$:3.6-1h /data/swissprot/ 3G1Z.pdbdupa 1BBU.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Structure Of Idp01693/Yjea, A Potential T-Rna Synthetase From Salmonella Typhimurium[/h3] [p]A.U.Singer, E.Evdokimova, M.Kudritska, M.E.Cuff, A.M.Edwards, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3G1Z" target="blank"]3G1Z[/a] [small](deposited on 30-JAN-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1BBU.pdb3G1Z a_3G1ZB1  1BBU3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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BA$I$IWWW,WWfW #UUUUUUUUUUUUUUUUUUUUUUEQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$UUUUUUUUUUUI(a*binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???DD$?? Z@ Zd,d1?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2*&PNG  IHDRc IDATxy[ywӮh6{< YRBBKBI4-y[ IM a3!P4܀1``}v\Ig#,ݫ{9#9ϑA}T'DYEU$I%IPd9% KX%>OR)Ġl !DI<%d놴`J)1$zʧ$9#%F/%șxJLI<%r$9SO)DΔS"gJ)3%șxJLI<%r$9SO)DΔS"gJ)3%șxJZ*EEUڻHRr/" EPU Mq *eV"*U[E20 2T'5 \),!e 3@ uU ](0-э$2).bJ)2,D HqL m1 [@u.bx!,D2izBtx ] %)"/`:I#%L,a1a̩.08F.IFw Y L6WKXX{)-.I"/MgX&B(8Ҽ˞V"lBd[8zNK}8A#2˗//tQtFn})%ij2Cڬ6ӨϚ5kp݅.F!Wj+'ض?$RImB#ȈHB5enA9.-ae*3YR0, ɶB-"I͓L& ]u?nđ$9oeS~=$ dFxDГSGwKK{]IYl,̸Ś(BælhيiZ_;tb"- ShGu\.Wa P>T74L@K!"e S]'LkߟX4~>ٱ +Mz"='jj@ 0a(J0w\N'ӦMGin eKcL{D䓶+mFx,k]t7t~W_};w>F[l«ʏ~/cch[J@tШƍ:#<[oڵkXhBTnذs]whž^ey|k_S}}u'ݻwhѢG3@ ߷oHO:Bأ‘$9㺑ovv>ݻq,_38!ַNj9hSUŽ=S J5Qddks8Nc Tp^4/f̚5+⤔/XT( nK.MxR1|UTf\/HGj̟(8RF8MӘO9e H֧7^z)cǎ׿u~ TaӀ]UUaWg-wqg/`^9szq(,dݧm3Dbx\e4cJax- -HgVs;v>`ݺu_ƻE5m}rH,n 4lTW4 P(4Eyk'-+8D]@]/j"mv['=y[4S6m>"yhn*jbnx}< h^{x' +rkxҫ"n'ҥKmab1AM4E4ESΦBP,khV8f͚5=-K{t^o޼gNs$ƻƻlU:t^W`' p `oCtѷyx]e8^upːӸ6mZw7eqgh"빵w=p~ߠ*WG'dʕvmpp']N/Ƹ6a IcDC)b3ԆsJ\p/8t~/:\.H_؏ǽXߊnqdf͚a A^w_DEY(UA|t /~SV'jgS).,{/°xxgg3G}T0<gz5ߘ+Y=λ>Vdib}9Rk|>_bر ׮]˿@.0°*~/kPg,M{Y<<~:)zϓzΥCeYq~W쐾Ҳ'Z|<ƚG9困h_+v+#0)h 6E,{ы/E=Uʕ+3Ǧi%T˪Ux衇/Ճ< g/M76v AǔPzB!uWW_s9'ދyAgMqpA LR1{-2oH (z˓.vGQ'-x^:wc ::G,Vq1 LыtL># {*lݺM6xͲe3f594"ab]Xe<7ǨO iHg-Nߺ,^KيXY:>?1Jꊬ + ,k--h:v$pK.pa&@^dz~(SkkA=}}~}^<\I$Nǔ)UnMɜ+zuE5q~2 E%EFNCTii 1qb>/Q&uvphnEPYV2]j{~ә4vNMu"I9Wэ$XPmr)根xa.73m}QV{imm_oQ&0v4uBܛ3:/")Sph̖-=WKE7FЉ%kݗKs %X6& 1yXдi|xĘ13jy饞 HK{m ٶ@CE>;Xezg1$I=AҌѕ6N MLiGRcF2o72R֘eYF8_\ c{Ú Gx~oО6$t#ţDK}DjnAkǑ+/>) H$c$Q 3a&{*XvOw9xhn|OpϞN>|^{[N , v*>+?#+Vʈ%ջe!~ LC[}d4dYfyUO1 3hLj{ɮm+F'^rϼrרIAO$վ>œ$e`:e "f 4mm]hjĴ +tҥ\|ʈǍi+)ZOLȄ$;#FP YV0L=S+gO_ʜyHo68.Ą N@U|ڕ@çvw`Nx"+vD%C<9oE"m84maj 2N?B12SU1ⓙ[G舲{wː:4440{v [Fhzjf Hc h"=T?T[s/3nC!匿&?Ȳ޽̞=@ H,֒YpK,: ,̝;@o|cp /lmmQA/TUGhYVQ[@$cIp9}TU,CU`\jnUq8زe 8)hi,A,?|#4M3N8 LIe]93Ϝ)$Dj0`ơB<]{jnh4ɑ#l~k,sZ[ Ajk#71N۩KGEcXٗR[5WdNB+( #PVC7%kwرcǖy֮͝w^ʜ9SillyotڃB؏{qttI^ZndB(YDº-m׉̵yp ӳ1vdg EPU ˃eY~@p0=2'"K ]-޳HEH+SvhroX"ģ莤J;?}nCQ4MFg'N`Y+NWWmmۣՕ w7f%%Hw, 󀹀HQU Sq FQ8NnX_z"hn?ĚMf/Ã"3>s"j*, TD$IvpΦSO (d;y\e84ͅSsiNt#Ҁ˗GB[_"'6E^BowNrzIdlhR! D;M#N>t#:3NJvŮ]lSK#/v$>HtEZ3+RڷJ=Ou zC=&2q I*I#2Be8T7D{#p ǜS$Ʉ"ml!n$P9mY5AWEVS4$ L?CShj::j+E.\Nq+UTd/`oٍ^㘖A2u">ebZ& is{rʯpNvp <.?WM1 ǑQ8dVFڻg|,l1)&P)JS_3 Mu` :L*DMQa$v{ͽ$~oS&-ÝC6neIDBeia&q9@X흍$QX!nqԝ'0AIDATN^6F5"G:I$6춝m/h-lcW}[oz847@mBK_כtԯ\<`W ib$Hli8!dÃHiܕI~.Wrp8 mWޣ`i)yBax,d!w]E$BKD'pN;BQ:Can;n$H1"N±t#>h䋮HkoT-5yjv{*p|Sq%Σ\03/^qJ&=vEXݕdpvzD2,TU甎a{nJ@~Cw5qIPI["O0rOxD5 CÝo~4t MT.Q}nËCs1~6O@}j,,x~fO=;V%A(4_'=> KFe}r#D{W#mi8/=y䓢TNpg Hpb(D]a{>Ks |}p+4L^sǬؗ_N4ՁCsQ^$}⺓RLVK$MmOJ^bќ/2j1ﺭq)U.,  _]~r{ɰcĩ֌A4Bٳ[>kX²LzX<\/gO;Sh3 ģ/:MC)g*JW?|xޗ:L=k6HdI*A&Mʄ)ٽ{7MI_A/TMpjpbF90z* u)'{>'jyc8(5wFx"J$A4"$$" Ρ#9xV^7eTMYg شmՀGBs"% w5QZ]^+$ش fs  v`r$N?BH8eڍ0m™>N^qjJ C7A{y+dF$6I=N<!)®yLp&j1~V?|6[Sl~!y4sBK q;}>|r >o2 @I762_q3p9lU S'n]C_t_,u7f86z1a`/[˩㕷{>Cs QW5 $]f[qe.D2F$"J>'AXH13S5ˏ*kTױ{ᢛ9*e*\`-NͅK+0Pi:Fey8BRPdG?kCaߧ!LTEؾݜy^:a.P ËI={q9lWIэ$-OK'HWڪ4<F`r-D,˲۩z oIENDB`move=1000;blend=1000;3G1Z > > UUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ee ֨?OTE**"EF#ZP/UT֢ZTZ֫[VHj#ETQ']j#Zj*5UV U?TZ֩?'֩5꺩"?TQWI! BA$I$IB"!I H$Wf#UUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???FE$??`;6Zd+p-<?`w?`w?`w??@@@x@x@ ???333333?333333???#~j????333333? 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hUm gʔ)1uT2uT1([qp,.Az{ "3xdjP9|RT-@MC}ws+VhƸT)i Gx$m۶9gȐ!| wzPzlbohQ 3UwrW5[nE=V%=?k6l9`So2c&eo>&NȪU-/]4_YMM -jgƏώ;?|_9sWn0ܖa8UxƇ_ 1mɳ;)Z{.*w>=h(Hٲ6}K_j*&g_Q^m<R8p999A] Ɩ} s4nܸx "9^uF4"~Enn.ׯ}XlO >BA6j7Po=Z `%wi=J!ɄQ/R^|EVZE\\u] Ȳ gPUUդgac|ps1!3ek|5 .ȑ#dffjoGoh ::6LWK^^+W{m&E>)C}7p3OϵUK 7$v/_ ^{}Zinn.FJ`ժƯ7kE#FgϞ5q@) Q*d&[Bѷo6~5WNnbÆƹaѢEA*Z'e dzm5MTC4c7p?+V$t?ΤI9r$=\9=nއ*;|esZlK69;F9}R _H OTQ_A5<?O?ݲzLn喠 5'er2kC޻2}={t,_EA~M3!C+]Zg`܁A޲f۹s'c<(h8p #1z%xP>]SH隮2.u̘"j>}:'Ol.l 9 Aq"ZSO=o~K@B~Ք[}T䓚E9R} ]<>!࿠`DQСC 'E~52׍=6r_|<7O(Rg!Hl&&&Љ2OGF Es4@_l:jɒ%l۶ݻwo\ E_ | k6uz)~t*4FXP= O\EGk7tzݻar퀇 u/ 14y? lٲpr^*-WDJcVmQqܸqر%KhX̞=7o?{2sPi+ߛ.m5Ν;o0V7TUU9+dΜ9 >\ ~{aݻyw60~x.ogy[v /{WtlV֍7믿:Zmɞ'ƚ@Ϯ2AjA@$=a 7nK皓O?s[hM6ѫWvϟb6E!.CP󫯾bY ܏ ܚQkx'8qD_4Ȋ˛|'qx=lLјQHH߾};v,W&##Kꫯeڴi<ﾛ{9s}v cn:.ȽkT, Vps/^W\AZZYYY 8nݺ e; EUH<΁iшz]c&ƁUJAaă鈋n_ahPﬥ*T}`RN2F ;i>*k5/JBsr1YoI~d\n{0dzFn6Tmdu\jJ)nqU#ꞩně)V|κGLF/$ƚ ʚb{`e5TՖRUSJyM?xHo#tM*ByUaM"'тF#FQu)96jWQDY9%'Nb*kJ).l7ߣ &RK+4s‹ȓŷ'V[_Iׄ^Xqfyk0ųMERʪ 8p|[3gFh+m ; `~|5!yj+IMA4RVU!Wz׺g]u"ʪ ;]Bv90^Hh%.:||0|6/y?&EmjK)T|m"hth߈ T.;s ]zRTvD칀?m6=**."*p]T YiJD&戞|' =U 0m^z]_XPU *R\q Q?.3IDATI$FӅn  s]ӯp@Q\URRq6лb "_'OXTUfVNzE'y W/wUP E'{X[VTY[ncZMFj6uHddY$#Ʉ`@DDI3aPlEAf$Q5(<n~2 r{Xxom[(OEM16{ FC.#2taY  =Y1<}{ V6>c-EqmF\PC9{[j#U~<Qf?5[퀯ܲbőSytO8z^3=14uXRȩas>o?uBޚ[U֔571]I҇9GP ƹC'c`'VUQfZ3k]ȬIe>LѱC&o:7#@ߨ^y 02q!M_dJ< !6:u=G%d9A57?O GV4?TSOXz6%IïAo͖ sC2&38Rep;߄á"h O`؟!J$;-/=?qJBl2o~Xsuaq-=Yhh0mwP&[ܲu=5*!çB B$OvW-`0b4 3sɘI1hK5#5ƆjE$ W\2 KSXr’cx)=kO ^EU=ϡO)V`FV\Ȳ;_'B?%D%(\=mITF*6w](4$`YhZ[ bmZa954`H**;I4&+1d8osAǃODIuޥ1DEcIl28K50~ J<jmTT!A""C3sc0N 0-X2OwM Fk6/2 3#cE Lblwv$mO.h U [h`Hd]`l"Nm{6䋆 ^<jm FNZPPr ˆ$lM|p{Q ۃIA|LW-8]v+Nc0i)X-<_ 񧪶Q-M)SHDǒ3j^dk#xjlz xI2epT(ǔF?fǝ.IENDB`move=1000;blend=1000;3G1Z > > ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUPQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ee ֨?OFTkR?TTJRRT**TkjIQD_֨?j#ZQDkQQEF#Z@_ZZO'Z&ZWU$Gj#I$!!!!B"$ $I HBBBB!D"I$I@ WWWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU**UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWbinding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???[[$??H? ! {2?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4&=PNG  IHDRc IDATxwdUruu=ӓs8C(.FPX ""2 a&0'ttՕ=֭[]_ 5uù~" M2q;ŵ I$QFYĜfx~Tʼn$C2aCeTEE5A:0nU0ܰ!ˋEUzqS>PdY񸊈GNIQ5,:kD(UP\vH$qa#  @f'S ЍW?,+@IVDb)#KB1;zP[5ӇƩPT$ھ:gnJ<+/M_T]u M4ȩ4;Ku MeUV𺋈Ħ&dYEMKN($ N~u+@S~knRÄCA]$imyg iI4-.t1sIF"ON!na'Qdx"J<!~ p:<8.dY%{| !ǎu+sW^&4}_sw0BTAC)Y ~p|zTq^hzT*L2t -){A;!9)-#%Βgp:8TAR>'\'[ kO,h\.t.Zw3?|IARg3U8n$IF}DKɢau ȏ~xH<;ۚ DMOBhKfdُxu_Ȳ"Ȳ,+g%ϛi)e_wo2óC=gsZs*($IF N5NGJKN,yb,nN4=E* L%HbR iN9l'$!K )-$IHH˨X,yÚ.ˊA IBR$\x-6YHۮ׻++0$Y!ҤI4$O Kǫ'zw5Ei(4Oe{H@JKN7ydI()m$$[ `m_]צ<>O1( Tu{+YO.w3 Tp-ҀEkd(駼ˇ4vӳ MOE,QoH,HJKHiI/b K 0V):*n7%yRZp|ḛ̄UYa: P]oak4?tEu4VPfdz-,yL]~6t!\.HwVO MDY\NqMN:;/w)Βdž .@cOv(u!Ĕ$"$Iܙ6e%#Fh0k6?Q?U% %EW/`q(7}ҟ5dI|7c@D9cJ+ڟzۧԧ,yFaYyhzC'.#|8mJmm_a;"{J>gZ6IdYSԷ}.H],P%lЬ1'ɐ;fF\5,$ZOg{Y=[f$5YÚ@L).\N/D"#]"- IҊlڈ3t<9q=&u1R4PcHYNHPT9ydkȲ#gf #%]$LO@³Ɂ@Eg4J U@';bosg,e[ʨaҫFa9cgüU rOJڬ T2b.vѕq^8KqT ǟ%q/':"o)*3O:,yACb@>)xRW6d)͸5lYɓ-UMZq΅Ƭn$j]I/WUV5^uy3 ?5vef{M%-Oye}0cyKyJЅF@[UfeTd齯wצ-5ShTp}u/7.+|j+ei ͑h`BT}E68usJmmXۚr^uo_m F0#P]HCdT??_b6.5#ٺJ/~hB'L4 wϸd||kK7 j% UUYа͗*r<}E>!`|5'w|Wsw0 =N&*˃d$ h7^oDPQODX{4F)AŚʏ IX3ya0#ɓL%jH&8,UpqEg> > 7no|h3gv 3qЃB!:FBu,l\¦&϶%QW5Davcw^YdpB1qrWOzFmTӶș1o̶|3|_vizɰRKƒE Ytyt$V.beD*8Qd&*@HMo~?Zۅ$ ee ;8f&Z@΀AK*eFtGqAIB5kH3",4EUēp$#9]css~nb [(wU!X[[ LC0d9-WP[9HSȞz,ZdDVyQ#3,)HNR.?Du+&C?EDc!@[?L"G`绹c̾ߏ׿{|.?1l#RME TZը1=[4r B-(,# ɒXmHƉCJU\wySBuBp`kkX#ߧ-|fB |XN QDm;!rr {tӤmö[C$Sn7Ws >Z;;PeY8 h82.tnӓn8?ke:8}}ً7tKÙ'``/L8cD5\:ZHJYQ- SLi'똑gil߾M6i&ټP_p7o± $t9QկZ3[ ɇGa*;ou<ŴuMK 34MEiÔ+@{1/2[K.s|]."z)i @_,_V&Wzlt&Kɐm8\u OAcoMˀcr*K'<78q&L9V%L@%OC"bѰ1%х6aGDD*Ɯ1lJmfW27zF**ؾϞ 0?Olp~861V5vcm m7 4Qc49tڲ:Kh?sWh- OUY=~ׄ/jHYFʋkQU'<'|Yt]cbOZI$E`Rf<|3,+Vr920t6:Yoɼ>3ezϒ3G)D! kUST-A"(.tݹ揄u 'sh<`[-jH>o ~O1O?W| Nnk/0⡧N,/R!uxe߿qM+ H36a `NE_՝{?A_SuuqnN`F>p]s'0 "W!2.m:p.v l۶p8Ϭ@5;H&9,)(S̎K>FqQ%N{˝P$ԯ ayc^:0܁:*K-KHPOՃ> Gfazk~:H6̠E`;e$1>3ַŅy5|=/G46-ߎ@0&[:$8Cx]E(C4ỿٳ5. h@ /t&#IyHb(ǻp<AQ T*]Un0E_N_EnLD2JRKP|xj':;;Yf `Wj ˊ2~%2:5׬+SK8g1E{]MîۊpHH&Wjżj~H/á^C}|2MF.mk0>O1˪wN[RTS[ba55-4)ۿ ~o)$W-vre-nJ §A$OFQd"lhwlH=Vch( [}GagO#:џUc<䗑I`*7PrНyF<r׳o/;]~|/"L)q#P.I|}Ou0d)twt4ޛQÚ'"S0WJ^7}Kj֭rE2=g-,k9]ӸoP+'+L1jVXmXx1$Q[[kЄOS{w/_}h<~ϰM|.~ZԪwN=է [$/ ev]wbZ6lhb߾Kl",l{zV1XFa6'05yK{˘SYOOC- i]N]|J*8w,mH"?{K*ƭ6|5װj*?|.۴ a'b=7v& WkfF#oχvÐ.E;~]!HQPdPd*&RсWi/> 6H3GJ6~HVLkf 64GI憃ǟcaz*Gó?cA4&W:AVdUq['3Q>CkNvw4s/f$qqBO '@IDAT3YC橸P%{vfeJcgsh'HS8,N<ϑ/qe1Af)Qt8O`Hsج 'kcm/W}aM 9+沂"+S:9GY:t}'#)wmxyw]5g+$|hWsǎ]v p+89ّ]M3m$]&j(*#4Y(L~0#g2Pem:^≉3|N|bTA`a SUބSuFƒySL7_>ke8w0݇߸ʲj= ~oYhG6Uܶ`  SSBM<6M8_lwϾ 8I.̩${ ~[=D[&Sp}݌S ;c[ dyy>4" ZɈlݰ ά.C=D `׮:]wm;ǻ ^3]<ӨN{kdTma#hdJ$Vͧx#AY ӻqp/!{G;!(]@:.:a7 cz]ĘIP\~n<?E46ۯXUU=%\ڞ+Ϊw^O(B{Qb3=G9sc˰ۑm) g$ >j8Z2w3W"IDԚbY$ŒPL=좪k֋Ք*(S/20EIQ$ueIk_ĉpPs1˾M⡫7n?l^y59t,"z=lscX"b$e6=CG_a`e5"+WNMU#%*?Xe<5箾:{ C^Oi4]MQTSm*@v,m9.?,lέ[yY: wxɸX> -qVofZ6o̼yӎ=ʂ`oQdd*NNv췬ꅄt<Н4W2<4¯3$Pe7DdҼ4F=fy˨XHIQek7$v)/=:ۨkȲju!!rfχd*J'μBUi#HQ x2@ kzdcsMei=3w4U8]tjH sA[cnVq40j 3[!t;ʑ8ֶcvsm  F$@fSzQ#ӎ44EOM.]AܸmlD?y8oꪫX|9_Ħ/5$SqzNqcg4OZ#}6즫..;]6Rd!>COӛ~<ͼ躞-}}sdDx-ZqSU-J|`Džo`ՒgL wS_5j}ԖضXlwckz7|1rW5"f)o&H_j#L%ȊXG͵Y> `tt3/1)k:]ӕN. R u}rZewC<a M2!w 1EѸd۩Zk 8`X{ۉCFQ5b{t;̓"'4R$o_"3*HIH)[PS1o}ǞiI#yꫯ~7\pJ#.\3%u$S zk%Ouh*DġTE޲,XnuԢxP/ -V:zrCvfp$<0#H/ERoy?xq?LII _}ri󊫩.k4$izc6vфF(:ؑrEiHx6TA$:Bzj7]⤑6N_~I㺊r?04C,W.X{~봮vm188@*a 3G'lמ\eԲ:gMdx)-iT̸ػ7lēQTa8e !%h-\Y'.t䬟qy_p%L +`M˷brI$>%sRf#ւd~fM+FU/8Ѭa5 NUQ#_rB.6.q_+á:MX6ҡ?vl>^>Xf mCd4>BUY^wѴP$S z!Q%- FINk*㦙{FS.t6 ."h'o䣔ְal^5o$8ٶ0F?A$Jd0æƄ#Om"TE wZcIO͊ԁJ;qj+#˅ y|uxYx+B/L%xo }hŠLn3#WvF[N[3PtĂ]>x"HdКy꫌L; ƣJ g+*om8o[q9 r+>$F} O/fL!el-(3ezYiq1t!8ֶr{J#e#;q>8TWaҰH_2KwV5I-WX@p]~FhD(.p30ԝ]bۦ[y9wtvEI=v]`~niXHz*/p7㷃`N1Ǔ`'W BA3I$DmMfciT*_vfvxgj<"8T'6ǟdelae01:dY!A !Iܣ9JL*yZXU҅'kVdpX3׼dU6L5Ktڒ8 YJwKMڤ [0P6b&br}2Jj)4-9&wLPSbIwx)ULu{0D^.\7.IѴe&ߎĂDbA#%rY%52@g[ -hm{XشަT5!IcKcuUuI<[W9 w8sIp.ّiGQԼqc6PQZ3{fV`BBڎ20L%H&c$1:Hi)tbw ]hc6-ߎa$<4)-Hu7MjpsPUǤfBS 3"Oei=e8Nvz¶^x{tDM6T]:Bz!_ "}a=$F–Cߘװ ԇ,;:SSPEV_H|w.Zo$EΓ/eB4LƸd- Otrh|.Tt@pY5jԟya&kP bƶ2ndL%(W Hld*A$>B ӍšN 2GdIN]Є&u2UqC ˏ[3}$OvwoHI'4B~dd$aH\.ٚk#q8Yبc28GaID2HFDq:=,ٴCS"VE{{ظJ =gpvǨtee Y .Q`D7̚㐉%s7!KUE'KG)6mGyn "kE:jj;s\y f3ɶmX46`'{QdX"‰ÚӾQ,\LTa}Hϝ9Kuq#UE8_!3: =a){JQd]"_BͽX"IIUuvfět #'LbLCDbS+,7P&$IB3GahĨ Y qqYrIbY'[cdga_~ ɓ.̽^wBdU>$h:LPoĴ;ii̺fofΉɣiI:4ZeHdr2b>ٙSgcz4Q*rzхfN~UNqɣȪG4J%HiI9 wXN2o ])wpu#%V1X$]TT9x2Fl"K{-5ѵ2NHH&R KZjz QsGLaJ:xX<$It??0.fKl_~l£# jzKCm̴vi)pmaֺ1vThl[?:>!,)HzHB'HƦOYOTb g ]L`Glo%¯k\jrF27_ RZ[ƒ֗P&D*F$6B$tL?<$ae0,)-td 2]K:C`!Wmy ן-ؗg-y9x9"`!|uQd%"% :=q6F:ؾrŝ8#$`g,z&#!LkĨڗ<g"lXvEVdpH?ǽo4\.,Gi\T*ii# s e\cxE~,;Of1{2+죔IԮG70m  3&gQa׫'=(4YRЦ0*6f  R쯤4PMY_DU(|_l䙝`SKϹ ]]2.j$IS} G^f ؼꬺ` _&_?T4=LPUȒSqq:t٧-~ZiB#$Ky/T"\XRӅ!CŬMӋ,OXs !e F]!:DYMs}vjJi,IHBIbsҨ)F6!/i(nGmɨUJBѡ1,VQYV > UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUSee E*EEDT֤UWjjT֟TjJ֫[VHTQW(Z֩?TQTkQQH֪P W֪֢I֩?IVUIZjIHHHD"B $I H$D!IA$WW WWf#UUUUUUUUUUUUUUUUUUUUUUU)UJUUUUUUUUUUUUUU@binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???kk$??@^Z @`'5@{3?Ъ?Ъ?Ъ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5LPNG  IHDRc IDATxw`յ?3WҪwY-۲-WlM7!!@IINBH{ !B1ـ ȶ$VomҮ*{_kw;eϜ{ҌI!3۝8ITز PQ< @`D}yGNlV6łRC~AݍL.jgRWs%sVa8$58B 2 ̘t:]{vqߑ h$1s!ض5"   OCe" -hh>C>N{ _O? _N'wz8x냧(/zUKU  fgSVX4By*D8Br2inÌ}d^]ʋVV;V ņE CAPZ8ln/- BJe II $ I9rI^kWS#i)9 Idӌ,1gUi8Fk1&ո@}㾨Kg!رI"rQ_%?kLŽi IX;)zA$-BAeB_"n"Ó7D4&E {G_ o$QYv^yk~7Y$%/Ad0Ojur-ʝ2`œ´i Bm.,yS)ΫnЦl ݈*'ZR/k>&$@YQԈXI8s@o_gBS2w5@|D().][Iu9O"p8/>b[Y:Y [ߴchh>Ch`C,DX.J Xltz[HqgP[ɄL2VBS8P!T(J+nh.  *x$\0~B!]?d;OR&LNY$e lr0rtjÚ3GB@(EM_cE3t1@8DRRmGhj;Js{- dW:Vͻ:Mtz6J0U#jk}Qtbx$tt7 iu(`Cb|GtQF@B%+}u7%t9#wa q~;wFD[g]'nLjJ&V\o3!%⹃I}5eM4?/*M |B>@!:- _yf8u^;=jR5}eB}~dI ]r;siۆ{`s0_=ukܶ]=mQɀ!kaIL @QBL< '@G0'+P;j,#}~v16%@`OKϛ54Q׸֮zhl;<*,x@ՅT,Ci3gˑmd@/lA$z;EC!%MP@(b44=Iͱ5VmVF2Nm\0rB(e_ҹ dBWرZl)H tx\vx0d.TU3'}da+w|X,6$jl=xAyQuOe0ͻ^# z|_rҵdgqE㑿cTMr"A{wbv>9))jPWd!E^ZPe!\حN:a5さ`jRȪYV񍣬U=e.[H#BPuyet(A b$iHZgO3P##f #?8Xw:,6m?Ћ,Yeͭ1fMJGd~T'oN{g.2Oi fM^OY _\ A;.|hM枑(dW߅ۙbn$X"n 0g'ZmEWO+7i6>޾|^}}}4|Q$Yofj7p#II!` *=oWUM?mN 9O"ShAv~/No ަ؄c(vԔ= JVdȶ+Зu`n6DD:m&5=iHXQS!T]cBQ-A)̞0C]us?B&%(-8OEt@aMmGij;3dؾun.w@?@Ggw3=͆44䔓YÑDœILfB^bB⿁PPn5;a zb=F]OawۮRt*! 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BA$I$I!WWW,WWWfW #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEQI% 5UUbinding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???EE$??t@&9@N1?g?g?g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6&PNG  IHDRc IDATxyx\y?w;dɋ6Ɩ8Ѐq4O50pjp(?x掜ϩ~C=U0nc Eac\BU[TRW=YV EQPtPx׏S]{xLjaC|"_DbAt3n$p8\E-`.]Np_9EQxݕA O8 & y+h_W>D8_e(W=-KML*58ysNO)ZyZ4Չ8PEsW梕WJjf!K2A$:_$ODŭq=&pӫ9SiYQzD4>DPxJo IpJ]JAYR0M!0IO!f4"S-H,Hx_xIA]]/Yg*VG̝}*>w557-WGWoeJo-_%!L1ϱeh7.͋U]Sʼn'4sbS3 F(b]PTW6<]Ƣ`ߛE+W,+Uq(.a<~)LL@a7Y =6w3px"J$$ 20G04JNj~jjjP|]9ODQUv|ΰx )jyL5S ,#,:g᭩I(:L Ok'TUVWpjghjXDC퉸>LSg,ZysgFo8(Ko/Zy"!e<'h',š:QPlTU@ PN͍Se|VQ_ـ,8TUhiV 8z..8LW{!Irx+ Ý"b(Enz#a κ:ֿb g,N<?@bxE+0\N="շGY jop,H8: y#t#@c"%/lrx+h  ǂ.fQ8 i\pE)"V$V<ma$4H``HUѸ/xY0+ҚDW(֑wvUÉԓ~6! 2`32_Qo4T]*$,AK^Dqj\ÝloPdPd˟_0$Uca!H (yp[pMhP]/_ud`}8.dY7d3ٵﷀ@kz^$IBf`ǧW8p(rE]˝ IV%IH^ZsT㪴ƪ>8qNF$5 Ǧi;p'0nWW]z5 /hq Aa)r6>V3e1%,OLu뚘 3aX[DnI:*{;wq;t Kѹ×i¢)-G}&M9\kr;DP-_~8+pj a_UpOD1Ŋ.H>D"j;yY+3XQyeUZ$IŁ$)v)!,#IR$D ~c28%KߔcF'qUf=%" !0?{=y@jv=֮mcbF[H h>,#nY9MiWE)^uJrm'x@C#=-{Se&-ǬI©z!Es+/t#r2@(Wg+4R[S8  4Y⨻Odvb0.Fz 2ĥyF-:A\V/ȥyǩ-@ue}˭NpgՀi&:}:4;@xn +B*7BjAj_=|?`/B`uF^W%É0Yf-ۋ4v )77$wuuu>Y ; yD1?a`:߽u_Gw0U A8''FuLj6*q:U@6oI9 GR|3W4Pi X0pqWx?B# d"H?\,= 1z<ϞádI#@WYn <3L@KF4*Pۭ1 wzG߁EsEv$:D4`z}IYܴJo-*<dŊyȲw\Fma&:7D 08p@ ),\X(Fx:ȿ`'aV #5{hTU 6nGs\N/վz+fȊzN sMaN?pd5c8\'V::~$Ib_$ ,H IsTEbVG:yo#Yb*ۤH=kњaNj.OC"ݓX1 t?ԎM`/,4.T1Uxep0SfkW{^'Xlt J@W =iHXjTEepsoyY,mvߐQU-oQXhQ='<ݻr:x&**\޼ JnWXԭ9 ӲFn/d_Ou5 fJ@%ij+h *Xr>_*+]3$]}B +C/b񺫸h<̣3U N\f0ҨosjvAu~2|P陱Pb1ܣ 4M%X$„ѳ*~,WGBYiw%_Z?*b|in\G,EiKLl-e !X8w[#L0 k`8;UhTOjNODwt\ ˊ+=@Da|azx"]ɗXK,:fb4s($ &-JH'ocH04ΥQH\wY<ئ ]á}̏~4ܴ7Jo wꮹ1q7~`]]W=BD'"htc%W{&)H4Y߃ʄq4MM)h,[fϮpPuPL,sݴg=~˨֦;*.+*|tfKb0 =>Nmc:I ֋xPH$ s֢(2"vkx4!wup/ɫ1á>ku3tZ95[.4) oFuO7H0\+cq,] wA]P[xޤ7si^EE>=$J V$®/IiYZ<пk.2BW :::'疙 30\uݓ%)J\9C$8Twj λhiiikk㍶I{> wIH.N_2o <(fYI0 çٺQE?hߎg~eTsF<둑}|l!D*t{$4Hh!L>]~T<5CN. #0T'|׿W\A$AuVXqc~xyES']0>:Hdvhʬْ;0i>z4nܸc+V`ժUx<l޼7 {GeN 'cToO[c 3 N$띾pY Rc?l+vevZ_U7ℙ'3ϓc~>l<9k7K/eݺus9+;0{wT)dڭNf*55lo<#?J*tmNΓO>a11wM6fx'Blݚ=A,m0C<~TV.eWk xmp6s.w>&*$7of̛֭7/Ecr1r:M02i8ĴT$Ww7uu? mڒ!1x\h";XJ yaR{B; M ф %ђ;հ9h#;v`~;G|M齞jf%If8`yW/.N-ow|I:tw&?Rs<(cʽٲ-seu 6\b3|[ ~j|ks'Se.ϽϢ;=l=0Ķt Yaߓ7oD܎O,,bg,H)&rwhWH6[x8$YN60qIm ObfΝm}֭{m2,Ok+W]uVHߔ8J<23[ٱ$IqD,n㢋.7'Y}=?[&Ul{{;NȺupdzl!%&V\ɪfhjʽb;eCxe6M~"幯_;7 |A?'p{傔·iLLpTf&|ڵteID}BrH7`Ba3MMGyܹsپ};>hQ?$IB!.]O> f`k˗sEq=vzTkCM^B ݆&呧hn[ov㎢sWyk/~ r]|ø\.7(BkN(uПeJ@e+f04RlGQ5 xgSر;v̕pmP1[ \r^4J",5ϓD Wx!?)L4Ewwka{.VLti? րV{-lڵp֜ VX4L%X/D!{YQ88/~ctBp BR@R 0X MӐ$@ Ñ9Hr<cJ"+Tzk f*k楗^A۠,nK,IeiWƆe2=YLJvV:qV[n!kVԲ.]yǢE馛`YUyq:HL<7[)w h RթhD"2srEom۶C[Dq-: =!D9aOM6qgg<xGFKt,~ 86cWH2 ˁ $8A/`ŭY̪U :7l~NuTG L!S-&6'F0C;ȗ3mmm|+_I=b9nٲ {IՙmD{-e~Dy0`ij(Xعs'#jmʯ/gY;RD)Jpd3;M lȈp T` ,r/&fy,N !Cc|m޼H>԰JKI. H-'MH- WX pQx.Hx`u0vF"֐G%,!y$$F$!J˽@:#Pg?\y( gSl&mb VXѬZvE"gX4773gΜ t- 좲]$IBNp`⁣}CUϦamg7G"Ovﭩ2Ȋ~lle р% l,\6m"[򕯰|rq7ں oĔe$a$DT23X.0;_pvV<>W_}5}}}|9 <,XO>_?i=\8 暌y|Mz{{oIb0Mh8MtvshO8_~9H(|H&{I$ =X5zny~mua:::ذag}6KNdRRjr!^^N444P[=v 6P<L6=|~NmxkҥKظq#B֯_7?lEBY  l%l$fXÝSxb/_G17p$[o\ps~~\xᅼ:LGRXX<\y͛ٵkr^{-BZZZJ&^{ EQRaAh+Y=EA(xw$6kn߷.>N?2{j~)/# o(WL g.#O۶mw`_XO,+#8y+_|1̲eS)1 ibCA{pҕ8}UmT IK0客䠝4Ea\N/mU.h W1=5յ6n8Uw*$oOu 2x饗r^+5Ɇ飶jhW)%Gd$C Ң]t,hS2DbT5sj{ͪ;NSJ*ξOş9rf”<=w2걡vn\<36 eJ6H9a*@d$ieJ,%^fl$SMUEm{p8ܘ, ɲ<݄gL婚)iZ+Ӕ=S*2)hȲ,ɘHTVk 0⁤(,Ȳi Luզ)$t#a$0Mð6͘M3eayk?)Ȳ$ i4 m)h I؊W4M S'bNqFi,J > UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQERT(QQ**5UV U?TZ֩?'֩5꺩"?TQWI! BA$I$IB"!I H$Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???E E$??@?@9@IL<?h?h?h??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7g&PNG  IHDRc IDATxy?=}rɹr" r*FHThT#>'oވhy Ƙ x * (7r,˞sww= ; ˞f>LOuUW5WuJQMH'/fs,/Aڵ@!u/tp[HDb&#%܌b̦X^z{c!'"`HDQ#Gڝͱ񓘍V8@AH.DW0D$c[P,%+ !IH tsGZV`b- f"9>b)=9}$$Ӭ,~Y0d IKVp=rԠV+QU{dElR;? \Sc+')>Cd H>=_w34iez %-)\bm{N@(;.[ qi&dC wBci\wFKPUUpl+w֜1~>]ͮI:$IB'IHI1; "'jyڀ܌X̱ &RsHNdu gE~odЬOiGLT zќIjR{Y .?Hv.L- %!">&,~F`AEB '?xڈ c1 f3w9\8hi}C~!$ k+5_`Q!)&f$ƥˇ_z hP+tz(H`~E@_BA V|vxڐ R1Xq$'dn˛vb.?5 $) $@lch !aicҒHMEӓEZR.ֿd%$72HJ~K?.i^' QB8U}s׉h|_=3eZ$IWX!H V'p&5ĺb€IK%!.BZR1x>)KnFOߙ}&b࢖=8UsKp뉵&vXYkv^2{o- !@daQN8}2. _DGONaMYભ6Ev[ *܍\Vks[ٛ&i_G`"֜Hvz!q;Xͦ[VIrB&lj渎.R8R#eyEBPFEjgz %! U3IىEzr7F e|EPG:EBƘ}6:IN;D팬zQ *1x:$I fΛ(. db1Y_w3V[LjR)Zq{97ڐ8+`1Yq<dŃNgh0F5P=FT<@ÉI+{tu@R|:.w=NǁWv Ir|&)$%d_tst G*!@‘$Ħtٰ;k8\u~5S.#[+TՕaWqOtsD<z^qPk+^Wp$ шhb1Š7a1:1^z{Q?GT<* 91YFV8\Tʱ;kqyLu$1&&~«ofϡ)=O8& #ހhM7PU{ˆ+k6ۙQ%WV=jlW/-OɌlb`60㥥OQ;CeY;/lgV[olEU5ʩ/g,[~^Gc0tx.,V !iq. ݎ?\O;qePT즮5lIDi"+}ϡkx]&cPUn7no{GcTq`oz 729E ji䅣 <ynwp<7Ui>*Z_8P k6=%*sd% 0,ȊG=69q[ l?nY} 2/&)1UU"Z[^}H? jWU.4 ~GRD|&?pez:=+*]6gM1Ȋ[s!gWt"wBO?… C.u9^꺓ͱUE]鉝UP7S:w0$$MD8uߩ a>#NV5^Z . BpG} to({q*h?PqyWnV5r,R3sh;V!H>ѥ7ge<@[ Ej|8ui=$."~˿!?|UU8 тmxHϠ{N=o47-VYQDE/'=9Eq{֟fb灯Z='x#GQ/u`s3Z{ȯ'!. ʺ2Yۢ{j"R*# 5x}Y{9Ǥ**j؝mcͽJJJغu+q1$'d"!qlW ިY f^_|NK 78H<!@vZ͚F t{d?[I[1qM fE:{%ݻ7[ne|Va;q ʮsO PT`}zNB:T6.h.`NHHhwL63^Cj[9'l! .d,X(++ꫯ@5ހxٴsʳV x𑜐s&M;>H-ҥKO~ҮyN6<^uJjl>wiyq6 @Ŏ;BrJIKj}3ݪ**%%!;,-8뻄HOn1颛̱wA̒V7HII!EG6MjK`+xFctbތGŬww3uEچ#u2a~鐑1mt7(2zv)Yj{h>D8paӜ\a3b6nlz1z ^'N?&&&JIaa ,G>̮l{3x`}\=c}1D,.nW!$g:m:ƥ^ȑ#)))i> g ";r"Pӱo-++cʔ)Oq6W.A'驶$d#R:m{bi 0  z=$ !Xp!+_qbyKoֈ 锔0h x:6G893>,F zrTfg M~භZB뮐DL>;@n}#bw8E0& -ZʕZ=ÓO6,սnHIWbaO8> 5x.ڝm{L58k/mҺ6BGN >*P)68>kʇ#*GϾ}Z ܭӁ6NssAǏo9XÖ[el)q'U33bN:ŶmӧOpn{ zNO=W] zm'O7#pofzkUsR|:;lG*kӯp$)*| DkOJ;-6>b4hbqrt*qf͚kV~~T!ti<=3XD JSCb{/q +"`:ͳ (5 (**bѢEq72gΜ^FnӀb9]ctOb.4> `lܸ>IOuawrl6L 9s&˗/`lt%M0uԭeA'I<Ɲ~44tm5D7a$үhdZ-F&weƌ҅ Yhɼ'N`?0*>6'kUW]EZqTl[v5'qT81Z鶇/7 ;ZPL0lXa>5vcs^LV]rmż\{MkC C7^6C5ɉS{xK)MZWz#`٥S_42tk~QA3C):UG?cLzVN:4)^z%>C.2nCkSaX-xn@ Y~Kx~KWZZʼyxW `"mÆ7*OH8{/^ŋÿDʔ)S8p'G|l2^Ñݬ/<䓌?>$ޢEXliii$GZsXx6X杫f|[YA 91FaJ-Iιl!uŌ1w{LL4I.B8f˫)**b߾}r-Ъ^Cp{v~Ꮳiųjժ.BXb, N \p\}[774pl zٻw#w2{bo8XBP]wY?-NO=6G5̞ر[N+hzi7fpqUVd1֩&r ` o۶m~~8:{%LV)SGҩųsFaO0L\ܩuQEuI*q GQT/w]{8߰ ==v=6ޯ~+*x}hvg-5ǨWq_9ɫιmEmӨcwP[XK/GvqahSV8Z#u/nx7RXkAu]1g6q$  k'=O_[ ? K $i裏RXXuWPUYE ux^cp{SY6<^0XKB*kOPkjj†?-E#TŷleiB@[?1L a9k( ZR%t3-e = GjRYdgP^qQyf^r'9EȊ7F+ ftJ҆}8iI9䑙 ) o6^,{sh},4m D?;ѥGy͛7b IdE'QTև-۬(rHT6 9=neOO'Ҍ "\>s.uLBl )9'AoBQ^x*2V s"+^*k&օOzuħ.?̙3'`~a6lv۸$f^rO,J lN+!&&՟Ʒ\;T*SP 3gX;׫0RIK#!6TFKtIBQd.lm=[ĵI&Q\\LJJ >yPΕ~!֥adž+T8kQBі0lz࿛U6vί8GOd8qQ/nKOTTHn T}<1~ -- ֭ ?~Ϟ=믛?x o@({3:Œ:zI,IMƙ8f-۽kC QN3\7&uUk]+eawpxxndìmTQN!Eyg )6A2M))6hեQx~ܶOCVePP4cd4Ñ^x.EuzT!e5w?!*.¸W6LZ ӳy^Zx"<⟌ӳӦl{8 YHorE t1L_psU=Xo&>}Qt=xhh0"+^TKLL, >tRo^EyɲG[Ktp :Y̙K8$IUdEF$ IґLZJ&9tyn=gGa@ 3& ތAoĠ7r8?0wCX̱;jr;ر>=.jl!)!A/ #5=[Gga@@z& 3N!'"L/,XZjl8uɽ ѧp9W cn_}ڀС LlymMsf\Xk";V7nqEnFQ)5:Es& Ix.Z$`ݳzG5/;vPmzݼGJ򜁸$jeeKwԠGBfO\Io-D%X̱BPSwqmXq?t|;=r *z$IQvNmDT > ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUAUUUUUUUUUUUUUUUUUUUUEUU@UEUUUUUUUUUUUUUUUUUUUUU_ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@**QQHJ*U'*U'֩5꺩"?TQWI! BA$I$IB"!I H$WWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUR%U*binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???[[$??` @`9t5@@c2?ǰ?ǰ?ǰ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8=PNG  IHDRc IDATxw}ޮS95$P $!2q6!`so%'q `|`l)FtQtw~{[fcKmg>|>*EM"t]$qs$cXXw% MW4EH$?x`y&*JqËl~-a~׾n}9K<&^U@cOlNZyBpo>7gT:`MDb}ŬYr!"@]B@:D2ONdz|PÉCV ~2HKyr躊o.]$I0ȓ+[r;ArW@HnYvC2Z?^_&Q$jIdI8p)n'ʆֽyS +~?C@anm~}ys~]!Sȸ @CZkJSu],YȒ{= \N/If06\Sh^Z2ٰvE$#u,!  ,ԙ} i$PcisEVP.T-@IؽٜO8gy<}4=$8Xd !x[(VǾn&0Dn]Ld,6@3.LɣkhZ͔BI5FBHH&cH1t*ndsyfN96/a~Ւmh'$]üS} S;؊5_m u] iIO'Cv};jX"S[KpٸV4lxoi:Faj*TƊM$( VPVTKq4c6E!7wf4:9hRPcHj $d"MTBƥx^;_1A_ AIǞ-$ڦ?u]b'H?9ضS:NdlyUBAk[ !KT-IMDڊoj˝}ʹbpۮFNmiDTj4s!)$ 6rz3E\KͭP,q {O\_:g>ƞÏɸ]y9@oغ&Z:1D~<\N/,P.i4]5V}S@>ڴӴg?=9h`os!H;1O0&YšJNbIR`WI@YVoԜt=x=9[XR{6hlKwiNهkRs?b p:ȒHd MKT!rօ[yfB2[S(^M& SL4ƉRKHY6'lENr<R xgt\d:B*IwϨSm@Z5q*n+t]Y<{a/dU2S!L=UMgP[ľA%Iܳ/v?Ԏ,y+LcONEe)w4$#pDcl]{ڮ(gd A{w#KG5ʊII{eьp\|Qu_EƱsȍo,9$@,A0"Op8Ƌ4a$W_$9*it&5Or8P^turQW/ ~򟲶kSW.K`={c59@E<t|=2D!A̓oW9pu>rxqBVrq:=9T?[ްCaWȘKa{P`fQ'Zmqb(A$Y6aGsԋx=AT-rgɼ 4CՍ̪[AdA`;[^18%=Ϳ-̯9!t<<ϦbxvM" $R) UÝ4Ԯg 9xYdY!_M̞W.PUa\I9M>\Smfܯp6GH7]}a>vo C݉ӯf?c\޻хs*B:Pn扗fgJ=&F 3"\N/cF{YTTHhF泪0w)7&㖀7%l`)[uNilKG{{_ [ˇ.t;vy>n:";in 9ky]>$ vn34҃8dR0VYh.pׇ~Prl{)HqJj}-?l}n"cC\~?( EqԾˋg=V/EjDvPx!KQԂ =܏ x7pLˇCQ蛡d4:.4.;ּ۩]~$Iw-+l (p2HT(|>ItL}Ǟg>$/LGgoFq:sp*.Í/LvٗZpMW,܌$đenY@ $Q!QZVByYTTNWCZ:~Ւ}A`jۏsOȳ~"T.-q8TnD./ޗYLMWՠ,9bY>CͽM}Q/8xw02frx=%[q9hZ>%p-sΣ'mCr!%Oc^bcED#D"|Oo0LĔchg-{i(V uzm>I[ /iFSQ<f,6UȒ>|?% 37R`xx_LR:(L ~J5F/&30I5As x˫|Ex~v'?3sq98dG+F7 @F $ YTaHa+O a[s]P,K"L.+ap|` ch^1]ӡw'Deqn? 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'u?ow}0)'B <^Udف$7ڷ&Y s)ODҲe,:#*oA%[2'Lɢb1!)+nǧyߡ, I292܂JAXIENDB`move=1000;blend=1000;3G1Z > > ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUDUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUTUUUUU_?ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQT(Tu(j*"EF#Z@_ZZO'ZR5꺩"?JjIHHHD"B $I H$D!IA$WW WWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUJURUUUUUUUUUUUUUP*binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac913G1ZB1> > >ee ֨?OFTkR?UOj*?OOIMjj֨?ZTQER֨5֢ZU_j@USEGjRjZn#E$D!IA$I$!!!!B"$ $I ? {c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???HH$??5@ȶ.@@A?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? 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{c,Bt f EUUUUU$DHI$H2DDI$*$DDDDI$"""" ʪH I$UUUBHDIBI DI$DDDI*I*IUU$!BI$AdUUUPUTI I$I""$DDDH$I$DADDIUUUP5I$DEUPU$UT U$UUUBI""$ I$I$DD"$UUTIUUT"""*HBI'binding site for residue amp a 401ac1]_fi"$1vbinding site for residue po4 a 326ac2be1~binding site for residue po4 a 327ac3v 1vbinding site for residue po4 a 328ac4e1binding site for residue amp b 401ac5]_fi1vbinding site for residue po4 b 326ac6be1~binding site for residue po4 b 327ac7v 1vbinding site for residue po4 b 328ac8e1ubinding site for residue cl b 329ac911BBUin~n~*TT ֩?ԏU_T)U zbinding site for residue lys a 505ac1*1?333333?333333?333333???????@???0K; t?sputative lysyl-trna synthetase; chain: a, b; synonym: lysine--trna ligase, lysrs, gx; ec: 6.1.1.6; engineered: yes3G1Z3g1z P 1 21 1BPB\B=??oV?ab??? AAHHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW>aa _ftffffBff fffff ffffffffftff fffff ffBtff fffffffffff , tfffff Bfffffffcffffff fffffffffffffff ff , ffffffffffff ffffffffffbb {ftftfffBff fffff, ffffffffffff fffff fffftff fffffffffff , ffffff Bfffffffffffffff ff{ffffffffffffff ff  fffcffffffffff ffffffffffaaamp rob> #buXampadenosine monophosphateaapo4s aapo42s aapo43s bbamp Xampadenosine monophosphatebbpo4s bbpo42s bbpo43s bbcl'eeXcl chloride ionawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262awa263awa264awa265awa266awa267awa268awa269awa270awa271awa272awa273awa274awa275awa276awa277awa278awa279awa280awa281awa282awa283awa284awa285awa286awa287awa288awa289awa290awa291awa292awa293awa294awa295awa296awa297awa298awa299awa300awa301awa302awa303awa304awa305awa306awa307awa308awa309awa310awa311awa312awa313awa314awa315awa316awa317awa318awa319awa320awa321awa322awa323awa324awa325awa326awa327awa328awa329awa330awa331awa332awa333awa334awa335awa336awa337awa338awa339bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193bwb194bwb195bwb196bwb197bwb198bwb199bwb200bwb201bwb202bwb203bwb204bwb205bwb206bwb207bwb208bwb209bwb210bwb211bwb212bwb213bwb214bwb215bwb216bwb217bwb218bwb219bwb220bwb221bwb222bwb223bwb224bwb225bwb226bwb227bwb228bwb229bwb230bwb231bwb232bwb233bwb234bwb235bwb236bwb237bwb238bwb239bwb240bwb241bwb242bwb243bwb244bwb245bwb246bwb247bwb248bwb249bwb250bwb251bwb252bwb253bwb254bwb255bwb256bwb257bwb258bwb259bwb260bwb261bwb262bwb263bwb264bwb265bwb266bwb267bwb268bwb269bwb270bwb271bwb272bwb273bwb274bwb275bwb276bwb277bwb278bwb279bwb280bwb281bwb282bwb283bwb284bwb285bwb286bwb287bwb288bwb289bwb290bwb291bwb292bwb293bwb294bwb295bwb296bwb297bwb298bwb299bwb300bwb301bwb302bwb303bwb304bwb305bwb306 _ala  _thr       _trp! !  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"#!!%f _glu %$&(-%'&%)(*)+,**.g _glu &.-/16.0/.213245337h _met/768:>7987;:<;=<?i Bgly8?>@B?A@Cj _arg @CBDFMCEDCGFHGIHJIKLJJNk _his DNMOQWNPONRQSTRURVSVTUXl Bhis OXWY[aXZYX\[]^\_\`]`^_bm _asnYbaceibdcbfeghffjn _procjoikmpjlkjnmoinqo Eglu kqprtyqsrqutvuwxvvzp Ephe rzy{}z|{z~}~~q Ethr{r Emets Eleut Eglu u Etrp v Etyr w Earg,x _proy _his(z _tyr { _asp| Hmet } Htyr            ~ Harg    Hleu !#' "! $#%&$$( Hmet!(')+/(*)(,+-,.-0 Hasn)0/13702104356448 Hglu 1879;@8:98<;=<>?==A Hval9A@BDGACBAEFDDH HaspBHGIKOHJIHLKMNLLP HaspIPOQSWPRQPTSUVTTX HleuQXWY[_XZYX\[]^\\` HleuY`_acg`ba`dcefddh Hgln ahgikphjihlkmlnommq Hgln iqprtyqsrqutvuwxvvz Hvalrzy{}z|{z~}} Hleu{ _asp _cys  _gln  _pro _ala  _glu  _ser  Eleu Eser  Htyr  Hgln  Hgln  Hala  Hphe  Hgln  Harg     Hhis         Hleu  _glu$ $!%.".# !&'$(%)&*,'+-()()/ _ile !/.026/10/3425237 _asp0768:>7987;:<=;;? _pro8?D>@BE?A@?CBD>CF _leu@FEGIMFHGFJIKLJJN _ser GNMOQSNPONRQT _ala OTSUWXTVUTY _aspUYXZ\`Y[ZY]\^_]]a Hlys Za`bdiacbaedfegfhgj Hthrbjikmpjlkjnommq Hgln kqprtyqsrqutvuwxvvz Hleurzy{}z|{z~}~~ Harg { Hglu  Hala  Hala  Hala  Hlys  _leu _asp _leu Hser  Hasn Hile Hala  Hasp Hthr _glu  _glu  _asp          Harg   Hasp" !# Hthr#"$&)#%$#'(&&* Hleu$*)+-1*,+*.-/0..2 Hleu+213592432657866: Hgln 3:9;=B:<;:>=?>@A??C Hleu;CBDFJCEDCGFHIGGK HleuDKJLNRKMLKONPQOOS Iphe LSRTV]SUTSWVXYWZW[X\Y\Z[^ IthrT^]_ad^`_^bcaae Imet_edfhlegfeihjikjm Iglyfmlnpmonq Ivalnqprtwqsrquvttx Gglu rxwy{xzyx|{}|~}} Gproy Ghis  _ile _gly _lys  _glu  _lys  _pro Ethr Ephe  Eile Etyr  _his  _phe  Bpro  Gala          Gser    Ggln  _ala  !" _ser "!#%'"$#"&%( _leu#(')+/(*)(,+-.,,0 Bala )0/13402105 _gln 15468=576598:9;<::> Bile6>=?AE>@?>BCADABF _ser ?FEGIKLFHGFJIN _thrGMGNKOSLPTYMQYNROPMUWNVXSTSTZ _glu OPZY[]bZ\[Z^]_^`a__c _asp[cbdfjcedcgfhiggk _his dkjlntkmlkonpqorospsqru _arg lutvxuwvuyxzy{z|{}~|| Bvalv Bala  _glu  Earg  Ephe  Eglu  Eval Etyr  Etyr  _lys  _gly Eile Eglu  _leu Eala  Easn     Egly       Ephe   Ehis # !"" !$ Bglu $#%',$&%$(')(*+))- _leu%-,.04-/.-1023115 _thr.5468;57659:88< _asp6<;=?C<>=<@?AB@@D Hala =DCEGHDFEDI Harg EIHJLSIKJIMLNMONPOQRPPT Hglu JTSUW\TVUTXWYXZ[YY] Hgln U]\^`e]_^]a`bacdbbf Hgln ^feginfhgfjikjlmkko Hgln gonprwoqposrtsuvttx Harg pxwy{xzyx|{}|~}~ Hphe y Hglu  Hgln   Hasp  Hasn  Harg   Hlys   Harg  Hala  Hala  _arg  _leu _pro _gln  _gln          _pro            _ile            _asp                 _gln       $      ! " # ! ! % Hasn  % $ & ( , - % ' & % ) ( * + ) ) / Hleu & . & / , 0 4 - 1 5 < . 2 < / 3 0 1 . 6 / 7 4 8 : 5 9 ; 6 7 6 7 = Hleu 0 1 = < > @ D = ? > = A @ B C A A E Hasp > E D F H L E G F E I H J K I I M Hala F M L N P Q M O N M R Hleu N R Q S U Y R T S R V U W X V V Z  Hala S Z Y [ ] ^ Z \ [ Z _! Hala [ _ ^ ` b c _ a ` _ d" _gly ` d c e g d f e h# _leu e h g i k o h j i h l k m n l l p$ _pro i p u o q s v p r q p t s u o t w% _asp q w v x z ~ w y x w { z | } { { & _cys x  ~   ' Eser ( Egly ) Eval * Eala + Eleu , Egly - Hval . Hasp / Harg  0 Hleu 1 Hval 2 Hmet 3 Hleu 4 Hala 5 _leu 6 _gly 7 _ala 8 _glu  9 _ser      : Gleu          ; Gala       < Gasp                 = _val              !> _ile  ! " $ ( ! # " ! % & $ ' $ % )? _ala " ) ( * , - ) + * ) .@ _phe  * . - / 1 8 . 0 / . 2 1 3 4 2 5 2 6 3 7 4 7 5 6 9A _thr / 9 8 : < ? 9 ; : 9 = > < < @B _val : @ ? 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B Hphe  8 B A C E L B D C B F E G H F I F J G K H K I J M Hala C M L N P Q M O N M R  Hasp N R Q S U Y R T S R V U W X V V Z! _arg  S Z Y [ ] d Z \ [ Z ^ ] _ ^ ` _ a ` b c a a e" _gly [ e d f h e g f i# _val f i h j l o i k j i m n l l p$ Eleu j p o q s w p r q p t s u v t t x% Eglu  q x w y { x z y x | { } | ~  } } & _val y  ' _glu   ( _thr  ) _pro  * _cys  + _met  , _ser  - _gln   . _ala  / _thr  0 _val  1 _thr  2 _asp  3 _ile  4 _his   5 _leu  6 _phe                  7 _pro         8 _phe                         9 Eglu      %     ! " ! # $ " " &: Ethr  & % ' ) , & ( ' & * + ) ) -; Earg  ' - , . 0 7 - / . - 1 0 2 1 3 2 4 3 5 6 4 4 8< Ephe  . 8 7 9 ; B 8 : 9 8 < ; = > < ? < @ = A > A ? @ C= _val 9 C B D F I C E D C G H F F J> _gly D J I K M J L K N? _pro K N S M O Q N P O N R Q S M R UC _gln  U T V X ] U W V U Y X Z Y [ \ Z Z ^D _gly V ^ ] _ a ^ ` _ bE Eile _ b a c e i b d c b f g e h e f jF Easn c j i k m q j l k j n m o p n n rG Eleu k r q s u y r t s r v u w x v v zH Etyr  s z y { } z | { z ~ }  ~ ~   I _leu {  J _met  K _thr  L _ser  M _pro  N Hglu   O Htyr   P Hhis   Q Hmet  R Hlys   S Harg   T Hleu  U Hleu  V Hala  W Hala  X _gly     Y _cys                  Z _gly          [ _pro                 \ Eval              !] Ephe   ! 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