3Nf3.6-1h/data/swissprot/ 3ROI.pdbdupa 3RMT.pdb'[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]2.20 Angstrom Resolution Structure Of 3-Phosphoshikimate 1- Carboxyvinyltransferase (Aroa) From Coxiella Burnetii[/h3] [p]S.H.Light, G.Minasov, S.N.Krishna, A.S.Halavaty, L.Shuvalova, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3ROI" target="blank"]3ROI[/a] [small](deposited on 25-APR-11)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3RMT.pdb3ROI a_3ROIB1  3RMT3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) 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J+|u h0ECo+ k:z9}̍gOy뒦)WTy&&qk{?t cM[dd[G;0,VܻyDC=cTB.74-{=l4 qLw0`4Y\_)h/b2Npk2!c E넊*bQC$ `]SEQĎc6k56U4Eu }V V?n! Ih90L>af=oICԧ&sb2K&>t$!503_?~;bV͢FAS,eᐍ|ߘQ2tDi"t+IBN>Uō"\|~=µ}yL\X$͢9.6S+6\z8N_x)MqߧcQDCY)sdˑ-h7,XDb(P4em$e4N.貌* Cz c.r@HgzߧgtИk!}S"?8k>h.V3g^yg[-DIBE,F7zpp:8fuq7URGS'יf) #:ǘȧu/yףjDnAeũ|}ep8F{!a $',+2ʫ. IS<^Ί); 9d2kZ Yx8CQ8:l4,,0u:8>t} '^g! yL|gc+8hoye{EӤ9(ŽcnyaJ,VEb`U׹X$#ˈ1Sൣ#ƞB6K.C5MtUeƞ? lI< вm QR,Y(bE3 OAHKQXQ$q5NT$ w.?2< NK) !e8,}0@ ]:nnbF\{B귃N7g FI~㐱,y2'Iq̆&Nd %/IHQDX$"Ve t2!'(mlKuqx84c K `Z<n0QWǶiM&$ :#CMS("}FA!ܘLx1 `@FU!|?x9 nߘ/ؕLape8yI.IH键c2Ń,Uŕ$:1]ǬVi"̳֊(1IFn' ,U"[,ҞLS,cy"9xI63drtm (clik?WG[[\=:Bs2jGŗVV7#IS. YYF$4I, E1vp\h,fTEǥK8.UID.GU$N)γ ^"R |bpwIµ/>y|{>|4) S_Z"IŸAQ8A{̌{waX3MLIb:!D* YQyHE0xν$7EY&">SǍ"&QD0#&y\Unw \t:N<{%zPHI,2kk5 C6AP$oulHE,j˗iF-/STU4yĚaiGR.G:n@#& q!*q!AENj۳RB}=Z퍝A$6*9Zg4bo:EsrQ vܻw7\.niϩ$^_\fp-f,s>/-.%]2,f, ~LSw:487(_7;i\+}h"OA|OOX q~ g xIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13ROIb-f9 f* 9b" 4 eeeQDj. ]#.M3mj-Jkݲf{jX7^(}"}~|D)jJ>DH/oK浭gqW8ソl`p )u/V %1в}`l'`qc LL90m*T#mgĩ[lm#ĵZ~yE'UBduњvHZ6׳͸=!G8J QX! R6P> Y9Z9mZ:ι`@Kf ,)r83Z8mYfҹpG"uR2Z*k߽߽0qEy<  Ad  SpN/ͩhLћS_ozC /&IJ~qL. X>"nppN 6c ,6,ۍXI r#k-s)^-Z3xґZ)?hW+_QE j7ۤӫ6^]$Q":0Dh\hXX\LH&lBDGH â1QpHL҅.XÅL6 2 Q g$HĈQe硔25:BO4gJ~R2(PMkTc[!eʚCV OXfs mmqapNH[mi[r 0UҬBa+n6 ەmepV@{ԼQJO<-&a):ER5Wg;[ԚP8V֎RQB~?5#ŠGngn@\Z1܁Kgެn668b#7+Zֻcro;Gt}5|k7y]^*ZyJ^O.X++\{b3gϾ];ty}_9{;ogY9{=gfk03c`qh'q5 ީp)' { _A9qXr p>a:a, p> p6VuJW 6a+n8sr8 mJP*TҶ `gZq0V;uunkAgYyqXgX;ֽk9o>ʤHi ʝBuHTQ5y #f͟6-K W}Sz1{_Rh.T< Dʧ*ˆP>#PhD"B0{D;Ǟuݗ8jyn*Ns>}j(}y]ijԊ ǟ}מeHWU3ʙ*]UaivUti *@\.LU5HiEQC QH&gh Z~J}gJ)Gz^┦s>ގskk8sN1=IC 2/O< 2<ξ L2U8UXHi $Gϗ2\Т:H|hXtqё(аdFG b1H .\aB@s B PQ@'D82:G[E,oZRDVִTlR[ƿJ:/*Zety蝆(uC Ddp& :...&(# (JA^:hf 6hH@ a1 c&ʠ6eF $MuS]5eYy4k4Uva]U!1CdұE(aŭM$QEi}/{j*_Wcgz(9qnG<={m:6[9}{8_QE(auמyeYyi)Ec{jlW{=wǬ0M,@thZ?uךieR$]"P̢:t҇"8.t/>0ĩְٟg)}9=;{._0/(okC}j/x_inJ}3e"U"(Q(L# 2r% (4*Et8$ C0p/ tP1  $HQM ,Xxxx1ˌ B@\J(iDhQ @\hQi4҈M>eE̟D|̣Hqt "PDGƇG@e 6*8XA (2H(HL踸訰Р<>L!:3I:t'#FhDM (KQHMDQƒL,D P|LP%$Hd"c#ɐ .* b28,(lEJF A@Q p HHwAH`$81}Rvv|F̎>ёpxT1eK&@踔XJp~Խj晘}j&Mn>3hEpl5 _֦Mwu4ITR55-=oV ViJ8=5ujLT$ TTב3۝1u'ʪ8tp,IPP2@ R~?LR,`ɳL  D9YљYCba@2 :aRVւ lؘJ8D4EU4L0uJ:ƂD%MRwPZAEVoZu=/5,䢚'.8H5)vi_NSJrJ늗i[I.hcQUEI੶*UNE3"8&Y a%CgX&UM3:Վ@m)вu,rG,v#靲zjzm,RWgcjfVj%JT,bJi&rJNRw H!FFҢ,l؂,5M5P4;J䌬QAPșT,$O9 !D9#h]r5MD)nLr==M$x%FʢM%r]%ю @U̍T > 0De#m^K ,q*#GB@DΖ !HA@bPa"c`Lj@p |=)$ӡ\ɱDA"09yL }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???$=?A@/; ?@ɞ?@ɞ?@Ɏ??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superpositionP5PNG  IHDR0 IDATxwEǿ=e3ܝz ޝwkp *dL`QQP80`BÀd6陝Ycçꮧz`셽 !P {&EKq.^ =mAw \6yΌm Ru{ xڷw7CX W2Z`904ESrs9gk._ k?徝k_]UyPK0-XOv|Ug.UCYxإ/9Ë=P XfWV@]h!yxx -gPe#?/~ r<܁z`zpDk$[ LN(R_mcl`+P,peo\WwP"N>ʹN.@⏍F_ِyr&^=Bǧ DZ  : !\&*b _F95 /קto]|=*}LUnLqz1`͵& Fcb+㬝|3h>z>kUR >oX_M>w+1M}=i= );gvS-;߹}g[ڸ'j Nef`zߞ͉{mϳP0hO ʑ\r?Ӎ[忷*UVr<3zg*HOy^2(, ZBHX0 9cHba8Y|ةOK@$į*{ӕoVaLqC߁}I[QqƣbLW?ꧣK*Tҗnb__? F6ϪU˖V|l0뷱5Z*~Ks!IMS|b  F'ؕ&`S7FɉeA70^#iNBy6>I,TM!`^\g|q(R {'y'`OMwy1ul؏:y$DR1˱ҩcE2V¸BRV髴f"@CfH'_u H X[V(; .F䷇ܵ|09+|7dW&D$zh̤"xI SQdFC۞ ` wk`5k9, O(C~[!]K/y){>?i{~oC;<31[jղHFF3v3ƁG~atRtK]q'Cy*[+vn2ث` T_B*T q CN83NL- A,PgL8XYѰQNsM0.-KѲ9f +ckiVT"Ki#M 88bF3Qe +HaI % 3Em$~D|tjFd:ukT9<| |gPV{l2a~ѵ ,phJ[ܺ{8 h\ C4 ׵$uV͑YL1pb%{lP#EfN3~qݷB+&dׯ*uFo.E|0.˜ H{~ l&,0!`1`!a9;;|{דn6)oױkw$,Ƨe< =F7uVtcC! bH{ubvb 5OzҎB4I3̬YJ(%S xnvCy,K86ĽFb}`S`M+ٜE˹%ex.W!11`-҂ZZTϪNfVfz6G]EK1b@_7᯴%83D"Zzԫǒ4/?gY =`h1oVT|BB$PAbL8c# , \)-lYf(U$l$tx XF]/=q/LmԵVHa'l!J_)*pq#R[ ,F^`KZ(Z[DA^-mC䏁:`\u{O!)bjrGAHp%ȟi\<ӷ@ɶb/B3eO/C#!N)so!GV,"[# @al-Z$hoD-̆0wvZ7G!=qFe _C!`=Aךd2^Zo69|)q ﯈*.FS\PkȌëV!<`V?h@h /a۫Pa_O&uuqMx6D!J U<|)^/jr3Ĥp^FG[!xP1`g6ŎH~ L)a'c!!\&j}]աg00a`TB/` $At5-3Bu-zNEۯ\W8;ڇRJ  Oa A AeZ>i(pd(7^"A[8cTF\ǍѡEmM&_ 6*sɰ@ǹԭ5C^Ћ)Mo.rr8/27lKDm쭰/vF0l6p!+=GB|;FkxP0dv!6VmȰ|O-!i0*$2gf}$N:ƫC-0.$o'X`nb<&`xWJ-U,!ݴ=gt> \.63Qp$Z56̌>ǶU'%21a``DŰA;eh`~kp/\O=t=`߁bC z̙qz4>J5Xa#N1H隠C&0J#8Y%@ z E4X^TĬ͛Yr|Ѷ'*@+ DF(Y]BE'"!0荣ЀKvĴCd^17 Gc>"p|I }”î'3bYu3$$BBͼ9Z0 j JJXjqퟂxA~Y^e#dL8ˀ#g@Yu/&Mg[b fg`!ݍ*^#|DYWi%I_#[CgH˝:!N!$lSZ0㏂]$f:`#<-Mx $'ׯD&>XLJx >=7:^ Y"ym5z+ `n' Mv`KDy51K)Cp9Wp',W1+݆H&ڸ=t <)niv`< LC${ ~yC;ސ>Hh{hOevv\7pNP{7ŠB1yH<{7o)/ >h -G=ì.Yx_/TJ1-ݸ>58ٞkmΊo?Nv'] #G,#7|/ǘ;"q:cwy%mk͵(xd9|s>N+mә68'~m2Z`ku퇒-2@|a [.qB(V# 9hgQ B{pD`<-/~&2d{Ps\<0<$PwWNrC[0!abVwѦ2 A= h"ypDiAH`@;Ji2^1}Ľ݉7{890ȳȄn*pȺԇ#l~ V>T35o!=`R8 yh3.$!N n]ݽ س`$j3pb| }$A`ME tƹ-])Q47h.3'ySpˑ݃(ӿ1(N\`ۼ-߾PsyzT%hgK*9GÀ3 =sv?[gs Alg)7}ң$ƍ<&/*B.^kYmÈ+3SH_wtDE5pZFl3tW3$ q6EY"ޥ*\T7ю>A;3dGi' VMhD/^EI'yԩVj n?h TY)E}U$L>G#(k/ >QV8@!IA=9PgEO!33Y]R²HG>0zSҗ ю54MWH*а+ _34σouЬ1H#M&1g"NsG!X!Ԑ;`Oݿ:E9nƸ[yƅXOǐ'oa$Goʤ~@b|PkP;9;Q^RN q`WD'._&1C `cc#Dq}  v`+׷rs>J|4G 3^4~[~lq%Ycx2h,YQxo( y(b#l nՊ!aRV*Thq1u7 LCQ <7;0D#m AQޝx) C>3OB"NcQ{Jvx !V0$d.2ckqpڵi<~oEOܮ7Ѓ09h=R;SR9~]PS6T1=`"|"B|S_~Ig[ƉO'ϘzC ŅzB!NmMOGW<>.I8?MjGMBt-HAy=S|Ѹ#Bf=}iL{YC7U*W"W7KgS|9~2;q{*+`9t=Bv(ܑzzrZG-mq mBoǸL㒮姹g(ؐq۱@.O/uXTCŹp`yJ"]1nQ驮?rߵTR-0 A*'//C[T#np{CRBO`̀";SL wæ՛dbB=MژLQ;юaZ(_lߙ+=WuRQh0ay;ؗ 3T Ir\əhҖ_!ʵ,9D7F7y4\JQT-P)Q6pnHCϹٌyppmx d*ԁ#D!Ch92gMQŸcmۏȺ;CRHS۟DE RNGcGE3ɰewőg4ףH1(Sz=JJR+*g GSJZ#!h[2rM"f`lw}E@:@ZFlW/ȭf(UqBl'!l *>Sh* FHq~OW{69}l}0hkUT\%oF71ޓ]+M=PI(lPį>;NHpg-QAS+A.bm?⼽  L>!MoWOdrʛHad~S7(hnzGwb-CK_Y2j6˳S"JϳQ[b_GfKHI_XNaL>k[y*Ҹr .]t1Զ<>xz v$n~7wVcN= q6Vnrr^~` RpP9.<t}ZjKBuDj+%o  L̛Rܷ;B&,RJN"bC1}Pjd-RƒiDd0 //{ҷrۭwU;L"bG"=%YHq*ݔ IDAT_G ]|SW:B!`8"|- ! Ҥ!'v?󤭔)PK<0BsؚYдt I⇥($+dAri HPy PPf[69үz@PQӋR&K@;^mI+L)b " Le :)V@De {yH>HD\!9;Zmdz~@qkPvf*D2n'/j@qw,feZK Ӎˑ|li>at=Rc&lPq"" |[ %CYsa]uɽg; x,| rpEn$ǤuBomu>qU.}_MA5pyWvCzbIȒ\Y68ls^r(,.JBSwnի!>BP1^ 7ˠ;a sS-nćws4H1WQ!#|Dclv>ݶyaH8@B'㶪*6ǨJf4ΖMx \zO7 ^ 7 "yxr*y><|-;y`峺Ce;%Ic22k'S}oj5z* af©GJ5ȩ{>s "P*; *?'v"&K 9=s hl8?p7-Cj?D|zL3pP8u'__']yqwɅ΁c\MhqGSҞxIixbcyT(DD 7JZ)1CK@B)F= ژ2P0̀gͲe6SJ;a9Hj 0f˔!(T}Mֲ-K$X E fMhJ\|1&ޥH:-ӭ tמ51n7nA~x"n;_ rH@EK:WrK3(l5fc̏xǸˈn,.-Aq姤xJETmJsnJqHT&1JZhߑypIT*6ѽ,@gp i$y}jpr|z\yJwރҙBl(R@1'*sP-+0 8&9KWVG:QOlzCb4GIW`Av6YddԇO!@ߧc~ (Ƞay1j/qa B$n3|߬&'_, 2_+YiM8Υt8%б& H + tMHU;ܼ1.]JN⨒i~<% szJ#0|ðvrnEg +Ah8ux~ƣ۱oo#bWRDRWcJ˕rQ;o н9]BzFf:ȆA/9  տy#,*cl;4A%׉Ovga%-ȸ0LO]zا٤@|*h)r exM: 6EhuDA{Aۃ1SfpŨ>N.8٘R-S2@Nܸ^Q&7KG<$,UK|*T=w\# Ô0t) l`zO;i, PnUpSoBѰdzuή]h=I޳^X"ϧY'!B:VؔM,m f8 ^O/ ի(o~ 'WPԥrc-8mr DEXNz Nm7ǩyش`01Uت5m[crEVX_<Ȱ+Kbb?yb˜*g|SRsScG|Fj/O@99ŮU~ecѹkS0l`aj׶y6 ?eempFjmPYOyZ`J3[?^ASyj3?v)f-?5$}<>e}e 5Orl`V-vm{1+ˮu㋥%V&yL|w/;Isҽesr+==&T' Dmm=dNzuՙWdžyY,Q{bs`w,ދ8;W.DAs '(sSIvA8n&`A+o?x/w6.K݄!Vۺ4bbJN>dr#X}ړ2K¼vr¯Q;07wx[z+_R<$8UNˮRa&(V,=#CftJu .r}܌\qrq)(;[6sm7LF2ݵ&1"Á%C<{Mx'_LAcR>s9#RG|+נ9`pq4%ם];Fz\y=JqR%k/י BJO%|pNR4yv}7C4" y|yRJQZFt!2ȇXr\s'!LHӺqPc$rNw]#Y4>74'`?8 > BWځ8 Y b"ָH[>|1a"±2R@ȏAD ҖwR%M "qfȬp[T)W8 aw-t@DS9E'8)H4E oTs$[mQNp{~h]zM%zua\|πJ_/wgi2k%ߒx~M<,cneL>ߖU&P %i1ð&-mTǩv)nay[+|]X00D #XgzKj֤fjnÙN/ëo:k"@hD{ԁU~uC-7}a[e:@/#4R䃍@EECl:8йOK!j 1m̌P4;J'{VORVhН?:IR&zq˽N2Pc*~Y{ SMv4i\Oׯ@68IfRڼ=F[R@QtC sWOGr  \?e+)gCV;[Bcof$.|+,g '~r(9.Ĵ"QlqW%hs~DY_C"w&`o+c> K^4H>|e;^H|1]k>.D𫆽P(F rCmr]^I~(` ( d #[QqRf<#^R~H{aGO|=zUyélKqv 6}a/ m^e؋8{a`/]v [u,IENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTd2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROI(f9 f9b" 4 eeeQDj. ]#.M3mj-Jkݲf{jX7^(}"}~|D)jJ>DH/oK浭gqW8ソl`p )u/V %1в}`l'`qc LL90m*T#mgĩ[lm#ĵZ~yE'UBduњvHZ6׳͸=!G8J QX! R6P> Y9Z9mZ:ι`@Kf ,)r83Z8mYfҹpG"uR2Z*k߽߽0qEy<  Ad  SpN/ͩhLћS_ozC /&IJ~qL. 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I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9'*b"eeTiT֨?PRI֤*TH)EK*UGTQTkTQH??#TQԏUZխHEBԏ]iV*"#j#[ZOTQTkKj֭jGI$$I $BI!$HI$$II $BI!$WWfWW#$ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???UskU$??}?TC&K?????@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3$PNG  IHDR0 IDATxw|u3 C tEBP"ry͟y;+vXDAPC 5mvcfgwnv }v|f?  eN 'NDą'"‰qĉpDD\8q"".8N 'NDą'"‰qĉpDD\8q"".8N 'NDą'"‰qĉpDD\8q"".8N 'NDąL`șܥhąLR~K" 'n]C\8!#4u u~+͸q/- [s w?1~o뽋kƂ7@>} V8\4BVoNwEW3:? }(rXފЅktmΝWkr!`Z+DZډTL4]E|hErBaWt!9t2:{mʵr8^ׯȒO$ jYe)M3EM4Ǣ>|>/-^4p8~j/2ڑ/EaQ)Ǡ<躆(82`O8|"t-9*ek,BȒvVβq4ذc),΍E$Ytvk ąu+;&5z9݆# IRPdGw&qV7U>hznK 91v5ӼNw|.8YRxwSQG w#@dٿ"Π^Hk,ɬ歨/?:>M]u0E $#2$!I2 *85KQAZgaWּ[ &]gx)Ȓ.QYiRњn֐#LHHh6N- IOiSdoҵILH%UWw!kxNxBЅJ%iM$$0E#@ף۰ě:=LSڐ7+ ^ Hf3 +Tg!9PdM>Ӻ34ʭ W&qDmCK6hƛ_R-{y6kȊ[Hƣj0$g"ЄqXLc% ?!Mt)ú x}n^'ofw}+MOWQ}^K8M)[kVhϟ]wem2btRKB4~Tkk e9:_N8Kld櫞yn6^y1kA /a_;\4FdMN8wDQ-[nLuc̻\o`܈h ~">Mk6S{??(\DYkޅ}G̜9WϳjIl+c\b b\ΌK>u(pCfm"mGxּG[x1g4}$C@׭s}p"]chJ~۬k5[/S $:[+W6(^xE1)|-seIݟrWU).!FU C07$/Y@pA`.L$<͏Mps!n15..ETQ]@ͅa^34\uUr\}}f%]]h^n1&!U8$F$.wRvXT7T> x45a{{[w[âת;+*Y.u"!64plĄ*qz* u3u֬Y .wUUltjudks| xX. :w]ר&jTIUΎ'%HF#藦Mկѭ\{LiNN𒚚K/՞$Q$Gin.]=ie:"spw_w@Ttx8LΛ'Ï l±)vD̑Tm l=]ZwnK`ʨY|K83a?%m[n/.; &yK͎ν_k4jU~NZJ&FfjJdD·oӍ MQ]\2֘y>|'=/E\Ocg_, E m{0wr\ OO,]  =qQKxw#{=Dx|S4G|1 I:R=M8ȲŒK  8ZGwsWa^Sq:c;X_:Ϧq󣖏SS$I\8G4pv`],gJa>Qr믿/٭@MBgP*bź.;Y}p;璙E%=ss~@[d,[B= ?;=3zN6ݸ jy4o4pv@Y1ʫ4/F;PPOmz 7 s_~er u[-OBe4s[JsUNO%GqNRb}:5 /#:NU'`͚5o%~9-gwi:Eejv|Ox~in )(iX~!X@kpWtز3죤nO;hpmĉuES(yק\Spde(.O5+p(SLaС?~xt]gl۶>^m8XWidwљ1()I>v{v{cs/Qw ̡n8cǎS^^lݺS{͌3Xl×#8^z] 6 !{h ٝ0jдUXXe8#U~.)m9]OtaOo4nU/FBjvIqz:;v,f;ۃV(0 {,ƪP։ ѷkw,3R8 '%1>=S5,Ӣ4v>b=u7vXnf~fk(9X#71ޱ+?{OmNBv%Gyê m`Wq8X^xsƌúVX6.{6{!cnH<]Fs4Ijӕv;%(vJ+qdşXsKpј)A5t*-RZ33f0gΜX#Bp;.!^]JFj23:ڎ{aK7n^ o&Ou:Nky?R9&e.'ë6bK߾}yG?`'Ś>G9u芧ON$8HiCZJR2IJLî8ƿU6 =) m ,HHIʠM9 GͪM"J7Hr T<S8iqvzArWr>I dAZrknql6~Af];բlC5M)F$rUd3XpΈV,anƳFzwZ.SLjڍdTnJlEFJR)I 2J+qY5N^Յ.4ۿEwL TMώy_59ЫKδh!!. ;<ŭ q6E: jg%kGy,la2U#q u^]j:Y [pLv {"bCmFy386OUu%n_xb瘜wSGmGA,|'O]%3j>S>M]f)_H|=]i:8vp8PdE1=n+o?;K\{? iS&- &taM(݊bl:GURU]ҕ OV珜 +t Wc^5qwۡZp !dgx%I6-M1'}o FΨ H`nǿӯU-R8ܫ W`=qK?tn<ݽ{L{5j)0F7#~ulk`NXӯG1jBJJJ .ɓ̜93 8j (Ƣc'"76D$1BD.Ί+ׯ:7oFQl6EEE裏P9\0FU]#t?gތuxŚjyltԉvכf :<Y&fWEϽG cTC/ٷ~-b8^HMmP4`_:Y4nxr>1}[\m#՘j,-V8^Ա"+|_n@w_6)6^k&lݳ9Eo D6+d `eU&ʹ?[_$Vo|PWlHHs1_mhZpONt SB,yw"{޾wX3%1M w~dK>BWԽl]XV~ TtlCܜ8ag̀'ng ky+$?m mR[WxNUG߾0|8L.DbRފk.C=G2_n]VoW¸6=G<݄)S%/UZNW)Zls* Z#EAdzV mvx;MS6=l4&= 4&\Ssӿ(kD0Z=AIbɇ-VZ@:@Zjϋر)t[7WP@ 8ܴ#l 4:߸ f Jݖ@S[~onilGw*QZ~ex~|gw zl%o.BRR2ii餥M[ر+cb8_6@?*2EAa>GRQ]&K5h\YV8w%p]51uA/(̧g!!wt;OCdF65xBmvlv;nǍ%Uw()?v#MwCexB 4 )I$'fЯ(#JF$Ȳ"+d\;Kfp*oF(/*cq^ZZUרunYʆou Pzc+X</=@QY!ծJ=R<=: 2%Yc: M# ){oeX9YuzmMk$IB4lv; Ql nŧf{)Pd5EW.D֤1U#91 6#M Y " 5N?Z'>ZT&{pQ `qwx39t/<-pD@@SFb"oTzvL8ݕX,9ZLΛY넦82 L~e?Z\`.Iށn#BX[Dǒ٣CD'VKNԮ703R#?O0:1ͽܜn9!n}{协){ن*Ҁ^c:6Q;ϾsB1'7K,ZKb! 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I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTb"eeQ?(/jO#ԍiQD֨5Z֨?*TTHHU֩Z֤j֭jG?(j֤H֚KUQTQ֚#ZևZ֢Z_hUVkR?I!$HI$$I $BI!$HHI$$I $WfW #? }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???\\$?? ?)tK?i?i?i??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7+PNG  IHDR0 IDATxy|TLvB  dK7T-Zܭ{om[Wn[Zw ,ʾBB! a&s̙I2!̙`h>ٞ9>}ZQ=3@B }3N%ɼVT& o+]C3<>Bhĩ,17{-º^$iB5aPDՋO"!Єt@*C}/kko(^4UCԫFh8 6y2z y<~p`Y;84!K6TIn Z%N/hI :,hhaw@+q?VQ}o s/fOS<#6b8b9ZÂ5SG-`oD^"rmG=GXЪ?t>4MsU=d,۰vn$Y"[\+qܬF"UN$۱cqq &44MC*p1xdfd$Iae?'1w-'!.YETDڠፗF @!>UA@H#0 8lAc+I ֮*j455B[?{~_=C2@脫8TUSPTE'CUTCQC^Iq3秀^m%N IU<;9g"I2=9*S*0gO6~!DyTTMa˟VX>i#dDT3IF@6ÄcH:kNM BQ_8G:5,CjkVXL%IBc4KҾ'n%SjQ6amX̴Q\h G wF\d3G3F_]>|8O5^|kͯn?ΑqwZZW(_BQTo+q@d7Z+DH1fGTc7PT!uN+q"Dax#(,9$ amqƭ9UU )n4IOO;uĩQ?D00>YsQ{xl|>3&\'&9]57f?lu<3'.z}|id(]  Kk8'܅STVkʃKU%?GVcЄFEչk8>USBc@ ܗVhUE\*N~:yclK; 2qI\M$Y]$%VrW N@]pgt +Fn^cE{; TTjhFIHr|;ۑ‘8 {=1EH{(s 07!a>_:KrRG^Pe;NehTѤjy>0]1e=.*u_8ݗ*n4MET\J^'}|I)MBa3?Ӹ|Chˎqљe]mR'bIw!= =86(C'ŕ<e%"q+TTq ɸ/Us&@*8Z~=ǘݔ4=R9dw'yMq2z{>tNLLiĤrqǛLf&!A<@SK8u_CXgE_qjg{MbMi4P>?eu1OrL u9plgBp՞$Ƶޛ{73gW\_LFU[^69Z<`Y]-Fc2b|I~aSG/ٺڶI|}w*qc$Nv;hҷQׄqiii9[q#wtaݎ76jAyh cώ3ƹBU G [ަ]v[^n8|8GZeVo_De_)++kb+af~OSVZei@-C{t~C]&{MGUU^|&ko7w\F,_(O?-) _ <,սfj~_曆wgmXH?v\U<)6Ik8˗/ܹs|g5Bk`3o͛C6lEXtN?y&[]ךF_:LP{Xi裏X~=o999w}l߾]'UٳO2ǏAkG}b,hCA|FE+?n'2n6[{}Q*++y뜻뮻G$lΝ;3fL6Kt*䌻|H $''s=4| -[bpbP$1(c{{>^ H'[+{?M F֎駟nynwS@ ʘhg['Mq_EuU999̩ 9`Sߖ{,xsQ ;9\0{4MEQ;-m?x&i%'cͬpvբLG)((hҽ];eP^Q2]I͸OJ MϙI9_q(;*{ߺu F*xmS X^2F1~H.4oQg2F㈣]rڵBJrG8bqT/ʟ7nuVSFNڧ#2|H {~#~ H|((† wKaa!o"z.?}\s& o'-8_=ׇ1T̴ڶL6IIDlL<18$I~ٓS "f^QƢ)]_o-8,[&M}K됐UWvIQ;p={t?GbH[KW4ZUU1|%+3\TEckr@X),9PцrGyK"ypI|kƾOHDLGGYU\vVr;Q+绗G|=@ a }}_]}zA;Zq,Y+ի֭Æ kZ&tjMc9Z% f'&Nu*s+7ɲ ie1}0~ӨqٳyTFj8p| @UTTE?Us/D4uW| K=fa;Dm{CI6Z4G֡ÃFUTl6;11|śm/a]of_=f!=tUSL!''LcZ`e$ G?S߄W?ITۑcx!L+B N3ShZ TK?rrrްs'ߏM(}N_?qTbl2S=}trssxpF˗3dΜ9ә1cÆ c„ r-Q@h5m@"HwէFE\̙C=@vv66XX)*o7n\On(*XM5##rIv[ ʕ+YxoU`]DIKK$V^+gS3-iAӰqL G}?׳)Z̬ʏ˗ ?O~@0cG86j*TU%=,&cn]5Q~8K;pwqF<' yVW<<I! ZoYM66$uiz4.y3 x{g~_IH#)Bsi)(z|׼:nAFGi]xx|~ #, M`,ŃH 뛍Nqw4^jNylX@ ,+/')-gΟ K&v[ dסMjH6-{:K}* xF"zu`y|k8mSRpݸ=ո=n]hf?C:Ŵe]2WIoOa]*Tθ;z x^.^*4nڹ$#K2caa7䛊D`,3]؈1qzQi<:ӭS_>NLDj<7NLܦ /}HiyݮƐqxpY% KSk(PD=$?aGfcmᶱm1mvZ[+ƮCk4I(ܘrTƃ n.;8NN6N6$'w~ך_1pPڭ?ţj*Fz͎7US"BWđ&׭S%bL~3v[@vt4y =Vg<菍0KO.yYq{QN oQQ#RwmD20iM\v]ԓ+48H.AiE?6 } ;.9m{,|]g>vld/_mے7ׄ ݻ`ہ~p氀}GNlghTn!â֌qM}>qq5P%la4%rLޭ8|b+P! P}#/]4 ֳ@BP#BaA3_v W`Wq/^:Kt܇ң]_ IfzEpP޴p*VStj?X3O0sbqی`pI H@|\2SR\Zsſ`'MZcu*{. `_>|>7а!^횂&l؅aDU39!Y8VS2q2F;u.w\(\*@H5A8z2o2b٭%Ni:YT㒘75f< _g{]s4zuT$jTȟÙ֖+K(,cJ7Cꯢ9655[M_Q/n{&,6IrUӮ][4VuNن$ti:|& .US>X&x85Tc94MS]m[ ~54MrrHO >!b%$W5_ f4a?Hp0eMp{&˿ZfYGz̬Yh׮%$$ɂ{DF }%{޴֥NHO47W᭵ި(!6jeS`USG5i5ѣG3`-[o-Iw{e'SwIf͂ղ0ܵk>f@XOT$ؓBmZT`8OԞ BIDAT3b|kCP 66dȑ>4 y6'o='LkaNnx3^}ZjDP&@7C5iTVn ȏ?O<71D5IbDyM'O8^;K8w΅?/{1!'}4 7C؈\n#j-fY]îpmdf A0|opgB[^^ >'31s5-8n8SF9? .lm:q 够@Q5S{ޛjO8,)o1$_ꯈ,D\x\yO/@{.}ua| ’v n]y㧯&E;2:+o-4 Xj>^ō+dَݦ/dNcE)8CWTH)!m:dy^|њч@[@l,)|`{|nd3t>Noý<@&anh]Tl&3ME$<&L ++^z1c .k8!S3b,ۚ"c8^"/&ar5McT>1Bz43Q Gnoݺ͛73j(k4*8kڤRZ$qt 55+Y!M94M( /?4#2V@H j***®p&BAh߶>Ahĩ W[Xk3 YD)++kr}!^ USeq1Z8 1ɠ+Gfg6s?b`(.n؂jP#4l\ILvc4kfI/fxd:^ +V`҆׻&Nsv&РEwUTMmXuFBӲ4bK.!Z fL-RԆ_y}KIF#tQU=XPoW1&phSy[-/3 qec^Є1^pI3r c FeUkBD*wm6mdZu++VHSL͈n2HLЉst_S'Zv=쵬~TcڵL2E?,NKӇ7;C{RRSY BHHhʦ9?u&w&G6O! ˜jA7mGT#-e 6n x.$)!{3fnMꈪ)-nc8ʾ攑h\dن&=i%NCt ƅU^B:?,y@|umkIP3 xm#SgAbq_HObΪM/%]^bB[ŋ,وKdYvׇ=LiBم"ևBd/R庀gu%.ϥVܞ li :>K{mm R:"4 UUf!YU\ml'՞T{.GT摂WRZ^ʳ!x+['%Rr.2VܞRѓ;'%G\lm[S6S<|\OƢU4H/ꁿiтWr$) o1ۡj ʎ5|CHl FnL@t#c,Y]A+O&wFT'klV0do~Ƙ8!TTMեj`ܐ9qY%g9M{|=o6 )9[p ) x *jĩ UePI,y6QT^ahߩKp*Xu AA^6 јZu8He3膂W!BD*L9i%O =%[)=Q͚i6P,g7-+[^eeXiSW~9_:2u{aǠ Jg' <[}m;fęu/m;h>.\*e㮷-)׏:#1?y$I@VD6C_ h YQU%[Rf0P။Ȉ_<%qPjɝmڣ>](fZš6jGgX+y9$f&=B|n-:]U0QTzHB˼<֢]rgX4MB噈ʚ7!$ǧx)-/!Р)xwyy}*j WB#́q0Iɉ>5W&) &XM_eFxiORRf8a~"2J BSz+D/񵄙轢a{1X٤rƐ>Ym1\vUgN4)h(;nڱw{ZTzOOQS̊Ox}n Je.6yN}mEG`A@Ι5m%ٓEQRdi5һ Fd*ʚ%O{Dq}z4mgL^R#t0R;H CѵSo6z3%7LNx}neWM#`88@< ѧ׳&QitKq᪾<YߤrfNn2B|z[K"OwiZ?y1k}޹Z&Э3 -sټi9C9RXaYHw3RžnùfOZb5}{"I2^KUdM.kΤ{%Eq$x–^rþKO ;SIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ??9*b"eeQ?(/jO#ԍiQD֨5Z֨?jhhT֩R*TQԏUZխHEBԏ]iV*"#j#[ZOTQTkKj֭jGI$$I $BI!$HI$$II $BI!$WWfWW #J }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???\\$??3@@8@B?I?I?I??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8+PNG  IHDR0 IDATxyչgudW@qCq}s]0Ƭoson,fAo4wCѸoŽþ kUSU=3댚)zݿzs@E;|&t'맍7!HO.4klɨSO4 gߊK9wׁnu@ۙNsp$eZX^e}8YmQRu4@#ӻ)* K)QZHCfݧcҴǖ^U9vԛ5f$fV'Q%I^^( gm/rO{Qۘ]ph^^(m #sQS9,, R^UODq"ۢ |ce˴V_֍sǣ\@ޮ o굞E}tkm>B#jM= >{^mOwgEʒ}ߪLzJE\>[d5ЂYo-kqȩӯ=zHa.\z4OdOOQa(eYiAR&)+d=%v_J>w~o#p8#ej|Y_!,ˌ,^OqکHꚱ'Nϱ g/$c_U2}ssS.S:q}фy(+p9 ?Bm1tMiI5O'ִ?:Whr;(<*yԘL M"?v Z"cLj;)҂01P{i#X~izt}1{xS4Y8FND'iG1c 7 Q8 bionLj#%ȡ\"- }N*@]1E! eJBi i]kmF-ؖeqrل]6`>o>G]Q;.qQ2W+̻V5)%kw6t݋{BPubqVИ?V57!#jBhh3eQ0$~$!t+54M* V- fr}2E]TڀJAG$:6г/ \ÛӹjYEjB܉נ SMK N%0 H%~@cߑ-l߻4(,uф=n]p/2?p~yGe){\HiB'/P,ѓ[4ݭzΟtGrLKћ#ջ }zZ=X Zɾ#[Є..^5Fqa/<K;/9f'0-$bIBhMCӒ#% $l۳5qᯝuMZո|<*~̞Û0 ;eN1-Օ߸~>@0HzA4,i sާJ5cr: O$&l0'e @}NWR0-ₒՖhbIp$av$NGX9 ^HdcHiawEkBbI#J 2@|mj%I*8mYD !4O䴀SKĉ&!bLȣi:HRUw<ûkM0 dQy`C/Ч}f=;ĐqΣ̜zcΖ ϛJp$H8$waF91S{RbaU)ߞ2nzǻd9u[CRʿ`YQ2|:|.yB@-u4kҜ7Z0"3w5걤a/:VafƮR臮V˞y?O~֘N4F0,$ %YBM]a.s V ң9POqA)CKJL8ScLǜ3rO6‚MÊ ECT;?l0Cy-ia\-ѻd*b[sBS^6e`Y& .vR~L=҈au7G%$ 6n7y& G$jIA!)]ەOM0)N8N~x2,]QZ^6E}GI0'nVfӒsBiê/ 3?oM)*OXQwİ2#Nn"_aرlToPnGt('VQ0aQ&G)vjao `ܩ Hs//Oee~&RZ--k~IX%l {S ;^=-"QF~ϓivYqՌ{C]ӷ"L$H0'NmI8ђNg}kw3p)0~K{w fN]B,-mMb4Myk:).ϓGC󉔪qDTv~^y6 )x9dyرo-l6qnj*g0-Iypd<ܢۼ8hYP6p4>o>=cQ=ڙn.MÈIJk/?si&%q Jz43*}u^ #T T40M^=aIK =&-PSZcm8JmQ?MMD#Օ̻NVo~6W^W\.=TÀ>2#n5wi^a:C:TFƖ*fȑAH>߶0'^S9T#||e"F0"v%&&ix<>mo5fm,vrj'eNMH%rjWϸUn{۶mW^̜9իWǽW^6޽Q(Hv9>1 M5qGBeuGxtА@$=U#d\S()غ*Ο|HQ2yy#9Sy֖S 7O~#/Iz2vaOcicXxw1B)6U۷t>_!8aN$B}S 7VSXDN9\Í/'\H)Ya)w-XnoU1`@ƵVL2_.O'ȒH"#t'UD̐l`M/1Ⲹ9gz /R^^3apG:JNj!- )tΤ3]*qڃaD()VLϸ~N۫NW^y `„ ҅`׋gAg + 痪F49o|7pj'ۂGƼyrw~^3_{I6;87_C@| vͨ+*$et%EmQ {vX{ B<&O4"sҠ1nl!t͹O%}UҎE8eGY`8+dCU;ф?`Z&m,cS2$Da#H(u$&4O~}7,C1|،+cKjT⫯~Ʒ TT5q+>s؎VivGDw`9RNدt"XI iзo_&L+)%>_egPy =sOFKIΟ8EU/Ҝ<ce4]ykc%O'bm"&mOHͻ?h9њ=~&eC(ˠ9P:k&o|CRT?@0lv'KDPsA,L {FKI7'?Rtmӈ#G;m6+3YY_Ax<>@146huέ_o4 3Tq`Pmf$#i܍eIĎГ)ޖA}JѽIOtqzN~MUEj)gϓ\~{p X*^Eav$c4|_!eMm-Pr4uZ7ZUMGR!p|MGt`ǖ-\JR"K sIQȆgqCTo\+R^q6xD@\K$BJfi>c^o~tʘPTW{ڭ|HHGIiq?zHTе@ghPJ^[zfԙno,  ã{4yF ˞R-@trec Kt}F}hB#&khp$_vs޼yy?soPUL *eɒ%q:`it_T [}'@ -I3*njI MX+ ";Hj7 8w5nD2ظ.$w/p)SR :gy@~=/Uo'^/v_8TG ́c/bKcgu/K iXd? '4k`e<'2g\v I,ib%}J}pW1.]ʏ+I*Rv|tu ]]N3ulȚtDh .bIaؠ1*i# -YLab2?O?%PEbxUlquq-ZaܹNu'ݧ.NV=v^(FL=}յ9p4uF~TImIUC꺩j鼘H!en6~?O?zGtSb:2p\6^ˋ/wqR%MMM=N s00kpf"KXD&%::9̅v64|"*)rڸ]Ko޼7Nsݸq#7t[xP{(xى*E3?[F9?J\xu^oBKICq47p (m^)_қ4<By |:H$fHdSFZ](q5!6 '`EXL s)XiMwebA|_{K BH;Nm"f4$z pGcP߃u>$oW^v>o> FVmzb}Y߻hQ#abkc DK8dg h:ʒ!z nٰmK0L]c h40鴋,)&4BaF;Ĵ.f"ɢ>%̓(e4R.To}KSS׺(AeXg5w-9oK=F{Ɩ(T?zS~.h0#2~ 6lI!0p֥M,Q{{.-;Tc_EϨwvWIń[S>qS7SQ>.hș.L#wswtOg@Ɵ0~ԅx=yjMWhnXǤIϧC0^VYk'|~۔?kA^1nKИ`}Kѽc8_ R{(1MSU!p8a>|b9/RYYɊ v=MPAfo~aܼq!(:>~.kM;;I035_)bTcH6Pt|>L믿˲Cay WI;=j$~58tڴiL8ŋYv6l/᯻'`n|EeeZxG AV$Rj,wou| lbzuk:&6o R|'#TȀ+Tܽ ^~G: ?/矇͛a K%`ןO~O%{kIXQ~/`i [α+O~(/IxO'2@p‡[_59 c*p̜zzm?ڜ9sٳgl)b3U3Hn{ox BΓ8 k55zEw駜kWH.LmXR l5à(>N=i2ݧrtn^3:ݘhl9p{_utrHd6O$Q\iZ}G>@Ͳ8-,4i!f{0vlTe;5g7' [o*MlڵM^Z".qQ'xy y?}.wkTfl:5x{S+qR񆷇3g2zh~n4 ׯ~enŜHu`}'xEESXX7̢E7`V$BCa!=k8V/^LWZLYR⤅%%4! LRXyURzn\{xycl۳2Nz>> wot`qO׏o 3FMj}rqbuRr2Bt̓u+M=׽cSEđwbfRX{xlذL4.nx+Yݟ! Fy܉S4#V4ԾX 'شkyVJǞ=  oO9 .^sUëlXL; w$42΀Cd&N7B7qӍMnnt#-ti8H FZ&N7B7qӍMnnt#-ti8H FZ&N7B7qӍMnnt#-tiU@QIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9說b"eeQ?(/jO#ԍi*#T(WQ*#֩ևևZj#ZZ֨?_Z#Zk/TEDDQDZkkTiZj#ZiUZխH $BI!$HI$$I $BI I!$HI$$WWfWW#?* }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???^^$??`;.@7`;>?`?`?`??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9i-PNG  IHDR0 IDATxyչg_AdQA`%Q1.YI11&&xMfoxM\E#">0{/UTUW=tOWթS]zs9#IW} a:i"?o~sDx@B44em N46 kwדl}P W7!~n܀aNa:W\r'\=u?D"1x{Ûu>{8Uqŗ}`o_O#' loތh!4 !4Ŋu8BZ ף$INJ%crmAgwי> Pi @JoD pܾCp_2`%B z(H]̝v3M5h0%B !v#t\ a0cK  z T֔R]Jr2hxϢ1{ ̹37VaJ4i fc C)%6^=X10-SPz%UOChCLi0o;hu3MK.X̗n/gY@U)ʜ wc؟M6z}!C'ɛ+m? ?ptD_}c%n9(x޻638E'(S]Xq~n?8]}&_-Xʯ-%ZJ9"Ɯ;cZGt w0M&L@uJz["QY[B,$MWJQOINCYsDcOȉ. bZ䑦) l+7"o9;m٢U<)k$]}=H$os)MPBXI}=y8[^yCS5YyU@Wǜ?c0gk^ /̓y]*.ཏB:_B(=(z|ه˹ዷd۾U.w{g¨K䭏^yN`bZ:EM1SHmKgA;  {kf|PXFLöhOWw>7)$H}ƒZqOf%P|un>۔Ӳ ~ Icf!,smS}r*1hƣWԜ)}dRJ̸= 3d}rOsdc?kY3(>a?4h eSt]%)QccPxi(;@}QKdKAH _80WԜg%l޳"=4ͣ$!nOoQ(-?y(9}в'Ǚ0R_٭jaLo+zw f?(^O^O2' DqY!4&id@#$-_:=-pH#%E?:NK;@Jȟ(=,Z[ۃ8&Ӛș*866I'$*cCbJ oġq u\HfJҚhGJShBX4\/ 69g.ȿ[X8k9Rl/㝣A:8geNJ'I;,_WMEbh.4Ywblpwg?Rx4,hsھ[ 勳wd6-s8)9` M-~i\3;|]>bζCxwhI7!4R `3nEǷr?wIO<X#}G7 .q!zS~?cvfE^>ʐc42^f"Hi +־f30)i?@;}Dr%g5 (4]iIR3+d7-~ȉG_)TI2Ieϻlڳ=:%#%;;E3 ^WJ/C&kڳO8}?x|3^rK6jIIj}-qlMMc=`Sژ=KڄSZ'VL!C̙zRJ))?إshu;p-mzͨYSCJ?LCb}‰B+ OWsy#j3|`Uk$'*%5c IZk=.䯫~䒲aes0; ç2}5 9q?1BhjUOoR¢+Њja@H ְa1x ! }0i$#/{0Yyւv\[ (8:a6bmۿ M(K:9!\"[6R v -,Y.+=шmkwt#&3-ײ37aPXEn r3G;#?p*PevH&tI{,jҘY  `lFJ`CH/U`̰VsqOvJXÔ6GY܌""ouRIcf[SSG)M*H !LLeUǬ:)x Md.ڬ1,gl҄ cQY[6q[l4+BZSWg$X^RְdZMUMCGh.SY[b{zHN!L xbG:9V^+%ζ!.cZ^4Dz>X="n_ . S'^oxڛ4f6KP!FMi5{$Rhyĩk,sB`h/=Ě@V̫$X<>ZVם_9؂}*0cOU?(pw㳝nߔA=@M}9em7V^s<+c.zn_{[?<1o:*Jw[S'i8MmC9a@.Dx$X2Dž:Koc)e6Y=o;J'`~isj꺓83LJ#[a(.+$5e6STʞYHA _Jl'Qh~5VTMH%:{ Yɖ+'V&)%Gxxvئ#;W4Ud;hh&Rc#>@r gt؎@igE 1f6[dޕ!”&&aݦoi\|UԔ!<u602#<)0B.pE1IӠ'cZ $];'.6R_->3B]C6wHa|3k+*=5 6h|;+;y'Ϲ.#]J"Т#JIJsfi& }Fu۱c6=^&N;Ye8_”eZa̹4\khn5X2uB!?AGt7;,N^}"MQ8w[^> 1dq_ڬ);Of_JY~f!C^ALi2n]t`_UgsԾ/U-҄'mF Rm W>`0s,ga|ogs8V.0 `Kdgiqq1~ξw㴾'b!CwtG;Ӧ7bRUjo@KA;ڒ\sLqe0Cls_4LFV\C';ñqK~~>\pkIzZ6L}wWϼ!jw͆ 3 R%[WHPʱbRH@o1imrIa9Nb:sA]7X2gi9Vnn1y/'\PFd߼S 4Ay#>7^w8>4~-iPQӶhtf9CcCu.{SJYH%` V`"pukOSS 7!rr㡇XƊ{lprNUŰr5t8r6"K,R=`K_19SÔf[W!]w)TPnEY|++Lx1pY ED4GVFٙh׷ lӵtx}4Mg &RS20/g/ !(*݅[՘J>MgϞ&/"['}bf̺U !ZJIYq 3NJ]PL |@zj2]r+TJ7*[": )XJSn96V[뾫V*HIB2βJ2mZHBee% ׿mޕLxbbhԔ E}#dXD ,ֻ'ncl)"%,INJqJ;Jq9Bmf콻{C߲(_n-o s8Aӟ'%~~niXRmsX7i㿻G?fM)~VJtKwO[ߓ&s+EgzZ7!MCvrDw*I:(NVpu̪ӣuΘI1Py/!_`Jh^3ST;h"V\I]]G=&LK(%%Trh7} m6:"׾)4!|zT"$oJt)jt=RZiNyo Ӳ_QȓNãP6446ElEEEx,]r]Uֆ[ωogܰ)Tݴ ofQi)YaIl7Uu'+Q+d9d2*M(52bI!-cyQ=ʪSi $o*R(ߐ&[98۪?nބȉ6;=K aժU۷wjTuJ 7Vikwt.+yw1< !4t\_kMzogb }܍i-yٲF((9}Mt4K,2:Bc.5ܱ[H)).g;wbֶH;TWu8g8r@L]F9՛ 'x, Y xy饗zxWyxoKM{V_\H)9Uq+9|_W^y;ֻ])m%PS!4މ{/~kx?**G)حcoe iP]c>aBƴLd';ĉ_DFXb>M9_Oe\w"EDְw'Òǐ!k2%'VJջA:c cK{ 'Ah ?ɩ>tT _=j*?mֲ]ǺOq&OʤRĒ0]Q,6wӁ;|SΛ~+*ϑpa燪|RRX^"HGpnBp+cϺ|uU^7@ xѧ%Ηe Xl~v^k `W旿l{1v=Y ~>Kz_|eX__O,,EҦ!(,,mҘYV$U b8x! ;%sI45*Vh1wSM#2~` 7՘R|GZt)oYq̟~3~d>*ͪgvGa)sͬ,}A=@CsZ'\sXJގս v&-L Çc=*VwS>)U+0eoKq}%s3.Nc3du&=+370(>@0lCmWκ/_mfΜɆ Vއ:0+ $IDATubsSL`1=:wgѫĹYzCVq>(V!]D1U8?aR]mφICp]p؃J ]TWCw=[4 /O~%m\{RKj+m(GQ:^qՁNi){pTir?0XƎ2$ǫ)(fhFeN8C}}=7w\Y7y ׿u﨡`8 !<4;)AwGKs$8{:;dpH¤Ip5PZ ; R\VRSSy{wӤ`II>s=;Na\|mlnqSƫJ+ F4D&e0ySbxj<<>?:iiiL@g?~L0r)l}զ:wR {%\|\V !Ǹ%M{Rg_ҿ"xO~LZZ/;I&%u6vp_Wlڴ)"E[w1dR%0mU %oǁsW ?q䉆7ּě7OB(~<{凄t_GF9p)PYY믿F+ %[B9\qurڵ4 "k~'0AFkZ+Aab&h ۭw]͋ycU!۸qcdQL!7U/^u*'/byk19K$΂;NR\=$'Hj*|p= %%BeLm ҃|U==n%NWw cwA^#q8 +=]4SQ{C&!୵j9cH)Y??~I#6m4W3h#{9d]7?dEe%Ww/tFgU6 [~gJϳHHem)mwşA6a s6 R2VE&_˯>K}cםx$}(fę760 @vc~|HLᠶ VII*}u*^|o@1tQ"ywfL˧Bv"MPY}Wr2&wf_= MT֖R\wҀjGҀyNW$Ii14g TԔ[BXM̛~ B <?!4e&/RS2IMN'?tg5[)8A̝v3Ru?z(/Є5Z_LGn@2sHM ɛię;mY0 RQSŽK,̹x X 346M7f $%9t@' "ii l^7X\63血JkƔG7CfZYyd#59tib]5]&9" PYwm_|-l"hVR9\'0x<2MrRIix4/ڈ{s%wnUu' ͼ2t&F+~FK0d4ޏ\2rIIJ#ɛB'Ĺfr2rjʝe=ł;> tjs4c #-,RHO"ɫu87.}TԜpL}̺)%|fC-}gLSIKh8"i)`3MUTח$OnxЄ=_߀_oh:+ezDž-ݾ0 0AG@4Q]_FeIvGo_£yhWzP,ib oZJ::]46PpG? )M 4jo:K8{8Y+ Bf]\MCs ASzQ쪯i 5VRPާiX.8 !MS{{om櫾FFZ JO\sIwD]{V]U2rIMNW 6TCe])U'8pg s\6Y4hQY[BeM)E;nS 6%}8w/y;Tݱq3#F lYK(> H$y#5AsՏ94A2ʫ?u1]Au]YѧJG@쫧UE>ʋ5j~>1Tݽd4CRQVUDY1DN{8w.4AU$7q+'+C՝EVz^oAݏ/HmC9TԖ jۮ! $TܽI2 駡b*jNphKEEMZjP[hjK-aYR&`+q9Ȯ:$;p,'EQZq$%Χ-U˦ BYUQ:KO9ZJ)Ǥݳ9cOǠͳ3^?> Ms?y!^nuv:`;ɖruV[gs&Ɲorggs=˒Uut#nAqdfouPT}EŲPIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9ꪪb"eeQ)*# ZH#Zk)ZQDkWQQDRևևZj#ZZ֨?_Z#Zk/TEDDQDZkkTiZj#ZiUZխH $BI!$HI$$I $BI I!$HI$$W#ꪪ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???SjbS$??Ġ@>+@rD?.}?.}?.}??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10""PNG  IHDR0 IDATxy|ՕU՛,Yd*66 l; 2^^&LBC& Vc NW0^tvZ{>juNUs=\IQ7$̴| MS}pq >.u=@dYAYAe$YAddYA2_xM6Id$QWo0eiA7PqiˑeI#+(& HdIMU>Id:ab.#IdQu5`VbE1H0Gy^AQB|jRV9i 8j!TUEBhG>*!! EXR0])vOVZAD TA \$(QCXbO?;DNGO@x:B`YR^^3hBL*F!M63T.&yDG58AuCT5ԁ,ty!ӪʎHHfk4jU}8B@0G'J g IR蕌∨~Z8zza,뵍g3y<$ \NNEv ԣaUWBhLͣk C-* cGi LՓn̚&44M壣,I5=J ZݡgjI4?'w @aH@Vz2I Hф@B~pHA"O06(AH<XF_[62QR8 ]dh SJ\# I2!5*4 \8dK˒0mbB4dINگ,oUBBE?TU 9zd*-sظ٨N.-i:2RlB=7.HkпJ g/:R~6 ZBjA[ RU&0ixË',R'9X_n}Y[kI֧s.!e7NÍl$'0a\}E.F&eEƾcM-@ §rTbJK.UͭOEU"3-.Mg&:>c^i-5S+6Lȟ,?!26h"dhٮ i!PDBl,is|ZNiۍ/xc˓Q߰Ic=_'Rg"daGx %A@]$H4Mп-ϲ2ɣA4Є4CITMͿQFEdegEo:GFje,[ZIYckk]QND Y$#̄4j 봔$Ylt6 6;a>n(f}i ]<ٺceM0.1C'vt+ DN|?E};vDcy7likW&4tr&P\Ȓ= ;ϲS2c:6 Ͳ8;6@B!w+ p/[ W~_7~NC4]؆(ӊf-yw !%ðvp(8vKFmVbX$"Z?QXBp{O*+R \ϭרoJyӒDzrAړܮDkY?XV/uq^vn/519n[FihgZY fdo?AT.@j$x͖ g<.ixf+1|K6IE%B7D$tHeCcK-xDy L`bVbð7~LDfJn׳DŽǕd]|8Xᘣ%`r"l^"?{q4ԉZ-"֬I9e'I4eN 5ʋ#,!cU)q'ѮCdKB\gtrP6v $ʒK,tqdjg_u\^VTI,K~y$%+?YP^TRHKζcMSs7ya>:ֆ\N-BB2ȡ 4+F[M5*WNyQ2xPW/I }7*Bo-~L{$ASEr8\̪XUv-̞fÅǕ4lB_;Ą\N7. Ӊ,F6vUA," ep!4URӃ֫ t(+bzYuѿzU_0%[ B@z74aN;0%DhX dۚ~EqX"8՗Cqt;N3Hhcj}#ϼdԫ,jjh@a-* ̚# qݢ#\. 䉤P[[_ly VVF8\~3'-faAPu<ε'Ilr AfZR6ޢb\Z6IMΊo ,b^º8m/.D 80/AiCUu my,[p±Sк#Η_Aǁ F3򍘑P|A: ] ѿ1 dMGYN ÃFliN!ӯ&91cY*] ^/."|uŽNH]b}6'2^*&=%'"[= hh:Nprx:D,$ŠnOMM9SLܮVj8))3b:$~:?lL ˡ]16ɗǛH]xZpl >~$G4<ǰ8t|{IMF17-S qL,ss؏A"AuUpDO ,<?o,]p'aWqfLP#3"\r ^ -zc;?ı IBXI0ݮD+,$jj,{@.N:h˚hZ;e!#f]oى˙@bBAd)$&X{͉/$$鯲ϝl #Px9My]@Jb"?z:&XA^v)W"[Otyސ=ʊfP8$liDO x\I Mr>7Ρͩe(*i#/ `e1K$'Qoom{]^'޷'MC0觵 m'F"S $'32$Iُhl ?"65Fu$9m)u)1#wwf 9Wws,_Ԩkʙ`#a1QVTeBNI;I'aT'lɦ͉6ݓ{r\;i&~瑫/<Ro[ ٸ^&"ͦk#͞Í3FıCB1t L;wnwKi٘Pclg馛())?nw]Eᥗ^g;HOGZr6{7mcnN2&Z8S{G0rNcd 4SGq\2OO8p; %q'q%v%eK{CkjcYp!u)_W,2iF>HRڏ/?Sy@-m \l8EZrG+F$4`(@ }1Q^<E6;; 3+Ȏv atƒL-y#HAGnk%lZGO8̪XdܫL(ƖZ<Sq!BjH79P^\mB. 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I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9b"eeQ?(/jO#ԍiQD֨5Z֨?jhhEGQDR?EHUZԏZTQ/HZ5֗j""?֨?5GEEF֪j֤BI!$HI$$I $BI!$$HI$$IWf# }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???U-%U$??@b:@s8 RB?@̶?@̶?@̶??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12#PNG  IHDR0 IDATxyTՙzY[YZ AЀF1,L2|Ό3W1:&ƨ[D$  (NMwz=[UԏOQU=T>9yHN\5vB&F 㻨?iH)D0H#zii\;TZJ{>lqW'.mJ?xz(ԝ'Fc7)ŕ-9T~ FiI}ʧ80-irR'YMW`{gwk_Ž8PoMl~PZ\..3!/&BhG7_W>_kLn(i6}-;W"X=?C yw7938=w+'R<<I`I 9R8Aͮٶ{bY~Ɯ$8:0iD1N4bY4ȣ=:uc&Y$Kp4lc=f؆3]0'x9\;05A:4eaX7)=Z^yz= P?MP&kw#)ۗ6W\5H^k7i0 n?#I^⾾yC ?x)ɮ4tqGq8~{=M:f%ɕ [3NHYvU&Dדe[ W]*OgsSOeE=e?l?[@CS{v^gOH S#OᖐZ\JIEYNYKӷbKĭd"}Ԓ )%ܲm\Xɡc;mxq̗/$\@ c1 wݼq[ѯ:MzOj_pn{u/*Hc&RtMG׽hBp¨acZ&HKy$L/7kr< M2 XP| tݽM~/wr5$@kj畑$BR1m͟~8KKe@(ZQز}bjDp%-i溋-JK{?ok~i~9&N*4d BCV3ݏtM獽Ct58pN݊:,Tt=HiQ{`|EaG6IA2&x:{?’87^~o' f) %77J6CZ(DӴ"@8 X&:EJICIRJ4NreE8tc+u2iY^U0ЏuOh #`ߑmHiq 2 XkfJ@9A r*m^YAnA dbιD=0iF!GiXhh|WbvM> АȜOe!,BI851 8TKQ_G?EY:FNA4'/*^@bMWHtݗ)BM"l=z9~RjcM]k: s8 _>~gЫW#i">1̘:7[EwgLtW{a)H MW5#{غ+v[R"10cbN4p_nrx<%NG*HI͖:ż[Q7_5ӈa~3zWl:FXMVd%U0 $KmWҳ'7ẩhgCлb ~_aZ&1#B̈>1e|R-SxhM8Hq"3bqB0},L? N=-r,i3Č(X(:&@_ OT;E2%haW)ΞS/2RZ<ڿvɸ~3ebQb"MC7LM~?Мa!rman݋H)1͸;Ǯ5; Y(c;jC PA,& 6 7t;i0hBsNq2Aх@f3߮X`y7eo3)-{I0x! / e !ԴSgU)*{ë1# ˄#o[F} ;R "LVKa"_4!4Mپr >Lhh*|A I8KIƨ=0Ԇv|WzSuIv̥0BbFMh4 M,:}S/8׏i9knR~yw3z9n"(,bPm*wbYaY+_}i]!P1a{FIӷי1qez,3[}idQχ q͐Xbi .QĉP0vd~uk&} ӴA(44պфnOS<{`SG90]RSI{xasuC ėB`јMC/oH&`|?|76Ih究CFU1ƒ4嫤I/$j>L:{?aQ?͋iIk{ 1M.2 t]Glc]p46 # Ԟ8H8ԡ,K{@bP|i]_;aū8% s ) eR@p7ZgE4|tĸqf4RJ‡aism7ӈr7mŋy9zluJȮeivy [ˋ/~1rEn̖lCvP_rmٺsm߼(H GxǸ=z4UUU;v,5>4Y7v|$zAE;,iKl45)^:n'ߎi8p͛73|.kΜ9l߾zϱcL4 :f􆉏Cg<:F S7X~=ƍ9sWxuƌxi: iRa6,ᕗe%(X] f DGѽѺdg.931c$}6~xCC=$.\VskZ_xqű/Z^pUm7v. nj#͛'"Gueqz8y'>o@Keiq(#{W ͸J3!r: YVիWsW̜9sXf }aۗ2c,{GII cʕ_҄^SSz'V8eך#Mل[ĶϐR2o_?}-…1P^}[3G$MȴΛr+q귤u]`8իYvmZ;eٲem;pM7flqیC՛ReaQjjj8q"y aZ&k6ѢH4hBMݙ8pTUUi&~mC_ kR0} |$;m5[{4.;޽{ٲ%~S5s!o 8Ѓ}h4chBW/)J;8o8֭7HdoVvBoUO+Gfml͡Ljwuժ6tl\d$*ťŕHJ)qF]`eiI89ž:0:JyB*δ424G?smfH$D4I{<؈Y >ƍ7H(⭷ʼ1" +ATyDE$~*]'j:GKRZvtEvqޠ3?e1)~lhsv0ʿ hQBES `$J3&+>c}84Ks+9[>ձm-ZLI4Hyf֬Y}שay=~5M>wdDοDR٣_p8~893ˬZÇgcHǏyT4 xA7)+{¹38酩*#Fo$JR&֭[G `̘1L߸}~Ntkըog4N)IӢ+[)<" )Vb}?j~jO]raŊ\zYiF֭j/J`/p0穪1x=4vFMO P[w2ZiN֪g:5fMxtBhI}{X8?P4NbҮBҳ6pL+%BJ 0-) TEJw qRwU9EsV~g~ow28LAB$B$Q>g#3ܾѬ=TWW? p Pi+ICC1 K Ie˸2~<ӻzƖ@g.kK;:-Cvl;S6UMMLrFa~fQ ]xq̞=gQJСC4y2vߏ裡}N|][[KYYfĉmwc8T*q3*4ZiK~N3qDFSO=Cgg/o'~]\'SJ b xbNqگnEt4&MbРAh~.%{U %[v3p.ę6 "@g#FHV}i$)$˜[:Yrę<ի 5^u~ab2^dϧS 6\?y.48N[v歮B޺fJ!b ,ncᢋ + ձti,;*'i_sͥgm[.;odHϵ Se`?| pI_\ : pe>,΁Gsi̟~twMˍUwB}W~ZeHq{' .4ؽ6mqJӑgŊmG6Cu/ڙ'D At]pJ5l3gQ[k0zT)77|3guYG ♷{ۤiIl"a|P ⥗^b^V^^׾YO &T\SEQww{`-ݷ}wy'֭K:mܹs9TVV}vvܩ/GsFI>۷ưzcw;vs xW/eayspSvҥK|׳}Uh;aW%ǏΑy}+_r%P5 ʆ%_oԩ>zrY9xo_nF)M,8re SNb3 o W\lݙ|<OVTE"%g('Kky׻]]֝k:n]e}^ J >qAWA fScR1uF%P5be4$ń  NU0 ] {3c꼤҉Zc%fDYk L?A%GgĈʂriOqn\8e*'vlr%065eTkj ʹLPjBI{bLq @@8$>Ѻ|m^v;$&N,==D"M44rIDATnjv_m pUmB_XƇ< Gh#WҾ6en^Ꚏ&TyDISʸi j}v]"H'n nfYɂnJ PQ֗=T5)-eۮ75!PʵS)OYJx*ѽx^4Mò,LTIJL;I 9tlk7,˙OQA}GPVғ=,eG/DYE34ṵL,u*D8Ylyr?M$LJNj4 bFh4L($:ACZ>~zMM>|*RZTAIQ9q;#,,.{4c#>Ki%H( uq=TE^ےn(Hc).8s!*հ%/y9IZG^'խ@8dq  ) #S@F(P N@2B8dq  ) #S@F(P N@2B8dU?IENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9ꪪb"eeQ?(/jO#ԍiQD֨"QREJETCCR?EHUZԏZTQ/HZ5֗j""?֨?5GEEF֪j֤BI!$HI$$I $BI!$$HI$$IWfW#I }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???``$??@ 4@ @v??\j?\j?\j??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13/PNG  IHDR0 IDATxyTՙ+45 (;bT"(I&1Θd&4N$:3qK⌉4QP- (.,t7M7V۽|ܥiUusNUsy 9ǐ?rlf Jw3v7z&Hu7>z"a;Z`qot5a7^ckxGWX{= #D~fߘCh"(g>Jic)t5)RG:.-kIBAA.ORGtm)uE1 Hi)m!HH)u-kIpN&!VՕQ]_PfM^E#M{I |TJۙr/#Te3f M#gM^nNppݒW$IYsӶ%H_k̾`Yv>%'PY].{>]ף:p jm,H${u ]i429A:ۥX{mK=A"ѥFH R]#%fb"wf݉ۯ!q$RCn_*P<=y)88p'm^=7wnw@x=Ydysq<|^~>[`}ϞfUUEC|ܛBrT!'NA @ z6~=:DBJjOYMWQ AՏ Sr)%Ӭ`>ǘ:R2)h88̆B~|m A!?S_5C9fdxCn,tM :BsF)}NMU#P)QCWGyN" 7 o6\®GN⩫Х 4#D2BAQpSn_~|W&98U)lVGR(!'E'$ ImwDّ#XEq ㏢C]s%~^#VrARSg¨1!\R~ ǝE7́ct`3ca iaG䫏r>!Xp}SkL\#hƼ+;OH R>Թ`N1ng_{9؟IH QU]T9e1<ڑ蔟.ty}ue`юN kajXçbi}㞫mZ6M0<./wm}7cp㴴 &**g ҒxwNMU{3YQ)B2m}Z'lI)d!S^}H)y{illLx91UEG)a^aHXPKZj;w^\7^onGSx?q0X9c, RŁCqt.FBZMSѥ>3m@C>T-kFщj(aDY/8N;t MW4fN#4M3 i!5HH 4K''1h}Is$T5Ās aVQR7!Û-#jC~!"|4! ӛK';17FU!P1æt[Mt=q$Y+8Pp(ћF]W| {ˁ(8@CZx( ;/$H:nkhZ(7ԍR$%9gX1ÿ=V&ɄQ3sEU4@pbie h7 M@7;154U!N(H:@`8+-ʅ_P8r:9EI=M߈!եSqdveĽFi+b)efJ/:gF`Ҙ9*6mTT҂ ZT?@@HPʼnCqqerɱRo4=tSw6ᜏx8 4 AEXlNTho@"b?%ݣ?hXZCjMWmkthl5L3"ڃ͐RRPag>Y'8B;l2ܩDVTG#R7lZE8P Tp:8.;!֮EXa!4',tC' '‚齢`M5M(JjO04li*e-ڳ&LWXN^ize;agA wUxV'믱0j$da]^~xc1  ѥ"0᤾p@+4"jb_%?RJQ签; }TH`̸` )8^q]\WH U3tM}!4сF2lt৽fZNTMEBƽes@JrS;JҾvs<0rDj*p(#*7;IARPSDgh H}rzp(ETV<M)ap1JCNמt 'r]%4%{9 qOU3>ƍ$yJƖj*i7P::C}G_ۣ4˶KEBĚ7CO0b"߻w領n!m}Uں8Nj#AP'NFJFܤ4v\Gʑcڭ*>"ߺm鵂c2ⷶټ⋬]65QPM ؒK'YXܒ3VTKI06W m`QyD⪫J*ţ#8y@!.~mɪ %mF8w0n_#P[v!m8p _e}}f ;et1qWINQQUЁ>֯W6kNX&lYY]QZqDۍB^)Ѵv8q=3Sga-ET󂪺1cәFйafbtp1^$8V@4}4qr)B]DdeF%†§ Ӧ_#! pmM7APB>CR2lOCsu/дAgI "hEKd / \$K k5D u|jP7:h6w5Σԑt3rmo&xACFXrPo kgؑ~g:4Mkc>H 8aS; ,⾖L;Mؾ un0苎F.u[Bwo>P5Lv c*Na:L:Fkwegp,C eA9B5hE e?Iu}9eƭ:~۵KgɀAeMۀ3 )+2HG<3 K/rowl_ o6RҨpEU1&s^p3 8FNO[EX#c4GU̞|%{_&4~@p3>:pЕ g%˛4ꩩ+ZS9)-wpͷW^߽sihtq4q/DQZ;_#5u'Y6GKmۏAArtzp;\^~}׮pp$7⢄ʹqe0a |f>;VmL_*c~K|s݃O7Ͻ $8Z苪>nz9B0p1aLCv2 An&Ûp1gJ4=o~rF_4k<_GJoהC{`XXz 2X-#oaήG~r9S7݊5C;NdOrrzpgugpp8\(B}&$l kjgHX4FP^Uf5erMp)hFu]{C\ GNg̙r%5AK`ox0̳ÿ%$ͦ.3˸f|f1k,̑#Gmh|&BZMF6)u.7#O`vj*n N|Ƹ2%v|#Jx}J.q> ) 'Cq5kLMPHL:+.ZJ}vm̝;b H+s@ ~BdhT1`jc54f$j+?Ieu1M-WP]46쫷s`p1[k_Uϛ1&SQ]l0' tf_=[, bzfca=`ySE᭷⭷;E^{M3p}mÑL+ 2ug\cѯPB!?2RNzcdQ")5Mٛb2jH#_\9r Rr. OX>?9qYU7nt]K(4Ѝp%[:W- a-p1_߾ފg@SRZZԸ!vڶ-D0䋪T/p:CNP~f$r-`QDVf?QBG:"yQ(z^hҞ=SJ[|?%ݝlfX5uZU{ӵ+x:Q)ŭG4NQ nK=R#l!&>~a}4|ü)+2 mLEG b,dDܔ%0TORjoD C /IhsSZiQD7i|ٴiSB7{ MSm:t1*mz.)?]@Yvۮ'Aܼnx99ߎ||a3i׊+j*^~95˹kx衇x/իۜo0l> w:ܨ&8G4[.rr!گ۽ΨPd2R a={6?^ӧ~;~;>z57x#W\qYYY_odԀA$kwqjiSZyF "ÛuK"StZN:kC>v&tcżjؑڷo_V^ /!m3p+])O=ǎkCPDP~"0v:IЭST9Nf_xY\V- UW@3զ] {oe]o^뮻֋/֭[ ;vp=Nu}YѐovR,7WUr;|*-MQ~`vU1 /4nޜx-[s%u~kc@?ME5aJ2:o*EDl؊rt4m+v^|5x3k֬8n^|zu3A7"4.ua$22 vRP yn˱ o~v إC,k|v䝰eWJt1Ԫnּ|kCmڹaC2wgऊ_~-m۷/I-vc3cEêgQZE"z!</w@8A.҆^)8eo?iӦaqqnpxA ֨B:sBdʫpBK7K~$>'Ek47'Go M |QGNO#d|/cgZ7͝BCl8z _ emcoӁ72zh =aӽQ>}Yfe(q}455qwѱ  qL9Y>mH Tgҭp˗kO555ׯC}lذ"#|6dĈL6|~żfEn]-4 ?.:?GOK5*λ y8 O駉xfΜ͛HغnuUd`0S8xK*ꩧJFt}kۮ:L8HR-ѣ9Su_G"ErL,lFN.WuUgwKk#gBu lGh"x饗8ppٱr,ؽ{L4WiIvtgz60 ʬom{SNx=ٸΓA lҦkXY]^q^կŋO[{#"KQ-!5@ߜA%n`l $5KuG+45;,1ׯo߾,Y fLM B'; TG&. !Nq<lx~%P|xi}~r]w=|^ll!/wy9Y= ]S"pv3,hm'M'[M7݄%‹C-1x0_^~U^~U=wǷABܡVRBFd9)e]1FͩӜ`3V`ǎIPXxcۼeB&[#>#B(p39읔@ 4iɥG_%IN=HPUUے: Xn`KښS}tfƊC3BIDATWˡ;zyf_;z4cVVfw0 ;!JǑ?b݄uuO^:PTT||y,# A[dzD8+tLFx;Hv}ǒO(H`8nK2z|CKH#Km[8z(~[hɿ5{l-yKU?9Shh:&PRIc(,zulFqfRꫣDII se֭|;~i݅ŧg J7T-!~&mỈz.DTFrmc%5H]Q5`D G@yy9&Mb֭|!~(..&T* WU#qӪ]اf_wֆp<1sIRQ +iy k1[L></^̏ ]̟?\䓎o/~s=?p Xr% 9 VޅތJ/3qyQ5rsQpu؇Ⱥfx Mƞ=FEp9x3a̙ܹp+˖-'d7^( aL`AkV3c3a a ۛgG!ӛcVÝ*p+W$;;u `2vx \z饼!=E(&|tLDix\3c3nE׀O@Dz WƖt 'Of8[,DߒŒ%K8~8-}ZL_\]`jw]BcwЀ!8P r4`$vI4Dui֭,]4oUW]Eee%_СSŊKn1Eq ;= };HX 2"A +D)&!9 7nGn`ʕlK_J~~MXqI h-WD/x=t@"q>pü-ѣ ߋ&.DJ۟lOhů,7nd,[|\.yWYf [lI/gn,Z} 8\^GxMW#Œfm_sK'YAZ(~ʾ<@rq/⦛njڛoɛo… Yt)ŀAeaÓ)@kϭ{X;9w%5Vk9P R!Ób:M9*Rjf@d]!i/] Ex뮻\{뭷#RX,ItG]2p9=^ 8>Nז fZ~> -#!|:^o~i}Y~8܃nflI 0w\ز~ fMBc!^jKt'i]ɪcI]/ט&)ȫ'OrСM3xʌ3ػwoBoo x!;e%o{ L 1hǝIcr9=DE혯MH$N`)8$8獚e QtKpB'F4`(..:6u,) 9Z#]%[ߩs`72qw@Ht[E7[C)%-5F̬i;l )^b+d.XQ$CBl@M AJ/~ӗWx9(.QC.@JDᘋ ] VܭVx DN]c4L$'i.Pg.adDBe\ciқF ] ] u'j*̈}øX][Ρv+N>a+3(8Uv4Fn4=DH vM pmC%Rˆ,X*x\V@MRx&Ùw+(?]eW=O.G$p^"LArHŎ4`('uryHiPKt.Mہ]5,ִg ,"4Mt$aEҥNH t/yg$E6+W܎ӋwhbC1 N7ZIcK57:B—)sh[z+Q `EC>TF@ ppc3Wv9yga OH ryCˣPXNcw"?v8 Aі3b 0OEi՗}⠱ IJ>H-[y㔶ME %j U yT5Hi"=N Х)<='9) Y>{6cܛP p Mk()R);lm3꓈ ;$Rѫ)+q9f 6 Be&ut]e';j(aoef8pI30j&W&..8H)LØ]mt!xo=1..5T5銶R7ԬG 1r$úMuaa^+5I`'{p]ti=tp8RΟh]HժtKSXAw1 E]ꠅp9i'M竩u!t$ BJ8yҳ8ٺ!VLeѥNYJN4]MنFR\ɐcر==3MW$Ɣː~Mq9kt;36(CFh9Sd=8GB NJD jʬ Ĭy!f21k(;upHښFDt5'1)ezkypnT'*ܢ[QqVٴrAz{ H=WN._3J,*9T+/zO[3O@jAt]h}r[ $x,cOooGX'mmxOe D1,͊dեV8}s!RCh86r;eH1}Z4vR19qz;qJ:q[GӖ.  wgb ULഇGe_{aե4# |qQz I髲Xu_U*8p&cNSfW7ueG >/B@%i:Flc| -S#ӛKVF2ї<2 ;TҤf2ĚI0nʼn2zNU?Ѻx 7;퍅.u.*b3H7Ⓗ̘瞉)8Uu'`!tz9f0uS ;ˢ}攥YIU1a_L1 M~y3]44 °tHAMP1hV'*3o*t,nkh$ͮܫKc!}&DIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ?9??b"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZTZQREORH֚KUQTQ֚#ZևZ֢Z_hJQRBI!$HI$$I $BI!$$HI$$IWWWf#?G?ꪪ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???k7/k$?? @ C??`"?`"?`"??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 149PNG  IHDR0 IDATxwT߷ KYX:$)_iK4_5[I4gF" .e) ,wefvwvgvg58>sysH yӯe`(0$nFhz!IMGQ<ȲBMa$YFd S# kABZ`O H ԄiM QdSLa LF@7z;^y()£qfK;= Y4m8L]QtC5@0ztTՋ[HM~bfCfz6H2Xw `3PPp3a-1 S !=@~N#;7!K2B@gzVv_dwHe"IGk*dŜƭxToDH0-(a=dQ a-Ѝ0OYR@r ]4BMB~Bf[ݹOq&9}G$u*j^O:^OumvK=sYã0L8# ˊI+ acDÑL=>O:i dEEddYFdt]C74 Cb羵L'?/y}()`dsH&|>57p ΂Yi7UQ?M-;9؀?Ѐ?H(wkVЁ:a@tMnV!y},|/x=r$?sЂ3k G֯l MkDdgG^V!i9(ʋo}G“c/eLJi,]jJ`Mde䓙s OX9}Ea k鋪yP/^O'#ߩ#\Is*z @U=*@^̘x!O|[B%mW|t@v|ЕF [AN?ʉ}kUHX ^cXU7sպ#T #-&!o`ؠɄ„A [ɿ,5SF4u4 j"ʌq 6$~?z*/eG}S90a[JNh?,"EUo-_Ea~1!-?XO0̮}m5TV&##\Ȧe&>ˍMhz}G6` ^,PUvs|2#Jv*>m8Lma rY2Gw&tSkDU< @5AnV!{mNj};Tf&tC)Q^j 'u7|K˄f!N#vDډ>F vbn{n!?SǟMUPP3F}`g4Έ04奦< C'?73Ɵ'Mꂳ&_F/@7tK`2b4ͨݛa1 %t^fzՋϛN 3׽<Ԥ†*}. < sƠ~AcX2$!u*PU|lihwyG&p7֟tƑh߮i(߿چ#p:# 0+6a@.8ct+82,Y' a 2ǓqOD&lAC`vBHڂ,]vڃۈ?@iI|GS2daκ̡'p7!&yBf;9S }'`kjWgwKr,(J^q&5/_mjTWeקڃϧ.UwaN4niLD˕?ؐkLpv[Ku!|f;<͢˴ .гp]vai'wQ8(߿϶Ϯٴ (KWQgˈGvڻ%ӯfE=rNIAn?Y@Vz.Z5i4PN{.lz;ES琞egY CD]r3 9Vw‚ 0AE_8Uh-OVFoO ?9#40L 1Lcuc6h9)?!`%;^:%I$]\J\8v 1 -Tr}G`FLJ',VTQ!ZRJHp9e!͗y{6aœlMl9[_RV ?cQX'y҉.hhOhd !S߇#ض{u"o}{ `b cNҔ&*qf͠9@PkF7tҼ:a!nỌ0HLaV`E6=iGnv!_G}SUc'S;-B:BQa1il>ݒXt%Nv:i9AlNXt87!$lh;czi~ Sǣx9$I3oK Hi}_$r2{yφOB3v.7?tʪmǭ\kvK2hh9(>DC75tS0~SWN-v[-qh-1LM;I5 p,!v1ke/Uϊt膖xT,ghעiA\d20B,Z8\v-æVY_ܾnVu!B%bfL0J~zlz+{YU^{b]j+DT䚂'qeР`Ƅ']]_03::#S/dI2ev{ټ9†զizAcs+=T'Hy\qv*cw8Rt] 8)-4cJ$fL9gqfΌ3}މbvǣtrVqM}e=yYBH١& nm#B`AI;*lmWk^USȲJ^v!lロiӦqE:?񏓞S*e{vVm692w ݛQ#!@^<;ݐd rn;ZXaX5kXf ӧO[n".X:aW:J'"Rg: +EBUQCrlz-r b ݂c0nMd>a~'|'L>m%%ܻbVܹd X1=u]XI(&8} Jm8X[ulrI։hMGk,zڿK$d;n|N p-@&MbL0ߟZSs3N.b5XK$AMas{tZ_@}1bhdgPpUҿpXLmT*a{*eSeKl߄HOOo? 3:wN7μfݐgVt,W6#5:TU M `cbl.[KIxs4innJz]\0#%K~$ɮX]Y鸭-jkho,b Nw?4 oH:*C%$=6iـcB7;*6=Hq"ο&@lfii=%![,BtҰ\6i`9ι4J'ɻ+C_d/y_g/ed^ss9x>{nT4Uѿ0$5 G.{lm`Z_RKhGrӼn!^222ѭ//x9xB] x7>.7r{nv_g+S %sN:am iA3|Vή{rsy\vkWj@gQq0B)Sn:q#vc{>A7#.D${W)Sqxj. K$ [vC]UܷZēasiiY9*o`S2Ymb_v ym]F sq_Sۮ g֭7?g羵1S .O,;3[5`Th>`)+`Ǿv,ᄶ93WXJ~vLdP{98w2ҲR ۯ@ +Syn馄3f [ӽꪫtW ˖F(H̬ɗ I؟Kw_Pr3{#`ǾOlj&tn)ݗe[*9x"OC.?k2]EζV]cA LHX+d &4V~}n@enr2{a aœn>  H7st]uKJ6-kWЫw;QeS~`4vy/8i,e@ 5:|A?`bYM $3f +Vp_hIWٞ.;c5sC7w1iQ![[q/چJnT<߶0qO~k뵏z_ٱ66-;(Tjvu⚉4䈿e5zaƟe@BuV{L LVVV;X/zOC tayXd /"_í'8pX09\7c-42 =(HRP?mq`Uxue !lȻaI2u9FN4vB4_ GhWAkFBGxqKxߚ!vGSVVƨQq:ͥir) GNRo\3&\/b椋<GvZ]Ǐ GB!Mtow|]l%ڦ*k ٓ14RfS}M!X{5a*FT4zDpw*DU<9Zx10n8N /ys뭷uoRKuՖzΚ~5RTdI]|zU~^ km> "R*8Z [2u٨_K.aÆ!I_Wx'ǎ˖-5a D-3iy\~yk0E46׺=1j7Hki<ןEh^FGR8ڃ4v Vމ^z)RUa&=EQ8ywضgeF {hg2aWprIDATNp! $IF#e M~7nx#L_>s+,́ըnt3x)^n./'-Jm͛YnSLG{;+`Jk90a .Ş]6m.m8J0LX r?_ Uh~cD7׉zv+<g3=~޼y,YG8tPvHV( T/rkMnKnSbK-׶Az7s7o>,q饗r=pEHL}7Cqۺ8o2H˶GR'8U6yK@B}掮OhֳP28y}DT8+ZsNg=[Xb7 *wȲBmaKӸgۭء3(DzډF͵kCd\[oXS/&$4`|>ey߱J|4MD[83")T@$cr6c)>yi9`S mҨv%([H$0%HyIJFquu Pe ,ء3=ǓG*>TUEB0ttSv*JL=Y+hzM;8mߛN {:e c)b&{D7bDlvj;+,9Vb*Õd*)^4t4у,n">:CfF@OcS= z-hWTXڨu1K$zrPȉܷ>{g%=!8mE׌:ꥪv'd$I Iah*/FQTjHA/"Z֔560a=dQof 8xUzZꫯunܵqgٟFu5k:qILadZ90ĮBUc^d׋˲")n.Ug %5_*c ~|ZJdIAw /bUePV3g:@FZ.;NO`fz.,TnOA ^}He**Qi6{"@G%Nx!pfv`Չ݉4t| {map6 VM]UvS\ɋ!Fj9GaÎU۷[o`?Z{n0!-@IѶH|vos `e|)`Hfop2G#Zw@r iBBHJ*J@RKu[#*7n٠PNϾ{3Ȳs cfOSD<&_d ;"9=7.qVzQ}hZ!UBVF>&_ʻ+#°n_ȒE7O1tE8j|VuKXx]+(y0ٹo]yP8 LV?glh6qn[M{(uG0Qt"x"3'YDYv.{,鱓!QYRm_ċt>zW[/ᚗmfUvTHd)koh145E[ )8,1nKp. ƘFP+nKP{J'4o2X{\ MB4UZl[@)b&ꆥy3;5[E9\GGľn/?FwFӂmfLjZ0DL$!Ko&>l)_&A|DQu_8Bat=nh,/z*游SH.|ښ3^&q:~Ey!z9eΰWt 6uox͏ǼS5ZhŔWpZ[/!k.Ds! >/,Fx]źmu!(;%xT//Gω%.&kA6uϚg?tm>,q0xws|kο ѝl߳#5h YrDZ[{9Fm_p.,1ܥ0uwwVwWbLӤUߤxbv ,s.N78e %8s0ACӱ/*t.Bu4ZnթuUҮ8m2r;%NO!YxFu]%*R B !Atv=Bp&9g~4yǐ,Qf 9ZCUelbQsw u`4Ժƣn"KX[Ja뺎,8f 08SwiփTWRUO6}fZ2Y1 p8@YEj3XSM}evMABKA5\X ϸ~hzcu<7%>O: !pd7d9͍>i,J/ gNfz.2.9K)Fxlj9Phw\Bri sit CHMvje@7ɀmItUO ȸ᳸~:%4.+4BJۀ9WU<濟ܦ,|l߿'Oģ$)5]w@[Pr)O:5{[fY-FZW;ymEw1zw_HAN$QUw_᪫'ᦛ3~<|Qà" 7a$| ,^ۺo |H$!1IENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ?9?sb"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZOTQ/HZ5֗j""?֨?"R??C*"*TR*RIj֭jGI$$I $BI!$HI$$II $BI!$WmWpW#?<@ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???WxpW$??ff @?????@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15*&PNG  IHDR0 IDATxy|Tޙ ¦V ↈhj]Z֖iO>՟v՟jmU\ADdW ef.3I&Ly&3ss=E=|$ L7]ЅQ5M+-z38|BYa{N_"kLJr*ؑS@meB 7OF ,$Iql\Kނdm&E=4-kBh3=nSD%]x3BҒQu?yI"cc!.AGmaK#$(R",m0!"N]đ%YQd%]sȃ`֔#]Any#4C㘪W]\y]_#q8:F7=k?GuIe N()/5M"ђ\s{JcX8l+@#m4gz5Nh>8 ָ9SXÔC8?/ZO>~Sg؟0;3'-h=jɗ1bHcr,)Z+0&⒌$I3H<ҽ8IS@R/D8u͠$!$0W# 8]qNt֗6ےG |>BFr, ѝ$IssAZkh~ " l~n_qTqЉHDz[iw6yƍ-Dl3u|4_ua~N W=C0W$i|ԅ0͉:I3s{_tViY8ھ5$4"ęy1w5]E*;Nyu-2  da< d$YfߑC.*m!Ҍ9tMeTuG|iI '>c)]Zk IDsss>v歧$yx=Lɜף[y+υWuzOؖ㑦USeɅ,IHb{. /oU|Ny|4>~c%B$Eb|*O~cFBe^9$ L iOC7a̝ cwTt=y< x<(K=T՞ ~(˷ɲX88kZ1L acC\xy̕LZNGCCA0{?jzs,/@%ymX), ǜBj~76CI5'HLHiW#BPTKCCD[rU쉗{BD&L&ɱTp'sdv'N7LTV,߾ΑM1m6yGp棩Zbj.}X14]e԰Ij"8]QĿ>|ھ10}c wqnc˞B8b%lsOg8uMB$ъ4CyqΜ-6iQU{ o#>-˾ @mC)e{#3Glpe:3NokFsA#::M9dB9oDM^SV6GcF1>_RĹVZBT#36># 4&Ⱥ!f2by?BؾP vHѾ[b8`p)nO7. T9Y^}I% DdqXFD$5$ul&F kII74,_Ӛ0>[´ J蔘$NM}ymy4ezdl J+ /UI2[e?#d 9A # t]!tmkRڥ1A5y$Ȳ: ]_V!D_a~9Ǝ@PR^lYvke_r6bG dƣ+GC3Iٶu{݊d$ [[8+>ԙ~ `X[>Bԟ#MQ*.=,+(Je5?7$KO1Vf:߶q[it]S^>|x\xw"nW\hƑ#G \X)KIN0C~y`DH"Bl  5 }$ Ѧ启s%,o$I1j4Μ9sѣ^c~fOX4,iOP$dY6*Zt~ I'hGqFSK}_QĹs'.w&/MB['%3\_uS\/َ} iS (>T=wPj !D'c> VڂOxk5 &^_o]IS[݁ā@*j+iSEEu g4p^|?@!VU1Efvz/?HS3hh<+Ǐ7 oWmXxwnWǶ:3T|)B$Dm[Ҁm-}|.$1D<@]&Ksc2]䁮/#dJ tJ Uڵk9x 555 {.2in{ Uۻo5ҒmČC7ReO>Ĺߍi;Fk.n]=IJHku.l# U_4q(,,d&goQg*8md;%9֮զJb!STTĉ=)ˀ%t΍vJ^+j, ᳪBT͇idff:6Lm<//APUU#7r2!!7g8#1e'kLgW2tS,7UT(y>wŻDBr3b8nWZ'8y>ZXDhSڿ>Yp!999\{m'I{ ֭6i'5[,^U3(er/磃v[[,ZիWGee%L>o{gN^$$ŧ*B<^ǓĬYx~qݺ0fB$}#%8w.%eKH#I^wcʕ\lذ2ٳg֭cРA|{`,_7meOX$)$ŧ1b>9nX2dL8,n7/{Ֆ]ի6F ߂Fݜ8=L=޶F H}-۽g֬Ydffk2W^իYbE&a a۵5-kqɀI{ 6Z`|{g?YcՏGIBAF0i9VԜ$ޝHbB]TTq̲0yE7F:M-x}M5PZUd4O5[3Le̽Hskt{-[pW& u-wFHI2ht37ȇpcે}z! y7:A4bg}N01æ ɆZOR_v(babь-FZ|MXhT՜b`0m"M(ל?hصz5G3AX73M*Ag{8,^;3T \0|!z>u73l0zNFbFS]vk*jw0hZu8x6i q EK3w~ӹN hcV,d#iP6CEYx1\s V%4'p<#wמ"} !{ζJbiz55'phd fq ;IX1 a>ϵTt#>3'7on:F`bkEO(i}顪ZbB^m3'^"W~ɬ+9w 4j+$99W_jJWYd {/O>$dd'֬iE֬{![o!MMA|2Ԏػi(42‰oi^y}Y~P]]m4Ib?Aqp/u撘x- wRCWHfʕ466;8={xihhhO5kZ~Q'N~~~ ?3OOH%Iޛwk>ʻ֊ȑ%x ֮]˳>5UUUݲXNV>i`#y>ԙ2V̚G K[dt) 宰e,++^`kǭACQidYA]x~G@DS |ȇ\Nio5BV_c{:orv"Ǘe;Ɔ Yg2ePT8'unoi1|ѓYƅ^أO~ 7Q)2xY\<{Vv7@d6q׊4i. &Vy(d۾Vƪ\W9rY8Żv%ՙ1OIӤ8y$oi+(* ICU}(J7D5Θ3kSlcUs0t;7x˗AOc⯡>AUW}̝ <&G6{xG{_o7cj¦OؾH""-HQI.E%HH& bʸ{/"e{NOW-U_Dma><͵TוiE|ܰ3S_dQYY{ c3ͪ,c } OSEM]9~Kƀ}mH 2$j}[ͺ j 5賁oSI,ڐe,YQ_H`O,uKEuv$SψSTKcKuJF$cժU׿rq-ձox{V=&4m'G}d9oĭ)K:ʕ+x\I/.SVYntmQsKRcK:IIV# `OH%nH果 0ҮEy%$VhUd&sdN732~G}b(+P .DPJ5#1 }I>@TlמZpǹIKJ7C҈ȵ& Cf,d<[G%UIQ"N~vF]_3QqF"# X~MBv5~  m#M ;{;@6<rx[+5z/mEQ8d©C [| H`Wx)DS.Xi:ǎېfќps'b$ȷrs}dBK/PXtW5ș+:4]FLCKSXβE7s#k~spEc;͹yWWBi'{`ק[V&K0xz}]:D8wӳg2={Njcf>;rL|Pv.d}W4|HJKt|^U,ιɓGK ;-C>R$$Z,sK<~3dp wNlmeUm*FIDAT+5,pp˕%-e $SPEm}gW}iN@d| t}S?Bs2`LsK#U+L p$]S#S>pdryC$kڒkp(Lͺ LT؎h8\k(OS- M5,4vHOFt!'"8.ˍLcs='?u]w&#Sc'a`ےMX"+Ȳ !砶03CuZ*O2pN`˖ JK}@^ {,Ϟs,HL۵DcuTRd)uْ,+WMma'-%Ev7S"&rrFjk[d,٥ =D&}o 00Be~R3$ Mݦ-z5q)Ȳ9[[ ] >n:KȦwqո\qduyĹt$%>Z+`gu]˭(4;?ϑ2B:^"z`nōx1i8 g@|\"Br|Qҁ'i Jk]^4eso%)! ]hر? ="N;hl,gf>쭩AwP@r+]:{ ϋ)v0Nę;u)`&mqb'=4Mgܸə~-#GGG*v|' =9NKN'!> hc6i hL3τȡdYRhhfWIOoHwQ{E,){RVEs.{+ɉiH@SKcZv@©SeT..ѣalj [IJL%Ν_Q9 1_@иvw1,$6 ,o_k[2h;Fj*ؙ$%'9q$~Tnϫd=|!$UQ[tXG:U5ugBQI]>$IB$jϰq H)q.CZrظ+Lʁ{qo-/I֭󜥴(<t8fSƯ?7 S1,c,P社2@9 Jn栫Xٹင$yK)&!qe- 9q Bש.aN >)ӆ"IMu2y!s{>[U[x_\1# EVhjPѶh3h79"veE[O F9v@ʼn).v%1 uDL=W}YMo@:bIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX 9UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUb"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZOj#ZR5UDTDGGT"*?C*#ZiUZխH $BI!$HI$$I $BI I!$HI$$WfWpW#$ꪪ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???g g$??! @@@$4?` DZ?` DZ?` DZ??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 165PNG  IHDR0 IDATxw|\>gHj5K.-w[Sll18KfB..Ivd7% KKY:j+nظWHNy~23#Hƞ9s<3=ynn!.0h]v.0E 0 OB)Wiq:ík9AC~yx=~ 0 @0se)JIh܊[La0gH@uTtC㏛@q1NW=럳h @ |vx3Ic".wBWpMsԇ#6lb޴Uxs4&>:^Z M!B0}RƖO0XF^n1Г-9SDB|2'1,S,'_Hq~ 4gU3܂nh9kD;P]p5Uƣ<̝̽r##y؂0r:{gCjkጵ(.7Ol>OKp$0t CZSkS_I/9MP(>zZ ζ? `9+g$HY(86&VAv)Vaf^$hZz=qx9ȒbpL/ Ǜ笕^O͙C膎@⻿Ba3ײO2.P],}A>]{9_M׈a;rq:GPS5 '_H~n K(0#( SS5ze غլHL`3gUx=>T5N$MG2G\f:)S_I^n ! gGa UaJ X=d~opdA(K8|tO[RQ:9p| Y\;膖S#]n *銴#Y9:95Y2N*K'"I2$!ɒЯ5330I 41s(>î~4άu\Sp z&(ʯd&qCn>Ϋ=Q gVXZ|lۗ5y8p.݇S!Etv,Eن}3D!tC񓓓KKaYwS8rPW+Ai$sr-SaD@+2jy uH9]S{?g,CDb4V|#a>?pDb̙|%ے vBvp3j.gR-@N>q5JWcn8xF84B6;zzF"N97b7V8Yg{^GbwmAXxΛL3$9Qϼ7@\GG7z| 3#8HZPqVt=ZjaW,WRo۩2kҊ!{G_D{`zhZ3<<03Qmȩ]t[1.MG{=SCGqd'!B?36ϋLy.snģt8t 4eFQ1W#I;/8p|Kʂzԫ3Ok9vܴϘ|퍸̘ H,܈@m:іB)0TO͡xW\1za``tt[ 8^glOX6YEjQ?VĪ%r";l ͲQ6Ei 1M,-'H9n `LTkenwx#㱵vCc˧"qb%y7 u UfZ8xHi-&zOl.8[\R76$k[؆ ϮqS>$:{oL>FL&1 ZMm w OBh0XJ,,{!R}L5BQ{qڡUems| f䣩ڦ,eߑM^ W$#24ԥηlLgq&+/j֎zv@HA A&+NEl\-ِ$2!'lr' ,a!.fdpHrc  gu96V./HLqnX CG]waCR{$[dwJ-@Aިczgjb>:~צLUR{Moy+W"zjP[ C%+-G5c+LrTNF$0㋳SjDeJHB0u">:\^&MfżP\\LԲ]T;tC%+Ų]%9ӕoD8!?ľjZڦ)p#8戺ϟC͡Z:s%.4-N,F7tB]ʹu6r6K B8qdIF * d\[-W˘)'1crnHh{DŸ)-%<P6TAU{iFnHc3 UW#Z>'w2qL23Ufӎ#tG`L^ٳ2a}z&˸eoˈL` O I #f4tPV<.rvM;˧)8V3Gѳ`뾏,CMahn;3tèjˬGMdG g}ǝ8rzF϶};t?y}x^^/ǃtH$L4+DPXxhP#4Ψ* F?q(k j+I$&n>_nNj*x MSMi*xL[Tb(XhHpJ F#.r|yE<{y ?0f}'4%VŊJJFQR?o894D!dH,{^LKvZNnƬvy>тo璗D"tvs lj.j!xƴ4M*+.ю!8- vQ5tCeU'bzY>qA'=s\Q<\ X'ͭ8sp;fQNp|OjV"~^cR/ic)+M5hh<L_3,[U<eEc c޴Uv^v]7;'cC@tpTV뤜5 .5mUhi+N[Gp+15i3}uwqv&Ul B8BU)o>ww<':kW}oY3u쌹G0v|LhnR+_~g!E yZ=21mHL$->}u/9"1_'?DK rOD_ZZ( Ll_ڟ0 g@~~杵!J{W]dIepnZu_Y#$I"ne;C7pC/[@dϖjuo$>c@VK{='Ha P  Yr~ IJ:V_gM& ] a0g@*.dE8/q33 }ZHh,B8IWp7_CU^0tF]v  cs8q\dY%+dEȣ$BdǏj#J<!aOJt_>OOp]o4:}Bu%"pA4\&9à#Yd(>|W'|M)/HY%g$Zvt]t עeK\,'D5'8f.*q5J$bnY5Cuʌ;J$z~zi'_DAW4zg pUUSZӁƆa ;T$ +8= j8K0l7M I2nk`nK0rm>JIh:$Iٷ~YS:j*i^5x9rj}LC -X'rv$Q^2%!uII<ց"_a8̝G8AEI Qtt60ydM;l~ԑ(;VT=N~n5&Ң1k>I I2a$H X(kZ'PЍnhIi/mBj ?we=".܊ )/I"Bh Dmj7$(+6)6ӔfLTN~+ ֺ~D;ȲlMe8r_ɶywL!nYf^-f>?unE}yv"!mxӠۊXH4a-)JIMmn?CqA%wp(/oiT S @]u dW򃡠x[p*Jjd|4d 4 oT*;GCgI ՌϛK4=d@p$\, M1).YtO?4O+o/ S皏QVF(_Kv(`n%Uᓄ=$x$l,-CcIZ;,g#swldc i?+SV</߮qs_qG8#yi ū=HMtt$IT^2~HM3c; y=Ec{0;f%MRwڷ# pt-8V@yg@Phby9% ǔO5M v~Q&\w;NHL]]?Z͔G#;x=MnMD ! ͔ү>0t>w7?>(7=j"0/3?e֭/1%#&+W*E' egbG]n#dJ$W# 6ppIfͫ%O:7ncgL'OR]=@߼`:֓v23AX5;wu[b傰$ܪM8KC6Tvf%~|F3?]̓>-oŰLbldFǜcPpp4F/mkksL sA>r W;O=mmm5ڼvawc۩`{a0r £=:ϵDJ`1TuNf:oNp/ 0m Àh6lRӑ?0GlْYZqhi(X)3EI _=-xs.2i;#DbkA-ۉ5A 7̭ޚV+WVq6G٢p0/P i ]6".nA6p7[OdD]s1Aa0շjٳg_r6j|Mn+) Y*?Z:nR'wZ'ȉ0~u3O³f*YfΪUMPq*dkKsZ!/^ NprNhh;У27]̘5s}uɚjR~n㮻x}A!0^}}^'1?&( $tsmfծ0XFa^ϼo(z/_N,cǎqAB/k9RoQ[z_&H{bݵrh}Y/} ϶0X[fDdɅ1P­xijK?PrɊ@-ccҘUXEeI NOH O0Pm+Eg%w]{J-,˗/g <臰aA^Sc0p:JjsKP\{O ݠۉa;hl=t)+m+N{gY'%ɶ&7Xe, BVX ŀe?V_]@rkBc$ւ,'w{GLi;5-HbF807_SSN,MB7!'6š5Ư؋ F#aVINV!Ã3Rrboz&(/g,kq+POy8o~O9v;Rd4БT3|d)3{l***|[EL;|8,1TrqLBйS S!H'wR_uy6^.2F׋a輱>(.HJ}}}P=`Q@M&k޽~K`Ϟ;eSh~tG_?,0Й)N]NC[~BuK8sJ&v`ZRtCOf#Q,Gd>>ynltML4R \5n;ׯ`_*߿^ |,`ؚ}Z%+H4<^smB٪^kraԎOL{DKY' S-D746|fp( Zxi#+Ӳ=|nͬ xm8jkkyuh^?aڵ,pIDAT:AA4է;9MIERX1YMe#ӻ銴[Zhj;Mq~%Ue8u~6V/>oI7߸EQTTDNN۷gt~QYYɉgкr ȤzEibjxĄ&_zJm"6D9$GI'il=B)m!X8}M[2zYXCW^s19Ž= /nL0>idVElΰɷfbH; OQ|g=>IJmj;ES)Gڙ`ьf[ƷW6W6 ,4=gn3al..0Ġ*d b]`/7'wHo-t[+K 8 ׼=fq(-ÅpoSp̩IGd>­ZL0L2nQ?p(?J :phSqQsIMh;gl,閹®m c=+ԴA7nn%?i1%I8p0NU 2^Mwwdm aӣ)rND"4o!7o7@M Jx%nJIZɐ2B%Qx>g|ht3=,V ]-,m : kbA}! gt"/nfZrǚg޴BsߥTV4!1O%g׭HY;?]x$NW@N5B -}H$~%B|fӒ.I,/@B0}i^^ 7Iϐµ/W ;N|ID(NMaM=B{+/Q '-""E445`۾WD{nyD8(!t4- X;L &FDhD=$IOUPQRw>cmRg50>+YpacEyg7t% 1@a3$$_5SۇybvO}Ay9/O[qRZ& YVbJkS"م0^t0U߲^x1cæW(MeS2 ҝ;>VkRtnj3ؿ?}dN@7}:gծH;x^8I&zԙ> \BfG_W{5aDb]~z!6DI{ o8L*Q2z!Ea˖-,X04fQe =ƽt;^)ME{puױxb͛7:y$51-(NlB}w999Ν;yԐ{ ]/3ɷl5z|OCQ_)JkEUimFccwuװw} xΣ>*j /(|ހp+=fL` ĵg94\ylڴ)@'lsnvD8L =9\0ºƩВ Yo6yҥ)ZYFIIIZ |9>э+4b(@Ud$"2V,X~ٳٵk nwu0~O(ڥ~A=t2(Q' B߳a/_>l}Ûo&\:8&+A`;+m !(# =|`ͱq-F$\SO=E~_\~력KS_',^39s LاxV!Kx97B&@ C`l% ;Iu(@DsMj1Z UE%.r޽ d̙VܾexUnqf&n&&UA`Gḯk&:R-}#4ɘ8}ah+9 ,ϴbѧ(ȒO;+l޼Ǐ㏳b ۶Ì3 ?'0O~ DCgFUc^w5)WтH^@͛{7es}R1B ̉j1$;7m+ߜ)I?q\~I UOi> sr?:~1:)N sfLXn\6 ?mϠdٚ/ 4rOKQS 1+4fSc71e" afn O3/.ByW7ye =]r,FvdS/ ޮzo"8c;Q M2&õ˿pX;]bk,s[(.Ŷ} ϬIq(iH0K$W %ddZqbz/bd ЉwvSGAK[=KmhjCvɸ$W{5yBgѭC몓dgItX~Zw9vTfKmLHʖ &Tױvٝ$eQ8q-9;9&_:bhn;Mgx5 ,s<|(A0v , 3ˠ(Xnֱ4Ůo9הTS@@'Wĵ'銴[11S(-&63 OX{?MQച%x3̸l6 S˃&qyfFF❴vNxV_d@_IĈ [(Z~M*/<DW͵yE3DUrq+ެ@VƖ%O44׫IAlyͻ#̙r%^w.YT԰KX_7*$ƩMѧ)υ )]^1bߊߗѴ!5]EeV->hM&YkT-N[DN, O`1"3seQdMfn թZXGET4]&U=N[O8zzw/wg1~LT Jqnt#;MBIbͲ;پuT=f=fN HWZ㾄 &Ēn兒­tEG;X]HHSَ>z;ç>t/|:!Y&'Щ,y]Zn8ȴVK!'^`nk|J4ʎ`5lRʉ^w1 9$^1O֭C:$lޠ/ΌDuw?y~ǎSRXe3rFR hB34E8kq+^;QiǶCO$I%+\ .ٍ,ĵȐ(قr5oZt% 75uB5$NRbh,l+x @`X_ I>܊c}*>^|Bywʆ[SO<Yr.d]CqlˆBy7 _xo\TjQ ;oh9Vߥc0}A9rY^l|!U {| @R­NfƵ'[u;w"i؟O,/ s~lmt"8g݀MGq5BLfEUY-ye{f|Ac%?"IENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ?9gUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@b"eeQ?(/jO#ԍiQD֨5Z֨?jhhT֩Z֤j֭jG?(j֤H֚KUQTQ֚#ZևZ֢Z_h*RE*$TGRZ$HI$$I $BI!$HI$I$$I $WWfW#DsUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???n~vn$?? @N @@@?Q?Q?Q??@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17'=PNG  IHDR0 IDATxw|m͖"q7c1jZ !M/@nHTRbj TneKU.jcFG 8V_ش^5dXdYFd$I6_D+.KH AYHx#-Q($4].YWQNPF zQ( _ȜS/48 Il)?[1lWEye甐Uˑ.4:)/'˙S/}:cSl8.:-u6rv;~Ե'7ٮ|aDhkGd8r6{7`+YV;1t1H ̟:Y9^UT5h}8D],~1v!Nijx\t:~vw# P;ٮ| N;sx}{x: .@GkGuM#l!7ŜjC)!1U{g#]x}nL(.K)vjb>Qy(4]3#hjTr$>2șq .IliZF ŏ&T-`:: 5'tlwwVg=ofܞ|a$ H'G9K02^/-5 _|&.FU@DYI%$!Wq'tL`O8j6p3vw3BrЅΩΘt>[Gsg_ F[j$a4!_,w6^sN|nO _5M6x@RB#ߍy(l>(t9^Ӎ7 Ye))ӂ0:}Iw:_;u;ٴml 2a@-cHĨ[&EJ2p6zT柶_"FcAޮn(Lp !I21dsKu&|0#XmuvC`s87u9붟Q o~^! $c5i\Zбh)$辦MmܔDU4z$O/]H͖9?/D ZGF_^t]#eN?!\U^'Y'/Uqk.)/EsG-vOeiJXO^wu-A8\M6%0rf]%._E2X\0,g^vw#G/?蝰ibKT藳 BFDtL=1Ruz' 6Ŏ梢|kw7J 3}?/MLașBC$7 i ͇9tldd$>~_7QoxqJlu@{o#[.mcq#fDFs: ]u 5V!IUѠ_aU΁2!V+! 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"7,!iA+e/ ށk:gy+ś&sY4zNO>Sm=iڥXY6(+Em]82p@0o0AʬH`Wc4"rXƒ}Mj[}J^|^eccٸYhJs{-ua\x8sC02BR#o&_%@{͚#U !& Ew~m|DwO\8oM II ecVyo0{9l۟lS\PMz,95thE# 0G2*9hJkG=끇9-97=tvݒκzMTI*BB=M M E䆶g.g9Y1"q֌+]:]a2usˑ/M,9toUL&qڳN~v1$jz>Z>1R*Z{2zf柶24]ӒP%Sv ]câi$Y6sL #/nufݙbk5&i,T?΃rڄs~t c^fWS@P gO^8wW`dxa| vlX Y]rɷʣӂƝWYQd槽8^ͮyJKP>x8|Z;_ln(-,+d9r{g٫xt#$$I5]FBAn1u}7ۜl$DW3Gv)b tZhl}93~L[jZ:a<|xQ1WUv2tUJo_( T]rkCG_M~6WmFL`P;2WjwPQ>E6\u\tؐ?fFW'{QQM.ǏǐAcA2岌hjF0aD+:wM rF]fxUמ5y l#غôx4z.%;M✯0dE!8RGs[-uMU=Rl 1a,T5arU/6ǩk:UIz @2nyݲ\lYr $k?EDN]ᨪJ}>/(6t]J0 lamoSR0TtZCS[-MUDb_&ƍ,+eqlD}Ջ d.gNwEmB C𘷯pܬB|qg፸:vv-510Fv5uG*8jk~#,WUihCLpͱj 1çW9z5h$v=ih=Z0lW0sfTxm,wƁ$vDɲkxU i騣do;NO f3lO:ϝBV{x#6NiKsy_C=םYHuYoR,ۨ' }xK ]T-@ֽX'$'g<C w_$|e8s7$S]PUhN- ەgv5ǗDn}BOpٟnc,2f>6Ł x]zlκz:*F(T $ەg<D FϵmT2.nszFI=d[kG%%,TUN>`E! B?y_Y~N16g*8ˑ$!:ٳHl F2:YhlW]qy6Ŏ$d1@fs"I2өk2 eP0$+)i@,RAhe |#gFϊ6F KB(I'"cY>Kl%yrBb] I2J/0ٮ|C!_~4zvEeܸ[/fL@Ղn!I# Y ?cV)˙ +>onV!Y15N6\b5) ṫmr?3g6K{ocۨES[-6[/O]anvYBɌhQ תRB`FxA6G)CꪍG8pd [j>ѤΝSIk"6Bm=(J>θERLJ59v&rm. J(/+w5cɯ{MY59i$ĺ37Rul5uineս;"1n,1N0Z=b8 K఻۝ EuC3R@1|2^S^WEk[7鄼hl|h#RpUo"ӱ]89}R6#qH%[jd3-G@2tcaxD]~%++iΡض{CX~> %ەɋ_=Q_Fup݅3Xcs$)p$@USQ .gŇOŞCih(6|}',)'F6de8G ]9\]є^t $|cw:5(NG6_9.A-dvIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ???93?b"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZJJ֡jGԍiTUTEDDQDZEJ*U#*S?R?֗ZUZԏHI$$I $BI!$HI$$$I $BI?WBWpWW#'?ꪪ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???NN$??h#U*zt!@?????@@@P@P@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 18PNG  IHDR0PIDATxyt\՝?oEdyox/6`1`ڀ'@:9Ih0I„&t;x cl`K$kTU;WJeIˮNUzJ%r+PblRN( DZS"-J)%HpJEI8%Ң$iQN( DZS"-J)%HpJEI8%Ң$iQN( DZS"-J)%HpJEI8%Ң$iQN( DZS"-J)%HpJEI8%Ң$1Rx(t]pNZF'p41bVUŻenEZ %e uB@p.f7h\>9h8-,<0򝧮xb׀gd`TCO9|:Z[[yŠkka"*`σm K)*Nvٺu++WdƌhоV"[Ìc]%p{v5y~oۜ9s$I<9?İ㳦rw5e8rdEEQTY!D1ER@dʕH7Mn1àGf}ٜtcn3,,:NYEE_N0BhcÆ ر 60sLbYIyOgFs֙ 8pjn4ͅjh-;_iF[og}޽{CY?o4g\ H2. MurV`1>T5f`u⋃_r% /ze! &DcmV'>ul@ Pɨ <~$Hѩ>]{dpxzoDZ > $#歸5zC8uՓ@Xrji.t=Ƅ Kb* 0 $ dˀIYvj9^k:#  YHF^H=G1 EG٭w+k$8>&:zԁkD̽f+lrLk&s5R3d˷s5GEY-q#NLkLGQv܄yGLL\ApuY{4[ 63ΘSpͲ6Kh G4ifr9sV)!yd9Țlwo ]^S@<Mq7,K&Mut]'=Nw?NuuuL v|uOa=̹S'vkuUMD{#|şi&h& ̜9`9qۉ1z0ayS&uY]]*A,{.q>.2صkx`u59 MEY-g9|K s%!t‘;hD?_C& Z\@lu]:1.Y1 B{/?yOGr`Th w9c{F[QM_ tO^dm>﫯ʤIZݧV$wtZS4$Kx}x[G$HF@p߅sis ]w\6KH$xtqG\FgOS?XXwExe&/$^,h:TA(FVɛpXr'g9y-ԲCcId`z&:jllě D^s_c (-' >+ ' ?#!IlD]o _]dE0t~fnW(,^p;+p9p:ʬs8Љ14ECo'b_#!QDUɤA4׃/؍C""IW5 C#&QU'j.Xye hѢiYPďCsvrtTⰲnid6ѻ¾ X$`+!  ty3ӗLu%\@U4& !Xuݼ5/pX 6 fO["UbUuȊ9dX" Q1 cZS9La%f齶(?ILJkeE 38Gz Qjldp>Ѱ~zyr݅* ݖ:Q5Gc(IXH4HL"p5X8.;3!*a 0)`O0#ش@B84'TQ̫#oy_zBHqBܫ%{5K ]aͤކn%6|Qb(x%j5K{X,I[Y)ۄ(*PC0T=hlށFoƦGJs{͊PO(E#KtxN)@э87ɵ1d.Ca~;BzA&vىQk]}aYtq憧N>&(ͦIYD`iTm䋡T+d{ҥh $6\+^GǴXRI:pd/Cáv3u8Ia?'  ´hIbSN}OFIۭ3;eEPYT/kX$- 2BXc?:hsWpھ}'G(㈔,(ŵipo\hi:aFh,C޽VrMF],=Ƒ+A 6j&eTn{ #NSߞѹDncEnPğ"r}t}N9' X^~(6ᘈܔLV )`޽= -H,q?g4477s=|"+¹oy|Dَ]w]9 +ϑHIW,\KIES1umV,N813$ 4v8!4u]y;_>X8w_8z<΁۳Q 5S)DCCmmm۹sEFM]>fޱH|UbF2#!ywyYft:[6ٲCHBmc#%ՠ׮sV!8ܶ \!)x<:@$I3g9Ҳ;㲋Iw`팾-$93SȀ)R@u$3gDŽ%Niz\Y`% IȲLCVFtYrl }BU$YFS֤0sdHeymm$8/X뾌.6䬱i[ nGl$@BF0FHy0jt#BLD*[VǺu&>H^$$}"Iiax$פYKɌX'ct  :%w(J 7Ѝ7hjI6q7*3H\f좎dpj0&NAlx,ff CVMDQTdY%Ljҟ`qR.=-s]ȳ/}.7vU_e5c{&L`{KXm4#q߭ccI@UE= E9E?g[a9pcTzmKU_sf.2ˌʭp ̾] ho\|b$I,sU9#/ %w%l-"jn? a8҇ˑr dbD'5}@XvM4d4ZqV'¡q*$b'ȱ ^ݏ~VĤ@р)_

! ?NuAy-NPU>. U=uжކ0ݽ͙sԔPq=6?GN"u\Uhubp?q a컵qcNkhuB\+ڝE7siF5p|y`)@b?o>FbA^I+\;*y+9~$,D\ǠGl!~sԼQ2CHj8N~ n׆;?x^HnJ7OtSX!>N\2њsu\K {sPH暴"<"O!cΌΟOG?! 1kyJ ѧˏ_PCgl.6>ٻ` C_=1.g9BQVt9OFq$[s9:.^ ߞtCd*Z"{/H"ѱѿ #Y3`.xp0/^3a=%X!Z! fg0BXDSʇYF?C訪z>N1qedqdYY8W[~'͇ac !EM! b=m"asac3;pϾ~#.@5M')낟?|(MέfM92W@BWQ8q" Fld: ڜC ajNyH-m%IIENDB`move=1000;blend=1000;3ROIB1; 5; 5eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZI$$I $BI!$HI$$I!,p fRIURIUI$ԒHBJJ$B/IUTUUI""?$?JJI$I$I%URBU_TTJJI/ $Q}binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}13RMTt2:2:/_Z֟G֤uE&I(jZj#FiQDTQ'#uE&I(TQDZj#[TkWGF֨?Z_']iQDFR?EQQ֨?QQQDjjZTQRH֚Kj#jMjTQ#TQLB7\],m%f! p!33mkmm6fmۀ@ ͳ3mffl 0:119 lB"KmmHDLGG$")!I$m3mim33;mim#m3330 0ömےEUUUUUUU2e$IHmlcmUaFpmƫ$&ٙm#m6)@@@@ ͳ3mcU63 0* 5Q)$BEUUUUdH$B"! I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ?9?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTb"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZOj#ZR5UDTDGG**?[ZO"TևZ֢Z_hUVkR?I!$HI$$I $BI!$HHI$$I $WfW # }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???^KC^$??C׿0 @)\@?eմ?eմ?eմ??@@@P@P@ ???333333?333333???#~j????333333? 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I$ٙmmm33;miI#mٙfa 0 0mےIUUTj;F1F)m$IF;m$*;evPBI$"'!m9#mmm36fmᙙfvmi30 0F5QVF۶m$(m$DRI"!H""I$ٙTj$"""e$UUUTd!E!A!I@@@@@UUUUAA!R@AAA!AB  I$UUUUUUBUUUUXA"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""~binding site for residue so4 a 500ac1^ 1vbinding site for residue so4 a 504ac5/11vbinding site for residue so4 a 505ac6bz1vbinding site for residue so4 a 506ac7tu1vbinding site for residue so4 a 507ac81vbinding site for residue so4 a 456dc21~binding site for residue so4 b 500ac9[] 1vbinding site for residue so4 b 456bc1ay1~binding site for residue so4 b 502bc2 1vbinding site for residue so4 b 503bc3st1vbinding site for residue so4 b 504bc4~1vbinding site for residue so4 b 505bc5QR1vbinding site for residue so4 b 506bc61~binding site for residue so4 c 500bc7\^y 1vbinding site for residue so4 c 501bc8 1vbinding site for residue so4 c 502bc9Y1vbinding site for residue so4 c 503cc1.1vbinding site for residue so4 c 504cc2ay1~binding site for residue so4 c 505cc3 1vbinding site for residue so4 c 506cc4$%1vbinding site for residue so4 c 507cc51~binding site for residue so4 d 501cc7 1~binding site for residue so4 d 502cc80]y 1vbinding site for residue so4 d 503cc9ay1vbinding site for residue so4 d 505dc1st13ROIf9 fX ??9?"b"eeQ?(/jO#ԍiQD֨5Z֨?jhhG֨5ZZQ?(j*T#R""TUTEDD*#[ZOTQTkKj֭jGI$$I $BI!$HI$$II $BI!$WWBWfWW#?"NѪ }binding site for residue cl a 439ac1.G 1~binding site for residue so4 a 440ac2^a| 1vbinding site for residue so4 a 441ac31vbinding site for residue so4 a 446ac8d|1vbinding site for residue so4 a 447ac91vbinding site for residue so4 a 448bc1Eo1vbinding site for residue so4 a 450bc3E}1}binding site for residue cl b 439bc4-F 1ubinding site for residue cl b 440bc51ubinding site for residue cl b 441bc61~binding site for residue so4 b 443bc8 1vbinding site for residue so4 b 445cc1c{1~binding site for residue so4 b 446cc2]`c{ 1?333333?333333?333333???????@???AMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGR3-phosphoshikimate 1-carboxyvinyltransferase; chain: a, b; synonym: 5-enolpyruvylshikimate-3-phosphate synthase, epsp sy epsps; ec: 2.5.1.19; engineered: yes__EEEEB_____EEEE_____HHHHHHHHHHHHH_B_EEEEE_____HHHHHHHHHHHHG__EEEEEGGG_EEEEE_____________EE____HHHHHHHHHHHH____EEEEE____GGG___HHHHHHHHH___EEE_______EEEE_____B__EEE_____HHHHHHHHHHHGG_B_EEEEE_______HHHHHHHH____B__EEEE_____B___EE__B_HHHHHHHHHHHHH____EEEE__EE______HHHHHHHHG__EEEEE__B_____EEEEEEE____B__EE_GGGHHHHHHH_GGHHHHHHH_B_EEEEE______HHHHHHHHHHHHHHHHG___EEEE__EEEEE______EEEE____HHHHHHHHHHHHH____EEEE__HHHHHH_GGHHHHHHH___B__EE________________________FF___F__________________F______________________F_F______________________FFFF__F_______________________FF_FF_________________________________________F__________________________________________________________________________________________________________________________________________________________F_________________________________________F___________________________________________FFF__________________ "binding site for residue cl a 439.Gac10F"binding site for residue cl a 439ac1F#binding site for residue so4 a 440^_`ac20F#binding site for residue so4 a 440a|ac2F#binding site for residue so4 a 441ac3F#binding site for residue so4 a 446d|ac8 F#binding site for residue so4 a 447aac9F#binding site for residue so4 a 448Eobc1F#binding site for residue so4 a 450E}bc3FENKTVIPHAKGLKGTIKVPGDKSISHRAVMFGALAKGTTTVEGFLPGADCLSTISCFQKLGVSIEQAEERVTVKGKGWDGLREPSDILDVGNSGTTTRLILGILSTLPFHSVIIGDESIGKRPMKRVTEPLKSMGAQIDGRDHGNLTPLSIRGGQLKGIDFHSPVASAQMKSAILLAGLRAEGKTSVTEPAKTRDHTERMLEAFGVNIEKDGLTVSIEGGQMLTGQHVVVPGDISSAAFFLVAGAMVPHSRITLTNVGINPTRAGILEVLKQMGATLAMENERVQGGEPVADLTIETSVLQGVEIGGDIIPRLIDEIPIIAVLATQASGRTVIKDVKETNRIDTVVSELTKLGASIHATDDGMIIEGPTPLKGGVTVSSHGDHRIGMAMAIAALLAEKPVTVEGTEAIAVSYPSFFDHLDRLKSEAENLYFQ3-phosphoshikimate 1-carboxyvinyltransferase 1; chain: a, b, c, d; synonym: 5-enolpyruvylshikimate-3-phosphate synthase 1, epsp 1, epsps 1; ec: 2.5.1.19; engineered: yes__EEEE_____EEEEE____HHHHHHHHHHHHHHH___EEEE____HHHHHHHHHHHHH___EEEEE__EEEEE__GGGGG______EE___HHHHHHHHHHHHH____EEEEE___GGGGG_HHHHHHHHHHH__EEEEHHHHHEEEEEEE_______EEE____HHHHHHHHHHHHHH____EEEE______HHHHHHHHHH___EEEE__EEEE_________EEE___HHHHHHHHHHHHHHH__EEEEEEEEE_____HHHHHHHHHH__EEEEEEEEEE__EEEEEEEEE________EE_HHHHHHH_HHHHHHHHHHH____EEEE_HHHHHHHHHHHHHHHHH___EEEE__EEEE__________EEE___HHHHHHHHHHHHH_____EEEE_HHHHHHHH_HHHHHHHHHHHHHHHHH________F______________FF___F__________________________________________________________________FF__F_______________________FF_____________________________________________F________________________F_________________________________________________________________________________________________________________________________________________________________________________________________________F_FF_________________________________#binding site for residue so4 a 500^_zac10F#binding site for residue so4 a 500ac1F#binding site for residue so4 a 504/1ac5F#binding site for residue so4 a 505bz{ac6 F#binding site for residue so4 a 506tuac7F#binding site for residue so4 a 507ac8F#binding site for residue so4 a 456dc2F3ROI_a3RMT_a  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~@@0K; S@ 3-phosphoshikimate 1-carboxyvinyltransferase; chain: a, b; synonym: 5-enolpyruvylshikimate-3-phosphate synthase, epsp sy epsps; ec: 2.5.1.19; engineered: yes3ROI3roi P 21 21 21B(BC ???abab????????? AAHHHHHHHHHHHHHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW9faa3ROI_aali_out ff ffffff ffffff ffffff f fffffffffffff ffffff ffffff fffffff ffffffff ppppffff pppppp!ffpppp fffffffff ffffff fffffff pppff fffffff fff ffffffff ff ffffff ffffff fffff, pfpbb p fffff ffffUf ffffff  ,fffffffffffff fffBfff ,ffffff fffffff fffffff ffffffff fpppppmffff %pppp , fffffffff fffff fffffff ppppf fffffff ffff fpppp!!mmmmpfp pp ffffpp fppppp pm!mfff paacl'eeXcl chloride ionaaso4saaso42s]q=aaso43s header aaso44sart ... aaso45s aaso46s` aaso47sFT`aaso48saaso49saaso410saaso411sNbbcl'eeXcl chloride ionbbcl2'eeXcl chloride ionbbcl3'eeXcl chloride ionbbso4sbbso42sbbso43sbbso44sXbbso45sawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76 _ala  _met   Easp  Etyr ! " Egln "!#%*"$#"&%'&()''+ Ethr#+*,.1+-,+/0..2 Bile,213592432675856: _pro3:?9;=@:<;:>=?9>A _ser ;A@BDFACBAEDG  _gln BGFHJOGIHGKJLKMNLLP  _glyHPOQSPRQT  _leuQTSUW[TVUTXWYZXX\  Eser U\[]_a\^]\`_b  Egly]bacebdcf Eglu cfeginfhgfjikjlmkko Eilegonprvoqpostrursw _cys pwvxz|wyxw{z} _valx}|~}~} _pro~ _gly _asp Hlys  Hser  Hile Hser  Hhis  Harg  Hala  Hval Hleu Hleu Hala  Hala ! Hile" _ala # Bglu $ _gly % Egln           & Ethr ' Egln ! "( Eval"!#%("$#"&'%%)) Easp#)(*,0)+*)-,./--1* _gly*10241325+ _phe 25468?576598:;9<9=:>;><=@, _leu6@?ACG@BA@DCEFDDH- _metAHGIKOHJIHLKMLNMP. _glyIPOQSPRQT/ Hala QTSUWXTVUTY0 HaspUYXZ\`Y[ZY]\^_]]a1 HasnZa`bdhacbaedfgeei2 Hleubihjlpikjimlnommq3 Hala jqprtuqsrqv4 Hmetrvuwy}vxwvzy{z|{~5 Hvalw~}~~6 Hser 7 Hala 8 Hleu9 Hgln : Hgln ; Gmet< _gly= _ala > Eser ? Eile@ Egln A EvalB EileC Gglu D GaspE Gglu F _asn G Eile           H Eleu I Eval J Eval !#& "! $%##'K Eglu !'&(*/')('+*,+-.,,0L _gly(0/130214M _val14357:46548977;N _gly5;:<>;=<?O _met<?>@BF?A@?CBDCEDGP _thr@GFHJMGIHGKLJJNQ _glyHNMOQNPORR _leuORQSUYRTSRVUWXVVZS _gln SZY[]bZ\[Z^]_^`a__cT _ala [cbdfgcedchU _prodhmgiknhjihlkmgloV _proiotnpruoqposrtnsvW _glu pvuwy~vxwvzy{z|}{{X _ala w~Y EleuZ Easp[ _cys \ _gly] _asn^ _ser _ Hgly` Hthra Hala b Hilec Harg d Hleue Hleuf Hser g Hglyh Hleui Hleuj Hala k _glyl _gln    m _pro        n _phe  o Easn $! 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