#}3.6-1h/data/swissprot/ 3O7M.pdbdupa 2GEB.pdb#[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.98 Angstrom Resolution Crystal Structure Of A Hypoxanthine-Guanine Phosphoribosyltransferase (Hpt-2) From Bacillus Anthracis Str. 'Ames Ancestor'[/h3] [p]A.S.Halavaty, G.Minasov, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3O7M" target="blank"]3O7M[/a] [small](deposited on 30-JUL-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  2GEB.pdb3O7M a_3O7MB1  2GEB3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iￌ JzyBJG?WO ,U7,w`ٲ㾿 pWvC݁!b۴7fݝ?WaN{=XzcxaYч WNm9d74o7oUB.<Z"kQ"ٰ66Fzp҇E; ׳w2*Z[m!|Tw29pݬGZ|:_ÍJ1e,/zҟJwR$_hk,];%dPh#thJSՖ#=B(O\Zo 4!2drr,nEz ׄvs6+^BvK?v!+C\rvA.!j /ǺnSB~N%*RZa;?u݀Rgv<ʓ1qyy\p39r`=L j JZAT铕wV2$,+? bSRͫ[XРqHLnJ29mnmÁ:@=ῃQ# ʍضWd6Z!Nljciئ K'\FF"tM gɻ}`)/;'^vxzǧWi͇|LliZ-m]>kϚw/x_~^y<:Qwhӂ:wg_h;'gTQ~ʠ!p-rQZhl2N}& D3=8<ߎ1Nhx !44S坽QbN6̝4e@:utqn\̭W9}쀶+ҼRND {E!d2FZAPPS%y0dm=_>s8.6>!~=BRDRԹ.n(S9FPS9E~!ȻC< ݃|SsΤNaֈwp=~c7=ۿc@C%=*;<|W#+OzN4LFW6yk;v͙L(60p_RGC:MH-K",(޺O*~FoS:CB]/{_AOw3I5P7%\$9B 91fūO' "}{b6wM ͇}yBbԭ[urqTN13XKW}J}yy|7?gq-WZ FH x d #J? t ~PҵkE%)¦6[t?JAx1a:B\E2;i:y/xDn LIlC}>VʓX^A=_)F=?_{p'Th8A,U.ī&#)M:d3}{|_[S9zpA@/5d_L>4nւKgO/hܬ^m@}` Pe4l=0F,6Lc<E!իWEj 1%d-p]rՆ34_M 6 F´WX ʊ&"eyϛoH2<0o#ucT7['wƐ5L45bvICs1 Mq.SXF@5E~!B( J*5!`h|3}gq8df Ձ@8 $ pIyK+**}. -diD1,=o>ym~ۣE"nTkµ}6c 3' sA|l$i HI=>-]t ,!8*۷k7SGH7 2K`Xq%'T pl6ۦM˻cx3`g|D~~xb$}ۑ^o`x/x,'»Xuc¥#gp KOu "լsl&˿~>\IQsj1.ЬNSy?Uc<;֯d86YVeOf-0HjBpUd͛ovKc ,{fmtWK%3M ‰F]ͼh&#B#4>BTV>NC]sx ;fJS3iґ߭C&q)v/hLȟ^2/F0ku0؂ҩ^$s .\GDa~.’_/џ2V1J r8D+X e~!]K@gBw ծ'ѓRY<@ t2rk'/{EyH л(+\N5!29.+sx<ҹ}:L/=xC^my6;e\Fazh_ԨլzM!ShԚA1XTDn!@ڧ Ig`.T ur:Aq&J^ؼCs+]0ȋ_1BEˬXosd4i@#fXմ22pxNR4$s[̀OFL2B@x\՝d#mmf W sA3eM4RHSS^KKj7]cK KN<# E__rnĦ%(2B+ρHsUc\I`^=5yW(,,-D$1x Osbbu Ԩ]hzܱgEm `8h~;-ؾh Y+OávS[_m'#vΪ ٲf9y! 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"FD5Z]h݆~RXAn"EQh,Bⵡ Z,d|ۥpMچZAmR)'7' Jg`$wOncٲecǫ.i0Oj;RZ]OnFX5pbԨcC)Q?cz~43s3-,7R0͍+{iWv^d@LhݶsŢtS[,^~#B\.} LU`)_%_ˊWysg[I'hG}=(_K,l 5 f ݇NfĦaaiItܼJvf* BJ@Vs'ˋWy 4Ԝs磁'uPrY7!'+y\$}iG7OlFϑ39qo233ڍx$w[Nɓ*F:dSyq)xGTk#RP*Q䒛ff]+Gwֲf8tdfeu+5b]@7Q*܈Ǔ"jx$[Nnf9<$7#\JVe'Wʑ}-+Y=ɸ,\nLr`KDє\?'D[{ܛ,@x@ڝ# j+Qծ+F?V:^ЄC( 9a˪t&+{IӼAOU#c{qy;Pddc/ZM*جy -$T(Rl i]&ڪ\s s¿cJo*x8M)[)Y Ulk<4RIDAT|<ェAO/+p}[S{@kMWzoa|cppŶK?<5[z5>IENDB`move=1000;blend=1000;3O7MB1    BA?d$H ?$d$HC ?  &BD@ 0 I2$?nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M1   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc61?333333?333333?333333???????@???ee$??7"WOM@?ڙ?ڙ?ډ??@@@x@x@ ???333333?333333???#~j????333333? 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FףP^{QQayro9b0uwZ] X[ @j$ITA&+ko !tXYSZjTkb)ڸw:|Jpu: "#9~|w5M5:]NuCǀ]{AaTWPVQUF:O6*4?Ξ57+(XOAz_!yl-/VWvv)v3vv2rsWzn3ʨn'^@(/$?|S)Mxy98ر'<<ƈ̎sw[8(~"""ֈͶ_o)ao& \]ۙ\7ihRF vQPPyt0c~R]0َ0ٵB=DTsH2 h({1Wy_ߺݺu_E^[dgwC7Ĕ5=8*$IukFF4=<̃PjZqtz6ܵΞ݃;ނCSrxRGQl4\<=GP!D){{g\]9{-**bkͅ wiCC_ƚvgX[QZ:]mN!7wvvH!|2(h,\ ZmI^ػׂq=?e68vzb~SbWw@5>2!0mkm(v>=utlOe㩪:HXXwےW66d2r;!8EW;4GZگl\轌? $7[7cO޾hhuii,a ?"0p 5!?M\:_aa,ע9_ON55-0ڥr7zC˫H}ዴ]4j,֠P8#;V'!aa9* d2g ! DzVd2Bc*5Ba _S\5[ܹBGQY /tkph/@n,qKɯHOMP90TTȐVOA<7+k"AApt66%f!PXͻ4i$9y;*6WVnƃRUrA}6nsShٵ n3]v#0DS2,+[%8\Τd@V/D.O*9ӵ?qIvbcSibj1CfzDr9xp>iS>-A[r$ BCQ![u'?3*矟\N8Hv^}v2Y~../ןGϯBLi\Iƽ$Dt8||ڰ~j"cqB&q2@^o%vrBBFQQݧ={>FEE17~S܆ky9妟:G簶6zl˝pwwApC.ȑ>DE-C+"˗MMhzPP *G~V[AǎGAWgW3>ӧ"M{)fkwfRs)KJ덺;- @3aaԩlOII[BR$ aX 6Н)uqiϱc*s+!,WŞ8yr1*U>MǡC'ًƜ9 X2~wU&*-+VfPR$&{7(xU[QX#NNI)C_W!di͚gSm[x@z4h3JpwIQyܬ2LfBaiwNocN yy[M\Ljj5a cUAj0CO%(-]Ry+(bOQVjeeDF6I:`'c:7"ryȸAUim= P|NkA -k F$z-Ƈ XxY~ee"J1|ZCr{$kk/ʌd?`g}'rˍ񺪪eGT!rpd\ٍ%dr{Fcc"I:\\^B J5L!j˟۪?lYMPԵ@f:l;M\EgN9?nju?ɟkhT۰m?+W丹cm튷wi42Q7H\]'SZzs besRwzuG\rs=]uTYinO JIyݔgrZRW<-C%% ŋ6?^qvv !zk_|A[ɬP d29TJu,OQ#[>ZIӦBlGQUe$UPUU7B*ήO^^SP`ͦXuo]m@Kmf4󨬴EP*cJR9r-.YvpzRS_4N}KH,rs joy4QD$!IjO SP0'ZȥKDG׳Ֆ5j냻qtt*UQH\\˫j'\p1Wpp<<9~<pH AAwiCKʽ5e'RYYڰmVVHR1EERvԗ gٹpu5xzZ;e //NPhh7ѴS:Z8;?.ݍnq†qV޲6'%\?v<ǿ"#s{7ަ\]<'N#<[)-@ I\.g׮> j|>rIDATKhCs% J7B+B\xG4QPS\kMg{rsK޾ NNzP8 g{BB +P(onVWCШgh4)-5߫qd<,qvwoZ팝]GiIhZm(tNNH&'~3ۛIv^~=”226`kGXYq;X[7j0\0C_Ɩ\9Gee1zgg5^Ͼ};wЩ>2==wqEYy. GAJzLx3.˗3^^?LNW޽]ur }NyyŧmJeeMթRmʪ vvjfjPbeUm 2z!G.X[GrAGH/@&bWnY_U#OmDDE-\Fs 3ٿ ꂃ\@U-<ՇHR)`KWZIw, CQ>6d idK@KI'vQwW8Z-tԖס,M!Oכ;"}FeD?GLfOiOZo [z /L@ ʃ1b0Xv/P(`4_j!yJrXu{o]o %܀0q~H\=#n@ NszJ͋lUO39"kaYG`l&3a;hCkg+2˪l[j4 U*-ឲ$[Ugޫh+AGZ*ElX$_LIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7MV    nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X  Hkyî8hudӬ@Ӯ>] ńÅ@a@*8 B 'H6ͨ>8 8_y"ėR] FqG >љ`ɔyNq }qc&}ΗIiJN.E m:@y.CPʃξ* |te`(HpHHqȞR ӌca #,RM*Ηm lF&ER(q2&D.(@PL4Lh$ qI vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc61?333333?333333?333333???????@???ϰ$=?ٶM@@ WI7@?G3?G3?G3??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfaceMxPNG  IHDRc IDATxieY;w9}_3oKUTuWZR7j-IH(BAh 4`&l! 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S,8 $)C1churL&C^z7?}l<Lseд9Wzcޡq(ċyf1W\gyyLg0Mc 2b:=b8ao&A,/#=n߾yoa<3ߟ$Y%{g__T*Ey:!rtùs ǻJ8qhDzhZHxr0Y[2'lo0^_S-,,d) jCd2.٬2}O }" {E>̓-Aۄpwt>6}bϓloo8nm>q,=m?,%&7ET* |O/χdDQĝ;?]q4x~[Q(PIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M)  b*  n 2"`cCGABЄ$ٗ:DI4uq1ki%{9s`Mְs{kZu;&Ttfu']wu(BkW;_H;qLsG\uR͗X됄u+9r܋&aBf]@'9Z*ێ93.iSl εsruλiaΐk k6Ž!9]q2ruujaC&]ta8@1T3F 1 2{q fk$cGNř]X1I9.|-EENwysL5bKֵ5FQ99T둊pYҹaJyحa k/qjA(:뮺eʻ4uaZZR){ŭcm'1|ǽ|c≬ƌi,+&l0ŠhQɶL;{4\r'9M:뎺 'Z֙3mncc12 h2J):™\tAd(2dP&\q+! 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GcDh#lqkz [$'د"Pe `}N3V4o[ g5t\t%azlSB[q g==:7ہL K Ųhl -|'P,d#5e( 'Hr FNC=D{4 d'VFd$S_ݖW}^D"`KdźG#~%uAK'r}n&;]MyfwĈ&Y+1!I>CG{=9|hɅHv&KXrn/F1=KO ̺D\ D9}jdƳ*V8{oi8ChQhfA@~C_q#O$B({Vs^e1i(wAo\0q0%fڈ9H@:2bB U⽱`!GNqJ&8ft<x9Rhђ`2rBk7PCZ㶪(@:S#>pnqp@<y̾B۸eKꪑK=>q $cGNř]X1I9.|-EENwysL5bKֵ5FQ99T둊pYҹaJyحa k/qjA(:뮺eʻ4uaZZR){ŭcm'1|ǽ|c≬ƌi,+&l0ŠhQɶL;{4\r'9M:뎺 'Z֙3mncc12 h2J):™\tAd(2dP&\q+! Ιg"AD&uc}W{PAAi=d@,(::8j9U2gTufuAiJa=`%6*0 < H <@ AЈX04 GJ M5QIvI;Ԭclr-4r"5%sZu)d/=,\5r^\-Geu]cm|>i*Ǝ8`x<,4(8PUMi*`x4*`"珬hګ(ɕb1o}{:;*S3d"d" `t%}):g=խjδi9rZs|so]ޱ}gTsz/(j(GJ]ui%QEiII3{,2JeW5G }y.F[RůvZi,}5K.lٲ& 4ɦbqD@LL, V.+,p>228:- 6l>}UIUXIiY{ML2z)'ZMQeE>,/f-Eڍ0}fm.j<-6ʉ,*,2ge+9sֻ_m[5cQTMR](-.ʹVB   @KAu0l(:( :(6M(&iv]ee+M.-.,,QeYiYf (I$I*k$%ǎ 4&J6H2q_YyF ěi4rƷu/lZ\{L(ɢ'.`e0lpV+ "Hظx0  8H2q`|.@"$$<ёh8`٤O "a|t p!P5餩m1k֭Zּm! :0"at(UPd(*t,G*IeRQj>+l"$4# Ȝ@fص'R" Zֵ|ceu+eQTN[{lE:+YdM$m\Æ 0lUX⃃$:y^Wuc{{`N> w{߅#pVApH(>2 Ue`h&`&J< g*  \@< Nea h4teJ4yK*pr'N,IM4DDR,0 >׍TՎ4\ǎ*TRM8CM"@)k1m#ksWe4\)LΔ)[`;9³5i;DlnqÎ3Nsk[WB'i]u! ֻGNVaZҚm:+J:&;J7ysI) Bsu5۰xt\L5ﻴ:Ntj'Jզ{:NԔ;asGVyqڻZ+Q9NxqAVkFa"΃"0|%V H;JAP+7)3&L24 &7 A`&Lɒhq;2fL3*L4$ɺe]t$2޹\݅\sNvsg殹Rs9sg4/k:ֹYΔuO9}9[QLsF$@tyHC8%L ::).}Uu&zg˔%Ÿґ{euخk޹{w]"=wgձ|5sZғ6kvm仺g8'N8{9A!Z!`" p Zj#e$|[zТ@@@DLpH*.c`6xD(HAiN0Q4M$QU`j}E:Ih.i|C$.Uf1m4-K&I.Ӆ6i0ҥi[n,2-l;ky%ַ{{O98 yޯ&azRgZΜg9sw-s( d'.x'͒"-&u EEEE,%,Xa)bŋ K,XT*,XT*,XT*,XJXbRŋ,Xbń-X 44mmmmmmmmmmmmmmmmmmmmm"XA$i%D}9ԣPAaTģGʠ8+8rf̙:tsȂDH8 ap *H H]0RNNcBJF $$<)pѤh8M C@DPDdabP<@PL=":d22eE8 H&@> x8p$6HS*x)> `2deM&<`$E (qrF1"RiT]:) B*ȑ,Q1(LSQ.B<:Leqyj͎]u͝J I&2es`` CAh' ]:`\,YPuJ0zs*  UQTIM&0`}C̛X`&&*6yA'L.Tdvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@??+2GEBAfffL?p}2+3O7MAfff333?p}5?DD$??A>hQV^L@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1"PNG  IHDRc IDATxyչv2 223," "QAEE$q!&.5^s5,kM1hˍ FĨl]amfz^?Ya~>U99 pfLrfcl:a 1c5d'keH) h Y2@0d@1^O G(>9c ,y$cUdiihGTY#hmeƍxPUj0i9>W Mzv߈heM 77Udi-GkY#nF=lRƌx8\xьU%g"*Ga'#xQxo@tUUuL3ƸQysH<ǻ@H 2À>L . 8?2SeBN4(yAxt,cQ-@$EztZjڴ ~LJ6; :)QA(ndEôMIk1 *~G0i}5v-l.a^XYzYG*i B # u7_=ԲJ^xV8'!m[H# HR |^.Vu_vY2,\AYVM:mBtC@F wr2 `zEG]x.U:YNT?GRpBBג.>t,'2@ERQ$q-O(R4w]u_?dӊwb"e,27c_!yrs K`"caY e6ilmTr)DN/ds. 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UU <t@,.rjyl}4ڶe6eQ^^N,EQ8x _җe 3@u'.'|rk֬aǎ{IMM UUUTTTQU[nelv55?xB5rB񄌙P<>(E1s:7jP<U`i~|W3VعAJtZyݗJJ)Wc1 ZNr&U4²3Dݽz;`r_q04N5N<۷o]pWy`P,^uO%ðm6:;;immg %j̙3alZ<z͛7SRR~#-!544D<~:"e{d*wW\1dM6Mu+ma˝;w;cGަ6l oAutt xo{eKKˠ|l===}t݊jGk ^,]t@>z6m9{졡￟:jkk5kְaV\mFE$Sng::™ױz%j}! Xq@:A̹{f6sp{\㥨 /pK/z!ڵ+L@Gmoίky.å^ @MM{{(먭X.; H-mrx-l:W.F/\(*l۶kr]wq#x'Xf c˖-ڵ~zj:Wǒ~IW0KlX#o63ҵ7rWE`޼y3Wo*eC\yY~~v֭䓟|\t!my4Kl l:u =B]B]TNQT:mF}W\al.7nx)w\-dΜ߼^GAgױVZ!#iĈ1 =&~G#gQn'?gI ti+VR_?UUH2]άZq:dT U=͌)H?+*g?6կ>/ȹ/|9+W֒ͮni7k6C]eK+55 =cc/-*o6$f<-\t">y}w[g? q+Wv8Oٳk_ڸ=^**JF߯Q9{.fb1Je偱  3f=́>Ś50c@I ,_~ec=W_Ͳe4m҄T3gq]7dYD m˚Hlw_ӽ "JgC>ms p3u}{㥗^b0CE`ق>rW-ԣ,_x>LY[hyFKK J;:vtnM l;K`H8tћI頻.2^ d5#ƴ<B[dOf1*۩934 eq&fkv8,w{'=ڊgϞˌÇ ?J]:g4ѷoFKGW+27u ]۱=og<V---i&oozExYIOgxf:6fK枇#mz%*f5P(G og;3h86:>a$e:BAŵBg,ٳ;%=3Y6hY!|G6xCx뭷FwR@P()XѮ:%7|3;w,l~^![@n(fVq5n1p1XG>'MuPUQB0/8w4y vlE7D[2`x3㚟E UPMTӌ5hFib69jϋz()ov-3躉}1Rr!ϯY !P=7Ѩ 5(BEU4 VwfK݉M^ љ5Uٞ4+f5*:a&x L=h?uTi)%GLc:x_ ZrtD pC 6:SFtqZp2s1O:+_7 U,h)XNt׸6^wuCқƶ32#T͞ǁãraZǧ6>O ::0c1tKsGKLj7%aYz3au~K ʤMȸдj _… ޼֏ _[=;=J0Hoh{a2 G:C.GIgcs;-[غuk x{pMս"Qs(>\QoZ[&$?)8NZt͍#rQ;q2˓K͜FdlL -i3=OPO !B/e@4{ܬWyYV=z1`9ybDChr\>Bt= (-kZ`Ǟ!rDo)&$%vn滁ڱi:Q4ʅP=&O!PғwoYx]oې>@_ 7 0Lz:[ iHg-?UU--i|< <1H9y>#>M(BCQ5r@(Sow S`_A ʈ;绗"TT"(a)Y@'3v_/s?BIgsD bGtGP EQy/}6)+kX |,Iq#$PV+_eFwuFxݬrFhyj+[P<@2b-;a2F56nܔѣoll#hfmF1&8IENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    ꪪnWkUZjMiZ֫jWP֨?CkU5kKZRIU%BRZT!kUjZj5kKZUjNCTQVQjZZkVj#UWևTQBI!$HHHHI$$I $XW WWf#O vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???EE$??-bIMX;K@? G? G? 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l$$ft]CFF7.{-ͻO 33:3IpTH@zȘuY(]א$ XSAPTbt|_¥8ՅEMN4 ?~аD[T}aSj#Z«3:4Cgu N b+Eh|K}gO dg'G[<BNvج9s$sEr84"xgq[VZI1橫Z.T-H 'P5fu$R7מӃlf#EvPh?!˖˪㭝LR(m efAt؛¹'^WN5]CՃU=w,$vv}OLCgC_hY0~L477 3l.E)GnV}G#YjDPzcųF$w?myD׮n=gʄPsBpm(5Jg6]i}zsnlY )..& ˚I6sx=]seԌ&$˚^`ܘ rlbE55C;jdh6Yu ِR ]cwjNp>'T4_QJ&Tc"!SRRʔ|}jWYȲŒMvV>'fjY5(%IER0m<< a6Yv 2;W4)S-*ޔZQUF-9uvqrQ I:M6T -xwY^9YȲ b=j&Ōl(o\r.$2?!‰}^'pmi@q ;iw4aw:y'T_.@ =>aCYVBɿǷc,M z$8zNG--fAih>qMnv7}pYx_Z],t8ݝjG׵q !T}ò`Q{$HzO$5i?@<w1I8̟y%Ll3!t.u5&lM2T <`mdIA14?nky*haLaytQ\PF9meu`YYdPQ6jg]EaXdYjBE6`TNSǽ.j&t]=@Їl5ZdB }$ `<t#.LK ~.~7R]t{ &$xvwqŒwV$2( IAtԒyeYЅ,+ʪilMO 8˘ 1=C343 f\ZLww=OWw &@jVsՕK9x|b5ې$hIR4ǎF,I"O#buB3#XHz׎mGU,]uEA-qy8~6{Nw໫y+ I)>IA~D -ȶ* %epQI]Z{Z&Y,fXi7v(k&)Wbjf,ŤXunw;6v אָ]Z)S-H,ۘ%]5QIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUnWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!*UTkZ֤֚U-jjZR(EKEWBI $BI   !$HI$$IXW Wf#vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???X+#X$??@79:aS ZlQ@?G?G?G??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5g6PNG  IHDRc IDATxw|չ>3EZuYlKr q7`L3bMHy ~C/!!@ $8$$Cqr,ɪfҪ*~`g~y>$`/fT_^u{ ˦g(*PMeT+݄ u' EZG#-/CJo|1Lsu3)A( %BQh^<ǏGi #ʞ0vl:vvȳx4M>x+3l:*K !=э! 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XJRy$S U%=@Yɣg{õ3q /$ڱgKn{CIĒ&N%h]BWȩTqe ˹ n& quŷ!5ND 1NҸxcy"{J8X!L+uѠb#ȼCa>#ywniTTöroD]tG:vNgw+V.&'~MIM!#{ǵC²L}zٛHHp?nr^2d i HW rnk>4MC4t],YA3"F$I,ލ-ly4mbhS| +HH)-bmuArL;ή^VܽspTde+c5 -ro Қk9E? nBU6mM;>aQs:]Xݑv0;liYT\ՒBNG1[ӌaqL;m:3Pn^wW-lo<qW7?9'dx۶d*OlaxńINR+yR;߲_f/ϵ7e m=.7۶cя>#95`ۮuVumZiVBRk>i-1-f8w|n@9i҅ /nv? 1@u @̲61f@xս/F5@p؄1w=V*!(%Ӵ,3q4Z l U.{%uPeXp\ Awl~rk.vz@$Z5+T6?ȭD zeJLsrE?t~"D^m2sdb&цłMPXvDNքۀ6WZB~ @X13-~C:sA܌yjlQ 2CVۺN~Un>Nj g%,nBRB*{–qD0wPA8K 1.wWnWQTTEcc`'8^w/Jd1 vRātq3^&inIII&|%|U/MR\= ʲzg0eEfUq3ePa~UN:u"-ۤl!<2$l˦D0m3*SqycXVUQٴ}uAcpfxlKфFcIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    3?nWkUZjMiZ֫jWP֨?CR*UDTJZZkVU_T:JT(ZFZ֫ZjMiZ֫U_ZG?UTkZ֤֚U-jjZUG !$HI$$I $BI!$XW Wf#vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???TT$??R8b[S@?g?g?g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 93PNG  IHDRc IDATxwU)νg)2 UKuFKƍen&l1fm 6w`f~{y~<Ü<Ϲs @P {Z?Lߛax04M34 M}ۉ7}YmljDП Ulu]0S; MqM)%;o <7HC;z\ߐ5x=~<C` ݃h8 k3+|"B R1x3!4C%8ql@1+J<$H$v!E=E_}3cpk~ӫzO\B*v6 @HH  !Є#9HXw8zlV5 !%, ѬٗÄ %d\!|!0-ȓp"mZTrED  %ɑAIPu^]Ȍ}ԾTz0oEy'š1 yxL/l1y* RqI"ӇĬ(DzՖEer )-IƲ}H) xsO'>o`AZO#HK"\NJbVs0 /u[CJIN0Gt杔1d9A:vqҮ%<$J#L4$"0J}p)RJBǏ<%%!qm;r<rsqjʘ3~)%XSZ<JB|wx>G8Xx3zt!1,ˡ8l9|<6PGX꫏Jf()+RGzTߐ2r(F=o2}Bѣ mIz "8^G)݂H -;5TD .yR8q+ڭ!?^o]3ƚxmd󵲆>'H@g߾cm^ yzMv˦ 4+ $i!pX{!E r M Ëix[XVL}J侜%?hhޯABh^H)O5lo~o7h*guMe)>zgBսx7$z$M4MӰdt4}LLËh&qlVxU&<ŀtEN[X/q6,b5^LÏ b|  k~!)*ʡw$z:k%B#7TDK3El O^t~`&t$ɤ+()EqpGHL0^gR{hDוH tz!%'ղ![Yel1R\O8y!'f~m+6fӴ ֚݌)4MwٓwŬ(RJLӓ28dw1 $hB=ޕm'MpNϠ t@j$S.$jE9gHIZ5JJ$>{>#O?2<^yIm('#Oԧ-9/kZ;6p۱e'n;T7?ne԰)>L+o>$=d%5TReE ۱4'"'GAx7,Ǐ?h4R/]pSKAqHj*kڢ}%k)vN&oiŨaS(۟ԍE"ozАgʘyD 8MjfǾf(1 w;!%,˗ލi78Hs8m+_ZO!zPI\݃4zH2e&]euGz6֠!8(;Ω H`^uNQQp)E'.Kkyos_(յ457rWc8jvƵ> Tr,Sivo9|˟K¨ s8F;~%)%}6c" CXeABԽF_g,> M([9sPVVƓO>O@ ,6 l$''<}XN8{cP][ӯ7g:(ȣ MWvR{`Æ ?ӧ)>JyLh2ci齍*+lR@= =yg|?0kJD-uV~iƌW\펴G*g@]3Zm g/tJGUA$+>sLz:/lAat8nU 瞌 &P^^q.D ΄4'=GR܃V:i?S] n`; aO=TƱļI7ꆓI,p&0 NIyIYᡣS ]vַa~-ĭf"#O"B&5a<'ڕIu?ُ86nb1#VLmv^|9/2_S'ӉؿVƎ8q#gv=D"MCy>ڱfV|Q[yl;izofӦM<,Y\oW^y%Կm6JJJ-i7r&hCַ>kfBh)cGgoQ;Ŝ'zE-V\֭ömf͚iA Xt)@ۤYU#3}ټy3Ǐg3 g69\/„'=p@.2&hjMz!-W[1(zX)iݰao6ׯgժUi&μ.~E̲, UEEinVE[7aԥ5V%-N:o[3.otk7dYqv8$l㲅[E7`W,XTn[&} 6}?e;uy-~NeŰ8]M]?k)'m%%cutJD7 u7Ԡ &Tΰb .^ 9Nk( cV#?~Ƴ{.˖-K,[ò < 4 v۶/t^USk9!R:E;wM<'ƍy%?zur?@vuO7Xh_~97ڽc]@axy}!PߤQ"Ȟ/JR 2H^}NJ!'ϩːmo3ngN{_s ,vWZ뮻{M㆐8Xyȱ8$ålsTLn-%è;r&m|?`| D0&%#ؾKWZŢ<۬YoPx<̞=|+|_M^sf$k$C-VsOCyi6wOGuA È`ܿc[Or?"//!y3|JD+!/TҪ~#1<$7GMm~zE)@0}'xkƍٸq#x\vۢ%%%x|xL8CMCyȦ3}; *azHkbߡl޾cGwh`mj'7چJ@y5r`gXq@ @0$ "& ŁC{8Z}]l՞27ayZa 0uOa˹K+`jXZlllՁRA4MuX4Ek8Rzj목micTܝI?]7:MvvP /c奌A?]"OPqw}nƿ86k"o&k&fE[4"lܪ]g7.$yLF%qEċ$\N-ѳdwȺ` L3bwmk%l܅ɐ?v=6$awL?{ϰzVk.?yOW\< M5Ngw~sX~aVZ@Sy9En&!8C)KwP\46^%WG'*tZb@[bVzYdW)sFhMsm}hS.b9|->&'hȑ#yᇻޠ/=왗3ul#OceS4ʯn uWܹ ipʸy~UlmkRl#?\ʈ!`k۽bi!;"@6 Ȟ`;)Rұ{_%:=}e<,}vv'="N;7Cxok³ )%{mfeu ٤y< L;# QQ ]HmyI@-V t gϸ)c$a6~sσ"7Gp;b:l~%zBpԋY[[ xcɳ14 3'&њ+R&0L>OЍmhr (蓦bz<: ST/ۖᐢO/zgT*Ǝ8 ]744<G8#4x 7`܈O^θ BpƩϯfw>`<}qwdL='@&7H4dhopL:`f;?1wuWO<`m7AC"Ͻ7/zg.hjj+[Rrǘ#Cld{n[qDssgvGbtw7rFZTS/ݟF~GZ L}:nPr-\ve}ٽo;b-T V]R9.^|64Ffɳ1tOwmƱشuw*ݾGDX '7~ˀ]۲ߗW,rhQRT&ϺW-X@oV9W^/~^͑@Bs7g3no ˼P39{ʒVׇacWgZY]/ξ%~N P'x׸;w._җxndk;Z#ilDQa㣎l.m0: <_` k5f7`L$?? B0ӕ؞3H ~o`XXlt??w ᬑGJ}sf^'H^G?m¨%-[IH< 9vs=M7w kkTaED2F"^:ۮÊ@v̚|>ɡ;hjjЕeK!3!wBt+x{x'Oڥ{~n9zkWk֬E4Q 2I^G%H\9C&vXgMaE8w ahvYm2)YW$X];MrK.a ׍l}5tpPVk"w;-%#M5IDAT[Ku䇇$G7S/V;["k=OT,{4j5VUmF`ps}0V:N1k0NkfW?5QIPIHMhh:FCH-Mumꭎњ:6pC(e1cbfLZ& ZeI$ξF my⩧[aKTUMG ϯN::ٳ1bǏ'''%.kH>Q[ RPyl?#N${u StB4E1in^ɓ="XOzh6rDE!!ܜko?¥`xa̙455;2ҒH?ʍՑ>x!E _1E\x֍H /[fLZAYgƎ0q\{h3zgoŧ^G , w # /;ĉj_E'K/Cmc4Gi6ʝ1]Ɯ܉fM-4#,$SǜV|%b<}ʔ|rf9osE<&_X<ۋs|m$mPk)Lhdw(k4Jg.RάnMs@$gaEcxo.Sl22Q|ᜫx;{T9sذW_/C ַϾ7Bo\8?SۖdجN35|NӀO"}t-Lq;z\^oh'a0|#GKaW7o7oNHOD]Tc9F æp)Ncy?X0WyVbSmf,ǎ< \憤7&ѕKn1Ds$ zG"Fa>iȪ7pU!- q}x'4#"?@{~wpؠDܙW `;/]|F Rv&t8VwP+ 0rdW'I'%~ Uic 22PYQCx*yߞg%5V donhݔl4w~ԁb w(>O@pq?i;]!M{^:IOq,i $Mـ&Bn>mA,7M*u\ߦ̸P)c&s*Y;QZ0]J Cx;|GfSҜT<8  ok1 Atfǁ5 MUH!R.H̎"W^ye;1Y+W sڎ.;wꅀ୏'Wi<9A|ثƍ(Ⱦj3bK%Om1 fiHd^5T tEåjvlvC$E 3.Ŷv 4g@Љ=Oa0\EMnZ.\حss{tIZ5ȶH$3 Aڳjҩ'3ZvUp^Y{24]  1M~o;5]8n(1۶z˴Di vweZ7,iu6NrzOހ 8,닕!P{9m|Н'H)8vIkOTa!K-t~wB4M=|FmMaBIHpwr|3兊ӈ<ۣ*Ow&Riשׂ'KKWӒU-J(fotǑG#MzZ2ފJ F&yݝhwè^$}x|xD@<ü%R,p!/ݠn՜'Oĭ^:ٓGGmZ\2i3 9 4Mc^ǤZjDDh5E7b:7[~#1dsO3eUNtcCUAbf$J:e<Əeݦo%@Jbĭhu'sÑi&!j4 jj9V[MCC]n+',l8M,ㅵǂqO8J GGر/{;ScR~CvJGe~5;143h `3BkftAvBH $P]WN\j ƍ鮾PZiMݬ^c@RQ?ۇF8m|hBU:u1*$ %Wĭe8vD(;䁔eZW]tW[q,+c8Y|1`SXRRY{)efubĭK8Ͼr%,y M DU?h/b;q8.❛A |[EC1ryT <JN*4:TP 駪qkmq%yBq4^B< M5yq-U7$R0p4t혥M^KALÛv$A8LƛF!ҬO~畭Ihhan20rŶ#$\b4PB A.BhĭʜHM7fh"]G IVP-*m0 z!uV)(fh{p1hnd)A~Kig>Kٻ/MFhi44Uwy(Thr 7` D>߲(ch6fi*wkymĠ#OKD 躉_eŐD:XMTPrS zYsB*,‘C3pi t܊ba1!T!OXe+)c(FPs6a>Ox +KvФ悳H#MFl;t4D[BO<}) p_R&Gb0Mõ{5O&puvB 8K}ݠZ=џª 8Ia6dBkhO3I$V y7සF۱mͻL ;t :)e#>nIMM< O!)Kφފ -*cӶ9m Ѣ.tQ^?y9]sSƜt[D89<4M'< 싕pT!3P1x EE4664 LhYdɋzDMDx+iXLii)( :Rt;c&nEiԲmﻟg9Xhs3͹aabfkn ʿm.ő6h#~ KϟۮZZnA"^}D7}|~>?E%6b14 4MWy!-=lO0gI̊ik}?eũo%"X%S5CEix t_#|^/^O{^*SPnn){#r䅊8U9V{Ja^?}b`ӺIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    @nWkUZjMiZ֫jWP֨?CkUJQR*TRR*UEJQR*TTZ'U!(ZFZ֫ZjMiZ֫U_ZG?UTkZ֤֚U-jjZUG !$HI$$I $BI!$XWfW W#1I?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???^^$??@^JB9Y@D@?@?5?@?5?@?5??@@@x@x@ ???333333?333333???#~j????333333? 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(5S996Y$BB0i`sY²ZBwc_v9K +Ok(yHiIZXO)A_A_IEI#T*V"~b24s;Mei}l\yۨ~r67(6mOM-SUHgo@HѴ5'j+eW.4B^\<-.RXDr/::MWġL2&]f9EV{'*J$3 3E 2>|{wˇٛgbڐbLKh=-tS`Cqm%αFz)hnj*K<lXi8US{@UL[,+ttaQ+}> dcgF68G`'eͱ{^37tVcIpgU67,D躱(zNF(ҋFӒ8rj+GHClE3rTV/@%d^dpiNS3c7ށs&հ!Ӽ}AH&cp[p:<4.A6H;f+g;[u}P ;KJcKjFH'CuyzhZp9Σ9 XF_MOr%fF3ZRZpdKhi\BS,\.aEw-p:A`'B׸fpqjdIfuHl-l^}'osR s61)q VUŞ#/y͝ah+q, @74j"r|m7YV( Ts۳N4-ibJiIf4- JÛx^4=EJK,J@jVF$2o!HFq:؍%Ǐ}^F$nO A-N?ް03{;cūrnc${,MK2ws]Gtm̟hbN5V $#KMGH/Ba!u(Xـ4흛>i$+@a dVsfPҜaÐʉfM]aN[ /6P}R$)]w1oGUT< Zֲ?NI EVQ3#qI* |\6v(Xf1.Ŋ`gLh,XC}am ٗS[1FJ(SP]Uumfż0 B^g(˒4Ɓg$iu )/$+Wi{ET52xB-B-t{( pيD{=C9iz@Pow\At] N]eKVrȈX u3BcF*TŁ$)w%,V,J|+{GŜYw ?]9l]ܢ?!xu~ ˇ,$2+h#.^(p4ڹ("Q.{9 ճ,hxѻq{ZӀTlre$$`m8YKfm0h- ̈́+V݁$I_Ae*˫>KX]-i/j:xl[L6SW1jR]t:Pvy%;8q +› 'Cqvh:܈^f$I"w}d+}(gZi,)Ȳ̪>K݄tg+hX?D3taQաP\?bV ZryM3gRVwvwɽ^OɳY> A@ iϲ9}8cn8n(n})gDtjʛ8?yeOn-4e.n$d45 r_[VG62.^v^53me 8JU<}F2 Dڟa<.)@^n99P7h?! jix\h,F 1U&B65&/zx}G~DRKM$5csѼ+M1np;D2X$qnLoXvyM)1-KʸAk.C]vmW-*`[9uM]O KD( 3ʅֶ][xt ΆaP/(x g x`M!i8'ngnR\X8j`~O)81%z|/.t ?xG|X~r䓏@Xp5IAU~/bIǑh1*DL4 =eRio]*n4"3mᔾc-T!HṪ|OF$Ol+Hu,ODI$=TyנȎ[`h<;3FLEka c>=nl <X?.4-t2!TlBT`hwHF'f3ϳDU]Cn{`Xv I+ o C4VbLr:$) vP[rcA'3BHƈ 뾜0xXH(4ڶ KUyCx1rvĜU  5 )]nl)AFL鯑k4Tԁ$!KɒnSJʤKx݌zz.8׬'IDAT}%WϤf6%*>J<CӓhZʮl>T;fsd3Y2V@ΛGGN(TҨnDYNKf]ok.h`NYk KH-0'g,56r|vYHz2/-5CEdIP<8CVi)8zօΔ Ą ˤ8trVFID2N$b0mt/LF8ӑ.7](ІMYBqxmXmIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    3nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!*UEJHRRkMu֖_QQDj?IJ*UG !$HI$$I $BI!$XW Wf#?vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???N N$??`(RQhIJ@?@]?@]?@]??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13Z,PNG  IHDRc IDATxw|\WNuɲ-Yn-1NuL $ % ,e!XX^]6@ KH#@*%i"Y}є{y8wfdIFb3hts<TEQ{~ K ( sB `P @Qy߬:@םD&Nkfۛl|:@K~vD` KL q~4GزK?Q@T'd,D!x6 W}vp DZ ,}~38`Aǧ:X}31x(*B8'F8bmv,BP;k{!@s>gQT/2xB' aIǶ-c u ߚ1vp(V#̭ZDS;C^?*TEEaρX0geAǤ ¦O2qq|'{COt?0akMOFtzdHYyaƣ %g@Su@r Y=IDmT6T/P1 ?( T=^zyqX3^ɊӰ ۶ɲ:wMpZ9URYjï/ʊߡ]Q+<5꾮8<Ò蟮U.뻞CEc[Ts昆uʪK>3X?]+B3OsI(( y3XB"K9m$P@g@73Q`l:Ziil ˱0u܍eho~s+(Yr=oyaEFgEq;ZK !PK>B"*ʪuy q7S^<EQˊgVGwVl^imysk;sO@S5/$qlP[>NbY)t|>OϏ9 XNڛEEAq%x׶u0E PEQع tx '^՘.9U0t}]GMIA_wR?tq˴5smdXp:fny֨f5@A/躁FJt4sL?d6|q\.dBu,;5m[oFݦp=}]jrϰ׮_Y:$m˳c͟gf.ȓIEy6('_.Lq k(\`nA$~'RQ 랿u{g؎g$q_ 2 e662Lxs7|ȜE'| ma3~|nEÖ}>3P#!g~+J#uWҩ~4{#Wɧɇ{,!ܳf %}bT>mƢ,whl3̻d% ^w]QBvGet2=XB)-G%~Jb1jJ]s1ʅg<> t9%޾nbt43ErJ(T kwQG,"9UdP3k7UHuWv>E4ԐGBfph:s8s!cȡd_9Zp# x?r\!eKyFs,T*J QV4,"RRz/=z[tƎT.!*C <}$g$4irn8XBGgUWsȮ9 9rV->!83+HHnsu;ExO֣(VQ^4r=~Xw)^q[kgB!Bpx@fQu~Med"t&[" ӗy;Ffg#tJQg=U^ǂ9}]h\tDBvDj~Nbh&A0M?)+- ՗ Oh(B8,wQБ]N'Pjf z=}9eEՃ_P7ml[wB9r}?"L޳B(B8$SqZϯ62HݫiwinK[!zZ1M?}:ZmǦA0H$GdP΂8@!@=}߄ό}*zeHsO`[ umS{CAA @OH}#躉mq\c͒9)Bض jLQC!̩4/;,Yȩqj/ .u?R9eV--qb@O%sI[Ib~1 (*~3@J D}j|FH%E b"/2etۖ+.[[&83 _*%Ѫk z޿?~g%a^G@躉e=m;A T]e)/Х2.WF4TeXvZq9'd)@Nc_>nf!}sykG%s(Lʅ4 BV 2|fNfEg܌ =Q>4qM"U!_KdМ1q2>EI˓_X <߹#őJ:c-G]~tit4QQRպ)ЊFOER ݇$Sq,50t+fo\n_HGBXTw"_a<NZ/08Ժw8غ&^"b!ΔVM@j=tJyrlcA&JQszǁs==~ /^R? ?;}{CG ȝNFbׅe%I[iW!톚蘺xH%p Hܟ5Euf1bM(9HP&tUQqE׈ZLIEZÁbz\9W-BeK+Hf>ع+saۖsU'bXvՇei<|[eaZzh~3ȇ._/2R!#MSe'I[a4*5ٶ LTNɅ 8K<Y?^=5fd'BMհ$&cOk$zZin#{i#eȅ,bx"!WUPom>! Ȥu{{&\vtP2x#Q GNҗec =:o3m]9ܶC$q>ظ*Hy܀L#j qhi?&'B**/n- SvDȒe4,?0_x N$'A_"ayM력cJ"ĕ| .rfBn"S".4\}$.C g ( WR0 h;ѿ(V!8SW)--%He~|>< \~0ynK!?|]=Bԍ)*Kj\{w cӗ!o',(\չj78N)=Vx흇xkKy91O3_d)n*pֱdpdoΓO>Oq&ܪEF5$a羭]v%JK *w>öUYZ2ֶHx9+UHp9nL@U8ض<2 KN;qYV;`Wdd3:3c]?cqrJxof\,`( U>2C;m+vDBii"|nv桠I[ɜ@ܼtZ0t$2rjg$}XvBUҟjk=1xy {8xg(ɻhfYFNW׬K"(+|9* WrI(.qҤdNP[؝12i^qEb'፣ſOS\\ŋ9syK4f#6mN,3 ===b1E"K_]qRV2+DtUT),Uʂ'P$,++MQx_7#ĉTTG8A6p_#LSVbeÆ t'BɨBKlHAvA;s]]KyiQ%\g!7O(7޾)Ff S\ x2Yu1t+Ҿh#ٰyr3PX}M;1}% IDATUsI'O}wҞxg\ɗL*p#ϑ 0Dy::;v:&PQRCAx$I[ɂf0oj& & PW/JMVAhhUYҥ<e#;L,jQ5xg ݿc[뿣+z_a׿5a#!>?o ^?]w3FuzGrKkgUeq2r뮻聣_+*t87A^RQ:Ӑv5nW~OGRTTOoR\>~gpI\y9/_DCDz7FS?ոo/hC$\v-_=߿{jT7h>h2 K.eժU4yTDZ5ܾܹkn-f3Nx[)TrEkgyvy7tcÔL\W#؎M#Mn݃YplZvfq>LK{#Os@M'̐xY7C8Mky_*s /0!OP+җq^x?_~yGXxL9Hfzss p60cyeP 4t5O}SWϒR gekT7AO y>\18~(B*]۩YMSE(PD8PL(X kK.deiu?-nz1m3`_}Fxd5]3@Qh:.h"1ms"$][[K(bɒ%;رckVC[ېc >3 3C f`>4MJ L+ ^@byojHbWgA0Lh T/5w1zL|Ax޶yؗNi׬3?B8PL8XB$X lvЅ z:OWJ$Sq^RVd:>hӿ_]Kelo`P_V_%@ .iy޿v0XR}Đm|_&NH$H&|;|!tt0L ݏt۹{ZiKLD^ݬ,Lv$G -oq}>0C) sEt/)YkPhB-3䙢y @n!q4kcaZdLWdd8"M4f, ƌ&|F/^(Mj܎ś&L+T:ɫ.f3͐Kĸ!4BfW؎Em\!4C@pmܓf3 q;d/=z۸茛ǥ4F_]7g51u~_*Orڟ!4F(o ”ϥx=0);rg3͑Q0EJB"|f]3PU݋zfh{Hΐ/)fbA /lVU]UzU0LL#i1 [S|!_,2(jSKg3@0%ɘi5baZ)(G| yf0b,#Pp<3 5kf31`xbyc<33A,ʦV.>IENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTnWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_JR?Z֤֚U-jjZUG !$HI$$I $BI!$XWWf#vbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???__$?? VV`;F@?@0?@0?@0??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14!>PNG  IHDRc IDATxyS7d`a_UAYEq}.|JJZ_k?֭jںW-.( 0ٗ̚dI&I2If@/ׄsN&9Øa3mgQ۔Le@ENVϾb'qAVm* hjҀaʳ&5I/qPN}QLf~?mc{9Ǔ8!Rpk4T?yKhķ{oX5K螓 Ycb谶bdnI/$KȒQPNk} n_ Y➴bPN֎:v#WmO q>㯸!22BVijhiurʵQ۩DA|YWe̼"tZ=,bMvsiY4볘Tz{nhsR%?,by˘Cc_ŗ4Wb`̰LwfvI!2*QM~2wj7lAI+F ,YFVsϾOtl{K~4jUJ4ύ@6:COA%9)<JԐKTwK^$ُ $a.\W0Ez]&Z!Qr{Je']3/o^>fcJF%|Ϙa3A\xN<>&K3&K3i iO?a>>tP6jQ4w4:x}&ЁZ{B#[o9ΐ'52ɲDU^JO9*Fl3mbTj*Qdn蠩*fvs#i I9. M\4]+;oa~7N ZK٘gn`a4P@zZI9^Q RjrqL *Y:<6fcM2}'<Gkw*hh9J>|Ln1bw1Z10Yi77@rP[|R/ș.gBzZzm:+[>fcIs 2( ,aQYyڍ? < ,! 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J'Fp(0Aq2eܨlj#QCg#0Cs{5++vGm +L7sbyD5^k _z(1С_Dtsޤq2tedmkbpXlmdgQGl>r81x2 :/gP.KJҎqTXJqR;yF~HzB٘E Ap:mߑ"jGtj%Sy/F +(``a4w;D0Hw!LHf[kJyɜHOFR! *QJi~e}3zc7|,5tz APoQ ʼn \}=r0%3t8E% "b!Nٜ͍Qc(,}Zȯy[a찙߾ʈSe),&k$)z٘EGriUE3a'7LvF>Nwd怂m )uהhIUCѵ!=-.YJ*= M)€fNX{#']qD됁T!kdmXڝX^ͩ/qڴ@A@Γ[=l4(Xlm%/ #[ dv#>UUS{lk#IAH.FeQo-/N(Z :ԨCg-nBy"PDpY$_ N~!0dfOZ G~AȲLEݞ@Q.d$yDQZ_9 }R~u 䘇SȄ0tFs36C1kӍN5BFHNq0{)QzCQ3? u*t鈨71ICg {NTX@>.>/fE3.ڍ\OC[.[~XX8Z*W0N J6?+*޶|;D?@a7uWu+=Hh47AUde3c2vOpt4Uޟ%>v)vM's(X:x iٌ,I9 fN\km}QNQ7m왔^HxVwz񷖿g߾m?mBZIkG]n)Qh1{zMjv?Z[~|\4NP,,5nf9,!Z9skZ8\ + o0* 3' <9mx6<?/ԕ&\.Dw~O(enzIe&I6UY^ũe#  V}TvQU .:)dJQ.FOX@֢e%!/0dIQIIqQh#4U2u}<1@IJN h)(ybIENDB`move=1000;blend=1000;3O7MB11   nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_'&ZikUUG֪֨?! $BI!$HI$$I $X Y]pB, fRI$!B""""I$"""""I (AUURI$""""""I$P!P5RI**UU$$"" !RI%QP2I$QJI$TDDDDDDUI$J*H5TT UU$I$""""""""""I$"""""I *IUUI$d!BI$P!UTUTT UU$RI Ȉ!U$UUI$dJI$TDD@"""I$P!UTJJIvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc613O7M    nWkUZjMiZ֫jWP֨?CkU5kKZU:QDC֪5'ZkRkMu֖_jԝWP֨?!Zj_R?TT$TTQRTGEC(@@@BI!$HI$$$$$I $BI?XWfW W#$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPvbinding site for residue gol a 184ac1]c1~binding site for residue so4 a 185ac3(* 1vbinding site for residue bme a 187bc31~binding site for residue so4 b 184ac5') 1vbinding site for residue so4 b 185ac6di1vbinding site for residue bme b 186bc41~binding site for residue gol c 184ac2Y[^b 1~binding site for residue so4 c 185ac7') 1vbinding site for residue bme c 186bc51~binding site for residue so4 d 184ac8(* 1~binding site for residue so4 d 186bc1Y]`b 1vbinding site for residue so4 d 187bc2]y1vbinding site for residue bme d 188bc612GEBcucuAFԟMjOR_ubinding site for residue ca a 201ac1ij1ubinding site for residue ca a 202ac2 1?333333?333333?333333???????@???M\TM$??@`V I@? 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Ephe RYXZ\cY[ZY]\^_]`]a^b_b`ad@ EileZdcegkdfedhigjghlA Bser elkmoqlnmlporB Eala mrqsuvrtsrwC Eser swvxz|wyxw{z}D Eser x}|~}~}E _tyr ~F _glyG HasnH Hgln I HthrJ Hglu K HthrL HthrM _glyN _lys O EvalP Elys Q EleuR _leuS Blys T _aspU _ileV _asp         W _val X _asnY _ile "&! #$"%"#'Z _thr '&(*-')('+,**.[ _gly(.-/1.0/2\ _lys /2135:243265768798;] Easn3;:<>B;=<;?>@A??C^ Eval<CBDFICEDCGHFFJ_ EileDJIKMQJLKJNOMPMNR` EvalKRQSUXRTSRVWUUYa EvalSYXZ\_Y[ZY]^\\`b Eglu Z`_ach`ba`dcedfgeeic _aspaihjlpikjimlnommqd Eilejqprtxqsrquvtwtuye Eileryxz|y{zy}~||}f _aspzg _ser h _glyi Hleuj Hthrk Hleul Hhis m Hphe n Hleuo Hlys p Haspq Hhis r Hphe s Hphe t Hmet u Ghis                   v _lys           w _pro                x _lys       "          !  #y Eala  # " $ & ' # % $ # (z Eleu $ ( ' ) + / ( * ) ( , + - . , , 0{ Elys  ) 0 / 1 3 8 0 2 1 0 4 3 5 4 6 5 7 6 9| Ephe  1 9 8 : < C 9 ; : 9 = < > ? = @ = A > B ? 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C B D E C F C G D H E H F G I H K _gly @ K J L N K M L O Bile L O N P R V O Q P O S T R U R S W _asp P W V X Z ^ _ W Y X W [ Z \ ] [ [ a Bcys  X ` X a ^ b f _ c g j ` d j a e b c ` h a i f g  k _ala b c k j l n o k m l k p _glu  l p o q s x p r q p t s u t v w u u y Blys  q y x z | y { z y } | ~ }  ~   _tyr  z   _arg    _asn   _leu   _pro   _phe    Bile   Eala   Eser   Eval   Eval   ?bme i  _ile   Eglu    Eile   _lys     _asp                Bthr        _leu                  Bile                !  _ser  ! 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