=3.6-1h/data/swissprot/ 3Q94.pdbdupa 2FJK.pdb%?[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]The Crystal Structure Of Fructose 1,6-Bisphosphate Aldolase From Bacillus Anthracis Str. 'Ames Ancestor'[/h3] [p]K.Tan, M.Zhou, K.Kwon, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3Q94" target="blank"]3Q94[/a] [small](deposited on 07-JAN-11)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  2FJK.pdb3Q94 a_3Q94B1  2FJK3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iￌ JzyBJG?WO ,U7,w`ٲZ7x- DU??UrV^z)\`'`[>-4R"bt1 xo8PNu:R32դ G0v#?cp%ȋ456"_%}Ņ4 35M#51ǁd`>`Pxk]P'ߺ!CVqƂ~pFf9x%k-ϝI*3nNu> 88wxquߣ|<+"׹u:RfjM+y1ҐDR/7"NvVzS'S"Uiy'<p`'7fҀ"rӓ~~؟S tGDwh֊-;ƎMf@>p \y, H3Yk42;&wss7X:FTƙL|O9~xd+}c'^Өؠ27h֊SGldbg6SA)Ԭc QOGT'()ܔ sOM:i R1Ičf8LfrPY!/,hP8\1t{YE9^)#btD-*)6ckbR?C)B*b1fsfݩ`Pp>׹\ǝ7onJDlj_!S{u!@)Q$gd2Fu8'KCfK+9*iܔ 38fU155»^eʠ׻c2ׯ:51EA7{ч#։sp~]m 6]9?Nos:P;]xn˲,,@qt:^#nڙ<9[kuZq>C#Xh\ƼxlϹL%:CV{oKc(d Nsa2;ٵ6R1<-/gmƪȶkx27#Ņ|$ms L Fv ]l9ѧ#?g)߬ -u.pC;lY]0 !?}]oFf%<Y+j8KFAؔ9ȩN7n^us]]&~y1.ߨ{ f໼xTu߻l9Nu,]1G"16*1ڍ}) Y\O-9-7Ņ t3ۀх7aR!߃vjDv;8IT?6]gV8l%o9d9t4SQI0m{ [=dKm4:vѹ&Khӭ?N@CˮmV[9}D͖"?_ÎM2|s$wnIɴT]ww7g-7bs5OQ 3݉ӌF8=OPnt=ԮMN_8rhv"kճ;wauoA:"9O}ql{iz Kt܋^l4ѫxm W=5)}icv0#\ ͟;6SZ%:nצ|`m{qn͋!t;!j%΃\oB[W5 jj~jvmӦ^@|O>!zzKm=By~wVTwB@o69lgAv͑/r81Ŵ˷:gOcw|%"]ޟ2ҝ.;ёhؼ5')*m펍?~>77"ϟf62 (~Rl,$z2D)x}l-3dz#Νӫ]zx=Bx^y a&+#+(߼2M[rY+,:~|| >˳1)e09-?^ aBtlxYg/a58ngY.=IAcg4>ݢ? 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MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES13Q94B1I6 ]6| WUUkUUWZjֿUUUU֪խUkZUZ֪Z֫Z֯U_֪֪UZVUUj֪UWWj]ujZjUUEUPUUUU_֫jZ֫WjZW_ZjU_j֪UWjjUZ_UZkWjjZUUZW֫ZWkUZ֪֫UZխV*UZUkU֫_ZjjU__UkUZ֪V_u֭֯j__Wj֫UUjZUUUZ]jZj֫ZjUUQUTUUUW n?WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???$??G;@@ GrH@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residues;PNG  IHDRc IDATxwx[?ڲe8ރ@¦2J 4JPV @Ki-m)(eS(BBHNl{ʒeIPb#$$vOty{ν~s9y |c78d|g~ ϛw3s9sՔ< 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Bu~C}0;Tr912,Z646>Z-2 2Q*IO:aL ϶m3x2@T } $߾ f66euk#KCy4ba?*#*;--2֭hx&s'O{%>:`nl @&STHT44<Œ%# U~V>۳51g$_**:OLO'LsE@<5GqQo,]e46պ-jc qo[v#1*zx]X}QسgpwmNM])P()q"'ᡐ+?;;h4h49D|Y#&S) gÏiqعsi5R7siRWq^o00fOPxQ7)ƌ|c|)i^IENDB`move=1000;blend=1000;3Q94..\ *  C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H   @!gp8SPcGjz:yf1J5yJ1{`Ǹ+R1Խ[=pa (Ş4C(!9Yr` AacѣJ8R ^^rA a@24hYsX搶Ę8#.p=q I @ @9cE1-YYhrGRMyIhslX[XM,5ĘR9j=C9hisVj׹%Z^(-G9rhמ-Iz# bŹ!QJPRp0I9İy8d sJjq@P$1afs C,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding 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*Ey>+v;x=1111$$1$1cBCCCBCO  @!gp8SPcGjz:yf1J5yJ1{`Ǹ+R1Խ[=pa (Ş4C(!9Yr` AacѣJ8R ^^rA a@24hYsX搶Ę8#.p=q I @ @9cE1-YYhrGRMyIhslX[XM,5ĘR9j=C9hisVj׹%Z^(-G9rhמ-Iz# bŹ!QJPRp0I9İy8d sJjq@P$1afs C,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine 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ANc8 HvwFsSh]Ì=3)b+ӵ9oNN\̧Y&|LRsviNU$4g=c P%Եg6a eLH@n09hj.! ]j1Z"+Дn&\&\sjzQM(ȯ + c)sJ^d5v˭|Y}״KG"P)],de~XAW7_,h͛OPr5ѣ\1qy X]CJA9([!@ZφV}|)t혤ˎc"p[gax&ffp\|V1;>X3=YD8{[YgzWehtY" ;_*`2W+/yCydL A^ ;dv`iiA]('.5F 8P(n-bg^qg0z&}3u&cVjoltY̬@F1 ̢0]uXJ箒OY,( /Y|'jE1+o3W:b,Mb6իoزS8]YHƊ CPPp&P\XB+ `A&EA2(R7>f\a8C9Q6wسT`^9 \p{=e ̻b͡ ;XqxA\Hz2HFCX# 0 }fYy4X^'"kIy(I#´b^L@}klѭ'`y6*aqi:,1Zٖ`F00xX#`SK߰75:0껁g̹P pUYεu_db3jڳ|FlXPHB0  Hmj skB}=\{i>l\byz$X:lZ0"ZA1kMV{Xͺݽ`X< W1ɾaHA@^04A_JMVmv9g Qkl;؞b:W`Φ#:d8`@i@Dd6% 5m[]i׿_0g6We3bPƢlJI6r F&6AQaY]zP]C`٭@ b{wRs5AL5%> **Vaūy6f=> XBfq(SUwP̯;VW}W6/(W mkrФ/ 1lS+;;QI6$h3 ' .oƅPhS{g^˩~]),bW͞(g,c7+u(XִfN#EU(WB83ݔyVYk^WT3貓0R8tYY=l$tcY5JOD%8deBԣւfIDE&dI#**&hR)/*g^z@W?۫6pYXnwvstCW7^ֱg+d:*(dPBL @*es4 0Baf= A0CZ?"p-j+H10h*֔+m1Rn~L,(ݔQd܊ 1eh\ȤN:z)$pz/a׌(e#F^)&n1)rӠ]K;,cmePC-6l0v:革Q=ąApͥD%@( %=If-&ٺA}Ilmhmx?- "׌.|R=ZZeU[E39Xsl$Tv@j+|*/R*0*|Kad@\KchE.aiSec#FE{K;W!VNQ- We$+-%zץk>|V' hg#>1pCFEeA~z hi+32M6 Cr)i*;GI5y% h &&%߻'-[OلۍCۨF^SiJ_4芛["Um+(qg[|mb1iX\p^?βxG1q۽mNEH@$U *Ey>+v;x=1111$$1$1cBCCCBCO   44UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@N0Ɗ0ņ4$84$$``$yĘxБD ,40YॖPQEx $ xq(9f4L 8CMmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJK|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@??+2FJKAfffL?p},+3Q94Afff333?p}-?\T$??4@M@@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1MPNG  IHDRc IDATxw|UgܕY a a D8qkUZpkb] ETp0!!MrY?ι77Ʌk=s?|ޟx6p--<}Fc3hlrr4zj=0 ݅aƐc9PZ18{,)5ĸDQbgagdc.q7w?{}F#n+;|ny9w (JLJ_鰍cTԔ24g$ }ʅg_ttg ;|20 ]WQ@KPT@ ATMҞN ~~?o|6Ce{q\* 0t C04DQ"+5' َ/`w(jo{NY%._|Om~Vmˑˑeߪxg}^~7Ǫrbwpl;GStdeQrt'b/U(*x}w{Cos`Md` CGT`w̙UPUIsT|@a;#d$#e 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$cmȲ=\y}:0dZfDQD״ MDž;/TחrĢ)Ue`k׉dV$9Zтޫ>?8GjVy{S$ƧpȪNsexhq'8aVЀD(7 \dq$@SU|>ܹHUq9יٙXE.xA,eaKX,*k׆&EX/Ԇikb]ZZ[rQYXX~ofvYe_2~;}WA8*Y\rbYŶ|nZ,xb0]]( QB.E/h|hN7TI^$$Me5台sO*O4 qQ׋/!ɤ fLyϿ*H4ASI8ǶmZ[e/ߏ=Dbd,ԽԬČm ]qpρwޡe  ׎8MT~3K5{PhP(8uXVA^ӏ44$n~!^v)a2d4_KT_]x'3H=}]CC]BqS4)xl߭LtG#4YSU ˎ/($ʛ`kn뚕+9ƴBꮪQvzmJ[:tO-_QVZ%\q]Czvsn oVMM_ U/@Xl4c±:.}5[ewgS/At4U#iꞴ7bhqB|o[햬krصGS[#܊BO+ۿ&'4t3ɘpU C`U7Oz!-^عyB/-xƋR$'KF㷴v|7#׹5q:z ~+?d17d _bZC7Q@w +oWn]86ma;ks㯚 %xJ+"6`4Ky4@U$i"QOW_KVNr\4 g S|3J+Ui<"C02Ķ+-;Ǝw2[9ͪ誉yo϶-gWTmKџ#`><;kGZ:b)q?{?qFvUg/<t<0,k|F\.m*/Ó;f}{{sXvH4珟>p?N0<@0<5˰uS7_h޽J~.As#d;Z&>.~^O7=)c#cqٖ@cXiZD|"*@!w.C__/H\ض5fuqNdӸz?H,e˸.k,lQ3Ֆ}cgv(nʓo#lBA\QIQ9t-. /gObLdRFkT%"J~2 V_y f{߹&ISuTUn7W6&DcaYpE4_sōR0ɲ <{Kc&nCLPi{)bqx8ݫӳxJbUu>j+~\'P9P[WB8C.EWDgo -pćLϤҔnC!w{>~M4X4J,f8'f Z̷r3_,g$v?.:mb^wTq+ hh 骜/Eb! /x>Ct& s8mh>LCa߾eF0xa4#O4O'gx?o,h ۱[)K±]nڻG_MmB$B@{ ͋{=`Xjh>̳6[x5I?[oOE~=v;j0{?~$W1SPqcxY-6]=%߉gVewXKu1+*;ޱU>{0TE1PTUzmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???$??'.@}Q`7@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2o3PNG  IHDRc IDATxw|\ՙNW,wK12 6nc&6@%$B%MB %e7aw/5$`ph ݀qdVoSn?hdiFI~GS=;ys+>es>}0 1-2(/FBuxN*|],| ۿeo'3!,3}.n_ޣ[B0j,a!źmC>o%sn2 $$I<:eefg7~.-r V=~NGȟ^H20M9tl[xǰ;$u:@Cr*ʨ=Ž1E̜4H@,h bZMDu`Y&K:7niOtDCچ4k"8䉇re7e`8R0u 7zsXɞ#&_m>={_ӕeBi %ض}Lӈ0Ka7Q{ dJ%O2e B/ItieJL !cϘiRO%s']EaA$!!!I/^t;IJL4-%eٿШ$xa͏Nu0,! 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K~&Y{4wXi1XǐT8ݲBB´_; ˮ<dc PFqq"J(qDiD=PP{ޣ9zbyh O㷓YbQXdd{7Yҟ29>B BZ$~۷Oxr*qzPD鑸v9x [Y2fvy0-چ܎ԑ%-MNf.p9uRqƱzjQvƶhQgl9Q6mz<`=.v +Ht$9hpE`ǎܹ3~6$c ev_˃;e WP7]׉(!vX9¸qZ$ (<άkQ49Y|AE@d-]+M0DiŞ(z?A`ܙ nC1L 2 &yB >2"ldIBAS85"iX l(zȉǟݣuctͰvEfWm~ Ez[:Z <֮j'Ihj'w3'!Kr X~ѝL^zpᴯ*$Mǵ5^+VCx>fO2~?۶([&ZHvR(CNf 6ɅcnêI6`9}kV^="yz Ff^nD?}pqM45pe%y&]Ix=~C6T~o`wA” ev{-')i%ϊ&7n$Yӿ?Sե<71-}[S6;uSeo!7CSҤ0PGZikѷMbdYxe,xp{ȲL!<~=^j]:(yϾ!x>BF+8&5vl:"NNy = S1 ,!8cK$fںN WXQ, Ӊ$~CcشcUJK%E3ӛ*c:߁БئeP#-sX{lbhn$S$B2Mx‰[Y[.FUgξKaG gܐ־{]qd ꜴeDF"h\vc:A$NV8Rc e$̝|ږcIƶ[NWQ@WH50J0z<Ɏ PB!`5F G1$[9Vh `ZL\~RD&T-Lim!͘*I22w"yL]4 BNuaYifi4^/#V-\^524K 'V ׳кn{I¼60PaB||9f2:uuIXiB7v]'ϑ$e(a[{d3 9VƓD _9DD j4]a\N4]%4QpU8^yRzֲ̰"-iN%KZ'2e/_P Ce@dPTɺm8L& ˘9" ]wZ01 )EA ?:͠[=|S &Վg˳$uS#4VPIGdKK^ofG3U5H?~[S\t%,\r~wd %' H=r+~MXi˾E ~WVaj#&5ĮC'Jzܓ;^(7^sV٢YYa;/o(.NTW ].~uZa4f ד3|La\'_7wu>`r۹-HD q MTȴzvϿ~Badf꫷R\I/Иe٩+vy}}= ˤfO:G=,2#ih]Js*)D~ #AD havG0O?-EQw1@` >4hBNJe:gGIVSx=~<./1?EUд7]RxH=vu 6~_lr2 2@ebamz8Їȳv!֭;$8 {,9|o?pn9 +(DeL $Q+O)T,{3 䒗՟ܬBn[oTԖj w 04T]-%1r蹸d7#+>R5`4'm&|HdfDS꛺_R<@]I3+H~@嶫~c/ե>,.&/zn5i膊eY\0J;Ŋxr~W8Zx2ȲahDvVaU-{LK?aM<ƓU쥬b/MUXy`yvx Gs000L !LXiyꩵYPH=9dgD4ӗb፜=r:,3Ϥ]X®΢w}<@И% qDӒ/6C_Â.5H,M 5QQ}$,y|^9O}c%Yr˴aLr YJSKs@nV!BXtoBXXd{o+55O>7p jjSzb7gAd2ilgÇ/3\|w&7TU;=UQ5UA)(2㿄E]Δ.bC{ }RdSh]66,I.>DAQt\.߾k8n99 J'ӿ9^`ے,EF &ջ1Nwt+^o_9)3',%×nh}koD,Ͽ%ΚH y";zbcEׯ5cK|+3z" ٳo{bNSnǐI ,,\#H<-nצj4 5D;فX`YwmHOOM[YqYNYvnrʨojUYHC3;V7s{ a:?{n!(Γ=CFs g]!Ex>>> ކ'pO0mIh aR}¢ d7.eӖ!tK~pBxo:$aYV1MIENDB`move=1000;blend=1000;3Q94..a UUUUWUUUUU@UUUU C BjBjF j*5_jj֤֢ T'I*j*?խEF*TU?RkPQQZZԍiZ/Z/TTkP//IEGBTV֪PQQZZԍiԏI  H @AA$IWWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???WO$??7@KnjO@?(?(?(??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3PNG  IHDRcIDATxy|Օ￷nYYƫLf l aq<>#f}a 6C2yBf=dĀ%cjc[^dY[U-hL)UwuUݿ>s=GO!T7.[lR !Bhh^ 唗U`AlbrW$Gڈ'zIqfQƂg[a iƑR"H)mö-t]'T^S>H1bnf"* #K("I B !SLO5y:OFƻI$$Q/|2bzcF#F2ϙO5y:"Żƺ'$1No|5,F]iIDp>z]Dc]ē1VϞpq'k t]ô9]"#{E""tt`nVkPTW:x.' ;v@J(/F=HNewLpD"A,ރs*ȩ"PUY"ɹ)RB(#H$=sJ)RCH Dsou(1 Cj%!*5z21$:>΋%5`юR"O]3, Jr0OVJ)*6j\J< = BRUЅBM%faGGsLdy nx͖i%rYɄJ)0(}||iضpJ0ouH,t\)J)0iٞB4Eo,B*@̧ڰ Si@DSh4ylN=ۊ P=BO3^\uUt]Kxx+'G<#]WUB۶mt4S7nzkU1Y c>b<v%vZeG:ժ4/\o*wg.YY]Y^V]8_>wO#D=XEݗ&K:x"l}~YMHB$͸Z`ǎ? 60cƌD)U.@gQ}i>}0oaM f:/M0cG=Ύl$]=[3<۶yaʻXfM8vl} |p?|r=pڐ|֬Y|;mE|G@8lDIt#!&4R_+Y[ȧz;;Y=N;?ӝ4-D'|8W\q?OXf O>$h"5Mϰ~C,X؊@^ƕH JuYk27n믿HB<(뽧/\s͈F52MAF\?8,X?CEt"2\͘tt@4IrΝ+gW Cfmm-wg @`] 8!>@;pUUW^y%Oii'Ö&[׿&PWWhmmbѢ'xƲ$1i )pU@:q^3V7tT?`edBKR/ yTSQDĄ1SR&/p%zks3={"'f{<pI&cP g4cWx/4"pSzԞ{ˈг>oШi|BRL|lmkymӦM,Z֮姁;č[=q5Wm~I&SsޭX(I5^r?p   hjj***x&48֐w7oΙUV;o-Z$-[&WX'[v  Z[[_)[vL֪UFt݂ ]Yeq˻ޞy}/'.Q] r; s{+,=僟8J\{Gy6qs EIH$‹/f7?Ώ~#8O?/{֗;<Ǐ^Ȫ?29۝ EG+Wݝu9SNȺbFёu}"ϊ+rbu/R GGQgԩ9:P"PP4sfuLsku yZZZZJgpy֭[ǹo%hFSņɸ qF Lk=U @#ߗ|7.H)J_̯.?a֯%KF )/K_iDF;<% TPz'{фF0bi_LNR]1WT7 SO<NR{!x%UJǫVAXuvBKsg44oO!ț\sǣN7'?P!6jBhil%7q.th Qzb:"mi>%UJJpΦi:'f5#yP𡙦*=®=[舴JV"U_:@sF$pZ~Mh WazBQDzhۘVl-m9NA{bZ kiPoϬ0}R+mۜxn/Hk)K)yuSV+/;Cڻ 7eO3-H9dC'iRIV%0@o )mڙq~D],yk-liܫ"^Z]WEj]--218oܔ *DǏtM_f8'Z{`2BoCM躁~N۝ 6*&t,-t[z344VQPS/;Gȹ\ ;!L+ A4ޓVѯu!9uRXi6TIa3+9ulr:nZI5@$¬q$Lx\k/yKL;eP]QvPSБRbI)SnY#`wG[l.&OeV=T6w I]mJYl6$=ܛD"9q$J4m2` hAS{Z?MZC40iK;_N̳(}kvuv{GN 9IH>m8j ^˵H#y3k^_{46H]=}Q4ŊdW.'U8J|?3e]p 0 ݩRʬ]WkuԸN&O/7u^,iz@_|KVhM 5[QZw';+tO8t2#/W#z(Ϣ舴9C]s[v9i)-TOo4ZPߨiȻ.(W97ɫ>AZL^H30},o/08'r"2lp?d4OTjuC- }o Cʆ2y!Sf# f`MշX}ZG,gYIщj {?lM(P0r #;ǐ7ko /yt9?p6˙ضsccQ8|w +zYl;@tg31j4uGr }$–$i&'Ј24wY'=f_@&4wDZ0?*`~1QhyV "˲/ǶRϽ浜ָY}g t8 beNV[퉙SOT>pGM|N!@OP! 0ʩWb&EI1·'n.L;|@E:שcڤ9v~!rRܓ.huۗ˶ұ@5uTWr>N rR Km(|ѝAAeNP ⤹SR"JGɷ4iZ+oŭ_Pn/j/NZ!"s[NDzM8D/(9<>)ZTZHX4{ij9 RHRАXRra6[*p`_,un*3E7z2&ߍ]‡2 Dz W;a y涜i%@Cb;b̵kurE[nD(̚z.2wiH%T|(7ܜ G1QV.6}0kOZo*KMcЃ2&2$G8;˃@meZ~m7'ֵn"qoNL/;mjmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???:2$??>@`=ƻL@?[?[?[??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4aLPNG  IHDRc IDATxԝw3qw;ޫF&X~S4MF1{P@;wUm~5r3{ޟw FL}6`߱v1`6iQçK+ww;F_qÊPT8?7g߂(Y yCiJ=s;)3hn؀H:cB~Dт(v3 ꤬fi3臀EAɏ/Ɲo!'1gx&:ԔLAmFWDIg,+vk+C'j`@#(EQ x O"Z3'v/Yt6ՊiXDD@ n. iy0REnVh:'N}s%lM{W:>@Y^$%# Y!) Dԏ%?2߬ j*j*/4]v4H(ZRNB!?Ff1 kͧ4b.aOJ?1X2zx)Ϟdd QAM9Eh0vloK8+@Cx (lrADIvSuE9I8]"Zq~u%vl,˨ 8R%59Qw()xچS^ \C>;UM2 [IIl6'W.c]nF ƨ;`GEA8=rWDnnm8RapZ;3u̢8?Ց4Ml`@"Z/[G[^F0'?{DڥC~s}kvF8NNdijGʿ$ݓCE4)a䰩 4Uc϶G7$KTD͒t(\vx23:XVI$G jfcZ BBAdYFQeU8QU ds%;?=eWTY.i aBk{"lW1d"vS7 h* ||兘r2%%k{Z0-*`u8HqQNn}IZǿڤnWt. b,0y []Z= -wiLuzXVi)2V)QR A!r &#aycH0Ez4Ud8*Ͳ'33J{3$} MPD4ϝỳаݔۮ1{C}!)<́%Fۅae/_BVevZgւr6Eg1b^ۙӞXLXUUQd)Ei 욆ڕ, z},u-m)$ΘG+v഻Zl|ko㫑u6憝UB'ŕu6!C0 艝=S> !)|MF Ʀ=k"!+)D{̴3Y&ɉC}_9rڼ ,~9 _ѯ IUns&~ϑ(ɦruoGnn>ͫOc[;ext4M3梡S/Z8 'im'`ISՎj碅<=AQZ[liFgK ߖMMx[Jo T8Mmu(9y]Ȋg2?, L^V5inQ2P4}^RSS C444PKX"bGOiW)4dD0Har?R?؉f/%;;lios3܌&z,O&+-;OҧV]8RA8Rݐ(YL`8Fb\cc=T[>?>I$!f>35b59lI8ᗪi39T5faycM+$k*=Ѻ i8Q}fOP-X,^}~Eӧ# ÁnbaZC!`}֯cTJZ* #[pUEV"iZ`*64@N6Uqe24w4{I!vxȲ$Ȳ}7WaĐIQGCUZ;0r;&渾r]Φo4l^eAC*-b_id(۵ӧBȒes89X[Xnl613)o~k1d"EC&!!Zhi#Hܮ4UX085ljBam L*E<2:OBmSǩm<ΐAŌ6Hni'ݓcxG߆aĐ%FP]߷HEIK9t Vo#E&bXV`ȳS8Cen@l##/HJ(A5n7B67il\TV`xc fOaϠ -HШ>!j3a<<٦X宸s5|.UhM{v qSs=B@S/bMATPTY>"ln8^ٓ# "ͽr<-yׂP$$OsJ3Tw$p/::/x(l<:g"0s2r3Ry2#vU@hJV`v2qhOsn3 '~p3gr൏~5 j@'DB@`d 1)'LV>=dIJABR@/؎: acWЀ>a/[]okHKI<(<4c9|Մج4GjᨙPXf> dg <*JN'0xoFNpf|]́nx_ՁN4!)]s\L; _AkWfN\E`4PUMUM_Pl73u "^_kY'z:CިmW-+/~k>%n0oŦ}ۈϯ}={yw򗢠( Q;J2Yzvon3\1CrGhf8Oo1nv4;Ãb5'!9Ѥ{! 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IENDB`move=1000;blend=1000;3Q94G..r UU꪿UUUUIUURA$*?UTTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU2 CCC C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ *U#JBIEF BBR QQ*SUOZ*TTEH)*DT*TJ*U'Z@H HIAI A $WWW Wf#?#OI?BUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???$??G@N@G@?@>`?@>`?@>`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5i PNG  IHDRc IDATxy|TΒH ! ` F hAPkmnVk}>W}ܪU[-,, ȢEB 3˽<;[2L&ykf{9{ eߐ3N6>ݱtA!wv.T=k0kgWBEP5/\'"Hvvu.HL@܊X{BgWONUFgߝtgWO9]y{|gWOʏ#T;FmC%?|gW<ٕP9s1 X-vlV; gu]  I"9$>$uήZcZV8W5I =oYjۍװtUgWS1-Od K2if׍$^ۏ;jBzj)YHjJ?[bOcq?xv^IO6RY51 44ր$aXHK vtp3vup739ZVkd7-Od`szdLb\2/-/je̞KW!^BB-=%j嵅MBzd=Th#JϞ5 @ x-$ YPz賨|0jȵxANf qɤ#5%$b[w AAF~,[%Y|C}Ǧ]6ORgrq$;a݂}{ aƐMH~lE,U'{,AB\ VUO#[yw͋Qc69$=7{bGd@eʀk䑎ot<8ZX-dي$z4gr2 ǓB! I9p|W@Z], eSvx[2$I ϝ,͙d4tiwP8OGŢ7-) c!ZFZG|ĨkeY H!,_B9_d);yH5^2Ƙ˦%{k_nwzlަx:<}HIO~t g@B7m|?hhUU4_}co0\;[+6rFO-hG ƔQQ*)h* ˽E+Ns?OԘzŝ9{}krVg.$q mQX).ESGU(!Sф;7׌߷3-2r;!`zAĿ>}5*q!6YYKq_eXUA1ޫ+F6m+{5e2z2"wbh|})b+*ʂ`9PTMs FhB]z?I)_̚ōT=sJ4}*d { Ϥ>cXٹv[%- YI3qы={ogW/a,ҥCݯzrUU!;s|ż)gFJdDnxs$v]4QƳony.>};A9s&;f͢QFk^ }0dX49s=; 6X~k}Sal߳o!X4<pmذa :AGlauyW#߂l2*7K;o/]|χ]ptTSkط"Oà8] e͒L(EV|SxmɃsN>́X`%%%^ P[[k:l2_>84M5s /ͯ4ٿ x>ΐYMݝ#~?Q \/D$xw]oް!8WfLw}w4'N@vyB~.`ٲelܵQCCUܒPH_@k@e}z=uzvWHZfyx^ ÄHsʬ ].|\I^$'>4ի4iR8?{ʇB2-5({G'th@>ĸ<ٺu+EEE^ ݇BհjN@7ĠA(//Vw2%oĈ :Dbbbx饗oO]-o>iheS0x$ƧP]w]"_uϟxʗy:$c,X,6,ƺblm36yP] &`M v%-Fg1l1kŔz;h.>~T7 {vdbdЅdXdf)OaG!ckGi'|U^#2QTEn>@UjَZ!|iG.dedYMSsLy4cs!ID4ˈgiy/bs'"!8plW{+_@l?e^^eee=x6.#Fgp`ժUL<;FVnu0xIHfYkY@_t}[g=.ʼn[q1cҏt`T8gϞ[gGv..%CQ]X-7ALSSSCRRhKs]8VS]t)!htVk`i}=ɕ-[~=ւ8Vr}sna¤KNzݴƿ@h~ܹsygYdI6L(C>xqp17AqqCqkbXxw?~<7),,$++{ J J3$юu@/ ~( NOOr [f:t{#Fp-#EC=$ ."󫀧[d{/#GdȑdddPZZJBBcƌ|JrLG*Nw#3=Z@ >3l6=SfIFgsL>λBΘH~uDnjÖ-sc$L?[g]J1žƀRp`o~ã>ʨQc״!!.Dg4p=_!o/,)Sf{KJJ8q۷oz-.ijU9p+hYPP@jj*+VzdGBCs!`ɪ.~Zu˷rl=+W棏tHyw4Ot:ȦJx4sZ%%͛Y)`iԢAII ׯ2Ͽ:% Ӂb2$$a;>GN~,޳KN<&q^UK;?qCwjUcSHl39v OJJ<'weÆ \yRLv]``ZZ "d] d>Yt’tٝdfcq~'+ N裭'Aη͹8/CI$dY?Obx-~hEY󨭭EU# MS9[}Hģ<E|rIMMnS__G%%;ᾇzFvIK\i[R7v?bF,̮ztUՍPTBiw#+./vQgs)lwp֭حH@tpfO}Md#'4[SUGMgr`[Td!KK<ۗO=(((`#Ȳޢ9вkڜL?X N6̆/D9)m}wzr;јЧ1.ܗFYbd^AI129:#Iwo8 ج1QÉ9qz?i **x"mȲ[q~Cm94@n^ t}h\W_$IVs]obڡŭ֛hS[[$Y|&%0,a)NW=$7? I-[\Ɋrۅ4?0>7XW<@ɀ;ʻq&T$I y2bFau(NWQS<1p@lVxlXm.+mGȲ }{m;6p)pYcX6خ]N?uܷ^X{v{$~}Bh9n<)xZn6G-l6o?f4Sݽw׼}BX-v&f*FL@ӣ$cJ l_d~z[M>ym8@ ;&sl Di Sgn@i*+yW %aIy,7|3Y(bۜ/XUi824{ Tם*[Y)CW(;ZI4YjϴܗiyZ:@?YgyFq;n%zRU{Xd2V\<.N$( ۉKqr5g?F2)70&WCvڏ80c l6iii|ٽU>)e`ArOӮb &tGi}4=SpB'`V(d`ޭ Z\UU}QOdJZJ&)zНؘDx=}nzT՜SBqnqx3fLձo_l,!ՅGҨo­p;,E{0&1pZ“gۍn4=P[>b]V1Flq¡N6zWmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???yq$??)D@J نH@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6!PNG  IHDRc IDATxwՕzr( irB `$kmvml5&" PB2B ьfI=S?nUuhbOHyj:ݪ{zιQ"3=œ _i S |=ohhC@ cm|U @Q@_O Wj .y< 1pBdg"L_6cA! (o8 ]B́ ԝD~5.y?o0)0d3BB3B7*?mzs/[GOA&@MF|^>>Ǿ1\qLa2pN cznܫ)Li6o@cs-'Wq1eBy&B&i"$yP 40MCF@  _f_GKqØx<01Ɉ.˴!a 1LI241̠$L _@Wq?j41au_0jgSQu 2BF  8Yqw1f==ol4M3GzζaWp{یN%.]q3\.y\ <.bK1%Ep"fq3\.y\ <.bK1%Ep"fq3\.y\ <.bK\_|8g䥯$S__OEE%%%۽m9 jߖ> ¨=uG_ U_:#F`ս`qu+}޷TUZs뭷) 9w*( ߀?]t;３%Kr6?䢋.bΝa{@Q$iPP4A^|[5\t~;˗/gŊ<󤤤P[[˾}8poW\q3gdq%I7y+qsw*FaPa1[6\t< b֭;vm۶YG?Q5&bݸn]s{,Y;HEAm9 7dǁuIz!}_h&B/P.1hÇI- @ƒXPl*R7?zk £>#<7mz1ׁOpӭn]0! L#(BA)kMJ5\$?0;,s+L1kVcu+@ȱav6ô$"dQU G̮lcW{k֬{ꫯ49u9rl߾STY=@ (MHU) L4C&XEA 0j{>p5\>̻O~vm߾d~s; !P-!mfEQQU E"g`0[%V7866n3.9{{ۘ՟q`Trf"8 `P9Fdٻ@p/fUbaQx/;YNׅ}Ϧʂ+oisː XM$umLMNooe\1VGWEU֝nǶs1: i `=pŽ:4]Of׮}ɓw[XNqV^ɞv3vS]SYsYʫR7 ~"O$Aqq!wRÀv…dggK a >$pI,'Hy6q"h5!%_V'~8SȮ ib̙6lO?vsXoZT)c97 Ov/Q\Iavʈ[=ƫ,!Bq~ˇc-ZĔ)Sz'D 547д䭷bqcժU?֭[6m| xhmAm픷Sz;gDD#LMcHE"򨪎?gi#(`&PcT <7p]>'`߾} וo-OE>`Ȯ#Rl\p),,?yy&jqGϚxfZl8\p<5D)fUm)MY^nVi)f:KO^ =M 1Oؽ3g:yyywϛwmrW:7Wa;M7ʕcԕ(PLPƎ(?>n/-;rꛫd9/7+c /03f҇4״"sm 7󫽧PIdt3#α%"_hFU5Lm5o l/qnodÆ ̱=:qҤI´DÃX@t&'O5ef'xR59R%Fkשn(xߧ=2{m{1رc]C{BaC⍝y2^𲦮"MUo]I_EaoY^tA=/ÁVłu1x`>#ƌ&`1ՑaZ7Qݤ$Q_:DٙPU &cFYM1IO6uS=T+@W k׮eJ9y HNNvah0pkd?CM]9>A&_ M^K4Å Y`69,~w(bQaJ{Ơkt8ȶmۺo!KpTFӭtT{OQY{R R2a*g}&\<#gƧyʩ)LmP> Kpg"zS!Ma&bE0 LN2< 2ʥ#WS[ʚ2@mw_'O䮻⦛n7@݇c?se 8t|W]vEcaIcwGBU5:ZA/]{'߄*h}JFD7iA$jd hWD {t&*-#rr޽iqCM 76"]]ThhWOS\4hBNd~϶>m=&<הB1m24Uuc Y1wܹ]*#/#(\~gGK""$OrxkP=E4gϢ>|=nQseiz`Yؼ>n8  [ZO AO0hhbH1ђz<JM}U2+1 'MtɂNZhs&ߌYz$yLE0íϗWWWגHNJk)Vi)ٓ,ٖ㪩Aq&]S]WNUm͵f31;&]"zBF̞rsLQٍjhNbEoo8k{g($}|f7o/*gZܦӥv|ժWU';>A}S !#ėW| x<ݔކ3l%-S]ۮ^өk]7.tUC)SXա'bg_qnf4'ڏn:5 m.r MFZ-]_ C-:B=riAM^`԰"Zy{McٿJx~ks`Vd呕Q@~4UW/}i \('}HN Sԣ%EˁaK!X9p뭷r2 ."/{IzJ "$>aY8Ǩ}X퉂&FvwFؙzNZ3x&Yiy gɞNwa.!l"<"Л]51APÛ3b[mL};-E!ٷV2_1B@ RUWSγn᱐.g){ ~~aq@[v#6DΛ)(yZ٫,DA [FI!wgVF$5}{}<+}$O @%I8ݒ@4&NA}  G:_XIM]%9q6＆IM{uF~sdY!j*+g7z۴ j|`h{̾BdhP$}uԟ=_E=2ȿE[vֿP;֟c.ٛ:`^ARBf+[oY.:^!oeKm$M5TוSQuGI.=]_b@p%2ٲu5uL]OBW=ֳajr2 ,]:^OᢋP0'k4̓j؀3 AVH\Gem)egst[?ܚqY)PtLUH&;=Nלӓ] 3D>hyξ~yCPFʣ#.z9RtPX['^,H$ A|F<.h;vHyꛪ 59DUsђufIuYtI-͠u[ ͵Um$ _$ Wo"9)'Yx+O%3׺le [Q>8( \aW<7\a;U{Oqߣ땭7cG =5G."=5]䟾Ӧ21G8bu]z{=b"^ :[aPQ9Rg$ KeOmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES12FJKa|$$|$TA  E֢QZEj CBZI/EQ!Zj/Z5T?QBZT5jC&E֢QZEj/ZC_PPk?֤?RkKQ_Zj/Z?_EPZT5֟R֤֢֗H H$$ I A?Pp fDDWDDGDDEWDUUDDDUTUUUUUUUDDDUUQQUQU_DDUU@DEUUUUUUUDDDUUQQUQW@Q@?UUP_UTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue 13p a 1063ac1P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1binding site for residue 13p b 1073ac2P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1binding site for residue 13p c 1083ac3P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1binding site for residue 13p d 1093ac4P*1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13Q94B1@6 ]6 WF C BjBjF j*5_jj֤֢ T'IUSEGZUOR?Z֢֡]u#Z _ _֩?֡__ZZZ֭j*5US֢֡]u#Z $$A@ $ H PZPZBZjZZ5iBIRUTQQ֭j*5USԏ֩5_]iH֭jFBjBjOj*5_jj֤֢֡j*?ZUT_]iH֭jFjG $ A$ @I A $/֡/֤kP֢Z֡֡jMj*?ZPEGRԟU?TZUT#Mjj*5Z_R5Z/PZPZjZjZZ5_Zj֢_U?jj*5Z_R5Z/Z@I A A$I @H H$ L,p f **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$ **DDDUU*DDDDJ""$UUUUT"""I$B!$I$I%UUU$DI$UUHUUUUUUI$UUUIUUUUIURI$DDDD""I%UUUUI"""$I$I$I%UUU$DI$UUHUUUUUUI$9!ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn a 301ac1V1ubinding site for residue zn a 302ac2Xo1ubinding site for residue zn a 303ac381ubinding site for residue zn a 304ac4r1}binding site for residue na a 310ac5 1binding site for residue 13p a 321ac6U1vbinding site for residue act a 287ac81met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1ubinding site for residue zn b 301bc2V1ubinding site for residue zn b 302bc3881ubinding site for residue zn b 286bc5nn1}binding site for residue na b 311bc6 1binding site for residue 13p b 321bc7U*1vbinding site for residue act b 287bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESii1met->mse selenomethionine MOD_RES1݃݃?333333?333333?333333???????@???0K; D@33fructose-bisphosphate aldolase, class ii; chain: a, b; synonym: fructose 1,6-bisphosphate aldolase; ec: 4.1.2.13; engineered: yes3Q943q94 P 31 2 1 BO\BO\C??@ ab??????zz?@IO; AAMMMMMHMHHMMMMMMHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW.aah         ppfffff fffff ffffff fff ffffffff ffffffffffffff fffffffffffffffff fffffff ffffffffffbb)         pffffff ffff ffffff fff ffffffff ffffffffffff fffffffffffffffff fffffff ffffffffffaazn'Caazn2'Caazn3'Caazn4'Caana'? ..]aa13p  from trX13p1,3-dihydroxyacetonephosphateaazn5'Ce ms_modaaact`Xact acetate ionaaact2`Xact acetate ionbbzn'Cbbzn2'C X bbzn3'C0bbzn4'Cc bbzn5'C H Fbbna' . +bb13p  4 X13p1,3-dihydroxyacetonephosphatebbact`X{ y Xact acetate ionbbact2`Xact acetate ionawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193 _mse  _pro     _leu  _val _ser  "$! #"% _mse %$&(,%'&%)(*)+*- Hlys &-,.05-/.-102132436 Hglu .6579>6876:9;:<=;;?  Hmse7?>@BF?A@?CBDCEDG  Hleu@GFHJNGIHGKJLMKKO  HasnHONPRVOQPOSRTUSSW  Hlys PWVXZ_WYXW[Z\[]\^]`  Hala X`_acd`ba`e Hleuaedfhlegfeihjkiim Hglu fmlnpumonmqprqstrrv Hglynvuwyvxwz _lys wzy{}z|{z~}~ _tyr { _ala  Eval Egly Egln  Ephe  Easn _mse _asn _asn Hleu Hglu  Htrp  Hthr  Hgln ! Hala " Hile        # Hleu$ Hala % Hala  !& Hala ! "$%!#"!&' Hglu "&%').&('&*)+*,-++/( Hglu '/.027/10/324356448) _glu 0879;@8:98<;=<>?==A* _lys 9A@BDIACBAEDFEGFHGJ+ _ser BJIKMOJLKJNMP, _proKPUOQSVPRQPTSUOTW- EvalQWVXZ]WYXW[\ZZ^. EileX^]_ae^`_^bcadabf/ Eleu_fegimfhgfjikljjn0 Eglygnmoqnpor1 Evalorqsuxrtsrvwuuy2 Eser syxz|~y{zy}|3 Hglu z~4 Hgly5 Hala 6 Hala 7 Harg 8 Hhis 9 _mse: _thr; _gly< Hphe = Hlys > Hthr? Hval@ HvalA Hala B HmseC HvalD Hlys E Hala  F Hleu           G Hile H Hglu ! "I Hglu "!#%*"$#"&%'&()''+J _mse#+*,.2+-,+/.0/103K _asn,3246:3543768977;L _ile4;:<>B;=<;?@>A>?CM _thr<CBDFICEDCGHFFJN _valDJIKMPJLKJNOMMQO _proKQVPRTWQSRQUTVPUXP EvalRXWY[^XZYX\][[_Q Eala Y_^`bc_a`_dR Eile`dcegkdfedhigjghlS Ehis elkmoulnmlpoqrpsptqtrsvT Eleumvuwy}vxwvzy{|zz~U Easpw~}~~V _his W BglyX _ser Y _ser Z Hphe [ Hglu \ Hlys ] Hcys ^ Hlys _ Hglu ` Hala a Hileb Haspc Hala d _glye _phe f _thrg Eser    h Eval       i Emse j Eile! "k _asp"!#%)"$#"&%'(&&*l _ala #*)+-.*,+*/m _ser +/.024/10/325n _his 05468>576598:;9<9=:=;<?o _his 6?>@BH?A@?CBDECFCGDGEFIp _pro@INHJLOIKJIMLNHMPq Hphe JPOQSZPRQPTSUVTWTXUYVYWX[r Hglu Q[Z\^c[]\[_^`_ab``ds Hglu \dcegldfedhgihjkiimt Hasnemlnptmonmqprsqquu Hvalnutvx{uwvuyzxx|v Hglu v|{}|~}|w Hthr}x Hthry Hlys z Hlys { Hval| Hval} Hglu ~ Htyr  Hala  Hhis  Gala  Garg  _asn _val Eser  Eval Eglu      Eala        Eglu   Eleu! " _gly"!#%"$#& Bthr#&%'),&('&*+))- _val'-,.03-/.-12004 Bgly.43574658 _gly5879;8:9< _gln 9<;=?D<>=<@?A@BCAAE _glu =EDFHMEGFEIHJIKLJJN _aspFNMOQUNPONRQSTRRV _aspOVUWY]VXWVZY[\ZZ^ _valW^]_ad^`_^bcaae Gile_edfhlegfeijhkhim Gala fmlnpqmonmr Gglu nrqsuzrtsrvuwvxyww{ Gglys{z|~{}| _val|~ Bile _tyr  _ala  _asp Hpro Hala  Hglu  Hcys  Hlys  Hhis  Hleu Hval Hglu  Hala  Hthr _gly _ile _asp        Ecys      Eleu Eala   Epro %!#& "! $#%$' _ala !'&(*+')(', _leu(,+-/3,.-,0/12004 _gly-43574658 _ser 5879;=8:98<;> Bval9>=?AD>@?>BCAAE _his ?EDFHNEGFEIHJKILIMJMKLO _glyFONPROQPS _proPSXRTVYSUTSWVXRWZ _tyr TZY[]eZ\[Z^]_`^a^b_c`cabdcf _lys [feginfhgfjikjlkmlo _glygonproqps _glu psrtv{sutswvxwyzxx| _prot|{}|~}|{ _asn} _leu _gly Hphe  Hala  Hglu  Hmse Hglu  Hgln  Hval Harg  Hasp Hphe  Hthr _gly _val _pro Bleu          Eval  Eleu _his  "(! #"$%#&#'$'%&) _gly )(*,)+*- _gly*-,.0-/.1 _thr.10247132156448 _gly2879;8:9< _ile9<;=?C<>=<@A?B?@D _pro=DICEGJDFEDHGICHK HthrEKJLNQKMLKOPNNR Hala LRQSUVRTSRW HaspSWVXZ^WYXW[Z\][[_ HileX_^`bf_a`_cdbebcg Hglu `gfhjogihgkjlkmnllp Hlys hpoqsxprqptsutvuwvy Hala qyxz|}y{zy~ Hilez~}~~ Hser  Gleu _gly Bthr _ser  Elys  Eile Easn Eval _asn Hthr Hglu  Hasn Hgln  Hile Hglu  Hphe    Hthr           Hlys   Hala  Hval "%! #$""& Harg  &%')0&('&*)+*,+-,./--1 Hglu '10249132154657866: Hval2:9;=@:<;:>?==A Hleu;A@BDHACBAEDFGEEI HasnBIHJLPIKJIMLNOMMQ Hlys JQPRTYQSRQUTVUWVXWZ _aspRZY[]aZ\[Z^]_`^^b _gln [bacejbdcbfegfhiggk _glu ckjlnskmlkonpoqrppt _valltsuwztvutxyww{ _tyr u{z|~{}|{~ _asp| Hpro Harg  Hlys  Hphe  Hile Hgly Hpro Hgly  Harg   Hasp  Hala   Hile  Hlys  Hala  Hthr Hval Hile          Hgly  Hlys  Hile $!" # !% Harg %$&(/%'&%)(*)+*,+-.,,0 Hglu &0/1380210435467559 Hphe 198:<C9;:9=<>?=@=A>B?B@AD _gly:DCEGDFEH _ser EHGIKMHJIHLKN _asnINMOQUNPONRQSTRRV _glyOVUWYVXWZ _lys WZY[]bZ\[Z^]_^`_a`c _ala [cbdfcegdcdi _mseihjlpikjimlnmonq _projqvprtwqsrqutvpux _leurxwy{xzyx|{}~|| _valy _ser  _mse Hlys  Hglu   Hmse  Hleu  Hasn  Hlys   Hala  Hleu Hglu  Hgly _lys  _tyr  _ala  Eval    Egly         Egln             Ephe                           Easn      "       !   # _mse  # " $ & * # % $ # ' & ( ' ) ( + _asn $ + * , . 2 + - , + / . 0 1 / / 3 _asn , 3 2 4 6 : 3 5 4 3 7 6 8 9 7 7 ; Hleu 4 ; : < > B ; = < ; ? > @ A ? ? C Hglu  < C B D F K C E D C G F H G I J H H L Htrp D L K M O Y L N M L P O Q R P S P T U Q T R S V R W T X U X V W Z Hthr M Z Y [ ] ` Z \ [ Z ^ _ ] ] a  Hgln  [ a ` b d i a c b a e d f e g h f f j! Hala b j i k m n j l k j o" Hile k o n p r v o q p o s t r u r s w# Hleu p w v x z ~ w y x w { z | } { { $ Hala x  ~   % Hala  & Hala  ' Hglu   ( Hglu   ) _glu   * _lys   + _ser  , _pro  - Eval  . Eile  / Eleu  0 Egly  1 Eval  2 _ser  3 Hglu   4 Hgly  5 Hala  6 Hala  7 Harg                8 Hhis            9 _mse                : _thr      !        "; _gly  " ! # % " $ # &< Hphe  # & % ' ) 0 & ( ' & * ) + , * - * . + / , / - . 1= Hlys  ' 1 0 2 4 9 1 3 2 1 5 4 6 5 7 6 8 7 :> Hthr 2 : 9 ; = @ : < ; : > ? = = A? Hval ; A @ B D G A C B A E F D D H@ Hval B H G I K N H J I H L M K K OA Hala I O N P R S O Q P O TB Hmse P T S U W [ T V U T X W Y X Z Y \C Hval U \ [ ] _ b \ ^ ] \ ` a _ _ cD Hlys  ] c b d f k c e d c g f h g i h j i lE Hala d l k m o p l n m l qF Hleu m q p r t x q s r q u t v w u u yG Hile r y x z | y { z y } ~ |  | } H Hglu  z  I Hglu   J _mse  K _asn  L _ile  M _thr  N _val  O _pro  P Eval  Q Eala  R Eile  S Ehis   T Eleu  U _asp  V _his   W Bgly  X _ser   Y _ser            Z Hphe                [ Hglu                   \ Hlys       $      ! " ! # " %] Hcys  % $ & ( * % ' & % ) ( +^ Hlys  & + * , . 3 + - , + / . 0 / 1 0 2 1 4_ Hglu  , 4 3 5 7 < 4 6 5 4 8 7 9 8 : ; 9 9 =` Hala 5 = < > @ A = ? > = Ba Hile > B A C E I B D C B F G E H E F Jb Hasp C J I K M Q J L K J N M O P N N Rc Hala K R Q S U V R T S R Wd _gly S W V X Z W Y X [e _phe  X [ Z \ ^ e [ ] \ [ _ ^ ` a _ b _ c ` d a d b c ff _thr \ f e g i l f h g f j k i i mg Eser g m l n p r m o n m q p sh Eval n s r t v y s u t s w x v v zi Emse t z y { } z | { z ~ }  ~  j Bile {  k _asp  l _ala  m _ser  n _his   o _his   p _pro  q Hphe   r Hglu   s Hglu   t Hasn  u Hval  v Hglu   w Hthr  x Hthr  y Hlys      z Hlys              { Hval           | Hval               } Hglu       #        ! "  $~ Htyr   $ # % ' / $ & % $ ( ' ) * ( + ( , ) - * - + , . - 0 Hala % 0 / 1 3 4 0 2 1 0 5 Hhis  1 5 4 6 8 > 5 7 6 5 9 8 : ; 9 < 9 = : = ; < ? Gala 6 ? > @ B C ? A @ ? 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ApA33AHAAEARAzA33AQAAffAHA AARAHAծAAAHA\)AAA AAAzA =AzA =A\Aw =AzA{A33AAA\A =AB \)B =BZBfBV(BN(A =A AAA+APAA33A33A =A AAzA =AAAAQAQA =AffAffAAA AzA{ =A33AApAzA A33AĸRAAA33AAHARAzARApA{AB{BHAffAAAABpB\B.\B<A{BOAB= =BBfzAA =AhQAAAffA{AzA͙B=qBBB\)BBBBBBBs=qB}\)ABffAB* ApA\)AzA =AHB\)ARA AA =AхBBwBkBxGB|\BspB|{BgpB.(B)B1GAffA\)B"RA뙚AB B7A=qBB{B%GABXzAGB A33AzAzHB A=qB>B{B;AAAABHB(B+BAmB=A\)A33B =AffB HB/BY(B33B#B \B+GB%B6HB6BB"B BffA33A=qBB0BpBRB0B)ABffBB=qABB&RA33 F1F2F3F4F5F6F7                  CCCC         C        CCCCC                 p p f f f             f f      f f                f f f              f                 f f f f f         f             f f     f f f f f                   f f f       f f f f f f f f f       f f f              f f     f f f f f f f f f f f f f f f              f f    f f f f f f            f                          f f f f f                         f f f f f p f f f f             f f      f f                 f f              f                 f f f f f         f             f f     f f f f f                   f f f       f f f f f f f f f f              f f     f f f f f f f f f f f f f f f              f f    f f f f f f            f                          f f f f f                         f f f f f "binding site for residue zn a 301Vac1 F"binding site for residue zn a 302Xoac2F"binding site for residue zn a 3038ac3F"binding site for residue zn a 304rac4F"binding site for residue na a 310ac50F"binding site for residue na a 310ac5F#binding site for residue 13p a 321Uac60FV#binding site for residue 13p a 321ac60F#binding site for residue 13p a 321ac60F#binding site for residue 13p a 321ac6F#binding site for residue act a 287ac8 F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine 99MOD_RESp=met->mse selenomethionine BBMOD_RESp=met->mse selenomethionine JJMOD_RESp=met->mse selenomethionine iiMOD_RESp=met->mse selenomethionine MOD_RESp"binding site for residue zn b 301Vbc2 F"binding site for residue zn b 30288bc3F"binding site for residue zn b 286nnbc5F"binding site for residue na b 311bc60F"binding site for residue na b 311bc6F#binding site for residue 13p b 321Ubc70F#binding site for residue 13p b 321bc7 F#binding site for residue 13p b 321bc7F#binding site for residue act b 287)bc8F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine 99MOD_RESp=met->mse selenomethionine BBMOD_RESp=met->mse selenomethionine JJMOD_RESp=met->mse selenomethionine iiMOD_RESp=met->mse selenomethionine MOD_RESp