x3.6-1h /data/swissprot/ 3L07.pdbdupa 1B0A.pdb#[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase, Putative Bifunctional Protein Fold From Francisella Tularensis.[/h3] [p]J.Osipiuk, N.Maltseva, R.Mulligan, J.Hasseman, W.F.Anderson, A.Joachimiak[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3L07" target="blank"]3L07[/a] [small](deposited on 09-DEC-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1B0A.pdb3L07 a_3L07B1  1B0A3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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P(~e{ld,.9wΞ`0T:þTUU}.s^xxxYzG1rm}훨K q:\UlDQ/7glkG) QW&H܌uRG=|K 2a8Ɩ-[x뭷 o%\l:{9" SOH8??beNͦK7o3,;NX<|\./5ϸWq)3LÍpгGyq)JB d SL׿ W\k?Ϙ1c(++78OW k_K~ 6I1џ5e)Z'L7Bp?>5xzA1bsՖ(e8.7b|h7?I3 CĉYre/]{hF]],YdPw]m+Ȋ@k҆'$J*|DZĬv%K=ayȲ0q5:t{ϛ\:'A -AjAf_ZOЃCuVy:jihѽ}́#;ز%M?e֥}d[2jCCPII./_@qqqڭ%쳧Jԗ;~|rqǝmos7ŭpS4ILp:~p>oʲ"p:BVR/~կxƍڵko'݇oY̟?_}b񢢢BlذAp= GE]dO'Dѣ::XVMsz}q Һi<5=cً.e邋e[w¶=RgTfIg]K(<ӻl2xL׹x<ˣz`.Kmy>(^t'$3wnضYf3+]B|"t=Psc;־O/ؗ^z_|`0H(" F٠egUôt! i= /3m׌ލ@nK/e# S$^YJX6?֬Y! v)--qQ\\̬Y(++RHIydIA3~X*+*`TA9%gs_ 9 6 Gsi4WEtڻ\+i. ]tkb,Onyr|E4r9a_Q^I'1玦0w i XО?Akgyo!O )Fa"d8/ˁ+ cDGS;B|OaW4h5 L5+'_?E Ft'W`LXI#I6 GxTA45$_-1;b{^\Fȓ&<=މ=Y9pdGm̚h4FQUC_0/!#P|Y&A"$dEA*5x<qhΦcϽBĽ2b2o|p“>&+aB)xOO/i,䉏זeU|,KihAݬo'l<p’'>Y[L_zs0jhe㫒FŸ'.y_E|jq6AOTZR)Gx Ypy,Ȳ1lH.HS"!KNXcAB$Ѥ#7)O>ǂIȊssĹN#A!yF6F31B mgic<#H#A!yF6F31B mgic<#H#A!yF6F38/yIENDB`move=1000;blend=1000;1B0A\\_p3L07B1|,, jZjZ_RJOW֯#ZR'*kUZTRJOVQU"$$!B!B!DC:B,U f$D*  UUUUTIUPUU$""I$!@UUT$UUURI$$UT$DDI$ I$IB$DD$$I$I*(*$DDDIUUUURDDDHTAUTHI$BIUURI$ I$DDI$ """I%URH$HBDDI""HUAI$DJ vbinding site for residue po4 a 501ac11vbinding site for residue imd a 503ac31vbinding site for residue edo a 506ac6 1vbinding site for residue edo a 507ac7_x1vbinding site for residue imd b 502ac21~binding site for residue edo b 504ac4 1~binding site for residue edo b 505ac5j 1vbinding site for residue act b 508ac813L07B ,,q ?93 **WQU_ʊTU)?Z5RZ**UGZ'TOmjT֫S֩I_֥Mj֭Z??DHHBB$$!B!W#93 vbinding site for residue po4 a 501ac11vbinding site for residue imd a 503ac31vbinding site for residue edo a 506ac6 1vbinding site for residue edo a 507ac7_x1vbinding site for residue imd b 502ac21~binding site for residue edo b 504ac4 1~binding site for residue edo b 505ac5j 1vbinding site for residue act b 508ac81?333333?333333?333333???????@???VŽV$??5 \O)@E?v?v?v??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4?PNG  IHDRc IDATxy|ՕUՋZjɖ%[x ,K2 eB$$$$$ a B!%@lvlxdڥ޻ZRK%y?ꮾUuԹ;HƕMb /)1 PH,8)@Q^yl">o.(.^F pQ\XD<9 qH,8&MtyDbA4=NT bV].IeH4f#j_$<2xC7[6 Mo:s769y:g$D5Zܲh% 5$QY6 8h`Hίi1T5R~@:uFBtMG` p?$t U Da ϧ_> YV@AL  E:-ZM|~!Ɛ]k58[ZC`hBe%m]GOux5%˓W 0hO;n4OUtj*0q,<, LjB"]dgryOܣj<$I2}'{çVLZ@gF\SѴG֤v{FC'_15EaK~tS)<w8+GPQ4]%qE5[оEjSOL?UU /L米jS\TB(Ox_4BoӖ\sQ/<5s>$/Ά~NQa ]44}rb:P;M L0qخ93aLt#ɩh=As~_rj&L׶SbNǗOKk8zLXĄ0O$32e:/9"]ISrL$ ?yGL@\eA-2:iKbַپg o_hlO7c'r9_/{®UVT,+Ȓ$Iab a0M4ȒaؙY6k )FŅaH` !c8OJsesgi87Ȯ =>bkXvݠ5N\0 7.pg0p)#N0dvQe!K9S;a*.EO8ڜ:QhH~D-wҰ%,,O615 E˰mYEyaCIchj4CāsP+fNY5l+j#R|eC9ʊ~"!7DŽl+B[W#mY#׹48AM8LZKlcjjKD80:5dBzV}qxo;PcAΣv!8{h@B4H6X*w`v$!2ۑ~L:0PFxޓڕR"M?,)u5yPs #& ?a;O:Ý L`-T֤`l;?Z;PM\<\].W||dŅ"+H/+ ǽGߣZul_6?~짦rnctuƒ:+QI哟SB~N _XC<9wn1S$ 24I ,DoYq;TJko!PBd'KqSWNCDw  gIL8NOa  %mm4aYU%$IA!Q=v^kR67x?2 YlC ۗeryuCu4#=G $ILLaޘlG󧭱%cccrdI!Ǘדc2qy:-H0ae2Ae9 dyrp<#ܦ78#If$i+Bwh{]$ M5Ox~R]]W_}s4Ivvʪ!MZa>;L¥)b!˛?ʮpɖȖXRo an[R£igC85kؼy3<ȰsFR4=dYN6#>c++Bd J)-b:yc4h L[qHvHFF$+ EqQ_*865³fNcƍ< `UӐeXsL3Ԍ8Ms!+fLtC'AIXjϣ]6Y1T//Og"xb޳ڸq#͆/=nBVYqrtB4C6 2IJ0|v{kd|[E4#nD0|@"9i;xF(J3裏k{Is$ouL7O; -'b.6$I&re?P;'YGSaN[|Ht7cs=KW굍K8x?яS<3i7+xv{A000}h3H$9O7Aj9-DSaf,E74ʋ'P=v磽oP^2 =6]0N>d/s{۹Gw=Q_"+(9ϱuvyO..m 9 B=f,EBBQ\L7J$1dq% .[ouw}۷?).ʯ0dYF5r} 𘵨\QK'f.#RQa6|5{tXW71e[aumwMb94ol֤n~s=d-E$V/Oas󲋝=VKS;# \R* Ҷ;?؊'I$ lg(ۧ|z80tZLwd잙 +l S;"r|ih灷 RR#1tɽDn]w-LYQRcYGxRZ.9{XbA Kjj˂R+29Akg{X%j gg姴_>Vjg%>0)x9 ¼rf6/H'sPl7 M{Ht40vFO$E -ut[im?Fnn^Y`Ε+43GsF~Nj3^6ڵ:Hfh4Ԍq׿YgG[Bd }vo=ݦM[nᗿeVۯbG?)TFN,me'My|uxy椹3^˔ )}g9.bz)GhAa 7;f%p0l2Xv1T)ሟ|EQ 1\SO`<,Ӟx;ZPd15-OJ9%/N̛CUhJBÓȎ4M/`,?Wpu9!noiӦ*ĂDp]N-%ӉSO;s++%Gish IpGV[Z Hv;S.[Dwy6˗/dݺ}EEE̞r*P;]G_3-!R9xgjQ՚&XT5Eq;Z'˓îQd#SI00Xd6lp>y8}^^'0o^j2 /lI kN$a6fO>YBtbgv\y/K285-$I`r qḙ;H`͚<ѣ H+cː$9Q$q⇭=eSMQ1x3ؖ'_QZk*$2-r{IUQ(SC/ru `3C<\)%, yʂ~k/ۧM\B: A{%Kr()+B׵x]px !w[yξǁ|\=* lnL$.OTĔ΂$>OS!Ɩ8q$y`+<ĖtS! cAlxJ!)Lnn%B\dpcsYRz99YN!g%IxGU)+7Gka>~knƖ&a35y糯$Jv##C6*+ SذtS^:B:?"7p+n=.ཝ/8e葇P74\Z!Œ/a7,,oʴK}v즀~Ykec p} XJ*J&p{zK?NiKŹrr&{ @Ja<.Ń$K)NlΣ,w>{o Be}AVǍO.;vGWřϝyV3G%-+z=YޜDNd#. 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Ȳ?FqAENY'_e׷a9)9RY֎3iPQ;#%_XkxN|x<>DĵHY$Vĩ#0U%°vmk{ Rܸ\n\h,ġ~͘jƖ"A0au$jCR ВY(.J0A0܁?NanGMbD4=Κfu4]%dB4.7xUU2Ҿ+_KZ *g٧q=4O" J,#W,-K gKHqwV;2s&v̜1a,bjcm|M0/gg"Yr%.ٍ?NWF>vϚtaMJșKAGɷ,nۃPU3ߪ[ Ɣ~}Q~yRƌԈ 7~<ΘCIr|BlM̚ۇ@(܆ɌE:? !x UE"|G2Ջ{ϡ0묓f"m1Fq-f$^['#ĵf~Oh=c^a%oA]~ںٱMZ{TOjM:$$ɞϘl/\~aNaW7kYT0DXP3fcKk%Kds3iU_0ttԛ|ji1Zvnlb.n~]!: ĞH05 A$fBЉĂ0i]"*6%!SKB4j0IgC`HiK$FPƐ]mX tP7_1բG5kX6<9e}>cKkGVxogr置ǑP]PdE>Öqkyrw51UJZgݩ7:xrs.t]#/<6/ЙI9CGQ g^Ͽ6: `c\d8qg,R@"~ZX3ǕEe,/@D ")/Bdbjv`+"΁~3"5iPQA74Uhj,)wODTqgJa'JQRDKMox;$[>8c'8,)H3/vظb뼣u #[& ɱ CG: gbϬ<)]d$$ǍWgOYG ZL1*gr^چБ ! d9zk >vB" & y-_0D\!˛A74]yc׶W1nOJ{}\X80fuҖ bckIW{];YݚT?EWPWf wutl9̧H U3"M\ط+fgXz5.ˌ鷉|$Ig93GC d5ܩY%HzO,N,%ndE1X+K IE?~{leLOpAs{ܥS\i. ͥ?xڔ6}7a,+G tqᑐ(+?eRkV.BNv :0̙)fog`8n $#9$9+Ȓ±u]y׉[^o]pYѥLM 74PAn)/-rą WtܚWSahDHeۈƷ鎦CTW̰ޙC:anZNk*t T9R`֪@"{ :}\nHj1Yw>رvk\[ a.`+k=0Q ,f2z\BN4FdI})ɲm͞rʀkrrɒYS5)U /3rZ h/]n&ă!KcKG0bԆ0bl" P;l9M&p<\KXkkC0v`eys9L*(-uШ#D*)I5c/6ԓ.jb=p++Y֎mX4 'rު5X1w*u~n,a=EcۊZj_#gS+RH2drI4fYjm.XmZyy' kLذRHI]LRttÅKvj^Oc Q[-Z`ؼc`y rLm6!n*LN afx}F CշX%[;  m$1]EQ~c.rǞ{a'yb(ri򧍿C2ub.OJ AL 'c@7Doato)˭(^74\qa`P0BH ðR?&,ff25]6.VQdF}ӞTqJ':&r5'x[$o&PQt]C;zz/\xٿkNfR|[O\yv/a{ IENDB`move=1000;blend=1000;1B0A\\_p3L07B1|,, jZjZ_RJOW֯#ZR'*kUZTRJOVQU"$$!B!B!DC:B,U f$D*  UUUUTIUPUU$""I$!@UUT$UUURI$$UT$DDI$ I$IB$DD$$I$I*(*$DDDIUUUURDDDHTAUTHI$BIUURI$ I$DDI$ """I%URH$HBDDI""HUAI$DJ vbinding site for residue po4 a 501ac11vbinding site for residue imd a 503ac31vbinding site for residue edo a 506ac6 1vbinding site for residue edo a 507ac7_x1vbinding site for residue imd b 502ac21~binding site for residue edo b 504ac4 1~binding site for residue edo b 505ac5j 1vbinding site for residue act b 508ac813L07W ,,q ?xUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ U*_UUJ*T*T*Z֨?_Z֩?(֩TkUZiTQj*5(VRUT$!!!!"BBBBBHWWW Wf#O>UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP vbinding site for residue po4 a 501ac11vbinding site for residue imd a 503ac31vbinding site for residue edo a 506ac6 1vbinding site for residue edo a 507ac7_x1vbinding site for residue imd b 502ac21~binding site for residue edo b 504ac4 1~binding site for residue edo b 505ac5j 1vbinding site for residue act b 508ac81?333333?333333?333333???????@???C$C$??= ?4@@ ?@]?@]?@]??@@@x@x@ ???333333?333333???#~j????333333? 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B/ffAA\)AGAgABAiA AffAPA|(A A33B!BGAAA =A=qAQA_A(AA{AhQA=qAAمA =A(AA =BGBBAԸRB33A=qBAA(BA A B\A(BB(B HA B\B BD =A =AzA(ApB!HBBAB =BA{A=qB\AHB HA(AzA\)AB AAAzABffAGApA=qApA(BpA=qAffB =B RA(A B=qB6AA AzAظRAAAABB GB{AB =BBQBB?GAzAB pA{A(A33AQBRA{AA\B{AAQB pB# B6zBABB=qB=qAۙA A33B  F1F2F3F4F5F6F7                                  f f   f                          f f f        f U                   f f      ,  f f f f               f f f f f     f f f f f f f f               U f f f           B f f U f f f               f f f f f f f      f f f f f             f f      f f f f f        f f f     f f f f f f f f      f U f f     f f f    f f ,  , f f f       f f f f   f f f f f f f f                   f f f f f   f                          f f f        f f                   f f      ,  f U f f               f f f f f   ,  f f f f f f f f               f f f f           f f f f f f f               f f U f f f f      f f f f U             f f      f f f f f        f f f     f f f f f f f f      f f f f     f f f    f f    f f f       f f f f   f f f f f                       U #binding site for residue po4 a 501ac1 F#binding site for residue imd a 503ac3F#binding site for residue edo a 506 ac6 F#binding site for residue edo a 507_xac7 Fz#binding site for residue imd b 502ac2 F#binding site for residue edo b 504ac40F#binding site for residue edo b 504ac4F#binding site for residue edo b 505ac50Fhi#binding site for residue edo b 505jac5F#binding site for residue act b 508ac8 F@KH@@?AA@@?AAA A@@?AAA0@@?AAA A0A@@@?AAA0@@?AAA @@@?A@@@?AAAA A APAPAA@@?AA@@?AAA A0A@@@@?AAA@@?AAA APA@@?AAA @@@?AAA A0A@@@?AAA APA@@?AAA AP@@@?AAA APA@@?AAA A0A@@@?AA@@?AA@@?AAA AP@@@@?AA@@?AAA AP@@@@?AAA AP@@@?AAA A0A@A`ApA@@?AAA APA@@?AAA @@A@A`@@@?AAA @@A@A`@@@?AA@@?AA@@?AAA0@@?AA@@?AAA AP@@?AAA APA@@?AAA A0A@@@?AA@@?AA@@?AAA0@@?AAA0@@?AA@@?A@@@?AAAA A @@@@?AAA @@@?AAA AP@@?AA@@?AA@@?AAA APA@@?AA@@?AAA A0A@A`ApA@@?AA@@?AA@@?AA@@?AAA APA@@?AAA AP@@@?AAA APA@@?AA@@?AA@@?AA@@?AAA AP@@@@?AA@@?A@@?AAA0@@?AAA @@@?AA@@?AAA AP@@@@?AA@@?AAA0@@@?AAA@@?AAA A0A@@@?AAA AP@@?AAA AP@@@?AAA @@A@A`@@@?AA@@?AA@@?AAA AP@@@?AA@@?AAA AP@@@?AAA A0A@@@?AAA A0A@@@@?AAAA A APAP@@@@?AAA A0A@@@?AAA0@@?AAA @@@?AAA AP@@@@?AAA A0A@@@?AAA @@@?AAA @@@?AAA @@@?AA@@?AA@@?AA@@?AAA @@A@A`@@@?AA@@?AAA0@@?AAA A0A@@@?AA@@?AAA AP@@@@?AAA A0A@@@?AAA AP@@?AAA A0A@@@?AAA AP@@?AA@@?AAA @@A@A`@@@?AAA0@@?AAA @@@?AAA APA@@?AAA @@@?AAA @@@?AA@@?AAA0@@?AAA A0A@A`ApA@@?AA@@?AAA0@@?AAA APA@@?AAA AP@@?AAA AP@@@?AAA APA@@?AAA @@@@?AAA@@?AAA @@@?A@@?AAA A0A@A`ApA@@?AAA @@A@A`@@@?AAA AP@@?AA@@?AAA @@@?AA@@?A@@?AAA APA@@?AAA A0A@@@?AAA AP@@@@?AAA A0A@@@@?AAAA A APAPAA@@?AAA @@@?AAA APA@@@?AAAA A APAPAA@@?AA@@?AAA A0A@@@?AAA AP@@@@?AAA@@?AA@@?AA@@?AAA AP@@?AAA APA@@?A@@?AAA0@@?AAA A@@?AA@@?AAA A@@?AAA A0A@@@?AAA APA@@?AAA AP@@@?AAA A0A@A`ApA@@?A@@?AAA0@@?AAA APA@@?AA@@?AAA AP@@@?A@@?AA@@?AAA A0A@A`ApA@@?AA@@?AA@@?AA@@?AA@@?A@@?AA@@?AA@@?AAA @@@?AA@@?AA@@?A@@?AAA APA@@?AAA AP@@?AA@@?AA@@?AAA AP@@@@?AAA A0A@@@?AAA A0A@@@@?AAAA A A0A0A@A@@@?AAA @@@?AA@@?AAA APA@@?AA@@?AA@@?AA@@?AA@@?AA@@?AA@@?AAA @@A@A`@@@?AAA APA@@?AAA A0A@A`ApA@@?AA@@?AA@@@?AAAA A @@@@@?AAAA A A0A0A@A@@@?AAA APA@@?AA@@?AAA @@A@A`@@@?AA@@?AA@@?AAA APA@@?AA@@?AAA @@@?AAA0@@?AAA A0A@@@?AAA0@@?AA@@?AA@@?AA@@?A@@?AAA APA@@?AAA AP@@?AAA @@@?AAA A0A@A`ApA@@?AAA0@@?AA@@?AA@@?AAA @@@?AAA A@@?AA@@?AAA APA@@@?AAAA A APAP@@@@?A@@?AA@@?AA@@?AA@@?AAA0@@?AAA @@@?AA@@?A@@?AAA0@@?AAA @@@?AAA @@A@A`@@@?AA@@?AAA @@@?A@@@?AAAA A APAPAA@@?AAA0@@@?AAA@@?A@@?AAA @@@?AA@@?AAA @@@?AAA A0A@A`ApA@@?AA@@?AA@@?AA@@?AAA APA@@?AAA @@@?AAA APA@@?AA@@?AA@@?AA@@?AAA0@@?AA@@?AAA AP@@?AA@@?AAA AP@@?A@@?A@@?AA@@?A@@?AAA AP@@?AAA A@@?AA@@?AAA0@@?AA@@?AAA AP@@@?AAA A0A@@@?AAA A0A@@@?AAA A0A@A`ApA@@?AAA @@@?AA@@?AAA A0A@A`ApA@@?AAA AP@@@@?AA@@?AA@@?AAA AP@@@@@?AAAA A APAP@@@@?AAA A0A@@@?AAA @@@?AA@@?AAA @@@?AA@@?AAA A@@?AAA0@@?AAA A0A@@@?AAA0@@?AAA @@@?A@@@?AAAA A APAPAA@@@?AAA@@?AAA A0A@@@@?AAA@@?AAA APA@@?AAA @@@?AAA A0A@@@?AAA APA@@?AAA AP@@@?AAA APA@@?AAA A0A@@@?AA@@?AA@@?AAA AP@@@@?AA@@?AAA AP@@@@@?AAAA A APAP@@@@?AAA A0A@A`ApA@@?AAA APA@@?AAA @@A@A`@@@?AAA @@A@A`@@@?AA@@?AA@@?AAA0@@?AA@@?AAA AP@@?AAA APA@@?AAA A0A@@@?AA@@?AA@@?AAA0@@?AAA0@@?AA@@?A@@?AAA @@@?AAA @@@?AAA AP@@?AA@@?AA@@?AAA APA@@?AA@@?AAA A0A@A`ApA@@?AA@@?AA@@?AA@@?AAA APA@@?AAA AP@@@?AAA APA@@?AA@@?AA@@?AA@@?AAA AP@@@@?AA@@?A@@?AAA0@@?AAA @@@?AA@@?AAA AP@@@@?AA@@?AAA0@@@?AAA@@?AAA A0A@@@?AAA AP@@@?AAAA A APAP@@@@?AAA @@A@A`@@@?AA@@?AA@@?AAA AP@@@@?AAA@@?AAA AP@@@?AAA A0A@@@?AAA A0A@@@@?AAAA A APAP@@@@?AAA A0A@@@?AAA0@@?AAA @@@?AAA AP@@@@?AAA A0A@@@?AAA @@@?AAA @@@?AAA @@@?AA@@?AA@@?AA@@?AAA @@A@A`@@@?AA@@?AAA0@@@?AAAA A A0A0A@A@@@?AA@@?AAA AP@@@@?AAA A0A@@@?AAA AP@@?AAA A0A@@@?AAA AP@@?AA@@?AAA @@A@A`@@@?AAA0@@?AAA @@@?AAA APA@@?AAA @@@?AAA @@@?AA@@?AAA0@@?AAA A0A@A`ApA@@?AA@@?AAA0@@?AAA APA@@?AAA AP@@?AAA AP@@@?AAA APA@@?AAA @@@?AA@@?AAA @@@?A@@?AAA A0A@A`ApA@@?AAA @@A@A`@@@?AAA AP@@?AA@@?AAA @@@?AA@@?A@@?AAA APA@@?AAA A0A@@@?AAA AP@@@@?AAA A0A@@@?AAA APA@@?AAA @@@?AAA APA@@?AAA APA@@?AA@@?AAA A0A@@@?AAA AP@@@?AA@@?AA@@?AA@@?AAA AP@@?AAA APA@@?A@@?AAA0@@?AAA A@@?AA@@?AAA A@@?AAA A0A@@@?AAA APA@@?AAA AP@@@?AAA A0A@A`ApA@@?A@@?AAA0@@@?AAAA A APAPAA@@?AA@@?AAA AP@@@?A@@?AA@@?AAA A0A@A`ApA@@?AA@@?AA@@?AA@@?AA@@?A@@?AA@@?AA@@?AAA @@@@?AAA@@?AA@@?A@@?AAA APA@@?AAA AP@@?AA@@?AA@@?AAA AP@@@@?AAA A0A@@@?AAA A0A@@@?AAA A0A@@@?AAA @@@?AA@@?AAA APA@@?AA@@?AA@@?AA@@?AA@@?AA@@?AA@@?AAA @@A@A`@@@?AAA APA@@?AAA A0A@A`ApA@@?AA@@?AA@@?AAA @@@?AAA A0A@@@?AAA APA@@?AA@@?AAA @@A@A`@@@?AA@@?AA@@?AAA APA@@?AA@@?AAA @@@?AAA0@@?AAA A0A@@@?AAA0@@?AA@@?AA@@?AA@@?A@@?AAA APA@@?AAA AP@@?AAA @@@?AAA A0A@A`ApA@@?AAA0@@?AA@@?AA@@?AAA @@@?AAA A@@?AA@@?AAA APA@@?AAA AP@@@?A@@?AA@@?AA@@?AA@@?AAA0@@?AAA @@@?AA@@?A@@?AAA0@@?AAA @@@?AAA @@A@A`@@@?AA@@?AAA @@@?A@@?AAA APA@@?AAA0@@?AA@@?A@@?AAA @@@?AA@@?AAA @@@?AAA A0A@A`ApA@@?AA@@?AA@@@?AAA@@?AAA APA@@?AAA @@@?AAA APA@@?AA@@?AA@@?AA@@?AAA0@@?AA@@?AAA AP@@?AA@@?AAA AP@@?A@@?A@@?AA@@?A@@?AAA AP@@?AAA A@@?AA@@?AAA0@@?AA@@?AAA AP@@@?AAA A0A@@@?AAA A0A@@@?AAA A0A@A`ApA@@?AAA @@@?AA@@?AAA A0A@A`ApA@@?AAA AP@@@@?AA@@?AA@@?AAA AP@@@@@?AAAA A APAP@@@@?AAA A0A@@@?AAA @@@@?AAAA A APAPAAWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW___W_______WWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW__WW______WWWW__WW_______WWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW_WWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW3L07 a a 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 b b b b b b b 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 b b b b b b b 3 3 3 3 3 3 3 3 3 3 3 3 3 3 b b b b 4 4 4 4 4 4 4 4 4 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7 a a a a a 8 8 8 8 8 8 8 8 8 8 8 8 a a a a a 9 9 9 9 9 9 9 a a a a 10 10 10 10 10 a a a a c c c c c c 11 11 11 11 11 11 a a 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 a a 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 d d d d d d d 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 d d d d d d d 15 15 15 15 15 15 15 15 15 15 15 15 15 15 d d d d 16 16 16 16 16 16 16 16 16 17 17 17 17 17 18 18 18 18 18 18 18 18 18 18 19 19 19 19 19 19 19 19 19 19 19 19 19 19 a a a a a 20 20 20 20 20 20 20 20 20 20 20 20 a a a a a 21 21 21 21 21 21 21 a a a a 22 22 22 22 22 a a a a e e e e e e 23 23 23 23 23 23 a a 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 240K; &4?bifunctional protein fold; chain: a, b; synonym: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase; ec: 1.5.1.5, 3.5.4.9; engineered: yes3L07B13l07 P 21 21 21BBB???ab??? AAHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW,aaY ff ffff fUff , fffffffff ffffffffUfffBffUffffffffff fffffff ffffffff fffffffffUff fff ff, ,fffffff fffffffffa bb ffff ffff ffff , fUfffffff , fffffffffffffffffffffUffff ffffUff ffffffff ffffffffffff fff ff fffffff fffffUaapo4s aaimds  > h>Ximd imidazoleaaedo` = = Xedo1,2-ethanediolaaedo2` = t= Xedo1,2-ethanediolbbimds rt matchXimd imidazolebbedo` Pirs> [<Xedo1,2-ethanediolbbedo2`  [index=Xedo1,2-ethanediolbbact` d wire <Xact acetate ionawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44