2?ʹ g[-쳼} D$K=jd$ɄaEc8tՆ}c0 m(o< !cƌsL5hucV*}zm8u]6^]94<2R8{ J}`'s y["̚:7VnQ^?E'|%g~Y}`sEa*^TD0o;Ip8sKx2M3BQUw8ݰ}5oeMS1g?a#!(*(eތUMz!q,xzz>_9sӟ4WwD:&Lvimm6ZZZhmm8k INM^VAT9%M?)5s1m?>=m4˩_~[vi4qcqoyB3oӨ*HUx~f=>߻ꪫkQ:HŋsI_,˞4M8oy$*Kj=b2߾OAݹөf!E]~8 ^y_'[Q6|2zDHـpofV\r%\:x'YxL$Lʲ<7!V@ QVT-yEm[yNyWxǹzgZ]w]o{7'_3fp-qch8}:rݟCp#]x! |I`NI$N<'Hi|_ȳrw8Rɉ #;v3{۶o/ywͼyꪫxu'U߭qk_iUՁCOR>, ²,?۞?lM 6P%d$BdY4G.{t˖-,XSN9gptM6!-A]t.[[t~3b N:#"`We"K}{&Ew\(Xn:Jέlqqlsm\z>AՑ6%Npw*/PF^cZ]!͡x,0imdz I um@d \pF<B}=@$\BQ1PL|б@=o;Wã'aF=qy_"э,BC )w4X{֒7oYScR JJiht&EH E( c u[^֭[ǥKAdY!(mGyK.$sڥc n\p~Fyy%e$Rܳ֎}G'E#O*c7PS5 EQޚ7R߼ uaLt$5hjǞ}[z2hlt(_|qcez)..fD"^|?Q ĝ`4-Ngl?mƞ %qaD$Ghd&lEUT#!1kʱL0D2lvcG(!%4p}?!7tS/tOۼu򕯰tRXj-q˹Yd ʗnGG ˿}]Ԉ:Hc$RFXN?w?UQV<)1qD,auF־?8%YR()$eԼ[ַ~;#ز->l^xap/~>Y.(A,$2qcMv6e~8㠒(R,cq vmij ea_[~y>q¢ExEe@U ]$HkqVMueصEYnFC^s@   (PPP@SK= M{xo[p_)._`AT5H[[5y>9O@ PC1b6ҙ)q Pz6*|c}x4y;eIfbfƱrZdUFnd*AGhlʹჱ&&lD]]*̓KQ_ҏm3h#D+mF!n]=W^y2\pAsfR\TEE72~L<َf-Z"9cdYAQT9 uIe(BQ9' k+JjPN$o6~ӟrYgK/8׿5wnܪLrCKe+z-yuvDHA ő ^YȐ=#_ÑG~//c</<"+ tx}h#ec1LpU 0cBוgS4;qv{ϟ~iزe = vL"ɜ W^y.na-dI!Iţǚ^ZqEIVT' [@[Ώ=m+k:K/woͅ^9SODNHPyneIRC=z(Bm'#~31HOukbYcNiIaCi6L41p׾26d yhz7`v @0ؿ`7. (  `Zӡ7͹XvV6_e%L 26 pg;gv@U~0܌vH6ݻKذa֬`BQTdIFY<;|s|'û~H$̙8e|bP^^}Wy{ٲؼѯ'I PdIs|韡 s.l![4QYș8'-]7=/F ~Ȳwdo@ OrC9^CC G)|ɣA2$f<9Uˌ4-;xu$Ƀ䓧R_#&Ldxyznv߻=toLjZuӦM`„[t⠆dNp BAj)2b BXd{7#ou<˒9p ( }vҹ3Yh$Is>y;FA.:3L;OHܱwmN~;he'@oo CEb [E_r%*{@|%9'^"yx㗜qUS4vկ3Vz(X62' M-̛w=<_g10PGr'я;9y%c m!JIV ՍFQd'LG&[xbe}snL4#M:=m=gY71b #Mgw0/xm-w WP^ޖx̘1ϞM&c _| l#s9N/'Zv Lօ_l/ͻEAQ~,aT5$Ivܲtk'߫fi6 i{.wt`4 ,[v4=ֻpp `,pD^GA犏|U (*F72MAtؾG Mu[*B>ZB".\b)T5z]2!ŷu3&ۈ';^r0v&=c/nv8g8#xAmկ8HL"A*'мƲM~Ɏ0cBwiSzq?$lӸԒs᩟|`E@ƀYz֍LDXm2P=fBؤ1yO8UWҸHjj]>r5 I[FL^]B4#/exp1|`s Amu(|₯S.F2l۳Mc۷祗qGdLS'٘%p}Jt#M]f^{/^Cܳ?ͬrEV c⳿@ex4=Mc.^Xj@7;(cf<$TCJ{a3MOY_=r-ͬX$DZh}`Y72r 3+g4*x<ػZW@ӄ 9|s7d8p$5b&89T\~mUbNmuHK/]KRVV~Kl$}wAQATc+'RuHm3LS.ܨp9~GAEΚr*k=u!cg ]v;Er2nh ;X7bd00#BM4N;#$)~όߧ MK֒ǚhh9D0g3cԣinnW7>'|J S#%&Z׼rΌ Є@44Mؓ(/=Ht:u]T8v%DsL^9oη(IQQ1B44Uuz\ ev~ǘ4!4!a PRH4ԧ}7Ehh:dwسwy½ECBaV kvqtet,<»%/l*gxD'T\8$0U#%FJ%D"фDR]~/ p'bsy,y?}ysaI4 CaVںTc#\)nfE݈X"@H a3 )@(vAEHDdۦkP9چ}؎E,L~މiu]3u3ML3{MS0 0ճ5Tvj모2lRAJӅںq\\X8͊w1ZMqAI =uH@Gֿ$ғD7)ɄdXXoKq\K,DKp!3B#dF00n`&n&C8" 0 %JC}-Qhhh5ulÎBJڕK+wu!hSƟ7}:1#'CzJxJG'ē)Ww5T*gxxTm6l_$8D3͡Ft L#LC$iU*Gѱ--QZb$ h H;hB M:vFc ȓFB ty'ȳv=DN9W}[#kFkc=Ia^'Q6ҷtR齮m,k_9hK=Թh޵uMӕ@"hRJƶXN Vux>Mu<8%#w.c.n~[5s_ ȣ1cH)d+!ĕ  0̑{]S Ψi铨k:w'4MnS״Ve>O>J%$vy8bQ{J8$$f/SAkwji:A4~cі:c 4i5o"KD]#V}d TT*qİɽC3t]x$y$O2yR4si7ri7ݍB]r?i*oA7\G> ^xȷ9jp(? |p% ţ pİɘfAux_<&nzS68O@HNw5)>u/wyһor:aY\r[w>"Jl'n:{C'a!<:m~;} x.#+&$ S "Ԟw5ޖg;Jix> 4:]HuGTT=ʻ6vG aGa&̅OBfC7BCJIsqUM?|9jtC4Xu⌬Фtq\._#z Qhlؾ:Byz6|q#Qߓ4Hz?O1,_ 锩.vxU(tK)ЄCJB .lgk y =a*%TNIK)m1#i,_d31|8 ^mى~7GO24Mg?)yi1,Mk{wS B>b>[iC!#DXF4~a 4 8j.Bl )@PW %onZ6NhrEu%# t qA@A^IjwR^ZI4VY?#ܟxi$Zw#s^gv\;,… ٵkWS6vy N5;݁eh5\Kchx-( ;ei @oٰ}S' \stRϟkƺu_9oE}٦<81صgX]@.l'RKCS5 jkUex|IfV*hX4Fk5t"Ȋ"EqW2mڴ?I&1c &L@(ǥnWNO{2#mR 쿤=-:F8xtmdrU9(tMǕMĬ(ybon#Hlٲe,[4nfFszeZ6&yݍ^ K.ff HxD3Bӻ&eU޵z"Kˎc;VNر>_~ϟ|~z?nEvi$cu\eL{\Koaoxh6b8*WXv Y+Wr}|r&O̷8K.`Ŋյzzqaޠ&7i䮑|0mu}rQ*MõU^BFܟ'"9s活W\حNpWiv$TPrOS3~t&T@"DNgݺu}ف?r @ɣ#i'|h{%ϸ0rql8Nǵ8P׳~/fͬZ\?{NYVٳ_Y-ydY6?X4MHcYq,;eDZJl3׿#p*_}VX?ee7CBi6ŲcSRTNqa9'Ǝ8X87k#K"тiFBy ]yg )//jߦ7J=W)*RBu0UmþY8Bzw,8rT{kU= yz@=p@y|_?<5]llEˊcĭU;ӜD~* i ;#^3^x!sŕCPY[tp\ u]+0`VI)GػW9^{6}_g̙ԨJYY?---=x{0;:=@ڦU8`e[v4/bk4#,qmc=ڵkihh`Νy{q`|8w_=a|s9iӦi&x1w\{9}]&On[xoQiX"jyi0{)yrgK/[o!C_fÆ ]ƱI:C7l^t;YT]Jf.!+% |~q_=mI/p6(R iLpJ??د9Qz 6_}lۦWZҾK_.̤?Cj Mu9s n\}޸qc!衇:=u]x+** 6gpU'G=VN7lf}.c{f OBN=?̱q׶r(O 3HRv87Bn}"EoK8~9̞z}.ҕRjR B//@㏹#Ls~ ^s1i7z:iʍg1\V5{y~NF탋 )`z~uRQQW\izof6-Xŋ/Oؽ{wv&-ï-;QE@F+D5Y$z_M~ AzP5 tIx}IqEÕ63m%D:W/]M?ŋ8յk..2.`ɓ'~Njv_5.JuqSØFH82Ϳʾ?M>4S]+PM"5;MSF7G?xꩧ2e <eq'pB^y%Ynɒ%TUUR>/3f~Yg5k8Uʤ)@yxǺz2R[^OBi_hpt%3r,=駟 _BRJuCA|UWcGJEFoQ~)b5; iEre3@ès`dM7D,# uT/km"E^ bu8kοp3`\ՏGLdczt>g?|5oQ\BG* GQ`Y\P&GJ9d(YV2}1k,yn;裏^zK/K.\barŊl\pA_*g<=NF'!TTju<޽&͛;]wE4eڴiԤ9CUUׯSO=:c9S[o0 JKKYrBs/&WkգzB mkd|d# ?R#LT:u**ZU[ˣ>1ƍGEEՔ0h JJJ(,,#dyDy}޿dxNy9;}cā h5%*B˹ ֮]Rw7ofm>KBrJs$gf͚5 rn'ؖD}3f!3ܣā %y%p'.\m,ȏ[jrb2am;@분I&?M*[lq!kS9ty6Xsāl%n?pDY+beEoY *%D8ڍo92"hN~_ڈG]5q_-8M8/py䅋xh 7|ݖhFGdmBHl&RoC:eƿıxh 7,q C1x"E}ت.Cuzl~Nͥ0oc( MY:=uHɺ Az*m@ =~JiC7Z Bf]7IDAT󂎽ݰC$ؿm{)b^ֳc҂ 5[*k}pI)A3k:ceS^ZaAI)tѸZNw3߯k#tT8+x_T @s"^{=`M8RvFr`PQ7!F:lbZ<݄.>‹Ͻ   j7Jhy!4 y!q,cvAJX͇_ 2Gy!^Kûy_MiabYђ z Ztd?ɴ#OWd cr0D~(d/W Zkן=0 y_-j'h-«LK OiJh;NX<ҚI5Mt- %'"7]hzx86we&|9̹H+TS6! <"aAA`ذÆ)-6BS,2 eő4C5sL<&;H=`0wfW/ mp].yȏTXWFP D3nB ;۫ng3BI Og0 ו-ck1B!¦$rgAZ’CY}X=tMM&lHmgEӅP.r<P;Bl#ެJO#Mu%a.8u-47%݉/V6v0. UcYi:+\2rj')xM9r_IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBn0eX!eX-  ꪪUUUUTUEUETUUUUU@UUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HQUEJ*UEUjZkTjETU_R?ZHVժjOI(oUOjG'Z֪R?Z_jjFEUWAA! HBB  HHB@ $  HBBb:Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???qq$??`9 @*@$E@?@$۳?@$۳?@$۳??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13|'PNG  IHDRc IDATxy|\C $WHE@VJ+xԫ۪_uvmmnink-UsVQQpcfI2I wc2?@A @9_w>7=d0ut2H'|3ܓA1Y2Hd02 adȓAȐ'!(>->O(?4R"a4o2E12]qRGJz yF֯{)$/&i Η+ǥ?y䖵 yF֯{OiA0{`ɼk M/{vWq};֯onV`m" ծƐϾCꯚODXR`<<ȟjSY6˔?Bp0/_{4/SB]>B>j UOwHiqXLPc)aq&/E(.nǐ@Uٖ!O:㞵AJ B s =gwP2f""袷n}|xϐ'i*QΪZHvV>gymGw 6C4 1#nM/ IMWDǿy`OnVtyc4֓7q #yB34V/߿x{>~B PPNgO }z:smXtG4vO6=lrcfQK躊aSm3vL9G1w%h:q3Z?lJƔ[kD s6d<J"Cqkh`n)u[d$_$HCra׈-N@EG>#yFv|şMkhZ\8cqːg rٺb޿l:G>>j?n<-ٹo AªE z/P. =v4X$J2:(@0{"V.ᄍ"%Sa5+RwW_Iu3V c{ijޜ'f\QRJ']n @p@XueB(]\yT\INm5sA8&! ^lSl|onla82Rr83L:ֲe+ΒeI yR8=0e≶U,.$T u?v$,L?xΞS-۞N HaH")*(EJPqj 4ƑN,[ ϭf&?Řq %MmGOneddnE#l9yc;yaVgɒR3BNNTVV"{ﺑsږ(.,sX`&΍;v?ʬ)ĭ6qECfEC:b¥Nā yM2e f Rhy@`w3 CCCmχB<O(n4Lc9|T,f@ݬXd"~& :OQ?44(.ƍ̉̚/Za4:VBbfMԀc ;vkIz6q|q0ΞS ̥^~oib\Q]m=#3)gqP+ĐBU4]um9uT)Ƅ5{"zTUXd9ʅz.œR=$N_;ye_񺺢.mEմt "! IWJI^^oH W!72KEI/=HiЗĉjtIZ<œ'ƐtT t6i>Pt<.)g󆯽>>^Ovآ,,#P7r-jFQGf1ѭ]L1歸{o(F]zҊ~[hƝ,"d- nW EI2b)_3_L }_Koo/n5SsuNL%l QYQ\XKq[KkҥKy7Xd |F>Bۿ o^[_ЀASU\z|Bgy0۷3B(NdcÐ:2t ]x7Yp!eeeʼ ?&O~}q`/km"ݰaC3f`…g?vwl੧}{[#16)`[I<>`߄/g0I{QCi(#77ym3/,Xƍٜ K恿:ycq;9EC8шHZk|F9~ϟ/cw$._Ɓ;'6涣9܀Yp3Fuֱ~vAe,5}8l{ /pc-}˖-㍜ᅫȟ Yc b10xŅ7Cl#Fue%T!\6mb3=aةL݊+ظq#ڀf́G.3ܾov8`J`ȏD_l!j!rӋ<G#J6x(͛wʕ+_q1pyǃ`OH %\P${u5tVq\o+;|>馛XlY55~MZyf4.Op`<صr6$f`kEXP3o;{P(7M CPץ^͛a *qytౝfTҋ<]hU0k~#~pGYSٷo'NC~~>EEE)]kBP]Y\X{2B4=D ؓ8AZR7mmљeՋv@_Id|&Y՗~S!-q܎ݜT_GFx'|jj|"obdS y3̘!i@:W.+@aV"5.EQRߣ4<%x|Hi[ϟCJˌWqb|inA0O qlx,W09  CKx'8fN c^<=<> 뮻x2cjd29F#MW̵4|8q'M^nAz/[(7O믿()M.RƏ 呛nw_MO,[O1Q@;k֬0s=\Fws=7lEeaߗ!M]M3nf=ìcHSd"a%Z4֣jAr b쳖N xYx=Yx=d?CjC~:{[iMog7?Omm-uځYrJ4MCUM|{V GJQcctp^^sphj̬d+R.)%Ņ,͹t;0tqEcV0{8~MbvJz:)"˗G/';ql@0LC}tIoVID, kYf~플|rJ 4{WZx؏1P\8+c*E’'HG*ՆKs0j/v{p+n <\#in>BjM FIZHk b:vZZZZkRF-[pUW~Y)&Q PZ&w5QTPFX vwֵ/~VȤNF瞊/il3 p)˩duGlvp޳@ :lx$/$y 쏮Z: O& Xi?u<~e%VyDnv!.'?xCuP+LuIH>3iq. fS>~:Joi]0qܴőy>v9yyVD8b0=1bϔBA9@"1QP '/Coȉ RLê$)dzP?xRdJL*!ۗBqm7ɨ hZeW9QQ:캓gRq=y Q"yz:iAt];ÿ+9oA.~/)~RL``&ABuż=]:_s6 Zy6Nz$ ?GwŢ1T8WicJ( Ue|$ ƆC# w)Q#y4-R2ϞYUqaB.ֳ<ˡ*qތe{ؾ7VS4?ږDs<`Fqyẓdv^~ɳ=a)} Ʊ}+9Y`ZܿÙiE"TT JSN/yn.W -mœjf]T=Bx=,$لɘ˳3t 5*nōDIi`suP׀]?1昒Y(…jıa)<]f,_I!}#$7SxվaӘ'ȄuH{^s242AEZ.[3τ݆j?D~2j!T5T#k= in ˛;DD^67IDATY˭Dj~~+ݖq %O͔EH$'8~|龩C/ibb04! 'ɱ~c;MeVĨx&%a_ť dt_#F)x6䩙;lmdHG9q"Tđ膆Kq;+{,UWo+yc# n /g !5"z:o4҂<6qڻB8! )ϛ3 qFHe)vBq d;<d-#FaX+[1i/9̬Z@WOU?ƶ,(H`Q&mJ"IYq{QyrΓK5K8J ὸMd*ۖpU Z$St{bHXnRhZSs<'- ;'!̬8$YC wi™]7t.[mUvNƱt]oz|9?}RsqΒM9:ri CJi}9IG&7cu}|tX)yڲ_ drP5֎})sl=9jΓs$+Z8Lit}`WIYdl̈>,Cc54@j.T5D{wol۔ҹ8vbF$k7NѤ"u.[ AU4=ĪEż?*w%0oxj"OeLӲڻ H.ETCFJ0+tM%4k)wPTP')kg#Qϕc"'j+FܟLd;ıx９0D ӆOrC~j-/H 0aMEXG5)Vw*؄] ޚH]FՂg<%U$ZLg@x!c'IRSyga¤_bقuQ&SZ8o2|T-DsQz[kM9x#ʠE\>+C8U[;U/d)^Cqj$FJI&i.ro ¿ȣ7OUymDvR rQ]Mu66O)Hs:NӱqV~_HN'1  @ Y <, !b=0ǎ3WP2 ]w~]7'Fcʭ H)iJ6AO؊-_nAXc}QEeAP[FjHgSdqVd2;!PR0VBa޸̰?WZMWYzz]xyڏ& yb]RrX(E;춂!v9}6YՂ\~-0tںildN/̓Ƕku64R EqY'לH UQ\8i8E(1NV_r$y}uZ:R׿JP/z=:̽s|99&s8&@m &FDdIFd$I_v.wN[OCB y&SGCz߯W.aׅO:4z hIcfa}Vك<&FDf  o,=j2'H 4q ~v@J "%Кm R\Ɠ $k)αu Lb9@PQB tɨz =y@3q t%3|- 鷽y">BreMjEUTBI *8f^p<~9tf#@;Gv\>߃ŒD  ?[|}QBhK5yxˡW9$x/">h_Z*]ed ٞ@8+3 gB>[~wԽOּYCI !=jW^И4fVlz׉E2jlݿc% K@Zm?]:> #!:zreUp+:\Z$8+#7rZl3c^}nTT{}!06F[,!@E]$|[!놹k3> #6VR,EQT.h6uh+tx ŒhzdsTeLBjP<,Hꖫ޽ %sF}tNAiU).|3r$ CG|,^jΫp䙞w/y(9xᇙYrLa$I!t_ǒ`b"]/ Y;ٗ R钑g<˫O̘c]g&>(:u⩧ck>A.$6,t_ d:WOYRd$)rx՟}&$IBՐ ^0NtJE6/YV>$qyXX- 6?z~$ )vYV~ Z96Nįyk~/N!tksR6X6; nO>,qtW_G}膆ah膎SSÞζ+0p6 G6Ľʕ<3iR4A"P3 Ma;A{$/{+U"+!芎lE_1L{:域9جX-vL97Rtb@(2{HJǑŒJI ߃sR,YʁcC.BàAٳ'?Mp^tCc`zV=tيD𛗜JbAk0yǞ_<.B;~ķE}1$ 6 nt샦 ~ME7t$hn.sLB\3;ՒÞBauy&I) =>xꩧoMŨAb,!a'=i|>k-"3;=:7 $ _c4 *p#3ӺG:a1ic(,,Lx>̓m˗"ɠ涽 B~CCvB YVL G{:LJ:طo_tH7a"ox7q@һk E:PWEBt\t?;A:)L&EE>^*=q4A &xV( *9$7Ol Y䛪GVK/w=8 2A -߃Q$QsÇm50k&s$0 Yk1ٻ͔TB^2%}J-+;d[;v[w:t(?O[Fj tOn# Y r=#c-w,jIKfyIc̘1=r#OXd W]uUرcٰaF=MjMl?;.Νa&g A_>C3pp7ycn0s:O,xꪫxᰕyCq> xx BEJY5>`ՖyxK  >'V ջ^Vn۠:mXkso ,\kHdIt&+$IObZC}I&JūF”<A{k2]B`Ƈ dP0m:π/H q:%ˤIB\xV76w-eϢCL`~|zl&+޸<ۇ |tT(Kk|ԭ%K0aQNrJ Ɣ)S$sd`<:EHE+M<duG \(m#;jC 'B;/9_; yb m5Ng‡Kߟ|;k${cZeYF%J+ QTE5*e#;"sH< .g}{>X'#0~-97o߾\ve >}£T]s<_|1֭_g/ ~{m*j&Tub&wy'wu[nƐ~WdYE"EQeyŏ5UpXw`@>G w4О'O/_+!S|;޽{Ovv6??n=% Un]ę>C8tḒ̌Ix+<̟? <91`%F2@ߞñXly4]P0GqIdwAkAzJ׀tĮ*qx s&mN@abѻP{`ǤpԾPԨtx0PB448~7tjdO:Y*/[Gyʳ>uoРA-\Ы ܞjܞ0u#u$q~^H jCСijïy闝knћIӧ'ܚ]>3vСCINN&++ݻůk ̤ ,Hؘ];7s-FiE!G}!ʜ4s.Iŋs饗;ٱvu/3l0dhYVPKL 6X @$ #:!t Mӫ`Nj^xtyK̙x#cڵ#Gw^cUmX+ťb~a:0=`4 *C%OkO>i1#u_} ,/K[( / p'HK+غ F!+ AG1w\^V$;6M?~<y}t!D<MyTHUQRv̌si.}} Gp⛧=$I ~㊪*hDg@(Y]V9iDx jâZQ+Yy嗹۹˸뮻`{#F"ϴiӘ;w.}Бf.E~s((>2SMV/6'O 6f9vx. C$8u Fs<$Io~˗s9$ ( x%NʪU5u!h03@|8QVS~Ѣ+cJ)YBASV@)v[jĉDY IYCY,[.mC  ?Θ@Ϟ=ûf&<ȷm8z(˗/oR_a!WI2=/S~8pl3Nl ՟.dbnJ4Z<~&;f=Ǖ25)To/G_.: |όgcN# L"EFỴ̄>Z=!]>*OPVjvZ:3D$q(f8\u]_~TTT~'9ٵk'^4c=2N:H$+MSa\߹8'ƓzTkUq P;VgB0ؐE~Y> sG->xbϟϊ+3.{D̙dϞ=|gD%dY&nSBnhL3 IjG0ڍU]7tT*VTKm[]&^vۇ˝! Zx,XѣG"ᶝ;y@.`W\qÇ,]-[[9xl]AltC$YCsPi|ÛLw;~ߺvaۺ jCU-|:>VR"w@B>6ժ!I[nO?| ӧO?L=27xM0eBh֬Y | 'nV/Yc H˨\Q$_}$N+PMBdЍ\fuWĿV-3EK}'.`QXդ@䱤1: |< Ǐw]uH+G2:t\92uuh {9)OxgA]C3b]x(X`StѐWlaXhQ,FRKUZSQC ?)$yUAVZO.c$, n>^wGĬ%9Sҩ~>WX_q<0Nz1qXX?42qhY+f(]7<u?,{N<>_1rT*h/x}u6F0S#N'~nݜk$T>"$N SgeE=c:~͇# ^D"5޸hu@5vZZ[tfքe3ʪEHxոN\'6!Ⱦ[3glMwwerlkDŽysNrWQ]-Mu'@UU^}laLw[DYzi"$mj8ӦM'.={2dHmcވw<裌7~q=XSM 5.uw_ P\z<Y4_F^]Yr.\"25ԡs"}?l޼CΑCNh~3]Wۡ?5'OЉ./@Ӽ<<:.ޅ{VKBVƗ>VK5jW97A񭜩(Љ9JEU Vi{[$S`U0 =!UB[nG8iT).=׼t3Lb䛳 l]`OJuն[dv%yF DrR*S͚=q`'SQUB#3IGŹr{mW\z==5=3qBb@"π^HNJbwe'Xupk7:OCHPQU'C8s#k^Tvw3!I~.sTJV膁S+T䋾$Ilb \8JR3D!HT8OރTG&t~xxn^Fzi?h,-ojTrxt)nEUsLfIڅ'ፗ?Dfz7*e{Y8XLA.8;a`*^~d\Df9뒑Sgnbx^o4Ug_\RҩrVPVQD7جXTIVGܛh3d*^X()=ΒxrF!K2i)YdI-9Dעsh JIĶ}+Bo8=3X,Gs2`,]tI 뒙*['`ݎS?"#+Nw﶐ԩrFdu$59Gr'mfZ{ǥQd_ڕd{^srbDRHud`:Gl}.:FO"Jʎs~ <>Pg~ ίd X&S>3ӺV<^'U8p| %LyS/9x|.]9jE23GbSW WVEUT:Oё8[l[cίHx}.4Ï裂{ìdc:#]F^9H28{.>Tb$Sgbun3\8Jeӭ.uCY)N`Qm8hïah qׇO܊H@tW~G8N]Zԋ9%%q.nݖbJYg*m@mFï!ٞSŢ^Vyc(k(͚C`[*((Lyt)洔KN~V~]V{}pyY(EV));3mb8lV;^>+UsCұ$ Ͽ}#˰{Vokkޘڷ!a,jW9-l_vi}i(1c\AߞÑ%Y#cHc)W{$̢aZHNNfKLiElbP*V}Ei,9ԤéB\TB}C[\I卾Y}P VrW,+(pI3,#ax|f;Б%{>{" Ii}nKU.uX/;n57)o/o)ucAeTJp"t =PFv"fJYVN04RI%#Ir@0tnh>3Jyr'9蛝KtMjr&)N17fN}4:Q,y ťdaOJnK!ɚ@PsF}=UfE$ aPZQxF.eP PU ծ2juEߞIud53Τu?o/]~H=YR]T8K),da'0wZJ6$% U>5LrjM?&jn8py*wtY,@ߞñV2;$3)t$ 4M &e骠UJazB%iݱVY m%@B5ut5IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJB0eX!eX2  UUUUUWUUUUUUUUUUU_* :UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?DUIUU*HU*U%IQDZZ@_ZjGԚEUUWԏUSZT(HjZU5GU$GTkRO֫QDkZRR?֩?֠/uU$ԏUMjUR5(Z  HBB AA@BBA$$$! @AHBBbJWWWBW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUR*I UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???mm$??pA`sG@@G@?'?'?'??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15z#PNG  IHDRc IDATxyx?ouZW%-[>1؃Eb` `!2lH2l`$.̄dd`60yH001Ʒ-۲e>wxVRKBz[}$B k0:}5RJ$iHLi;O$_?~̠)?@4JiXCń_V'9$ob%Oi;u.^Ǖ+cJqƠ'/PL)1Lc\ƆDE"/MoM҇kݍ@ޡW0LԱI$n.?=qI{gL<@%Li H)@J!z/Kgm*>4!wuLzEz4G-Փj:yr!M C'ınsO#ie R3 o wMB)&OU - ?s!hi;)ML`%C?ZJi1DCY4k+:C{T-l1[N;ۥES t㷘7cz@7"R˟K&=4_hX6!sŔo"^y44 a $BmVMghl=KJ<8xÌ`dAJjss%Z;/8evg_~![-nK-#>>/#Z%ͺG7" %O^OjmK$l֎)KI!<fd8,)gzWc8:j֎щT׿t:r=,gΧ$B=_B"Y{[ޙqW, !ԔA S0tʊfѧєpoO$!P:/ x;Ks/ ֔Bcj"%<ǟi{[mQ(W 1)ieeH)ysoѼJIwKܚRk*y+ +)lgg IBgij(X8k-T$lKijOna6̚1%OT<7a `81y ʱY}VCŨL/zkJ `E9|mlz }(- UQlu#S{@nqROc ;q`Q]KtR'7wk̎mg౷T}&5d}BNoc)̟HgOFMIX^Sf#lKn#SK:7~ˤ#wlǖ 6YHu `jlg[;w(>Z9eQ?71i#/ 4̓:yةGO7 'sTZ`%?ͷr0o*kȱ@&1rkcṙw&e_1[o'|x49HdQUY0M4/miD .6Qԟ?i8.G`H)9q- 4Ψ`ތl\۞>he[-)Ga'u Q5u1-xu=v CG7lZE&MJ .l CWnD nmL$'kFLI|\cg*R<`#yY9JVlPV2VA8K)9y#.~XOu!8| rt/Ksk M'9߬ib\>WDoQ o<Ƌo]7y(̟0sʊ+ySC/uMXO>ϼ|'ԞTR];lRJL)pem+QO `TVi1 ;_I_zzouK7C 1:+]D}/>v VŚ2]=tl;AO?$H[πsS9t:*9Į`ۦ[lW'ơożRv1͋&s.|;_#p4r;c%K]źm# 0mi`Pg/"S09SB]Z/R͛Dݘ5mIc'M"˗đ:U=Oa<+^Cgp$idyH$I*S[LqA9ϹtBC)8%*R4߮-Bk`V(2灼 +-&yo1ja=#a=)uك}ɳjQ ]v P GTUhB#[LIdvYKQEKɽ?b,堽򒒞P'Ł2 P@Wz)%}1rKºe/cJYXhBFY ;SrSMESy|dgEs/!zB]:{Mi;^ҝ7//@<էMQ[Fh|W+s.m )QP7|],SE8{Ft"O*)(WII[WB5)6nDp L,$ǟ5k$hM<`b0 p?qQ $ׁϱ&Ք~ RXHhJH$aFÈaW& S@ۺʀhxcΌ2+?ڗ/<}p$-͓6oy?tL4r4u} `(rwTլ_H$ihF0`p( 7;ƗoGB@0yǑH6,!1 _;xP=&y};6NHM踰jBpYܳGy?|]^h\\oxzoIL$4ZжoH$L$qH,sB(-V 3yBhY|1aPdzcoB/'-懿04hZNkkzۊfSu_ _Qv!"=Lr$NWވ ۅ6bm)MNɳ9s ۝|wY{G~m⼱7AԬKJi2lVt3ᕘfta‘ u+ <ʾJZ;3.Fի?=Z>1κzEUV oXyhTá N SfosngunAKGC#7ՏN4 jEO"qiە45miS7>'*߉k1l*hn?`sD-yll\y_u;Bs_ʤ364@`Wj S00c9?}ˆ\ge3 āq[5y鯿M }'hq6!.q_jUBfMM̟' Mhxl @Jm+I(af e(U!Icp&X.f+_SiUC"dTq< ~>K4,\L?x lq;c&WIH>mp/ۣo-<"f/\Dryʍ4*ԫFVk, ė#VQNO FUSijzS~PL.ei8;P4lӴjn Ce'ua1\x#mj rx ̘1ǏswŇҋ pp)p,#6z?Q aܕ,aH昜=HF}2@zwSI81g> '?=ƥyϣijHVEeUK)'YG^qCQ+`ק~>{/¹-[FCCC7;WO:g8:Jxz|x=xaʶi0ߦgZn41mp[&a6n6 N>YG,EEE85<{<}ؾ};ΝW^a`WB"G}2ċbih,MToVn66m`F?H$ٳw":;;;w.YbN]v,\N1JihhM?,YBqqq~2rrr~@ci*J#DZ!I"}gUڱc555!xGظq# ,JQ SHQshnn/MUWa]xNUrܿ뮻bSZB\+&$C>{{pxMidt@ }=S#@1]]V"Z-[Ƒ#GbHf{wEIc8 ,{Հ}|b<#p*Wc$:IzYt)tttgO1+^_mtݫ4d~hZ胴ٵgϟNYYשiD#ׯO_SSmmm=z#G|VSSMwacpɜE+^qOA'G#qFU! ~WyWvWRRBmm_?ܹs>}z]:`p@ՠ5X:tȵyQYYeÆ 1mb:tgy?A%ֺغu+y5]w]8%ӗ26X[Z?n~Ӎ_Wp I-Ǹ ǣ0ɋw3XM61{l o2xq[}Ola\TVVyfN/^wߝO]kOLUIIǽjqzz;/R7Nj4 &// ,\6$g3zyٸq#??~\i~Y3}bπ`X2^{zWݱA4c}Q+=}G۷'מ Yjժ/!?XcSˍq*sR9QEN`IߝP1P^A~hg`FL.7=y:QQC=ď~^{BE:!ܩ'N>Xg֭c@0mXf+yu?ێYر;v~'dP+/!WRОdIqCuQUYME :pO(cI< gC7tL8i$<&,J+M6iTzP{ V^R>~#c=ߥF-| /[Յ7T ÈxY]~ȭd*`UӠ,AomP;s^G7Ĺt_Ph 0"FS]䵳R%fru0 ‘ -tt50uˮcrar’Fv"sȋU5=܊=URP@(F{RjCJ7(Xp 0j80N;)$7;@?T``P'A"%s{53jtr*FX%b!&O)W$ Yx+ SG7"u^`Ƿ[pVZ!ǟm GzGzTf #L/!7 1<j&%YiS#N˪#۟a ]M|bqOɤMdlj&?ݎߏ?+O C" X}MKDnn.yyJRs(4̓ [FOzƶ b ?@2{0ir9uuutM#%lUdi+Z6?3r4Hcѭ uuu̘1l6cO-5IDATKl Hz;8^}g$(fZ=}Ux؋Gx0L`P'g 2E,}Zi!MjHt#̩s>xȐ'MU;5fK/{x0ҐkLLyҀQ;J0ih:s؂$@#WrA!cH3&MD-vV_ӓ&7W6_9-籑6IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBv0eX!eX-  *:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V'UWTF꺪'#ZZUTR?kT֖QWZQDZuUQkT֨?HH֠/H#jMjUHU5GRIZԏ֪*USZURD@@V'ZjF'#jjWURIHUT֩/_o#Z@  $!! AA$$! AA HHHBBBBAA$!! Ob?WfW#UUUUUUUU*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???$??p]9A@6;@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16>PNG  IHDRc IDATxwՕ鞠 ,FY(1@ d0I`k{ٵymqc{ & "P49ux?{bO4n>}'G"{(3/@8DyشY:wmcwB|maZFm$̜R*k9s rxG:<~ΙW8d^9tԬKG$Y"ۗ$IiDžu:o`5-2PX3x 2 !r+21Mҙ1,$ImzS}G6!`X @S gvww",5{Z # $@B7T$I&??`ITi]>}L(JāmitdIF$ %7uxo>N*mN=N[[vnh̚x.OWٜvECBpͻ@4=Ou$tg߄,+Tv<¡*t:u44ǣxzͷޣ^m$'xc_y۝7||nhFMO*h x39$$[Hx|Q0a]GXͻ]/tcO`]:o@iˁDtY7 IFrfwwu7@U`/E$~ķ2yV6Y9HnhD!jΎ$ҦC&AQ&xx"'EڵIY4 &zXB89La$#˽ӻN%^~?xl#YsHLu!dYAdPDoPqt3FFc4k)"+&ģxAKXΪ@40-X"LB)T;n [;|^o" qjP>D ,I.,p 9{G=&G\$IMe^dYg :u2J{W:jx ^OYA\,ŇGBB`:q5B<!Fƛ{}r !,|ހDhz!LhRaX3M |9.7-@x3$@HH Z$,ٿrY%Ae$ك"H")l\ul<"μ(^IWg+8,rU׏G74ZWBDQp alG7uw '-cph, Ò %$ !$ ɒ̴L{^TBY Z4R|^??{60bD±F,ˤ%@$Jc0--K S1:\GK5g=%,eWC*m+Txm+v#0x@ƴt ktCsK]$mI6S g9M ]r]7`k4x~ S6^L Wu&MK_N(=B{Z)A(3)LM,yFvFMru%7} lz@fL8U!U_mceF (T8J1h\ C ˲?G8)lkKc҄Θp6ob:9s91?v9S# BP2d PFm:q %Fo>NVVWg P9tKOaaKC7òLT-ϛD٘3Y:g'-s;ru!7dYVikpyS]aw8nßc̛,AI|w^ܡ .ikKqe -U|,ڋ,˘⌲}jK|y\2эD 61b`l5MW9ou =pv{(8ϱF$L\tx~C UK} tٗf䃊~ZHFS?4̌ZGR8xI–E}n|*$ jI[5f9ǩ?C:xP ڵ~pJ]w~|> Ir=k?Ǻ_F_/L@̉Kٹ\#a*tC"otl?OG, ˑ]j|*6&m,D$,$Q?܎ӴX# Fěb:ªUXlAYYYdee|wyP4QU>cd MG3gGɣUVtCC$JY!@$XbQpeb*Ҏ -@3Tj[->l  YeCVV~|ovNk/+ȹg~O7Yv,uzNY9uM[řH3t! 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R?HZZU_R?UMjR$T(WR?*TR*USZURD@@V'ZjF'#jjWURIHUT֩/_o#Z@  $!! AA$$! AA HHHBBBBAA$!! Ob@W Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???pp$??@`QRM?n"@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 18&PNG  IHDRc IDATxyy?=޻]Չ$$qdM|1v'tH~رm/ c@ 1l IFHZݷsuWݙ0_=驪[oW @>Q30܋Bݟa ? 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m 1Y$$$fM_F(5vmHf.aIP|iv`ëD"aΛ5׆u<͠ng`j_5o-bį2Sicƌaܸq }^=J5n1a6J@ W\= mG{@ }Xv-kwEl` +W$77={0rF~ᇩ`q?x}Q^~)ԩaC:z'eBb!~$L9zl{DO2zh^}Kfƍǃ੧~JvvvB=ٳUV.fͪO[4l7iҨylٽUmury=p^QL(xnݺaanࡇ_`tC֭[?~<صk:of)%G T'$p-a&t%utp?xs;M7D8qAZ ?lذcǎ-+XEp ٌأٱwjg9:ױ\²iw[7^'bn>|7>z7?z9+qſ;.Iw"tj'_ LVZœO> /LyyyP $ߵSuC^5EV¶kza"Zp`[3$te덏>~2y޴|{oy4|@vv6/pRH6|n喔\缚$nk9Ix&6;LyP فTn3O]mo]LhY.!7?y t{ŰuLJ+PZyB* (,OQYG>E9zɠC<ݍ1g\;C2xBQo'x^222ڴ$':e+7w| pycBwyt+p-WݺuNKZr [taf)DoQTWWSTTĞ={ذa7nLxO2q.Jbb\I=_4z_잾=ɒRׯ~{rexI'6?Ihg%a\5I΃m!0'wl{nv~>>ƌYb\u5'^ #MEn/0Nn_957dךXw3`׮W0e|^xc!_ZpψS쭹KB2إ4-a#W Q_ѥy|k}C@'i;q- }N] ?Am;EQPÎ-'iJ{ QWhwgDXl7488_| vKei}h[_hX o3ϐ~&,Eu^ _4!HSh[ezoc,{ o’&mV:~s{iO>SK 7qe#0k%Ύ')cݺb'iu{o^~56^; .qwHF<ӬZon%aN̉x՟&N]l$N_رc|gkOMÜ@'_R[ހ8T֭cӦM|o'+ t xX,umqg'Qw;b˖-\_*lS,ī{ebnj1v5z3c c',w}B.z^~e(LקOMMUbYEL9c/݊ Kp mAsڼ{5ѣN@7% 6,b %OV<#]6=O׎_2KU~r?G#O\Za'_'R-*5|) yMP;4$ IZG]hP{ l^LSy IMe j!lM_Grhj< K]u-nGa< s\(Lr"}.Wf̃N.`c%IH~X~^벙wcgQ꒦}݇,ˬ]'|z?UchJ15D眞x OaH:J.~`b:Duuu=s=)S0bz,,Z|0)G}^xѣGC?9p)L^ޢ~2`h ,Ȼ?~yWROMyuߛW`BOaqA=P=G!t '̘1A1j(4M[nt҅+Jn6Ou?~nHϻ!,^z\>xvI##0myvbE]FU>=g83sLdYSNݛN;<}Y[1F`3;{ [{vUz2>L,au&q][f ӧP29H mYߞ#[E5k~;~zoj^8Xx*[2~ک nJ+ ;⤱wMI(KvUDv!A> ܍V}u\:G,C h`Y\dYgׁàcǺn\ Ց|l/?!:"704 S$OUԩw?05,D3\҃%Ûxb>wՅk˖$I:$ɓԩSҵGЍ(h RTV "-ȲߛMnV7r2^VjH0ut#JqcQxdet&ß*<%:cRkͺa_#c&f`*{9~ԭ̉0c²4tGYdgv&3#Кp<1$(JĴ9"8ZtkFcm{Zz IDATNhZ]B,s.TT-BX 0Oh;;ZXY:wGM*yLD!GMB_/,.eşO! ++N'y p ta&!; dֱ!&##$ Ol1Lz~o&$aY&FaZϟ2PahFK;ǭOJ>Lb$\ ڧ逫yt#JT #5< 4ݶi膭xNV%FCXdn6\u=Bmm᭘xOFDa حLAV݈2˲0M"Oie!Q-L$05}C8:hQ MkQ<ɣ楥$4LP04 n:\ӮQrU:/;-}<EhFPMQƍ: " jX !#MI8sz=g찳ak@\J/Ψߺ/6BM})4ut]#' ByW33Po|ӋC^*Etī>FnGAY1TKNf8kwǿ>So|bra0hy.;6 5*|Lw0*P,Dǘa3۴l a\9aF9VD$ܩϷM[hv!ofvI¹7%eS(:XN?/|`zX:ewPU/6q-ˬuP,%[>cۏ41ﲅe(i"ORWf^K"Z/)(Aq! KPTV@ITKQo,m%WUSnjԄ+Dkj!0fLj &*j]Z^ ѡ2y!5Ӱӽs|SRql>p2snO^KzzUהÈffbZ^TEez$mv x=ÎtK'hFԅh4IWf[]:z23l?Z fʫSRqTV__|g6kJ `P%HF#Ȋy 09o>O&s{)G&W!I=tA4j/r$)ҽK_ W5-V ʫS^]DeIRr Q]SJT W U)3\]TŃߛߛr٥#2A(>f PSHսs_GeUsM6d+C =2r#xT?^Q䡛Z!YQQӝoԖxCL KԞېeEQ k0(yΛ~;۳N8HL@dGʲ lB h;jdu%xxU?^EVeCg[C$EVP NKtA9UV5a)գs?$'tXt2GR*gid7&TAMP$@$ZC$ZahHĨ5xZcPduE!I2 IQ=-"+DtݎK.sziqG*dIBB&7G7a<CQTTÃ5ۦ,++Gd[Xǫzף i_$aZG[C*W-BS^}pp4jED0F4oM9#H5b`0MP4=|اPTŃҊ#ѓ)uGԄʉjaʫs[VuDhHp4@(@ףL9#GC)忷KaϮi_oZN3;#:X)wp6dgBHYwh{`=4 ,af1y|-klHv T5x k'*dI[Byi#N/\8e/-=5uoҘ2z 9^A ˝^US4-j~o6~SGߒKH=mh<#y0~LAUM)EeJ[ @I<4LƏ}k]i2P @N}0-Ifaژ d*gwwZ:6 Ppt+M( ӹC-:Fill[BSX_m FZӔU%eIq)) dH#y,a):FIo{N4u,',9U@c.GXpJKɉl}݁7ZȲ=jecgu%AAafwMyb(8LNa:r걍C;!飸\Xw%mĉA |²+l(:/;C.r=Q[ƟmTrSDLodZ&0I}ϓ<tL 1aY(2LmɲK* 04MܝK( ' eԡMI cӊUЩ ayiҳP,oDc0ҴM#WXֹQ(MSUSFe@™s%M*w6 *u.)([Gd&Pu)U24-gįrָ Pd۝òL"Z5MJڣh̓?xf[9w弿]R"'Su DU|_iz-{ޥ(%L%:׉k!j•fu;v$$)ήEBUӗš~veiWmCԄ*)*PJeu PrȪmG3v%N Wтar\<BIENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBy0eX!eX.  UUUUUUUUQUQUUUUUPUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩T*#U$GTkRO֫QDkZRR?֩?֠/uU$ԏUMjURQQ*R5(Z  HBB AA@BBA$$$! @AHBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???{d\{$??aU /m9tE@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 20F1PNG  IHDRc IDATxyT?YjꍆnvV@`hpfQ3&'yrz'L&ɾɨc4!ѨhQA1[ݵz*}>u{s{VH. @4\E8T2sm"u<P8Nli_ H! \@0\@Ѹ@ (sEC+ecF@UT)ml) ɑJم DD`=6i`Y&mbKiF@ ((Hlqs3"13 BXEH6S˲ lּ"TUC *k8 / EgKP$NHv2ēy U it-hdѭt gtRJFxgܑ0<$P#[θ D#&HicY&:OCeB(9繀3GA?VX XEY $!z{;3v*a&MJlTFGC9/:ƠzG^9|"Ė6D+k*uI$_\~TSDJil=:H]UuG0{i/yjM@ض}ԭQ]QG@;DÄCeH)ٶաڟ $OUy-P I%Yu@Pp H}kCݵ}gDX45-MN6na"eD(Bw_nӪ(* 1-cS<ێo#L{G3i#܆e\/nA;3$y@SM'H$;Qφ@e9@PTQt۽2ÖҶ΋ē.J}VBUl[bv@hŋ&2C\]XD`;PHGʞ! tGMl~38م֎t&ZI$;1-3;]*94MAJ?%>Te5H%cy>zeÈFQM;_. 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CZ̧̚vO@ a`L,aj%i؇]95`ܔEYDMeJlA+U>XZm g utCi01 3H{H^)ts.,l\,BhisrMi`uO>` GH~^T1$pOS<e%B0 :#>@z59/LZ=i-'}Q>TNg0ҴA)G:/|«TXyKO|& PR"X'Nݩx/% s߽,5z/Eї>dDc=D=#Ԑ*AD.qc\o0x5w5?l)M/ڙ8"k J#bPFZ>UfLev{ɫuQ^ZM a&R)z[G>hQ^R0c 2O8l0CR^I2؛TT)+bFU#]S=1[A` e'2vH_V7Xa~$=JJI,1^Oŀ0A|1&T 1Bc7iO#B?AD"SgFm)۝8x?'O0$%6bB'OC D=iV͋?I1" r,1Ҧ-(hD*ѱCmSH1dP̟B~t!:nJγ4 _Ջ?M]cRSPEoej^(E+|ln a`&as%A*@~Fmɸ5G&y_i1 KaUM `Ks2h+kDQ%>M hic4Y~>H_}=SZ7wzf |1iaL3%a*IUOt+.ƶmZ6 KI#OҊdNW8@(-1upWOpT̨#t͛b& 2 K} n;zWd<;3tjHDZm ۶8nM@x᣻&N&Ӗɔ+DMe~ohǗxk*OX"PZiqnn$T$Ի)dHՍ~\2 :{[&qh8=c<^mZq,W臍#mtpJ$v,K}ph QW3/mj {vV|F5Awu_mMe#88²8$丮5!J#*B%q+i˖>AI\+ɮ}0L@H DZ;㘚zg8_c3p=}YvJ`9 :'tB+T*J&O0O'.:K&%LuTi4t` L0$\N8TJ$TJ$\N(Y˱8(MWp/&8Uuta)̭_⯂v,9.6BJF***f ?b9cIENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJB0eX!eX.  ꪯ **:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjKTIZT(*HR?R?Z֤UMjUIUZԟjTQ֪?TԏO ]UI'#USZԍj#֪  B$AAA$$!!!! H AA$!?bEWWWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT* Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???$???V)>=B@?±?±?±??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 24|6PNG  IHDRc IDATxyU>ܭoK:t'!! a @, (.#øe|tf|yQwDN޷VqNvwTn-NU},!]7I[B$\HH$*w,̷:R4MC:B }BdR?qw*SP@.2H[q -\Xtk)5S-D[4\qy3 JaZUPYj/ ۶1 ͻ8xd:VZebׅ`s 遡BL%4phrmx?f$jp^sO\I9o=;ȈE5'baBH?Vɬ3 *Gki?@kyXX( :!D2o.9ܺn,;KW/=m%ic TJ_RY^OW"=G8D¥tf5y=-[9 p{|RAw^J5SwLX+fk" p0@40R*=בR=mdМ%DBTWQY^:mNI$q8nCgݪ[F*H$Tx/,' B4Bb aB0DJ7nκgu/*w3.` ⻄xDV=z4w]+ W`&@]3BpYa?S8Gs jH)IY m!觥}tiճ1 @p0J8XB8TF(AJɶ]OGJ~ktTwg%:{i25lD#zb43@^TN#m'\)fP`P9HB<(ZOi>&?SBx.XvYVREN9D#DF0 _e%G,ԫm.*\.MF :ͭF=kNf>Wv>Yd&e\ɼ+ݰC-o"̏]2dJ[I5 sD51~!_tM'C{rH՜]po;I@'>>~"\pïϢ\O/J)G#2ա`p1Da3 m*̾˛MHL$"m0teײ`ֹyl Ļ:Fo_r0v3jnĂw?Q!~=-tC i;-mV,X| }v>/N/W%xQ&4fx)oΞ4J'$ XdKϼcתEuϟϟ òӤT5oXH)uiEjĄF=ē}Ql 3SϜx7n*˧7}D"ÿI$۷I6]T$` WVT1 v쳙5k2ۼ"#(px?/%`󱝼w3G]oNʊ?;U,6ybqlb>zۈ%hh!9srz9x+ق-LE*LH`i<9>y_z5O>YlA t7ƋҒH8v(f,[@[[?^8 s?.D)RxrEےr/gϖ]tڵkN! ]j.u͐nJ!4)g/`T=o?_Wϖ$.muV)D* ?0 ڲl?w%Ӧq=?ر 4B!0|Sf]7Uts9v\V O\stiWo'noq u4 a MyAk,nxH}H}rʕ9U{Tߒuy?Sx޲e rӦۇۥ;X}!oq\;ghA D|L!=_,2{BӼJ)$Rr 7|T*΅~ x۾}{^;3x#}in&H ~#kGд'Iii C4䗿T7gȻ޵i`K^TS IMI]S2Tg /ozb1~Fh%8z+?яriz\ZzZ/b}6|=̙SWʬN<{Z-i# f>!Q#r$LnW:@i:? =F 0e.-Z4o|c˳>+jw 9m,HF*dI\̑Ӫf :1e rٲaYpyJ ! HL=MĻԖGtd9MeYܹsϳl2(seٲe̜9K۸q#>( Y޺3EkHsKR0=_ecc k=Vp}@PN"]{!f5$IbK˴J]eSSաnu C~'90ٱW c6ҡ?T쿃E0/He-dٲ$0NXvZ))UB'&͜O(.ށ~=sۜ9θEs,\IA fK|p('c0_@c(ܺ PqtX[5EFiMɷHr~3sfq[VZS*]=rh$gϴ?EMEGD ,$cLY$#@Ь[.cyMB%t7MwqcǺ3B#.4RE4RI$y`HY\s eDظq#{.>z63th -IIl'q_?XAk>M0vpm(b6wy6%r>O_M7#d|~ӟvx;Lò`@9s@$klD(6Se8d&/C٩6`Z,vDD2F*Ǒ6`:̭?h̲RV /`czmm-lo͸&蚁׸y\sxKl\c51UW]~qxG馛'/CiG?0@0fbY)v(&\A$Onkd nuV-& #c<ua ;ؑ6ma;=taJT4x}so:g{+1ֹĒ}|fҥ<+$8Z$qslٲށBV `T1d">]>4f2'`H@'^ .'3Yt$#xs kZ9h/]"=2ԺVJ{Of9qxЕS"Ye /~'W\G[Z,=\rI_*=VZ_`{K sp)_Mv>Ns9cɊ .%hIbtФsn&`O>݁XC,Wi:PWw>oٰað׬,A|p!}P =Ue "dHP!{y{Ws"?_œK]Byt:A@;F,Z_{W37+P]Z ڂ79TM'ر_^<6EM|`䂾5 |A\x7O^|2,}>p)e%5D#hB}1N8TYR]1XiX9#]3A|An6^x.!Wa֬?X,… Y~= ,`}X,qÆ ̙ BTWWs}0CEfn&ͭ})araٙkFp_Mjz^{l'gX,ϽH^q; D9gmn>by篓K],Ͻ(/_Ї>4hߕW^)KkW_-gy{^CɛniIJ[֬Y#I݅r%K;C~k_@Di.WL D.^^q\t婯8Mu7PuTOg=M3ʹY1s9e%|RުEW.hLoHCCÐp믿g|P L0#駟fݺu_~=On= ݹfW\y9k֬ /nu*6,;5VgTorЋݰ[:xg/>y4M~!wUZcrIli(ܰa ,`i&F /^<"-&tvqR)l^SLp"nsˎU}:2LH5 T7PWDi+j|A3LxnRV2's*4Ä9r|I֯_sg>x`Ù!`felH%f CGRI(+6LiIi+IJ[q ~8.i%#Μp2X^~dd̤TgEz XEJ B8%}WٹTp7IDAT̚ʧKEzPi%E,͟K*P!3pIQx8HpIƲS$$u-JKTQTqIVJH(TpU_$G8wCJ^Ղ$Gѳ?/~gpn,ծ^40\J]C71E^gJ楃n ƫ~&1D#;r3r%khků֘+3&H0f}J!3xS_=gy{ gcRL'Rw-DMt&yMgec8l@Sxʣ~P@t8.ru;UTOz\ 4]W׹\gD:L]~µ nG.\Kg_pILǛ6mrCyi3F043B = ǝMpTcQGh.## xi+IqUf,Xu3Wa3M6_bF@'}*mudjT:mIme#uMTW4LPK!αwmy*Jt=6i+I, @(+wyVDCńO1KHeVy%ySl޼Qr53<9_>QRVRԸU@ մ}A3LU piM N*<0 Bq4Aj ܜ_>y/>,{O'>[p3p_ˇ_~>T#;PvNy/Z44Nkm5jhR+M#`bS:Q6v~dEl޼O}S>)YG>G<}'sΉHXLYQJܖ 4Xcx'Є mjEqzgqe%5dwFC8Xp3{QL駟?sxf~-[o~g[ d?Pr1/5^Do /Sr ESY myva}})휂{=s}|=_[uj$D:id|xg0T/dl] $tN\y+фFNq57Y@+a)XE8#/~]zWk?4FX$!3< ##s . x7OqWh$4N[ǒst.A[(dr1dCK[eouwS6GweFRKb>x) BbBnXV C3Q;m'H||ݩr` JJq_+rzz:S̻C2goVuy=YTMc oyDg"D&M*w;9TXگ g^BoV"sWdmL ;F}leP\0VPowHaF'6lLݤfeנk?}elWtej}Xm; & A.sHhn RRQZKO;]犐]!tV aRq !R"AxR 9 KaY&/-\STW1z.W O][˪>&5N[@YI5奵*S vyS}mS1/8: Bѳ* &x< 6]eb.WDSuR"<(Q:#%[|tHá$\}mj%bcݽp'=}sN#%m'oNe)B0sZ&3HzGJ I<ς9ǖc 㺨ame=-Yp!ͥRJvRXr*K0ӂ~/` ƞKVG:e\?rݺQbO,90]G|l&HC/lsϊ{ti' #]1`nr8_۱XJ$_<.?Zm+<] CIaʅ&4Mt% ^~s0iuB4(&:?kKTlK$?2?F*j,q:z DO'q 4q3Gj$("ZG$Tʟ-cVϞ` 2,iS3?OE8,O#_Ͱ #+?֎ck+)-4RͫēšeRS@UY=gzOSTD!Ú,'QP?$ $v4,+3 I)?dӑK_" au҉A~Ѧ8Zs^摲:PA~eW3Xk>?hDc"'NלyGq>>RNA4\#sn:zZƯpuO1f(m٣n dJ6"p$AGQ,;EO;]x/k"c4s!) 麩Tn*]$\8F ljp GHLr Xv]~FGQvz֎ {ǿ*N&㉆6g<)Zp[ӏ !GG_LϞMh޽C.דR4)"%c.^v-+9S `(-kϫ!~ - N#AE|tQS1:JBeݍ_Ʋ-h~<>Cwq*˦SLCt ouI:HK*W~/RB[ad [OgfJ `٩1[e}ץ.=)g༣+ile%])F]7ۍ?q|򅡻\.~N2)A:=It4ڻy&3DIgͨ4l"qʲzzۑR`Ǻm![*-f0>4 p}fV.Z.Ho2H')scKW'z[(Fgo (/q1*/nջx凊R v;hmI쓑P ;'Iwsu;]ǨQ]1h-{×Hb7~aUW5 )dm%H~ץ 䵬HG:8H*zϢ+Y>3yfI1;fEh W0qZ`kH[JVycЄ஛w_=vKK gF|U5 {O7m+[gSqNs zO*TvmcTڊsx]3AMӑY-~BCCc-ktmF*J[@yյ"Zġ}?}.Jsmض0-O΃B]e^X>/ `)|&I:FG6szGScVj+j|0yw]y/jt͠?A7`qdD2.莓W(^MϙH)?x~)ǻQS1SѶW^t;w΢ D#WiоDj% 47xԸ#:]i!%DΦ*Jk)7| ]7| ~eSIR8tRI}#{fM_D@?lnS((-ރúTxLuEHxeXrٯ ]7in֍Gqɕ fmy4yyM+9yHh `Mr,ڻi:̛~Pc4'N!hFxT*JϋX?yR2Jx5- ~nr?#T4—`Xp)^ (ns|1ƃΌt[k@%.3%sڡ17&rpI/Ń@"7 7k= _z<y۫_'pgW۸jڮVw] 缓XLehu*8A 2Fjz)Pd"sN#|;b=Zv}i^z?' fg1\yxlVOzkOF`iAg$TfN|k.x/pK,X#5U2C%=4=Np!qHIENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBy0eX!eX/  UU_U_UUUUUUQUQUUUUUPUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUSRJ*UU"R?ժ"?j +ZR_j#[GjZI$֤kTԍj#֪  B$AAA$$!!!! H AA$!?b@WWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???mm$?? _p=9@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 25#PNG  IHDRc IDATxy|]ekCvICMK e(@eR)"^9zu8ss(zDQ) (B) mfh${gOkzk흤iwva?IzV#ּMe독zlA` Db}8B ؼI?b6L}RrA&HLZP_yB&$h*oF]19! kW`҇  䑼GdYad4rq8|`dOꪎΫ}c㌪u\vulgrܽDkEeȲ̋;cꊆQmsfW[ͳt$YAcȡ̑nlG'^8{iz,Վϼ#lƲg͵)bYr:)3>\--bLOk~ 3w\0k8Yy\4kx;6}smܥ: %IV+'#tbrl`5Ms*֦mDZqA02PۊmE#"Y=\&xR /2kKe޷,[|mc6p8mA}f!j+[GkWQVE : bȉ5Տ"k(jʜz8㰿k7d4}P]ހ@` Dz iN\] `;֤ۍa>-,Ɉ"ف2y@ [zdYAv:pF3=6ab;WTW4>l@S4xu saӤ};"}!HqoP9uy`wZN\~$94fY7bq׉mܥ'Y cQ,X{<ʲ\4'sf2ܭ(yBl6+U*~,<ۜ+LmUYE%8s v3'"pɤ8={3S7BeUēQ*Vϧ;e{.;V6dv"=Ac)ۧ$W lU} ru9uyy Q^Vey$B;V\6ldoڕܲb8>-H,1#4Ǫps' ?ϼf, K 1$Th,pvk*=H8TlF䚜NL+E_bLB6HHcTW{U7on>ko%-G QWP=Hq*A[sYK(Ruü m[vBdL+UkrB,v,`GO^$I"FW]*TDzO$i]O~sul cnI`'י,mW7^5p e;Ͽ^ؐDOH/* T~wQPCttT.~cɣmjUDZ1$m86B8HS=َ"(jNQT*cq(@ٻgj֦AFlXbX"Xn@UECU4TEE][owH '9Y@$tO4:2cB`;Vl)Gܥڜ)-?giG%]>;n[5R)lD ѤQUYIZ1 yvnabq'5L W8R1ۭeDZB(X.JrQ-5LM]3\/ļf4G/̵m۶Fcc#555DQ>L^p04GesBx>z|4+ivK"uO;B8߁mTKnwߍisիy{KKK -ϟ?r^ Yӊ7Ôij%(Ƕ-XI#NdHp=s\I4>@%U`;_W2=_|鹼q|vښWa)m;?ţ__'w_2=\¯U?쉛fi_g(Ox0tޛr2xK:y[}5؎M҈gMm-Odj]26¾Wڤ1 ̂ dž8&{xnW3%q1H(3 ~YVI1`Gr̯a cik=H]OcYt1"19^>M۱p 2 Y \:/V=i.? }]z̼I嵐8z:8s!eN) TSYw)Nfs55[#E\u 3Ign6my<,Zhʱo]TW s{Wh}e$lܽQS 8=VwG^i${lJ_{ՁͩoeԿvp {;_cӖBn|\G+6M 3XtW饼rp^ }f~8E6 {챜VG_޾.udf LaX)W8^.!RP1!DV/ Tai 4۷Xw:{cdr) H$Rce۷o3J>pnᆬEIin-57<(t败硪NNt'$YXi tE#2xuELOF'ر믿}mذ:6梋.rܒȔX>(;LP_,.sI2":=J")UE֐YQY(e$ü܌EOĻW^8 t4^|E.">˗9YOp3'F߇CÃ|n;YMm1]f Ӄ$ɮC|@QTt=S.Fdd]u%Ȳm[#=\ x4wq_aӏ~O|V믏1Oaǹnw`F#rGE/T[Մ ~=W*X$/>wMIb<ʣ,_kr=7Tŏ<i_2i1Myi%e 7rwLn[neF k{QYV"<2|z]w| .iCHW/_m ~b!^=>֭cw}`>p(/g߾}_2MyB)#g=kе'c.]^MgO,}ţxm546qu՛Tɲֳ Cg o~󛙿_{5{1~iydlȲ̝wɂ FD2?;`z:aKk_~9?$uW]ya+c>k?+/W@/Wzp*}of1=9s}t nM'XiLHx9>C#eRܑH-J !l7c߾}]hoo硟=L?ܸ7@/X̫YuhuxQfB^3z^g"׌#45&K/#_b CjRa>jAb'>r\'=QD̲βe˸'ooΜeXHb)(!ݚHeꗸ1^t^tT|IrS|+86-!uȲ"TE%- OL\|q׿/d~=׭['Sn='|;'W@( TPJkDEY* QVUljb^uh[$ꗈҖ3ĩKϛov=:5/86AbAefȪ… U /ƍf3˧hǎpOFC '8Ʋ-, +i&1$I3N"%""K s|3ْ%9Ӓ#f4 #_r3>-|%No'*6l0oVկN?τ篼6y)ܰwK:ym_y *ּMQ^VC(PE0PA(PEYҭGҴmFL&d``-[3Σ>JGGev֭[駟>2]s{5 n47q/aA2Y% M<(+"g92~/qG  7&I@_M A9*AF?\Ι'^腪2av2 /Fp:4_vq=mHA_g_匟oӸg9`~b(%~~N 2$Qtt6#[#o<:.=#D"ټyd <@+ 9>-p$RFD*FPIU4aOj&"gg_y?LO8RjZ( T׃(x`zHXv 2Iqd * PL8IǬ O3w‹nq2~{&Ise8a+WgN|!s;@uY 9ηs>_0Ӄ /$ĿXb}~l+E_u7Y #V25 -;y 6[t-E^s7cޔ{Z<0J)*V<#i\EήG(sd~N9Y";E9ϓ%5ĄhݠPUkT>#=EleT\hb%fGшGL3U4UaR}RsLPM:vsd6O[b.{ g$0t%rϜ%/RSHb%r˜<#ޞ!Jueg7mN6)W`odN!i1,;-g U@νϏfS3$zS訲hcX"wHۄBxcEA7ГcѵB 77,^9Mѽ\={'h:,cf2K"T'TElR=!^y7IO:mgAح'HUU8oryxo#v U%v(4VE.3Me%IS|!6y,P]{Y}Pit¹}>WNA֡iaB|,+> Ulyw~_m`Ҹ<#kτqYQ[D},cL ZHG|]#$K/q,2nG8cbSV`Wffxı eޕLIDATIb؎Ms2O`NI82Y' MJYTY>ϘH I 0x(͔&e+ޓx>4M0>pʥb$S1a2R`3AֈuQ  U&DZZNBBbo׫zsGee[:5MTHRĦ 'eII Sg %抑fL&875UU`YT &'b8>a&IIfRc.z8Gt ~_D2PόK 1%HaI3|sh/>/֘j*$H(h2b$8ai*Da/D!39IHLX\б<"\F010؎4Q:z|;%L>sCRތ-\K)}On[0$d7snH4Ʋ-$}ɣD1xZ矂 L{ y3QgKn7. #7Wmo c% K `0KTy&)m !4b 9M,t:'O&paCtMo b(F)1,k=EVqC&.pPd!8IF<'/^@`FfP~pI K20$To 4յ!2p8XuTI0I߸MMw:Fs,&Q0 q*PDnPOMDUy8)3>'69\ IAx?gvm|7UIENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBz0eX!eX/  **:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩TPI֩?ZT"QDEK*UQZ֤R@_I?RQU_j#u֤֫kTQU AA$! @  $  !! HHHB@  $!! b@W Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???~H@~$??K[^9-B@?С?С?С??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2604PNG  IHDRc IDATxy\U>ZNgll%l , 0#oė(>#?GWaTAHD  @Vt'}v?V[w'n=ܺ.yD-<g_yxukW] mb&"8Իgq7  7S]Uyy\sՆ>~?~x"N"#OD1L1 `v˜~3?Dz,,0 t0 ->|PB8?q~aa`"ƣ8s{ĶmL- 3C*#q͂9س+HF*5q?  @T4DX|>Lg mceƲG TlFiھP6y!aky}a^C,D7FHc5],j=E(h/#mYx @0ax}~|lS؈e[, 0 G۶@"C?WTW@Q4ECQ~v:li!Qɣ /%Od:E[2;YLt3Coitӑlm DJ}{꿧 EUQUUSQ UUmgKi!"Rnjg6`X)auL"gQ ض`FUTU͑ӶKO1#O&\]GOdҤ$9[ {QUUCQyeONJ d $\iѼXM:=iē ɤu#tHa{TaqQF,$2oڪ\6T!`Nd7TLڈtt#=#0 ce`" u5ECP#uBLJwUXzBW sZ|!GHic:#5ccZEVPԴEn/FEZov%+ ma&ebYK$Or~FjZ,j=]+$ǜ<^O[:`2,cSF L;[iELGRlѩ5x~mcIE'f7!*BqAԙG@ BTca˪x GS=Hi#@ 3L,2z rE)1z%dD?"Ɓm4-ӎ/ 1jʝqI)i[< #4_ŞASGř lrֈI2z"ci(Re^wһPEβ_QQͱ6;` ̙'.a;eШUxP[u /ql$,peȒEqu!pAmׯ6lE(RCU}M6mCDx5r`iQw7^t區hb07Ʃ'0Lt=C&c <)|( 9$tgP?dFHE$Q ǖ*:_j(R"ѣ8]sه0444Aӎ'`46i+OH{,y>Cd2 LtFUT!knB RHLMT*yxA4XşC!к׳Q|.k [VaBZמ{L$z^BUd2ҙ4t C(¶po2ppRlg.'Wqƣ{lieWDD"@ BTUUT!Px敇u:us%_]}& $dD2Ap@gND;C[YҶ0I|^|~55a T FӜ廳H9N>-\K2BSu410ԁc;GعV 4xO h3 Ɠǖ ò1- ]h^rbYv8 N<wTw\`mǙIY=4~ },wBNqW׈8o`%Z8&y {oy{X]WT,¶,LĶ,,k޲-׭U"2Q'#Oxk紐}ibX&i`YVm[HaيHnGsjo"$J* JL%I\{4F`Zhm[cv؏&I^'˲r$&Z(ҍPLۦ{`}_{qضS3r3i,9J'r,g )ik"y(BCUU܊biHw\C0P͕ [m,n;5&tȶ-yy9"43N;̅mg?Ngj[v"i=AJ/W쾏guuym917H[6p)Nt|X״rk))s9jԦSqJ#,ׅ@F|@S=h7w|w 1F]Eԅ;{,AdAJvx)ف8H<=\UnRRnf(6;|C|ʞ={x'Kzvs,^ph[iD壬RU0mo".j=]A ҙ18oKS)bAҙ8&ΔdqGbLtR* S8$lI4m։s1҆aSCeWʩyh͎-鳵q)>o "p F? ZVM]bI'(PK:!nb8$ +׿u_ |=_ :_Cg7Jn68'޶*Cm'(ㅠ:A %M,]ѼG{D3\3*#Ӵmg7OS/Orh\e Ÿl#gv!De DڟHet%W( TijޱIJS-*NR0t/Ĩ7F ~5VB`:#~ҙ8Cvk 5R粌-_tj.2UQ܀ ʳ2&-'zCP!d]Vf,ښBAדth=?kBnUlKCWVH:]-[)5 M!s9lV.>Wk'$7\?gyʔKnq֟z=ՓGMvinUT&VHԆFÔFصUDj}Ŗ^Ib޲e wqwH[# I4G{ 5c=.[ 9%qnF[q֮XҟZn1LYd{z/om@ 6Q,9y*d2=Zbli9'DH_~/"1 .'$/5F֊{R)fy<?ZX5Mы'L```{PJ7wN;_wjHFAG?ăcN9$'x'y'er?9hmM%',,ݜ76ۅd'CooC7V_\띘vk}ڹb.qJ/}Ku]ߋ㭃djY5(Ҷss~ mv7 s,5۾J!LEA !M߿2-2]w|\Yױ\_u]|,8YdSF ϸ~fV[5L(y ֢;=?Sป`O&>׺2C^ r.`-RJ\里F1}}6fP,:, ۝I>͛Goo/{'W(@P;_PRq)U0s znECdpX70 . Ըɐf8s-/lvvoˣxs>@  uVyʕ^4''@c|jSWRQyZ xCh7;^mWGƾ/AZ)oRrǧ?=ݣҋXd bV#x%Kz%8PȘ#|EcH^$w]&^ ttm0$#$F336^!(Jے3-qsع3/H”@D"QLV|tA*%K(ݻwř叿n| 555eHM3 z;HcRr7㗥0׿ GlK\r%MG+;6OcH$Fӷ ѽh$S#x9?#r6nȵ^[е6Á?o䚦:_nh>:v7I!({/%מBN6tLcǎ|ͼ9!>XOkӛLRXxBxTxՖ(%:͛7|cb(.~bnbot%"Iϼ.Wy ۷2#FG25-mns3:^ZZTS_GB[ittmg(M>Au׌WyjP u,IqoGN@Bpå?#cD!jvp:tm{`?%B}*ܚ^(J# 9%F Øso-zaZFuㄠ:i,|tzmtk->R?TS!ݹ,m P6 3.{L3/t&+M5\SPUr}{yɏ tmg$᾽ f0ڍ2JTֆ PUwlذ}c32yGxgFGvv#7tz.Jhfjm]lS/+c{* [|K?`Ŋ}\x|K_3(OuH`P/ΩHjZBxT/p_1yb Lf%T/-i7|eyywZZZZYf sNI}5,lYWEMu#Fli󫧾YpEM[RkW_}56mb0dͲeyVp뭷կ~X󹊎>C9p)%Wm( ӵBIDAT< CQG m 7*g}6WFUUijj344͛Yn7S/='-v?3dժUe] 8rw1d#{(?͂D״QrB J"@xG?:38Z:>򑏔UW]ESSYfMQmNnʢEhoogѢEɺuJ2q(W2Itcq Xe;ID_{v!ULK?|wvcA P&[ʶe+{ $>6ṋ/X^(?w$ jym͛7W,i;Y*y;<~ər~r Ⱥpiu5eǝSx ZV+6ȋ;(gMfYr}}}Aq|J.ŘS]t# xl3 6looxG8S*b#jihG*eH}Ph7#]Hiٳ)~fYuvdpnRz|ڠ¢pEQJ{$~n֢r-OyᅼZ[֍/|]yǦM|}me;|~?N9޹K Hl۶7x믿0q)u5r ñ)&Ph_KD-i;yˈԴM_𺢍f8L6ַxyG袋׭ww_}L&æ{aըvvb!2zvgyǏc֯_? '믿-ž=ӧieAJ7-LPHIuҶñ^8Dr܂|tS sP$ylWA3M+?J>ԧJj_thƍqx {bψ)o9y'Ɲ{H$|TBEYn '>o]w޻p+ٔt$Gu A6Ymp RJ*2Xz18rd:JHq5g0bHSMFyd$ %Ĵ1M?XM"5DS#\U75"?|T&Wse!lT=YH(XG$<ŕSAʑB@J?85̧|''cw´t<)d%nRM?p3\M ]= Gx[:t=շӕ>gLE !&Ϛ]:w?rh|D::w$Lw\&x2qbaBUw!&ۧc|}Zf  7yI FC0G'V*x?LE(|$QK%Eϻk}Knh&RX-<&QPWͨg]1FyW~{GR HT:F: RBE0ٚ$YuK@p|ҙmN*蘿j "aƝ"&OK};;]^*)WW@0ɦ RqG<5iyJzhqKEna9k,{vy$cZSGZNѶ0%k\T[ԧ$O"5Vt^+@,1H41asBgǝֆ%(B Ίǟŷ3 l\'[,ϝopd&F_ ܵr!7 ^'ER0!c$1M ސ[21ښLJS'ßyNfQND#nC><}'S`(K:G7|*MN@LQn*xj8W[Z\b=f/K\–U,lY}K,fuִCgZ:͘ںĴ 4.{,7OP9y}3bԟf%N7Eh,@u gE'ce|kɖ\Unе_IJ,)Yp)O^%Of^S;aÅ$   Fr#RBk};`EQ֋3j)_M"^m[F"zH[s;^2vjMF͖cfӐU`EH,ε%AiXSPBUzTsg~ ZҰt&cW%\@  JUJ ߘlXjNXrad nF} %m !Ⓨ;wLH^oET/p#'w./2&\UzPfP> \mU"WS3_[wl_yb$H7ñ^db`C.#y4/+Zvlc(ڍzQmV  ֺԡonDav#^204x?.a~chb׏m aj=j8yyl1zHu0j(Btfe ;< u!ҙ=m,Ѽ4 h_Ṃm{-M}M+|3D7-S$#kFDjh/x?o~8hbYT|[: "ضSXUEA .K b 0M IOOF2'!+-w.`ǾЍ tML;cI)m]Go-/Z\= gE'Lt S031(eTGg~JZixkki, RDMu:(Mu =稺ehWw˨s) L 2IzDjT&VLwR&N'R V;t85z>qn) iF\ 8뤔{-t^-]O1R9#`%dXм|j[z<7X` ~o6-Ԅn4wQEQ4ōQ@Nd.͹$ˑI*G@9Z` u(p3|'/ϬhǹrC- ZVY@}EظG*ePFC|"&jHe)mҙ8',=Ǐm[ēCH mXr0.XCkC;-մbZ:?h>+B0PƯ9A }F߃:#9K]}Ǟa7pUF8Җ,lYI*D2a?.TE B?Y 0iMi!N c\72d ,Ӳ^Ǐt!H'Rδݿ'^x ٛ;IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBw0eX!eX/  UUUUU*:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩TU_Z#V?'U֨5T֩?TP꺪OR"HJTGKW[H֨?j @ $!! HB@AA HA@BBAA! HBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURJ* Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???nn$??`Z˿?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 27$PNG  IHDRc IDATxyTՙZziDYDΐ88y'&ɛLL&y5I@cAMA6ل{vUoTwWuU|?sέly$s|vs_8_`^n\O`KɦC/ aѬ[% \tQ?222PbY $ӜWZ< G"0?P]]c?鋄#,};w?BB,s'W;LK7BEt)R";w9KA~- X4sU!7{s잛~ZJKpoly'$oOm+a\J)%?ؑx/b&-UZFr޴,'X$?#PB )%AqnG]ũ:O$˸DJ!dqZT"[4!(EqdJ)MBFZi,'.zRZ:IYj RҳG -yp)..c燯rS#fFY4v@jy4=TWQ)EQTcJ$Aǒw?RSNjިaE-qEgO&@8mCU\l ` geԒH@JK<`S.OpԾI)ygO{$L<@QpnEva:c:`"eK#N"1L`ЗK3P$ŹdhztE\^z@s*$gORQSj%b )]>Hskbyz%|0PQ0% 藏[]44UEemTŅa[Ccł5Tו}ˉ>AwOBģi~g$`8*2MLSG7TԔR^U'e=?4&nhNt{R,^mM'j~@4.tS;?[]0ݚ2MLӤ_Oet=ǝy x^~NuhZg!piACS5S,./@#ug9PUM]gs忑vz ~k.lN *(Y:⽣`ŗP0Pr/ z1MfMLťhc& /8v霻Xt*L@gͰ;3ٔW6Q[JLib=yY}{n{EQx[{l[O?srT՝A iLܪe:>='cCp6UU&#_߶0uҝv{[NAOM9\nb$N9ح޵ųncLLN;˕ƥ*\?EunZwnYi›U$@ o_Q 4=tZvU8ť{)%o#; MA{\ޤ@~-pU aRJ ;?|t"?Ugذ.6IXj/yghg5jm_s^la- q6]M?ݓa Km|z^v:s2^|'}sBk_Vʈ%_h   p<)%#Li>Dr;>!1,=Ci!p® ,‚iY5|4PC&a{ĵq@`5tmw*2 1I+{G")9X$X<oAJISspݷy˰|)Pi҈A۲av[zO/ӥny{$\<UוO+7/ /eio4Fcˎ;v{8ytX&DR,n?;B ; Q˅UM|FfqǝNm9XW_MpAs^R›IK nk2 LD7s GQ\a譏sJC K>2si~ O!^|!p0BB 5~eh#*5V8ΪPajY,tHdԽhI*7&>K|R%e'-w`1!0uNz!bĊS>r-2b̙31a„&6qad < SgM$f]l]`5$ YΎiڮ4SXX{JtBE1v{ nW:nhq+gZ|9(\.^/Geܸq1 V.?rd\ @7d0l?~UVuxLg$m8s8ƀ4m@H@.;w2{f<4Ѵ`>䓔q뭷2`3w׸X}U(!h0xcIo2rn41 @sOHJ jzLu4MCuy<8vYeB]?HIiZs?6wkoSX0 E({~l,#χX<>YiL5F +B"tS'=6i=w~l(MMM477;Gss3wbQ<?jaI`3/]ъ'KqχغjKu|[ߊiFIJ8 j>NWymaӦ޽^L:%QZu/r7(ϞK܉Dr^+xaNDrϢ~ya[BAJS s?q+.: uW^y%.<l<ݵs[^]|,'pVhyN.<_.9^#0da}Gc͚5wŌ%F"69>)ＭfMLq\F?x?nRͰpa,l_W̸Yx>i#Hʏt7œ[qvA \pյ|sk9ffy3UUUCYb ,qBNj1Zpl|K i$˹O>wW"cɒ'>4Ffq,RFZNUayotx\gq7g-QwVWmKN~Gvv6/؂㝨 H~BqV-8Sd: SG7uoYw/'3_2555-[eCÇL t.yW#V{3-'}WJɵ4u^t-YIj<|%~Ö-["?tb\wu|(]go GuqDX'B١'cDJs}g?ϥG\`60h]<TTTDXظq#<G$ ,_h6~o#8ť{),GbЩQ$J$}g p0GYnӧOgܸq~y.7o<Əϸqx)<En\Es箘+$ooug4 |Bʜ$ q~MG3vX6ooto;m۶( f/Ycv()%ƀ8o!  NWH<_pBlݺv"FnqSힳt]F]2|8g?ҥ|OW4 N[N6ċVr쭸Mgk ː}oS+6=Q,qtn !_KYgE=Ij+V/zQնShw2unBX,q37,.H>Gy4^/wa別V4 nwL#Ubm׼d g9Sq‚im%+)%q#fޣ~  /=-aTU,KQ N<Or"?)sM e1gfʘ]>L~YzupmPJ~#465Ȃp9tSCӭ'>eE7(*BX_yw+)VDVFn@~sSS_yˁՃd}S/lxm(ssS6aqQy;0LG*n)%w<_;zd>IoyFEYI Ќ/DU}yP X^j]sBg+?z0^NY>Nzav}/ouT%!Ocfʨ+ɲCH$@]7.<#Xpοv'c_*$@Q7Jꨪ;CU홸-]3oJL`+&V{Bڽ0 LLG0F#Jo+)'F gD8PQYsg8W]JEMia(Ba֤N{C{ǜo@}w٣PQ Rv޴:|&\2F:@dw/\aI:3thƍ*bxHUQYyӽ* iJEQ:5(z ! 6 !kcEADZf/ ɄQݏk+((llj.CȽb+gY麛ť"#%ŸCBpPO}S-gNr$Ŋr*k: ͟v#cJ 8D'Iۚ;:<4 C#)D!ťVVDG]6 USIGRT[VRhFPklINrXPX0icasZf{9^y \M ،/HCSM7>Hx̾˃a6t-̢0 k|#7p4L`ZQ{l֮,Ľں;lH&ݛnh5Vp^zIESgIaJN)Mʫ>̮D lyn@ O5r53W?'+*jyo*J\x'ۼնߎn蘦eyLpPn"nx`;w&(]檹`/kڏ ۟q+-?< a(ٷ;SWW笁O581mEJǂ79ĥӞ'\7aĉIPs.,_/Zdx)Z>pNkLr(={)!yj4_;~qA<=e-/…n"sD"Mr_Jqb Ĕ+[~ %#7S9صk' "?^($4gX/o`y%`-p ?~ab WHi Ѵ~W;S|p޼HJLdKvF?Tͦ]~xPBCS5u>Ϸ"Å4kU@ׂF=" 1k-;.wwu3pn/B(:{A.!*kR# oR`Qxd'+#;t}ox7`$n!G:g@Tե^xG񤑝1~7[F_qH!'sORʨHzOB~ilA7+Zb[^]O)sŖ|44C7u'P" 4u)#~uMޣ}eW .$5g* } hzu+˦D7̞| '_4@Z(jmRVь @(-KΞ|-P9Ws:K# !;tulEkS^)yNMP4ʨΛ5PQk^Y{3.Rv;#4}v(ݮ4 4O}u֤k/k1FP ӏË8I깔t!A.鱅:Nk|ִIOJʊ4r Ѝ 19)qLWx,7UB52KeR”i膆4͈zK8!t#H0GQƏR<'1 Sn|5=@CS~9(,=!c UqQW_RoO IENDB`move=1000;blend=1000;1GZDH~iZV/O (~binding site for residue so4 a1555ac1 13HJBr0eX!eX,  UUUUTUEUETUUUUU@UUUUU:UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW eeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMjR֨?#jGUT֩TPI֩?ZEj_֩?HZZUTTR?U5GKW[H֨?j @ $!! HB@AA HA@BBAA! HBBb?WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUJUUUUUUUUUUUUUUUUUUUUUUUUUUU%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ Jubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1ubinding site for residue ca c 551cc6??1ubinding site for residue cl c 552cc7` 1ubinding site for residue cl c 553cc8 1ubinding site for residue cl c 555dc1Ht1ubinding site for residue ca d 551dc7??1ubinding site for residue ca d 552dc81ubinding site for residue ca d 553dc91ubinding site for residue cl d 554ec1`a1ubinding site for residue cl d 555ec2Ht1ubinding site for residue cl d 556ec3 1ubinding site for residue cl d 557ec41ubinding site for residue cl d 558ec51ubinding site for residue cl d 559ec6Z1ubinding site for residue cl d 560ec71~binding site for residue pg4 d 561ec8 13HJBB1p,f p,f EeeuU$GU@@V''E#IH֩?֠/uU$ԏj#uTkU֤kTQ֩?]UTGZ#(R?R? R?HZZU_R?UMj B! $H B!@ A?1 ]{ct$U,B f HB AUA 2""I$ T*I$U$AAUUPUUP"I$DDD! BIA$IUUT5B! %UU!H$! !UUUUUPUUP *"" !B$I$DDH$I$UUUUP5UAUIUUUI$JHBT! $JI!@ UUU%UTU$I*PUURI$JI"$ $I$DDHB$J IAUUUA! %UU!H$! !UUUUUUU@UUUUI$DDABUUURI$"I$$I$DDDI%UUUUT5P`5THUUUUUU$BBI$2%ubinding site for residue ca a 551ac1??1ubinding site for residue ca a 552ac21ubinding site for residue ca a 553ac31ubinding site for residue cl a 555ac5`a1ubinding site for residue cl a 556ac6Ht1ubinding site for residue cl a 557ac71ubinding site for residue cl a 559ac9 1ubinding site for residue cl a 560bc11ubinding site for residue cl a 561bc21~binding site for residue pg4 a 562bc3 1ubinding site for residue ca b 551bc4??1ubinding site for residue cl b 553bc6` 1ubinding site for residue cl b 554bc7 1ubinding site for residue cl b 555bc8Ht1ubinding site for residue cl b 556bc9  1ubinding site for residue cl b 557cc1il1ubinding site for residue cl b 558cc2IM1vbinding site for residue peg b 561cc5tu1?333333?333333?333333???????@???ss$??p] @@$@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 28)PNG  IHDRc IDATxyxWzUVˋ۲l/ٝl &dBIB%3.<3 f؆N0`„$$bljH޴X[KwչTu[kK,YrWwWsJwo_BGp.h!@ E(0l)>pͦ3t.g?_߫s4BzV7$dpj|bVQ^2]s_a1L!PFx" H0xHX"BHL&Hq8DD"NH`,|YC<%cJ38+_! 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