/3.6-1h/data/swissprot/ 3KB8.pdbdupa 3H83.pdb( [html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]2.09 Angstrom Resolution Structure Of A Hypoxanthine-Guanine Phosphoribosyltransferase (Hpt-1) From Bacillus Anthracis Str. 'Ames Ancestor' In Complex With Gmp[/h3] [p]A.S.Halavaty, G.Minasov, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3KB8" target="blank"]3KB8[/a] [small](deposited on 20-OCT-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3H83.pdb3KB8 a_3KB8B1  3H833csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iￌ JzyBJG?WO ,U7,w`ٲ??c#<;??c#<;}g|ΟQH>%\gi OxxJsd\8s2l`-KI]wg_c ȲtTUSUYA#!*)/-&L"ﱂL#px5Y ^H ms?:IKxy|s FzY,- 6NP&d( c _O ?}{Rug-~v4Օ4V;ޜcxWd;Җ1nGgxw cWﺯox'wױῃ'WFCq]7X;z-~Hxw}<ܛ~piK_BUe{6jm>NL}7w?5qCZo쌗jD^v&Y)-)Ġ5n3GUg?1m=")c(+.d o6A gIOuXB"$ہ~[Z}C>W2J(נ˻~y a -x 'SԈ`<\T?M4LC8ш=GS@ 4od24O}RhV5Z3幹w~# <}[Kyx!M>H4p+}J=oԴ)^ [#)So^HBNo=qcs + )vM}rsVb|S UJd~8aUBj DxLONqL N| ?_no3܈7q! 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residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FFW | Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$( X8"@ |ᔌ]*3E ` o8: (ufb ֌ԡ(Vi4z (@@u.[DuEzTU҅vjJ$ڍn;g#vcxH\D&!HQu,py` <|<0iέ"SLѥ"B&(ii!5llm>\l]D Uoz^u\8* l[VUdߎp:N֏v(mD˄rH [Jd<.4r&iUc;v˨w<@p50X efDFaA&Jvvm(%&Yk 80>w;X"rpxl]b(+2}b8|@H@X, 6I 4]zNEiIPD XѕIsk.BgϞ2m͗ v%Y3܂UDYf7y0$   xIϸ%5;%IfVx_.Z CiGYV%O>0 $닏 CCևaһUxSN ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site 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4̖e`ONvț^A!\=i91jU7wm>4е:zwS2*1DK(j/:\>3(.X uVi.g*GhF}54FLMogmd+E>մ z%lW/QR~6/ D&DOqH PtA1Hw$\`Q'+UR*T:0kP;8nPl>y2+֡vc{/n{E?y6@m{17̹Ԏ$,K Ja9ջʇJg,Z+މIi,Mdw\.+K=d`tuy|hS-Piޟvlv;]5/{J tVs,ɓ"@RpL}y JGoKr=;x m9YOh Dn|i܍.@b C">~r`\{ժx&|4,s,IkYp\9< aT0BF+CAsb/A^wK?yǭ#?i2ְzL &!fPgԝ"Rի|[>$w+ω;NbjI)8v "y~N3fcCYߓH @+& P ugH}R[sv/aGU 1MGK.@!&v,pDnrd A^8JC5Wͱ'aU^nBOiB7z8$\_ \dPti&G(kIw AF"d$JbX"..fPj\q7]y~Y.ie(1}G$ $İF2<)bLZoY2~>ZѾ3)-/rвnKUp)l;0RbsUE3sL7-Pa*҅Z*GgEUPx@.|BneXEk7Y(#+BWϓt UlTF;L7xru|PAzy>\XB$|C^h e*9"Q=0r.BgCk%r@2uiw#juL3Q}! )lamX`oK`9!TƒiOPpë" 0 憵GT8.d@w%[6m N}kD$2@97!<5e)8x Ȅ]rFR2qxtF"7`2eFpÇ05 ;z\/_,_n#oQtnoEߜٽ85Mo a(ҀR0d.Hr"Zwyo;"/J\6S|?& gQo/2|%tZi~&*sqC"%ϬɊ?SeBefҙ0u5|-ۚfpfoZNP ̇kƺٞɪX#puuEq{A߲'kw 4i E~rUb|"A(E*PsQL}kMuO] O?̙ZBɟkA4 eViS6xvFQpe$졷=ɻWO%}0D(4nGXҟV&2ZMClu.rkA&bx6 WAPr Wþ.~zBv[T16S47w~l#t~x1yVrյ5te03K"9c"G4HHcb-)ͻ^#d\8ŬaE Nt80å)Y-/H"n_@ț] [&vwbM\2"F8s#KWƖ Tbh z_A9+uQ'}c2Hu;w(Z߼PFoۈ>]߬ޏ!J)QPG\#c9#c~M]ɱ]Qt )F-cުvlr O6D1RmGMSSSƤ$էrm8䳅nPE15&+"OіXqSoaB?Z3)VWG#&H$c.+N^~9n,K?ϵr|LjF(jcأs Q.5 jDy~(XN$vzXe?/_Vf95qzbD g(,9qF_ ߷nSSspV/\u ?Ô-bk~v"ڡ PM R ~:_E7mY6PG\PFi~|E+qK^"OG-Wm((Au8Pt@QEezk}1@M}3(&˖ڝ>MIQc@Jao/ υa r@CRʚ|EIe$$@X"Y  WTA⦒5bU Za}IVy#zY&z(')֙Htkn@bRk@ہR6McR <F*CH+kM)ʫR}br`PO el:IDATKQ-pO']O6k, K"I䪫 ;1l˫"HSfDbj暠+.zY®00~v8([kqQY8QOnsvj9JQu}7+˛)waЪNggszRK~:|b9R0E_ LzL^$ҕBT4b CE? `fz<_+aP,ā8 Bn~nyIY:=Z=͡bIlVDvna- D3UBF爃ӨAef0Nj!'I_}8Ti/L;y@,KwYZANq(8y'i$g!9'BPI$c)ES FoD >Fb /UDb7BQ A f촱v< [&it b"mG.|,@t r/y|iH]HpB?./ۻb0+(0wOU5@".&9 ʑcAAYb KxE1^V@1]IVE.-qc%f nxpW"E|a6P|]جiؔBY ['ձa-Go\zVqJy>:GU*bl4ncx6 ƍi*gM͞#Nz@TLOF&[@)jHҒPdmi佀XM ADE'\Y?JUvyhn v@Ώ9lzSÆJ1] ` b v^\oۊB jHM%37,rɔtcQZ3V_”MJ,}-%o*NeR|y~9}Nt"OjR,~ԕpIGΕc2e^ߝ8AEg!L ݚrG9PCZŎR ]e˲-3}-[C۩v*NUl<8a[cY&ݍNsOUfCj<#ƵvgJ `C [CqM y|xh>t(N/fx{cNU$(FHhj'EDUQu,BrwG*t q"qI~G[d#sDaG]1s4M`Rsm $DSbΖ=WRaz~{}CR/ୢr,&,N0,v+!ZY(:_ ieX! 3 oȟM$k4)mA!i0%Υ 图s,#o=mn)ޤѷ3WQrP\Ԙ {H!B<.P? 1b*Jyt8٣ DklE;~Os T3H)6 Ʀ]4nAB_m~ 쀟:o0]Yl=$F.Cvny ҘHǂ??Eb{>7su[K$==8߅cK0yLby< lFR [3Hi1Dɓ@< 7I j$ȓ@H' OQ#AF< Dy $5I j?.`g IENDB`move=1000;blend=1000;3H83F c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8<%FFT   || aBe 7(B"VXE(F~+N0JQiۭXʒ8TD x( ( r'"(i$H*4UkZ֚Eֵkji($HESc"1r! t!lZ6-cbL#Ű-H;3JPYcws5eUfUPx2N2BLP 2"ATC"2@\2"cP8P2DlșrkH( @;= pD{ߺz$xD.l  UUAUUDDP wM~ ~y8fO f8bZ֑amlSca(o$^s|zZ`cEņj &2& ۄBu9+~HaT ^UVn9Y3^bNrs9PALDPʯЪ mslv|!|g/{kwtss{c[UUW<2ES*S(=*eWsx\/!Q`k9s]]??Ri;?YB_ݙmpѐ<("  vW?2m{hhCBXT ,TЀhhذ$0xTL @*2" i&L†LAUf6 dHdf xAUAU__AUUAfk S3e "T ,z2@TUUUT N>7{~BRW?\l[Ҭsmh/e.݄c#Zȵ$agʪds \ p4Y߯n-#Z޼F+WDzuU"*@P74u^ֳ7ǽJz;m0q`X[Eb*$$Ţ2LJ@ `*"  0`r $4kbm-Hd`čIq1+JVeF-jMl`É)JE,ZFҷ)ZQL [zLMX[FĀh2cA8YĊZiBɦ & p ƶ1jGZHxwmo~n[diJ̕ձ2jh% $Pr 0X1EI0Z忟iffg|߻֌X [ *][mֵܯ:Ϡmmmiǿ;s?JLV, -m3߹hئ(ݻbAc#Ie|kΟٻ)wHC@klVb,j(]%)(CaA kZ.9_7~zzKG?+0 &:VoДb0ZY<3/zf޵7_3B1 $8tbŸc 6+%KVHHD$ lnЄ | J iA^[{>uu: l[3Ի;:fwuXo"QYݹXT+ofg۫m턗(lֶ+4iibhiB4&HqȤ6Pbƃ  Y"0Lh(r&(PDĉIkZta-ۥ m6*ƂQQQ1$`&P Pe*`rD&\H*HQ8`b@p %u.le5Iٝ,ϵ&$MiF(L9|J  m-߶߿lusmiZV{kn(B0#0bIB&H!FQc#Ų8@ \yQlQ,B[oArv6ZRX[ED\bbb`qv[Ujխnww_w~Lٙծ?3[}lŊZVXrm߲`čm7,ߴ!KMBзZmvg} l)[e I3s/}Q(@2D bF &Ps XR$TG54s!ms]9޵Ͻ/Lݟlmߙifwey?Pw?9ݲdCw컳wn?ߟ( 41ь Ԋ7v[ ؐp@4nЄ#ҕ+'mi#km֌(%y N-vgxf}k욑ſH_ u푧by|wuߝgnwOh$B0ecZkb-%ָH4Q"j&qiA$QM4M(i\1le+BRkJkK+@LM.$$&*`,p. P 0`ɓ$\2eJ*T1A!D6&&BI_Zk~b4Zҝhwo[ֵɅꈃB@Om[.ܖvJ[cbiqM4\N4sR4QEG Ãƃ (Q@Š(aEP0(y<"yOO<<QE<<QE\0(QE (QE=C=C'O=@瞢.QE (QE<<0 URŘeeE}CdA&OuY,J8 \l>)RmN:n.N2qQ%tXx@4XAQuimg_m2f@  ' :s tHɓbKN: e]}dX}xJtmfUY8X4\XqGa}TY7M@N8|QE0$쾓kp@ؙ", qU0/Uu[ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@??+3H83AfffL?p}-+3KB8Afff333?p}0?ss$??+_G p$F@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1YCPNG  IHDRc IDATxwT;egXWQ+أ!k5bLbĂ,;lﻳ=?nپ $??pgn=399y EL>mZ)aphʻMzLA4EJIicNhyA қiUBVzV):x [^U5͍(Bmľ#[9L0 |l8r?hj˿D PK8ZƦznGǵ-K_UUTTEE6G;*ʫsWW*٫`6E%+Yws'Ы&Dpoަd GE?8G'3Phm:j1~tF/M#GY?uN@6*k GC\yz47)4|4|t|ҶOǎ˝^s x>"zýq.J(~HgQ$d"޳-Zh!BG(^gOBЃ:H)i SQ} n@:0 ./3$=5g)%AJOs~C[zwqR躎nDQ C7*P4>?MsQYY/[-Y0&TR*jPv{Sh|7Ro1 HISI4_$4TE(D XGu})hpPH4@^Muu}}d᫋% үvtPE}cQ=žC;kdaGvz>}Ipe:P3lx@P]_BYA^_c̘iqΪU_c_sGwo\U՜Npt=.ur3.B L}.nwQ$P$?%VAW-ilFj*k(9Vm$Pp|aD古oxO?/ѭ1sƥ+a ({Œӟ,&\*;^Ｓ%K^O*ɠQFh4L$$=̴>TSQsEQX46@ sy#͟ES`rJ*]jL┱8; &?>Y(ҷ~եk$lyfMM0;kKط|=7l-G\t1 N HBp6,O>{Ҽn}cilSskHO0Hu])U%TcˮUj'7y\q@3 *7~oݺ~ONG ζW_0;71&Q(uϛF5 a:5GX864MmC%ťTWќ/cH`j)ݫ_bx}wiTw>=.?@?aӴQʭz8N@ hHH4LCS5PsLvF>qlyx~Fk^x~? k$(Uٱi;V94_}ot4q4zW{iL}.>O:BQ`?x晏=޸3p$h~A$ CU?ZzZrl7':l\@`=e9J(ԮOFJB"S2hlgykan~.:M(B]Cy3cjSF#[ELTוj ϚMv_F[wN<7EQ%){8*T};UQ/KؾL!cMHkh?2N'͗ͩcXR[S֝xt) k%FH4EQ.t<ןP(>,M pKOds i-*֊y(hq@0aDF|C GICZ8gģC3*b^[D㊀GW׬~!Pw|Fybͮݲt2qAQTE=L6mMac%~`}5kUۀӻkĐF/iT[〖?h_>z/% SY{MwSzP,c[.--ŋ> 4sOs^EE!|YjqL[#ű4BAQ egKNPUW°#9};#{=syZ4cUQ+?W{`0KyӮbXgCr#%Y|ˋn?XJ<sܻH0HYFܾ0CFy ~6o>Olj^5 RB@qQ4Zr-EGW]y}ShEQy@p|7CCs{P4B(h_F pinvGd@BDG91ҦC~JAwd=`ƗϪ f߳B0|Հh5 &F4T Ez= tw;WK#A. m<4)%PL{@ޗyko|z& ONxjHjǨQEqx=3(E6AJnWH)c]RpΌ(BFz}G?~i^WON .S2#K3QJ!f̣,][n+&_/;*lsK7m[ L(*: Cl?`סEAJjwR᧯m{?DJ??E+yeNyyۓdy<.Wcd'AEFH]RG#'l+<=!?e0w8|r;]RRҳJ1dZ,,a(Gvv9jQ#hG92tޝ2 (>{_|uߙ\ N>8lq¤nC?ϲe[xYd6k*& IfqbOHI0Ȩv Es 2FͻL /~OcQh=дy߭`G#?n/v7XqpcoZNF?k](^^?iw5qL&5n MҘҪɲ2$HL'[b[0ƍ2[Jho  1PzF+? 886naghr~(\l ˖mgK0|M o }&7,H>iyɜ Oar2Xc>I9zEcw;y҈FTח=УFH [@񫻈6ivGֲ("4j~a G}ݾVw9Ձ؞CM\s4f_0nͬX{L5ɔeٜXE:|şÁ" 3 4(≯fjBAߑogME|lڄK`q!MsH(@pjj*;m_Ϸ=ZԩѴ=o`Mz^w%G?o8G[FPUhۭƛKR֓`mD' wi:aP\'FV̙zRƈ{X^pHi ҃@ 6ኊPT 3Biu~@b [omӸk$+,o Hvz_t#eg[x؉Mm(3KNTaDY: )̻uEo "СH crfJ? !fr9R)(lHf3PB4#FAIsNGQ =bghqlq3Oگ,\֡>*kO,g;lx℉ ǝ#l2}[-3t@2uHǕWC%;|&am$.DQ5>_("T4غCK0(B0m:`xԕ|Si} ); wa<O>W5MH>y|tlhBز#6$RB Tϰ{ӄ9_| Vו:dDף6SX0"\o* Ι~)YqF =C)emF (ڛ& Dhm]s30OAD2x.,~Lq)GD<"$IQcNib90bڔow=Jib"3&^Đ kd}R٬܁YhFB8E>30V=묑U+l{y'۶FV&iWwܞ9Q+;Y=j^0݇6'q1{c+A(̰UC:RJ[G[nH)@un̄p<9s1LDy Fy卜tR{7?wwNZf­-=߅{iW#PX1J*'{01F[Je G+iq\kh~xH$IQ0ws8ds1po/{b@>xjny!:/ûۓ^-h"uKJ3wꕌ2A#)iʥ9u>yfv^VdH$Mca\|<ר+vHЁcSkƈ'ۭQ@ii=W_= FS_mx?lxUYlAA5dfV s^ETTؾm'^HJv\?/=Xw>z0i8>Y?i TmUc!z`5}KAp㊢b? #Fa,Xjih\4oClxn:-^#m˗V=q$֘Eqћeژ=:\g@A0tc$a55<%y6n7ٳ3fLݻy?f6nL5"W-H\;,<-_QjwwviF[KWѡ0xY\[Jb͖WsyŴNY^eϸH4lϰӁ߬`UM}gQTԺMٔomc*^ǿ@s8> RpfO/QgN/Y$M$" Qj-aΔ? 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,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8{FFY UUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!TTZT֪jOjMiZjU֩5ZZԟZB֪խ?!UZC_I5U/B?_֫ZkԚ_UZT(CH$ $I H$B!!DDDI$I I H$ $"D"DDDIIA$I$I$I$IA$I$I$I'W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???``$??8ffڿbD@?P2?P2?P2??@@@x@x@ ???333333?333333???#~j????333333? 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P'lcِmABW[>@a9d g&S]Bd{˛ogN 1l1AUW9EMNV6ml5^$g9U5(՛galr^ZX+l YlB8>iFIbZhw}7}]>twЬq`9_~?#~tn{6בc{[}܅lkl&WvOFdo̺rC7\7+2rx=B\./OGrRsΛw)6k,KBkmQnep„ k5NpC?ϒ%K;Xv-+8,$ύ >e=u/~tw'3~ "^jԹQTY'ld葊RN7sy裏74?ȂFϿA9I^?΢au}b$>&򪣬6^:  ؼ^ǔ)YXO ZG kDA/TNo.>EZ};4P5?֠I4tRL%mԑuVRhѶ낽gϞL((` 9QC'sh z`̼v왷Qdg9１[†L Æe2sf?z pӰJ_"k/urĀu*_7 ߺ'TTU9xBtDbh!qcޫCadyե#XE!NO #M?]w]#OFl\UfA F"*6,@MmKW>dX0jƍjvb˙Vյe 7iWUcR Q f܂*׆`̨e>[oA?6,zf bQUsg9ux${ [N^ԑkxЛQF?9s&_~%^x!\pfG 5t80~lcpYs42f0bDwO3D_'w#;~,})PѮFPk"m_c/^Ct[&]Ʃr̟?H^x!Xʸu%WfxFa8M`|Ahy䩧qU5g3|]QkY.c`\}hżB}XSG8⢒ۖ4>CfJ|٨sj?0@3(EH<[_n`vf\rɫ E2 "|q٬Z\{j>zHtԩSڟyͅq`jgFk% 5!˟3i;bj-r_|K.ACLt SȈ#.+N3jy=/v;n79 c0eFEYY%%%rJƍɃ.V}s\ǢtN@lT?ᥦiMV4T]kPa \$Hy|Xn>op[;2… pWoSs1^0NjبåT'I`|du |t`6QZ̡ZxXSKI֒4 %xGi16_=si:?tCছ{뭷8sw*E;IN Ahl0Cx杦?wtD"6k_^)j<8gEJ_:Z׵lׯT?xpY(1 L38˗/חp΃xϰzhu~;y3¢D,&G8r%Y>kD8bPUQP[sΕ> Y$clhB}2_3w\V+.cʔ),_ I8" ZH~h&-7tNll1,VD#7*q9$$KQl;EeA ΅S'r2[):ʾClPY]a"<,x ކtE!hQ3H1ByddKxX4hŻ~]i>{vcrB'd l+NrGSbc$)a@L ~-QD8bړ/c/1YuV""~G$ITUUx  }Ѭh$L-ml #xe/fʚ_ײݻwI P'4 N(| /+⹨x4E! d&jjTG@Pk=Ɨ7d|ʹc\suYl[D&UUEٕϐi{ 3G_La.Zc-^SWI0>_fї_̳j*Ə<& ֠Ojsxg&;{&G&%24'f_0E&ф]ʇ.Y83883B^o-ʱBdh͗g3~ U5WM7Rߖ%@"PDB7YY4mGΝSR2ґ/h[̚Ťg!&d_ xwԨQ,Y΅^t촁~g;EU <кR s_ hd䯚< wPBX+`11EGl#STTXwpEj*Y<.zE=díWr3<>؀ |HOw .ЪrM3n *7ge1Lyv6 b&pm$eG!-9T)f֘T8 rFuqIQ5՟[KO)y<<, Y-f=Fp#*3 v*8?>5xqdWymzDh&$g! 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PO+'3FNWr]i[*Ժ*q{ju-}Jd2SZQzE3 pݞ=8O9CY#+FVu1Tuz+t~FQ9oy:zG4Mc\Y>kx,+Jjز @Q=oy:v JFu׌#hԧL$gPlx*v$v[ @_0:Ao=#輹<'w-').ljL4 l-7n~S_ dUci_: ʠ* u$P.ɤhs +sBP!iHOC1x$'r;!id͊tʹӁڟQ:+8Xưm)8}bos0aQ_㣃ED&$:"ܹ½zAE$hE_>[P5bhtAϓ*08rdEǃ.tSr1dⲃ$Ʀ,{u_l~٣ c(…R/ ++^Z^'mU<Y*{Թk+C/j n'*G6zj8_MCꉣi*חWm4Fm14gtcܞ:\U89T[/p+X:4UE1ݫ 'j:׷xEDzrl8¢Q=.}"Oڍ. sڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t"Oڍ.t-gaIENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FFn UUUUUUUUUUUUUUUUWUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW8*/|||| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj I $*UBT*THTJTCJ*U$*UU B_ PRBUSB?T5ZC֪jZZkuZ_jjVP5Z֨P$I$IA$$HB"B!I"""$@I H$ $"D"DDDI $I H$I$I$ $I H$I$I$WWW Wf#B?y'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???H'H$???1@ &@L@?s?s?s??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11PNG  IHDRcRIDATxyp՝?HiÒ-۲a0I906$2q`Y*"]HlX.8B8B \mlmu˺f4{354ҌFcܞ;_$R^2K.EW`VL5&P2mX@ȇ}Ng 0W,L5&03Z;j~:&e IcttՈ*W^L1 cMtZz/aO&MtZhjF*W]L4Mp5ՄDegڤQm5#6d'xn:Mtt5X}!lٌW]p 񤈖nڻnE*W2ēBۏ riS2ēbێ=jm Cx|n:]͸}Nj6ē&t5ur٩% C~g{%kR˸ ='$ymDPrZ-a5q8.w; bh0ZewS( 7`ȒA7AX j~T5P8HX z =,eugqg`$~|KA (hFUñǰ"sT=fxr~Ι7b}*AJTMEthZ).Me{<~7noOm;H'R:^<=<@Ћ߭@!/+G=m9%ZDO[Y(6=>'VK22p̩\@mӾT>} !P@(j#1j˱c%ǒb3'REYq%;yE3d27>{aTE!Dq9_aߨ(R-O\zȵ˝5s38([XMJެEy#VJ$VKJHM WO;9vc1} mSm;iAFBb=j^D‹(QjHu-R9 =8s#*9 BG[~u,F'L<)8 &"v>iRƔ9ƭzặVjڻj!lik4)-!] 4h^z]x(Y>u` BVEo\玲tSVT 7V<šET؇֎Za5DQAYZ exr#|qMvz@-ɐ˗ޖzIQa9HФDfqxװX,Y&e(Ğ79'E@(hR#fopq**xyW/RTz/k<ƔבV>$NWS2͡ Jy jkky衇RPzA`#$-uȠ fxnZ'GPԲ* p`ҥK ü#3xꚿ%ZCm7[2-$3B#ѡ%#ޛ0?$YҙXsBjDJ'|B#H~p[zJQd /nTv9&Y^hR ~|T z3F zo[̨Kg`z￟5:IU⩿e176^u JK3seL-"ǒA/@t_GMً=Hwmd8O}}&Shb&/J!0i$ZZZNZ݆FytAO]D dݻQM6e1B9˳_bҤBTUPHo:u*˗SS8{բOy|.|M twwsoGج̭NgjyiÒaӦ ٲ}|a ~Xj~rrrZuF{G1t>#>7~ޙG><J<z+;w+8gڵАxD )HVtɒ%|>I._XМyD\Sن{exKii)vR\ΝGQAaJJJx뭡{|#!vɹ}ǯ~~ g'2/iU &`mߵϽK@_':& UUUL&Xfw2]4MVD*wpc_ %p=e˖AmYCP3=CUU?-/|oEo_M"a6i*ec1[DJxcc I[W}VA<ƍy':ݻh 7?E "v$O&5I=6e^LL}И3mf^XyYw:YzEu76~x:s߼x&!|xn׿{ϧޅow#cT?B%/:DF!#x}ka£{Yp}EАnÞ5 y46:)*1}"^|E*\YCII Ou#^(}qX TTT-Ծ}vy ~ 8G("W1qv :'cC k>Ph/[DQA9%*ȱb1۲Y ?f>֭cj ё_93z~:W'dv;Dmˣ(^JWc;z커HpX,:7ї#Ic( ]0^_'Ŏ &egs |<;(u~1?ofXe_m˛S$2DBA/ ,&+ԘPPF}|Φ~L 譎}.s3#ǚGIєkyR2ֵמV ۱cBz619 Q'W_4dXsԥE9Ҩg.,vJ\PQJ8fm/|$>Xj[MjB;?M̜Y@k?}]72oaqNEQAyd4Ms SF<[\OngNc\sMLo-_ŋtb1  _OWe_NѣٳN" Bjr n޼?0;&#%Ztz)#>; <1ZWWGuu56 5me&'Dv~>&K=o[eeܰaɏ  a͛7gsN"'&'̐%dͼ*++p{Ȗl]^?ɶJ9t,+!Uꩤ^z%͟AWƽ~a.z-VNܷJәP\8 (TC :^z%>n՚"#?>psD!ϲnݺXeLHd\(+0sf$lk^Pছnm۶k.v￟؉'$(q{:e˖q$ʔE} 9sdJ=Ŋ+Xjf|v;v}2аGa\B7xIx޾}{KQ Mjtu<6xÇٺuIϹ iRuDb*fr۸qcח\rɠ1`H\,-*+&Ζg qZ6mB$ 83cƌ>d~NFugުvm|Q_W#Ȉ|n2.3k,EB^70JT1{lJKK9s8x ۶m˴IJ;fsp֎ڤ}Cq!Xpau4METH,H?[N5\[&L]˷I?.<:^7a5RcrPӂhR%Ѥb|+C<㓼4c@X VH4yx R#i-:D ĖF C<zHgc>x ҥF3T  G|ʋz!T#Ц+ \ZdgVx jz*ݡ1ciR$eŕ'=A$2McǠz̺q2^;"{ C.8*<A?\L= #~ub "-ݽ}.C<ݱ># $DHÀfC< 4;͆x "y a !*ȁ̆x  T}Z Sc`@t01Mjhu  &cgoनjX,l{2cpRnB !5&5*'g1ܜ,f+6k>V (z"L  <[&B57؉!!X  \!#)ŊIENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF[ UUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU?UEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZ*U'jjZZZkVZCMj֯V'֨PRT*SRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$W WfWW#UIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???HH$??IK2@B@?u?u?u??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12PNG  IHDRcIDATx{G}?=3;;I'l!UQ Eˉ!q"pI"<$@H cL8D O=,?$Yuޯݝ=3;{ήw>Us;;ݿ$ftuEh:Є XM7HO.n݋Z3t+Q:B&3Q Oˏ/LR(Lb[y H9L0Nޚ$W 'a&?(usS]tTQ̫լKizQʏmU EUP½tE %<^1(iE+P'L IۄbEu翝>\Q:1b@”,vuGձ- 8 >tI k/qC?W{kSE|4\^>4箾ww&4ZRzZޱֿBrK W<3 g*n,Yj.teMTËu@qлgf$ikYv[II),E.xKkɔ%5G-f"E L={^*1k?:׿3\'ʼ1,=lx͕ZfWI\&OL?7u8Pr_z"ͮ]u wwKY*L(b^$)}^ܽqJ)BT qVO<P7R t3+֥ 4:Tvٵ_Lme "g6۽^p:?G?w|7c Զ`o] nFhM/wl[Kx՞M@T,S1T@+]@^yY f#z&Jm[*W@5a0/#/2S*0{}z3mp*KDo9?U-̄iojFd"_{4Մt\(<B3!l{˵?TF93/ 3fZ%ߌ9ߛ-S?(ffP8qdnåʗnTvdW?{p, ˱-;|I! .YUg n;"QkK6A UV%DkYŽP nzѐ8ؖM; R3%XRp0|Åh#W_HV{䨒~ mT} !un3i FXض3%.J"n_z;Ife8Sǟե8^~&U rXg̱[ް"+J [ ' \ÿ O#P3 *ި]#Ԛt_O'a9Ldۻ'&>'¼pF)i^bM)W?6ضe[Xepmzǟ!4gQ o@L°ԚvGB8Z֯_OOOD;n$93ti\}b0uC 34<0 -<k6 ƻ>tc_< X,8ۖ/&G:cPO4LË!A/$YEww76l o|Ƕmnӛǹo`W;`ddÇw0!㏼xڱCXvA񼏥j_/]SsFtuua>X;a;6L]8ScAw$ׇ>̬l(_r"hئ44M)4)*Д㌍mFt3(mƼ* l ٖ4ꪫ0M뮻.lSPna]٢Rܷ>-6c^ sh1lC M_l AӲ=Sif 30'nׄiCᎢDqFc yCI) | l@=AR<ҙsCwo;BϦ?&:Vöd /&F>Mi.`y)ް6t irQ rpas5f!0o*#FH͗b}Y@ZB@]3@OFX9o[H4MպW(XдtSX2@$p8`•LfcZC[4A(` hIt(GyDH[5蚡8c徾AL>7 Ĵ9'a=\JyI w94ެypƋ5{VRdԺyEB_sjbxzfFsppFsG$ ˆ<5'>L$TLeY=M9&GJ'Dz]c"#mʹ=ϟvP %x/DDCUa3?9xျ%<1fs9wGeعNj\Jei=:lxk|fRNW8Ս)5' F()`/C"ttnw 1 h]JQͱ[LI3FgO I+NqbL)5%Hqf˱|t:H$ 3F,ǩ+H& <``0H("z{a"A)9kuaZɂ í{m[j~6b^c]L;si݃4s{J'!4MQ` ~AB31f]H.صUb^L;ūoUpnh^7tl~ lWЄ{TE2m]?2`'L0& (ujå_nmƲzQYVfM/m)3kQRTin`ܨ^>|ʩv{74 \ ׀JZTbEs U@:6Zx2kc[6a(.Bhy9y& 1Hv$`ߡl۽OH)ƳGfkz=(h۹8R\[7y`ґN05f 6֫K D ]4!j:vI `qW生zc51R<Ɔu@xe3kZ%_Lzy)_L*GHz[ ꙾P(\0sEC:[zNC*~.z <#_ q=f'XZvP;E',+I,OWo Z(׎.悵k!9V:eșň~.$oz6+q&OFt4#$m-~SSȪ/r*`۶&ރi%{{%uOF18>) qgI]6hʲ:EJMs Dj2Bbt8kV6b&c+kq_h'D/d Jo@~@qO-'-d&ض{*oEioBe!-V=%yXY؎I<%襫v?3FcBby9]X6TN%`A޷fo5b< H!s9L݇,]Ď^طZ=T24|0B$8}N:{mET:>lqʖe&Rޡg3FaCu^bcݹKs>hi1P-9 q%u l.+.Sj(=՗L+RTX,юTݑw7K33 "φw 4D{x~lXw8Ҧo3|2': ]h*UhX~ [yoi:XTUL˗sXY}_(<0r@9M,(K,550(o#ꫯꫯ14>:D7u'sӑٗ¡bbuniz`$\neyW3ak`xo[plyobr?Ά 2afΚN2D_ϖ-[ӟĽ˽[~\| dW }?dO^ĆȚ԰)S}&N J_zȎSNՖ}i\u\OcBP]=x4gIEEhnn;ҏ3gy3ℂEJ'uDoA`\tͮFi*%J{סa*C.^3*녝ƺ>ѼsnÇm6mH_Joƍyܼ#Gc7${P` A Q9+[sHEW.]s##%mL)p [neŃ@W4˫yu~ :[YG@ r m州xpص c?{T!uE?/\?"W^atww}jOwsXθyn+"K93omK }N^|܎3%5tP_=!}mw-cE}e>F4by <}]{$'_wWFuu V!"ٌq E/j@x8W}'ud OrP/~W;!&:~rUW]wq\3;]g~(̆-KVC+Kp |yYMO.H M1sӱ'89Ft]p쪫Sr4eP-&?4#wOO}b$q3m9s`δڝHi']٭m;1` oҊ/ɒ <*it.'*(\[>\_=V )>v1)bVtݠ-#<ǑSjOpe%\y<ϐig#kjzuE3Jp71F}Eif๖ %5!B,woublKߖemb\SH0&H{xݼtoRJj*il*Ō 9'OЄWZtKZ*PDT>I ¾BFkA|{l+v,Z *`6cޗH&]q7> [o%iHCp#p]+) ֛ Þ$is2:bY&1aINɎN$i㡦FRS6w^e݂j.;ws NdH߫"<Sk0z֘f#;jjjԗt 3l]m4VE^䡂zrLTHS1jvcԽO?_|1$Z=κTm4YckBxKvsX xg뿸 ڶ.hR w i<JҹLx' 9eYl۶ 6|qo mFՎLw蛨;DZI&VsEMT 0i؎e[v˶0'46Q' P `j/~]wu9!>6NQb[>O#~Rnvlf6 N EOp9xa۷`Y[nI+3#O$d?e%EvVE0dLIJ$(d`{~1gȟ׮]???úOphNGҬ1T"J ah'[w3z6m݇{h+ sޟd/=;*+wh+}78l?&EBwTͤޣjȲ(;-իWs.Z` L7xhlQzq,J"jٍi$ -Бя~tTi֭[7K/_{;M'Nj]JM}n0jIDATˑ8$8'S?]wwqǰxƍlܸ{ｗVxLv<Ӽ*1k|y駟g(mgú; ZKDE['*Jk V/s[XZ_x^}U~ǰ;4]s5| _DP,] Ңo9^z5%6-ʆuw Ü.ul3xt.0{1z!~X7]m[f跿mۍhix/zRiy>\ L^~>ÕF 4ر7;qǿqO sRQBU k¥HP?3Ċ+﮻2 Jo*^Ӿ>qqn~\?qBgJlt-Ji^<B~M6zϡ!s !w8YH'8myU?VP'/ C@>{ YIǶ=ƃO&D w>yIBF"u~/ 7ɪ򙆏W'y?OIQ%%ɋ)쟲_/lNT&>Ȇ<j9i'*jپ'X svuk&:ڼɌ|s'y4 )U~Ru܊1pk;+#$n{}%K#r1u<$Ow%5,t2}"9 \iV#ͷ7e U.a~3Fկ>6r#. 1Uφ 7!/jfO] Fе?Hr}֭[sުFME}"5nq.1qiv,w ?~d=-?tɂ%sVs}|rEt4җGB )sqse'ugތźH1,K:!l R<,L'},Il8.$舣0w f5,/ID2UB6?RE3ngE{{f^|' ZF5\|AN:$f~q=3ROE. I+i%H*ns7?aWNyt-@4CiqugFbe,GtP _|,V7r9өT͎=uwqo*3c L32b1f\Fq%@'οm|-vU$wj:Ѓe%ф &hmp'$9IAX弈)CeXBf /D׌AMeSOWQYg~mv"޺[$e`]tx:o[U )56eERf[v6Zx8ԋ,╷OrOrma-ZČ3kAylONÇ93幝i`<"oi3 b eua۱\:tCGוgwdqn`ɒ%̘1+G}P]XxB/{.NQV7My6a.5SI')(_dHG)}NJ"N g-/ΈQ/ǂCKO~,^v***(--+b,\0gj3/o]m|d4z>0<?c2 &c}nVIO[!ޕWLʌJYй ֥NDXxM *s ܧc l Fkb:z}'i+K+^oVI5fmv *47#K.snN%1.vc>ZH;%@sҫmjth:HoAp)=yf5!x9+|׏Y {s "e%"`% `,/T #YKUiH ᥷}$T t!4^ݦ+?J Jh2h;YQ![O KF3Om &4^y%N))Y %!Αޛ < NU^HVO^8RK Y>IJ_L%u#ZgxkW^:?8HQQZO$ToU[|;ƥhe%S"[ʧ I  `7BB W}r̒ 8IۗcyDj:KI@Jc=JzK:{[(*V]N@QMhfƴLjO?ͯFaɳj%%H+uH)oۆVl6䱭*YW~|j8ʳNJѶjsJlbt'ziH-pZ_5zڻYX2:ҺP$p yr}fP@ɳbH$m]-U"2 eg\ü+]_8gCUsT2`cj(\@vh0q)%ELɟ^@"WzH5yz'u)M—VQP;̚z $k]3v24MGJIGaS{meӐR2O?0. WwYa[!?}G'/D WꌽI_I>5h<&t4 _G|f^lT奪GFM_aDc=l ɥӑP BhU $~NV݈阖Iw_kVҁj|t,{6KSt+a^s۽`IUER>pާTW@tB``0Bp_ö-|<?:_.Pqp)l8Fhwp+$0 "H p-=*筺]IZIzٲsy.&@Jdl_2*pF05c pk&Rs<{UHo(]vZvR]Ot޹Ex緌>#µ5X@K?_2qCwoq.(IENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF_ U_ꪪUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPRTJB*_¥II5U/RT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$WW Wf#$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???]]$??`AM@^@`.@? Z? Z? Z??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14I-PNG  IHDRc IDATxw\yM^Z"iWjHB*H m0B `;;q8'qjKA -jwv~{hlE\̽}=}W# ]3T1M3p1IY :=C(((,=̻4tx¶lLӜP29O =ۇ$s|1~)WeUFq[ qLa;hwTH˝a!U'VrڜJL-~*voBw\fp ˴whhw`xWSWa_\ˍwm[iTL% 'ycP7/le ba (l/ݝaȳX{/gwdžcBvw uIO v#\ Z"~7,w{p=#;B2RVea;&/XEۈ(͇^9pH&'rp\յq\MXPDB1F Uxyka(7JbFAUU. j"EWd;)39k' `&+cj*v ݲR؎mDeщgڎ'n Ǽwɻo|E Bw=uޮ}XDwhm&*˦4qb,;^:px}g}6gplU@)3xVZu@Ch%g~tǙͻNL; !5lgKA*JkI TUglR_q}:8ѐHu c) 2Aov^ e%Ǟ 8v>={w$R]ضeǵjn =fm(Ų+Gdbv>s T:+sehw-g1ZQ:] !;{ƧH7ҫh".B t-h kno ^׋Bo/wlgLD T7PtYh iFUYݘ'PS^2]7A9pxGso&c-ϖ'bhh@cay4M q_q䇔'!+\tM*؎E[adY:BFśbI kju^\q䏐 dt@U4Oơhw/ Y'*BE%aeGw$h@QT*J'1v0ıdYi}2WNI3<QTUCVarX8R._wH'EpO'#dDP՛L(MpQ훞p+8iFaȈ ! 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1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF^ UUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5U PRB!R*RUV ZjRkMUkKPI H$ $I"$HDB$DDDI$ $I H$"DDHD!DI$I$IDDDDDDI$I$DDDDDDI$I$IDDDDDDI$I$DDDDDDI$W WfW#$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???ee$??οL 0@mӿ? 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,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FFa ꪪꪯUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUsUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZ PU HUZC_I5*HT)BPW֨P֫kU ZZkuZ_jIA$I$I"DD"$"$"""I$I$IA$$HB"B!"H I H$""""""I$I""""""$I$I H$""""""I$I""""""$I$WWfW #'$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???jf^j$??`@l?r(@?Bܳ?Bܳ?Bܳ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 169PNG  IHDRc IDATxw|N$luےĉ׉K|i]ڻInvS{|8ű7Nےeɒ,Q( g?ޙ@$@j 1＃y8B!˛@$ҘUeT.%~_1=<DžrЄ ihx<̖]/NyLpY7:RDJiHi[NyMit+Ͻs(@sqGPRT9edDJ}R O;qZ9tCǥiuaB"<%(.T@mso<"Eu7Ni%|ޢ7ei`s/|bzx=^<^ۋ&\<?hbsnW 8q#Єkc E$p{Ki@jiJy)7nȝ 4ͅfhhzqS SW}˒p'yeƁDӲULE 0s! ̦}̉v ChaDži5R.]g{/[Os@"e1k+vr:͵sT-D|v{X?n/z[/.-;}ٷ}|BHH%&%u e&[wG㦏E\rqhB044qop%d[ɟ C["ȒS,SmAUn !2]rdr"?J 1_LDb5qMʔ! 4\l[X,C;фFFuy#. McmX$s\qH@7DcA:{!ݔWǾ W]k햦ˋ&ityH$/Y%{s`-$} TDoDc*Jqi.4(ţ];ޱPF,0tz:cSXPHAa!nx< `Pptdr\F\.'! Rʮ 9-W \|?g\gW:zg3öJBT;ZBH%wؔ)=Mkv<ˮoyMoi .d(/ihhEO_G 3  DÄ"7 "Ê41=K4jp+I)i?s_ͼU4:μ /bY&RF-aSv,:R3=R/s^UTPEӴ$$HPaQ`%#}-47c7{o!:RIxC:HPth,xg-!D!6e5\n`27QxVC]Ks FFDa2酏&:UoZI(զ40Mԝcq֯G_A7; HXR=Ymn4x~<38J{_ck{,Z%n,^ơlmo39? bkN!ŗЈłDczٯHtOHp~f!nĭoP%΢8ܻ aNRLLi:r<|7/oaN H֫|I;eF&c&4J*x ؗx guK}\v3L `NԘJU8:2YE̚)Mm_a^JK)cqKswg<;f_EiT\X< 4֢-3ز6BJؗ%nRkۏ)Mz1ﷷn mW,sk[,Uj׫n}z@tpRJtT7:)(^J*! oTZ{_uM'rAIQe,朙UCC :cӹxJԔ⩕ֶi1z^>zmkwaԿt bF| P\XIs\6mʲaDcf_Wy< yAk^ fNOFiQU"IHxpcG]KdE1 w#MW^}*}C*kt[2lH eT5q2fK i$H %% +<${k__f]I"{hb};ףhYV؂v1R~[9qR4Gy?Lz[ M VuU E~ ޗ/pWx|ÃUCc/Kcw&pw/`9,+[84T[9kf㢤$SZ# t&â9gZS4 aus/2":TQT7 F(:}op on?4 eWVX֜v%H+[IYEoqa9UeM@9E" Sb: M]p:u˟6ռLa Fј@GvRyWHxGvrw'l# 0@գV[9K/VJBcגMi;׆%l,  ܛx OQAH)Ybj*Z0A`'-H$?iI#9 끕qS[9YK׶9Nx<Wr zsP7BwGYxÅ?(* _KK Dx&4f/0u*(z@F{_;ו\@eQv%K^gڂV, /甎ԟn^Q[k0a.Mk…f#k 2i 3q*J8HyI5q#Fgn*ikZ|.+eןgl:g =Ak/7wNt|Q v ճp<4C=Fl>D4 `Eh.xށ9gϣ#LWSWQOE*(aQׄ_{Cuq=J0 0mfhK.n.3!g͔TIʤX36%Z,_x1*!͛ |E"Ғ -,geՎ/0ty4ŌwO[?ʘۿsWRb8H8@s0o'sZvرCmM|35lҥrMd$Թinn殻'DZQ3No B86SZRI4wBJ3g?e&Xa&MTf3 ؼY;`{:rد\mٲ(a312]c `Gr_ntMcj׎[90_ԋ^+_ :\g ͑}l4gUOfq<`C7Lqq17ro= ˗/gƌ̯ a 24Ggu$8dWՀ|m۶q+W[oMy+Kq r{w=8nIs"%@ +O=O>d} ޽/~~ߕB&R)/5-Ee[B'?qg!~^6mO|+&i}pǜ׊ i,Yv\RNjCD;< G_5Rڄ缵aJU`p;|ғgժU1y 9gSfvRKdN)-JyN:V8fWTť@ /|;３}QVVƣ>:b{}q}?/|s/RvEǑn^J͈_(/}r 8e)6'p iv%b w~Daa3dH){F)9ÕW^9ƚ9hX"}+Od./NݴclCt曹c{s'p5_"s?P3[i%ikZoBa4͕Lw2?۟ʘ8X$5 NO8T=O GF|',ulRz?s>&M$g%)i7'U>q u9C<j*^i8> {Pfe4Ut rfBgQ\Tc/slܸGgBۇwPSS0q`p4 ULi j^GW~B HO1luF3O;q]x_&|ǎ)SPцj) $eO"#Xh~UV|'t;>zyӦ0A,D&>G]1D'/ϏZ/?ܾ]G_~l| 9]NP R^\IHSDaD|hy##1.?% JE2m5 faFبGD7'*J ^2t ^ɭ=|Sy+HZUDKx=~t#4uuu8M9-YZ_e"Ӳ`OA/}-Ud+]B4&$UHn?^z͏Yiӣx58+]DEY ^JOIDAT q@LJMs1_[DUY"cǥ& W9eDbaՓ]*gMTK*xlĮAX=pQEj5G{Z~ ߭_z^ށn = ,I')NOlZk ^Zqd; qpiIWg %N+dG7f±Y.gnoyHKz3-s& HcV8w}H\hk\έJq)qH)昿 GH BMɣQ-i4+sS+R7d&5iYFaR#VCIRm&o&˗/ۘB-؟GP'EUEx=>4G?msɨ*oiyFz\lj%mVE4zc q@4>Q 淭_aDc!Fz-3h-If+H/78%e"eʉIղ&4"V PVZ VUZWUK/┙ I[u'W:47t@iA8ZE7z@o\89qu%,TssTw15ځhBC7b9gi.GB(p\6'n&yFz(+!GQn8UJi-2Mh?d%ivAhsE]e+UM\nbz%O޽pc9i3;.oB7uʊ{ 0qSw(tvl=UH/^@--;.: [ԙ+FB GzqME ^RXh"& ʰƥqTgCKO. E 4y<<&ٳgOm.y>l]6G\#Λ rB28mwh+\gg^1?9߀SKBE8Lf$00ry[)>nI']86,YoF0[aKP]8mĂkNGJ^G՟DCÁɋ Ayi͸(w@{mҟD$@/Rz~gA0bRJy"%%%\}լY"Icc<=0 d<<MI h{OHà s8pGF')pfߴxVE0@-em$hVAýRZZKqFNao}[ݻ^x͛Uɗ:n{[->o! $winYw7S?w"hm\@$nzYtC'7t]y jFJɡcjI䰥䵭Y `,WMMM/ᡇTyCUwrn.>O!3{ReۏˊlmXё*%ר@v=N(`p^MҤslN (`tk;JJ$B 6Y}K>a˥ Y5 V ^9MA4f6.FES#//^{# FK\+Xp/s&Ϲj{.j)ȘLdx$ C8ZRgvR%|&V.4Y>&SH!q[_))Z1a~Uٱo9bViRDSbP>@A/Q#x!!RɲOT>h.7h´exg!1oKμG_Zjr|^UNZ:mgߌ4%%"_eNpVi.Ǣ|NR_) '1WsnLJi`q=@@,i!0KjiY1Zi.[i _y඿ᦩgUZhPn$ PRXI |1Mh,D82L܈Y/ T6ېVj!0q@%=GPi4LiI'I^; Th,O&p %Tu-Nәʝ[sNShܟ},Trw",vS׻. +_69d .tWv?th,/2X*=B&H,UxURkov.AP81=tOL~;\wŝi=ácΊiL[/'!'UUޤlsˁ91unwpVڹ Hi70ۄ:iYJ4cٹFǝؐVaۅ!:an7'=,IB=%JBbxcqgN@ %91{=~{mo`8@,vcMibbE#Z4OL8u 4ӟʥٮL nk9Z- 28jUدE_Lmq?sܶ&9}UeK9g:jZZ73]BVEMs9x@&YZ҆Žٵ-;G1R:lƴb!]mZc6OzU~u\SKY} i#ThΙq01U85$=~>IENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF^ U_UUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUTJB*_R֤֚]j֗RT!I$IA$I$D!B"""$H$$I$IDH"""H"$ $I H$I$I$ $I H$I$I$WW Wf#H?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???\YQ\$??n6.@?@ZS?@ZS?@ZS??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17+PNG  IHDRc IDATxy\Uw=$=HA@" # :8(a  H"K $d]ݵ{oUuWwWwW[u=Tկy(kTF@qQZOѝ@A  o'“&_ z LTSm ,&PV\5nz^mWչ<iҸZ;oÚNg*2@MTUCU!m !@Q{V-ko?ê̕w ۏōȒ:6 LKk K²Ml¶-4pGLp}_ћzbhUqNgʡ UB`&Ĵē1 =@0P䩳y7ƫ ((u3女1yh6-;S&eE@l%M#ZC _%u#SgwX[!ۺ{f&y ʰdgHTQ.!I4= !R 91$q>W?ۚ19k4V/a8rv,L+/}Ω;hq5"!B8 GOIucZI,+EL6hȳ`JJ*/yKry_ =!z}G3<=Z/0!Oi:"e&x_sP!´R8–q\M'ǽ%cc٦2G_{F?NqxUjY TG'G pp.ZI=澵M ϼHzBGO3NXV M4"GA C(XȎcL1´@QP\(wUI@_:$~H/9uz5! i̱PWEQ%qA#L(XB(v,6my`~V.9?XNHIq8IٿBJEAUTE͚Ա;oxPU=yN[UP{z(uqId{w80%{V]Iuld*NkA^AjB`1A#ͦf](+EfG2G"K_#V`(9YUYsT+A@@֏)y-ضIKA^xU5"0 yi:y2>̤'HHKNie9l9ii$ :M{i%  RFG蚁/ƶm95qƻi>:.i$@k0ɮQh^q`Dvpc8km4b iD涽| U2+ ox|#wPV9{( n:wQw,#N|6bۦedCSu œ_/6'gANK# /ņ´!i']@MTEŲMclTȞL;4o-SFq8ru_&{HGKAf.!ʖ:U} Ü\?>e~>e=WcֽS)CF4Uqb;m4.8xl2{֒gE|t"Ӿ챍HGZ7>|1%b ̪w7wO KqG]_x;`w#;BO1v;cdc}("cxtL|K.oDQTwddi\sK~\419L~Bt$b m2ٷݺ S`ڪ;zgA0tooWk!P*Jj0}nts y$GIԁI<~5ő(9ܲ{23axMY'R茵+pn!mI>1cR%OE,d"X [v.&yWv=郻-K,=^1Ⲍ/]dO[Js˃wXs:) }pCt21X|A Lx( 莍]ɳv%hFJЗsZt=Uj +}TT*莵[aL:TMߘWX(UL¼j'fG8/o˔)u\DB%2K&1`JEsN#e&H${w>OI躁ɄL&Ά]9_ 7mͭ?6Vw6QOYR *mdl竦 20-)-$aƏ;\y|^T= tMJBIKBI{8#yԝu ~N;GyݻioɜٞB9ʞ<j:<$ch| O?=uzHQ j̫,G11Go /Kt@+0Vf0ϼ=RPrEu?P;_eVA`\*;y;X_\U4֯--keS!" zK$|XߓP;>ߴTw2E4Z(Q4cA `q,h\1^n!;M5PN@mxG04"}A3hi{4NSTTDwwei>zCb4( kvȪRT4ߞe`BOoH߼i_invش)^ 'Gzɳxm8g3(-)ELwO"΃U`A܌fA7`ُ| mPTMrGH sl?1-RAN<{O-憟I,GkY2w5%%B{{+=]~Ⱥ8X|LVz yCe"U鐅`^NW?񣦖4q<$hN;N#Η,\q*.bɲϱJ& ݬPm.hH$B,EgwO*)FUB藍Dd*i&@Qװ<~[~ܯ6+`J60Uc H)NBnfBW,wdz|9oo|c,++㡇>.:gQ|JRstU@weu $y5,R=D[dTuZ(+Wdn)C_T8TWYG&2ʖ ͓i5!C֧TQVRMYqn%K8묳xꫩ4M9ټyxռ(|?Kkk+C'; @xHQ]>;+Uaj+U=HZ:>DYUa" #oy5E2=qwU~ TE(*nM3plk@Xu8]R\ƍ׼2©ϑRqX۷;ӟt悬p }тθ'OѰMթ8/8Ui r6ǹ;(fI?nJ*J}mRTUKP ]ŭw}+(Dq@]2A\J" k0&ֺ5;!HXm)3[~vj] +/wm930oX ?& xx'{nV3GdJ 5.DZsk/MRV\IeYeuzcsR__O*;2 vuI4"˱8KdijO-E)8nFYh1+,#uv~VF;vر|%tH${.y2%^l"w%XGQ֮]Kuuuzu,sURYZGe~s< w^}0x%v$eCcbi&`1}C̄_7iƱK K#.a٦o?\e?qmۖ&9ǟ$i<\ \c&H4{mOp*H[RRc',V.޼b==h8%zԇe)04UWUf?kx;L3'[ uY(:6JwJ po&b1iM[/v9Yd [35KV] `)t= 5ܠOq4Mömb]RV\ ܋l"K极ضEeh䥗^b͚5,BS ,^8 (HAiòIz) !7vl}_ooJ;ΈB%2h"֭[ݻYlH$btttF,}i`d޷؎%}tm[86}nTԏɒ8F04Ïv*wZ(Ȉt:;A7X#RUUU> Gg}F?ж8Mlx}n>ơcyW3n+}f_XEQǶMcFΔy֝z)-pjFllܸN3g7H)_yΌWݖ^Umw bWb~ eO1JJJ8|>9m@T!%ƚ.!X 8<2xNzU 2R ߏ|c;rg'ߌF~!yY`m!̡Cuh4J4*FtttdN9k ؂ F0E”||xI,|('a2X(|b'vϕW^dKGo~öq饗d]EQY2‘¤,ryXଌW%F>9ݑJ;JSQ$+K.U[#ŬyvLJصtQ0{_ttJ4/H|rl{Kr]'2DpWc FEhJ$xASp7:YFΞ;5GH=\o~C-p՘Z5sеBl])'yP FNqq1hW^x]i\x09ӁOQWMqeH L+i'Dž80U%?m H~xk5F Il朥U9?FU53Y؎MOR))yr2G/RD"!ϯZz> 5d'Sʻo>-[O|39؎嘘.i,;% cLi˫a? QT7'/><4rrHq≞4y_m|㧢;ʞNAN}@*?x𠔪˗s饗hk÷A:W1E9&5nQPP2SyD*X@`0D BUT,G%#۱I2:O莵KtbZ)Ǧ(\ƊڽڇP]@[E|g}62E566R\\̎ DAcN_ qIDATt636c!̈́1L*y4|n<ᆫz:ς+Y}.qҤ) @,²,wjqdl 쥧Xvlg͋hzK&n`i˶e-۱ϿHV& Oxg&bBOSn-maxO`Fy2س^!L.~r%A}}=hƣ>:իWJxOGLyt=h(8y;/)+\5FC\8ըYfQTT#pEΗ8{nG40!FtS(c"P0\^#Gpz&֘XkAUe(\6*a|Lss>I:scpDSlK(B*őWe"سgmm5Y^0 3i'  eib*$>k*ԏIB&Tq] '0vt[:>qФZ@J oSeyRhrpw.N  ^]&= sS/7FGqI4zY]2#<y@HUT9i7}:{NH.i1q4L@Y/=^|q4 Js r/W&֔Dt 4ugW'@Ysó!JnZѢ8RNQ*hL?0{{bګ(#`d¶-WyvP_rn^6 r~h:BL{;fyLEtG41(*s/> ڻy Z{ο{)Զu !RUgobX\\| L®|h1<2L.QB׸<#ꨨz*`7Ў$]@wbT[<~-|1c$x&{`6WSIsgç+/' TPZTEOp& Ϗ=,ULSuEF>QU Ja戶=(B*0e l; ^I[,#=<\,jQdU4GVlƐ',iygM]ޔI%| XuOvyClHtsjg' :$R$yVqv1cW4UG鳈rg&CZUD<1l37)+"Py|uU TG쪜K_X ,q+y>MW/$#9}14fyK@~7,"`A()3Ao؈3<m^v1D6Iz; RmF)~ɥ3F`+|ctqd DM3f y· U-+E"7kg y/UGUulG5=-nQ^uϣ g&'Ǭ60B(XIq{[ F SQҕvݖ:W \ʹR1V8&T߄sFCh.3%iE2$>,-wdTFD@PPפo&Ì#id 9?% eN)SOsub.ɘmwc27)5?7d;jIENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF^ UUUUUUUUUUU_UUUUUUUUUUUUUUUUTUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUj PU $*R!R)UkKPI H$ $I"$HDB$DDDI$ $I H$"DDHD!DI$I$IDDDDDDI$I$DDDDDDI$I$IDDDDDDI$I$DDDDDDI$W WfW#"IUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???ww$??@ Eտ ?̭?̭?̭??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 18FPNG  IHDRc IDATx՝w|չ3E]rr{mm%6= !!B%7=$`M3rSz]m1ͮdGj̙<眧 \`[BDٞ"Lَ(Ȓ H =!%9: ]Єʱ3%_[~x꣫0bz(voQpT~>6p$$ PQS .@"mY=Fs{idmiѕh(J7y2tkM.^t/R< Ceh#@B9XC'?ikae1˱ӟq|+iDŦ%_T?0lDQY{w,FkRk|ۮ9=yS6)-ۛpN6{}k&"CN8~v'Fl'fz >Z3Qp2%_OCs#i+d5躆.4BX.u %زp؝UýJ oqB],ve׎6!tQYscgw4tfƽ֒n^3 x[8{0=B @Um/t]̠oTJ׏4 GΜN#\zk'5?jK۝orг[V͹?C wѷP|A/ eǮo> pä-*LNXɛu $@߼q nwr \jdz=o-]7~\T-݉,wݢ#NU 7YݘSh||~7oK4j3 b^o!$#ƖWƖVh4멨9O\#˲H0bAU B(T5DnNaMJs_0bp Yd+$fxꑐeIHR{Khrג\@ςϟr ^O5b9UqCf[-yc9qڳpfg K2了t\jmgk6r($Œ  Byǀ!\^x-}G]%OL:>2T5{Kee;W:c rzstZm7<YRvVQ/F _$u]bڸ!PGAH Ҳ= /@L#5L*J_Ixͬ)tEِ$$4M|tql6' zMQv3%Ñ,-ܞF|s=o|v}S4 !RVǙ.64 6ن*ؼD"pJWÁD$UZgIdͼ[% \oijc7+.o#=[tle!h%w±d B"Ÿ|/ 1V=ք|%Ƙak;5}z !QTunȅHL jEYQIn ##bGuݵ9IJ>|~7ٙQ:%<{Hڦ؜: 7{>34E-q[ !Q2~)Yy躆,+Ƹ`FåECeAwʫDʚiUVu>ΊquN0Rba愵B I _u]EH-eǟVܶ'_BVF.&>=j6yȒBPYW#REuWΎhیu1]x-EK~_Uy[Pwĺ_a@ӂ ٙ<#CkS/MYxR}θM kϱȿntΞ;Rߗ. ]Wtp/c݄51Nbuzw=wsTI,wX,{*fWRCg/5OPjOdى=jl,mS(mC1꫆S$/no~o1tv#G籿jy\0}*YƹT՝4~ןf=gzivױj %38`K,gZ_Jh7=eEQЃ}Ҳ= 8)!a/yG0(Vjvm^{EԕF8&>g 'S-HtE?&5c5᮳HY$͑Rh<$¾ujຄ$Ki/;,BZW}sozx[l6}1~Ewڄ$BXb\ANtmF.SbK-s7hFVgNX~-!!)rZGBBudK.ɣuԹۯ9`UUQUMۋ?[t8QZ#b}PJT1a< @pdj1h 65“LpYAeM9f'Y$a[;^F5d!!d4Mvvپ};!ϑGjȰgag #F2㠓mb6aX6{Wgnm8왝کE}a;4t]hE`!!?ma@Q Q#sAyUt`uj F#m6%W C,}bg{|iaO WY]I&o ^R;Z>/ jx ~0a|#GOͲj>= T}pd0+ÌafS<p0 kRmb+H]}ObJ$tRB$T5A%'N굇k<v ""zjHN\a so 럒]deq|-ދ&S># ϰ|: =tiV"5ST.]d[#!>U=6Ŏ$I>5~^}Bha9i IrTi 3g\{|?`+:~<44Wb9- {ޗ~c~i|#6]4m $I¶--#M o :vƠ1h%ޘH뒙)UZ݂](D6sLo~Z{b>>Oi6SHHFD=$N;ޒ`?yʶr:&*j,29!sSAH@>a$Rwܭ{SxRZj$X߯X- $q(<>j΍HDEq{/S:{0Um\BWfь7oǍסI0j4C^NO6j[o@2Lg.H7IP"LEV.[~¿ڬ}=괝<fw> GZ%d8x8Tjm &\V>Os=yN E 8pG.3XRUsn$DGeQ$!&AB"Ѕ-J|ӦM[n/r^z >is0-QI#"j m)Ȥ#I0,<'m\ Vξk4ɰe0gfs(I%KQ?+f_gRv}f?yi@Ղ4cw'NF.Deo3Hkd88[Ֆo kx)9fp䨂,`/¶^'?fنi $AoU3GQFY%8Lkǚ6@GRţ;+3m{_@$fNXUK0ݠ5Ul_#AՏ?К,~5$`Hq9MKN Qxm18z=ӓO>͛S)6 ŸOW`֤x}nǭbbC½ 6~IeȂ~ $Zj 1w,r GKbi1ϬhO6<|yݗ{xࠨcyyy) B6NNbaxn~#PPfIW"+3k|ݖ~|{!L@lƶqؔg_H\r%}֘B.B>]boL-hr_سg7nL 0Aυޜ(6 ,ǰPN{l3 5G3I8T1B|ءBEQA\諼ns/aЉ7|6}ȲA^Qsv;Iof+l66NNv.9?dQ :_ RG(LW &w-^'榣r G6rݍ¾#t0qv˃WVE0 ^| ,4kmI?̷m6.j"yvk{7awb9)ņ$;Ș444 xxk%֯_K/b{YR.$nd82AhSUw*yQp G2ۜ( l3p䝐 »KQa1ami м)4WkcTkhh =Nlce+fo!ә"+FI6dB3SĘ:+f_V%XR bȒ[\IE Kd X1k)(#֑3"Ix!2C ^/JlOT͇|/qڌH|;G?%;3FxbNBmdYy&Zm8ŎM6~˒bfm@ {@UZ.Z-T֞@ ȾGAB]r\u&3U3Y̘AѲ+6`ՇpOj'BaNFыaMj՝i0ϚSlm˒qM7JiI? 'ӷ(΀˖+T5SGO=(mӿ1ӍsC4sr_]w~vmot_|%6Ώr_*>(/rS *bԉX2][L0 j]י9am@2˾}ΈS dB|o.}4X^u8ltkU,`ժUO+WLh⦛n,kWA pFo_"X<*[K~4vr2BHޑtu|KE_o溨=cjӦMy <_~ ~u)fLXT֝l'8Ku54]EcCtODnEnŠ~c~c]oqk_(HlXxظI|;^y1o޼N&nn3ɉLpﾘҥK󠙰~?40)^٪'hW40=V.;hj=C[ (}H?;lLzL,ak!ӕ:` 1AJE)M/buNtt:iiv!0Vނ0 <$;;6 eLv|s}XēO>ɍ7ƚbs6[\PV]B}~8a1;&QozwÞf yضmS,cw]lO!r(lEYB:Lk.KR42$NCK5Ggf"|iHP8-U\~}FA/>c+"-pv`lY0ߦ\7=/r.,T-H3cgvrRuDՋSmڈWk.O=<fw̬ E3/oA֔jMӷ~-zʜټRվ8hٝ aHlbu ƃFsl-Udf9ǯ™'#ڶcttΓ#t^3'>OFl/<>VFWx5pG' {C~]l/M4T gf)?R\IzuHȲsk"D J6%_M@;},J~GB ~0]Eh'CfZOUU%v e{)]ٸtq]>~NG׮? 2m4bわp) TVx׮]Jóf fLM ]ױ+>biɏ IaЙiy!pAgƄ5̜YQ|2B+jMCo&LH[^$l=}!mY=H$reX5q=l&]]ā$+Q _4Hwl5U`|6ƭ2%ff9i#uR3m+c9_b*;Jrt.b9N J.G5BOe3Y5!O=f ?|^;HP45ס~dEez͘a)8a&2xȰ(3|jCqţOladڊʲ-L=c*j#%2|$& _%瓴se<?snh$Z \5v'@+5 g=FrF7,z Cm#Mfs9ٜ(VeFZ Iv IEe:EsusǾDz{oϡ(fi[1Bg?. fc@)٬:Jc3sXc=ƝwƯ:v,45'ts _`mFAY2vMX9qBt;?.m6FeM §w}Uڂ`҈xd_MPx=4TNZ/k)<×zU l=m,d]):ů~+n5qɣ⩏:#?@+`+M;aChxZBY=2tRpuK^8Ndf3XL;?|^XB˃K:֬Yë[vSW7s>KRmƨa]uޔ;?KgaQ6l_dɒ%]!b}[qmC#&jK}Wꪫc K,cnaDuB] 08.is3]ɠѴ ⢋.+K=}jXk Br(Oph<b>v.4DhDY!pVTb巙8n UUhniT]  s쉕s'ӑ W)ȊlZ( @ ʛJs3kBAnoZ.j#it|T ӏ1#cjC!a P1a-4r>{H <6grAH" "m(]NU\?ec|^zs >hG-2>{»ָc l^Z.|0!#I 6Ef3K,B~nolfu}:ef䠪A^zWitGz<&߹+,3cZ܈ONplL-\ ^}Çnȉ=8SфU\䛜3g+V̠;@] i"<٪#qba@oDЬ&W u'ivՆMI8N2YdgзlcTP6n5jC2f{.90Nss~vs >↍?bȠᜭ<#")?cO<}M6e3$4]EՃQ?⒥DU*hrX"߫ᅓ߿VrVm6;?/T] ~Z3}&|^ٓ60H4-@uiZg-eH)3Hƽ'}7(&$ضyɩ*lo8/D: ͸{)//&~0^<z>: BZg[YVKZhӻPV3-֊Y[==CUݩNDy,ΩSbd!DhhjfOM'0waI;>z+FR_~ h,\qϘ9}o}^I BZ{~_ p$H|E?K~W$_w\l^2tx4-ړi+[+Xj}y8&t ;iZۦܡ;-( މ;fDs4D3?7}$/.0@P|W6~"5F~NOs{qE$3YmAGy G ʙsS@Y$P]__=e'$]4J̸\ L$~'KJDuoijj[灶72kBnŶ@cl!Eq3NNV76i\B7j*FC>yS(JjH;0x≔ FmD8#ݰGHDssz){[_ ꛪMW5!bn X;jX;z 䉗Gtq6F,(XlDK B׷^?hҝ|ԁ9hZKǾ] T>̊+)q88]o,WPaR:{o_b}ϿM]OIp!4jq𵰅:D=o%`tOLxc7U~W7C@=QZ=7>,9Yq nTP]VO!kͼ/̦&T"|rm3}jv~ 0S``Q[?&'/&/CmwN$?9e#C7au]gA,΂"lT$fi&Y}S1Uta߰Rg'6Bk` 0Kg^(SYgȢsʫi׹fMj5@;B̰Xfס\5)SmzeQZ:5H0 +03~Ҳf09lkޏ8WgP"<&).Om &(OLY{;u͛7OB;̲u4%ܵ]4d2:>_{&XH3q*ݚdo꥛ Qd%G=V͹(_%D?JOYc<]QTbɌk@Uik3ɇ{Cgpԧ=’xogႪR|.v6eDNup_gN9Wk!8ߧO[v>Cɘ|v[_.?aL"_{t,B\{$c;1x#9=i)9?#ij2TyPpw?C.NJ$dz}h¨iDtq3c$c VVB7Rͅ٪) SJ)roP Mb|tf63 kƲTO6! #+Fb%0 x]>Wp?iPUtc}Ŗu?=@p-iDu" B^$Ϙ-üA~/Y0נhёøX[wUM-r%dAv}+{$.GxMICS4)dt]86󐵴GݽԌY$t\mCg^1t ]o˯a"B#d "IamO xbs Q2$F^d rk=\azx?'fP17Hy57 <`;q{~_l˖M~^*kN.V1ur@n:NUBwh"ge; H"1jpUIC'?j`FJ6ʼnȂS=ږBi$gRVu __B^o/.fԨ>d[x2rS Eb%vG'ȫtU:$$ZZڬQ=C̋OiQ}+̧:hԅiUu'՟q]HF#*tJɦ#wm@`ҤlJ:돦OsK1|:Տ]/8G:Xg#?>mg1`ʘm_9}z൨v}{ M-{56=] CcLxz,U|=xpcUDVF^{võzpi+;3#mI5q=,=u`JG8JVϝ|#"ɧ әHy73x2*EVZӾg$z:tG I ס&`S-_)#DD-o-EӮ42I=ft:!?BGOA`Ȗ3li_n2|y}A4zYŗONVSXNeIX&F  +]m|,5l/s7Lv6{$ѫ[!=0bvùj3SIfw-Mp쬮#q /}XHvtSii6c[LMih /2L VlR{נsCF B}s%{Y1@=Z t!0%r^*kOo$me 4Eӌᅓ )͐˖mr] Dv$ABk!ޙtI;ЬHj|ᅧYRVz>~56s"Nf͆{ChBAKd k<=?BUU222សlLw"PHn VT=Ԓq+q82\Is5ME!dts\4QG 7!tl J0$ R o#?!WJ  g>4]'ÑEA^o]_;"$I^  ^jt duQc ~Q^UM?mV.講eنÑ_x@kXZp{c(-wt y2Sfm&ؒ<5'cEcA)6̭ƭ NOxATY$хqtx|-MW<2B^;!hh9ho3^>]:ЅΉS0> 禫u~ӿvPV}0oņ&edY@m#+#島0"*hr6qRcom=/.XS.EQvy_O+#jKׯ?+N8 U ^eRI ,-k,e,:~`9gwxm Kg^3?+x}.LP:+1vN'C )<$SBtu_/Sܹ}~vS~D/r5j-Wy__,Ê\3ZMW#G].@ʫ#9}? ]h[ʮļ)1' Ɏ95I4$TPFǂpy G>?{15.IENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FFb ꪿ꪪꪯUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW??%| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZ*U'Z?RPUT5T?RT(CRkMUkKPW*kU *OT*U jMi֪i!I$IA$I$D!B"""$H$$I$IDH"""H"$ $I H$I$I$ $I H$I$I$W#?? ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???expe$??@ 7n??@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 194PNG  IHDRc IDATxwxwfd5Er+nqlc!jPBK$@hۀ-wɲzom3cvWm%J+~geܙsy$pcЙ(BA B( [}LMwa ipZ0r4 BBtɎ u2G^D5 MwT~ݎ2t7u?P]^1QU3f) iƐBcRTܡRF`D*&E%8;N.K ]בR;7mHO@JwёzSU3BcyYNB *] 9HOnL9[;_j(B5hrl@5EQRAS Dİ(&c֌8@s1=e#وƣNc>s fAJiTJAN~yN.s{ qЉ;j٫HKD"ބD`έ_Q865?GW:F-;5'3.}$:*k.¤ZBP7HLu[~<]W-yk3tV}6s']3aH6ÜIW#OWK 6:[}5uζY ]2H K!s<9=*yӟmŏkTVQXvSv֨ES՘VBWBHP$I~/k,KszjBy:>ELT"Nˎ[s+NUTT#:ᬧCjgK|L o[@2$-:'QqŻCŶ2cՠqyTb;?yk?GxX4vBʨ.C:b1a1fb C5u BkU 5uA~#)^L]׌ k]Zywd{9 &+HKesnEp:*(.;IA1ll6=5E>+.u)J \h" F-DJ0^r7~F>x!i8]Ǧŏfĭ9Z"Zq8]v }n Z C2se %4FSY1칒jة=~>GYIE. qe4!$;gu sNn@5v[ZV1K=b O uY$q,'x஘}!5e:HKcӛ -%s传ݷc~y,ŎyI)&(~j NX<w:RSF}GNm,'VKIeMI <7(8ܩ5}6[ݏ?!D!֡c;|Ms4|t]'0 Ok"B'ỳ^ﲻiS^pa&^7N nq4ͅ)8K Gc>p֓*V!jf[!-e$f5 Mw,P,D2/GӜG-bO2|?ƞHځGy){󓟴)%t)+/ެ]}!7U5q%غ5U\r!VmrmC{|g}ݭlIi'VǦ,Ms{ `3lFR2bB?L%)`cY'w,&& /6F!vbOdXo?ۭя wh^0׮ΩSl|M7`Р|04@{nF{/ ))$N: `6i75jK!Pذm{ֿbO/yn]m~^}ٰa ?0p6o>Β%|o=rd YYpw_wzS{4/{5dx~icz ofh:`Hxt]GQ@ 8d:w_;8fyOƍ@55᯿$*΄bҹuU۫l2{P6hW]5eƑ_bȐl޼ ~xcI4ak7|}~=_΄()Q'8`8u$6i9DhmWۅawtsg7SyjgH$Nz{ }&Qᱤ /OVVk׮'Ott4(¢Exp["h~.x4Gkשv}s_=ztsw;X4!PSօSFJ#_Nu(Brus5Kaٱ{3-#=5Ó!}hCRIč+oo_;vti ?o^\z&~췏nAnny@ ׏MNF$»L%6k\ oȁF)@ma ` l+_ PPD7J鮜w7lni"j$ə&+p5|XQq~Ħ[(d). ˞pDRw۾g:h.ɞ]-rԮJ*OynX,x&]8P䳑#S䮻b >SDmn:n[3uj'%k <#Ƙ@mo? ^x u1U'0iBcD Gv vɮCqSTA 0eb8]QTvE9{Al,8TT:f4#XZKiJKkBCbb۶e3lddZ~0u*7"R(Ì/}!uv#Lu)ҍleV^ݤ>ŋyg \w]&\nkfT Ee9x8~W[Ĺfc _ԛh-vftRU|h ہ<} ?n}~V4Z:\i\ӄY"8(i PUncÆ fq㑆ޙNwY_F+gՇKR^c6^س?lڴ'h8E㇜74͍U5.uFǪM \3@cx U1m<4 E3o_R:W=ޏIObjm:HRR4&KhHRTbnbd2qǛ8\\èiEJ#=/^W\5kZ.=w{ lI yezrml2ye 1C:ӿB\*CF?UE'~qpk?qԮJf]>#2,8Gm,3wlpTfTO w{>߬?LiE1Q Ǥpv,h8$%Մ0-Էb:Pk֬a޼y]O>Ʉ(JvvA/9.i)~֜HmŴ*qY4FDZ8]2Wra<|CyJuR=s3BB5~.)fiQn^\2Vܚ\j+p8uW-/̟vg fA"[K8 tمw7R3X˪ ,2ƙIn#^FzGsaHFqkN#œz隱_{8gމ1OH|nicqiZ >!:6G-nzG-RJr0o5bW^\rWv[15?y&vAmGZOki ?Hk$7Vo}s!tb񤧧ꪫXr%M󠵶0wҕ 0}GB ͌!Auٔ<+.A.}]]qL& fՌb=]>`CsZKNaRp _K^-{'HYr6;wdΝdff2~x ߿?<##c+ѥ_0nm㶇⊓$CJɀKs -fbVx|vgjka5_~RW!p|ËW>LرlѨxZffZ~!3R/B<{hzG-uU<+apH$Ѥxӟ6l[#0[XTgބI5f ;3ɳdhV3FUU=1ZfVߟ+efŽ ? !.ס Ѭ r;٫j`{0iAN~J*0esnZ"ё Y#09RLU1c6YZgyG~ uSd>x1(inn7ϛGo`ޘd>jLPkHO`ttbYױ-/SW_EEYʎb 0&{+&>VPW_Ӎ:e^!! ~׏KG<-_vxVz+h}Ne ZBmapkN4Ue IM G (CܸN ˌKf !^oy AHtF={ｼK̚5 /c5 U)8n۸3W ,{k-fvKg}MwSSWaLS*\ng1lB((V94ݍ[st).a'³yʫ 9z*{83<^_{ʥN07|Ô)S Z_ 2{~LTńb"㩮-2jmWrdi*6*0k$Fud IJFl؎ E0_4Fl8 BUM1jj9Ku/avnwK0੧CAؓ,y|M.2vEFFF}5FIeV* "M;tImAJ@4ԃo>麆B݉3k֬ĉ,X?6D &U6 H4vʂO>9~0sxejr=vFՍv@PFUGK %Njk-Fyݻ"==wW__O[|C~ي?ODvn=3 ёFw*iT|`1 pEIDATbTF PoK ̿{9N˴*P|9ok_k[O*\zAC ?[oNow)%a1M#Asv a2Y=Wn$9mo͌3[(//g޽yg5Q'G *J]o @8YRQXq}/|!P(*h9N 0|p~H?-|\\yeCac1q^{cf#66~8d} }ԡ(2`]wDE( nۅKIz#O>nuyS{4k<=u>OF:a1L,E F`v-##]Z ;U^m}'߿!5ZJIxX4UvNR\l+r9zj7[~@i)*gSXv>q6]hQn]v#OII­Ѹ5'HC y駻uګ[(wҿpʪۈCl>7_Wk(̧xŠ~c=ӗQkI:}May' Pc+^<ݷDFF} UU O6.I#]*Mĸ~8\6r "% l_u Mp̝tsH<\r PYS+o.Į]x׸4i/+2Gce )G) pkNʫ rW>yY̙hO4OH˯o3nj|¬8T3ǯ`|\heKEpkGS2|cR;j; PQSeO`.;6{ 5r JhC2Cfr;t7k?y{NwNx+KDԕwy{B1B86jK䁆`HIW_vztdugPQSDlT"i}#*"9̈́@N&;wfأ3?T! JpڸmU`^ȑ#ٻQs5}bHik;MEMr7;:NgSPrT4&4O`;pV EEa5H~P@pĹxٶmN*O FJr|*Qq\vNO_5c.T"#6uθ`1ebf̯`O~X[Pݍpڵ~lTIH %gejNO2z R7y(a:`ɽRLeSYO!igǢ*~R!܃<1Ti4isI2ӓ P|ꯚHxrڜy-sORWu{=<:'ak8rzfOh]j{w}ﯹhKdj 4ڐB+v'z]46/Gq74htӀ4ebEV>iQq8]MV`l%~-wYHycy->1h \STՖMV(B;5m g0an&6dmDbD(mM>[9n/}+K8vG-Wr8'0>9>A$Jv!z\Ey *qi)#zawtqk&YAV ?3~ą(J5WtsV"b;PMflj KOP^PF9$];jNji'11}<=lhe#,85E5Xƶp`>E6`"|SWy>iU9 9U57{V:(1kV͘L,p-QT̠c0 Nw:dAUTt]VΉ~G@aR(ɨq"( qVh-QDG":"%k<BPU[ƿ>i[c{Z±;F*8vr[PU3PDO =<"W*R±S{X9\n7.6ꩱ.':""¢0X & (FnL ]vN5$@ dG0B[U4u`q<49p]|} Jb!*1DaR-(*4nͅ[spQQ]ء3BUm%FnD~suO!9LZMLt/LVH'-&O9\!'@\t榸d^8"bUPZ= ƨ=@y(BPT~)cK̺t]4t@1~KDX>Lbƥ98Љh@fDJIeMJ`!WR)(9ƮCBo xjl> ӡ-$l YfHކq_9#piTńI1{\>4FyP ,p]TuoyHOU>F>4!\.;_wQ(DcXa!9j:ג7k!w4#.Vz{;a I(B+`R-pob  jI ORc(H;~ sծwޠּ7|Qqh{ .hXU* mz{Դ뺑%*[ڃP%qM4[ ѝ1Cfb5WTAMa#Otd/¢NzVوAQI4aHcj4pRGw@Pkjӕ0{a;y_t 9`*â雔N}t1F >] y_-{rQVlT"BQ٫ۮt@tDNS^Uݸ.F ̠RuPlU330P٘3Lu1pS\~g,GULlb0-بN3v,z'D*NB*jBntG!DzBKK`G(IENDB`move=1000;blend=1000;3H83 c cA" PRkU֫Zj֫ZZkUT֭֯V&UMjB?CZԚ_UI Uj5Rj֪j5RjDDDI$"""I$I$@I"""$H$H $I$@I? ,"$BU fmmmmmmmmmmmmmmmmmmmmmmmmmI$BH dI$P$$II$"""")I%I$$I$!I$I!I I$BBDDI$I$I%$I$I$")$HDDDDR$I$RB""""$B"" $I$II( @HDDDI$I$RIHI$B""""$PI!HI$IIBI 4I$I$""I$~binding site for residue suc a 181ac1&) 1~binding site for residue suc a 182ac2x 1vbinding site for residue po4 a 183ac3z|1~binding site for residue po4 a 184ac4=? 1vbinding site for residue suc b 181ac61vbinding site for residue po4 b 182ac7or1vbinding site for residue po4 b 183ac841vbinding site for residue po4 c 181ac9gj1vbinding site for residue po4 c 182bc1,1vbinding site for residue po4 d 181bc2gj1~binding site for residue po4 d 182bc3+- 13KB8B1FF| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(CUjI5U/B? $I H$ $"D"DDDDI$$ $I H$B!!DI$D$I$I$I$I$A$I$I$I$I$U,BU fUjUTI$I$jVI$MTĒI2UU*I$I$Ԫ"5U*-UUUJMAB"2I$I$MTI$IUZ$LUJI$I5*UJUUUUU*"5ʪI$I$I5RQI$JI$*URDI$MJ"#URUUUUUJ"2I$I$MTB$I5P*I2UU*I$I$Ԫ"5U*UUUUTI$ ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 13KB8FF_ UUU_UUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@| Z֩5UVPUI5֗jkVj֡P꺪Mj֯I!jZIZZj֤֤֚U/֪PjZUI!jZRPUT5Ԛ_UZT(C¥T*UTZjRkM UT*RJRPI H$ $I"$HDB$DDDI$ $I H$"DDHD!DI$I$IDDDDDDI$I$DDDDDDI$I$IDDDDDDI$I$DDDDDDI$WWfW #"? ~binding site for residue po4 a 258ac5@B 1vbinding site for residue po4 a 261ac81vbinding site for residue po4 a 262ac91binding site for residue 5gp a 266bc4{}*1~binding site for residue suc a 268bc6), 1ubinding site for residue mg a 273cc2~1~binding site for residue po4 b 259ac635 1vbinding site for residue po4 b 263bc1 1binding site for residue 5gp b 267bc5mp*1~binding site for residue gol b 269bc7) 1ubinding site for residue mg b 272cc1qs1vbinding site for residue po4 b 274cc3}}1~binding site for residue po4 c 254ac1+- 1vbinding site for residue po4 c 255ac2hj1~binding site for residue suc c 271bc9 1~binding site for residue po4 d 256ac3+- 1vbinding site for residue po4 d 257ac4hj1vbinding site for residue suc d 270bc8 1?333333?333333?333333???????@???0K; @Xhypoxanthine phosphoribosyltransferase; chain: a, b, c, d; ec: 2.4.2.8; engineered: yes3KB83kb8 P 1 21 1BXHB9Bx??,?abcd??? AAAAHHHHHHMHHHHHMHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWFaaG fffff fffff fffff ffffffff ff fffffffff fffff ffffffff fffUf fffffffffffffff  bbxfffUffffff fffff ffffffff fff fffffffff fffff ffffffff ffffffffffffffffffffff fffccr;ff fffff fffBfffff ff fffffffff fffff ffffffff ffffffffffffffffffffff f7]D9aGddrff fffff fffBfffff, ffff fffffffff fffff ffffffff ffffffffffffffffffffff aapo4s  aapo42s aapo43s aapo44s os] [delaa5gp X5gpguanosine-5'-monophosphateaasucXsucsucroseaamg'|bbpo4s bbpo42s bbpo43s bb5gp X5gpguanosine-5'-monophosphatebbgol Xgol glycerolbbmg'|bbpo44s ccpo4s ccpo42s |$ccsuc.~ z xXsucsucroseddpo4s from triddpo42s  8 ddpo43s Is>ddsuc.~Xsucsucroseawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80cwccwc2cwc3cwc4cwc5cwc6cwc7cwc8cwc9cwc10cwc11cwc12cwc13cwc14cwc15cwc16cwc17cwc18cwc19cwc20cwc21cwc22cwc23cwc24cwc25cwc26cwc27cwc28cwc29cwc30cwc31cwc32cwc33cwc34cwc35cwc36cwc37cwc38cwc39cwc40cwc41cwc42cwc43cwc44cwc45cwc46dwddwd2dwd3dwd4dwd5dwd6dwd7dwd8dwd9dwd10dwd11dwd12dwd13dwd14dwd15dwd16dwd17dwd18dwd19dwd20dwd21dwd22dwd23dwd24dwd25dwd26dwd27dwd28dwd29dwd30dwd31dwd32dwd33dwd34dwd35dwd36dwd37dwd38dwd39dwd40dwd41dwd42dwd43dwd44 _met       _his  Ehis $ !"# #!"% Ehis %$&(.%'&%)(*+),)-*-+,/ Ehis &/.028/10/3245363747569 Ehis 098:<B9;:9=<>?=@=A>A?@C Ehis :CBDFLCEDCGFHIGJGKHKIJM _ser DMLNPRMONMQPS _ser NSRTVXSUTSWVY _glyTYXZ\Y[Z] _val Z]\^`]_^]ab``d _glydcegdfeh Ethrehgiknhjihlmkko Eglu ionprwoqposrtsuvttx Easnpxwy{xzyx|{}~|| Eleuy Etyr  _phe  _gln  _ser  _asn _ala  _met Gmet Gasn Ggln  Gasp Bile _glu  Elys   Eval  _leu        Bile      _ser   Hglu # !"  $ Hglu $#%',$&%$(')(*+))- Hgln %-,.05-/.-102134226 Hile.6579=6876:;9<9:> Hgln 7>=?AF>@?>BACBDECCG Hglu ?GFHJOGIHGKJLKMNLLP Hlys HPOQSXPRQPTSUTVUWVY HvalQYXZ\_Y[ZY]^\\` HleuZ`_acg`ba`dcefddh Hglu ahgikphjihlkmlnommq Hleuiqprtxqsrqutvwuuy Hglyryxz|y{z} Hala z}|~}~} Hile~ Hile Hala  Hglu  Hasp _tyr   _lys ! _asn" _thr# _val$ _pro% Eleu& Eala ' Eile( Egly) Eval* _leu+ _lys    , _gly      - _ala  . Hmet/ Hpro!" ! #0 Hphe #"$&-#%$#'&()'*'+(,),*+.1 Hmet$.-/15.0/.21324362 Hala /6579:6876;3 Hasp7;:<>B;=<;?>@A??C4 Hleu<CBDFJCEDCGFHIGGK5 HleuDKJLNRKMLKONPQOOS6 Glys LSRTV[SUTSWVXWYXZY\7 Garg T\[]_f\^]\`_a`bacbdeccg8 _thr]gfhjmgihgkljjn9 _asphnmoqunponrqstrrv: _throvuwy|vxwvz{yy}; _tyr w}|~}~}< _leu~= Eglu > Emet? Easp@ Ephe A EmetB Bala C EvalD Eser E Eser F _tyr G _glyH Hhis I Hser J HthrK HvalL Hser  M Hthr          N _gly O _glu P Eval #!"  $Q Elys $#%',$&%$(')(*)+*-R Eile%-,.04-/.-1203015S _leu.5468<576598:;99=T Blys 6=<>@E=?>=A@BACBDCFU _asp>FEGIMFHGFJIKLJJNV _leuGNMOQUNPONRQSTRRVW _aspOVUWY]VXWVZY[\ZZ^X _thrW^]_ad^`_^bcaaeY _ser _edfhjegfeihkZ _valfkjlnqkmlkopnnr[ _glu lrqsuzrtsrvuwvxyww{\ _glys{z|~{}|] _arg |~^ Easp_ Eile` Eleua Eileb Evalc Eglu d _aspe Eilef Eileg _asph _ser i _glyj Hleuk Hthrl Hleum Hser n Htyr         o Hleu    p Hvalq Hasp# !"  $r Hleu$#%'+$&%$(')*((,s Hphe %,+-/6,.-,0/1203041525347t Hlys -768:?7987;:<;=<>=@u Htyr 8@?ACK@BA@DCEFDGDHEIFIGHJILv _arg ALKMOVLNMLPOQPRQSRTUSSWw _lys MWVXZ_WYXW[Z\[]\^]`x _ala X`_acd`ba`ey _lys aedfhmegfeihjikjlknz Eser fnmoqsnponrqt{ Evalotsuwztvutxyww{| Elys u{z|~{}|{~} Eile|~ Eval Ethr _leu Eleu Easp _lys  Gpro Gthr Ggly _arg  _lys  _val _asp _leu _lys  _ala  _asp         Etyr   Eval ! _gly! 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Hmet/ Hpro0 Hphe           1 Hmet 2 Hala  3 Hasp !#' "! $#%&$$(4 Hleu!(')+/(*)(,+-.,,05 Hleu)0/137021043564486 Hlys 1879;@8:98<;=<>=?>A7 Garg 9A@BDKACBAEDFEGFHGIJHHL8 _thrBLKMORLNMLPQOOS9 _aspMSRTVZSUTSWVXYWW[: _thrT[Z\^a[]\[_`^^b; _tyr \bacembdcbfeghfifjgkhkijlkn< _leucnmoqunponrqstrrv= Eglu ovuwy~vxwvzy{z|}{{> Emetw~? Easp@ Ephe A EmetB Bala C EvalD Eser E Eser F _tyr G _glyH _his I Hser J HthrK HvalL Hser M HthrN _glyO _glu    P Eval              Q Elys          R Eile                S _leu      !          "T Blys   " ! # % * " $ # " & % ' & ( ' ) ( +U _asp # + * , . 2 + - , + / . 0 1 / / 3V _leu , 3 2 4 6 : 3 5 4 3 7 6 8 9 7 7 ;W _asp 4 ; : < > B ; = < ; ? > @ A ? ? 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A @ B A C B Ex _ala = E D F H I E G F E Jy _lys  F J I K M R J L K J N M O N P O Q P Sz Eser K S R T V X S U T S W V Y{ Eval T Y X Z \ _ Y [ Z Y ] ^ \ \ `| Elys  Z ` _ a c h ` b a ` d c e d f e g f i} Eile a i h j l p i k j i m n l o l m q~ Eval j q p r t w q s r q u v t t x Ethr r x w y { ~ x z y x | } { {  _leu y  ~     Eleu   Easp   _lys    Gpro   Gthr   Ggly   _arg    _lys    _val   _asp   _leu   _lys    _ala   _asp   Etyr    Eval         _gly        Ephe                  Ethr               _val      "     !   # _pro  # ( " $ & ) # % $ # ' & ( " ' * _his  $ * ) + - 3 * , + * . - / 0 . 1 . 2 / 2 0 1 4 _glu  + 4 3 5 7 < 4 6 5 4 8 7 9 8 : ; 9 9 = _phe  5 = < > @ G = ? > = A @ B C A D A E B F C F D E H _val > H G I K N H J I H L M K K O Bval I O N P R U O Q P O S T R R V Bgly P V U W Y V X W Z _tyr  W Z Y [ ] e Z \ [ Z ^ ] _ ` ^ a ^ b _ c ` c a b d c f _gly [ f e g i f h g j Bleu g j i k m q j l k j n m o p n n r _asp k r q s u y r t s r v u w x v v z Btyr  s z y { } z | { z ~ }  ~ ~    _lys  {   _glu    Bgln    _tyr    _arg    _asn   _leu   _pro   _tyr    Bval   Egly   Eval   Bleu   _lys    Gpro         Gser           Gval         _tyr                            _ser     ! #    " ! $ _asn   $ # % ' $ & + % $ ( ' ) * ( ( % - _ala - , . 0 1 - / . - 2 _met . 2 1 3 5 9 2 4 3 2 6 5 7 6 8 7 : Gmet 3 : 9 ; = A : < ; : > = ? > @ ? 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C# _val = C B D F I C E D C G H F F J$ _pro D J O I K M P J L K J N M O I N Q% Eleu K Q P R T X Q S R Q U T V W U U Y& Eala R Y X Z \ ] Y [ Z Y ^' Eile Z ^ ] _ a e ^ ` _ ^ b c a d a b f( Egly _ f e g i f h g j) Eval g j i k m p j l k j n o m m q* _leu k q p r t x q s r q u t v w u u y+ _lys  r y x z | y { z y } | ~ }  ~  , _gly z  - _ala  . Hmet  / Hpro  0 Hphe   1 Hmet  2 Hala  3 Hasp  4 Hleu  5 Hleu  6 Hlys   7 _arg   8 _thr  9 _asp  : _thr  ; _tyr    < _leu          = Eglu  > Emet !? Easp! "$(!#"!%$&'%%)@ Ephe ")(*,3)+*)-,./-0-1.2/2014A Emet*4357;46548798:9<B Bala 5<;=?@<>=<AC Eval=A@BDGACBAEFDDHD Eser BHGIKMHJIHLKNE Eser INMOQSNPONRQTF _tyr OTSUW_TVUTXWYZX[X\Y]Z][\^]`G _glyU`_ac`badH Hhis adcegmdfedhgijhkhliljknI Hser enmoqsnponrqtJ Hthrotsuwztvutxyww{K Hvalu{z|~{}|{~~L Hser |M HthrN _glyO _glu P EvalQ Elys R EileS _leuT Blys U _aspV _leuW _aspX _thrY _ser Z _val[ _glu \ _gly] _arg  ^ Easp           _ Eile ` Eleu !a Eile! 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"$(!#"!%$&'%%) Easp")(*,0)+*)-,./--1 _lys *10249132154657687: Gpro2:?9;=@:<;:>=?9>A Gthr;A@BDGACBAEFDDH GglyBHGIKHJIL _arg ILKMOVLNMLPOQPRQSRTUSSW _lys MWVXZ_WYXW[Z\[]\^]` _valX`_acf`ba`deccg _aspagfhjngihgkjlmkko _leuhonprvoqposrtussw _lys pwvxzwyxw{z|{}|~} _ala x _asp Etyr  Eval _gly Ephe  Ethr _val _pro _his  _glu  _phe  _val Bval Bgly _tyr  _gly Bleu     _asp       Btyr    _lys  !#( "! $#%$&%'&) _glu !)(*,1)+*)-,.-/0..2 Bgln *2135:243265768977; _tyr 3;:<>F;=<;?>@A?B?C@DADBCEDG _arg <GFHJQGIHGKJLKMLNMOPNNR _asnHRQSUYRTSRVUWXVVZ _leuSZY[]aZ\[Z^]_`^^b _pro[bgacehbdcbfegafi _tyr cihjltikjimlnompmqnrorpqsru Bvaljutvx{uwvuyzxx| Eglyv|{}|~} Eval} Bleu _lys  Gpro Gser  Gval Gtyr  _ser  _ala  _met Gmet Gasn Ggln  Gasp Bile _glu  Elys   Eval        _leu      Bile  _ser  "! #  Hglu #"$&+#%$#'&(')*((, Hglu $,+-/4,.-,0/1023115 Hgln -5468=576598:9;<::> Hile6>=?AE>@?>BCADABF Hgln ?FEGINFHGFJIKJLMKKO Hglu GONPRWOQPOSRTSUVTTX Hlys PXWY[`XZYX\[]\^]_^a HvalYa`bdgacbaefddh Hleubhgikohjihlkmnllp Hglu ipoqsxprqptsutvwuuy Hleuqyxz|y{zy}|~}} Hglyz Hala  Hile Hile Hala  Hglu  Hasp _tyr   _lys ! _asn" _thr# _val$ _pro% Eleu& Eala ' Eile( Egly) Eval* _leu  + _lys          , _gly - _ala . Hmet # $+!+" %&#'$(%)&*'(,/ Hpro ,1+-/2,.-,0/1+030 Hphe -3246=354376897:7;8<9<:;>1 Hmet4>=?AE>@?>BACBDCF2 Hala ?FEGIJFHGFK3 HaspGKJLNRKMLKONPQOOS4 HleuLSRTVZSUTSWVXYWW[5 HleuT[Z\^b[]\[_^`a__c6 Hlys \cbdfkcedcgfhgihjil7 Garg dlkmovlnmlpoqprqsrtussw8 _thrmwvxz}wyxw{|zz~9 _aspx~}~~: _thr; _tyr < _leu= Eglu$> Emet? Easp@ Ephe A EmetB Bala C EvalD Eser E Eser F _tyr G GglyH Ghis I Gser        J Hthr  K HvalL Hser ! 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