bce3.6-1h/data/swissprot/ 3KWO.pdbdupa 1JI4.pdbB[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Putative Bacterioferritin From Campylobacter Jejuni[/h3] [p]Y.Kim, M.Gu, L.Papazisi, W.Anderson, A.Joachimiak[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3KWO" target="blank"]3KWO[/a] [small](deposited on 01-DEC-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [p][!--icmscript name="42" display slide=slideshow.slides index="Ligand binding site 37" --] [a name="42" href="#_"]Ligand binding site 37[/a] [/p] [p][!--icmscript name="43" display slide=slideshow.slides index="Ligand binding site 38" --] [a name="43" href="#_"]Ligand binding site 38[/a] [/p] [p][!--icmscript name="44" display slide=slideshow.slides index="Ligand binding site 39" --] [a name="44" href="#_"]Ligand binding site 39[/a] [/p] [p][!--icmscript name="45" display slide=slideshow.slides index="Ligand binding site 40" --] [a name="45" href="#_"]Ligand binding site 40[/a] [/p] [p][!--icmscript name="46" display slide=slideshow.slides index="Ligand binding site 41" --] [a name="46" href="#_"]Ligand binding site 41[/a] [/p] [p][!--icmscript name="47" display slide=slideshow.slides index="Ligand binding site 42" --] [a name="47" href="#_"]Ligand binding site 42[/a] [/p] [p][!--icmscript name="48" display slide=slideshow.slides index="Ligand binding site 43" --] [a name="48" href="#_"]Ligand binding site 43[/a] [/p] [p][!--icmscript name="49" display slide=slideshow.slides index="Ligand binding site 44" --] [a name="49" href="#_"]Ligand binding site 44[/a] [/p] [p][!--icmscript name="50" display slide=slideshow.slides index="Ligand binding site 45" --] [a name="50" href="#_"]Ligand binding site 45[/a] [/p] [p][!--icmscript name="51" display slide=slideshow.slides index="Ligand binding site 46" --] [a name="51" href="#_"]Ligand binding site 46[/a] [/p] [p][!--icmscript name="52" display slide=slideshow.slides index="Ligand binding site 47" --] [a name="52" href="#_"]Ligand binding site 47[/a] [/p] [p][!--icmscript name="53" display slide=slideshow.slides index="Ligand binding site 48" --] [a name="53" href="#_"]Ligand binding site 48[/a] [/p] [p][!--icmscript name="54" display slide=slideshow.slides index="Ligand binding site 49" --] [a name="54" href="#_"]Ligand binding site 49[/a] [/p] [p][!--icmscript name="55" display slide=slideshow.slides index="Ligand binding site 50" --] [a name="55" href="#_"]Ligand binding site 50[/a] [/p] [p][!--icmscript name="56" display slide=slideshow.slides index="Ligand binding site 51" --] [a name="56" href="#_"]Ligand binding site 51[/a] [/p] [p][!--icmscript name="57" display slide=slideshow.slides index="Ligand binding site 52" --] [a name="57" href="#_"]Ligand binding site 52[/a] [/p] [p][!--icmscript name="58" display slide=slideshow.slides index="Ligand binding site 53" --] [a name="58" href="#_"]Ligand binding site 53[/a] [/p] [p][!--icmscript name="59" display slide=slideshow.slides index="Ligand binding site 54" --] [a name="59" href="#_"]Ligand binding site 54[/a] [/p] [p][!--icmscript name="60" display slide=slideshow.slides index="Ligand binding site 55" --] [a name="60" href="#_"]Ligand binding site 55[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1JI4.pdb3KWO a_3KWOB1  1JI43csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] 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oT@:O]90`i3b+%/wr]e]Z\5aa>}OFtSIEb^dhjSry"Y;|p\\c)R%B[9Ç)Muhm(C\f8'FvMTj6`ԶO2 2E=1Q<#7N<=":Hfy &=nZu]y?ݟ{[rF0DjijjO}v%lF~~&=Q=<~0-X %q YB9O{C#AAfݺu#/o@Cb*< ~O|Nb J\T/N$uGMl2pQ#gdCP|IĿea9;^,o>dj͵}3mG\)6iش5Aڲ8/ ^F!:GC1:zSa1)mq^ 3f +Wxۛ"GF^vBAjYC( mvmNdsT!D= |W }Amc$[#z"!4W:~seKp ;71Atf.;p9S6mg%6 !?f[{=QtJFrY#넙B@ *1c]J{ ^'Oa"TttZ})ݢ6/D2|S): Ѻ y$m|} f9-ޮSqd- אaoHhs6"@,`\>Kb]`vi T5qr딠z ±WAy&a\p>"wTh,y(&ap" {1HqE\~2eۺ[tBuV6|KZYدnC!>Dz⇲+Hwf=dle\$,m>s_xĜa PSt,#^)""®mu2mKmEQ3fdLs'wT)׏ϥ/fryJm>M}I8%   k<<p?gRIENDB`move=1000;blend=1000;3KWOB1f AI A jU֪_WZkW֫_jUUֿ_U_WjZU_jZZkUkUVUk_VW֪֪UֵU֯Z WZU_j_֫Z֪WU֫ZUUUU_jUU_jUjUUUUZUUZ_ZZU֫Zֿ֪֫WZj * ֫_jUUֿZjUZ֪_WZkWUWUW֪WU֫WWVVUkUVUkUjjWZkZZZ_j**I?n  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWOE0z Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$! ]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine 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b#tQh42|r'C;K;Fc#|xD""d\mL'$C$ٹkX/.>áE*)W!O"re#+LEmE&h,׈bHIRrK!1WpFN_?x8c\ؾ} e=‰j=B$'ohnrr%**ի?$!aAJ0^k&@SU $56laj==Ud(<c] #־KJ IDAT;3_ 23g=tu}FNΏLJ*ՠtRQUδiGx_df~^m&7@WqOt(Z-ｷOO{p݉\>bcriq8Zhzq8:HO.TLO'5?"66g$/--Nw}V#e6_f _S4|4ǎpyl.QKjD$Xe̜˦M- 66 0ߦ5T1.O=u={.`d哸|y#wʔL:W݅HJ3(ө_8j?P[fjW:]`o*acժ2 J|qC\2X2 W|p>l $'/ I8UUKN|| E8/A0'I^$1q*Ug+*+%KH4sJ)/bqU֯ɓlh4י1I/C+={7F.\x8(9gܝ7ɘ1O\\1JeI䦦bo -e ŋ]Ӊye,^x9s8q<==v#?O^ |K\T\40Խf޽8hƇ:CQO_Ǧ,׭b4c/mؤ268̪SY*fϮd7)=Gٌh$5kp`t:7npj{;W'Z#Yÿ7FMOΞJaz}zt:--T Z-0qߋ`L~0O|FWo/fiLOANZ{l==>x{Mahv[+XI}=U*\χ=ox}m /plz߱ln{7w7wrޫm7 ?:yR.e4 ?=mN mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO$0  z Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$! /  Ĕi/Jҵ%)<1hMsE%"@ǢMg5Őky(Fe (r0.$ǖJQDr)=5 jszVaZ.8 s 54ָ繊kA YL@ǤYo8< Yd ,Z',9$D@i HhrQZ1O5R9(cZ9c^P\8i%9q3%Gk -楮kǵb <"/{V<"[@1@ `PP`\Ӕc8ᤘ(4(,rR^䰱CA@T xAO5jio`YȬ楄8֤[ {ދޕYX1C(8H= hT K0E#ZGBj)KkP(Ŗ5x8[֞?Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 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S>OxI2sD(㄀:B xސسƞDv(ۊ4irnAʋ/q:X#Ei4~U}烷Zt.OQXm}DIDATg~%JM[C<½I,̙ǐ$d2v՗?Q*4rhTRo7ǻu#KR թs|O 4?^B?^ų}/}}sgf_<7>;xoų}/}}sgf_<7>;xoų}/}}sgf_<7>;xoų}JIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO909$* I$I$I$I$I$I$I$I$I $I$II$I$I$I$I$*z P!   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ЂlA2J}@5 #[6$`lm‚v LfBQlJhrPX(씔r90r7 "hȤl'prT2*Mcj mW(DP˝/닛@lI۬|g2mt/]E͓,Zn:v */fIGp^31ȗ``PsS$'cj0(S߮7 ضpRN==ΑCr5P~, ]ї:`Qc#rFJNN+p~ 6\Ɂp"`LwXɨ+[Uڪpv[9M'-jbFkzis1ˍ\Zcuh B;ws721WQ<8~TvvWki6UUTR!"d1& ( =$)7Z# U΁IބDC@0A[UV]Oͭ7u]]Ů2dKT6WYLE1[k#$aprԪ ;XnJ-39OLŚ٨#+-n֮Q.w2Rmʤ[y@gT0 }˃i2,t '($bs FP\=@- "FFQrϹcU:\scQ[at.]:YZYp&{c9zW1҃AH-Huo)cwrr]H*ѭ½~^fb*65vP3[J!5mSmtf":;k "i-f?XBʪlM0T;Q`+cbh`jyÇp8yyÇp8yyÇp&&&&&&&&<8p<<8yp1111111yÇp8y11111yÇp8yyÇpyy8LLLLLM /  Ĕi/Jҵ%)<1hMsE%"@ǢMg5Őky(Fe (r0.$ǖJQDr)=5 jszVaZ.8 s 54ָ繊kA YL@ǤYo8< Yd ,Z',9$D@i HhrQZ1O5R9(cZ9c^P\8i%9q3%Gk -楮kǵb <"/{V<"[@1@ `PP`\Ӕc8ᤘ(4(,rR^䰱CA@T xAO5jio`YȬ楄8֤[ {ދޕYX1C(8H= hT K0E#ZGBj)KkP(Ŗ5x8[֞?Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ι$=?]@1 @?'a?'a? y??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition%PNG  IHDRc IDATxwTǿNߥ,,ՊD#I4FD|nb|%1F(jDcA b*XbnSyx-g],3s3sBfV=kabP0dԦ:TP_󹏲;Ҝ1ԚT0@GfX>m pQ1^~4b;FF&@jĈ^B*d!Dד_G,k2wRI݅ؓN{dx X,tȣJsjMA;DFL856kρ@?X6<z51B.1 Xż,tBfY%e*ũn?@)4kD.sFm|@x phv(-ۃQ?2%f b g2_Tl}q1@7t\xXH!Mj9gs9jM 9V $*ioYwt%M,{oX[CV^kcEh S7l;4h浗b:38o#LQu)Ϋ7֢(O?ny0-9KAşk1;{HZZCoʶ&yaNuvM@q"YH F,.Qۺj(n+P/v=rС06b{EਤjBBN3>za)`0'pu' Ӏ_f|͵*I(7,Lyrdst/0c\qLf ђi|ls .F|v]0 FAnp-sσONzۑvNf[@~w91peZ:S, ![~\ÆQM70೐N܎q:8nͦh$kgf1{zs-r癝_ FGg~XE+TI&_ƞJVy?hpUGIp$L0-qUW7iLVAAd |l&>V \ϺgAAZ&APw(]I$,.TdL`ȫtdu[IvGQ hp8x<5>Hp_-'An$?%wg<O~ A5+6=_@Av&Cy\/eW(]b.FJ]nkDᛑ86xy@l^xsɇM(hs'UuHD,\Ӱ- 5-?} ZyN#fO%c_[ƙp\@%_]LKK DHa\6O. NnH)03vwoE/[Aq15"=&rb5Hx%4 bKr)!Nb%%#0o}"'%3DtW0VvCUXBOWgm&~KĮ!;<!ƦXme&{ mW瓲]/HnhEe0He0HC$BIS=VYJ?QX5 Z$*e  HJCrR4B%x틁&xQ롊rb\XZo#^%G,?=G.UHl~P ֐Jh$VGe}vV"U̼d=1SĪہ*a8n~}T TbQ6!ҳD~vN'nG|< !D9y@+QT1X ` HntQ#9dǁ ~TE^p?înI"wVd6La".I 3FĊE3]Cz ~O4F -m1愻 6gq1AMxUİAf޵fw ڌ$O)@IID.5?lKVې؅$nJdUv2jĈc‹Xyэ eizr`~c50__5 p6 16Á[cϻ.vsi:CB-HHL&㽂|/IBQ10"wɉ(cu.e0}Jג\,|9p @wB <^W98۱9\.^)<`9rn_Bv%xw`We=iΝ(DzU|DP[AT#HߌXRTŪlPwPx\w(Bj'];scávF=SF2ZT}:8O;Fmy|ohRﱩœ)?F H>xxx&^4~ݯ X2Z"ivp;ضnc!{0|pRHlI96#J]mׁXvA]]s",a,ov0JniHRDTJce#6 ˁc`S&wנ:Rg4 LHݱGDbŇ%Z< yڕy y)fpB}FN}"ާRZZh׏dCf] cr;cJq/H㝭e#.%^'2/]x$\3f).9b@Kl#7;" ao&o殜gzIDǖ?FLt xkn"V^rI%G ߚ~xoo8GR?G'TTb14„btBDu~YK@<~9:jW>6_ӱc 'E\ە ^IS >,p;0s,GX1u~$"=.xa*jDZH7$4kQP@#7zńoID >JiZL"!ph6}<)1ia!Y0 q p*hL0:r ک ^6Ev$X]M!f&Gi\OLt׀>NgquT:ZVQ7Y.IDAT%c}wriݪgڄ#~+K#%`uP+F.`:}N<) ^OSj"$l"XzH ?($S煽N$pblC/:i>D>W ,}"޲xQ NȃTCZ"~͎P+V.rG4BgWôȓ.=,h ^t8qB>~n'md++a<&rrj[hE4jUШf :6^!pA !#$BX'WsbPYӏO&P+}Fbrt,Eq7ΐoD:x8 l 4he7G-l:RRЈy۩$,Y\_14 hCgqZ7ҡxDeL3k7g[؄3լȓnx6`BT,ҵd;}K@yyD<ih6a`D"D=dȺ0nk[u3b Z:ۃ)qvm-F$0 '1>0N1Q KdhGd 1]ʐ/HY8x}]BA_ϺHMcH7=$O6X(Yh7lN7]f1 ]Ty* $!^NlA}B +leX9#'\ ֟ o+EH04mٲ䂱4i8v&B)jG<)'.FW4UJnrRPJug8Rs rgⶈJL$O~8 ';~(c*lt~W﹑}=1!|:+9L*ݛV"=y %䮇QkE DUZ!FyWD#H露^ƛw>4"!dy=&f+ҵu`g'|ġy/by|>  :Qie q U0XWBvy, l!gX䱐3,Xy, <rE 9"aBΰc!gX䱐3,XY wvu?lIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWOI60z P!   CCc nTTDPP9 ;SEϼk]m\~Rƃ.'%3i[kJMtH*u!`9utYQ5UV?*a5MnM%h8Fk̊"n&S(37[z*`cM۵fvS#s[qI+ZX8IuwK{l6vr.|^,܃- |&઎e]l&ةyITrQo Ptr:TDNJII7j-R 63RN6tė[f,˹XL9|&74?Pͪ\km%AuSRmjQlKQ[s+/[KZF=^+,|HB1+:&Ar&sʆ1ԃC1WalRDV1.4*97G9  A"CeBK.e=cjDZFҊ&tʃA8Dd9!Ĝr# ahB;*)ل%s7*2^OJ/M Jruэ){2Pfd{)S'$3-([1US;vJ*k[[ra[n+ZkmNmTcs\ ݱJΔC7iee76U:A,cr a\I2fM\6~ks2L%j2+YQX3-mMF8W\jb"Z\˻D\€7 k9p3ۗ9X| MuOsG/^흻i d1>T7 CaYl) , ERhJmMz ݺ?^7^ \:5/(m6Ʃ.#A' ~m1۪~Үܾ15s/t+Q)171ʥd\˝ۛM5IUAВVTjn\[IhQ[Yls]w0N՜kM3h$Mη:tJ,jvk'kw+n`*UYRF Xde׬q*ZI]GZ?0x RơX5tt֤HIVq \< xLM6جliخyK~↮c;ndW;zJ ؝;*:ܤ͝Xx9Hc0sgf ]Ji5@*2$d2`z*2aRVX&/TPE`ّp))*j⡳h "JclxV .9 )c& B3XqSì-9*f>/Lqf=R  L0(] }AS:H8w5Dվ@醐n`kwg24fL,DJ=32bmP" w lU]CAo{qUrrYf/"BuѠѩ6$Ԫl b* mn(Q+U24Dz zE=Ynkquݷ"4naq{snܼk+l[zAF5yK B@0ڜ5-jkRmL]PsUc c3VdV5ޫ'R}qɶ9`C7 mf6LnP8EB2Ad), HX`Q0j9ʽTQх^Q7 3nBe2qX:*d+ ;n%n.96u^͢1Y][صzaC5%#y0pVk..#u+^j*i5$VQ,B/mʪd$,bG_qIE΄! ȹ4͖Dln=؝ 6>  `f(tat2PTP՚ȶì @uP8Df4Ҩ4  V5 44!(!%[wwzmSh)qlYVk2u!*uQ27i6^j}Lb0Q3 +iݦIMDPqPD2A[y±8``c`ʁjl5EM@alRXшT! ЂlA2J}@5 #[6$`lm‚v LfBQlJhrPX(씔r90r7 "hȤl'prT2*Mcj mW(DP˝/닛@lI۬|g2mt/]E͓,Zn:v */fIGp^31ȗ``PsS$'cj0(S߮7 ضpRN==ΑCr5P~, ]ї:`Qc#rFJNN+p~ 6\Ɂp"`LwXɨ+[Uڪpv[9M'-jbFkzis1ˍ\Zcuh B;ws721WQ<8~TvvWki6UUTR!"d1& ( =$)7Z# U΁IބDC@0A[UV]Oͭ7u]]Ů2dKT6WYLE1[k#$aprԪ ;XnJ-39OLŚ٨#+-n֮Q.w2Rmʤ[y@gT0 }˃i2,t '($bs FP\=@- "FFQrϹcU:\scQ[at.]:YZYp&{c9zW1҃AH-Huo)cwrr]H*ѭ½~^fb*65vP3[J!5mSmtf":;k "i-f?XBʪlM0T;Q`+cbh`jyÇp8yyÇp8yyÇp&&&&&&&&<8p<<8yp1111111yÇp8y11111yÇp8yyÇpyy8LLLLLM   44mmmmmmmmmmmmmmmmmmm c5M uBZԓPsIAMJ"ǩa$G&Id u 088\¢B@T0Ս T@H95&$iQe &GHJLA҅e@p E@bL4p@) !%8%$АAkARDT@Q ( 8*X`\. X8 \Hi8'JVXeEA0xì%G:$PŚbbH &IX@Ր9"L䇩H1#Aԏmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j 9 WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@??+1JI4AfffL?p}#+3KWOAfff333?p};?$??p?@@_@?y"Em@ ^rfrfrfrfrfrfrfrfrfrfrfή@ÒQTP䟾ܮ_=X|˵<_Rn?)/0!4bh:_M5`=͉W|bL+J,!fFQGpw{?8w<" ''!S@"KZXV@ˊSp#lk FN<΢95z쇡{J, 4iFOQ8?Xǎ}!B̉'X4> )44,$13B$E,a0Hp4@0#bņӖ7}b3[8˗p`8jk8 r-O./⡇'  Fش@gWSɉ'EfŸqׯ//O?Mpn))\#bD,pZ8~<5=@=y: @㺏G9ݡvIx?ΪU8s0arKJm]fܒpni(H -n)aiŌ65&GĆ -+ >l<^x\xu<@*06Muu^νE@>tݜ/L@.LsRKyZ֭z0p=i3dB$*J) BJq6!4;~7'l2jkkO:y~=uHa`t(/@) lx<]'bYn  43?)c坊+NQa)y=uC J:dx"Zc8ܾQiOe!4 ͲiYiM”r"LH Jnv~d<9J^(,m*\²LL+澎´ٙ9I'4;ƌe"BvD.޴e,{7ߌ/ƀ>g1 1I,f1}b1;֏p"rHiY*ݔH,Eye%W|gO?q|`9g}6-^0Nhk _(' DNpKGϦLw}4Zko|̟?C;om ?׃-h,?PG # #v]Kv:'Cu_(eI롓$j:xKF}neb"V_<ݜu, x 6qF-[ƤI\~ӧ3k,|>WK/W_e֭)e^ޱ1 8]lK4ׅ ]_xoJhF ƍ㮻bٲeL<ѣG3uT9wKs} !U6' >)_t)<GfժU,h{?=],̾V4!_Jڠ` 6E,wmp4 7-tR`-+/5߿ c?p~ݻٹs'#G<{NSnGvP۪>VӋA85b"q387нx=ܵ앂-^%PJ5Hi"ő=;)uG^}SOQPP~3V^wX  Q|衇_U*G8=ѨoݓızjoRc~۔txDl0JC=CϸS ,dc͖ɆopCn _;^zѣGٵk+!a|` M;:mY=?:bxF =Ždx/^L(_Κ5+i BP?Fbp 3f`,neT`e-ӊe=OgSupށ78z(&Mb͚5Y7| w&'ٶpNE8`m޼LK P+?0esgz}% ZڵkY2»'^sFY;`~'^ƅ^F1RCMspEXm57dԩk&[3fz:)++4M̙ܹs:{뷽ѦrX+1:0g &pYgӓv)TNW_ͷv]'Jf@xr>zslc p 0\Ӹ!Eӏ$'v0zhF1 Gy׼;d}O0zh***5frrյt&Y;UJl߾ͻF^̂&13TF^r "mk:Gv&s<]p3 jmΉKG# 0[ЦMsF^z~?7tS'p,E9[0g_IDR iI׳1 yG-_KJ}}=#Fh1ǙȚuϧQ;{0t0<yҒx zPVZn*+\`M;|~I#$tu#ǫB 'ǀaxu#a*НY42pסbz-Rv*귉lY 4-af&7L8QF1p@~0rȹh0-Bh|VK\? =Tc6:uÇejkkлg9=0OLKHe"-f~#9pdg%EfѯcGLG`|t5wߵY/[|HLJ\q^'څϝк--Ogmq\]IWqYCiEp4`$#^[%ktJ)=Zlw^S2c؉DP؟,+)x/8Htv7ػd{lcQ(&u)?oFGkCJ7gpW]عΫߎ`ʸ+"ie/ 8vIU$>9iT{Suh3CϦ3wݗ]C,ir !2d ]^V SαEsX<ɉur8P|4xBIɸ3l{ke ôb42^~YL[_øbK2!dCfu !2cHlokW97fO/m/'MMZ⳨SךiT4l1(q=. f^ҺYu^7J#5ԱJ8xdjUY[vMZCK ߋi@)g?Sw3#]BV'3I !L%3p@!dxD* %-,^& i`3]+xEw0+ɄRڿP(;ƨi!J鲓>*v%rkc3}µN83a:Gl5{gVe-$}o˙:;3usݎJ~VIG]?Sv_ψI9T&:yn',ǜ^mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUUUUꪪI I$UUURI*OUUUUUUUUUUUUUUUUUUUUUUPQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj ֩?ITj ZA@JRj ZA֠T jTI֠?TO֠// Rj֩?ZA֠A֠j@֪j֟ RjZjA@kTA֠"H"$"H"$"H$!@"$"H$DD!B$"H"!DI$DDI$DDI$!B WWW#UUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@??? $??@^2t;:^@?i?i?i??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 22PNG  IHDRc IDATxy`TwdIÖ" QWPQ\jkպj.jZkk[tsiEUQQE@vaIBwmf2$w=ܙs>#\c2SsZ>C]C%*Kvקf1h8z"9#ÁfC$|.^noU3]i)YlTՇp{ꩮ?FE!6/or5O=E$9Xv,6!Hl2k`$?׃DšLǯxq{ipPXIuQvjx7$I I!TI"9) ,S"Y,XR½^]`O)оAwb'q{{hSӲ5 !׋-)tt RUQ%Bk?[_Ξb_K͟ ᰖFiֈksXm6|V+>ݎin^/χ=9>?ĥ)zr230R: ODK.tbw:X, $udp}=~׋Un{V0bDrr9A,YՃ΀5Ɗ׋͆jkUyL$t]G64D͍zeJx4EUSB tUQP}>l2J:~w]]}/]K+:k<̴iFzXx6-]ʙ_蚆ihbw89. @n7ڨ!X> z3tO4i~?tUESUIIX,`;oc#4KwdѢ9bD9q%vShlIIAucmȚ7஻L/C} q]x;$XvT%K5tSD-<*Dłi>~,<=w=Ӄ#<==Ӄ#<==Ӄ#<==Ӄ#<==Ӄg۸ꂇz=^V Ye $#I2BHUb̥MFj6^Mm}o?]gќIK 4ME/ ].tI2_2$cX,6K$Տ?ku G`ltdBuQJ6x: W~;GU㧦Sx}.~~Շn !L-dAedيjfc&a9$lVW@^cR?ΆOp&+w~5Lڅϡj~ՏHFw-Z\:![0?oBs gR*ΤT9H;I'sg\ѓL8GR ~Kye Ŏ-ҭawUQ:IzI~8Tv^~dBFJə83[⟀Auq`t_XwwƄ^(\&LJ%ř 59]H0ltKX[ !Di6T=_ngyl+_5[ d rtsDFeIzrE*6#]=n)]^?n[Xuɥk!g"V,Y66uȒbC,di Bh|pϵ/7ӐqNk;VCSFoJPT? Xunwa:s ]C1ze  iɽe+~Z٣q)jeOKEVzoQ`*ĆҴw[5:w]\$C_-`bVKPpP5Euk;w.gR2:% 0Bһ?~ð[8BIY/jtSϛ -iO?;]Сe!Ie5-!0dsk J˶2bd|^uV\o͖-ǒwfP ЌIW#lZCaج$J1Wh 8dg vFQgjEؿ?Æ K裏RPPo_|EZ&P8q>f`2ߧ7' glMfM"=%X`ne.&O̡CÆ%c]{L48鿳WDiVVmy.xv1gsal tS_0cS75`e6V b=x7/Wx7ׯ_\L h-{W;zy;=v7f BBǧx*n$ll,dds.Lx=い:FaG}Daa!wsGNMZ VTՏ_yy⦛XWY BDT#XUYAB'މ|> >ŋǽx"gϣj_sWK/ki]蓟(E3syu<6sۼyPTEEoF Z,Y]v%x!aQ r-x&>V\O?n<?|m=%Ár5bi(=9OF4P1 gb&1躎ܵk_g"`d@wkkkL:nI;y+s']h'1|OU&qxw\=C`Wvۇ$%އsUqg\=x" @^hr[Xݻ7x#GiynJYzui/ձpB6nlr:pyq{M!ihݱG=Xrq#\Ƈ-X#EWя7 Y|G3o>D"ae[ϛF$y晦O<?ggEQXfM>}8xp899Y Crh3V'\ɍ~k5]&\Z*4+ٹ\TY|lTW'Ϻuq8lNglxK~gٲeL286>4٩ Uf7;Vv|OD-<7]|4!݋[ 8{%,1IF`z /3t5|^,1-+9иj2B^~2-9|2}k2 <͗缎HhA+ɦ³S\޺`́Z˹e[Yc)X4Q:w3}ݻ+)L_ڌkJ7ۮ^;5$Ѧ3y814 ?G`hjkqyb37D%<~ŋ_Z|ݺ nFJWiVt]wsc=2[S3f4ڃ9sBѻ6&Ik‚ z-`6#N ,ͧH'jFQB<_~3N5$S9;?F$süt 77E^eҦoD(8v@h`{F4mQ4?di`s`&3D~no=6[RLEySYSfh!1QPD%IRԼhihvJ֬yiӢsжP~^e2#})f2A#;;憜9y!jL_#j006`Gl OAM}p:;j(;/ﾙXS<7۶1~L("9౏VLVTc]sc̒|~7^͘gbOb7VKpSz4` v46qVo?f\cNII轂)7XQHݠ!`L H>݉.4fu}l1yNϖG] b:DF+bE6h0w\lĉ $;wdرM]0Æͪ,,ԧxB&=زE-\}èBt69cy讥ulaUZá UWjO>$foMAF@cc#4L}rwW'(8LyӥOxS4!ipZBthNG*d Lݰeh*՞ 4(t uf7p`轊JQ +]W(/X*R|/zgͨ}fa3(ξÛؾw%5u'ЅmW>~-iƪ]c0mvw%Ы< ˃ZSh%"Q̷^ ŠʱZMhߡ9j*;S $09sdV $W9J?=Ϟ=˗GܾUVEvIdlY35~1}]7 ]C[@5v|'3wy}FdwһD|ŵ'QX%DdQ/._5x*t#5f-O>$/HKKs9'bwxs͉.t'8쩦V Q "#}_i*${h#Ɏ4RdEsەϰd5vӈ֓d3Jn.ւ?ٜxnE˔?x<1|?]rҤI̞=71_3 DOp1ܬA$&4p=h1Ғ3>*<߻P5>dh0'kUЃs o%}=CMOŋv/saٲe{\yl=?Z\q޽f=TMᫍoFi?7LJoGGikќx4(/X60m3DWhMqo;ƓÖbWu髜f,XjG®ҵ,vs獏?U<؃SQ4~g4W'qRնw˗/駟'y']C}W]uUPpũ/{__zů="lUm"-WDބmp@Iw .4+j~+GRS_|e$-b`~./ovCeVz>xQ pB~qF<SwM 5x|?Nu]9&(]DCw )əF#^}4k}…'7sǫQ]w ~@t)]Itu+W "2%-bAQQvb7-9 Y|oga&;F# ELJ%;?CiH§-ESPcЃdm >ǵ#EusZQ-X'h0ejkk hCq'Ls\M$s[*k8|l75dgouJMl(Z{%CJp3{ߠ$hN\Ç䶇~Ei&RUt@yݺ{c59Xʚ2E^H$;p$bԤݕ!t / m3 ;i?ZKPC+]ypr" 3 57VQpTՖsazW5 '8Tz>x.o^ ]212Ӷ$I3j2蘏mǾ)*]dׅG֌3&6^E=Q;$L j4IjOPX[_2jIZB܂`&mձF.b$I"GxQ@0WH5gl>#gD(ߗ$.灇\aC8纵YG딪z `(BӤ5V5h>N4g),И1\',S%:zzP/k0@vz5*EU1zԨǐwTڦ]vTtC/+ x)E52+?tRz- O]S_A$no=cг#Ά$ ' w鬎Ȝ;e[=(jUZf܍,[y@S'o7weQUNwSjNS6ّƨSڤ4Fn^wdpԛuϺMWY-|~X a-!DnąSgsNE#nc9\&Wy |@]]W+^0am8MNJ3 y74;ep1a T) k]@<^!PuZ Vac֔}*w(?:$%X,Vd W -`UMuf X-VdjZ[l$7IDAT6\^z#^.M4 6yj xuIA!w0=] {tp-N65 sSٸ+h&3#`@nIBV5,^~جv85}pyHaҨQjN dDqZkAۉB֑b_N>ǪJ?1 mLdM!pҒ8p(e_RRz s8$Ile^c ~Qb9ESFIl%)iEaٰ;Xvv;II -'~篾~ـ˨q.yǂMBHT֔1nx!sGxTՖS^Yę^#2h ;]L M#$- '95 >EoP53\=bk 0 'W$=JQiP`;'XbGɪwΘ7H|N !Iɕeej_C |~~Sx) z1k ̚r`VK@U1eH,he&!!j*_ozf?"aYXP~|~vSrQvrQrQ؈CUI<- =!c*nZ+1c ,pQU? ǂOhwVmӻP\ S |\3> $ R(>~ۍfbJW(V+OQ)z xCU3@auuoe0k4~F  LCF2|[VL3ኦ>`5y9neг(b4|x IBSU4U [HKSU [v6PS#Ϩ_RW*Lf~qlIfn<kKH;6E>^N]66⪫U[O}=Zuuxp?:dEx 8HKeεF~O~ӠZ$$>aL5#TWMC:.w-q eiؾcñTT$'s B$BFFBFjnS3pixttMQTC1Cކuu?[쫙ovHHx| f10 DN@pS`;E9E48k*)"I25ufڵ3oG3s!^wƙ tFX?^$Iٿ7;HIaBܷł#5/zaV+wv)Hlm$"7 MAW]/FiVogÅ1il&w0z^%7s9HHTtcs+kà-9TD! ?Ҳ(eu1NWz60n9~gpP# ^;ϽRTD%РmdS7 x|Wb\~1 0b|uӚ+B#$-OTmdd`3Y%!s̻ؾo kVŧn iӚ_`w;e O FSR R0Z6ɡeBfZoSpm_Mز t]'=5<W=5LL)޿Cl㪦 KrG+K !B0];z.249/peeϳzuZ9RȺihGE?MSOy"va"M4G ;MO\pەϘ'k$=5ۯ[w͛4ʺvЅΑ7TEd ET] Ʃ|b$!s 1i ߿u} !z{7 ےZa&aB6t+mn /Faxa`t^Uv;NƱ(`I '< Mhb*>A θGeUD>GckW + +O#E &E$#,G cMo3ӆMEAuL9@w>̉SW2ㅐ:|lr ЅqnN_7BB |W ,A+0<( eü>#0<$L"Lfk?BdWsԘ$ )H<*-dDZ$>k)ѿwq=Fɺc((`7 a:@]`F{~Dc,;6U0V$!!IM)dZ||w""S<$ٓAߜ<[5tM5ծ\4hԃh@qnɡ:AYM0.Xb=q?BB MD:>U1i޽6aY$I.7{[|3t꺣MotrkH Xnvze`kc0zhm?uc,hAhDT<$ Q} 5M5ܬa2,SYS; Ҵ8cm^c@ $I2|^S+ED6z Fۖu@H5j #[~9Wnw}>b&imbe[Qzi>D` M$Jr[< ̺k0"1-(rGN5WzH *Ў.e)$P:Mo dAU<Dj$gMM7ł f#[A[Nf]C*CNj{8leԐZ%t$dz`EqԚfuٙ}蓝GEH?WF5󠾣HufH#ɞLmC%ESbڡJ+T]OzN/:>Y5I5(䐘g̣AYcxj"% IQSKjr&%v06*(-J~F&9!#(t㇟u e V5VFDk0 ]g\Mm =uHl"Y臢zSt2 f=@3זJdkm}8Ғgxۂ@\Rx9>QUW43\W߾e\)^ކt O^ItCŜ1z6, ,[Y䩸{B'3-h əoVǴ+0gmȘU]E4MEI x.hwgi]6mĵ802ZޥOOkht]Lּ'k_5։B7Ӟt4l|5 D <RʘۚZ h@ه+,N|An ]oFC,[ ?Z@XѦf塙\Oh#Be7__n@lOwAgP7Ҳ(ل&R}elUxrA323G >^4%L !6`<>ŃSOǫiga$[ƿڥl?fO~IENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO!#0 ꪯUUUUU_UUUUUUUUUU$IUUUUUUU$J$UUUUUUUUURI'UUUUEUUUUUUUUUUUUUQUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj JT% Rj֩?%* )U A֠P*'֩?jA@P_PRAA֡(UOR'ZR J ZZ֩ UkUV֡(UORkU ZP_5BA?A@"$"H"$"H"$H 0 1$DDI"Daa"$"H`DI$DDI$DDI$0 0 WfWW#UUUUJUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUI*?Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??1t`@?L,?L,?L,??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3%PNG  IHDRc IDATxw]}?[WQE$Q$:H&&F Wp3,?``DZgLlE1 $fԦܙsi{?9Qhk瞲>w_ذUW`;^]]gHι(A2is-o_+ebY!g?{ &g~D OigjRl߻2mA DJɻ;^!jaiZax_ѣa|"D g{]y'N-^է?K/5"{gu8핕<1; #8d 9=^WDNB29l޹f( BDǼWs;E&Lp| o\L'Ř2aN|\a.VJI x}ήV'RFjcҔQJk߻qBce=KK!aR0M&D)Sgou+xWԔ?@*cV| 8f ! 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LDSGDTnzƻQ0C;B@"oo g0hc<33>c<33>c<33>c<33>c<33>c<33o~O? Z&c ר0ty9v2i r'nj$JJHRw]_zyж 06te"A:N&u'ۦvT>oqכ1>8w]JIZ<4Aeq>b\r,XL' Gyi`R"AiRe$”B>oq3ʑHA@iY:C#]t ()IqrDQ}m=L* Ik>Oj qr'QQaZJ霨I^)-"1Ki:?80 Z}_M%%2py4wՙ8yF;")Գ0 Iev(\r'DHhmmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUW $I%UUUTJ$UUUUUUUUUTPQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj R? IT I֠?/j ZP5OR'ZրP_P?֩?Z֠֠P*IOZP_hZZ֩ZZP*IMjOR@ZKր"$"H"$"H"$H!DDI$D""HB!DI$DB"$"H"$""$! WW#UUUUUUUUUT*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUxIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???*"$??@ߏ33a@?@EA?@EA?@EA??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4!PNG  IHDRc IDATxy]U?{ޚ+IUHBBb6ب ЧhJPnZ}TڲZhhCLlP (!! ;a[CֽU&n> |px?U8%V<㚞h9eB8D}ZBkF1cI $~VAk47n=j?tҥ1u۸'n|P,FHB+R8QSzӘ>e>BHֈܳZh4SgB+1Zu8bF=6wTt<B(9|8d͚p헏[#H!bNx!(Hk hA9FX:Fy.6R845Wn@epjVZ;s)"3Iy,hkDRJZ`5kNm|Zn7&ʸHLA@_03A g2P38нkLBJƩr@_tY{kxMSJĮ8Rfu,6}B'zNHXqDL8b1SETܠP#h4"B+p+RyWu=;{47N1T Xw6+R Y9Lȵ.04k K4d2v]2j]6>k0LFW !ɒqjEI.lE֓Zk6F) R[ZNiKkM{kZkuZA_0M VhR%NCoVB%$Wo Ge5&x&IPH^q<M{s^cV% bB猅 Z h'Ѐxehb)Z4 )$xtj} fC4%弹qʘ۟0gvBcA1B3]>k y5}Ccnw)<֬1b4f[#tZXV L,>i5U4Ŭ'9I)K'Z'y2ԗE2auVV"qCEV{YTD H)`7>I#uOV6MiS?RCUtxo$H\5eꮙLaATXz>M/=R cl?hrފUS,D$B&LI/Z*Ehmo5':m]4M[WU fYulgܷ!qXw%k^K7CM]6]qF9R᤾.8*#*Ir biYyFa,7Z_/8l쨺9e2^bJHE(q`^r*LgһmsUuU+d" P,㰩\5ɳ`2?x-)}s3CtN8'#yOyzϦ/!Q,Ǐ'"3*I."Vkh5-ccXƓXS=~:!$Jq^rOxHdQtLsYtc^eԀ]Cݻ9ܻeb:1)^߳%mS֎"5 #mYix0*THuh f2e]a u4~aD lkmee560($mVU27ݷJO~6ekec5X_Z:cGs ho+KqUү|YKBLSLiр{?_ڦO'؈e;k*6\eDqO~N8 ǬךYOG&C[&Cc6t]!HC|ϧ?MJ>#]qh}<<\G:^&ԹsoNHl[|]]bb:mZD:'gUf>|v)D8BJ\_mc3ҥ@:Ee}> k'%qh9b;!k!qWBAckkiE$%:( Jњ!hٞ eK'qȶp-MMr*(kMN]RdRxqtq@_lߣ2B Y!IIHIF&!?ØWs7Zb̘zRb>u>^]A@T,u ,!q" DAJ C];KDah[( b,єRd<<EZPHm0]JkRǡE0D)ehH8<ϐ'n`XCtE ahEa Nx' |uq/G+Ai`8Z ۶ʹYF)e!-Rk) @6cKJg{\p5[Y˥+' ȸA0<ھ"C~^y)R'LGk(PVVeӝGH8ӻ o|go8plO.®ҤOX~򽽩r+6R%,Qd*#O"]OcF+EP ?tX T_&9KN*婿>aHˑof]6= /5ﺋC@C_ű`%\ g>mQ(vFJK(p]7UxQF X(sL85#/!Azzp}3F׮%R8vdH_gC8EzXk}czUYZOs'ϙڠ^ʆf?hOAzdJ {ϩk֘-ĴABqv_8Y[`P(xPNZ,ȕy*WM@͛DGGc۶ښEk+Νy.wJI38QQu=S׬)-McrW)LZB2ov}q{ǁo.=qC!mۏ;~kG]] xY^SNe|g(bo\?gm$Y^Ti$1(3}q{)(rtZl1Rf2ॗػ!wqޕ#$㘠PoDӁeOqX &γhJlAX J+>{q̎;3o sׯW^uiM, 634wL%ЈvByO5\{LLZ|_e…|&\鏒dطo/[2]{A< IC&~K/x6A|80o.ݒy~oT <>RJVZŪU{ظq#wf,Ib]<|e:ibJzޟn# <z8q4BPAv*|_|5:tC]z5,^G}nN/rAT7M;~\O֙)8!!ggv'juis]m䂴 =x_bRJ .ii4e,_k_}>m|]C[ʲw,<{5 mmdL" xn|l]=:x)Hкr& ֙3p}7O1 *BiSE<"fR"E䣈B]o5տ0In)?MCC={hkD)E.?o~~_1-v9w/aȜF1yEO?͚ۙ. )d2y x$q:> |dt)yvn2O$[Ic$D[53YLr }=/ZT[aq 'cD숡 utZ)ܲs8փ/P{BQD` 04 NǕH& jZaHɣF.MYFlFqؿw/kׯ|WGit AqvmœNAi UZk"KS&Еϣ☶V6:Ī6IzX>Ni ' A.gWlHLhCZ  Iɫ6o݆/tEݰU臵rgԧaqᅧ3sf+/f#ίUy i'~ZmgsK1p6F<'Rks<㴑Šzam YSQ)җFՎeAYUus ,:7]4OFS[[Jgϓqu| lO5|9Vb[]*K/c|Yl/}-kVb_Ft><^8Q'τY^0u[[ɶ74e2ʢq" \#2Πb+U:PyFgGZ;:Le9̵iyD@(y"R m3fԶ%v`cDSA4v)Lҳh AF>GIR!_}[öZ؁WʋTuTٟI$ٓfdtxG'ɼ x o:M#Nĩ>}2dU[Y,mi>tJݕu"8eŊR0$ 4nHǡCF8Ai ߹#,#Xѵz<ٳ|y8LRZ'sRZ A!CqLwHw(E|27l06bpT5x%O H+= q"K"6!8Z#6ʱ-;ПLmJ+Ò 4M m}jS $PP(%O8džmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 U_ꪪA$I$UUURI*OUUUUUUUUUTQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW?zCCC Cj R? ITj ZAZ֠P_Z'R/hUj/j j kTZOրP_/P_/Zj5ZkTZ֪ZP_ P_/h"H"$"H"$"DB"H"$"D$!B"$"H!DDI$DDIDDIB WW#UUUUUUUUUT(UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU?Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??x2t;x^@?°?°?°??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 58PNG  IHDRc IDATxw`3[B"!:Doj $v\7_KB;\8v 6齃@ j̼3[W"zE3{f[y9 hG;€?ӎѮ<ӎani7\8I$W>x$2?a+MB\ 8r9wޡk>$$`Feyl ݎKت_?g$v$qPa/$?qOR׮%%fC2}ݻ73iiq1PsUcfbj* YuΗWu󥗐e ipJ嚆lOWz;!`PofNHH(UU4MSQT^]FEu1Gs;!tLO'CbHMJbHJ q11::)9{LiTw;"}׾*J*Kp*xx.< MSQUgv5٠%* ۍnlbZZxNdYFs:8xn,Vk v9;ҫ1=)8LUu NlQWu5JL $؄BQx8Bjs]̝;_E#r0)8ڭoEA˅łl2!4 UQ8raX0hƱꊊ y+"&g;Zs$@z./!uDGcZ$ QyV˪U{2o_"*s;CJzsۼ!4UTK(,|#K$0(sd".&d R^uņ˱3;"gDYcHɗ[o0<DY%AIy>Վ J* ((D~C9L᪤^đS[1lF[ NGu_Y {. Wq(gs[ԝ$Yljñ;ʙ5.Voz>1)ov}ȾcZ&!Kf$IFVEt뛂v4Bei&H?Ӳ!p>L1eL\LLcum-SSRѺ9{* IN슄L+.&? k8yns4{=2]Tm,]zmcBՃl#3 ;s{/:I`^AҥsQUAؼxYe!bw '7~Q`s[p’\o+. meÆbͩKT^7d>megc9SIzQ57I֩V<QO(_>ΙŕW䡇> :*4x/}}_Шc43=R҈%I.-1Ȳ d7`E$p9<8F$IXӧvZF;vxŭSiЅl~#=}?%#3=l&>Q̲}4t@ĸRck"Sz _]J)?^JUu NUSrm!6O?ΙS0&0tlԨ%rywD\tHQD8ͺo6h> o faxWW(j*δi!{_|q+q^r3f̘6UDk=gNz}{k,zk.]*~_vm"Y?nWy{l(\'3=[`oI9穧?OLۃ?bjCNW(ϋӧ65?Ofz6SF^7Wr/Z3gΐΊ+^6n5& MXQ$! 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OMi*iYh 8{d2hf ;}_)XdȲnhV{Bp8˩.+ GY8**T5ͷVÐĸNt/hԑ v^63P} j<^EZL=p?~zG .=ټwU\cT`HdB`QBJ}ǎEeQQDaZúu<6TqƧFt87ALt6knB܅_8邃͉ݜ<݇1rx%X!DtUSp{OȒLiAYe!./ms$ĥPXBiEGNmcHDcu; pyxv6y =!#LMv㨨QY?5de$Ӂ dt;p񪞀7bM:WUۿ#C;d?:f>d߮')3}{]$R8ɻp|c%[5>aú1vh;Dnn1yc(4UEx8?uJq)fd&6&Q'y qUܺVWe/@TP/dPcg(,IoԝC_STM%)o\B3ӳzʽ;uփ;~ɲekyU=9j@NJC >1LSMrR>u+#Q3L-{Vi 7ώ̗⫝PQ5o-sQy$JRPRϜI0sܳiŀPGg;c'oVh`kWY#ztmsrO*$$lFMIfTS9JT­sO~t PiiX_#/hBp"oG\bĠ+{Hp0s#CabB65⫻X,&|2J띶:uHg$x^-Qh$$n;iPӐ,8~zgXB\=Gt&4+5ld$OY(Sz0':DS]:iSXr+&9>\kYIzW=qv^Q:uH[mÁz,mPW6}ֲ҇fs !su5ƕcoiu,rW (kLn3BS1O߾Њ{` [Pa/srPb#Y&Cm {~]~'\>ҝϒ]*nTM$Mj/$@_ ǯ?(.,(d{4;mWڡ=€~h"8~&3?%5Gs-EQnsdĹYx̸5QCy*bl IV7s$Q^UDR|HJ(Ϡށ(✠MW=F"8 #h rNOinznƣ\(|ˉ;$N}ڄWg5&dY-6*H/V&S',(^/eCPUN刐 Μ@QiQA'(H@~{PD*-Zq7,-]($))dXW *F&ʎ@x]ܻl}LLb"($.\ɪ[jLY[Ҋ@ck]=#Q7-JsGA(Ȓ~S>cc6Y1`Inkv [kYw>q::kYA/:#o\Q.f<$ $XkMK_Ni9> = (.7ƔB`=xCUegpVpF(:ĺ-uRH#,/QQptP>SSy)'z5;k*NIg0>xY9ۘ8nqx`ffCBrPo}:$%TCCYN>!>,4=Aҕg}.0(mP7"ܦ&wQtv|ǎך(@5?II,IFM{W"!1&kvx O)#hѬj%'y*$tU${0 k&Yn^(?ۇ!dCqJdQjV"^l1տ(CWz!}'W/>dF=Igx%\}RR hPLô %J(1C0XZYcԅI&<4t_coETNk렢*OpN0}8b[UUW=ƑS[pjx @uH:dX,!V~U7su-}RIAU []m'7xS5zwdYD)L*/b`23"K&^'ծJNIfhQ(1@;EEٌSm.,LF%REjH)W<ʯj)ؖ$IW%щ(J]kQs|}L?5.]#)U= ?E_o^Սj.Q'"9blrbw%8**Jғ&L}< fNB'֩)KO69w.DSqOuDzgIihBeeQ,,cfc2U&E) #M[ "܍;T#TKPr }ogmɇj3"g#oإc/u?>F$ѷA;Uф[<ɉM zO]=YCq{݆rܾt 9: "1LlEdsll,#\1JBk. 57^cÑg_vEg1ТsrB׀Y\@=;sD45ƇH(\ U(>IDA~{|~j# \hEey5ƨݖlV ]P4^TUA3@ԚUSU]ʸ!sٲkJKDP\,F,b&SCIy}}m7xV78z"91f]_&e!eȁWm!X<(>B!C7^[܏/&]AqP CQ5rO~8Iy,(^'dqKBBH bt۱B+6Tsj.[ku?_[BPY]_4T0J+y1uԍ =I;1F%KXy\j$$㗭k͕?ݜiHf蕖EJb*Sך:'鮪kV"57U#I_k'8kqy2U apvBEMu>.>BmY6v/ APa mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO*#0 ꪪꪪUUUUUUUUUUUUUUUUTI%UUUUUUTI*UUUUUUUUUUI$UUUUEUUUUUUUUUUUUUUAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVzCCC Cj JT% PIOZP_?RJU֠/jZ'R/hj ֪O֠//% IOZP_%)BR J ZZ֩ UkUV֡(UORkU ZP_5BA?A@"$"H"$"H"$H 0 1$DDI"Daa"$"H`DI$DDI$DDI$0 0 WWfW#UUUUJIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUa?Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???yq$??=࣐2^@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6M4PNG  IHDRc IDATxw|TeϙJ%{HQ"t^ŕ]ޫW];k_Q"-@JH9sd&$dB/^C&gyw&yԂ& ڒb[ӶuGl~Baظ1ϡc?Ɩ"-<Æu!>ŷ66Ii4LQ3h:.8Whژ]D3G \~s0~ĺjd\د:1)K΋hUiCiߖv;~8lN'B9ûmEZw[0[^2.N ˅3&֩?EUЋh~3yMFLB>K#IEݎbu F]h>3ytL4͏W[B\Ubķnmy/N>|8^4MSvz)xT]U5χpͧSɢ" 4 ǃiі" LS^ιH)B͆b!5 ]s-E4DLqzUED<;aw!.FaF HSZʀqq8p{[U`Y|s5 7u\t bfGH)av\Sm0gl6]}&ϩع ae4T٪~x:wn͊x B'bK|۠SR8x07a+\7{s1gaǦ(9#ȯzq WIekז\S ́_)S.Hb$?n'6M75z?tX3ɽ8u;2En^ H%s͚}S߇WTiƯC @yRRRgțlv_9^96?|(Wr͚,^>&0Rz3k-$7/} k8zrOkg~ˆAJtU ,@Ú@#HJh[J|HȚ2_(d!㉔ξPUլ{}nHt.atUZZRٓFujctN-#)}ʞh em*P+qZWwyϿy#a-..KMq`ٰ)vl6vbO8Ryz~s$asHA+!'7|=Ęq.Фb>BpDE@~a.q$'vhR`hS{AƊ@Ua5[>WH#I[Vq薐q3҆emA޸he=dMzSԹ+R(++CJPs BH T8`KSiE֝/jh3O0; !2&uB}Y? 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EMNg؁d::Ap Bp>Y, N~>MH ukbIIO}k m{WY 7[i~f+!wn0E%yu((a_y9N'H;(*f63ۍF/h- R +(W8LRE.$Hݘi' 2pĮ\.0 _ ;? rFyU~<%%֌*χp8 %-/Y+` L{=bfOd)];#h;UBlFfn_o;'vh 0 B>:Uy/B -Ͳ%$cuŜ;y^cVh( UjHCJ08ÅCpaʐRbEhjeXJ$Py6_;s=ß@4|n7~M~ee8bc\(6œyʋYoe$@vdtb|3kA xK AE];! ;OJ07}4ۚXMf%F*0aÞdV>+!iﱛ6]ݔ;GWlS m7ЅFBRb{a3ZExwt5C?vNxMUFN锒aiZB#|TsJ/ڶHp8btu4eХΜI B׷ZF5ط70cnjwzPgKJ 4gǃ%{6+mTL,#%+i}:$!*$`CQ+JI]MT+=r_{Oo|M Fn^NG Ve81a{ب%ԫ˶lK\3t,na88yd&F6fphZݎZoDJndW}& $f^i#p9c"Jt  x&W&4.IENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO'#0 UWUUU_ꪪI$I$UUURI*OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTPUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj ֩?ITj JPBR%*AZ֠P_JjTI֠/Z_֩?Z֠֠ JBRZV?ITj A%*/P_/ZjUVUkOjZ&POZ/Z_"H"$"H"$"D 0 a"$"H$DD 0 I$DD0 1$DDI$DDDDC 0 WWfW#UUUUUUUUUUUUUUUUUJIUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??(`@C`@?`B?`B?`B??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7 PNG  IHDRc IDATxyeoU:dM-$, $@C =\"sTPx@eS@VN ٓzztO2tO@}tMOMSݿ~]y ( \L P0x &O@ (@<'`L P0x &O@ (@<'`L P0x &O@ (@<'`L P0x &O@ (@<'`L P0x &O@ (@<'`L 7r[D0.2֯/N<䀖f@`Ær[E+gK/ugS#з9 <ՎXsK/X2N9;`ww EKXp!cw…jjb( Y]H&Y#}erK=Y;>婟 CF E"0Z(P՜R'r>]@C4 LSGIs Q"\dp?֒CeCxH,èb hۘN/fO{viyJ<ϾH(N8Ų-lĖ6mYڼo}nwXq{Gtu#FljVTFQaTM#S`$L4Y${3p)B߀O9=n,*T5ivDJ 2l b&mbq~=)B IJmT)@ AHH6$E! q'8yNx>{Wס*F6MFO532$li lIJ{΄3|$UEJ45 ˲h! T*6Y!]I u Xph~p\.l2^adTm%혖ܶ͞[{m۲M+EQBBeg!͒6MG=]gXۖvFύ7GӀ ~.dSxfaU45qaUQ_ih#!3Rrœ9|ϘOÓNbܪUؖeAӺu=:aD"Gl\QÃwo?#&ߧ si6Xή}KgsVR6t#pk@<䇆I7o^ ނs<^{56@"It#DR[=XfRO~·mÜ9sH$lܸ˗dt/=xG x-kd:x_^3o𧻓!g1-35GUTd '%qm/핗r BPtQ5/Xv-v`ࢋEc#wy}?}N,Mb?Xt-rPM#:b_$]c&٬Mat4ZwLrͻz]QW=f7k@SNL}~3L¢E=A;C0 N',u砓pW^U/N> ׷|{k 6ڷ 6,c!A\~R@Y8#;[x/_oy.:zG<,ĴζebY,m" &[6FDSCNR85-e,i;U𹪫EeM;vkja4Ԏ*VG$%t@AUC(Bq;ȡ'0#s6uP_?o$1F*UB14E(}3E+k hU͉:ۛul[q,Y𻗾};RE+t0qZꪇP[5H8F$CSCFm[u~[xX3~ +^oUev C4X9XSTWSU1ȿmٌhs)NRH䅥>}²~Ego>JuEUD#dp@kI-<6(1a`&: ʵ/-B(M mĖF7$yE%@zb+:l;2 /His+8ܶCiOsn@Y\\yS,@ģRS,< ϼOF[s]XG8oC68q:{sN^DKP{:wUH z;5B4ZAMEh.+R"^gIضͦ텭u$@yeN4zl74T9'/${jn#B3#>5:=ٚBQ^eWIeFD^56pv]Ϯn'o3RJ.;=?"KJO`kj?EIU2z;l ҙT3vH[tPҙvw`²mƍ֫vGD`׾MG$Ga$_3Nd(L˶0-)s)ljVVR3t(U kjJnoQ:\7hq޵o##Nf}Ӽ]$-g:{-"nP Pr7QJ:ݎhZN\Bv~PP'n-KIoصo#;|4~zĶ-w"igIFʇhj8L%N?a|NZ sZnSN  K~n$DXQ*$5X+KT`hH)XӅq/L=d)6zXn1LUB*MԴ4;/+'0`x Dc[fB'T$opfZYٌSOH7RѝsP6&0~LOXJl)Q@\zB(̉t2m۶0L˶ڶݷm+6y5кҭ!4 <>7܄l}~+?ŖG8 XydQi uؽiw>{ZMxK{©KZeYr3r޾}Ԅk8Z6zHiLP e0l88f׍– \0j|d( p {=1S"}# DRƚrNcUcl4,ۤiƍζvz ^}Y__%=mL f.^0j 7 )4 8 Iiۼv׋y{mCqkVJ<˻^@ |<1iiaT% -yfu.eݺ=5pݾ hhENRLκ{6Xm˰25WoxU f-s{':}.[{]J[0 c[NLdAt#W>0:ٺb!3^]vp~ctFu=E4,JV*Rq_޿i7i 3l 've+ֽNp6vmե~$;;#~g*L;h5jtȹwx'CF1fTv)=$>םRhMtt =#Tϸ`sknH!Ѵ?w6ȕb>c[5*qB(KG -mF9(ĿvzF@SUvp̦j(z6EgF"'5<L+N^P$*AJb>]L33H5cZYv] -mL̳\lmejGaǻ0zfY \3T"gZel θ[0NV`_s>b*p=uy #5t2M6踊hjdjKEא҉>2=“ W0;]`l]l޹}_aT G쿞7dݖf_{jB~:6Gs-zBWW5[?b_9:r{FO#$x N"RژȪ& G"B8~UM4{gKzGqO0tFsn>n>zS)*%OHZvC&uya  H^|`!Cz~B8x,+l$!kʦejc׹K>pg^Ǵ s~ymse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 U_UUUUUUUUUUUUI$UUUUUUUI$I%UUUUUUUUUTIUUUUUUUUUUUUUUUUUUUUUAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj ֩?ITj ZA*T*P֠/j@֩?ITj ZA@Zj R֠֠P*IOZP_TրP_/P_/Zj5ZkTZ֪ZP_ P_/h"H"$"H"$"DB!DI$D$H!B "$"H!DDI$DDIDDIB WWpWf#UUUUUUUUUUUUUUUUUUUUUIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUJIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??@@6+_@?@$r?@$r?@$r??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8*PNG  IHDRc IDATxwT?L6.aA* *KDcM%^c71Wo\ck$BL #AEE)K[٩?N>:3== p8$$I2ve@u) 55 n hn;Bs{-H3NGT4]ET*V"K2$!0^h)B4">6{;?M`ܸ$ u]i=r|3?$۟O0 n=đƽ4}kP5MSt(s R5$ۍ4i,'cB4WOs Im&Zi˛=kە|E$2$+jߥ i,8G鄖>%'ZΒS_Bsk-m i`NvxǶ+_Cv"NLD;EnES(+L/MҎ~q3&.qSϛ}!c<Wϴ)3={>cU]E:H`@('VQSʸH ^r%'_FIQ){?b߁]?!zv+\,I D:p>]wz d W<¼q94a?Nm #{LZ!z{vOY{x)OKoU,ʢh{stu4h`yDaރy۳;keHڝ Mˌ ))h2YOHg[猅 }4Ĕ,V@@cߛ)x=Y䖒'˟p"KdIB,5ZtYv]T`P+U]O^=JnpΒ(-% R۸O7$iF(.(Ge:ɐ6@h2. ǟ^wj||l8n 9ffn7)6nEb,?^uJf,8N7h/l~8ӫ.-Ѐ)(jb`q|?ڲşyyC7?̜|Pt@zF9ryWN;a- G:P(qq8tZs' !aq)_0j% M8{'e;˽pBCQ躞D\rȲ]0:z|Ik#BSUmUOpot1D<.t']%OBSH^Z¤H.TDBgǾ7il=LSa YD W~K,3>?x46o{m6v@(yt9k?DT bhj UWдCTvV3MSk2X+Mom@Sḭ>a7ٵ?NxO ՟~0͡i* yjwSr!:KU@ $EaىkS}ouSy4cC͜!^BC_#u/c az!Z7"+4z(#},9.{ƭO"t.#{me!DP1%e]:tsBl_!P.vyMӘ7c {>4s]۴y*Whh3gMM}oS#q sjQӰz:sG:-'+j̘ "1q!n$/PKW2]9(j`sq5 Sr=Jɹ Bq<\*U tH4ȕI'2cbwĔ0J+ސ^2̙v^g0ЄkUo>@GP3P+V;Bt[h 41N=3HL%TNYɋ1qbg?in?Bs" W5aL-lUbB5t]Ôm1%BLG;EQ(˜ezElF3'N,SRXAIa9E)Ϙq捣L@~n)uY<bʯ3x:Xn4&/FG !1g)۶U, ?1)SϓOr/ieaF=:eI% V$ e +Q2f"Ey?ޘk8\" پ獔;Uى$IAs[->oƐ%*wvPh+jo5]W-I(.,|ÙXq5##dv I2n%_@ԓyokTNY7UgU49nBt!%ٰҏvδ䖒iJG5&9B$dY6%Q֖Nr\ZN'.5iNX`}fbJǝ$UU+pö#V%\NƘYd |<`_dy3=*0<ىptp9t[q;FY$?~}@7:8n҉eQ\PΘqT|@L5捪c a>E1V f.GB" ƪkg?6\ x\>`܈D;I$ 8Ҹ_xsk䕡 h4Fw$;!3i܇a44PTCY*O`Mjlg}+5GU:Y<$ 7۴$<5 7OA2f{4&n'ij*~o {Qc!; @$_1,䜛o9ȡ]HCJхnJV#ғ<5yV RO 0:<./~o.9Y捥9Nɡ&TMAhʡ;P۷f.Ҿ_&fCKR@Bؙ4MPGl#p^Qn0o=7kNJSgAb NCr0@/ICSUfL\8$+Ϝu=$EJHJr BGtɳ<YOC"I +ɈC}63;;Y ߽Sb]ZYF%{_#ge̵9 w4"5^ 6k 4l!zP=./=.}tH4,;lmPUy6A0fj Ĕ6--Y`v3 3 R `>"X'A;L- n0bм#+om#^Y6v&qޱc~;`<Q^gK 4/3nKTrdQ7:NBp_:#}~uZutyMif:Dhkk3̋hir.T.$}) %7cʄyD5Vy iK 28Ej+\u&R|+{eڒgܸqM8V1nϧi*B8nT--LNV>e:_ya**㬳}I,Y<]a\T{B5ܓ]f; 9vťKO˲fzA{j}a|l{~c ?VMoXE xr"ރqx`~2qbҾ5Ziؓ4&:))`466rz@ %-S1i %Xw᝶^h( &dyjgBgWx;Ŋ{ǎ;سgWuV\ɋ/|vޠ1-B̀m~FBca{d#qe"zPXRfu?_k8w.ziV]w]f6cUaG$ɳ /pEu}o|#5_wC3_H5Ҕfy&`O O7;әy^k/iN"?pW s｝9s&7oަ'[MY$@Z< mپn'GPz}"%XCA:֭`ݺu\%\?{9_b̘1Cݔ@3|TX$^z@uu5< L4 ̭s8Okgm,ƶ 4~0$Q̖Ve wZ@>\S@#iw&'Os[Dccӏ70k,̙CiilfDYd7|mnOܷ@Gqcɭi=XMT? s)+o-b̙dggC.b&O/K>,6m80iI38SN9˗Dhii5[&W֖Thw{6i3H;kߑ3f .ۍvtde_V=]aVޓظ|[9餓z1{<#_p)aP!!qD8:@e0^@S`e䰵jժ~%8V ?Oy饗>س)ȯ@9qjd]:/oi-9%'gFV^ހ1ㆭ:gy%~j $Iy?aK/ƍyٲe w}wO`f=5jH|{s)n @ $〘9NbpS6h2pe!y򲋘8Y0t~o~$j" 7\䖑]T4EASH8/}@s4dYTdIҙ)c o  أq6(4+]N O|籦Ѳj MIDATH# $hιL;USL]h)yrrrRr;ӆdh0f{0VVMt+zϫqgʕ=B|l0macdyq]h(Jm/c9%%ٴwNƑ'uH +e6~XS?9ӖR;6#Ȧ/8xswspW=B~dذuS]]sMͥ2ŀQ%L4&BDcaӉl#_mR#(23i$^{ԜL{I@;ؐ(sSp}6qm9^b뎿ٮ/+O:s3{ Y%}I2MݵsgϺ&/FG'Dc*aJ]'%(o|̙l߾Ԥ%&^N瞵HR۶}yr0iɼ6k_8*Yv-7l*s9_o9'D"&*7o~&]i؋=KQcDc!}K@xk ѫ}=o[<ĬcvL`g[<ė|?|1ijJ8a(q:m`m'~Vm/K$u{M+ǯ(="%ā $@( Y ]Eq8tt_M7d1f;vMr^q3K}\2A ($嘯>y<..Htx+)}m/~uc"+oʼn8Os.xN'Fqn7~ Yqyߍ&O8Hrz8mH&L-0+" X}$6-5]0dA:cŗði)%O?/0•1#,p9BC2$!V3]v.4,GVIH)^_QUJR l Ǹ0v+1H` $.7jn%KL=UIA@RFRbI+|Fa<}cIKQ5%!+qKҶ^Hctx0%+HP)i XltS;qtc:&U#GOFA?Hnut:w#_-/H5F$2ȼC>麆.4ckV c5In/)JHMg54+j eS!蜧)a.Hs C}~@d@ˈ(y@BC:$$drfYF
mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO"0 UUWUUUWUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWz Cj ֩ T֩?jA@P_RTKZA֠T jTI֠?/ZTAP_P_Z'R/ZZ֩ZZP*IMjOZj րj /ZI$DDI$DDI"D!B"$"H$DD!B$"H"!DI$DDI$DDI$!B W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???3+$??.@@@_@?m?m?m??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9PNG  IHDRcIDATxyp\՝?M,7}y^@I @`J7 MU*ë$*^  L`dcYj~KdْZjuurnw# l#6x<GxHO<i#mOT]>k{HoT#mnzk7=O/y/Kw)z>08+{f1kذa?"bu?kWýK/eːpVSU_/̘1vz㥗<˓oTǀ]uu 4fƏ|C8 A+#.ymyGK#EH'ln1WJ&` h0ÿ-Hɾ:u%%%ny&'NgO 4bjxzP[dinQTtO>y+>_HL䣏3e8F(CJ% P}>H)14C}YYttPvE j=T |$~(- %K%PTGQUUEa Z =v{'l~Κ5(G:MLQi)"T*%Kؿ\7R`ODTFN8̽eϞb1?>FccǕ_r %%~?BQ,kGQ*ZBf\w9;4h[>WH$ts>pzyLAQ n[ڛ(RUTB[8T-tS.򒼬7a* KKXoU[>(TU~$`HI4F4Ȏ|",@+ ؋}Uñ6R"Ӵ|B' Z 6;`mR obyS;_rB`&~{)9a%4A`Ф^hG[4L@(@P-3gpݾ}$ aعOR5s&u{fʭKb - HDڏx/EZQi" GΚ>cۼyl1۷w:^Fn%|S1 EUPTv X,L,&;o+R+# c m® M:ݣ,j]}=z"A7كMW+GHXXz}~;̙\IWC7I9ae#3qDv{ukƖ-[X47SvwlCZK5F!d& x?]ow׭[w7<`eX 9ulZ/e*&)04XPeիy'k{ 7܀i >qQYYIaa!wu'O#[dkD(şhrxbϞ=̚5-ZƍyXl~o/_KPۮ+hm?4 Z̶6v;=[neƍ>|k7nd/G裏xw`8V˾K;nhg [[舴Ж _hcO%%%W_'? ۷og;3uVϡ?wկx\^߸eɃvǤd#BO E舴ie9y]m/m6ڑl۶QFoZv}8}4.__6ns5kB?>|~nv{^K4#$N)< @`3dꫯR]]Mmm-XRڨ7`ݼ[7fjjj^;X`K.eϞ=2~x~HAA$^x pAկZc)U{閣@,#s5Pe(&WsbqwCr_s`~+G]Oַyw_üpHr۪Lq+NզnV*޴psfv$mOlgh {ٳ/`TWW_:RQQkCAk*cҤN,[Gs#<;fDj/ܩҞfʝ.*:YTx? 9WX(p`ik+B(P 3ȤEfskTVTw)O )MK{|ߠ@ϻb (7&CشiS^^NYYo!8 'M^g\NeH)y{kE^gڵhƟ_Gg_@A{~5q:B`}ѕSBannP3C6՟~i֬YٳzXd5+#n)?J 53w&oųeZZZz..Y-'&vDQu?K:xmS;$?Z(reR,/q8yDv!BXz5+WXMvuH,V@.]m5ll5y .~RF H Rxz-enme5d ~=lu_߾>% 5u}Lg>}:ӦMX,E[Aއ &^5@߿rJ@':mk+),,d;pGBeO< S\\ܯsfbUDn~MY<' QTTԯsLI kx]aJOػwo]A7H+Wգ̭>e7]Qc~W;0 jH}fJ9ᖔ|rJ)1LiJ C0B-YVǻ#ku.!Iw$>Շ8U ҝ?'@վ1+fB Ph]6h %~Y:7羱~h5tNՏn4 fL[yP@WORaʔ)gWZ3NXZ MJkכ-o wĂK6bTB(kګ§!L?{nZZZB,[˗^IBiq8ۑ94$clD;L9I&+uܧf{۷̙ĉ_pw$L4=Nct{p=3}e}fM^l]@m_ S2zh.RxYkW| z$`;eiK= tȀxGɋظu!Ŕ)Se/H,84H.,S0r;}f;u''nkx ]z͜5vo`kx:ۧs/S 'Q‚˳V 6oMڿ(fRy6{dzOW,6.jJ4B}K.38xM"J:Ҿ㮀+l5cDUs"4ϴpE㈈."RXko ,ps'r&7hn*T/H#DCy3ٷ MU(Ir;2wfpcJе:I& Ls2̀+ R]^&LcIw.C&0̟vSViM|}.k֥; s x^ /) TܤԖq:<'gE5{|4#:b3,>2^B3cҵvJ"(H$H!^)';3'/!'"n$}iBUTL@Q/L@7-98=KjK lrXH$#L@ף &/vGesaOƯx'\) 0A0a+LR`3{ct<}Ϥs-cZ9dEESE"}43/K*I3}1HVz1T1`.EQ4+*EQ O~6eoئ:*+ "`J %D3=l'VKʙ&b% Pi8 ]QD"qV>d6GӤ.y@2jE]Y(c7@3+B W+:,~$?*Vluv1&`͡)TL)&?0M)MFq.k6 UM#Tl!~5 dkT6bu Z^t..DjQJ8±DdL@*tV:++}燶s#98ysC3 Z+bj.qG(1%"~6w),z\H9SuUlۛF;LZajZkڰc3-sJB8tʫ,֧ƻ_%OOZ 3rIc]䣕8ob:Ә\5-P#3-P_[>i47/uFWn3+Vdzوq%"1M iZՖؾ+TS0yðNBG$Qp'jQBqH$t hmoN8t!.7˕iYEN%$%XK8uFJӊɱoM.+G^|ީhz i(%ĩ#iNԡXRaNUIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUWUUUUUUUUUUUTA%UUUUUUTI*UUUUUUUUUUI$UUUUUUUUUUUUUUUUUUUUUUQQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTzCCC Cj ֩?ITj ZA@JZ@'֩?jA@/ZTAP_P_Z'R/ZAZAkTUZU?Z&P?'Zր֩Z?A@DDI$DDI$D$HB!DI$D$H!BI$DD!B$"H"$"H""HB? WWW#UUUUUUUUUUUUUUUUUUUUUUQTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUOIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??𧶿 Z=a@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10>PNG  IHDRc IDATxwT߷LRtwP0ذ_F4ƨ1Qcb' D]X`;ǽswvwvws}e ty_ xP;$B`Z:ea [H˴4 4Wۮ]H-BJ^I"MU &$e~S9fc£zQdPi3]!K2Bz0  ێ%:5L"HeYX$2QI°,tdBz fо}*ii)W{Sxui$زF_~GQJ" *ȵ-˲0Ӊ% 0@ djݳ-iԜ7,)992\NaI^^_XaT;B- $ Y,gd5b4}v`׮5P=“hz4}_qRDJ*B-=!, Sڲ !(Ȳ)Ig2u= iBBȎG:/ 9aŋeNғa m'pʢV-th! + T, CӈTV6= +0 aY&۶w|B{R=p& "J4#BT Q^QDQYs7u#ò =<ɲ-<1GXiIN{ԄiZc~zQL$ eW1 0gn;К(* ];[ at?pgyNTDZKH"TKyg8[ `78KMaDWI͟z3,!I22r*B%|M,vb`!ӪA=u S#)"Tʄg "+N]@`*ĨWo7z̼ΎNnۛ9#Xt]8+GsYw4Q=DEp)]qO9ϸMJ i4V"Ŷ#׍_Ea"0Hp>͹vY&i_SB!g6iFEhFyyS((mfgN_̒8Z0ebZ&i 71%Ӵ*r6hx%BXH׹_ҮM&yejg: J* (,Σ$XVQ<^?,eWv8XahNI00 XeV6a8|P.\<;Ʊ@-sLJθ%;f2L;}A;QJT9ԖeZr#õ/&yKVM쏲'g6Ω#R)*gךu@[RVQHQi>GK9/ɤb/_,}M+4ZEQ鐕Yg ajtCCҼm|{`'{n4X7lwzwafԶ\0v$IƲL_~oL*ybw}̩#uw3-Qّk3D_ $Iٰ&ϱ UB_@f \`͞uѨ+ !߆ g 0M%ob*($KsLtMEL MS4 n{Q'NgW:_m&Wҍm;餲$ۆ}5p:_nMr8ɘNj̰UpTރutRmxSR X8VYoY7d.c٦e\?IוЍ+<7J ?ۼ)w-akYخ'}f:Ǩɒ0ds7 '}T{ܳ`R|i|餥doùȾ[k ϽeM7#]&Q"xTPL2p ?nhԵΚ|EeM$~UȎ >O*'}LɴmߛZIb!ǻъFOS,f`%8tt7A$ZnD8RۙuU 3!i[e !I2vKX=MϷըyΝt,S,[W8/.Oz'GFYE!a:]Oݶ;Bf#KvYSر w)ujEI).;k&g b%I2^'QU/-ʒi@܅%`:%wƜtp)va2}ܥ<4o]%IY#%aםv%!ۋ7X(4(5]{pS]f0iқض' \I#-0v,wdhNVm{?s?*X!J񂈄%LB`R]Ch(_ގ]n_eA?D6Rك,+Q)cݶwټGSTho# g7#K2AUTˑem{Vc:o~\3,@.pw0d~a6Οq8nDэc<5`Ԯլ$#K0eB<Q} ׏- G;(cMa Sӣ5Lp}P_:>'[9hU~n;-'_~O̜pH%#XU+y/T7MaEnKwS0b58cX≗~7LwBX)ڏ&]2| :UmA)wcˎ4j`:e-(G vv̯91!wRka'a~Kꚧ;=-B K݇' [-8_*USm0ugÎ)'JYh7fNg"УΧ^iD0u셎jۙ1g k>0~Y#QU<0 %'~}5NJr~PZ%Klӱ#k'#\{E3>JG;ag:N<DHj>۴&%<'^?orѩ=p֭T\vs'O=kLi}O<0'OvS~j.jV^Bߜa : oq'7v`㒹΂ ą^(t 6w ˗/?OK#L9^]݇o\)СC?>o{m_2j(J~_$w 7G\7<Ox~E0qD^^EZ|O=rR6oLnCuH.us'i*tÑXN.y,Kt]ŋk=%/ ߿?qk<O/Ux=k;Cdg.^] 6l96l:<>qKF;gܾWt'f=:$+ι'_-o_s'2vX$Ib˖-[:v;8Vsmu+|o)**bN2?!1~ ~@ΌjSi/{P/YKa¡{ҡ/ t9"5{AzYn]RΝ;Çs)..f֝-0An͵DÓO>? #5}iyUzκYVrõDc1Oֿ\-йCՀD~H:xc˖- Ν;Yh%Kpz0ujۓ}kA#EH@}ߒze1M8 }vm *N*v|IRWVՁFcUzj."jkFMQ$ŰrʕUG‘cGs[g##M`9毾INfKv1LA}OIjMj\[`Ѻ=1G \X;d]lQtӮz$ qħuHGAq.?9?KRUW{ZE6M"`̠ `j,I⭡_)I>τ׵;*Cq9s&?O}^M,]￟q9Z'|Rmau3}ܥ=M&K2Kj g\S.,04*DV7>Z[`:dN@v}$ SCok\ MW}ؽ{7Vj7oWF7"h֩eL\u$gS]%Ư?olݵsA8RzRQLv6n="V[d$<IRenmOϟk$96G2]w'gutӧv^UO<8\sMzZkGq߿?;McqJ 3ؓPX¢]FfL]7n]cmkjxA>G v`S;޽;k׮ӫ NM[tԉ g6_~o[7z~Gػ[!Hk +o}TՋږ׾999ѷo_:t@ff&~p8˫ eѨ3:v9sx?t6c /_%\¿]?c=Fnnn5ԫ`F42y?^/Cզ#=FhZ@m?M6/sڵ ڿ`͚}lz_g۶mu]u  Rظs%uU,:n.ZZmYaԉeE gc<zwqjXeΏ;6U$.eYDڴ ^_Xxك8t+u-w@}C)&`0". ĺ0h FM[yK_#i[O#ͻm.â|[vkYvW =H6mw]Ħ/MZ;,a; l_[ho)jT Yy)4lüyHIgOx.K 1уSr 1j(f͚E6m,駟U>u^ԑ \*qDB fY-(; OG V׺Uﲊ /ן9YMxbxg>g>rssK3bYQ-ā#;E|guß^30{Y;uS_?뮛DJHrW@glMéًWVav{f̘ ڹQـM;XLˠ2\B0~٬eBXS 3K #a8Pӎ w:g߬mgm[w\UT^/z r.Źhu*Xf/ke؞}ʹ֮31_zr\$ѻZIDAT~x >#^uΝ Q ~ƍ)ʂ[Sxjxeg#a !j*,a9Y;7)AjI(RN )m p2Wuωu ھb-?O]I'UE(+эH5¼yù ̛WtsϙL2 ][oqܹݱskes| KUCF3l0n@Wq뭷rՉѳt4&*/['LzгOZd1UAiW޷7&i, SKh[gx1LӨiiȒ^Zρ lf-"%ewуIs_՝ӟ۷/sncʔ)dMw7l@@K]SqUg5jְKz1vʭ|TdIf#8tUK(_ FpF gŚ}2kEU%&MG~~KgľddDYj @߾}XlYYYnnM-ZTunjmA%4SpMc;D^X9紟RTv+ιYRܴk%?W( &⛔J$?hQlN?t'4S:m5'zR`|`x š=N?S^.kbwކr~au3hKW>1 {}Fй}/Ɲk= t hAΎg /Lj>27dZ: 4.#wce64*i&~9``tSs*->Pd Y *&Ξr=HH2|v殭5!'LΝ;9[(tj׫SkUз +JW={kevJ<5$9m{?k4Xsm`͖7Jq=p 1g;o#e4=L]ugGs^`HSbڸKzR==NN!,<YBhA,I ^8UU]fd XVV7fh.ԱbM"c ),ǰaø_sMw.s!((%mwzu/sZXBԠ̳3v>U i88s'V% uωaZm;$3m{?ôLTUP,&N- m&X/Z =FnLfZGz͞kzԬYx(qbLÆ s=;v`츑Y\$ICVNZ5*nQ[nlJ\؝p_p7bӷEN=[ Jr9|t/%-vyl _IΉa:uH^ PsoGGsy;vabSNe]>sOk@d,!lg1{,d79q;`毪 KrMد~&(1[xuW]xө]O̡G76?wvuqWs/y{w38w}#Gvm*IA17caDHD2oϱ,9b&8 cO0fLXk<ҭ ]NO0)ih1d^o&Qܪ;\}< Ǽ֏?8 RH d>`k&_z)Y;HOGxdpy9/][krxИ=.iir5c&O0&159UyGqY9|)1$@n9p LZa|EmOm'1M3mMIAze< E P^dE.t0ڝ^6Ms3k vZ "+HLn &M8p`I _| ~e2m_*,%*-}ǎQUExyx<T[ni\VGS~du/5O `sPG# fƈdS'+[?䫷_vC>t"B ǘ4LTʊ-auM$Kius2< BYFeλn^NR33G$t(KQ}Oj\sЮGR22P^MoPvmwK+RX=\yNJUU/Kh"fSc9 RN<{ \BiEXa`haeNUI|BخIǐ!}Jib&#y|W΄p3DPQD07R%71ͫopo^d /ԩ^]; ,ב(8?he%`?NHE`P0HeY\0H8S# J+*= ϣT#% maʳ,|PdT8lۖ6#gir(z=Q@OGFeI!DZ܊Ann.+V`ȑ.aҥK~Y9<e!ݼ#Gg;0EP^ǾeTG"nh2M<~?mD;K6{FΙ#2:u"#;vHŸ?- U*&2n_Gr[Bq:Н'(88 7}bS!+'PM#ƂʍACq#ESOŗ£V ]'ZYɑ={YQ0ig8p Nfs~%o>HW"N @V.2 viV3p c*"$eq(JM2MtMKX}|m^k}ۚbQX;zP&-<1؍yRpHѬk$;ՇLxi۲Al!4º4eUuoE*hB*+ÈFep8Qxo nh֭Kg#or:ބ8 !L衊oMda[:Uu"m$~ZyjXx$Bپ}U Mej-4Zx.[9s d2[x|>ųdIok|:d'o\ JˍGΙS9_J T;}#&Ǚg'бcc}ΦMddgӱwoy$9jo |֍0+}ˊxq)vElmy$ǟyM>̎iӾ=t2ӑ<LY2 hCvqפI8eO_7Ν3رn'sRL"O奥U)^PU5@: @FvMLJFzQ56`ذn=nz?>%;gjK/%49l%%՘kjXkR[힚MhYV1a4<ŤE\('Cz*e.Ip}r~7cF+AbÆTTD9W4,GŭN3Vۅ\M%UmTC/_Me{(!zhĉuȟ ڂ_$-ĜS&4ZXCӪJ jz`QQs\sgeWE[[ۑƶUl`0:DwL@s;p0Ha=lzPHOSs a*j|VHDoyn(.tX9x閝qe Z~'T k?iZߴ*ǵ˖DHE!GROɡCߨ`b׷NW(*~DhʁM i,Ӵa,l7 rF͝KZVߏ(H^CL<Ԗ@'<Ӧq]eZ3;'0臽$";3z4mv%n~~sAOZz=~Y<-FF@NFM.4 2JfM\G8dEG#KaP"XLJFFZc{4SEIL9|bYȦM0|LN $Z;o޽gPv(˅'IThv-eaUâ]G v*|rIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUUUUUUUUU_UU_U_**UUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUPQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWz Cj %!)U J UBRIOZP_?/P_j BRBRZOZj)PPRZV?ITj ZAZAkTZZP*'֩5R/hBA?ZKր$"H"$"H"$"C 0 0đDI$D""Haa$"H"a"H"$"H"""H!a WWfW#UUUUUUUTDUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??`f@4c@?@) ?@) ?@) ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11#PNG  IHDRc IDATxyTչk]SO J j *``5hGsIs1&79ī!Q1A!2 FE0ctCUazky ^kַi @Ɲ<komxOoJ(ŒN ;Ү6 R98R"CEH'Wo=oޘ%RI6l^Ƥbslݹ>v[ðhBC ͼP (RCP(=Bhm5xI"PR:DBQ4=m\HAJǝ頔۲R`9}vi;c8&m M3m.#6ٰy@@ Nr y>^F'iфBh/FIVJIP I!4V?"*xvbMh |*W)ٮ6mjts Q))^Kp0eymdAJGIBضabPO֥=C EA mG7M;h%R MK*"mm%ф!GS!.Ǘ[BnqƉSq:t%--{ {_'ZNJN[Ӗ,=B*M Б`K[ڮXԴ`zId{cor.͛@f-ftR"]a!BF{ @t|]O)yx/ D$tF96ұBCz R jƟiVSn<}Bvt=!%Oߞb^>qH9M&;8v,Vm|MsWfJ7v,V[J1Dٓ'}5b'ua! }F]7;.'\aҎi'vH²-lN5 ]3u]ѵ}{UKB c ɛ  oZ14#WaᴗK"7[`Jjst,۱mwu4s .< !x7Lځ9zWWU680L8E{ ȫΣk:F# b݂ j< &(ʾGg=/q; #m¡0hM342!đJڪмdžsn W QBF!tcgN%G M3лiE;qH?Ymo .(^|Da<6tMgiߌ - KMi_3&cKH!! #YwcӉ{ؼSy#ҧ}'M8@i A) #q)s+th 1`dxQx1[ͼ ]=#Q yhi;#҉rWzfܖ t]7T/ &t~'gd()O=EِwcnDZ}Gx7WYNw ^X N@x6r7>E}a}w9X]!@5.9SlB*++sQvӾ Qn?uշɠC3FF0?lbe5Xǟ@P+e)%Y|x 8хѨgMӈq o7su{.۸=qVqw Jyխ #ski"T=|q\"0/yFz248eꍋ|i+-WMt5xTF"(ҹOLiq $C){/GJځ4wMfibۖp}Ggf@v~ib$b`-I&FE,aS{?8bG^~K#JQUUEաTUUHqJI6za6I!*ZSκ#Y bU!oߑ˱,S@~5Gn.f|r"7vuݦ%QDm.MR r8l낒(&ؿ)bذ>lZqvGL{ KPJaqo%e(PůD Dam>^ݻ[Bt>Fɴೞ௜DZJR[#!()PRe߾J}KFX.]=J+?0X)IuB^zzFԥtA'\Vp(h{v %D<+6 G$yg~ƸKIbE :=P,𲗕8p_:w1#ϼ^e/T6N:!["D{`K۝m,d{]W%_wo^w)B%|7wwhKdRV/sf۱8k_Ys/{0h$<>UzzOρTVj<({R_ ]c`FAG'GIP8VnM' uml)]JpcY{BQUѱ=K!y(Hze*q3,TupupšJ5{Zmg;Ҳ^i>YhCGl@) [zUMy&r$l{ѿд}W@nX?Z)EὭ'͸6m-+()Ѹ; yBջ(a;Vw+G1k[ϮliBxM!&7u:.zGPy̯.D|7PoWμ?MjKe?/xi3>-trS!%gwqx BNJ`YI,;e'0dP쯋Ə`|]R\0ʬ/7cYW3n)>4ӏmpܔ'=ytK wM8.BWI^d{($1/Lcu\0JNZFyzB +fektm(e߼R/ V#'^6~3SL' Bxރu`3J[f#ϵ 7>IJޡ߽ F]k'zq6/cՉ^~-q{>O!4kG(0K2g,R}wk@J{"\T qo "^W/.(5*>q^61;v"lqۓQzxu%sA$ϼ^+-%DD0b1J˹7/Xs׫̙3爇]wulK/HԉׅO[gLl/ HӈK۱rbs@^3{#ZZ#PM) )DÄ"PpO,sUW>{?j(n5~c~;<܌'wr.9kEpN@yvvhv>3+_5Mj5b!DD(uoWros|kX|97p/e w^?̵^3<3fp[u8m[Wu 9?lFצ̸/M3DXv'Z\mYؖ!%@ 1B8Q@Ž:. },]ٳgȑ~U۸z܉'7ɓ{9r$ܹ*={6cǎo;m G92Aק002X_đ3=)l;6MLb'Hs31M㠇B9-|Glذ~K6zҗĞ={\iI%K}{qU{VA3g_[o|w>}^*;!;kZʥ!FJ Y)n'd!,@1MDd8 g ]G ind^2#!d̘1k7Ar%ʕ ʆB@Xvm7=~뗋.u ziy .!@`5f8z6 ={dNKȉھQQ=z0ou|I@u2Ҥ !k3*&YVJm#m+tWb;*8X8zv|x<)1yJo+-B̙39쳩ꫯ9f%.a2DII EEE@vv,t c9Ydt>7BhhII E"P4Qfd}=/c>ln6.`Μ9̚5]I>oÇ;z<3'݀e'=;A)ro,YgܹCQY[~U ))! 1a4XɆj++Yœ1رcD"w_U󉚚M-aPSW5|>[88VeeQz(lɜ<#ƏqQһ72]4A8E1vwm`;&(oaQQX, {$c; l; \r2*jAJ0L8v;ڟ/<<PSA\t>ynt= )% W_͎1 պ>^C"Vjͅ8 & &8Ŵ5r{W/D irwĈ{[}}9]Hk?~|#ΓO>;0k,Fɯ#/ O~~fRc.MLE6TL$K4SW[n%23 0iF8?.mD Ҭbظqy'ϠA2d˖- >/~A}}}'u0Cog@HI;34ocϺ` ^]Ɲ)2&t㐬rŕRHo*;q$Wl>f'$=~N9-j\`ǎ]FL|Fg=tSnݹ>{1yRXu88Ҷq, ;r%E8fCB:a$6Xw?ݠH$NzM7m6xL/+oHO{w`: J$pt%?4'HT GJ̆6bx"ń"s%C8$Io<(yK/gkwmwYFctdL3QB`&UYJlBvL3zoTN8޽ G^n]uJC!]|1׽"N^;dΝ\TVV裏XVm,-/5f$D*E\J:jDF ĉy뭷v駟f̘1߿;wrJƎŋgvuY')zj3ێR*%N? o xR=܈D3g=s 4d~_j ٵkW᤹"~2JJJ]V bc1ׁ nF(DI8Ҵl3_|9Vz5= AO!x tꫯvX7n 0cFk[DBtY}8}Hj!<|H^`}Ŝ`Ҷnbl|Z)n4r<^;#GQY_jIW;֬Yq2dH+Gw<~c[)ͺRT̈́O&{Q vv:rώ: ۷?hƿ|b͚52]抮ܜ0e.= 4-ХeF}BhG+*Ǎ5k0WxhhA>,+|k-O^fiG9O<濪hQQ!{9vE߾};w.7|sm/ǎM]UHI%ZDו2H64tgObjk<<L<]v3|֭[Wʛ2w-Ļ&ac=@D~&BϽrjw69x8 :޽U~5x0glߞo.Z%]9Dm-}瞋1Mkٶ3 [!## }[tHt+t~ ojlW^$ģ;$ׁa={ WcKKֲy>^Vڬ?r'FuɾY^\L @ r P!hFj1* 8J~ Fm\ |0y2x:ViQ/[4b=z0a^f?pIGyn@6fAG7ڐ[:N %F 4IDATPbM#)E4OWـ5_GS dE|uB@XBPĄ Jʂigz;"1 (x[fk/ ضW 9EC"A]"LgK]2I]2iqG3X-8[[u#@݋Cl=~eۿ ޱ,lyS)SSOy<:kS [["L9hyQ'`!+Wn㏷h|קHH9ųq~}+pi"[!,J$²s>)+,PHgݺ&=PFa0X,(FD0"7 V`Ja"^xm-\ҵ]PH'64AmmwjZ06'D*u覟yc~6"- 4Iv7òVv+N:iCh?sjgnAa$Zdgt+8Nk#%ii?MUWOYG yxb֭>}8^)`MV_BSϹ"j-(psnkߖ|bY~ԢibX8f"Q N8*s0)Eo˖ mxUlbQ0q EE!6l!6,wۺC, OGŴU@D<dy 5 ) kS@(Q OY@F<dy 5 ) kS@(Q OY@F<dy 5 ) kS@(Q OY@F<dy 5 ) kS@(Q OY@F<dy 5 ) kS@(Q OY@F<dFIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 U_UWI$A%UUUTJ$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQAEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWgzCCC Cj ֩?ITj ZAZ֠P_J*U$ P?*U'ZրP_P?֩?Z֠֠P*IOZP_hZZ֩ZZP*IMjOR@ZKր"$"H"$"H"$H!B$DDI"D!DI$DB"$"H"$""$! WW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU1Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???wo$??p@I>/f@?]?]?]??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12VPNG  IHDRcIDATxyp՝?ݷ|۲sڱ5qDƛJĵq bfZUV^R9Bc a`_%YhtȒu)ͼ53n}{w @P(.J4go"wtOYYYRqmt)\xt]O; )%BiJ<† N; ʇE-ٳg tt4$H7>^u'aeeeRy#f\'/E+n.G}4hD¿E?u2o<6l͛SJjp92YIGы\I)yW>5wGˆy: RY*u)|:.]:n\it:k{DҊ*'iNxihI)ـM1pe,Bp=p#CK$';&&'9υJ^8ٴi?'tNu ̝!݅мEPi'EIP[[; _Mh )! ER'LFM6w;}$nu4!4&_N*^4k+%tqM̎Dba‘~B}t5Gr&E0OMttti&.r9o/MM`~1Ӓҟ㵸5۽8)+P>:O<{u?غg}vAXC~x*1IϨr0"S($q5 ~ $#pH8(mdrOWIڐ^uG*l;~^y}LU g{7%*Mz}@ڄ[L4v-&xI{ KzqWI49>%ӟ\j\U'7oIď,LDc(Լy}? D׍!U5ϟO[3Tcw xKx}IY'ߏ[h%di#<UקYNTIشi\>%F$v5-}UcdvE8aNYNd1geqګ;_[*˓̡C}tT8sU^ڼvJ<||!5dblMW]K)U5I}'6>:+$<<2i$$p/5soySI<@sb$.'eyFa.w[䟾Pje(Imv6ee膁fH!:8?ш'[g|S*id' !hV0q,I I$<{Il]r{Zd=ܒH̀D VהR41"ǝ*<֢&Bs#W@iRjXuSRQu??஻WO@=crGƚiSp8I)= ?4iĴp j2˩hh X^N3 ``4A)FŰQ.?/ĉ'Xz5w!W~v(y{e>H)9 Zeq3e#@[0"} f0 SnYbXA:ΞGҞ= &&;fL]־q1'2KeRՁvEŭ/P8q#--DJJ()/jJi,+Eљ3ضM,& ̒%K8\ ^Ƙym6N:| Yfא_)IcC) y]Rƫ!O֭J[[o.UU+*`ىiYIy 7UyU\8>lkU>|-KvE??8PhBe紊A$2Ho PYIpζOoC#:ٺu+X;0c1bh!RҴf rlس~e ~ShX49o0_]a``~Bl߾UV8#?zF 7 CbhJoȑ#âU8M,IZIgU>@㊣888qb1zSl0 .Ⱗ|py|f^tQbƟB kyti̜XRϊ+hmm[V\Pphƻo'ğ8 vx&xkmme|K_/l5n>BtU- ,aЄys4{ob<ϰ Z<˖5qٳ'{]?uN6qsm̆ 뮻gZW(JS8czJ<^G:f &n)l]+}=7o&xW_͚5k㡇Z$^#sVL@׭==\zx}񌧟:i:T>pX 0R,3sf%E$b(xW]9y>ոH$D/]nYUW͕W]5/8 o͛m+xgRk痂 8LMOqVwR>9*1xx/l)!ƃdMN*%ղ4Xnaj\R'?h '(5i: '1wK.nH+C L3HogjOb /~Bğ#;Vp#zaåd( r hL+I%"!!wύSQ)*u?ԕv%" S)SDF'Ѹ'/|a}%""fG I@=gBPW=c\۶Ν+2gO߉@P_=h"+xo[ !_mm۔xFcݜ17jx1t+1X*5Una[k>TV'ݡSwcW@ ~x _1 :zxEtpz`ijر.|#^xh|q%n[ba/ mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUUUUUUUUUUUUUUURI$UUUUUURIIUUUUUUUUUU$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj ֩?ITj ZAZ֠P_Z'R/ T T@Rj ֪'P_j@֩?ITj ֠P_֠P_Z kUVUkOj@֩?ITI֠5@֠hP_i$DDI$DDI$D!B$"H"$HB!DI$DB"$"H"$""$! WWfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI*Ivbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??T C8Ďa@?`F?`F?`F??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13@7ϻ| MBf3Ŷ,c<2QEQ-]/qni|Fr;jaEeu( Te{Sl(B_7,G -T52TeZm(ݑǐ**i9=gu)NVWI9lDQZ2,g1:)t1aYǛ r27%ŢFsU4Փ4;EtEŲ!kƣˉ-X}/h^fwʊ:?G֐Ӓne'P];^]Z5 @T֖gbAX53ll!F[b׶ipǏhT՗:iםwM+((ɳ)u&mun\{C׽<$3%FRŶ8UyN0Tz"maS]wvx rG뫀:No;rcj_E llsm l! 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@"M@Z@1^}\xg媇׳2YnZ)ÏBAE(ҀOV~̴KȻ=HzDn"&uZe638ܨIMh^L3J%=k'OUqOg!gIƴ g^)ZB'+ҵXuOd8 `bN4i4 \I[9\c$Boj'פh^]oـt^~a9Dd+UUFƁ/ӊg 5FapGT}?tv(4M7? un_bٳŀb(8DE1*.lw2gK<–kVsVyZ1֞w"6cˉQl @I~>OsW(@}-)?@mc9 U1NKX)L.,!)3yQݘZ4$55BFX~!Q3K,ۗtYug)ˠ w8{\MS}[ܭ~)<`4kZO1qܔ}nV/*e9b K.DȴiR}C 2LH[=`` ]9KYiwmñϠ<2Hjjg Ì\M2oj_x\`.5n%D8Lu}=Ö>c_0MPdbiV=M]E n~ԟ"m4H3λm&2cAѣGc]yG#̈́Mf㿲=cw`x<~Lu͙ydHwkBw}"|׻2]Tן"?g ySb& MU BZ/N[kĈN⧿g~xbt)WLq?usQiat2FU5tzjk(:JM} ըmލlVL0>=1p>***}ر#'İ|-fGЋAO0}RlNb$Rmx=^kVFEEU4^zR^[sx 끎ROמ/xJ8ph_&ͼ;Mѳ;4بȩ|zNFD!E׻piE7 jeμfYR]v 83!$!D%.WϢHM c)^PWIโ1SnNs >}3d+ڜS?y{8s]w9Z7˶q7ۜ@q1Q#D 3y(1F Hѐ)~ׁN_4a&D̸[%fm!!]pʯ8܊k@}˖3eu$~iwׯaDDPdN@0w lPQS̠[p7J†N_ol[Uo1Q KEUeֈ&/]r;~o':HjYxXt<_jt]n]s_(@0uzEEIw᧠0uF>չ,oht __;|}\,"P=m1t8.c+V`ԩ+22E`'LB~:7My䑤禌YfƦU:º_M47uMJ[nʕ8Uڪ{7q5$I0р1TT'woE,h4)̅EKf]͛~ *Jh*6> ad <|w1EtM:d pɻ湋[hSc]Ҹvs;/d;wݺY46$%PQ@ȭ"bԔBKKK#&ΑM؍q3Meg"'Y}MLM-jge|x;k GhƶmxBQP5 >^.K߆aF-؂9&mw߳o߸;KmoSw}>BuuیJNS7*3!Au+roɪUr ;ڥD"a?RKl8O@d 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'S&aۘ(іB̈́GyTr?S]7L9S.GΠWĚϫ':ܫIx )bD4$܌[X8lbb{: DٗHMzqF" cBx طo6l4lĤQ:g '`斺khc<]A=#fv߳g~_ 'lSV7V4®]thpb:+<|xP0=i(TC|+|ha) i߂q{c͵aČDx[5TAɘ3?ʴi9zFJLPc'w̱o$|(HL0v ӭth(e:f<(EZ)j;F]] WC)ᓄXܬ!T&t72+ئI$GQBy7wq \|T^}o NOH5Vhj)hlDz@z:a`lEiƁƁxWDaO]@'gtM&*fX:v{:Jc60Hj7/- ݑM^~vz2\T-d)p5`VF\bJ4^/م(M55l4irYk@my1kop^~9\( ¶u|yoZRQh^lvDGyUa7V#pBl2 Lg4EM$҂-ly HS`7/T20r jsa>]td3qŻi<-MMōZGFG]6 MT҉Sro7뉴߽B8#e$([rxg(: {?0b$9R l@U\^w$LS_x^u`Et 蚌VVV g;ahV5MQU UQT U8g< 1e 4Ael;Dd_񻙝՚ 򲇡*2G*˪ЪqT87m%dK+OŖZ7,t ĔWy<*FGWI;%zngUq-Sr?ws3>q}5mA܀rwK*ٱJfHN`M[]󢪚+p'wOb&3'!wHje1}چrr{MSp>Yq̞K87m 4po2iMFΑNZw۶ܚcT tC350pC ƺjb6F؀M[gr8 Ǩ-, p䇤.tx(TUsw>ZXzB&v[g0&ԙ9HfU Ɵ33xēzD8hhB;299H8/1cr,BIQZAw97/q8Vi܂y@p47>9$aꘅNzk@񜃋ɣKKz.й590s -۪o*99'KDZ9;ǔ1 ,nLvmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 UUUUUU_U_UUꪯUUUUUUUUUTI%UUUUUUTI*UUUUUUUUUUI$UUUUUUUUTPQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQQUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWzCCC Cj %* B JOZP_?/j ZV?ITj ZZj%*JTZV?ITj R?A֠A֠jBUZU?JjTB֩? jP_P_i"H"$"H"$"H$ 0DI$D$H!a"H"$abH"$"H"$""$a WW#UUUUUUUUT*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU*UUUUUUUUUUUUUUURIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???Ӻ$??7@@^5b@?`O?`O?`O??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14&PNG  IHDRc IDATxy\U?w꽓tB a%H'8 fGeg@AqtQwa ,D! B!$$I:r={nZ]]ynWu׽[;}`? p'-x͒uTuJ*RH%RWTp(%J򋧿W{ LfITH0<00.OH$B}^9.9b,0L0&٘{H|U!>d=>{?})Qej R=>y$q-xg1,0 j'=XtJIz?2El/ع[ /ajgVwCFMӧ̀3Z(m|s=sNӴLF '7 R )Š-gXi +sW'@ArB97|6mamcmq_k45D*D@I t}KiG)v_S֒HXZAGo)y?7vuuwF{[ptӝZ)|h)I^E*p`z ͆aC>ӧaY&{9y4DߺN,ۦ6::젣Ύ8Byۉ ' af@&D3xݶm LC'=IU>IGG;n~ #?IAM:1-8/ hhHR]ut(sy4r$6]ZUJьjZ G 2qL4 ,˗BJ)w)TCmm㍸E"Oo5m L{`Uu'!? b$~a`Y>#Ќ$ ;v1ڥjX7!J4X/R"Vh'f<*cH ^P. F~%: ɇ ܹl0xk#o!##h_Ҍi4J0:ʱv$;Jm`YN*^+(o铧0G)6L_<FMÌ:-E)ɖFd,CEF<5@@ @F<'~` ZFΨvz,*̑, u0& ;%c|TӘTƣK:%$HʺƭJ*pGs臄LQ⑍M8yȓ8> b(,Uqt`{lCHÆi%XH#(¼`΢2:m*E̎aIg˜T#GnU>j`#nx%'$-u0 q_M8#6ޱ' MKa000 mAzTJQ럧 M@cuaޯZ^vs(Pˌ 8^m.dO%O#MHCnN!]IV\9]EMU#/D,O(&ȓQ#es~)Soɓ"=Ȫ}n9&0Q~+ WTh9aU$"#|$F<JSd ^jOe&hk(|sdcoXfàjR();OhyRt^[O%6dbRtks_ WЂ.LϿah`ԃ|(bK!9 8RɊZ U0WJ{2]-:i%3OWi[qbvMwGe!yEV~Wps 0rfbˎe":{:5`_g2 -ъ7]]dtROR"@JoD1;&-Rzr LOiդqQey2 Αf=}Ooكg1c|]R#PJqϣ_<1;N1 dChLli7L?\_ci@lE n8?[Y[5!=d@!]t98nwU+o=:^)bUB~Ï Pvш`V5ӗ9ܾH9ļBɳA)|("?\D1;,k)# 7 "ːvNm~|#6K|? _'%UIMȭRu6x}UeSg2M4[wm;q E~*aHyD`BA^>B`|ō"MX<(U#rSpp'{}oPF:Oop,3Ju>o5P3DX)3 uB#A"P=8n&u8ӭ lDib!)$!9˼oZJj$x'v)fmQ0 O88n:H I4LbvXeYXiZa0SqԔhfqL"83ק<7 tf@Sx>ۖLFt&!ܴl7VqG8@w-`TNbBwY%obȨppU?V]`:j?*$ݏKˠRP:Oi w*BP Px"/LwdUHen5 fM=.B30sCb@sG zt,:_Wqϣ&E)xuþDzyC[y9sLROQa쉮L C̠lX~ !݀t2$ݾ߹^ ,a̒GVg]*xts/F=O{d WQJ/O)wi|dZ͇1O0bѨ2f`Й:\JH7oR!!TВqIG4ۼͷ[!F7lx2Iԩܶuk1aosܐ/mjji8pn"@&ɿkOA;D5 ΈQUo1$W^I<@EbC4q!@ ARTJ1ٶ5 j P)$*+GEy<xVnV=~k|6>sUW<#,[;３_*RYz0M@hFppiߖYCԩT74P@"$^YwTV2d-%aץuiq],N&phc0XhMMM<|iw}f/G?=aʕy,^ܹ uzYL4; JtI?^ێg4Xzexu՘p]b?ޏ}˗i&:E]uapDvV(^yiN dpLH6o/!kۅ)ZRx´,`ysۥ$!ByA slQkؠO}S M@7u[.z^zXuZBpދL޿<ðmb?mW <{ Bza$|e(L?Ӳc1x_vK<9JNǡqpRK:\ %X6r…(vE}}=J):W_4a}vfX೏0o+\jk`Zl~'l 30 )Az_PZR8xg@-!Bl6`x.Jw|JIqi峟o1@<gϞ=Eia`f Os, ;xmdzwo愹1M7e=3d`reVa6ɺ:xX"A"[q8v" COmڛKI8>qg>S.nfVZ7M~YO$>$$iھ~,@*k0ᱷ4ʲm?,#8"lR)f,ݭ#sXl+V୷k)y[wmve۞k"ո#7\;7qν <GnhWSZ VKRpɭm1^)hy YZ-ZDee%455qg~e}%8,!o;o^9($@x+p,C t-u= m t3x3<w})W[Wsz9^D_^|Pa> yX/gu^z)y8䓹{Felc J bWN[JμeYl/ળlw7N*=/y=<',] \7+ BE"=Ŋ8Ks+9_(ݝcP__ݽV\Ɇ ՙ@<A7Aڶo؁^.#pf>yR)ҝʥe*Э4.r-ر~cOH^:3RKmU8yA-ul({3_RlX߮8 %: '\)~p}yX |ZH ֟H:s²,E4M3$Q4tjcL>+e<1H7{w"K}уTLW=$۞{x<%0 ,Ea0 ,DVyd߬\ + 9~ۆ ,8\Q*O%l۰vŎrᏁ= )JaJ  :f$eB*8\M@N$x3g~:W^y%g~q U߶aC(Hž(Exo7}@6ɨ@Ig:R +㤓N/e{ߚ/7Q6{O5oJbaYؖEUvӧW|CYgGI0GYm9p[9g? xz#/ɇyh^PWWE':޽{ػwRvPTŴuh)ˁ-KJZC ? 08k{/ȥ1~Azk:yN47wr`׮lԷ+f,iJv,CKƒ_ $1l$+!ХaH73 d/To{.[m+!CEEE 2bO偲!ϡݻ2g/= @Th L[2Л-qbml,$%AِCȓ PX)CDCBEN&;F~|)7’%6Rshn̞O[ZUp :NqH!?yk,QQ1.l *N"L={wB4(0 <ʬ:(hضI{{,u ^{>,Y7r+S3fl_ 1ƷSfBD|-IDAT3=~̞Ȕ)V[b񿾇7ngK8#?%@!ezŜo .fl`J^I,fa= u|gF^JC&Ϟ(JȹE;;;wtuX<xxc,Z t H&/[GD2bH!)7Q3zi}&'M" 7% Nij45M t&Zvv3fP=iʼ2;Uт߫i1۶l)xF <]]M|xMJzꛚ| EyUag1@5*"ilZEMqhmjT![xEM zF52LbV]@~_|TbtPPoLKH\iLF2o<z]IƱpժxUzD:DIIRz 2Efj+CHD1AN0qJ[N;$*mO.N&gr+8zE`|z)DXo9cLm +UloqD"ƶm͘bcG!'y'փ˜(y" j8lāqx<1bJsoI!pYIwtd2#2R`0_u֬YM[{tȔq[jUn-yFsb`HÇ9Yd h=d½q`<t jk+fGЗf8lٲoGǁqE ,ƍ3y&P0&31A  L`Lgc<(@  y&P0&31A  L`Lgc<(@  y&P0&3mq`IENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 U_ꪪI$ $UUURI*OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW>zCCC Cj ֩?ITj ZAZ֠P_J*U'R/hUj/j j kTZOրP_/P_/Zj5ZkTZ֪ZP_ P_/h"H"$"H"$"DB!DI$D$H B"$"H!DDI$DDIDDIB WW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???>6$??ज़OCb@?չ?չ?չ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 156"PNG  IHDRc IDATxyOUuO>0à" ʦ!05.$zh|s7fM▫F} QGr%&YeaedfQKw3kT3~tׯssH<`P'%x?-.bɒ=lZF~*no *+=֬)#G>nQ]y\;ZSUٳe9M8wdɅ$L"~;0acEI nk-A(6m:QLw49] n)b`<`~RQ7˔,ٮټ#~F lt{wT9MseegW.2.Icb?!@vK乾MK/e˖I8}bȐnTIqjjjBbŊNN͇1potkIi vkϝfR=I͚5+nvrGH)yw[:u߳s|}{n555n؀M4 o ~ϟ^uTUk_Z2E>B̜t7`@`!"EAU4j+?qExW^y[o>}u:dדAQQQˋ,]ڡ*,,>3f0{lO_)OX0?@J R"{$.C!u *YQQk>|E|!!͛TTTpI())IZӦMtpB.Byb_`.$ gs9zT8t a\ǥ"lA0nHi:#ŗJF %/PU꣩=ޡ 2dwKN>{ｗ4VXv.mZk XkG'\P}ptYžC3?wt1 cHiP@ݗ0ItRH&şT?;Jy>+SY M(C~67lөoIYWUH6%l.]Gmi*N~>;y*kb9=xx뭷Ew\O?Ln穬>Ɖ22zTC8Đ0i(`Ǿ]jg455q]wskpB7BѣSVVF߾}yꩧhnn&w/W&`'O%+#z AP@JJ:Gf#].6>SN87 x ^~ex D.2L=.77`0Hee%_I&y11ZZ3T@mC%9z֟49Y| K,_dܹ曬\5nv;%_jzbŴ2ѣB2ΝˢE, هdƯT?Ň7siѼP;ӦM;d޽p L:˲ϟ?`0ȢE:k8'g{yo0qF %̴,96;#ԔLlKl/RUUŸq={v2q:tիW't~aa!KB$ܵk{/:kC/Vם$ȶz衇xg"36}pAA]' ov4˻t~w<6-[1ރBw]N>ͫjh$;9v+~;w+t:g=(((ꫯ~Z|}c}hhL:'x997m{֬Y 8Kr.>n n `ӦMdffO:t~=ړR]Mhœu>]%@UU;h<\0 R`=eNj]b̰k(*M+//wHl.d˖-l5qƵ{ljj*noO0pspn+ ? +o 0fT_tMbΝ;;sm].g1°Np"T (BnH&q44 *ׯwv!tRN:!z --u,_J}]Wlt[B+6TutmE3l*i~ae]E*j@gɓrї^( 6l鮋r.xY**GAJl]aSi)}qՔ$%8,휙˂9O 1{:t;rIQTTbnV6?$?%gc!<~ P0:CfnjйrtZC/ cڄ;AJ~~c=ĉkXj#Gdyڅ6˔7J)7lY**-4;?a/ [hCH'?=:W]'7}!ESҬ!][g}׵6EA(*kqcƌq>R3'k.lB)% `emɑm⎢[*W%YL C2HPVFNo ,H@G˸|dvtWmŇ_~=ա BMi;(**b9P|gUUl3lWj?~ *;ۈQ%iA ˎMJL @Q ZnߐHC:т󻨁UBaBMaa!RJ6n D^-,vk?-r*^{F`~Ț+#jW!>7zNRH!)p3)f"0'܆jͣtBe\ϦfǞGN %?Ui)SrdCiuWv#ݳLM8&fzĄ9~* 2W7[Oc2R򗥿f ))cHd$9`A+t@i)RAPK -7pzԃg7k_.';<<=U[_my-!W/0|xe&rv1[JɚE7^W 4UHðM(MV˩&jWT3x$5[l:+ EQ򀚪33Lv|̨վL"y20tw4l@Ga# #/\*-'"D|݀ٶ* _noe_ɰaկ&$fZoBnHCQTRS2͐߂c+`/yg3ɢ*l=7S#M?w~wۗŁc'8VkP3bI]x G:}7wY P`UV5x[P`̮.Z[dX 7M=:Y]{6ax8YCgF\Fny3TE%n9Ԉ_Cq$K6gVe3 =j:yNE,~ZI$>)ƦRH x'D'#C !j"ڌ۪W;ۚ4E4-jKl4cX< !@R[ ~υjE^_ MwZw1~HFW0 [ߖʆ+q>IuvOuy\ ]׭фbaW^>Deq`ʗ;Υi?!ihh_|[b<ɨSxw|08*q҆j=vO'ހvD:.<|$¼K|-9CNZ'}!OCC=H)Yѩq!s#=*$fЩg<= @KbqQi …yLwTG!hD3'As9%%-)dGȓȭ`` b`{='Rp -,F6\b _EJɫ?gObcGqpϡHie҄dT'[ HOBJIegIiopqv{]u+\~Ӟ>$P<]Q{~_ j:BI$>+oA},TD(8tɁ푸!in{yx'9HOFJIU3|x[.hXL;/Ϊ#qFeH-qE>}G3X13&~ #OɃE' (_@X8P?yZ>nRɄ$pX r2+y #%t kee < !rC*9fc^lI]C8][b6mc9vȓBᠣ}Ls"lE6Z:]g82 hs< j\+h'3$:#n'*DF^QD6\]ħ,_o1= T?Igà~b%2P0 c}6NrdО#n2n"no~TAG ͚Fe@&. [`H#cZd5) Ynyvcd"-IZ ,ge;2kNC!g8`g.M } (HJ5i|RtyH$)4hH &ƑG8 nJ)MS'62[4-DH ? /0t鏮5V0r3h;-ٓ1h5Ot |$$v':EZ?z ]ӝi 1v7  `uѓPPv`)(;4"$k5 5"Y۴Py6VY!̸֜ˮujRj95)eH%eW;" 5nfs%5%˜=|mI$uvӑQU6r2/@Jc 0#9Dz Iv=, C2FI|O*0Э0p8ȺVKyD&lU&΃#R DIŒw9wUA*QHSs=[ˬ}mE D):Qܮ3s҂354ՇOHKbq]Wۗ~'h 53v̱gĻL+*9bHPJ׵5.ta 4i,",qve!8X+"n\?Ck&OShM>r.>G[ELEV+ |,< b]͈A]Y6MP8"^Q]]̡#( n%NUEHjr{/;R:U^5#_E3FF*jE(-sEyj{@ʿWptK8)N} $c/k_HY A3j+m s"^&IDATm{G8AOK׿J;mW ;gDTם}{HhإwaH7T˰\h\GM0bUa &(*q.^=\ 4l)f=Rb N,Yc6͠FE/KXa2*g։R MY^\Kq,h@c( 0v )%r~Ň7ݗBM.4&ye&YifY sʰGwDUΰzfmӵe\gME Ͳ|wҬ`[n=I"20 Z~{~HCgpi15Ss0W"!]AA]!%ʶEwT7a&BE ?GQTk{UZ4HI3;1U@7?8Zd%J*A\d 52Fq:kE]B$ Ho4_JGVIENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES13KWO#0 ꪯUUUUUUUUUU@UUUUUU@UUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUWz Cj ֩?ITj ZZA֠P*IOZP_JRRUT  IZP5OR'Z@P_/P_/Zj5ZkTZ֪ZP_@֠h֠DI$DDI$D$HB!"H"$"DDIB"H"$!B$DDI$DDDDB! WW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUJUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIvbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES11JI4;j ;j  WZ?UZZ?D?_jUTjh֪#UQTGZUG֨UG֫֏QjWZ?UZZ?@P?D?_ZjUTjh֪HDD$ $!$$$HA$I"B "IIHHDD$ $!$% f??I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$$$I ???I?I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>vbinding site for residue mpd a 700cc7.c1vbinding site for residue mpd b 701cc8.c1vbinding site for residue mpd c 702cc9.c1vbinding site for residue mpd d 703dc1.c1vbinding site for residue mpd e 704dc2.c1vbinding site for residue mpd f 705dc3.c1vbinding site for residue mpd g 706dc4.c1vbinding site for residue mpd h 707dc5.c1vbinding site for residue mpd i 708dc6.c1vbinding site for residue unx j 820cc4%%1 vbinding site for residue mpd j 709dc7.c1 vbinding site for residue unx k 822cc5%%1 vbinding site for residue mpd k 710dc8.c1 vbinding site for residue mpd l 711dc9.c1 ?333333?333333?333333???????@???$??`@> a@? W? W? W??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 163PNG  IHDRc IDATxwTߧ` H_EVLDYc7^sը7ɍJhxj K(( EeYXM=ql/z3Ƿcw/=;EI3)i[8Y՞.]h>3^ۖSx _ʂҹs[dY6ѽ{O22[?Qi=5]!VW\{ƶoּ۬YCž}ht;qH0 {UqѨ, y*{wDǬۢXeaYBXB ,QX_椷m 8=OEVPTpqs_EVNtae0mX lEX2GU( lܱ/LSv|jhzЈbZ8dYj~4dIƲ1{*~hZ`i.2M$Ij^ ?G4=֜>&ѣŇ" 6\cA'͗0-57祏 ?M aYfDE˚8&f#) @7uc%͟%,BF 40M͈ 4=qX8L 3&a4ym-KNz IV 28RZЬ"\_Qh9.yL3$W)'H)KSTbE" &=d:>5B¬߾/yr|G 2Z8.paYMKADUXB3b;]jG-;gY&=lE"W=$/MrN=0,5U졕V=Rv?N ”$dI@ZWưZVX$ ;RLKGӣClM\5dIBBYFBg@B@pꉓX{af{1={Nmq$$$!!IБ~Y\^Hye߼֠{n(R\wSRv/ǼUN~(MY˧ߟ5 ,adӎ.jx1n>;>[-lW18ei|؞&p|!2Pe`)| AsCش C'GBD0$Qpx##Іvm:s;SqbeR ! a6C/A`a*:qbQY$IFCdY(6ӾmwC(̙z!pMi!"%UE5Mchz ;7L;}"aJ |/NMx6qlo[Q Lh L#oe14#4~=!d98D2PEiiǾu92.t*Fq}}'mFsSпpNv~_:_:Ym;_W:>Oi"Z2ؑ:#>BYyEq \2ΆB`: Sa:^ۨvw[i(EceډUyJ5LYV ;'YX-SogggW]1baz~}_VqBA|il|pGQYQڈӼr!*舞5"FmMSaxfϫ=k>vpP$Y9l!>BlwE ~O;s{{F f3Py]:$#{ǘ#vh'<5Tyc>N~2ot;$DzePC"Z\*®ly/I:g内 I\4ጡ%Y{,Lv|Ke^uLt':|*7ysFYNdY}Vt#NsdIVQ/ItO SUjZ*ȲaļQmyg?^-vt`8ifYף*6Y D i G y\n'pWk]̈\霉"*ceY!. w]_!Ҥn}uܙ%>u7^^*, 0I(tnİ,!TLuE|TE{lp~yǻVT?1-w[?:VCyݧ;?NL badَFH^vIy!BXRuEn!~~a*I>{H.ɣt->o3~$II#CG:yߜ@0q![0qO!,I .'VG@x$3{Th膎iiZ}QO; iqvd4 4gMO>8ܭ{U{7oy~^<."aY7f1GCyXɦ8~?E`}$C`{p.+/`XΣV3G]ah`ϩ=sի{&++>Lݻ qQDgzwFf:{`3_F- %qsbUyLabGJpO:.vo*''OsbҤI<L0>EQ@VN;i VG1L@&];wYm:9g vlٽ. }l%e;,.bY;پw k 88Nbĉ}ҧOzAzz:L>K2qD;b³4Xh ގ3zҡ7Gxǜ}Ey'^SHΜ$IHeX u-Ix,{վ>~xx anEQL'ĂWl۳O`^jv|Ɛ 4=XӪ5Jq˓"}UxR՛hئ[ׯ]vU{̪UY(K%lܨrtMgGȒQ@eHMEŷ[6~UUxo/kkWrul\| N)azb\NlǨ}՝,Wxd/Q-D8Vaju"i١qb[HO *~{i*e4mgtl=є)5'aHĂFt[ w|DhЖ1Z "=I`}j.UU5Td|ĬklR[ukܹOMNM=,`{=YdcberBR̚,P^e:i3qO^]rq%#w^^|EoK3vXƎk˅(>(vm jD8ZFY,ִtN~r\ pʜ5ʦElUeB#F'VQwd=n < a*VYR;ٺu+~i|q=\VX+PbZv_CjB0\LLcvXON,P ͅ=7U/JTDcTGʒ-Ua..;HLiMS+^Wt$)y׿2|6r ˖UV]zu=fl<o!ЈjAt=eY1{-<&΍7;TB?jyl^T<ׯV;+.;û8[bZb;h9fN&L,u]>ٙnI˚hnO)dJqAtfOJ$Q aO^U9̃ɄvGBKu^z;c>^r‡OOp=+yW8ou|~'˿qF_F8t?=V,tL TVFZ;.QtWફmv[釼i5%{-e!;mSBD+q7 2_N@UT7ϸ!m3;xoo#bOad%,CIOkp<[˨ZW<$*gQZV]]^v8(] 1x"2_Dw'ٖGiYL}%\Ϊ~:.233*6I(JQV{g^@.BjOxzeV_M8uS'*pct& fԨޜrݻ'ҩ ${ӹs'ozOĄ?TS*tP|Gi۶-F:Ϗ۹3X5,NJ!xs<}pDaLZW588UQXflq=LzUW>%z]Fی 81.o݇e EQPUU}}5zd}73lvU2ui~x6[RN;‘3MJSOW^N;>n._ϯ~ULIAAݻw,eR&fk [G.PA]IJ#џ&Oe߾< s@`ЛsSm{q'\N=5X N={29\sKU7uɌ۟ZX%KP\\9s& /@1={#`WZmj(v!It^R5>ؿQHu.]=Ιs?-]BzHII8iҥK믙2ewq_= G}D޴i | D/dIO)U7l3 !̦H Lur7$1^{_|JS',~NJ>qN4JKKYho'gl2:vȌ3ׯ;7ol۶iӦUym!,"ഓŒ=gYz5#FHi.n,CV ]PUxBO<=Pm͟?ߞvsS|XΤnKY^lZF(Y8/gh9)o?ϔu0 ]7Yf/_~iW|0g q6o\1ŅԚnveI-Cuۖ1ߙެQ͌|cЧO.”իbYoM6g{m_햄TS-ܡaj,$rT_fΝL:sSr2u!TYoDc!'.ٶg4ʍϛ7<ŋY<4 >W_}5@2JT-h dRIDAT+7.D` 7\X/k'HR_~ۓ5U'0ObYp 0%ނ< SOWA\cm=ؑ‚ {ｗuakײj*o%o&?<=zuA(@9p;9`p6>%Pǘ`}Hr{Ǟ={Xp!sIz~;sewyoK.:XZx{ԼF(to"1r4iՎ䐁gD$N=y2ϾyW<~)I̯?Lxԩ˗/'&} 7p{n-ZĿUw:!ȴx.ZMs[{EB! Vmw$mZ_^e;Us; ؈s^:Y (+u~_>,{ᣏ_Ѹ::E'VSVphGT屖ee1$ޅ 2yd͛Ek-=\h5d޼`ٕ3 a[ThXgy&P?e>JU'Gь!I2ϾyWsmRN=Pb9HQV"ZM{G!v'UxGBV>_\t+[;9m0ITϨQXV1{G.&## ~?=_~9^Q-Lkسgf͂Rn"\ߜ^Yb1n9us%[Wdp(evSvOJ6]qC!`S>ӯ0`wy|a:K/1t&YpG ,ॗ^J^WYYd{/BՒG:Yu)'nļ2о]W C$U%gyk݈%ֆݕm V\~MMhUsUh78c[=N w7 0 ,!3GO$YYM/N"ΎuYG(s^?3=&8k›%,Q3K'[8@P< Hvv[9DJ@ߞC=q컈F#T Dz"qv[W}X,ƍsWxtOjOj%yWg0̶kGwb[ tl hh]ќx{;B!G yC"~er텿YseT[_w]6uQ3Y^XbƯtUtM5j e3HYA ]ےɲkm;u:%}ѯ0F2ν&ʄ*RY1ZAp]:Pe"+bɤed +J֗_K߾_Zj $I!Cjoع;DK&߉eYdfd‡R x gu%nNe4ؠС~?,;k61nU:I #ßޝ g>fXqϷ(f[_EQT%!_ohk?&FCsޙa4-y{|*$&ItPTYކІ_>؂d 83~GwG6+]ّiib:ahM<;V h_< ]'ir<%`&w]U1(s\$)~F⛍~bŽ\!XiɣXiz,Fh+@U,B$xVCNd6{-ZïZPYr\5lۆ0Mh-fػ6huhX$ |HeYX EU ATI,4fA`G:Τ?ٿF5^Ѥ~:޲L$ʂG(|)jT뇬6TVBT 4ѣQ&^f0Lj٫( ² 0( }~<*$h[.>u!,~rgI8Zfwo>7Gm:AJC8e#Bظ@aMGS }CCТQo0M%4n(RuIr$%+_n[2; ol4$U'STb۶pjO mt=nb">X= XA4Au` 4$s$Xr99لB1x[rN: Hq>o'ݵ+{ L2𥥡|IBGDA񏩺5ftpDx@$X[~4GơC{Qrm;Νϧzuǝs≩X.+4T5GFc1Nh&=`Od$kta *4bя/^' ) [SGgDD)]ՆaꔷĚ56v6>}Hy9_USq  B3oSo\G2n޼Iܼ$(j-n fE3Gk_ @ 3v:g?tv[q粌,L`uס>>r z$B哎n X ǨMΉON~o3*Hm~ @w,&^{-K_s&X|h89<+Rs͟DZFCIOL0$ ]MR[ p4NuFXB#5/I54^\e;ܒ,#$cYa`F#./l@aT15nD|eӀNӤD׽!뿺h5 +!FHi)z4ZܟrrFӤJWI&jԾ~Ѝk..XB!bNjL,"] ǸhD>sfJٳc1/Ш|(>eaEᰢ)D(Du=drN<ѳ4² w.+ , =K 4KDmāx 7l]ӐUt4eUMs6t)k5CX$ahjh3u8ym:z,F޷SZUݖ)/<-à4~nDkinSٰ!nݲj?AtŒ$,'Ēhu$'kJ$η*N X%մ4}= Lф;%-(ضH,ae!9CwEUBأ2]4`RfG!Ϛ 9{6yFjN()I ;:@@e )khAmt8#DX@̋xjp9@ Y8~ʮDŽCP}{ T%'f*x1"I@!2ab'9RS/ EQ=͠E<zWgdX)NaìXq7O?)\MG`,0976۶ZwUDٺ䊯V++F|Nĺ.bѢ_ki(Iq4d`4u>5bBy<.IJlVM7c}e23Ńg 84l SUJcp6|tj_>@'?O}iӾ=im$9Pԧգ3;O|M.&\. f| duIQ~/mͳ:AX'_?9AٞGts|t눯 çO6m #*I:{L] ƍ@ff;>{uvCvY|LBl,@: yZ@XlTp'L]<TUځ|Rz-ؿcOr21,ٌaX^l ɳׯ5ytlIWk񒠴HNT3 :ia:KH=Zuk!]e-^wkgK/}!V]6 ^2IENDB`move=1000;blend=1000;3KWOB1 \ AI AIn  Cj ֩?ITj ZZA֠P*IOZP_TO֠// Rj֩?ZZAZAkTUZU?Z&P?'ZրR@֗$"H"$"H"$"B!DDI$D""HB!DI$DB"$"H"$""$!ZAOR'Zր֠AP_/ Rj֩?Uj/j j kTZOր֠P_֠P_Z kUVUkOj@֩?ITI֠+TAA@ "$"H"$"H"$H!B$DDI"D!DDI$B"H"$"H"$""$!C֠P_jTI֠?/P_j kTZOA@Zj ZZ@'֩?jA?//VHUUZZP5ORkUR/h P_P_iH"$"H"$"H$!BI$DDH""$!B$DDI!"H"$"H"""H!B$9]pf$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTIJUUUUUUU$UURI$TUUUUUUU*JUUUUUUU$UURI$UUTUUUUU*IUUUUEUUTIUUI$ITT UUUUUUI IUUUUUUURI%UU$I%UUUUUUUJ$IUUUUUUURI%UU$I%EUUUUUUR$IUUUUUUURI%UU$I%UUEUUUUR!**UUUTUUUI$UTI$E@UUUUUUTUUUUUUU$UURI$UUUUUUUTI*vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1ubinding site for residue zn d 161fc5&&1ubinding site for residue zn d 163fc7'*1ubinding site for residue zn d 164fc8EE1ubinding site for residue zn d 165fc9..1ubinding site for residue zn d 166gc1V1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES001met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES1vbinding site for residue acy a 152ac3(+1xvbinding site for residue acy a 153ac4(+1xubinding site for residue zn a 162bc3(+1xubinding site for residue zn a 163bc4//1xubinding site for residue zn a 165bc7FF1xmet->mse selenomethionine MOD_RES1xmet->mse selenomethionine MOD_RES 1xmet->mse selenomethionine MOD_RES111xmet->mse selenomethionine MOD_RESKK1xmet->mse selenomethionine MOD_RES1xvbinding site for residue acy b 151cc1&)1yvbinding site for residue acy b 153cc4&)1yvbinding site for residue gol b 150cc5`d1yubinding site for residue zn b 161cc7&)1yubinding site for residue zn b 162cc8%%1yubinding site for residue zn b 164dc1--1yubinding site for residue zn b 165dc2DD1ymet->mse selenomethionine MOD_RES1ymet->mse selenomethionine MOD_RES 1ymet->mse selenomethionine MOD_RES//1ymet->mse selenomethionine MOD_RESII1ymet->mse selenomethionine MOD_RES1yvbinding site for residue acy c 154dc6&)1zvbinding site for residue acy c 156dc8&)1zubinding site for residue zn c 161dc9&)1zubinding site for residue zn c 162ec1%%1zubinding site for residue zn c 165ec3DD1zubinding site for residue zn c 166ec4--1zmet->mse selenomethionine MOD_RES1zmet->mse selenomethionine MOD_RES 1zmet->mse selenomethionine MOD_RES//1zmet->mse selenomethionine MOD_RESII1zmet->mse selenomethionine MOD_RES1zvbinding site for residue acy d 152ec6'*1{vbinding site for residue acy d 153ec7'*1{vbinding site for residue acy d 156fc1FF1{~binding site for residue bu1 d 158fc3 # 1{vbinding site for residue bu1 d 159fc4 $1{ubinding site for residue zn d 161fc5&&1{ubinding site for residue zn d 163fc7'*1{ubinding site for residue zn d 164fc8EE1{ubinding site for residue zn d 165fc9..1{ubinding site for residue zn d 166gc1V1{met->mse selenomethionine MOD_RES1{met->mse selenomethionine MOD_RES 1{met->mse selenomethionine MOD_RES001{met->mse selenomethionine MOD_RESJJ1{met->mse selenomethionine MOD_RES1{vbinding site for residue acy a 152ac3(+1vbinding site for residue acy a 153ac4(+1ubinding site for residue zn a 162bc3(+1ubinding site for residue zn a 163bc4//1ubinding site for residue zn a 165bc7FF1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES111met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES1vbinding site for residue acy b 151cc1&)1vbinding site for residue acy b 153cc4&)1vbinding site for residue gol b 150cc5`d1ubinding site for residue zn b 161cc7&)1ubinding site for residue zn b 162cc8%%1ubinding site for residue zn b 164dc1--1ubinding site for residue zn b 165dc2DD1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy c 154dc6&)1vbinding site for residue acy c 156dc8&)1ubinding site for residue zn c 161dc9&)1ubinding site for residue zn c 162ec1%%1ubinding site for residue zn c 165ec3DD1ubinding site for residue zn c 166ec4--1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RES1vbinding site for residue acy d 152ec6'*1vbinding site for residue acy d 153ec7'*1vbinding site for residue acy d 156fc1FF1~binding site for residue bu1 d 158fc3 # 1vbinding site for residue bu1 d 159fc4 $1