S!3.6-1h!/data/swissprot/ 3NZ2.pdbdupa 3ECT.pdb1[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Hexapeptide-Repeat Containing-Acetyltransferase Vca0836 Complexed With Acetyl Co Enzyme A From Vibrio Cholerae O1 Biovar Eltor[/h3] [p]Y.Kim, N.Maltseva, J.Hasseman, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3NZ2" target="blank"]3NZ2[/a] [small](deposited on 15-JUL-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3ECT.pdb3NZ2 a_3NZ2B1  3ECT3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i 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OMMx{xTs^IzM/y?iHo=]G1Tv_I:_ n (/ɚ DZ+>RFHr-':SΙ6f.<)S2jTx9Hrfs0Jmvnm]Ⱦiܱo'_Ǖ?odȉmouWv.{Β5:q.?+u=#̶u k|4U\RqcSZcp* ahcI,SdF@gn;ի9تl_Au;h,T75wrx>0+0 q1:E uaѸT}RLr 0o<`e2Qe?52(W% Q4 I7^'=Ђ fSkWRQ>|9ms7BWH7hoXwW昻9pcf$O5Ex,tt OAs7Bu /mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ?333333?333333?333333???????@???$??2`?e2@P@?ˊ?ˊ?ˊ??@@@x@x@ ???333333?333333???#~j????333333? 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Y0"Aa]N!Z}s}CoܯzH:<4y< e:vn>ZV#Krf)[($ujfPva5_5Z1R.:s?͇&8pࠆ64{%]G%UG{7kk;߀]8^a76Q&X^{@$&41eXI/D~zO=pS\>D'X;X:V9}#1eF5n6)sxeK8xWvkϡ{eԳ`MH ՟+Pg.ֈX{=Hx<<.D>w0zRTHS):YӮA=x$';JoÊ_iݮ Rd5~`v8~d?cfWƕad;P`\hI@a,qlX+G<%˯? {MsuJTS GR^uΉk ôfM͉p$fhNh/qȴ|"yE6S؇)aS$_ ԹOڤb ru?rxKFo]K{C?ΒieR]} STUVaɁGظwew&,cʀW}0%u#2:M[b2zp,~kf:1ibov8ҩ`MGC Ԥ,֨Kx<6سt3\!^lsLcytD]Yo7. , 6㑎-9vP]S3SZvx+^V2WMX"13>[,?D>qó s?(/7;$:ؕ q-,wٌ_([NlFr^6K6.s:ycdlDlG߹y5ܴVv}4u*sE|s"t㑯Xw=Fk#z]< p:U)7Zt}Fy"vl\Eg?~G77+{*s,"/WNo*}'Ryk'̛4u^O(r/~ (z1K{Wz]ڵkli-)|z;$=Ѳ%Μ'βkF.8w6>o҄ G;"Bl[+NI%z;Μ;w?Lsٰ!Ü}ofR عi5'v1;֮x%qzY"M̸z {W*'dsv9 GлxGIa+ܚ玤ERu:`ne/?}Ni@q>\<}Dz!.na=si~+?GIEUΜR ʅk'8y8-ڵfTVT3rMp,\,2 ?{]6M?Ѯ \Sioa_D"ׯ$ I)ٛޫ~gKwc}]0h:,Kg/]&f廯cعo&&CN,[MSmY8bY7X9|s"xIDyxFbj1;~[Or&D*ry)zͿooXu/DVwE!n]$(>HüABbgQ; \Sĕ2+]$ts)>يŀ ~/6ð8y_vQ7 g_G MTZ6@*@6TehE: n/(&^]C3)Hsd0(>(EWU떬cZSlᗴl _+W.Ǐ[*'WҞIQ~%\GJ?|6&ML Kᳱo`ddD :@s}V=9@'IઑW/jhpt6%:]m+w "le^j'^tV4穓$ub'G(g+XK5T(Ku;$N+ 2kꫯ7`%?z16VsU䗍ؽ]Ԃg)*#6g V{ѵPx%E3m)-mLC}jǝy 48ڗ='G,}_g$sAꙮ?X~3'eoi2^*.^2V rS h`tYC=3m{p`nk6Uv ׮|_Coadb53okUݶõWfj9{i"յf`@W9%on&{F_q(OKl] UjLJ1s?hx<Gcxj1t2VZ;J Ïy| M[ҎrܶAUQXH:{sj}p0ՋWHۍSȯWOC߫R>B=`iβ۵Hm:{ӋR"Sqe::qF-)S0b.?{u dS5OU"X+4A\|B>M9&6"=0&Sz&+p E?QcB[/rt;o x2O '/N1gRu:QQMP3a}]M%wÆyYQS n:eBI_Pg~ @<P3&7=XT:Zam+S5hho筠LZA{r~#ofNW;5݅yLLͯOs҅  zJC၄7i!<`6Xh-Ac6ÿe'j -mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1 $f $ WZjj֫UUU֫֫j֪jZ֫WZWZjUZZ֪j֫WU֪j֪j֫UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWfϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1?333333?333333?333333???????@???4,$??TKB@1E`W@?`\Q?`\Q?\Qz??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residues0PNG  IHDRc IDATx]w|TU'ez)dR&ɤH=44)v]W]uU~ kA"b B(p~aǛP Ĝɼs{{=6JW@m#݁V~UxZ銩UxZ銩UxqcepAV\zgEMG+]'TPN܇/$ n4Y<(^xp tOᥦ{h0Gڴ8 ':}MFRDvqxZm7l4]|IH ̼z$Tg@^Lx]L_4a9)71@x'$UHWlKB{t ,h̺^C`ʜ~ m)B2p^ZZ Z pgeK`"uϑ-ƽɺNK{°y_埑xg!w"P =F!$dgDhȐgB:̜uԏHKI"yliʔsʯ&|]#u- /RU\/1ޝ=;x=goe TR%&a]ajoiJJP>^?goZ3:)7xөpJK[@QJB)o_fMz߭sF_>,M`z_?'N@ h6: 8P[3~D8qb!Zݻb(<jhp8k CϽ|@w}OѸ|,ޠA+j94 W`XLv;]A()j߾esWQaa!D>O"%%&3?ɪWN7ś<} SSO LVc,B;هqLhOC;Ŭkf3fU={# I(,"uf'L&wz>˵MU3*(;B:ݸƺ?^r %X@))=ba¬}҇XyW{8eu*w3Iܮ8?ޏ ϥ`EMZe Fsm VZ Ȩޤ TUUMTHOJGHIXQ1gNK_SYWaRYʺn.|V9]4#.9o/iTҀʫNO/ h:>?/ #(=?TT&TA^o_*-D^oȐLl~Է/WVU.= H./F`EE1ef@?)_v?AJ%ct&^Նj|s,픕ͺ~!y~PA/U6=|@DzHN;lGT:c'=Ƽȿ՚,tp>@>BJO\|A9}: GJq]u^&d0r͍l0my8BVT ? bq05`"1uѥ 2(6]xe4rl*_?̙ -mKc3Vg/O+[R a~9 7`̘;1s|DhQ޶m9rZ[HJ˖1Ñ#A,-[TTN|YY6ne!jkwP(e˅(#As=轱cahР'Xi ;?>SFFu6u,*/Vt;o_FtM̤)/NJ+$ cSd$mx D6 K I3owMݻϧ#BCd4x;4p"L"f=* $ Ek^8y1V9>^y3v3GGƗn}vCBj[HH˦Iw+;ޤ>#Pt'nN $-YGf: lKRi&JKc닄έs#9WN/lԉ4e ct^Tt"$l3L}͘= 9$SFF** }c0i%mwRoq8cs1"i4p#4p$HUС/_}0UTp="!#Js_ɓlS>AVa#1xBZԏVD\l lޏ/QγbZ2[:ݐTCnsd4vٗկ/G*HiPG|JLK^}?K~*ߛd>J-c2U]Rog4߳N D(#c+gg?KBa)V?OJe5Fi`]'$4aL΃DR'kdTr΅L(O̳zޥ8%)j5J*39mpzq8^l55D6JK^uh8fC*-8e>IEE_0ll&٤TLOŴs;] Ba9쉲X|eV 9479r>5,+ي8(xJHC.(bj+hٲNR9([h\ko%%Mc<6VlS$&p:4} hVg`e,V0ڏeKjP*ؼy [ͺcHI[M6bӦbQWƂ P[ No b~|ݥ#طk?%p6q бr;wxؼytFW#L$3K_a^ ɣW(#Md,YI\U?lfk0d=3I..m[t%YdB99VCSC%'wGsG mjzl#Y#!/!,y AS4%x%K;>,zN?G!zKEvOdۧ2Odd\qzBFc͌wFb$&HSƩWd<8$Ra06R1h'ׇ[͊ӵ+cX4{_s5()aVU JKf3%::|p%=t' 4֍Sm71^JHCK5SC:K{ υNW@ryA>de"~m5<^JN~~K!1~YgfG6Xi| V >22I& ĉ#p$%TR223{6soL!\> ktN2YN;\KFc%9ᵽII\I n44ؗLƯ\aH6X&O+w@ݩ##EEĬBFWZ \!$FSJMAش9Թ3"SbMԧtr!ҘBl^٨p5%c"ǎ݀3gǩSqQ,]ZV[P06l mcAH\P*=ň$;˗ 77: !ttB>]wоkW@C^?v؋}>DTqއQT qq<,XP"^w)Q1ѯup1̰?iR!)(#TX4d0-\Q,rnm)s)?DVg5RI.g,Cmܙ3~uFﳐu5ZFSdDHS#A^Lp:> v~_/`ػwǙ3uoP[3g`))Րx9X"Zp5*U!TVB2YI$U&ct?_}5-:(9EHKΝ |ӱc y@v;ct21 x4F1g$/Lϱc4fSnOS^t4"F0#⧟C,.^?;V=<FA$GtFX뗖6{.֭"- ߏ;zdjO?= eN؎;ѣy7XG.+lYN?19K˱jUWtؾ}jk? ^Ngŗ_ގŽbÆ:z ڴ#?! }1oOcݺ=X_e7m̂[_N7 ~kFcç?`DbaO%AS9l<|yB!NV3c%$F_4d4jTHXT }ʺ#ϫ4 ,Ba߂4zx{XH !)kv#!5R^އTPz)%CH@Je2gHʧodkKJ&-@:7Vc :qt:3F3 knDzzCt[P8v̀{%Z6mh\hӆC6mXf&ŀw߽+t̙(ñsb־Eaf矙6o~`W޾}6n|?!5u֭['vԢ&̃  q>׿.|/_xq,_>l>d8pNC4Kc7@0NeCyq0rRX'rsEHJ:6sh. q:,Dz=^]Z|8.d!&JmX0Sן &=֯ 99a˖EHOǏp v-ɓLS@$J{1gob۶7 *vC6jMOC|9CIS+'6jbj0&λ.-]DK(; jsiڴfORp@A"x طmYxyhӦ:ugNb<7F8+B࡬l.-,Cbkp2P@QHOcUM NaZ߾tk_`Aht)- 3V 6[23ymڴڵ/v_~ya03㉰k*D|㰙_`ΝǠTEy+ :wF|+V0rXJ{e$N$`vgTW_l,ogc`_yϞS~(뽟t:6@fsgr&Ɍlj4J>GR|ߡl 7,)S>"'Dh'Oᵶv{ee ͰXDN'WZʜKWFO<яf٨LFNǽ sʔ"*-}4fK| I@_. 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Qϙ.3VSD-(/\#tFz T5iPfk+/%a˧aq$DD%'9s} ( 5q7D-3mpUL&/lY>U`P*3{jN^vW ` v4ڶj3"Q ص˂סv|, P__o[~>!jjv":ZۈrGRK^\\xs˳+fr#I z)''0fFvLI씗wDž`>Zm%D t_d\]RP +@ӧWp ^tm $JUBZmHn%vjC2>IZ-THr9!vng yLVg) k%ZͶ=hXi=H&D%74C|,hfL󍣔d4_=gl 7X@̙ukU2oF<^W d(::]fLlJՃO*U/H]P^͝EF#{4+k.kk|\k^xGFD7o0UV&K\|ʤqNR;ӈcX2+::dڠRNi&NbgfNAqqd1UT̍o hm <믝?V;H&Ig0B~7XGd$bcv#"*ʃX N8C"ɄV[ݻCGPݻ?p讦?5JHLxfdM.Hld2M'4SlJB gw+IENDB`move=1000;blend=1000;3NZ2EI AI  (" |ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/vn_ݰv?۶ňdvݷn#n_ݶŶݻlv_ ݱl ݰvݰalݱlvl/l/n_ݰ#ݰ avݶ,Gn#l[۶n_ݰamlXݶGݷn#n_IH %A$II$Q) HE EI( $JI"(PIH %A$II$Q@ HE EI( $JI"B$""$Q %$DRDRE@Q(PPQ A$(H@QH%$"$""$Q %$DRDR)!)A$$I)$""PIH %A$II$Q(PPQ A$(H@QI$J%"PIH %A$II$Q HE EI( $JI"(2   \hFȞ6BB h)$lkR6uWyPs7FFLU>$-+IV޵M@{IűN<|[iI"JiU$|E&ImB bT]VђbαXh8  &0PEF}һ.Z76MfQOK3(,F\D1RD!1X׵lRJ DmY.YXWB )Lk|"'#t .ωJI)oT {+ JpxY"0T$$‚ )GSfNjosR47;*>DbȮDS{M"1&T,LFF i#fCB5R(-Bɒ@ud=.5AS%4ZK-l>l&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1?333333?333333?333333???????@???,$$=?nX@VFB@?@J?@J?@Jy??@@@x@x@ ???333333?333333???#~j????333333? 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PjXB|e*uqn-ʞ%47Kt~\g͗9Fe#짡= "' cQBś(.Ь{2k7zK㪡DWkZ0!}&k& 1d6`AM͛>ْ׺ϓ' ָV^vipV9=bdd̛6}b,L3>W{Y}2q z2+++LN!6}.7N7YQ2uc.w]+6kg>~㴣<1}1Pˊ:3W2+WiU]sM,h qy C}Ο)}R{QDs=SĠ&{l!(,A!0%^8R4ZIZdt*'?GQ .]˱dOe5[78MB!.f#vPB~>,{r u bvJA 2].%lƥMU2"8_Y)u'~YX^?YqFSM.N@ODk?t| u  ֘ω-m̻&FE+B/}8b{' 3mī7\0 ib4O*jW#V^\yLŭik|%*"1i_O;hlhXqA6`6EDȢQ",0 "$l0$l0EEE6a26a",""dQDL( 0;aEXDE#a#aXDL(E2( 0,"F "FXԍ6`6EDȢQ",0 "$l0$l0EE6a26a",""dQDL( 0;aEXDE#a#aXDL(E2( 0,"F "FXaaEaQ#`##`a2(,"&EDȢ 0 0 `#a#aXDL(E2( 0,"F "FX#`##`a2(,"&EDȢ 0 0 aQ`#a#aXDL(E2( 0,"F "FXaEEE6a26a",""dQDL( 0;a#a#aXDL(E2( 0,"F "FXaa2   \hFȞ6BB h)$lkR6uWyPs7FFLU>$-+IV޵M@{IűN<|[iI"JiU$|E&ImB bT]VђbαXh8  &0PEF}һ.Z76MfQOK3(,F\D1RD!1X׵lRJ DmY.YXWB )Lk|"'#t .ωJI)oT {+ JpxY"0T$$‚ )GSfNjosR47;*>DbȮDS{M"1&T,LFF i#fCB5R(-Bɒ@ud=.5AS%4ZK-l>l&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1?333333?333333?333333???????@???*"$=?6G@?+@?*Ӥ?*Ӥ???@@@x@x@ ???333333?333333???#~j????333333? 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PjXB|e*uqn-ʞ%47Kt~\g͗9Fe#짡= "' cQBś(.Ь{2k7zK㪡DWkZ0!}&k& 1d6`AM͛>ْ׺ϓ' ָV^vipV9=bdd̛6}b,L3>W{Y}2q z2+++LN!6}.7N7YQ2uc.w]+6kg>~㴣<1}1Pˊ:3W2+WiU]sM,h qy C}Ο)}R{QDs=SĠ&{l!(,A!0%^8R4ZIZdt*'?GQ .]˱dOe5[78MB!.f#vPB~>,{r u bvJA 2].%lƥMU2"8_Y)u'~YX^?YqFSM.N@ODk?t| u  ֘ω-m̻&FE+B/}8b{' 3mī7\0 ib4O*jW#V^\yLŭik|%*"1i_O;hlhXqA6`6EDȢQ",0 "$l0$l0EEE6a26a",""dQDL( 0;aEXDE#a#aXDL(E2( 0,"F "FXԍ6`6EDȢQ",0 "$l0$l0EE6a26a",""dQDL( 0;aEXDE#a#aXDL(E2( 0,"F "FXaaEaQ#`##`a2(,"&EDȢ 0 0 `#a#aXDL(E2( 0,"F "FX#`##`a2(,"&EDȢ 0 0 aQ`#a#aXDL(E2( 0,"F "FXaEEE6a26a",""dQDL( 0;a#a#aXDL(E2( 0,"F "FXaa2  44# 9  (Rf5b&U.ąJ#UFyV&ID襈)Tsi"ԫl b$EI+ 6q0N2 2A][*QL.IQZ%SĄ'4ax A,"CჀ„MM 4ĢƒS)HTaX4B'%J'3'IUMԢʪ ! \V5jD!9LV d5 $=:1'04iZ4Wx 40* h xK-u]a%JnBrTqXD0<, `4*ye6jzQ L. jHejډ 6lEω#ZD$BpA py"C@@h(*8L5j3cjtNdM6YQIX!(r\$cXMaANKJ} t*irI)LƖDMf2NyuA 5*>9K(L!pX#I!pD@PP8閅)$֦TkVTJe5rmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@??+3ECTAfffL?p}/+3NZ2Afff333?p}/?$??.?E6)@@OL@?@k?@k?@k??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1sQPNG  IHDRc IDATx̽w|\յ=S4i{oV,rccc)$- !nB~$$$$pI@Hm{eɲlF#Ms?Hf>朽ik^{g-_Kgo8gϿ_+YOٴ:O;Oe!"u>U=eIϼ,_!(A}o D"CN˄^vD$$IBvJ)1$)_xJEѣT;BAf9 1< jK~NOͿ:Fxex}^ϽXFϼKcW|{ %W%3Y4*Z_)־rf[}H赑t7Rt*9y#J&5!}d$ AX2r F >rr$IDn\1A`8^Wy,8\Vb ( \n;CN+JCD-]5^a<9x00`o BEGo뢉Np`zK({Vo"1t5NZi:M.}h g&L@;4vBԠ葐$` րRq=HdTˎ ?歿k/nLnL.>7=VC̝~8фP8R!IYD/^݄(DG$^禱y|/|o|ekv]_>w==1Qx;NQZ ?|! 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Phh n T+@nn.\ @Z|.U( '+ڋY3m ڻ z܆Bo")|;Ѝ-Iĉ+@(wPTDc1ߡnI엞U뜜b'n:@sGT^[JOP 0 "6d 3&DcxX3]v;<|b8flG;[ud!9q_5\G]㯨f%Yr[ Wxrf2ŋ?󻨐1ljKAgOx.^Tr t#}***W\.Q]M1ktGǭȘO*GBda<cTr#*p /DJlj̢C! *peUC~B02: ;kWY6p4 r#}Д!|T; W B//Fuu58>Cy^o } x(~L@ssH ,l/Ahh"inFOo4> SK,safbdt 7Ѕ6 vo}|l3Uy/4e 5\u/eii] >namh?lv,٦U7xǐR"e ceQyTb(v-azD .W[& YaRCxeHM=zCC*R9+K\2x5>&?J;NmcH& aص064) MaddLMFً?I<(Kf|38V.`#zT &8*'bW4nbc:- 2YG}MQ^F0a ##a tƄ& ߖXaa:k sXd.<$G!,%넾,xbWrlD@2a/4XYڤ)wMeJ+2|[Ē̅/`8:9\4 *@i%d$5Qm/B#gd @v 6=A"g$ {.+o^ki^.!CG vjmܸQ{+J Hr$KJJ H;)-ɭd@N9W,| QA$oʋEOѣGD+s0Y* 2 B?Z"Y* /TPHMM+;{-3% ƣ4;\cQWíXZs+k}:MB{E= %始#%v-L-`@0:0zCJc0F(?XY:DTP*|p۝Q2N<,h"w쾂Q5T(,Q]3fڣJDN064!F@ Ey*Lr =.QssY=O)UHܹde")OB1"W@@2*BU$VuoM0k.\왢x@ONnRs5 |8J?~MЋڵK0I7w@o2m:ݠ-; &;`S֫[[_u`j[ -qr"ILx&iz3N0-qbif "73NfʹCc}wC/'ffݙn'D0+OC}3N%h'C>d%nZ<@L @gu(t8֗G - amse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???*"$??@z5$I@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? 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yEdOuL ퟽!b1֎4/ \Yeθ^f&an|i%7} Y!Ɲ[u +%seWp,bSϡOPdeI~Dm3A(-m[l+ʈ JLge;;/!!6*$x?uyr*jK:Ѱ ŰqcOKʇ;艽Tח;ѹ0@vVP@a׋6D=Z ex8alBfaY) ðL/f\ M鱊Ϩo$s|Gd&$ h l]1v P^޶T8MBhzz݇7+~㨪-K/}2ȷUuD*(Jjb.-FΞ}%/[E'.b?۰*)[?"sħ9HNHnF3¸UE +șTnόm.)B1@s˧BFo'*J?l0G;b/ ,/DJb6z]>4YeWQ>wq>$ CXN b7m P{ M s:̢?B3;a``Mp).Ba?!-@SK M RMb\s&_ħ?4TB\GHO0 r9}mޏ=FXS;#kXK$vE xIN9IItX,q0 "zQ}z8to!XsOr}mn'Dyb$z3mj%;Uŋn [鉽gMrG!K2Xa!r/>LuiS!n&ۇ#eLa!FL!'}|mebȭ)/c$flIENDB`move=1000;blend=1000;3NZ2@I AI  UUUUUUUU_U_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU ,0(9  |ee A/jTUB!QTG!֪WZP_j EQEPTQ*!QT(C//T?ZP_֠֠/j j P_j Z?֨PZխQ jP/jZBjխQ֠֠A/T?֨!֨Zj j T*j֋j ABAAGZZT?ZC֠֠j A/j j Zj!֡PZZ֠QT(CQj֨P_P_BD"DI"D$ $I$D$@ DDI!$I"H""$$$"DH" DDH $BH BIHI DD""DI$D$$D$@ DDI!$I"H""$$$"DH" DDH $BH D"I$D$$"DH" DDH $BH  $!!$H$@$$BID$@ DDI!$I"H$@ DDI!$I"I$D"BBIHI DD""DI$D$!!$$$""D"$DI"@H$H22WfW#'?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???1)$??ȶ3*@t[L@? ê? ê? ê??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3x*PNG  IHDRc IDATxw|՝3].ɒ{Ls@BhH…r$ $48@ Plqq,[+m/3shWZV~k;ޛo_'*@9EGe?}`2f."/g<>k{sS0L+)l<3lAGD "amGNV!*0.UUQQPEUP?EAQc)dTUѯQU @u[#{Q߲b-Fom]eKK#;:9PNA`/z*H*Aϰ @G ZZg*DC~kU{3v6 {;G q?B^v1;?NZԒrO:1&T<c/⹷W# "(!Hٜ-U L*A 襮yh7oHoty;ȱ&fjU݊l'/%mOKc]XLYdr1l*=+_s:;=i{8#‘ &*D22b7Zk#7u} ij?D Kcf[Yi'xx.!ag}?(?75;iu8G\anj7v t1tq ԒnʐSxZ':HyӖ&a;͎Z!EqJM.>'ig$PQi2d/ZClE}<~8: {:1Yym<ՓNfVhCpt]e'n֗T7T'S;qqM~EUmBd&>p+J_Ӎ&܂KW>u&-]qA O}^[CDUqM"@l$ P'*4B_wIsGFلyLGC> t_Y߲x)58{Ӻ|}U X:O+Y5*݆ϣ!Oݸ(/p߉P86#TW꽍D_י*Ey%=jyWUUmDJ6g=jt`v:: dg K?Nc9[**귍vR&%ij?}gW+]v!Wk;_`t&@sL,(tG3)kzEaTm@0K9F|.HW Pcaa+֮@WSS:P L s2so{5?z"?g|aDYigsrRhw5y8G*;S0d!j7#򑟝Oo=7tEh/t]&(rPaKQ~z&Dd]8ɲꮠAQ6g5,uų?A-Zw쬂\0^pdڪG@r;f =ty]x]>ZA9X4cLWn sWy!_A ^%Z;da#hQ˸Rn](L?'j~+9D"#gCRU%j)Gɱm͏FPU=֮6 qm^YT6aYl<ϫ> B@ȋ?srq`=*b qLP9n y7-"&.G@r" ,z <&$/{{(f|VsN+E+υg|p$/'_'}%z;GEW\&$@^sY46\V5 oBM%$IBE.=6.Y]&O6AbV}sFCTç..UF]bڜI u[iw6 @ "=0+W|~i3&@>"Noq'|, s'!=w4Ax]U_$T&xR{;{9~֥ \x.]tl!D}#jd%dCh#N9v%S&#˚ yK^p˕EpMx4 5ޯiq.H ߼8Nd9BᝣݶTtHY߁{Ut CVX45'x v"s%#DLb-ZDèE56NC.($#b?qHo.0tiߢ8,}I]5Nk/y;`ϙ$y(JLhړ`Uoq>$AX]_Iu}eL]Tvڍ)PK?6!(2EcUbX-f IETnQfraQըYLF+&5}Й*}v( 9u@[,V,+VՊljsiqip@,GQ55ܓ`WAQdm}ûp{}5/ aZX-XV_ʑWgW3d[.f㎿Tpl[l`d:(8;%jUKpb#Je Էӆ(J60՟UHM.}EF*#v =B>fU:!Չ<9,G5Ą3n)Rsв9(}vP\P(AdEEV1P-?&0؄st(OZ/7m!7Bw~ 4'yb0Vvp遪+l ͗w5ЗM͜ nj`A܄#$EԤ}7{w ݎp[5M\|\8!?˛v1L%zp g._os׼hF-z\cr+oޣǠ}_ygiW w Sj7-ZuMVM-H||[ }maÆ˹[cÆ |o[@{N~d13Af% _;S Fh9f˄ Fu]I4rU\{!F hKIF(IDM }n&e2cAD09$Piр$Eʱ,VFUDAL"+=4шݖGu}%n~^uCa!=~h0=/RveJ"kNZfcd#+2d 1̛J>^Ϫ/@ffɯQ _Ow"[OQ˸ƺ1,?R0>(/&<{1b42gW3v,]zT*歠b }/jtт`(07XKmU1__s5ʏcN:$*++q:n HByD6n4KXv] L>KN̦,}z5`Ln"cR7)4jf!˚/D{mgz,u3ض)7ZU‘ fEϴ5)&@v["Y;iRE7oUUUX,Flg͚X-v"tU%,zF+,.'rqt'!dW{7D(q +yWv򩨬ݲfXtYh]^^N}x}OoN~Ϟ=g|"[Ur;>aI\zŅȲ̟a˱ˠGE\C " |C>="b|r 8VpF q•v0{fks⨡n[.?;N_r O  -A,5޿Ё^xe͛G^h`3^B9*DŜ_[ίݲCty:Ȳ*ѢE~{j;{68CMԞjp\6(*`1tkJQ6 6Mo^= ZxbKe=_p,8MDH$ĢTmYOGa]7~PyGL>8 @Ž);w¡6pV,&S'-ңj ښz])) h! bvD(&5B^A`0Q2nf4n^znzp_.|KEx"yyyڋ9PClTmeǁ̙39\=v2Mj<>g\|YZ[{rqs zQW4 Y;$NvXOggE/[8^}u?2[@,X%j(BQ̳~uΧTTr_]zP( /nu0b=cEy%\qawRGû^-c XLvQ$ۖMf;v[>9,y*[}>3_=nP#C&o>'x.Un̲SPRV*?H{œٴ}Zijbɒ2&o :EJ9sg-cDa1R4u8V9s#tzL?C3vi%jL7zZY4e(zp~09Ȳ0[imFqy9C{F f׮]l9Le'dbƍٳ,XɳijjwٸQ)\PTeee2SNF9duQCX۝6xNVXѧŽ?,YfJ֮e̜9 9s8]8O~~>viiio |$XAp?Gcb;0L_xMND$TAK=[8o2%+///.G}w~d<|=:vzz\y0lL )q?_UUUUUh K'Ν<Uzn` 3k0VXM|6W&.nZ`@}Ix*zmz.?qe%&}$lKtٸ-fO9d~m/G GVaL=3OaǁuVdU g<'&!7x|{Y< lzj֮]ƍ9{6jȲ:#st (حymy.Hv=\֨L+9} %a6α g<gvi]V.xD袋hooh9IaC=e UL8s_/Mw 3IDATOϫ>2;25v |G, 'QjO`n7ހegq.rmvԙ F~k7q@Kɸ#Ҩ;j{%| 1A?.8>0b^xᅌ [@nV9Y~0퍺/bR}%ߖL G} 6?Rh!ISGs+:ƴK ԅz(0gLɋ9vKav8-qZ}'dU%g1|fz?.Xα]hAq3+ϾGe&EYrTٞ/ oTg}z"NUVq¿]ZޕOAfM[,Kn\pO?ޤ*o}@?Ν;GǠP-& `('Ȍ}_uZ~h"H?_{}ݿ{֭[7lmWSuf΄©x, ۖϯao` 4 t*ΣM?Q@М>! 1GY/P73 zcXM{a0p+ !"QUTQsL \s^=©zB&P0EKU 7nDWz64ɉ{̐Co$ 0xM=1-W(@V"*#89DWWf5Ä"ABCݻB>A/`G87}|rbA4Cy$mGENC~F+ h00E y,ó1m s{0q L'g^ Zx$I;U߆$E Sٿ^D?}b>?+))>K܆&Ow3π z2Fr}5hs6P۴ڦ|hڋQUe.H[)*J۰ask3 AN;28jز]Yesoڍ b絟u,J#TE% uc< ~oWVX԰U:aIˌJt׬'DBKC_Z zz9QnƖFY"G}i\~g޴eA{# 0~x{W C橓 x FCj555ۨ S|q3ny7iNHžCw}7-N#IS+V2h*'F Gʐ^ '_5@iF QDDD^?|GFv9nN~#rߤI#MmnAd1Ղ`W/\]L s+5zPU9#6K6&ܝ UV"ZH@C 1Tp}ET,(o* ۖ/7)S>d'i;O"Ð1uRf_2XYr0x(# "+a"r9" b`3Jc6_J~x 0<wƉ`R ?/2FN-)8gPQQT˄B3Jg/({!ٶBrC ;2i)! :8(]`0wyZoTP$_ΕatjhFbNm,$[pg'՜(HTDoUƤd8:Ȍ R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R&#<R=?aIENDB`move=1000;blend=1000;3NZ2?I AI  UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU ,UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP(- |ee l/n_[m-ȶ_ݰ llضll ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/vn_ݰv?۶ňdvݷn#n_ݶŶݻlv_ ݱl ݰvݰalݱlvl/l/n_ݰ#ݰ avݶ,Gn#l[۶n_ݰamlXݶGݷn#n_IH %A$II$Q) HE EI( $JI"(PIH %A$II$Q@ HE EI( $JI"B$""$Q %$DRDRE@Q(PPQ A$(H@QH%$"$""$Q %$DRDR)!)A$$I)$""PIH %A$II$Q(PPQ A$(H@QI$J%"PIH %A$II$Q HE EI( $JI"(2,Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???ld$??$@@J@?ڥ?ڥ?ڥ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4[UPNG  IHDRc IDATxwxչ?eY-˽j8Pr!%P)667lE{eJbs& j5ݺ˗^CCK%\ T߮#Äع  IEEEhu$R!R)mmEDe]> ryh5h[:5$Tڐ[1qI O|)(? & !"d)*g~As[ Q!)l[G:y6V$9 Ϋu]DJ *g#1hB]<Ɗ'Ya'{{ޑ+?+Ce01n!Ɨy_CBD@pFd2" lm9D#JwZ2}+"EW#󾍯 I"?nPO #ލRڎ+Sk;ihɋ+t*֎:K1tkڙ?y &nL7Vc "i,=IOEm.Nx#"$"F5{GuAGU||{{Q2`猗?ueW\AqU +6{mŠPP~>m+ojBD&'.۰!c40LLXRBPa0o)ִu!vNL_HlAMBD qYj$I H8zAqe&N7lu.4'#k/]Ml[G~h3>z7/-FhfZ*MިE$խQ\V՚m(6Lƫ?e'7ڪo~QQޠ%7DIFi^Q=r߭d2T*'UH&T*[n4U[_IIET*;\~ +䅿wgEŕe/%Վ7lL~#"8;]޳|ݘLF_xie?$ 5Yܾ!qvtG! 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"D"D@$"H$$$"DH" DDH $BH D2?WWfW #H"?#H꠪&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???x$??$@ G@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5KPNG  IHDRc IDATxw|\ŹgzW[ݽWm `Z6 %&!7! 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"D"D@$"H$"BBIHI DD""DI$D$$HHBBH"$H""I$H!$!$$$""D"$DI"@H"BBIHI DD""DI$D$$HHBBH"$H""I$H!$"D$"HBBH"$H""I$H!$$@ DDI!$I"BBIHI DD""DI$D$$DBBIHI DD""DI$D$$"DI!!$$$""D"$DI"@HBD"DI"D$ $I$28WW Wf#g?AUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$K?wl9GHINL'-;! lkFPG[%gYuao rmDV<wORB;Ғ;.3I iHȼ30f31u]r'3~ k[k'WLu53oz<5δ8t %!!$$$>So7έV*<-@͓"Z_ucLy@lVGO쪓9i-^|>o/:F]^;躿E{Q+}Ⱦ"7Ei'.s!dYAU-XV6{o[W?^ MaXPUKD:&OH2~`'vb&qS?j;/EVYP]6aB} C[!\9n|ߔH??2/0 #rDb"ېeY|} a Uj6 $ -Np àG0D8Yp+3c$l“G[W^kfOįٜj!S'Oc:q?Eڦc:бZ-~sÞ,!3{ DlӐg P<7z]cx.wm$tԀ | /:G}[H,?˯?YHLbB$g!jn&#I{2!ި)*WU%Lֵ:aYf3_ wS  8jw zeYGr2m>$3c$E_ŏ~3HI@h=>Аd@ E |_FrS-WxTՊ$ɜ ! 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"D"D@$"H$$@ DDI!$I"H $!!$H$@$$BID"DDHHI! "D"D@$"H$$DHHI! "D"D@$"H$HBBH"$H""I$H!$ $!!$H$@$$BID $!!$H$@$$BIDH$D$@ DDI!$I"BBIHI DD""DI$D$$H2,Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???ʼn$??,@ -r0`fNS@?Ŋ?Ŋ?Ŋ??@@@x@x@ ???333333?333333???#~j????333333? 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,ogh~o[X&MpdYfN2:{k OxXv-g}6˾ o?s$t:e/)w*{Bx=|^?Bn$ь4G*d,.r^=t|>@H${Z[[immeż-މ qGHHd:$@:N1O>o& 'z#hK1u{^xa^>OIZG@Xc/_k6hZ!I"숷e?K?s=~x>lV6iycm,sFeKdw03tEd:e I2աz<6ݓ_φāc~i>z)6o 7… j3J Vyg}>jL0ZLyucq㖯+;{"n$w_fzx RTzttt~:sw&Ii @?`<]:Ɉf |81KLS'OuuЉɚS|O*O[zYfp%Kp(E}!*V\ɖ-[Ҟɲ`i˳ c1,^G}z;?>ڻGbC6P˷򩧞_ f͚QiC7RbժUG&VB0q ֭c۶m~LJXr5l3*nMY$qFuggoΛ[J472(qBZ=FJ菏8ğ[~ם!?_bK]۷oh4O~"F͛ѨX2LA4*9$??*I+bdA}l"N}%v*{ot>gM7x0MsL "*g,# ~MJxz ŃxG %_,.7bWƺ!WmUuW<"͊%+2+ wgZL 2YȒzQ^O_E8PK(P#_#4eh "ю+e˖ضeYXmضJ⊊&K@}u3F7$Ru:82G GR[H}0?r/>_TG;#y"6m4dbE_ όÝ\`5$P3fjakǢih"ia.) U|Llyw&d3cAxzQwwd:'Rw3iP#fSq$ނN=ܵ|y,:rz H9D$ց'w|hw'ۤT\NigZw5z#D=fip O'wOr+?~4sNemNJKFЍ\jl{9&w[O9>+2uLx?5Kta~)$Ie9d E)~㹮ǦT5fr(X|TWöG]Y=^ub `^Ӳw5L GӓlTN3m X0]I(PêeI{s{o`JX`xM4#nY)ft} SW\{2w%gF@ @-rbCa&q,yS.CahyM˩ vtq3V.˩?o֣oghF\u^Z+}yv'U6o֒3M#FYAR n+05 yضpY Y+"k__hG3R$3^Xz0@d2E~kv1P,´̂^٭#ԯ`Vac#;}.7;xoAidI%ހ?H$LZu"ϫf-QsCKe88r}'x^t#aݗv,ltdZs,{# S 052OYt@ H*Q&:Ǣg7>K珽9;pB~7A8NB۶ЍSXFS?8<2D.MwKK>~o?H$nCrݗ:+(>㔥:wx U} ϋ{qN_`UQIӓuȤ$}'#"r6 YahF G8xʦyoĺؚBJrjCD$Gi4k{EQsDGь$cc 3Oyo꒗o$p&ײ)|_1ϏD;ʹ.Z#  7PXNQ!V<,K.($e :lFrwVJiq=t;rDzԸ wC2Xĵ> gT"E33p$giL/x ōέ(BHzx2;hF@45ғC&r}UMI7j$ACp٬g+F#w/eu|ATg adYlD? 7OQc٧j}Ԇj£ؼzY ]q jQ|}tEر8b I8g%YPq'rTŃ")Z*7Q}x=>TՇl>+b^^j5(.Sx=> CôMpP G8ēOPI/#qn*)ϼSh[ ?։"+xT/$9cT71"+EyXw עib>ZBZZ՗)MV|T T yȲ#TsRa\ENYt6erp ؎EZK* z%d{Y0OĻ^`5@;@ `-Au&Å"+8CWH(27/)ev.q,TKSe\dIGpc]UFѳMJŃ,+Hazr!7㼦S,h$%IReH/#cMDuᠪ^Yn']m+'(je`;ṉ#GPNcHҠ+Xtoqe(HnL>f4ڻ2i9~3k e˼$i0LwX7/Bǒ}8b00}vC B TŃz25-Hj}WUQ%̒GW'O+ہGQoYr<;m\u9;َ,+|H   VQ_=cz7 b#H4#ɬ<~Ͻ)kWZ<zݟMSsf c"v l7|cE!|hzex4''7*{z|(#c?9Ē%oEgTWL_qLW.o44= m(9dj4vUP#(/幭 ЇrYsXYǯ 8 &''AQU05f##d 8| GwNy4#/+[aRg'Cp6{ȊBMxO>;wEQ| MMA8c/O$M8HBLJ%yeZZ"ю~,̿=UsG!:P3 M-`ըpd>枟LooI{طg<t@UQz̪O8PM|["'2c  ջKMEL`-m M<ҧM1wpWȒg]{M Mꫣ.?SyΝ_@OEFCxBBJ9DS݂Iŭ`ڍ0~o0mT !Pug|9lDS-/Њ2/+X'x'w1$c2 %' 4Na+;4֕gBx}tGH8lk&my?sN'ށ#%|n%Hl&ce}qhDAF^%Y"!诞F/K+msI?概 7BP;b_64#I]U%%c\ #ͬĒ#|>V@J-!R@5UFUQ5,_x6o_|tBIENDB`move=1000;blend=1000;3NZ2?I AI  ꪪU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW ,?ꪪ(. |ee l/n_ml/v- ۶n_delcn[--l/n_ ݰ- a۶ ۶n'vرlnݶFݷl[ݰ avn'vرln۶dݰ avl[dn#mvݻl۶avvm۶l/vűl/v۶vmvű ݰݰavlvl/ vرlݱlna۶vݶOb?vvݻl۶a$""$Q %$DRDRDJ)!)A$$I)$""R(B$""$Q %$DRDR)!)A$$I)$""R%  QDH$EIH )QDBBDJ(IH)")E"(D QDH$EIH (PPQ A$(H@QB$""$Q %$DRDRDBBDJ(IH)")E$(B$""$Q %$DRDR)!)A$$I)$""R(2,Wf#?ꪪ&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???ZR$??j#@@ WQ@?L?L?L??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8VOPNG  IHDRc IDATxwTl_*E c-j414c%XQ=XQTPz.l=?;[efNξ}yW ?  6\䑋:Zn8Nk`Ŧ[R$ nkj 4=$1 |tԢ3t뷽2Q9vd9NE͞{3 dVk?Qxy˿AgPA'֜c}b\:Q3lk=ΔQ7#浏{m6s' >VG sb@X=uk3kZs z>ѠZG#7YinVWrycS=J)J,dP@>+XΨ2 5^$qN" z ֈ^kD{=frB{5U3h2S_+@2 95F"2G"!!2 py؝ۏpt#Ȳ!Ʌ ͙[5"΄VC!@ P5 I IZJ?9jtv&)6r\8\HxK q1)Ě9Zto߃:\h5ZۏlrLz @ڽ>l %P5N7˖V##@dCk5:d!6kih=0/Jz8T*5*IMjbU~hpm 2Sm,pq1)^Z;d8VO9V!2 ~{qR@h hPqVrVk7W򯵿Zo4XШuf۪wo0cMHD!ޜ @%?~Y9;nc!HIVkOeKRIì_RpL\EȽQKB\:lZ{Q Ix>/vgiIy$cs*ˡ$Ih5FdُkG QOU?HuA<>7ɣ1fo&IR)G7t,o{άki騥ф uڧ̔BNz{6JC9 's p1͘ 21$:BcJutY1mȀXObhj;FZ\G.*yU7-)m>Pڦ# ͙kYoM%01.CY^@@R [tMPTBZRQQE38g56>b)/$&Ih"9aȀ;rϻ6nGR\LZ;hc7#{J8C26g+ml޷zn*{J?P!SxZ HB}QZ8oOzl;O D_Ѩ™d?MU ޒ%ޒŤpҪfc˖@ }#U8cP}+k eeΤU2?y8屣יv>T I UjE%u;F?RZ˴1Kr[ߏzG(wt rr +> ^fĨ`1% -hڨ*1I&dSV3\V=I1%dtؚm kP:9NeB8 Ix}nV6n. 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,TA衳h  }:Nsg2bD:{.~sxxj>ɥW P8RQkѨuM ړ$ !Հ1R.'=EТ/}@чu қ[כ6[j!}'%q>p5@H 99{7asgwn߭)7U4PսC-~n*f'pO F^eތ\;I-SGV䬋t:%ϞZ la{ o2{47tԍ/^@؅(S`pC$>>c(CN\~K22VSeaX|.AX ǚYx?`Է$sfJ 9jB> r6:iFj /pwyU@RvYU\P]mfa7HX3?/8ȈswsWf9?H6D2!29yEm~ٲV=[Fyʳ*̆u> ǚoO3累[1"=P(AAVDAd?aw?譬6d7ss R#ѳ֢93"pn[,i.@Pۇg"hE(`<ծ6:#}Y̲Z)ExF N7nΨ$^.Zv_j 1Puz7% g:)CXI& <Ar/*"imka߾}VcuU\dYBо6oІ?`r&by̳/Jog!a'FCv/A]S,ƧVG8~AD- %6mALm̾');P| إN?@OހZ.?Pz`0"Ivם`|:[WS.r‚xeEoZpz6+JҲ$%H&$D)|A;ϗSS8kbx@Tkrᚊ񔉺IM7kfme:F$Lecgwne7-" oDrkO_6=!2չ½?GK/CE!vmq)M:28(ޠY ֩{x6"5sQJv_#IKIU~SqBHrʴU".6x0X\ wov&S33g..˷P93oyDC5Uj;7%#lID 6'{A:ZNb4gDZʱ{'_~WɞҮ_b1<΋Yۇ5cmd(mMݬ[gy7s8w0[_12h:N]1@;TVk@׉ޏaFf.F\9u !F3=hl{ӷٰ//^4D<([ede*YN.Y]H2d_NMM }5w~ĝ?fmҒ/W^ U/ģ=]lD" v OKԨOH]655_?x,F<'i[d:"K|<09Qp3P#N}QkAְ{}/b<`FHe)+y徢s2H$M"+|pLJ>' <=?o@ ڹu\k8\x1<~+cKmmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???֚$??A@)@fQ@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 98PNG  IHDRc 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N؈8LF%IJd2^ŚV<IRV~DH5ok_HGϮ[@FI",QWJp"nG\wu9[,Xd4>#= [f@™//  (d2J}Q3wDPװzi(grӾ%(K tx* ˯ G g |X:r=* s[`-5s\E+kK8wEkPn@08&Zf9(IzQ4+|> 9Lc줻f*kֹTbIA`X6tȃELxGbIK0 O`H?㘡Bvc9 'a{= h~_8H&vm Jp6w7*7Y~>*+Mɘɘڔy7%s % رgm52ٿ̤1q5Mح xr!eI- )j4bz3|,]z6wy'6\`j7N$%,"zx۬,mg$Tzx/N5V4sל:eDQGC1Y g+|8?X>;Fk׾|"dQGvU5-Ϳ {@VҤq T nuf'9%-B<' K$w n&wlM 2+o|mgk_}V.sυ;q[`عs,Lw-3E :*ߌ]c&M53<yGeÈM74f?>cJ&Y lo0L|y # ,plk!e HHZ"pX$φ Xv-Ge<^nƢ|ѩf2S=T*e%+Yz2%͒[Űu50A7D*J*CÔe *qnFc%|&_q׃>=\0֭[gzE\x֭[}%=*.5N_8czcV2Ӯ4>ts%am %y~GLI bW9w}O]iڙZTo~<qB+XMcDQ18(P[԰m뮻;xlDóZl.­*} d}GhEme (N )XyabTU0*:d3z;WG;jPY?9Ϟ{r wc PWْu+ 2US~bwHzzzzJCfxWR*s/o>^{5瞲{ `@W`?MV6{cB%,"O`(H8^I%IDʯVd;R_JIEdI Kj򄚶,Xuo8.]3h ׆b08|@(Xh/hy&!ȃw.DvBp"a?*ynlX"H4D3hA:YVX$+uj=oHE[](j:L`EZ^=)٭NADU3)'yp0P3 PGxt65:GiiHCDB]$يaEڲ x2UI2Ct]bh9>4~-XkJ )"OzKpflwfNLm #lĒlssCniM!PW ,B>b "VV-\w\Pkf0 !2K;fZK6 6Tό< m;$*f0nUabN7[3ݜ+M2\T<ٚ6I?؁nhXd+.yƢʉP݋]M0C:f5j(I Xb(#d?{Ipd2U /ATͫkZYmt Ux:@-yju02weɊc5cF$#">w ^R(6Lu wJkEtFI3 Jt@7@*VU#Uda,3l& X|N LXH<{6Px2bY\xɴNcT$ $ 3po/`^% h MTaPT0f3^Lw%l [ B$;YmJD*$Y4 YP LU0SgMS qRRI"Mrћ$ej|>)}ZiA ؉kX-6NTp͍YCe,dO]j dL<^w5 ᰹O,Yn,f([G}U+.X2ij5cڢNUz =11UU09o)VF/nΊm^g%p{ q<_]x8L86EEt]8p'ʽ3." ̤InN' [s5& zx}b}X,v̴֯@dt]pR'}y|羿` eIOM<h/dⳮq8^DQFΌ}R#&|afٍˆ!Nas0X4:zIbXx]pdQ"ې$ h%ʍԴU|EBHo"cH0>?O'ʷWD2L$>@2#tt&P)3yݡ:vUNug>fus4a{ٱg㴎%7,)3!V4`e0~sq@'˴;ēa]7>H$6pHa<{ju{^ @ d=|=㵉[ $7x8.P%s/koV *uh7 āSgҨU yrG7UőSg3P;OiPS9{;pjښWҌ Ky{) 1lhl{7i) 5s@AY3u&W|uK"OP_= yBlCW`ICS)3*[K2VʼnS&T y-+% IxXmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???7/$??F`?H@? \? \? \??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10-OPNG  IHDRc IDATxwxTe?S{' )@Hhw `_kY+uW]DQTz$$L&y83gf2 :dS=yeaBp@ytIȐQTqi۟ܭ @ d2oqq~ $3xӝ;s ͊fe`Q~:sc  Pm ΘN8VK/"llV+ 2dd2Fgpޏ<ܷlޜٙƉUQ)\<&r jHIG 0e"tB.o2s6k 타@i)cb^jދ9]0˟Oy=?8!/ȡQUuVJ'+k*?(e, 39~fUO#B܌}A#_x KjK -4oǠɣ 6iUh?+Q(|P(TZ :VE<NzW0i! 29r)\ &MGiTUq'Z*h1 y3G쫁Ύ̜1Sdr295sHC'6bx^ Eaa=ˁ](K@$]{ @\T  r 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"gb21$Ǐ!#5d^ym`ALcRqCv2ul4M:vHDn'FL;.*BU4]x/uUf`YV@M@LGw#$)߃ ƢYkFbHKGHLgW -T֝ⓣ;=ᒔ0;Z$zW'Py]IENDB`move=1000;blend=1000;3NZ2>@I AI  ꪿UUUUUUUUUUU_U꪿UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU .| OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU(V  |ee A/jj j T*֠AABZA/U¢¢PE_** D*?** *( T ZP_B?֭jkWZC֠֠QU *(TQ CTU𨨇E_QQE**/jZBjխQ֠֠A/T?֨!֨Zj j T*j֋j ABAAGZZT?ZC֠֠j A/j j Zj!֡PZZ֠QT(CQj֨P_P_BD"DI"D$ $I$D$@ DDI!$I"H""$$$"DH" DDH $BH BIHI DD""DI$D$$D$@ DDI!$I"H""$$$"DH" DDH $BH D"I$D$$"DH" DDH $BH  $!!$H$@$$BID$@ DDI!$I"H$@ DDI!$I"I$D"BBIHI DD""DI$D$!!$$$""D"$DI"@H$H2>W%W Wf#?O&3gꪪ&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??XC?6%B@?(?(?(??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11!PNG  IHDRc IDATxy\Uw-dH jP'%#+2,Ό0* +*#B @H `B=IgUt^K'u=OUl9ϑA9!  BQsc00i"$(o82w) -*%7l{>6kcZI0s CT"1|-.IHȒ/lIeb:ysi'(}4Q?hm#))3Wsڙ`8@0@e,}iǢ(Z0z.'*զdI<5!"l Dsk-XV5bf!*$sٔWO= M Vqgr̅)m,` Ą cH8NN8l9!$U=t2υHY)1݋{nm"HRDNIIRUw ߍ$uRB]iu4jk$rmVa㗘'HHfM*˛3{f898h?kZhOQHrEd; pزN!?wtz3st"}!S4BMC\XnO/uiiUHUV|nRdeueAbgI.`԰)/caQ<5 =ng۞WRnCW2lG>vk6Kfxkœ[>+>{Aec9ň67V@C b8d9 ؾwCJppXYXu,3`,͆$!xK Lo̚4v9nFZRZTin=/(nƪ;b>_+ s32h?O5'\xnV.{}mPIx՞ 暢iwL|(H==5;Z츐Hx9"D$~)v(o$VN=5w."% GO]\Tہ\mx.|~7R,Lw1MX4+GNۨ¢00$#!1a<]4:T<am("5'-5pY!9Uu0~*.wʧS5ObRZ=MحhN鈙i9nmkDUt$Lґ8yfoZ9HxˢcOO[iBTYVe1xp,vKB֬Aqixx8m+U زO|Mnݏ^Ώ;@ )ˡS^ÖK(4G_ʰRꎧ܎5"ɲy[ BUΡ5d2u9M4Z>jY2l60PUnLєׅma NUCOx'!Qx|eo6c8%U1G_asf}A/Imq#fK[+)vZ/fb6ԆKALHD߽!F&l wcO<|LGd;Uqq3ddDFlDjD.gh`rZ-I,55ٓ>GJ=*DMCYύ.@,IyՁܞ&4UNpeUU X!Ӗ`޼ydeed>}An=>vk6fESuOtТq}[=4d.SIT *:^;Z{D94gJKKy8s P  L\nBU4tS=iSKc}_'ՖĒ׳ygn8`,F/&3t=j֮l'EE}Zd ?c޽a3X ;F@G(Df>{R,j0 _˒ui8ӻc'tyG^رxu]DmS|@O D( V@KKk]d4 px[,b'x"QKwZuq7a+&X~PQS8 l/ccGUm;n7=???aÆcףۆ ]Go85+6kkZmk-Gwf AJ Ɛ( YU I?9>/f˖-/wݺ~im}wz}ժUlذGCﶥ̶1æR3.jqĄs.v<1!1}ͥ39Bt»@/4.\_!oUxnh^l^|4pW_r63T=!_Bdy[[!ECU4F HEM¬CE,X?Lƺٽ**dewreC**`ʔ/m[j/,>! hY\0InV 6k#pA<(Y9ouzy;;n] 5k`"(,Ը`Cz衔puc84qN!ܛ hYP߆D0՞_^qo"Mg:Γ<|G {`/2w_W]rSB˿`8#©p?*?VTJg!Gftէn%Y>ėW&ڌ\s 1[??%k֘YU܄"eYE$|.^>]~%,~56݉] GU-7WOxFbfeCU5 Gd\58y1TΝ;| (**"//0ⷿm3H 5k:n1nClX#( }T ?COų'?`Xa)fkeqĻ84vk6yYجNj=q)gQqyn:]&ΝTpW7mBp5[@FU5t͊EcmMb,Ȋ"+($+(ľ[Y˱u5ol{bńBV|]nC tŶthڴiۗuiaڵ85q+Ȍ--IȒojE,]6&˛9Cce\Ք 2W 4q6iRCV՟`<g!'Ehҹ'ƎkzǼq JVPS_C (!o#2xn|~7'*w7Nz@KܬbfJ FSP7Sv=k`S7~9vl`7J3\N{Fʺޕt5`) gO,)'L>Ǐ),W(^.Oq/d+wHєl\RPB8Yca`a+X ž={={vO,+~ >)x'xĮw[o e)mrEplgS8s&~+U@V);Xv-C빼 k;pMor饗ruq]wDIRrKbVL<ύ*kj>6-7z4#77W׿z(/-vw'裏"5B)蚦SW'! 1l)ĉTWfgɓy׹뮻zuyݎf1߯yf̜=܃hgh8KǃHu^2ALX,ymذ⋒_v<+7ok׮oҥbҥv]ܹ|ׂX bv.\(~_'%JGJuS/qכYlذkصkx뭷:?7_wi֭b[nIgջvRF8|pƍ{gϞ^]Ν?N IsJ)Krؼy`/@| _U/&N<KTT88R 2%;+"G}4;vro[o˚ש"P2[ZjxGO?-@Џk-]T۱߫{ꫯ_]K^{ms^qȑ>vZPOi7 nZ`AcX~\o„ bرcO>d۵kWmz]UW]%lc ϊe˖\ݻ7|cixg$"E1}M:pرcbƍu⦛n2kw &ߚnqXst|b…>ƍg0EW^yex fn:~~Vb֭~y%fona [-[Ƨ>)~6FVRXa>>F%2ƌ>شi%Knڴ+VP (s[{V^+} 7‘=Ù3g={6+W4n/9##2*6+8.1w܎5Ljsm֡3U:zxN ~o+ׯ_/cΝ;EqWyySӮX~w;foJm֭[s= [Yf1 Wկ~Œ%KӟjEu,K,Ή'ػw/_ xNy!β,s&҂?^NIDYidJܞ s,5vVO,\ӧSZZ(|5+,|nrrܿ󓟬k>̪1hy%ح<-x̞=p8̞= ЀR`Aq1{;Gذa/KNFKOͯ~+y֭[ǝw߀`^?7~,@~dY/ a&dz())Ip`@ /Cmm+v[jࡇ^MXy=b z), =5Tb8l9XtSJ/f- 7`Ee/)+kdٲI/=7"Ex|ح9 IF<]mI*+RV޹;g?KȵEUIHuL:56K{V΍sNxsXr|[yވG:Xx|D۴iݖm=>'hisquzxN_SRNW_DEE?яRӻiiFW5^#gqênŽ}y3TƨI6߿yrOZΧwZY.5,{>Ey#9^u|yS;=gJ-1v+vxx\`mx(aϞ3TUx1,ݎ# v:~ވgLKmus9ot B;mz<6Ⴄ}@jhNϗtMɤSMͳj*JJJm'x!񔕕QVVn32!2$fa1xjZzOULOS =o|_4y.3A}ctL42|~ߧۤ 9Ҝ9snC&uN0<} d7d7d7d7d7d7d7d7d7d7d7d7d7d7d7d7% ̲_iW܍a >ڼ-yq{[2PUEVQEV$)#70!H2`c #zx#)6B.6ŁMw""7ܗhM*a#a1D8"p, STBD乹BG<" AB@ 0CdK-! ,{[ɲ,(",ܞ&BF`lXt;| /< M!)?S,ai_EDuVDXcxz7*/1kW nǢu6MitՂP+] nE5!?PPO0  󷙏p`()He("#l"{iiˆ|AOM˪;psqrq:[T jE׬N0"g $IBUtT!*hA?]j%lHFNUxaޔ+Q`8&FŤ*:N{.Y<\S h( EEυk0&&8f>pTe.a$|-á^}R:r$E,r`tfЁ }X36;# IDATudI}I.hv|6__~wA#-xD#I29CM?SayX-BN|fQsb$|OW{^VTEEdat^= YVNAD!$Ǻ #8(pd).ɬ[qOsRlg椟Ijxh$|U9Ȳ,+G6ۜػH͘)Vv+3:Mё%EmJZesv R$7 n4͂YQOCoŚN~WW!oF<砩x4}uMg?Hgu|2^]pѨ٨Ҳ!`"7d UձZ8}R 邯yΟd7 ,eNn$, Mdv|o# p\|PFzIENDB`move=1000;blend=1000;3NZ2?I AI  UUUUUUWUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU ,?ꪪ(0  |ee A/jj j T*֠AABZA/ET? AAj ATG TCZ!_jZZ! P֠#j!@kVD?ZZ֠֡PZ?֨PZkTC//P#Z// jP_j PjZZ/֢֠//P_j !֨ZCj j ZDPD?ZAABIHI DD""DI$D$$DHBBH"$H""I$H!$"DBD"DI"D$ $H $!!$H$@$$BIDHBBH"$H""I$H!$"DBD"DI"D$ $I$H$BD"DI"D$ $H$$"DH" DDH $BH HBBH"$H""I$H!$"$HBBH"$H""I$H!$$"H $!!$H$@$$BID$@ DDI!$I"H#2,Wf#?ꪪ&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??+F-A]Q@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12PPNG  IHDRc IDATxwx"z,˶dK\nc\16馷BH $BH 8^L16Ƹ7YŒjW|V$ސ[\3svfsA5ض`q!-%|GTS׼m<x_A虨$-u!#P_K 'neO_oTtzDH?dOyX];6c#ӑ23v/tIP619Y8\ubkgXf<^q~3&K& 9$De#w}v<=ۈ D wb@05r &fV-03c©wgQ:Kl_N!8A3@1;N֧! 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"D"D@$"H$DH"$$$"DH" DDH $BH HBBH"$H""I$H!$"D27W Wf#'IIA?gOUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??A1"KQ@?ѱ?ѱ?ѱ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13S8PNG  IHDRc IDATxyeާ{5g& Y'BBlHEŋl^k\U (*WAE@}dݙ3=hS]O?9s$@0¨(h:Yeح.xd$U$I%!BхFE̙i#m)U)-D=曇NytSLGBD r$i*ڤ = Ll6Y>Ŷ 4^.tUt]%E3HH=H{Jaq:2ۜٻko~/\;F;аYK%i yZ;Z9?{u9'^Cs{ -ȲdAU#ɩDyw4=ehs7 Õ; l0ܾf,&;aX))@0o!'@3,[G<MmX6,&+yS/=z~ qKIK%pzh{హX6\[[Q_?<L& lP^47fu l稒NȤX,~)[v5+H'sz(Yzilᴧa9v,fǁ7ܞ7ІF#HfQJmlxnw^lE$$X)gbK 5 {Gbb\ +J+s[;H㰹Hwfz ;eESURRR5#Ar2MSBZ$I t]gU̘m^ry/05)L-nKnsJCVz!mǣ{`88a( I*64%c1N/hP{<MVT5.$qK>~iDg\F+PϮo*S ͅ,IHB3I"ҝtx+I͈wO6k V7eG|*aŘ-Ju^("Ş/g[<`A"-J87BOXd#FnMMw }(!4$Id>LVz!힆\0~vO ͅӞڭg B?n1tI,I8  L+N9yhilxm~AMռSm 0D0B$I!7#"< ڭ[oEF+ɢ0)f4M e)-ıDA,fQ5RyTqGI1&_:FT 'oy^ӑN3=B I\~ RS\qC+(-D~V?L=[*Kf]鈈'ظحNZ:wFOL!c[uh'8-4O!sAMZUX+Ɍ`Bټ:kwy*bF/uH4 U#'͈3:7vO#>./z)c'?T`ďdNwzCqրĻ I:9 bL ]%ՠ3<[Qȑ&opNP$"umlx? g $IB !I'esʒ.4Љa,w}tpd::s)ΟѺ]d఺0#=Tq%3c&Iƫ1߃td L+HlfR]i:qČ;YJ+18D0("ݕ?7 }@BFI$ B 4C%L(˾g3ڎ^ˑ,Fm*IH2R"dؤ*@wEK{-%7ധjQT-³ofT ?@\ iOiEǶ~ H'1[4T]Eբ-G.\|=Q5Ŀ6iČ>]PQT˙I4&OɮwckَI1IBo0wǛo,&.lnsa6Y%odO,s3u MMWRp$3x&5̆Orŧ !tt![RP4,A3H4/ЁI1sf)%/!!G/$8I]̛z!(&f#Ȉ =gь0r1wcP۰9$d*yYhEjU5Gab7R(̩$3} C51cاD •/AjJ1 Ssb4tL8h숄d$͙M7ۂȲَлOjQ?#`KYy>*ƗvWVh֥W;1)fƗfXdlt~8j+lGRS Bsf]Pݰ!tk|es Ee+oAH,!zK'%SQ\,oQCZUoH ]tƜS}{hj! 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4 Gr$JnIJ3''MÇx79& .|дfnZ:ҪMhj4yij!B'`0&#聝;wR[IanTRnnf>Ɋ3--CW= vZ+V)DZSݰ6q!:`K<$I`yhus1C={SA~vXP^0$S|I||sRظ|%k0H8sBOc`vZk9tE/b&=xmʹ{A -*sk?&MJMWc9Qzp$^ 7;/,Xlc1N~0e0 ~^jLf&sC=9Ypa{"Kп es(OvzO!9ʼnō+EANNG <҉@9cٞ{c\{-|a?B%5_J<8,v`x 'p7v9rJƏϊ+2Y$q=y%Pdmx;cr*'RH=*g3W/^K8^;Ng".Gf\RP_/f͚%7^\tE^9Ţ"ig?KJ;wqM7z+IJ_kVHDqQ$r2ĈM8px;t-`$k":{lZ~#2]=rН} @p᫯äI8'?H"كe%eb5yqc2'aKM6j[DH1NYW~k,=EB--[enFBǎKj$Lʋ/vcX ףٷo_&p6OwDq!t`⛶M&UNyߖ /2{0vKV%b"^z`4iu8da)"PrPGO</2wq</Wwoh FxHǤI#Sں7n ] )KX0cΔ׭Xʙ3Yk?=,W@OD0L<Ȳ.[͓O8?k,V^wݑ'a\l*]7S©HdhVBl$ I2vh_O,ܹDYY 3 &uVӓ( $(t2]d哝|:!jh~-ɖ;o=m]p}> rCذ!Kzגl(&kk%?gb2jRX?6ÖlugxWcNXs*VX>2uhRFZă_"IR_ނSV0-?wwu碼{;VyXj_|1]{) k} g̘mïv,)Ȳ$;YL,KFZ>znx0&$"םRS'sF^I2Fu(9… y+;rrc"Zfs/I%IrlgL7{Z6/~ Ey0l?Yl3ȊD0Go}Puzi]&Õ,]Q554v›%E@W'u+?{$9tEQ,Yݻҷ`8ZD'4vN{:vsX"WIFCD/^w uy>bzCHt2qhz6}>b'D}+YR`zs B-8P #jRCUؐGFjO}sXr{ B^A:5ynTjѴh‰LvA]74 /'x*' WEsr k׮wʐ5&"*%d$6 ݾVZnC(Ii=XT(ScuXҥ,.\ȼyXr%`RO(vZ֮]ۥe˖qUW1}t>PzdEQXLV&+&#Ԕ, Hs +fMI1NM¨MTh?LJN8N'>|WgXzu|3F<˃>Ȏ;Xr%]tn]|;Q5ܩdD}x`2nM99@0%J졈@P{ 8׿u֭3bk~߲~z~5W:ߔs՟}DUCfxܴv-8aKm HIs~W2bsA~V)oo^XYR7.ߒ#qrs&LH8~;Ws+csasLI##= 5"aR,8lNRǰza3t59{bIhU '&iZp 'U.c<'q0VF~/o"qZiԳtn4+D҉FunMEyD0?駟bKok=-xpxB05]ή'R2ec/k%%Ӟ䑘T>Ձ|tpǟaTUw׿u _y1}y'y!PdE \ӑ$cg2YlX6,&XR@O(BQ,dIR@voQUMkX tiۑgbHG-yGZYs(pp'O\ y>yqG8yAwB >YHX`ڪ+R: ؚ۝)F;̟ui9)c}*]h`M״1S(@gg!Ԡ y.ZrBфf<Bhh1rMD< yTnKEעde"boo?C3$@I1I~m3ĈSVΛ[D^KT$rd*yYt4M1 F k~)uȀ*}V?b[4==~%3 6xR7tM;O:Q|@_̛r!Bnʁc[@zFlC5L?wC}\Eb^N9hi?NSkE5Zzsvo<4F(Au]N]sICXjBM^T] ׯ\ݯ3ju9i1: ˒`!̶4ZO=S!&ń1y-4MewyIih=I9 !:ɢ}» Ƞ('6}M~rv. $w@Յ0cKģ<i 4$NIENDB`move=1000;blend=1000;3NZ2?I AI  ꪿U_UUUUUꪪ , UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT(/ |ee l/n_ml/v- ۶n_cnݰal/vavn_vŲŲ'lňegml-[-lȋel[ݰ avn'vرln۶dݰ avl[dn#mvݻl۶avvm۶l/vűl/v۶vmvű ݰݰavlvl/ vرlݱlna۶vݶOb?vvݻl۶a$""$Q %$DRDRDJ)!)A$$I)$""R(B$""$Q %$DRDR)!)A$$I)$""R%  QDH$EIH )QDBBDJ(IH)")E"(D QDH$EIH (PPQ A$(H@QB$""$Q %$DRDRDBBDJ(IH)")E$(B$""$Q %$DRDR)!)A$$I)$""R(28W WfW# ?&vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???؈$??WF`94`S@?%K?%K?%K??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14*&PNG  IHDRc IDATxy\u[SWORԚZHH@! ASb`C'k=`9^32`2oؼY؄3ABcK=w\u5PU-џUW=U=>[Um+@“?e/:,[PXr$?7}JHE(Є@/꧹%} 'ϿOI\vYŏXLc; ;?A$%"TE}J C1)<`Z:y{">`s-8^uLhbiilcpݪ@@U}Ut86:RzDZHofQ ǵ'ʾXχD}$Qt3ÅgCWW%z)]A`;&B(y SsF@$)]ki㽘f&].RJ@~Ez]SE<54bC^RJv_y"؎}9k##ǰ?z,& {g0e>o/R;y]MN*$D/=amwWzO"|ZuMmBa͕'{;ފ1#IFO00|B'gRBkR_&#Va (+[Vu'ONmXjջx7|iv5hbA_fd:rzDUTgrYPW? lc;fE|R޵]ңF𕃛@{rkF'і:,AQTUv ,KJpMyCVljCֆ KUXÇFX/F\s<\į Å#Y!  (@ֲ(nhĶM><ʄ M{d%ضgwpg@(ЈjkJ'Ug\/lM,ۨi[,[_ S7sڣn=OShB(8E<5QFMNzO)lǨҽpN7oZ"MY4HAb)=VkFM|_vŲ *ݹ 2 ?qN7S$,ۤJNxrP۱I\if`8+gyxR L+a*y6{-P BLK'$m4tMKFjnz)LKG4Tno.7T;zLc!V,Y7JpXdMlz!E(}!LKDz \)%ץ- MaVtx8z`Xi,@J3mVU~4֓SUyp @QRHDV3dRJCշsLk.$k@(ބŷ`GOZj&GZ/,\r{p;/w*FM "KHMO~Q vAU'dιUēhMh4KnCU4l5z4-@ҰiQP^iOQC-%'I9xlto[1\c3&#筺qm\AQ54E lh!L8V'Yp5PkOMzEBE%UMqd 4ېH 3M*ハ_-OH8l!L8Bؙ)z›:}T&F$Oz9`xrn)ץiϣCѨķ>z+f 6QUUΟ=E-HLK'Tъ<}8=: %WoVm⯲Y:ky+? {pg/"1=Aa9`?WM_+.iNQ4UEC}!T:e² lBS[GM E(3U⣏>*y3+D *T2ЍñP/,.kG>Na?RbZƈjwDZXdk¿nЍLPW陽gus4B l4?7M+3Ϫa*X,EEQ6I@g'by#9%Ct{Rqmol[Ig[TeDZ'$Nn~KJW^yH$2aXS zѶD6f%*AOv,La8rv$b=tjz.ױ'!kfuwnRqr(&PnSƶٻw2%oBߏ~0* Y/3DZlĴt@K׳dѓsCNr`;cbFgÚmĒr6T$Rʺƶk_˚KȽ|hS!DE(~qyrfrL2z@3;Wd:XYQ}T}}Y+iYd=&(,\0S;Ḷ{SM| ǵpe%y2 {/޲qoLp}|}k.b~ 3Mӿ%c2(PDśHɘIR8V6g\T Wza,*\@"o9~M=*P ֥aț"7[nog^|"g=BxұJ]VS45'o j i>~n4~ =ǜ箼DŲ-$s6 DzGvK[V/ٳW_~^}" w{=lV3D|0dehlhEU|}ATUwpi@]d݃RX'5q7"LTb~'HZA m 3rT^qуB(8:1FȕNVr4-] xzߒE2Fp븓ߙ"aeT-q޾/, i؊쭓L1r:*LjI"]񕯔g@zvqG>-_-KfaʋkRO&'pضO EUՊ!WȨMq$u_:Pݻ,W8EYsQ hqm*{A"A͏\NH3y[?/y¿sX0v|Xχ5fOF2 $ +߼h!fݺ]xW\F>o֧v,,3Ϳ0,h]̪%%tvoϷ,ʠ 2U=O(ЈX^od#* o}7;7  a|j/4?>Տe2+D۹s'<>2n#l1Ԋq̪'g(Leby_xR'xy嗹җ/5fbOj 47 ~|>?{ә$$c׼h\ttt@r~N(ʥk+0fyrld&JSC6muv&W^Wƍwî][d2ܹ3M!DJxPPP6P$KW}~_Ks{ؘH2(U Nk{D7ciܫLK'O'>W_ /oڳg{6v#\PzgH)QD|F'< # T8>>-8&,VϠ o1ڸy ?ʺ 7VYC8Bߐ ~]αcbe2m46# J.ͳ_z(#0 3 ~_W]Z>S&B*vxx>MGOj*n},@S}kųs-#;Ppxᇹ{y衇8ii4cv{kz5k/rUWޓWロ;3l۶=y~?? ]T uPf軒CH!(TMO<_cÆ rǎrcu!;VEm+;rQrq{j׵^;Me\q\y\ryΙJ@n۶M?̗}Go!{9y֭[ݻܮ|ѶRvvw5'ǤvR8n}&e_~9/<2JXp!w뵮a?}֓'V3nc?MwuB}q7̈́JͲM~ o~tvvOsϕ+U`,B/'_+*!HUIMK / /j_)o|s]w V% Vnd֯UܦnrmKKΓ笼DnkZʎrYuyJXUk:x&,LGuEc}{e](Ȩ#j vTlD/XUbX'Kxw~܏y?`߾}tuuyl5N@ /Oy.?O~ /[nD:66(*|1ߕU3^zi^>qz#~~>{*AySO=1iMO_e8xꅲևLJM6qg˸JW4G#1xIt=M0Pmz{{+뮻l(du֔ܥI);j҆>_d2uMJYy)iGXrv1ǵ5jFH!Mn΋//$gp>>!BJכ<ϑgrt|_I%QgGQ/d6koE"cS|ñ1ʌW% FO2=P-[~p4˸|:|okoꎵkuSJ+]שսfDo;b,_|n ۿZ9g4ytQ]}G6h&2444x)"oQ:-,}N鈋#|l39~g*9 IDATaǩAsv-mԉX;6},_25X0P(ё'_*NZ0-U!:#G8zth4yfm<3^TqEA;ϟ_F"~:qih¦2V}Q4яf{{Nu2 %F MZڸWkZes(KxQ4TEU[P!q㛇{>7?17o /vm5T/X'ܲ2RrުȤ55EdN!Tݻ B|߯v-fyK1ӘF\2.Ҫs"_y䑺{N%0UC ~m8tPUYh{/?OǍ͝wIɢ jfMM VC#bT /vF|ijjb~!!NV|6= Ay?9'S^-'{/OU)MJy HΦ(0)0BN)]vrw8 nӡ)SV1)5yP131G9T9̡b̑gcmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???*"$??@1nJ@N@? -? -? -??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15j%PNG  IHDRc IDATxw|\ՙN̨˖q`bp܈)FلMZ7dn eI l &X`0z܋,cY})~y3W3HFls93is#92@8qɉ'Gē#crɑ19ȘxrdLN<92&'Oɉ'Gē#crɑ19ȘxrdLN<92&'Oɉ'Gē#crɑ19ȘxrdLN<92&'Oɉ'Gē#crɑ19ȘxrdLN<92&' 9-"$! vB0|2E!8ح|Ł.RN<' CKNh4S((`omʔkzhB":\Z!/yC'r "mSk Bbm$Ͽ-fh$cS]1 )I ۟Oy?PUlVs@53δҖ GdyET$#e#(-<ŎyXhl E P@ HddYFdB>]P ?w,֭O^b,%k@E! 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PU 搳l!gMHoJ[I8|eo+ꛫZ2'#4dɀ`sj#9Z><Z=uzӲt?f5?-aUZm˝1'!ӔFvB h:rȗTŬ\l!,˞Nи=x@?߶cz@8-AQ:&%pNϔHzȳ)%IDATg2~ x?d%?@|ph->r{ZO&8oYɿ;"`sϺ*Z<*O|8?U*.?VW5[IHq/В&[/lվ߾|5zB-tꍤε # )ky˒!kϪpཌྷ::n݇ wORY(U``O 2,QI%Y<]) f~p$H8`ԥIN* &m',>$uдU*6P: y[IN\@%{9c2Ztlԑ_{H(™}N-ֳe;zs&WPmfMD??hd4_*T%uG/"!% $͘)![LՂ9=ew+b^m9IShQ̥8qgl.% "i@E! %-C>)ēo/NZӅԾpmdƍ}݇4]>5|eLQa|‹(=CRd )+!s{BJ IxVv_B4(uib=S\0D_/R|şcX6I_'pw4{O Ԧ۟$5`Y8(jFY.9qS(E<Ȓw&է[_U:r=!CQXA$"}D[Yъ% g7WD'vX9UMǜo٦7]M',ʒOW(JP$]AqEmJ hsaY /Em_4w Gaٴm펤*.9!ЏL<=ģ}vj ӄnв}h+>$7㺦ꩢy%n85B^$ gpЂ!v^_[BlAmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??@7A@1HK@?`a?`a?`a??@@@x@x@ ???333333?333333???#~j????333333? 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$MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??1zCO@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17H7PNG  IHDRc IDATxwTwleA:,,wDQ% 5 h盯ĨQ>ƘDآ]P,"݅e{^oq̶Yo{=~9)rF0o.?IA>` fW`hO^v!oz ) <>{oߧ>TUUQUx$%J+wPp`+ (>̼!|Ezr< [|{J7p0w#zx.!oXhPڹΐ'PQ A$)ȐUW^v!92ԳD8k*n" Ѓ?,}fO\ <\fTU!(ea't=@NVo̹gdܺwTח|twzL33 n+_8UUN6h!Ә:fEpV8v> $/Q^p=0laC坞Fm0<ꆒ G3Pk0&rtyS/Ǩv:~GmZrzc5g݇9rz{yF{t b$Q׉kA/zYD~N?`–Olbhv6#IAt:=#Oz*gVzcؘ2j!ʾ 7a>pG̜\ µNOρ ( @Y!A!,!zLedYn ˹V ~G7St^4ګxNDQyV%I.@QG0'" "IHRP(?pa1gk+ ?/SF/`8=Mجy(XL6T&Tъ՜`e.YN#:s;hhlsɓ99P]ngEIIv>;V&9,um.ruM8MfNp9P Y5dFΐ' V/mLYOxN~gvWn]PU߉BRJ>^Ĕa!(*3bДkΐ' ٵ7ßp76s?$ I0傹7HuMGqPQ5[(Ȩ*(°Y0j̜'_? /Ī=5<ǎ)dgj&ڋicuG400MuvW=9}s.ѭ(ڞ]YUiq1u3'G4P==݇?^MΘpNUU<>!)snkbw58oƕ^UQcJ]gȓ/Ju:K(˱]veln(sxP I*jQt[[ۉ*(1a+@HUyrS,fԐn [WvV>l1rʪve]ތ Aojl2cE|%rmRu356s~Τen₹7g|L}K%MZLFKxU} nK&F *;DMfnz D# g$Og1|DrlEʷI~FŸs8\-cmU_0:XŦeCc2fQ4p"Gl!tv<M-Uxu9bw9}A8%OZI ϡ͸4ګiW:X4뺌ƖjiXa\fA7P3&D^V@Y++ u xzG&<^;!)DZCHr&G .OST4R| I rU Af g^jQn.YQT9uţ,{9[3#Uo M"bw4d l;(5 GܶQKpy횋$2|'B~E1QVU,fI꺄hvօw]|/lD^]_BH Do> Gm,jb +2w#ErjWC8ҨR=oOk,4tgxiqa1ȱb1jL|D5Έh؎LuѢ5D9:z}Gct<0ڊJQdY ia=ϴ1N7򈈂;ݜزQU^gaMş˜a)ܞh FΙO~) ΄ׂ=&GuaIr@ˠ~SyDA T_⬋:Yٜ;met)mǠ7a1(̬ivԄ5`4X8{T7楢mb1GAʛS\k:fQiDMg9Q`ba2X1"B cʨhl9Ւ^glʢh$ʎҶ%]KB q Ba&8&L=HUUq\Imv2݇Ɩ*$Yd*2JXDʷ0j@&#d#=e%Ϩ35bfMXʀ‘Tn O6EQ2gHe#$YY)2/>>eerj7M_-a04hW1c)8bV|AmY;Ne s w"IA psLJfguxbn/}[Xvm *J.[o ]T8*R@NYcwՓՋ,s.ٶ^ h^@DV2kxdb5pδ|Er 1{N65Cg2zL[wGΧf_\ r )W[a NmڼQgǖiW$8\jKx}3x}<>G5ɿKϿ io!lF!T՗p^km&hwӌ?a9x|NM,ꏝi*4ڏڹh Sw^ǔʣRGEA(7W2{Vj<;Nfg-Y\e]oQh%˜ٔŠݏՔ͈S3QU [Fj:mQ!ڢA!/.;%oVp7 z݇?f.O3zq6(yl$gUVA"RG s%rW]5CmV8=PXFyS.jr]/wUOy><^9\f!/Kf K~*h-fRcۯ|c; /GƏǐ!p:}rǷmNa+gs6VsVs.U @fg-fS `50z,WldBMe.!]E'9>}| I$" ~OUU v{Ǥ bE'꣊=!i'D?p? !Hlz=Ս+ޯN=\)'-f: =q)_z}i0G{ +%@yзYر#0{JA";j]I,tz3FьhbbB7 `Qc40,3r>oYc ,Mj,,MYzd+*E잮@>D.`˾{ lnAUi 'pdn87&Ci(aT5F+tc$?bMMI 4Z &3&,e˾9¿o1 ]b׏,[vg l@a1SY{~Q|mD`w3|D55__[e7ӷD2bj0ؘ0?UUm>R(NU;I}|Yoa{F /ٰ?(*L9Dm# aD&7nfҦӚ<;}JMcw#Y;N/wSb[ Dh?j&GM~A ۩aךx6"m=y@Jh?W>p'ĉAcÙ rRjrGtb/nDxSel^. 1xfC={W7t7LgOY0q4oj2DՃQ f,0Ss6D#i OCC#UUvSYr<-@UC)w#/y*1GUeF ;2zc{qs"ZfM8&0ǎ٩sqF*ģQM]swY|g-@:Dm\v4ՠ)>nSQ*J+W MMX||P;CÜ@v"•K~;G@ԤІ@7_PB9Iy ):esky3 }[}_9A*S,f0ywyA&$Fo}w@Q Ժ_`\Ѽ26zeڋǨ5\w'uIJr4qp]8HHefG5!)Г\Sq` m$P"$q""ku.Ν/*lkI;߹ -BMO .$#L7la4(*Ҏ| sͼBTJC_6S'M1 F!W U$%!P&,}I2 H=v /غJKcK+wi=曹;xSyOedXC@3 }ej͟Җ*BH KAF P'ϲeXj}Q?Ɍ+㩧'矏я~D36%?~SvB=%]@,q"i"g-DCu:哞<7pK.e-ҥK/ểD"m۶zgy\.}QMZ[[ރD ޲ .xt=VH;B Y IA$9Ѭ&믿Ί+Xf J<檮CtIjlٲM?x2~0ק؏_T>.G'w^UUuj@%$t'-y^u ŋYJnA qXDBAһb"e;2xgU-Wl85-:ImsRnL&fΜ1{Sٓ/^ljCst *kc! 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QUيՔӡH]Zʥ' JySTUeε4Ӑ<`ȇb`0`/i߫h>.>;sk I "ɚ(vl4yn[zܬV_7.e;{0{Jףhu--476(LnnA}g o@ PUwC7*>;@Vdhנ*RL@tB(DƔUUټ}DU:Me)mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??MZF 1Q$rZ@?\?\?\??@@@x@x@ ???333333?333333???#~j????333333? 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Z5hi`cHBY6>5H{O 0vƠPV5 ˗1` x[:; qzىd StI@[˥E٘ 3=>:Z]iɄ9=Lx[a Ki=t}#3͸126m[ǘѥD!2zfm7q+\:H9mnWRzޥ²[ęfS] l7ZjQ(@{+./ʫv䯶,ކ™9[M2/HJ,q!S zSs^FVmCsG#AdEh5c[c4d΀(L9vI3rިX0:)^ 3cF^N!J!PC2i!dbX(\9xRÞ1i9ì7H}9S#{,iyUlWKMC *Q@P\0~.ADp܁:9egM:am} 5oHA#6߳ź,RyXÄ9̞|g]ʎU+2rHfΔ|5م79YB{:-%I`< ǜodhahvaz|t|Ţue KouOy"[Ls&@#jZm W,'-7kk ۡ@b<'!|r5В3֒5,^[Fբq^g͎8"}_SV2SX5D&_5-uqu"}?Єp$M!( Q0tT!ǩ9zfPыf]l;Qls9N8G;QOIxr?NʫvVO(Ɲ(@+l_!s-E"NzZ}ao%$.9ju"/@8Vj4'ԭ8f=jQ6#qO3$3Ny S`%@*|m \"Oxw}x#@: θӗ&cF.~{DZ[h ngN<ٓ`#e dm=]Eٺo}'̳Ai[0bx0YXF1C*쯡= w3xu$@ӱ;N0a?&vs &Q=$z3ubdEACkĥq)\9ÙP2s_HuuQNFǓ6_tnv!CHd;6֦H+/mfg1zv4C gv-+xK](='?=ޅtΕD󆡣Qg+QCLe8YϨI–n3gejܮ4tF~92 ׎8pl3Jq;M(U-+#u=kdۏi':[x!`☹} c I$iـ l:{Ε_Ù`8 m7jQ Sk^z<9Y I4tñȆT$YFU\.lfLØ3hOr7 ZZkIOJg=SJ#?_[IpwobƄl=:Uf d-ۚ ttI"A'FӈMbjNޗ{vfЍ#5scXo}[4"8 G۩j8@]S%G2r(F ǰ#eB0MF_%.k{gըRÎ<vx)Ǯhg쬁d$&IT\XF8r:[鷡?pתF qulBB|mFvPY1sME^d>`o[=9YšBO]&)ͥ&XD>~v褱NBiC>d ssGb$hVG1}*RQimibrMMî a7+|TT&;3ǪJ`*Kq Rida5L3}G?BP\8aCG2l>S=>S-"*=Dm.!YAg 3_4T.o@^NO!x̚x;&54wh9޶z)J#+3sS. oE_"K䍢 oh%G4y|+d֤s{nϏja=Yí w,]u\$ /$-BCs5i,RIx2R<,2simoܡv'rҙ1։$sYLh#:5!_v@@bM^nv4=JXmPGwt9,IN!9/AɈII? әtttMWihWeye1މ\}5K?\x{!Z0ih@lXLb^p :w5[SF}qٻ>&aq5;U55HC1yk S.@#mYe(@(Dm5ň+=l/Hq8B4yyucȓt5- *A/˱hL] ȇ+hעjQ>{Dk!ǐ"j;R)Ɉp<1#$Uvb4t^Ͼe{Ċٵmv,ѩSa-UnBH}Dk{3:‘v%@2L4Ofz_8Bчsͪy T,?ğ'cҘ3{Ipb [,`,'Kθ SXleSWR7o[3lwhi%uZgvahSMA(Ew9U6Ry11pCULapI9OU,ƲJIրGD0޶z!?WsDALa䥷=m}A/~x!J<zg۳ViXٗLJ6+R.QpL@m:7 [@jM7a?5DT a fJbNh.9+}cW?Z/qqc m60gU>N&֞n#X%(OQ'kG#ܾ6h$qɷ|At-J&GaY+>ꆃYqK3yl[v5PnQíJ( i==hr]Xy!fTk\G G蘞8S--4mD;(˒̌tBp5%9kY3^|[w/5{:'AXYV`Hf>i4T;|7@ӣde`O8ˉSb՗r'`&ƅ/3wN#hi`hے!F(EJ;1[,vWټՄƝL0Id0u"UnM,L^qΎp$@(܊JF<eP^MlAx[Y3mBQ-;_d26S|ԶZwpʲ#H'/t΃o||gnSI̟~;8b!P@#z5m\r}$Pp<]껿zUFfFiY.̑:`@1Z|+ Hx;Flai'}Un1TV2;Q5DM]حw~daYAnM*|U4dD82Yylnz AB"#}a?.[%z1(+L0:% vqضA3UC> 1()XsQ5w_bRkF;B}ЙSWFU~JU]9;0jV@?Ј:0̡骳tN=4kD |6N2l!QĈd;mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@??? $??`XKCSDw\@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 19E6PNG  IHDRc IDATxw\eݸ3}{dKʦn* )z BE) Q (|E MB'6neNi83gg25u53yΙ3yʧ Ȳ,3T*J3o2vŠ7!ˀi勑dd Yy1s2fN< 1?!d⸹N`,qa+oyaV,qxۢ^/+D3fpA@! 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CB{^s`7^+ddf &bL@/᷿GpazCJR&tTNZ^kӍeV#x$RBqY<®?ݮ߾p RxLP OI /^m{V2}#yih3RߺۨoMk<.BB?~y8)q7GMbw<=s&1 JY`ܒQ'-.{P^uكaM1{5= tCEKn/=asM7dΔy)sﲢJOQ^ \^[|bA]-"#{mɐ,&ebX@yaodLA& y{ SOii79g:6t￿7ܭ&α? cUb2&#I>I4z|Urn~_{ݺuY&K>Qq G6fj`>V ά6Kū <“xG}[ӟ[Yiaڄ G_IxeL*scÉ/w@Nꨯ端b̹ +uٕI : jt:#ciĉ$&dv#pO[o=@`ga4$R?sV Ov!eE3vyA+ yS/AꫯreJi9s0uT%2'hD-T;o }0>(~lj h3\y~%w;jcWׯX+ϛv13M)[(/GxoҥC=z$yʕ'x= e;;ɉ_\Hr0qC6sgyfo}?6{WTbОZq%z 5P;^xAK>(BԶVТ"2h9ܻܰ d]Ao0ފ+=W_}5tYD $|6mܣi>cTUŎX 5'JLhԣIKbQelԳhu&oV}G|4*QybsAc#> . ݻgee!2IN'b.vAy|k/iI4yGVS`}F:|\uU|GyJJJ=&°'Zi܍-W{f\|~/ͻs)+D3a4F]2S]oݺuK1t:GjFSA[vG[1h3Hh10dHmtGIw w]}!y"6aЛpVP^T g嚿u: z]樐&'c,)ci 4}CBqT뮻?ͦFfCQ稂nlojZmW |150"`2$Lj^1̏v<Ϗ*\T(}#)eEjfo_Kڭ W qSE4iII%) Oڝ #o]|?I4,I H ~$}}YmF#|JX쭼Qz ύ( =GyF\x ˑ {jpvQd ɣψ OP 8]H(džkl;@I۾=QujtuFL$D:|qw,x}=GuQψf(/I~Vc&`LF3Y ou: |>Lr2HKFh!3<_,KJ9Q)WF~u6KyLZ#Ed`LA+u%9!{p{z|.\=xzH,K1WN<1db'mvXS(#VeV!o#PVT\PJʂ.2q<,6r3DZŸ9xLSm0uPVTIׅ'TX0h2T¡9KO'+BҒqzF6oh;mMj}#|Xdn׏J}G͡e++(#LjoGOta3*< Qe، (fTxF63ʰQͨ2l~}d/i;} 료FYȴIs,ǿD_(Q9Se)cͣ2J/Q-mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue acy g 196cc1(+<= 1vbinding site for residue bu1 g 197cc2 y1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1ubinding site for residue cl h 196cc4 p1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue acy i 196cc7:N1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESSS1met->mse selenomethionine MOD_RESWW1ubinding site for residue cl j 196cc8&&1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES 1 met->mse selenomethionine MOD_RESUU1 met->mse selenomethionine MOD_RESYY1 vbinding site for residue bu1 k 196dc1881 vbinding site for residue acy k 197dc2+/1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 ~binding site for residue gol l 196dc6(+== 1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RESRR1 met->mse selenomethionine MOD_RESVV1 3NZ2B1$f $fϔ|ee l/n_ml/v- ۶n_cnݰal/vavn_v۶ݶ,Gn#n۷mml/vn_ݰ۶ݶ,Gn#۰6vl/v(RB(R(IEI RIE$E (JDBBDJ(IH)")E" ((RB(R(IEI RIE$E (BBDJ(IH)")E"PIH %A$II$QEJ)!)A$$I)$""R(%],p f$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU*U$II$I$hI$$T+U+T*+TJPKJ-R-R-UJJDI5UI$I$MI$IjVVjUVjZZZjX! $MUDI$I$$I$T+U+T*+TJPKJjjjUUh1$MUDII$I4I$I&ZZZVZVZDFZVjjjUUj$j$I$I$$I$-RԭTRԫTR+-B"#U-+TKTKTU**C2vbinding site for residue acy a 197ac3 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1vbinding site for residue gol b 196ac5q}1ubinding site for residue cl b 197ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESXX1ubinding site for residue cl c 196ac91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol e 196bc5(+=> 1ubinding site for residue cl e 193bc6MM1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV1~binding site for residue gol f 197bc9(+<= 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESRR1met->mse selenomethionine MOD_RESVV13ECT\= RZjOZ03?ubinding site for residue ca a 193ac11ubinding site for residue ca a 194ac21met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RESOO1?333333?333333?333333???????@???$??@5C D]@? h? h? h??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 20QPNG  IHDRc IDATx̽wxٮ{Umƅޫ !KHB I!! 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