\!83.6-1h/data/swissprot/ 3IFS.pdbdupa 3FF1.pdb{[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]2.0 Angstrom Resolution Crystal Structure Of Glucose-6- Phosphate Isomerase (Pgi) From Bacillus Anthracis.[/h3] [p]G.Minasov, Z.Wawrzak, O.Onopriyenko, E.Gordon, S.N.Peterson, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3IFS" target="blank"]3IFS[/a] [small](deposited on 24-JUL-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3FF1.pdb3IFS a_3IFSB1  3FF13csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] 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SQDHYPT(H$a#AEH%Z邅AE4K$(0`)L)%Q% \\TD24DFb%DD[4J,\ͼ =D)c(5'J SDШT"fm&+^҄U]{UTmW3 hiSZdסS{m]ܨ`xL N0 e4$|\+$T=^}&ffw,ZC45[A@t, JRQeADID4C"I%QQ% D%FsʱA΅4&` !`xQ-S]̤KT!%34"bMmzڒz\h;;*5-ah [x(8*}1w3 QeP\@aIIRJP)HBJ BrRB ms M޹h5빫DIJRu%':0HhBNXԥ(JtLD\4LDK\3,s:Y,ʔQe*BLPh\( Qg(``T(A*r $i$ eA%(BRR,r(H  $Bdr*RR*JkfRF עTjj.϶ow:Upe( ( (,( $0D4HYBRJK3)*RfhIe (h%Y Yg9eBR)JT&T*,hdLLJ3Eݽ™(iiiiKD3JJ (U2W^ƹvZ33313ssiTjթuZgZzSz}ONj{γ]VUUaν77eґ!$p.Bl mUg$D:nwzzwzzQ!p^١%eʆiT‰C2,PT.S%1Qe P%,hh&*3r3jkFs6֣U=-QZj6k-1w37RUToOtUK1[gIgqz#5Zb@%@\ꪑ"5%ojqZᔕ$S%)ffL]Jd&  s4",40*u)JiڮuUDb&CffP^zm^ӴLL( ^Ibff&^]^{,XpzZBw{5VUQBJRR\L\^}[\DMJ[(e3!1y7ksՇHw]V5;BuU*".&]LAbtœzZ.v%Bu.b,(EީR /SnnZB=jIJOW\4KM(Xx\4hBE` иL&CB`P0XÌ0F $9"J,BZs Jb.PӮ-JS4NQņogtZꔐVDFzkzzҷzbvVVRZF֧zY+w[ƪW3*.fNBimV˪2p*TͳE޷e%*J(JAcTjBP鉘e&a9UjYTS*z&sw]=Z=QToT]x}9ިzgmzFsa@1n}f ҩTC&mW7]˭waLUޭekU]ь9g8ZSTrj/VץoZY%\MA`t۾Mޖ,Czwu֬կ>(P`Vft”D3BH d"2n뻹 e!1“wYS ́E*RH%)J\),鉢 0Pxx@$ \ H @$ $@$@D  H/Nl     b{kց<8x‡$ri zZ0M4 (=-ynie=8h,QikI,40 q\,(zNin4{Ye %'9)q 4G4i$HbCÄF)PƼqpƵkBҷ ,cвL1璡䩥mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???tl$=?"'D@\RfS@?W?W???@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition3PNG  IHDRc IDATxwE?=XDT<t^P<=oHFQE0!(JFr88&T NO%gX؝lbUݙT}s9wCqx8F/K^=Y>=*w~:U` 0 OJLj0l,D6s׿ ^pe#9Vla +`Ɨ^k Kc= 櫸zm81{P0n3X0ߥ]^ x*NA'+3o`1pW2[@  e~zֲBQ˓#B8ul #@̴_@1H;HIOtղE 1n A&x8';'0#AQ]%. 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SQDHYPT(H$a#AEH%Z邅AE4K$(0`)L)%Q% \\TD24DFb%DD[4J,\ͼ =D)c(5'J SDШT"fm&+^҄U]{UTmW3 hiSZdסS{m]ܨ`xL N0 e4$|\+$T=^}&ffw,ZC45[A@t, JRQeADID4C"I%QQ% D%FsʱA΅4&` !`xQ-S]̤KT!%34"bMmzڒz\h;;*5-ah [x(8*}1w3 QeP\@aIIRJP)HBJ BrRB ms M޹h5빫DIJRu%':0HhBNXԥ(JtLD\4LDK\3,s:Y,ʔQe*BLPh\( Qg(``T(A*r $i$ eA%(BRR,r(H  $Bdr*RR*JkfRF עTjj.϶ow:Upe( ( (,( $0D4HYBRJK3)*RfhIe (h%Y Yg9eBR)JT&T*,hdLLJ3Eݽ™(iiiiKD3JJ (U2W^ƹvZ33313ssiTjթuZgZzSz}ONj{γ]VUUaν77eґ!$p.Bl mUg$D:nwzzwzzQ!p^١%eʆiT‰C2,PT.S%1Qe P%,hh&*3r3jkFs6֣U=-QZj6k-1w37RUToOtUK1[gIgqz#5Zb@%@\ꪑ"5%ojqZᔕ$S%)ffL]Jd&  s4",40*u)JiڮuUDb&CffP^zm^ӴLL( ^Ibff&^]^{,XpzZBw{5VUQBJRR\L\^}[\DMJ[(e3!1y7ksՇHw]V5;BuU*".&]LAbtœzZ.v%Bu.b,(EީR /SnnZB=jIJOW\4KM(Xx\4hBE` иL&CB`P0XÌ0F $9"J,BZs Jb.PӮ-JS4NQņogtZꔐVDFzkzzҷzbvVVRZF֧zY+w[ƪW3*.fNBimV˪2p*TͳE޷e%*J(JAcTjBP鉘e&a9UjYTS*z&sw]=Z=QToT]x}9ިzgmzFsa@1n}f ҩTC&mW7]˭waLUޭekU]ь9g8ZSTrj/VץoZY%\MA`t۾Mޖ,Czwu֬կ>(P`Vft”D3BH d"2n뻹 e!1“wYS ́E*RH%)J\),鉢 0Pxx@$ \ H @$ $@$@D  H/N2    44wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwq!H -Me熌98 0ƭMg-)R)B)bF=4jL)H4X +94M40AÆ CSjM[SM4-AjgF!@ Cri SSId"(0 `H`ĎJR$ IF D0PQe5$KZ%Qӎ$aĵx )6 (ATQaEIh< SHHRA 1gc 51,ʼn0ؤbR !Q k @Eņ) IjdZHK54LKEԚ )E&҆0DDZa$mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+3FF1AfffL?p}*+3IFSAfff333?p}'?~$??`Q=JD@?@o?@o?@o??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1+PNG  IHDRc IDATxwՙ:dehHB@B&,c.8\l k{vc/Yh c0`0I+ f4:VTazӯtuW:wLRɧ*BۚiU\ix};by" ;>*ih)]I4bϑv _$!B"!a_40 4hiԦN4]Inj80n_@Q|q4polu|!C!! 8w'p^ NLAQ`mF3)L0;nNVn(pHǹzȒr|?S]/hj=щ8 yB-ic&8i-:+@^:e4 I25opkكz0MA"W$ʼnurdϒpRǑFi82a>>TͷGgpZ5c-"">`wmu{M 15uvL%+/^Zh|_9i1l^ ><%E-]15iB(҆aR>g(>ŋxxϟv粉gɜs)*EQ`$j?_  XŲҦ$$dكGb膆K݂"+& `r%_6ϣ$H;$3k֠@= ^B`&Q5aIdSᚏx\H6CCUiϧ#}'r8qt.Y;! 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SPKmLmU0lg߼=  .Vo'F1 _mh8sDŽNM{|qhjjD2$" "K I<cg )>8ʜG$!p7!@@~Ϗ$$zfh_C1 -6G83'Meto$q6i'7ðǍ4 junK0s/YF2I0_.`>/a1T-y󭕡igQx?ڄƉZҨ =b`Lkdt$')23.ףdcY%on{|X& Iz-cEȒnh"mYG!KJ<B+`eG2NQlݶq<0R} 3=X8 zV:70!iG9I҉ȲBmáne Uؿ(`7&ILڥ]Ot_5lUNZgY<}Y`c9()MA~)ϾnHG>#@P]7_tNkNW?{IM^I<,`ąC UY\N~^O?=+@ bWߊ|5 KL0#ҏ\|eXC16a0 &W0$nBL #"-RBT۝/V0J '7S0t֦f]Уuj{NS!S!O =&ϓGa%+wyyxD֗>y!ybx"2ƍ5kV 2og=bڤEL5՝7#Hj?u!ʼncҹR\8F[kyMHX8s-z+q͞QE8!iZKya)Jߞ|x'owSrꬳ*ߤysxqV/@~!ͭul:Ƌ>kU3p GNXȬ?n3EoI$AQddY0tqHVc$Iz衬6yz g|*nh44ȉ]_/,;J1 /|钟QXXD,#g('-}rJy8f"<{-p ~3S` sW\ϛGGzm{d}ia:Zq;;y.;zh'mXjaDg& m⪋~@dbp+h;x{_W K֏Qx$]NGca;w榨+h,Ds[ y[*X0LWU$tO30_r x=~<7¢" )**G/?͛9> ~GQdAEaP m'k>jeMhnhȒVRl_e^6ٛī`EꆁLj!Z8~r/~ -Ֆl&\\OҖe]E5܉8'Ӣ#m%t(JLq(ߜnO+'-"i $8k*OG o>3N(flnHMyZ:g=>_>XP2' &^~e֮] /Knw[L G0PWo>73' L6{]xfL^_R1%mG`^44w:wKR<& v +$?)>,g&(aq7|3ykƍ}TL0S,S6:Yi 7``!hl_l(5wh5Z6aLdFN~& f|V1ojZ\eJHqؚ]ERPݴ'GSp5q8暔Yln*&VQ(c¨JJǍjPp3 փN[E{0$Ά[5gąJ&vpæM|' w~3psϥLw}꿓wV" 'D|¸[rB-1aЈ3b%pNHmy`bIܼG>WxETr>.s MUv;’@uMG2Qz[rPC oOMAu}&%ewm;ƍyͨZJ 06yA+Ku%|yμwa=NJuގHWW"HJ#ش0ާ_Z|FSdN-l'#4&Fhhh F2ʲ}*&OΧ 74I X}0բǶ2}nv5#I+M,o]/GH}Yg+pHGL;Kf>@ 1 BL]΃}9eYkI.BFӭeM~gj>.. 3L?^I9YmHz}#{Hd>u7xr0=l3K Öxdݒ1LSg?qBMWDmxOFWy2Ń@Ӣ($dt*_ebjAIb@ i=׼vEtWپŽ}B`b_y-:M^!~f' 5%WJB>usԁ5X|tp m íhbMUl-D0JcKu`e݃ߋ,{4=+< 4r$F07rߋ,{:U+$Ԭ,שbaxj\Xo)KUÄ60 4=MɠuLzLo()G4z=\֞,tZfQEVJ{u9b۞W]HJKJz;eK )A@ Xw9S}< Ӡ~8dh&ҝ;q{,{pj~9$9ab]?鰥Z'{YhW(vE񦭘in Li .'{Lbqt]ؾ/>xĭ-R) [;Q5c-,)!(-L/6|ǎl|мyc<_AFouVVT۶oKz;>k>l'%'ObmMI lԭ{^͛y衇(++cyidzEDAZ1\v~w̳ -BK4ZA~k|@Iɓ;Ѕ0|^{Vw;KA$SR(@A _yiX^B·6;YV>@I){ZS/~{zX/[ƍ·aZPQ]#昲膆qL[: ܦ/8&=DygǾ0m[;.{,{}gӹ41q 9|l/nx,°; v AjYSsvT-<(qhс}ήl#^p˄I͛am6 o2iTn J0ܭ% @ݎSώ(-CQASOCTLSZzR`En߾I~wcEyc,=0%%%RPP9gz9V}S91YD% S2;j!L`|5y_,I3쩧Zi3{G ֭[Q8_瀟b_^z 6jsc5/+g/^fTΡ8O[jӻtLS:90tZk/M"q3= ^/aZ=4[e0"pĚ5kxWx:+N+^;ѕ)`el8Jt]ןp%clWPhnn(5 uUwjCu[tBQ?O΍7ȕƂvvt<;O VLJ^tK gLuYX$I'W#ﻟVmۯ&,<Ȯ-yɣknD]{_? āxTC(]ψ8iig;դ0M~;jeZ.!FK9re''2fd{$Uq>>Vāa&y~/%/~ nf~S⒵׻fյF sJZ%B+ _^cHO=4'f\ y衇x8;wꫯkR 6~p+x"F<-yD7O^g Uv@:"_a)NȔ80$ϊ+xCF,YBaa!g}kqpފkؗPϓ$) I-=({Bq(@^Q)]3 iN>l$ψ#E̙y_&Vn]8HT gΓ7dk{U-dJy6\G,`5YRR& +Y yzA&_s[F;=tJq_هm멘cA0S|^W,V@a蚭6.bؐ[n< |7Dh{17Y$6]aΉ^~b* vrM+\* u[_̨ݞ03n.+zH\QQ5"(®klذ!%4-F$bYi]{eէQ%唏UUxW9z"Ǔ&~ll/U>nߟyzۘY-]l}z+>{O<׿u~MM@^eg-BfϚK{{L3YmAW\Wx<*?) ^OG?,ͮ6G?eee?~CKvh>\pƍK.Iz͑%9e3lӇIŤ\qUy/xV VN0?a<K /8N.9Um ꛏtc\]+^t)iؑ򯾥kg cwֶVF6.6mWNJ?uի={6gϦO Ner ôyDI9`{㘥*w}7sՋ.b0~o>&=~ټY' y~(|#?~vEkY߯._ӧ|rua)-a%咁EETڵ[Xpjai5R YUaŀO4eVLJjmicɜy1MjpsէVm{R40%%ˮ"zKZYl%O ih0] `?1lu3( @74[ٟ`>YYiV,[޽xkRtŠyê?ZlUD[3<6iУ'@#N'I0-ϳ#BasFwsu[<DY!7O^|1j;N!U#í|܏ݙ`ɓC8uyZIL9xJy>aX0c Hk8x|{9|0Ĵmݡ r`sN!GO&OY r`Ҹȉ+.r!c +>Yȑ'#O#G2F<9dyr91r!cȓCȑ'#O#G2F<9dyr91r!cȓCȑ'#O#G2F<9dyr91r!cȓCȑ'#O#G2F<9dyr91r!cO{'IENDB`move=1000;blend=1000;3FF1""4w  j_ZhjZԿZK/j_ԿKR֥/ZZj_Z!B"""DA#$$B fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU" "I$@I$ ""I I I$I$D!B $I$""""!BI$I""!I$I$I$B" $I$BADI$"HI$I"" I$I$"!B I$I$DDDB!AA$I!BAI$I$I!DDI$I$I$DDAI$I$I$ubinding site for residue na a 444ac4GJ1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSA^6^  UUUUUUUꪪUWUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU  ee ԿET*(ET!QTGB?KK𨪇kRj_K֥T?ZBjuQj_RRC#ECB?֥K/ZKKZZԵ/K֥ZԿԿ-j_KR/KZZKZRԿjZԿZZ֥DD@@AAA""?NWWfW# 3UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???zr$??QY@VP@?V?V?V??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2PNG  IHDRcIDATx{?oU1d 7AA%j0(8+2!q]j$dsΉ?sDƘc9>QEP#EGT`ffzU= 3]=3yR_~{e^+C0>ՏP5#ߑ-+hSAHwIY+ǡzՇD*Jo#WIsd0& &~4ՏOi>Rzx2w ş2 T?i x/D/6ݧqģ( 'E;sRxDrr TU# X#"UL%Hlzg A`&'I}ɃE CQTGsRxEE!/"/"("蟀͙!4$@ծ]Lc&410t(Dx2Bs`@ز[( '[rVxdx&W_?¯Q@ 4HLib:S)=I* e$H$c4~sģ*s,e7NU3IbvaTTEA]dn068yjuj T UQ-)*HH&&ҪLCFEc * tՆΐӟYD; 0#UQ0uӳ̰3™Z0LHe<@k5)!Nb5g9}ch(npfDB ')I4ޓ;3)^H{VPag][a<.5HRzrARJH|=.@E#)d^;K$i"DH.jXkǏ =')s[fW ]+ 1jo5INs$ŨhNr3͕e\kRzE+>R<ǁm!8ʼn Z<Rxx+:!{x8(RN9yxhyx L/UΠǐp8QeSOհW$\]Wm*A³p7sua&v[ T WvO@;|\Rx~]R\붹yx}! /g^yɏ~l}Vr<쳧ܗ?m.0jŋ-[r~Ŋsݾ|YuYPP%7{n_|ߦ-[ƪUwǏ="͊(*Q1iaIQTe|wXf ӦMcٲe/]}k.v~`I"nNtf:z$0u|>ٴNTU͌lݺ7|]?۶ .?抋'\TaEĺDv/I y34\MgK3{>MMM2{;vPYYٳO}sMgՓx[7.O 0/?1fNGgڏp Ρ㝍WRt2.=KfֲѽA]]XF^~S/T`Bwt7"Z>9EE6l[o;NTUP(TF4G,؉Clˋ]TՀ(B b]}]y\?Y';N66P.s-%E$q{W3ĺiimH7?~O}&M[o} A"#Hp].'ZBxB`#Zop 7}+Vmysc}`;H }8qOEҵ_(X)XuW߉f'Mq:놜q s?DYquz,fΜ9<#L0R{WJ(#(*zr/_N0d̜9)SPUUEII 2|bK0ιq.0u07^sWA;H$1(&Ggo+R(2IfLAk R}ݦ'RSSի w/q.vc0BʋS|˧Ҥ]CIGDZM L)lQꓧm{X8XXD2J"uM8W]~dj@bFNwdb4ym.he}zA lg?FѤu{ %9#t cHnLq^JP<{6}-ov`y+vHhBwEz.Jams_5-SQT=@y~{^߁iW=TPh^ɹp\:iw3M{I{p?Z|{G{C j! i=P&qK@ _~}Z&/hvf4g6_V#A*l޹&`, D8Z1l;(4)%T,JG @0t2 B?WӿCd^;8 Jp i7R/VccdiɁ `phk2I$ԉ&{y+JbOM8CVVq70kV;~]3i.\?98P]XK<0:_JG\UC|).ijL 9~S*L(B4Z[[yojsaMg1:{1\>x]js!y蠽9s/ŶB-JUw`8}8z(;wdƍTVVR__[n&jkk+>ۄ,;&"z |㼹ʡ\?cƌ 6D&oܝW qYE$ˎ +CS}hOs+V'`R(؃Z. oK0L"b|Sٵk֭˜l{ж>7 q)D22;52s5цN_/ ΏĸX;Sc kZ,4Պr~PUo};w~wG}ƥðI ϴjtö68`}pǎM՟E7q0M+"";-{w3M4G}yPv8:֒S2_yõbևơp\OU@H!BIwy|Jp<##ӌ][{-uuu\s5,YO<#’Wr _Waҥ#1ēײh"/_Nm_֮'VUV1}t*++puճ6H$Xl;T_Ax2^W=H6nƍ !҉{xrīn"lT\(x~USgG+xrHss38SVW/eOill$۵% E((BAM'Dp}Hi>O9~ +} /y#OinnWV^ EEUF0'saJJJX3[+'T'x-jRz ]OHň'#n< lf1̎mu4TMo[nck;1 DS$Q WׁƮ.nn.~ek\od~/Ӱc'\y\B=@ 裏ʝ;wʪz4_BnܸQ._\L*P.Cbן!LJc5k_VOuuurӦMޓeղBJe(v|3DK& rɢŗrJZZZ8q"?1fg!Ι| O<6_$Xe20H10;:x:J<F8}i KyؘLR3 aYE2J&msٶ+}Aa-B}d*e͈OHIQc~_КJ oS a>OJOs]M,^lSyT0, /립(_t刍rb\0g0=X8ňrsq=,Fl & 9ƕ׍Ͱ`YKU:1)>-*)15&dmpZ8_,[ExYa\@\9l[.א`)=[nO?C#'s[' 0u.\,X\g%g' $«{D^V ֬BEUU {6˒ G0(p~=z W o 3*X!߄Ϻp-r襳 F(Ws6o`N$/}CR-[@\j>^ufogVY18xl+/r٪O?MW=?D.sVn,3=%a*L ٙf+Ha !0R( ͫ}e̎0ϟy @UUj%JK:``n2M@Q4+"ՅXۏUP9̚yEe4>!C;4Snl:aG?mEbF7a 5ZjIENDB`move=1000;blend=1000;3FF1""4w  j_ZhjZԿZK/j_ԿKR֥/ZZj_Z!B"""DA#$$B fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU" "I$@I$ ""I I I$I$D!B $I$""""!BI$I""!I$I$I$B" $I$BADI$"HI$I"" I$I$"!B I$I$DDDB!AA$I!BAI$I$I!DDI$I$I$DDAI$I$I$ubinding site for residue na a 444ac4GJ1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSA^6^  ꪪ*  ee Կ֍jRRԵ/֥R" T(CT:"֢5֏Kj_j_֢?Zu]DhZ֨PԵ֥RRRZ/֥ԿRZZ֥Kj_/֥RRkR/j_Z///KZRRԿ"" """DGNW#=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ȭ$??G9O`f"SO@?`C?`C?`C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3+BPNG  IHDRc IDATxw`zffVY%Ybz@R \#Hr I.=R%$@ۘbrQջmfhWJL73<)$>oBôDc)c(+w~,5~K>s R"DJҹlĄ/+cKH4ĴJ *fN?Hۦu)- BCmJF6h +@T̖ß@NVz0 `PNK )))-ίLz"0#ϙȽ܍k.g]a‘}t6;Z/Hߛczx=~}'*ESWNo;M5M;c1LdׁGeRVTCKaw)ǺahaZ1ʊjhNdL H(:y_bH ]-e' PK!fU.qg *EcX8B~NI\7SՂ1+B$" ә_ T^Ç"ak3O>WBA4mqҠ֑RR:At,+6O^~f߃bLт6}dg p"-]Y)-\KBq鋰͡#o&WRP.j'nJuksǷhjt%{ 39 y0^˥g|&%U %]-mZil݋4^F@Ae]amNɚd$v^J@J! !c&?EV ]-)-fFqHgżLM3$mM!7RN\z"L3«HBy}M:~H)IaKiI,ۜB`7@dw/@~_QJڹ z纷:#x w=Ja5FnV!";ztCm[4'+GNH4t%aY14"anض&4WO5B=|9I;ށvrEi P|[.pd`6^}M(O}s-qBNv1eE5膇PC$6m]#<,B~tMYr/p Ç@(IMS;49wJm&˟3dE;ɺ qϠ [tծ%;L~Ϗޢ>c] A@mjzM`h:^5cդil}H* ѱQ$rFƍ~6C~+?} N$>z[{ **$|<n`&khphon9v&%(. 4"]Gǰ0t/k;S9Mc Vw3/tw;N}rEhpYx :^mlIJ-BA KTF1*z\(V ]GhckDd3Çmtf *PYnpjVՒ!w#Ė&mSאly/+6%Zw*M304r|%8BCtД=%J=;:t݃edܿeA@anvͻ3NYQ29lMWx'y-DJ˶B]{xaZ1B^Z?8<W-:q1HUq&iDWخeWJlicZѡ".{ىލXPMDoؑ` J qi♀ZXWN3dԍvm%- DA9GR$:Ȃ5ضEan`ma1lTuRAQyj0qɶ3 TK%QRJZ;ҋ$cZ$ }@tAJ,;nHi@0%EmYI Rj*㾧v,rkPj,ӝ,¶f1z9Cv,.yx uǵv ea1,zOx^1grJ (/E~v ?}si^:MG.c 1T/0d~*@B#oLs̙?j ?領 )-kװ}J`^JKVTCQ^9_M3~` H, ?\M~N)UO i:?S)ʫ ?!1-֙=łk)r ώ87/J ۇ^1S{xHc^4Mg ԍe[x=~,:Ww=t FiOc= g0ҢgPmb|dpl;]u/U/ԶPO^qwMIcSC9J{w#f`K/Ⱥ)ʯ=u5L#WRVTCv`Y=G0 /~_6Y\Nmu!h Sw<0ADtP48 P[Jq^%!fFo[A t0% 3tKv4`Q3J<,[p{F:k%?@h,Dyq͘V2Q,M[fs1=q׬¶-̝C7, !Ż[x~\8 e#jZ;l3?n }>rb.[*԰xN[x~+mݤ⛝1wrXŴbw5~l_cpe5XRm#;E8~+ٷ| ǪXg)m,´13B4!?gn00LIaӯD6BXhB`Ke[;>Xs Eyry_xt/E ETi%g`yj\~՛bvn ȣ!axYQ,+iFmv?H4́ $ ͚--R` {w/2m4>2Ņn Bw_XXQ9qA0Gv @.9Y9YؖEjkkΦ\ xQl\(+DzTpYqFl~r+()t:& t]';#c|6ЉbSIh`Ξt6s*[=WP3` w+[G{E/c&0tMwIA%^)ۺ)-v)$+g͚5wyS祗^}@y,BJ ٬%tfZQ ţC^ipeg"mI$21ʓHIHyW춊^0gصk555̜9]1tٻΆeUW]E]k5FSUO:'㡼,uMg`MB[g=/ᤊ[ 'yPC*jyunȩSRTTD8淿uYWJ:798{[n@A ƾ2a}pk{,&f^Bv$Ft}K1sLJKK>}:۷ogΝhFyy9s!//\ѣTTT͝BrKe 6ruŝM/);&)wqYu9Aw<68icw;:y8UM&2ŬsA<8ÇlϺYUYs [|MhXz0;b<]L/˜,]l(+P)Y}pغu+n` ???ϹO}6l೟,ׯV [hN݆D7HvVy)Cr[Էq; 1>Ɵ_'f TPp/h?l:f@:/qa'w_<466:O<˖-#q$}?x۱Rڊz$`1L+i (G"hkx ;,2Y0s2 gn] ˶0][Ük+?W|^`Ê+Q7OQin;@Y6/[h-[gz!֮]˺u7$D<nYvcҵewo/2gy;vSe1zC73r$V(>J )+eifÊ+xw%^ux6gP6/ȋ/Rgy&+W /䩧Wv~ ʈ<?oa~dT6Q3=.ȶ-Pun$^OJH(9%2£VIa>V ^i~U`p4Y}¹SvS]Φ0eZa5 ig)p)ΆCܹsD|WJAA~;/2֥? 0Ƣc GDlg<մ9 X ~Bu/V7`∉Fm;a&k)D$MCm֭[Yzu6 ;vtZ5iEՎ*:q._@$" 1 U2ML;i :zY}躇k{x /mfqߓL]$~#C|˙aɼ5 ˯ޜvJ E!ewy'7xcA)]Y{7:lyիy⋓_ 9 w}u]3#XVLjx8~;UeG=g4QaZ)-%7Xė?krrr룧˶Ec#!4 5#D}t!''fqgmam 6֮Qe'#Ht`шǍ7u]ǦMnn-"p,v$Ї,]X/b?õ ܟs:>c8kx|vՁӅ@GC#˗=Gihyh,̍tT=vaOO|<~ %8ʿ0tcz;G00Û:~ 0zbشX躇P(Eu^*P>O |*u5 b̛77I^)H2MLV1~zʊjUmhlR[Il\J *@C#&Zl8kuh4D(D$%)g8gb4-P>{zTy;m'&sFL_Fj{s=^Km+**xӽ"jVa6RZ0|yI2EyL,ۤ emSU@:ܴ  hͼ;JXؾ)e9\ucԺwTI/>`waK9>oMӓ999Wbxlۢor22e=8.XvN3n b%*X3옦S2SQQ:O\~pojXNZNؒ}N2!ayxp/ҶjΠVpXǧ\0UGUl& RmS=a;k/ /g|&>z4=4c_%C_tHj|; x""rv6]ww}wڂYO[w#G9JgQ:z1|)!c!7۶hjHk [S,k*/{"fQ)/G/ᣭ>矹]a&?(?Go}gt? 7oh|gc@(2@K555)Ͽ 6$dC$ b&=m<がڦf ABQ~ ׇF[fʼJ))"??^ruf`pŴYt___~~>۷ 939S3[Q^9O8:[8=W׮U?ifj No; @ GSLRJ OC|^ZTId㗙?s!?G9 Ë{XPXh^rXByMo y<фeYf IDATۍᩧ:?s^C,%Ksm掃]gyn z<^z֎z;蠱eGlFțϥ^ʊ|ロ꽉sZl$]^LہxGnW^yeLan *3G" ]MSм -;ex;c[["y#D4wdZQ dgӄߛe.{ar-lx:P[⬞vis7zAϿ qBJIgo˨c8p<w^曓Ʊ/&[97Cr8Y!O!ae:8&+e 8ue(&)=1:U"j/Rv"MWS&1g8fW/%ϣl>G=[o[ouKKk.#}l}Q:7Xn<6t8-'üUec^_߼4_VN{;&)YoK7~SN9e9G*[0Ӊ1V91%hFY1pwogQrE3LzS"8>Q%YwTp01l²RO_ųUZsth,@8a{%8ayV{U 7,UQfNop´c,蚁{'7Yd쌛T t0Te[ضmjW唕ն-bf ˯m)6!8CI%G7zS*RwI 9 B O<?bfjֲLZķNv^-mƗG%88L4 %fLyQt}u}A ”"Ptd+ӐнAQs= i*߅So'r)?g?l&&j{U pL0K(֭[g?2US T?t`KK ߀p\ٸjz 83p,W--w;|i'>r3C8Li=?׫iCWWmmmo.z:-S#E$"Ygfв}RGcL9j nB:cY1"A Oustqe)QhjS>C& >_Fى|X}/{,%^SAZS?ŃOϰOOHDmbڻ (g<9fƃ .C9yceXbF[]+5?md6Ud}wbVL%cIr=-UK/wOgRh+iQ ;6:3{hlG]kfi?c,?gfƒI!3}= @i#kF~N)B[|>RJ͜S/ t̆B`$mǝ͉/h8`l:*OyL֜pO8ǝ=n?u ֕nĂY5 1tڢf$HԄ\g: q#Đ3>ΩZsEo)>}-[:9;V"/qڊ+8Fww[6&-eY"}^@p Qǟ7s.Gm)"!1&hnjS9y٥=W0]"`VbyH&*8GK! G) r 4M9Fv  ))KPi̩KN!d_6</A=l>- IbmDƽyq.eT*!4Hi&A~k_u YynkW=^q =Gog`!44Ms>3!TBp.B=w ACHaՊ]8e=he-'\76!1k4IG0IzG2* f8FZ;?м[6麚e#4졻 7ܐPE]p+2H C7Wx\wI]#cmdDK\vK8Gb&`nkꫯСC<\fi-/;"N[?"?oèyx<>,52 k\e0l:U:&z𒛛GIQ %zJn.Kk*&@Fy'ܝֱ9VǗKftyl<)ἆ5*g5IUf@Ra"Rj`v`6`6~u5PRPw".HftYE=275Q\&>ǤS1(e5DBn~*I4$\S #oQZZJ0M0dpp6#??ؤ.:qT N_u5BQg}^6{뷱ב'3p Y wġ5яV YQxe[N@J&ǘ+?GNG{}?Ug}_ilI!1yJBh7J:v T&}#[^DR1XH1FCEq F3z3%Ud?1֏?%g~~`X@{wyHۦ*#~TشZ)9Dw__6N6$Wh*p)  ߪ2b#DL=7E8< ݃:&bQ,CƲ-.p#f|¶mʊjɞÓc8sL;gG~ bZQE9fMkEA崹=PXU"BDTDzL&-L~%-/+62eVX,UztjXX}q(S)!$'Dw7r,U%qcW?ׄ)1|Ȥ&ŘV aknda\u1t)]w ,es#_vUc01+`J w(ZhCnm'J!4y8\A$y;c %@m] T&Np*MGEdRp@q 7I=HmyO~GtMG7<躁.-PgYL2^r9=`O=q-Ca<|(hw'݉p(?><0y꒏l:'-_]xʫ8uE*7cb$F'oKC~du绐 ²ͤy%NU<=gЊ~FA)%ҶS֢Jg:! Ox\mW[: U;V;;sϥs,ʳ>[^%EĀix_𑋿>1ψzm'&f3GE Ro YZTiO$G JI]ws)Bz!`'U_r\[A?N9SXv-htD aY6'^_6m%cQbbV pKu!hTZ<*6;i+'XIB34!NnޱCGdo6?c0qA-fxAp* w0cz5&||CݴL@լRBOt^@hH%MJ̌5# vlC-GTتs+44aϡ@җز1F׬ƶ-^,U!qlv= фH=<V.vҧ4MSB T+(#F۶Yt? 799cC;e78&He g0K"BrMwg@B,Tx]@ï+pƀd sNr{]3ՑѸ3WI]_(&8qf-_yq7ԇv.Y肩Pq&ʋsVxǒΉ*}lߡZSpjڼI}\!}.O<͖iKˏKHqFL%$%BJc8*xI|SV^EN4FK@،LyL/rMcaH8O\>>)Ukg C$ IBv"wNOKa:#tt7aKKeLM8o%c3׆WOE$6[^R6n[BH;w"IN8Z9y6%v ;Ԓm9jhhG"X=a=#4{᭺x+5Lm<-"';)UIOIAm]M'/ \XJ(iybS,9>wK"̽YOi }h.9EږrN8hJ ]ʅ/)kſTш£OWE--d׃Mo$,S *L'8u29lK+d%Y n8}ms<6E[J{J&9oS`'مڻtVNdCE xjC[4ԹmQ:֚;f^UlB xnR|4[\sں8 Lzm'p|e 灔v k m2zYX:鰞U-pvZSb\f݊e.߀wpJ4i[v^rh&nyp mmXlN2T kKilzaQrcY1Z@d^u*0|ru8/Ͷүƛ)ڻwݑA8N\|_6 yj]IY&1s$ypXv 7HRs@5im<4[qʊ+xY w @Es)'-7Dֻk)>cӊ[SSja4;&ݙi-ϛOMj> @=<7PiHm9ٺ;q'vT^]km,[S']:q"&Jlhrwʒv%s()qkg â9'5Ґ>=wGB_}"qch>O˴=(+:ZGhj-;iO2;?mK'ymT;c[AKĥ'cȸ 4[4;A}BSĉn@ύwumc&m2b>gx^˹']?kNڻ" d<^՘)zSX&HM3*2feBD&-N[J 'b\TٳRL+DCL+Əe>r-Lb[sfE&NB>N^v)13J SSq;&4LHqA%SJr| ~_`ZQ*fض[g!V̅ewO{*lh r,1]?KJ~h,):w>nQ̰|&UBB3[ 3v!2x{EAW6qh y-9~El$'jp׉[_W۹CAX/GbH$> o8N}RBZ"~ƬE?JRJ$od&Jۇƶl+ݛ"K &푌'j  s[H$Rͷg{ g(Lny!iCwh|c|ͣ҈!?$xEɬ) jgۙ;c~Q`B퇣 ʰO]Ѩ?v$.`$Jk]NrW ͩj=ˆJ3%?tQyr<Ĺ̄GJʛKlb'RƸ:JpKx{XX]RbqC#tX+TC (U&d/>tߣ8i#}-Ú+JfM|"I>=a贚;Сn Mޠyp4ҋo<Ą1QDb!@soUhv,`OÍ]V\K1X@ Q3-KfhD 2M2`~ !NOcga&ܟ̇,a1V\tIDATYqS$j.kCPzڄ,qDVK̊EcP>q% {]ټbQ(vݤ,BHBg& s˓ ɶ]C`ϼsՏ KIYLNjáqz|I'8C}n˄y'zvRSOe `'%we!sisÕUC ` &m M7Фƙ> ә5 NK#zi&i3&4T 77y)m|Ν˄e`"y'T0o9td ?~ W W H쬂&+:QB1O ;%]}-})$L8Ld $ZA=I :^݃8$׶'ƥV v2j OkV,<mmI 䁔b͂ flkxզRZD#lvIENDB`move=1000;blend=1000;3FF1""4w  j_ZhjZԿZK/j_ԿKR֥/ZZj_Z!B"""DA#$$B fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU" "I$@I$ ""I I I$I$D!B $I$""""!BI$I""!I$I$I$B" $I$BADI$"HI$I"" I$I$"!B I$I$DDDB!AA$I!BAI$I$I!DDI$I$I$DDAI$I$I$ubinding site for residue na a 444ac4GJ1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFS+A^6^  UUUUUUUUU&UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP  ee Կ֍jRRԵ/ /Z֡PjUDBFEZԿԿD¢BTEDB*(QWujKZj_/ZZ//kRj_ZK/jZԿZ֥Rj_Z//Z/R֥RRRԵ//K"" DDNWW WWfW#! q=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??LG}N@GP@?@7O?@7O?@7O??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4-PNG  IHDRcIDATxypy?SKd66qAb dfz n7RfN;e\MHi0@p  Keɒ,+{w+w}g~] $ '|EC(rEV%IgY$!$!$ 0M01M60M#뵁nhЌ4td*Aw&&IH$#!@6  -/M71Mti6q7mu Cl%ϲ߄,)M_d3~uLkds !y_C!pqEkPx1ŢykQE\[4pS}Mw_& @S{ #\PUY1ݮ-[Z ŏW8}g\y;7Ƒ[IYBLi8;=@Vޫ2e4M]K_o+$nc7za"V.%G ӮkEahzu%gr{$4#=aR(6S4=MLq0mQͥLPlxň>Zsi4NHQC1-4<U   yZ*xe*ʢUC1%č+ox(V! ZCrL4 **bmmZlT%zYVPd{\+} H9F=ȵ$oxC'!ПIv/$a=^>[Y|ǃ#ʊqFc[-beGS&=--,.b&,q׺m~X4p>De L_EPl7~,@V7U1Lk5毑E@ XMb34 6  ;ݗ=42c<~63?{;Y"%4cF;~[:zcφG@i0m<ɯmx!e@x>鷩b| ^׬[|M0Xxf!B9 _7@n;DoP?tw !Pdɗ@<䗯|/n;N{i:ϟ\YdY˟'E2 -){ 4M[9"j>* Ni4=y/[gD:OiXX5e*"8P%F01Ѵr~>.N'4N"+kM,RAå-/%-g}H$YXc2CX|)i>|{o3q!(Y$IJ~-8}4wۜE$LĊ-Y4i/ߦ- 'KJ<" h#K2RVN]]fW-K6RgXˣz}I,+'zsmFY\/,VMy8*j=S]&#~2<$ȵ泿{t'W9V:Z8hB;G>|YjkK\qTTTpWSWWW_#Y-I )M&GSv.x}9sYQ.HmU-Ռ,˿-wX6fϚG,RV_VZʕ+_/̚XVFSpz'{SOys5DaP]>IT1iTƏćy-fM]ΔI38Ձ }AP455믣iwy'7t/;nv:C7JNbYM&#|: ;.4"I.IIxZovec)EmD#hF2Duda^[2$^VM%)'NJ';to)N¡`&ۿg,YBgg'u"vHI,"kW%)zGui9DkgUW$>7͹mrX4L]HYBӓ>{c't r&A:xʄiv+++y衇Mn0 !d֑`C[X-@Ӓ$S^tilWʁزe `AOT<-@ Y&\?ٽ]Ǒ$Y= VȇiGk_4yZŒ|0ٴi &I7C^UBY=tzt8g,]p=HH8J8!JKOOd/aB릎i8ˮpģM //ܹ+V_ފsN}%ɵ^;kA쒄$))܇r#9 Lai;w^{UVzꩼgv|T:jrͯ(7]~w|{ٳÇu NJNy߳פDo.z]tuѝ,E|0+~;[n4MV^=#fh=>=o],FAUa:cV§b ʇ@<yy&O@ ț@<y' oM 7x&O@ ț@<y' oM 7x&O@ ț@<y' oM 7x&O@ țs`IENDB`move=1000;blend=1000;3FF1""4w  j_ZhjZԿZK/j_ԿKR֥/ZZj_Z!B"""DA#$$B fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU" "I$@I$ ""I I I$I$D!B $I$""""!BI$I""!I$I$I$B" $I$BADI$"HI$I"" I$I$"!B I$I$DDDB!AA$I!BAI$I$I!DDI$I$I$DDAI$I$I$ubinding site for residue na a 444ac4GJ1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSA^6^  UUUUUTU  ee Կ֍jRRԵ/֥R*PP꺨CZ֏Z?/Z֍ju**ZBR֥ZK֥֥KKjZԿZ֥RKj_j_Z/֥ԿZ֥KK֥KԿj_ԿԿԿ-j_KKR"" DD@ NW#=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???XP$??MO$nKRpO@?E?E?E??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5,PNG  IHDRc IDATxyս?z}aeQ6pADcpI&Ql 5ɍFx7$FoqCEEgf:{XrStOUS;#E*!5Mʴqy &4mj@)ź-/0~,z׀RH%y?ĭo؀)EHig: K,;n/+.g@%,W]9 `H HPJ"DJCn A#̿4R!BerC-mManU26M(@Pk>!4h"moR}O8[@#z{&-W<֣$)$ 5Glh]C8?12"O[ ӋSB)ʼn֣h8P0JvM WE4[7 <$lbXRIeot/p؞O= ֛h@h}\󔒎lJ ESaPqCg=[:BxpIia!THm?Gvr4qxGM:' Y9xlw6.3'.1% @o}JiXB%+xQ.SwSW@)I4[I618 )Iezn+"e2nCnhSCJm y"VY#;~ ]B!PH$BhHCyL)4gX^cGG ;92yu?_S؃+Gvӫ-;A)ő"nc{VsI4d+JBF2gg*R)|woLx 8ּ $[6e}O%8ii ; oэ.<{eo3yW)#[ B4 YշY~q<h ۇC삂 ͖NDRz7/!3&W\21<2_|bG݇I_KL=N<(ʼnF IF%3~l #8]9䱤gmJn2ФKUv{+8ZE۳ 4B P%5glN_ FG,d eM3JP"}s.+cv#g k+=d@Í\,inZu&q#ٻKe Czi)uDrhPJY`19 ,iacScБBR%8`Bfln=r )I8O7$dfeP !\ dظ'ufEe9hHUeH6,p T6R4UbsJI#9T$ i|\٧,[94gaG3sqqrw|t#1W~0y<nK0DZ,?_gO){bYJS tϵGtt=@PЫ<Ҋے.LH m 7p6Ԥ1uu5hmK$bCٳK!, 9r95f5F >] G\sЙa%3S(mc羏7l6K/W^i)Lq1G[vJHQ Xq;sz a6#M`Ժ+4s̒v4奨2h89}{ 5M (FkÊsG\Taѝoц^A 3 Yc@1Wrw;?*yZێ[Mc?g"ҁ4KE|co9q%ʹ l?i;&&cÃ"eom37^qwFmqCgqvۄeUU zâa8ڴ!4O]Od䈐i{KPϞ}[:̇6e)%]Vء1vLv7lbͬ"ly!|X*L›˳G[ފfquD.U gYk\t!n-;u\*÷ϋ4߸H6ZQV 5Cfil2֬r¤ĩ[ ',b'.C¥NciKQ7 8eF]DǛřDŽ笠p!Օ%WOelfZx9spTCHm76N͝ _4-1R 'pID(~fJa3]t8V|J݁[Jq;ˊzѣ 0u?`o4γW.,׷Ќxd#4`N##~쨃f{<$x"ާ"vuu&)$[QJaH'/q8Y1"mKy?憧ǪہPNSŖdS)h$29>^B1Ι5~mɃ'\-哷ǭ;mb9c.1K"SFGI-)/Ǝv&h~scji9i >ݽ6:l-C0)jCSp,w M Ӥ`G~/?Ss&0A f}Y#/5jJpzyQ7w!=]9(ƅCXsOw=8Ӵ"ɮ)MߣT? pçJ)^x7o^-GBo=f&};^0.-$(4I+ۚ &=*? 7!F<[j% Kz.K:y<^_Go}9<&P^xw%/ۮg'2#/BLa˝܋C)MimPݮnJ"U8o2&7h>G cςy%%Rf.|+jٚڄvCgԠ?aj&3~FFTJNg89k;n9 QTXuQ;7t}%?V{fo( _{ :_G7֦;R 3Q-RUџJCm egQC/"n-qΰYMq~c7 )`ۑJ"2},u_r wkX\5`ˮwi9HA;[9rCtͩgϞiS֠5C, B[!t%WZ%ee:30ΧL=j|K9[;q'ٰpayѿܜV9ltgZdLI^z#J!6X= #!Hi&J"ӯfg&Els$}|||ibw1>z\.7ˮ/?[oMLDk3ĂV;-7:Lw31O;?D`IY_&}v- ϓϓדcp8aСwohȿ}њ"±(1(OD38?!I=uփW5WUzk2Ttw)x,.[ϠMn:i&%fo`mT;(-d;aK`/iѣ466㏇M*b_ |%ےwtI }FB2T;MѤ3Xϔ .ǺI{z!RHq(օ&|pj .~4!,"ylphY9`vDvQ 1]g[|:yLhu2v6 ug4NQa[v+ѫiI@~iJEuA2'QP"\-ux<>M1OqԛB"2k{l-V2|Y-4)s:ku!B8 ;?|M7]\#uV Ek(*A" Kz2b>*KscH-/EqH殁5MfltYqH`̜ꛤ"٥sBX0CrOj?H)OEáϝ}+|_s&@8y :@n)u 䖫E)-2ESoD9޼7?ԉDŽ 4RCh-i@VXWl?&4D 7KeŽLg))o%[@ۋ7P7sUWZ'&ivZێ㶳OIC`/pӕ?\. +:@w暮),9$}¦a3-[+:!%EOHjѓ惔vMJ)fOZԲ s I|_ȉKhV.aȥqin4p1BQ`D[u> %aV.H$k$  bƤًm_,C^TwSNMbϰ:'BlJث$[ ;K\gRyJffZOEУ`~wOve=aKxrJo0 n:t]DŅZámsA32phi/C8pdW\V8xt7-F0(`3fQJRTPVFB0"*z;}^54OYs=a q?MF,5IehOʔ*ҙ7 cX?fܸn7Δ=r;) O&U nWǮ_S__;Dwf~G'Jh 4- =1px=eE=ym?>/ffse|nhmoJ]Pe!Ѧ}YxKf 4뷾d`45zC%&2`(sj>yJ||{%mz|󛦫ǽ Co_ֽqi4ق8:ig?g_&./hGɓ'S[[l6D"Ϡfg2"P^Kwafre|>+ ),ƽ4%w-GuYи):Vf4i/9܍ilޟ_+%zmS@9t;Jnݺ.u|lm]BpXy[Jɵ,X/~a:VU!pG,7pwy'cƌe=o\o[ 6%@7ڥQ_R3,o^WUzLe˖!Dq4B-eϼyx饗"N{` yLt]>UF\?%2Ϭn<˵>Wg润&z)^9&q̙3C~ӟMB8ˎ;1A锕%8.eF|F>q!4'kwEΧ~J]]\rIשe( (v|իYb+W!9yر<<$Gvr@ٓO]1Z:jgtNm N#ql| }F+lU2zfar~ p,[{ܹTX/fƌ SZ\RXD# nަXP䕨2UTP CvY%* KK_vy̢`|ă`Wf?km<;s&pB.\tFgM|=,(=-`vYFBdpin"u7bUW|G]6(\ps}CS;N"`%)Mhp2K>=]Df zP߉rnR<_Fgܹjʕ P_k֘֬ }+7J1']s= 0Y]p"u_ILjUU1@*Ͷ~F PK.U^Oy K. }E1 {o%Tv0?OUGIE=𸼸\nT2@ N[G 'ۛ] :lMj<݅|o}[nί $ t%i$yt|x=UCUu˔Re%UGIQR RIuC˗/vZ~iVX\% ?KՕq<蒐)Z1AYifm[1aB r?qNCCwq廨7?…`YhY]9') 4P (u瞕A#ḠKNyGYx1`Zg̸B^#-[RVܓHj-G(+<ge }^—|Ξ8UUU,Z4^;x ·W__eǿ8]TW &/F!Cgw}y',lt&N'l׿<@wCٹve9^[L‚co;vkwSX֮Ĺ5n„ \.ZZZzq+6 Wy3maba-H9kɳo_3{tilycb >˕W^_{h2”6WĪf!4& G`ثV(Y;ݻ`0CM?]}/^̢Eb{\bawb]pBbfjeTgU'3,&ϢEp6?TI?4~ Rs3Ӂu e|qi_D] đ]FQAyRQgqC?aHAЁ*?z6bL@Yq/2'3~KGOZu{]YI0gQkk \׭W &{3roK^}зjy@rjW:KɓC%E:wL<3ϋoӿzdhywpL0`0 >|Pm{ˣh#G@ aLn yya"T{d4y҉r!mJN?r!mȓCȑ'#Oi#GF<9yrH96r!mȓCȑ'#Oi#GF<9yrH96r!mȓCȑ'#Oi#GF<9yrH96r!mȓCȑ'#Oi#GF<9yrH L٫IENDB`move=1000;blend=1000;3FF1""4w  j_ZhjZԿZK/j_ԿKR֥/ZZj_Z!B"""DA#$$B fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU" "I$@I$ ""I I I$I$D!B $I$""""!BI$I""!I$I$I$B" $I$BADI$"HI$I"" I$I$"!B I$I$DDDB!AA$I!BAI$I$I!DDI$I$I$DDAI$I$I$ubinding site for residue na a 444ac4GJ1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSA^6^  UUUUUUUUUUU_꪿UU_UUUUUUEWꪪ  ee Կ֍jRRԵ/֥R*P**UDUDBTQ RZZQQѭT:?_T?T(C B-j_Կj_j_ԿԿ֥Kj_/Կ֥֥kRj_ZKj_ԿԿjZԿKZ֥KKKR֥ԿԿ/""DD"NWcWfW#GUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ǝ$??F1alJ@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6B2PNG  IHDRc IDATxw|\ՕǿLF]&wɖqb eI ȆH6AlMI.lӖNcl ظwY-KVe4㕙f${7s;#:$!>tӲdn! Nk>u%m@%$QFdDAB%DAB%^ǁn"@U,"@Ԙ}03[hk%k/E Gbes6R@D@3q*AEO/*=4RM]cEvBj4USQUUSU|gL4$QB$MzΖ sd/$AvE5I4 U@A|ٳ6G@$dɁ(}ˏ5Q^sڳ46Uuw#jƳYb8ʇ{c;'xN;,;ΒSԗcwKBlь!KSgԑ۾N0`s@zK*No Uuginc/k,@TRJ}S% eu\igGVP B='^>*7u@LV-2A5TF d aXJ9*ƍw{xy< MW?#NB\5l}֞#k0zdi&ƻFkk<USU:myT%5ӲȂ;}|nYXI Zjk bڎPTzĞkA74`g8W7"7|_m4c31jT2C@~r؈Tuz޼5<1d< q N,9ٶ繘X6F4͘=RQA5Yϰt![t䘕k*qE ݺ{3r P1{eǩ9Kcs5A "=.(A>볺 %T9g;2v%$f{0xMl ٸ>&F$&JlSvi*u͕1?QRP5+ @VfDU@@h T~RΖ\U5 eܲA[c0Lf%dў1t ѻ$Ȓ~hJƯ_h+%VQ :(ƪbǺ%_3': I E UJVf^L*. 3c8dkHbZk# 4qxL(tF-qNq"˱y46 np[5HB|j誢()c/*s.,ޏCv0$ɂQyA []~*- J_XeC neWф (ZtL{YԅK\!Do<6xAkknFYg<:mgˏE,%)6{=~+~󷠨^Gtt?{]Kp8܈š0jFLšE#- .XY͕)̈V/JThx&U"Q=ycc{f;fxɞt$Ɂ(J4 癷bC.Nvn-^{ @筝C=Y2H[^0;st D{cc}>wo{ee $9dEw@AA?of'uNs(vF$Uͩ$Enc}۷yoʕw},_>vw g`NJ/ -5NXbhaoP l%;?19x!3#񽏙qmFx馛(**⣏>_W|4~,;QTן f(ʈHMC'\kۺ'c|CUc9/=#/nֵ^z{iӦui<7ٴiW_ Irr`YsV՜ =U-Qz" G!t6?o͉'8x`)WXud(sp^Z0p, EQL'uYDj+xғ3*^j/}Oc=ʇ~ح˲2(<ɔ18vӈ SMZf3t]CÌ0cV.5bG=69,]KhICN/u}(x|u׿Xhp,?}߳cڭx-ˀʎzme˶AQ3OYYvAƾpb+*Zp*;d'.G3/?=Ƕ8 R =E{Xw:8׸&'^~k69_Ė 8$'@}_(#/9?٫" #ÍCvpHIIjo=ss`;,-H ̘1`)a7.tL;YvJH.2᣻Pv|We 3 ^wpz[GE$/5L3AyyBQXXgoذ2>ӮOd4)a|AdW6+syC!O7'{5`44WjBkcP E_/ɢ&=T ewPXϞ/wyQ [_ ص߭p.f0E;Sza"Œu\ 6[< '$IFd3*@G3ČA5}f8e"r0ʋOCFi8sOQZY`Ƭ:ȝĸ!FE.M,裏i&fƴw>n@AY)zAfQ@DT {/{졠Ks FE#2N+&c@.g<0{նrGgm!Ιowy m`ɒ?w+݂ǝdU^FeX!ۉM8y uyc@GQ.=SzͱóM:(9s&pmkhhh8u?_刷7"bޔW>kLpW{#+3^q|*?!i%m4dpZL yز~]22} {+%V+#owZֻ%>GvHwBAaiƟ^m]PSUp7nL9!$ ѕ^J.gi<=A㡡?L$d[pUH7n4UAQ=.^٠x[' EQ MD3F7覺u3bSF`%{m,] m(=K=p s%qݵY[ J7%v#S¼ )) Jl|l>-1B} QaZe,Ѕ! D^z?X6;L|cpk2>? ꠙm߹{uAXuSV`>YBمR]8dCIwH9gƑ:TuziD*D sŪl! m rד7i9- tJAG~5ʂ“$JHQlqdl F5t|qyf}!d@1b6=/""<̟kN\JKX<aЮoɡgb~U0jTcan/yM84t/&#YPWDF:N۱c;vࡇ^kD=,_6|Yf[g 2肺n<Sdaކ^o `wQa>?^`HHHkj¡ @CNYݳg[ܹs}睌3ŒȀ*cObgNVӈ\12xt &E_!!>4xW˵i$'gnj@N8xf7NdXNh/k.;gL<4} vR;̜|%Fd̬W!>{I}DC,l=>߰FvNAT~{gD7:e~ʩLp!/-v陪W?RG3 7 IB"C05opr~ &o0QoEf1'{hpOdnj嬡GOQ9cYAN`-(ZDA ba_n٘^y'nR .-z`lG!i4O\ ۭ9; Ƌhv`a8zcW5텬BeX=#/,u4oBvZɎ^ Qm3 !>SaƢ9)Dę5eLFyv e)'-yu e[6~YuDF2HW$uHL j˂@\FNyfq6je=i)@f $M-Mwu۴{ɢWTǺUSᱢ!ih I'>. ¼kڳG8V4R%y;y 7gz3t&{>fL#s$&^71F0*8j6uMNΙ#]^]|G$$$DYY5_l#rf3̟@~=X^ +!owuu(_גWo6/AK'dR]ݟ8geSTS\~5lMx,q͒;V||z 5X:}]8JJJ"+Gs4mǻL30< I7Jts݌5ְuKF 2!TPgRX3ɟyD7dJJJ_B@5I'!>+K;$';&q[WR̢_dOǾѭ2{1}jbiY*:z^olG{GN/de14}4e4V}61MsPSO2#xr&,dEO;DQF`f4נs8t^ $}"ŏr8{4GIDATpԤA᰾ϔLβ6yn5rEu]P\qs')>EzpŠHve8}s4`4Pˉs'v% N糣g)CMאN}c D9ߑDo3V5Ȫ_qNBA> (AU Xf̀q'U_k.Pal8bccY*_,\nXq/ɬ_>fѧX4r(x}uc ".GO<0>j]w5=遪) JcȢ3 f?atc-[V?29]8d/iWq>9+=)W|ıSٍ 8}bKm6e5t"&c#_'neq:yGlXv3%ߊ* ? ItMEUܧk?BQ'E#Vy?z(-!RK5exW"' N&9q0-:Rn^l9),CX$O>M yƒ<:$d ߽ 景GYrj<71:y\&Ud2n~pLrbzU-HiIʎRQ[I|/pwsG+++#QUhol/Ir (N葉QV} Co#9r4 !#} {I2iƏDM}| gs#Hۗ$2G҆ig0V7^AKR.ssV#K2fIL8"<>wm:}0hNo}ICT$w-U'`Z>=Է[Y s%ڑ Tohj踦kf#SY{LQiܺ؝*aYt(X׊ ϳ~]T41}4M^zO1x&BpX8cNSQ貶jtiz /&-%YrC_-4(L/JiUUiBEALD'#GaĹ+|aݏq;=&>Z!t[JMUvY::FD'$ 3|a%]_C̜[|f*//ovTrh2i=:;DY\I2aqS0u|Ϲw?zDx}yVf\Er ӱG]8q44WQV}DA$>.ᤧ?7Du:v>bV8· ag 8i]uuCs55g=KmC&kN8'R]wcTRWy @̳mRZ6h)ɝ 0G>c[uy!xfM'GD1b^z)g"ғ32Aԗ #4&"ᛃy!:[>^}e_dHZ&eUxoSjv3V$zRIav4Ihַ+ b"hyڳYbkzEfo]K?38RU%91{Kx,TׅVAT+ҫn~DQFQꛪbƞ 詝T7R^]?7zKx>:N|w|lXvDXHGTՕPVu} ZkƒY~ 4]w>gm bJ+Or9ubR-TןcP =GMG; USih{?QXA+Z\muyLFdC ˾AZ0DA"/ˉꅌ9x\r=soCv!`ho S ]^ep[-Rs%7_KyiOpLc.$FJ`=iĹ.yr/&ޝH;xw"q.)2% xjru4сWbi.gLTF@IY}^uImse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue na b 446ac3==1ubinding site for residue na b 447ac5HH1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSA^6^  ꪫUUW  ee Կ֍jRRԵ/֥R*PP꺨CZ֏Z?/Z֍ju]jZBR֥ZK֥֥KKjZԿZ֥RKj_j_Z/֥ԿZ֥KK֥KԿj_QPEBQQZZZ֥KB?*?j_j_Z""DDAA@NWfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=;vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RES~~1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13IFSB1G  `ee _MjQQET?ZBjuRBԚ֟Zj/?P꺓KujEEZ֢ $I I$ ' $tUBc f$BUUUUUPD! %UT UUUTBUURB*HJ"H$UUUUUPIIUUTIB* UU@Ԓ*UUUU$DDDHB*DI$H $! *J$*%UUU$B! %UUUUUA*!UIIUUUI""""@DDDUPj$!%UURUUUA*IBUUDDDHBDDDHB*I$I$B$T"""IUUUUUU$UUTUUU_vbinding site for residue so4 a 451ac1hi1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_RES}}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl b 451ac21~binding site for residue so4 b 452ac3S 1vbinding site for residue so4 b 453ac41~binding site for residue pge b 454ac5EH 1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???0K;27p@glucose-6-phosphate isomerase; chain: a, b, c, d, e, f; synonym: gpi, phosphoglucose isomerase, pgi, phosphohexose isomerase, phi; ec: 5.3.1.9; engineered: yes3IFS3ifs P 21 21 2BߚCB,???abcdefabcdef???????????????@[S@r=p ?  AAAAAAAHHHHHMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW A^aa$!        ffff fffBfffffff fffff ffffBfff fffffBf fffff fffffffffBffffff fffffff fUff fffffffffffftffffffffff fffffffffffbb."r        fff fffffffffcf fff$ff fffffff fffccf ffffcf fffffffffBfffBfff fcffUfff ffff ffffffffffffffffffffcfff ffffffffffffcc!         fff fffcfffffffcf ffffffffBff fffffff ffffff fffff fffffffffffffff fffffff ffUff fffffffffffffffffffff fffffffffBftDtEtFtGdd)"        ffff ffffff$ffff fff"ff fffffff ffffff fffff fffffffffffffff fffffff fUff fffffffffffffffffffff fffffffffB.leeY%         fffff fffBBfffffffBBf , fffBff ffffBfff fffffBf ffff , ffffffffffff$fff fffffff ffff, ffffffffffffffffffffff ffffffffBfffff!/        fff ffffffffff ffffffffBcff fffffff ffffff ffff , fffffffffffffff ffffff ffff fffffffffffffffffffffff ffffffffBfffaaso4sbbcl'eeXcl chloride ionbbso4ss] [delebbso42s?=@=A>B?B@ACBE  Gser :EDFHJEGFEIHK  Glys FKJLNSKMLKONPOQPRQT  Gala LTSUWXTVUTY  _leuUYXZ\`Y[ZY]\^_]]a _ser Za`bdfacbaedg _phe bgfhjqgihgkjlmknkolpmpnor _ilehrqsuyrtsrvwuxuvz _glyszy{}z|{~ Hglu {~}~~ Hhis  Hglu  Hile Hthr Gtyr  Gleu Harg  Hasp Hala  Hval Hlys  Hval Hthr  Hhis ! 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