Y3.6-1h"/data/swissprot/ 3Q7H.pdbdupa 1TYF.pdbH5[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Structure Of The Clpp Subunit Of The Atp-Dependent Clp Protease From Coxiella Burnetii[/h3] [p]S.M.Anderson, Z.Wawrzak, E.Gordon, J.Hasseman, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3Q7H" target="blank"]3Q7H[/a] [small](deposited on 04-JAN-11)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [p][!--icmscript name="42" display slide=slideshow.slides index="Ligand binding site 37" --] [a name="42" href="#_"]Ligand binding site 37[/a] [/p] [p][!--icmscript name="43" display slide=slideshow.slides index="Ligand binding site 38" --] [a name="43" href="#_"]Ligand binding site 38[/a] [/p] [p][!--icmscript name="44" display slide=slideshow.slides index="Ligand binding site 39" --] [a name="44" href="#_"]Ligand binding site 39[/a] [/p] [p][!--icmscript name="45" display slide=slideshow.slides index="Ligand binding site 40" --] [a name="45" href="#_"]Ligand binding site 40[/a] [/p] [p][!--icmscript name="46" display slide=slideshow.slides index="Ligand binding site 41" --] [a name="46" href="#_"]Ligand binding site 41[/a] [/p] [p][!--icmscript name="47" display slide=slideshow.slides index="Ligand binding site 42" --] [a name="47" href="#_"]Ligand binding site 42[/a] [/p] [p][!--icmscript name="48" display slide=slideshow.slides index="Ligand binding site 43" --] [a name="48" href="#_"]Ligand binding site 43[/a] [/p] [p][!--icmscript name="49" display slide=slideshow.slides index="Ligand binding site 44" --] [a name="49" href="#_"]Ligand binding site 44[/a] [/p] [p][!--icmscript name="50" display slide=slideshow.slides index="Ligand binding site 45" --] [a name="50" href="#_"]Ligand binding site 45[/a] [/p] [p][!--icmscript name="51" display slide=slideshow.slides index="Ligand binding site 46" --] [a name="51" href="#_"]Ligand binding site 46[/a] [/p] [p][!--icmscript name="52" display slide=slideshow.slides index="Ligand binding site 47" --] [a name="52" href="#_"]Ligand binding site 47[/a] [/p] [p][!--icmscript name="53" display slide=slideshow.slides index="Ligand binding site 48" --] [a name="53" href="#_"]Ligand binding site 48[/a] [/p] [p][!--icmscript name="54" display slide=slideshow.slides index="Ligand binding site 49" --] [a name="54" href="#_"]Ligand binding site 49[/a] [/p] [p][!--icmscript name="55" display slide=slideshow.slides index="Ligand binding site 50" --] [a name="55" href="#_"]Ligand binding site 50[/a] [/p] [p][!--icmscript name="56" display slide=slideshow.slides index="Ligand binding site 51" --] [a name="56" href="#_"]Ligand binding site 51[/a] [/p] [p][!--icmscript name="57" display slide=slideshow.slides index="Ligand binding site 52" --] [a name="57" href="#_"]Ligand binding site 52[/a] [/p] [p][!--icmscript name="58" display slide=slideshow.slides index="Ligand binding site 53" --] [a name="58" href="#_"]Ligand binding site 53[/a] [/p] [p][!--icmscript name="59" display slide=slideshow.slides index="Ligand binding site 54" --] [a name="59" href="#_"]Ligand binding site 54[/a] [/p] [p][!--icmscript name="60" display slide=slideshow.slides index="Ligand binding site 55" --] [a name="60" href="#_"]Ligand binding site 55[/a] [/p] [p][!--icmscript name="61" display slide=slideshow.slides index="Ligand binding site 56" --] [a name="61" href="#_"]Ligand binding site 56[/a] [/p] [p][!--icmscript name="62" display slide=slideshow.slides index="Ligand binding site 57" --] [a name="62" href="#_"]Ligand binding site 57[/a] [/p] [p][!--icmscript name="63" display slide=slideshow.slides index="Ligand binding site 58" --] [a name="63" href="#_"]Ligand binding site 58[/a] [/p] [p][!--icmscript name="64" display slide=slideshow.slides index="Ligand binding site 59" --] [a name="64" href="#_"]Ligand binding site 59[/a] [/p] [p][!--icmscript name="65" display slide=slideshow.slides index="Ligand binding site 60" --] [a name="65" href="#_"]Ligand binding site 60[/a] [/p] [p][!--icmscript name="66" display slide=slideshow.slides index="Ligand binding site 61" --] [a name="66" href="#_"]Ligand binding site 61[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1TYF.pdb3Q7H a_3Q7HB1  1TYF3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] 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197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 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{6.Q/wg3Af~ٹoOYű>K5[v'~NZNJ_wwMSah]+E@ac,:: ZH6l}vrSۨyWFah,k׎=rZ S";^:qc+) Ee ]R5e e3-FSkԏB" JurFkۥ =}j?Kwҩ iBp>#j sHzaׂ$q%&ԩ6~ -p`z"`,GwdSSS~+( \} ~Hø=UA_9 HO=&X9k6vl=[J |6fէ@LN#fã4k%Q"k$2܌HfJJVR::?dBD y<#u_d,Ɵj _::uXt?@ݦ*iߞ5t?\Nc!١M B"xĸdSjL— |Hlo7>c\8m+(Pz_FsqTӞOO`ňBf#K@iV-Da!Ms>'FRO?-27C?a3( V} ɫ ]H9~D k9QOTEoۿߠ0aإǯ[(rAuoLkE>BG7 _#畯˜J{7PXɉ\5?'tcǎ1|2O3m.6MM(abmkέN f rUjq9>/i)m-wH8%аݯ6r~Mϼ'/"}lLhٯ:sԯ->!p/ϟ/6l -Z$z#z-AB2biB\&DJgum=V  CS庥b{;\5ŴNbcR XFŜJ~7 ݛ{28{\; FJP~dedeenܸ{PT:$ d[2~HO)zǏ4FI̓X5jJ/1y㬿@R]=UmTV f0$-JVUP;sӐhCːө&G 4;} d|P`1K=?K27nV}nEN[!dntAm|G|x*pUL2p ;F# iH"t|c hMM@@@hPɴnݚ~A$IK02ؼEܿE!ʑ_Q9ߞ%9w'LVH­lCܩUDΛa2܊&rB\,W‡)Y.:'^XQ {&|oooII899zCw.ȔN3[m;AS>+TϘ &P|֤t!:Fs| 5q':6hO?md^վ| jڈB,M; SkZARkgqI`?q!  !(̙J F\<ɯ%J`s p:jn,8X77޾M{⻢֌}O)JdP ߯]훨(W}Kݵ9ݵ~>ɶ;wH+kG3mZ^l]B}6nfgaLB^"w$Bs|ڨ/a1ذ#^YTlҲغӐH GWT)Eeb {kHKK :D:3322Lb[mC O}N>UTj`b@"5vt'z-b7rU@Ri^bHF:RM! ,7n4(K|tR&.^(6l l\3rj:\D.VlOSd;CӧyȘ]+kZۉ5#EP]^SbϞ=mxyy www({6vZ|xm0@}?+ډݘE>cggg޽ˏ?W_QoiپJdn09Ӹss~}Wt !!t(>F.BB03SS2Mu ___)Nb[|5w[u5([e#7ׁӧOs!mԮ}ݻw?u*Nkb{JMڱYQHݳK`ضmdff2eV+U;ӧk[]Ν{~ H,ɠBD>8uI[ $LpipرEseeG]ռ2؏G?ⷓ{tn@˾A\ oWZ68t}eE k俾dHӾ޾>dL[PvF%++^  }o@oywOL̨d'ٱE62G{4P:PRC4ȿGv]9HzJ{_T rj~_P@_/TPsssܾy BxZymV5!S!ٙIdFOtҾsR=BCC .ոqI&\x#Ӝ} Mk^33 C a5>Ǐz<^||3}/>TiXk.p7Uj?+8w~@@&Evz/J q ׯsU]pξby ו+WHC.K}E]gv=OՖ9"9"vރvMu\mH}mB m`h9ݢZ{OB}@V99G!؍Ҡ\mbh`D4v]ЉFĸo!C  WDSbDFEʼAHl3U+}|mlrzX7Hn_mߎC@D2>0/e]:4q6{>V-i7> _hטK]AfRxt8˾y_wf\"}h1s1K13ӄc;+I)'2|r"e`7@Jei2hئ)ikpc`բm ~˸ul[W.(ڼ~e,] 7+y'Ha.lrZ6< Ct`jYܡ]9y)]4G.r>K}O\c-^}#|gÍg4AP\9J-Rb)lݬ!9r<{gpO@7m )`ٳϽ;"4//{HFedIKQϲMzXz[8Bw[1UTR_@pr,",Ց9iȎ^W`9}i$/)nQA%JL}h P:bM JU3l"mHmVn\@:6\jû^XH߂.?ɥCgsqssy*WjZO}uo8 BpdW<'o +Oa~$G%f,1]:_0$\+w[nɻ}cܱ֖$/O沽Ss_m krTeL?K-]с`jH9jA"%9Y>!̄{1iE݈4NnL;}Vu]M SѨ/(T[EO3,Yp.ڎ U5:l״j(Bz SY| Hd$#jRTktpym(hz$LQCfm7o'`S$r ,FNꡨ3\:%h/+'\DP"fx8yw[hTla n+E] [333NM"R,0BY(BxZ!Ks;@SM1~an,r՘ /oF504ы }b$upL~n31Aj8YϧI"/0X+=#qrrR|fi)v3qkr1hSU##QG5}>cA˔_ZX(k؈: v4`i\j|G=+m: wP"}Ph&Ű鲠snOt0ڲv£W[bM|IDATEGUyشr6>2.Y\վĀ?W][/[1y~$d~vf@x ;?֯d%f͚%l"l|ZέMÐww1j\Sf z)hCS^c{)XEծ;SG)+>;ްfAL[SoW6уUߟm۞'OgX s"î^摟G9Qw(j6 /)n=Zr6]Nֈ+79a'OLJe̙T=zxbEƞ~?,B#ϋ'䖩\ 63GrI]o_-ّ!hډܧer%=S[UNFEڵs֟ɵxpt$. 444[[[bt۳ssNfeV iKY]zxxmۊ^D@բE e)SL]-Qa_r:t[k%KgϞbȑbĈ [@mkb/7ށWa}:k${g+4kKEڨܰfgV@D^ĪUXd m$Ì*;Jic(>$BtdPrÚmMnD3#QiZ;P.}djCEhv|t}5b`##-͑յmmtR^W[_T@k7ށJ oPM?\rct!4pxv[5* @IQLW!wePuCiғrt шoGNX\plmO{!ҚvSD?J40Uc$gc}x)56]im}olPx^X#{y}C7'<B_Q IENDB`move=1000;blend=1000;3Q7HB12kVV  ֫֫Z֯UZ_ZWjUUWWZUWjjUZծWUU_UWW_֭uU֯WUWjZ֫j__U֫֫UWZjjWZZ_UU֯ZjZ֫֫U_UZ֫Zu֫Z֯j֫UUW__WWjZ֪Z_֫__WWZZ_UUWjWW__jUUVUWU֯ZjZ֫֫UZUUWUU֯__jjj__W֭j֪UW_j֫_jjUZկUUUUUEUUUUTUUUUPUTUUPUUUPUUUUUUUUUUUUUPUUUUUAUUUAUUUAUUUAUUUC Q  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 3Q7H]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???CC$??-5?@<@?@Y?@Y???@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residues6sPNG  IHDRc IDATxwUyr!("5syŴӚ& DEL\]uC;{>]uNs9%߻{g3s\xዿw74cƍJ}+jj;߽Y:'wi}}ܕz/W}Q;Rypr^^U?ܱ_sN| sy%%'4ZGijz+/˟|nŊ;UY{? ?)otPXx4&ryj;5Bypq䑯XvO<*T /gS~wzI_G\ۈ^g=Oa5t fs _ U=Dbvu>ooo:xNUb7(VSY6Hy*8C /ȫ|Ebݺ`;#ۯ0B$PTt 4 ºu`Acq9H$ŋ)**B$^[DZZm44 y/wvO%yow1VlR\X,H?@1&1~^|1V}ZEl5\ˉ>dyvxG/wT];&:a]);2eq'#~ o2rp8%%˫}J sَ! ~ww@n/w[g @<bƌ=1'/(xPTV>.Y;fIAyiC7 :( dyp8 @zZL1cpщ3I獧VQPpkm1CxtyQXx7_eSOT\BUGѫ3jsԨ:y >Wf?-l?7*/O牢:QUiQTtv(/?NqW;w6yΥVd妧eE& Yރ 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Zmw|ƌy  ܹ'|H8] E"}ڷ_@ 71zmAi X^>6ۭ`/e %o.W)/bv˶B$ RiG8w~8'8/-h:z>E F>p;`JK@`pJ |RTW f FFmZlvQfj|Lo+YYKl$wL;~-I$2B8DF㳤$~}1L9M."_pUYJj0٦SqkTTrrdYN3[t-{&jͱ1&aLbzIz\v?@O{7cr(/ ٦ůY,7ñ83egO&Jd4|~o=`!vCup\3}l\tP4=lRE]5G5)O&8255ՐIF byfs-ZtGVVaoe9*IZm1vd7߇cci]PU5۶m֭[!I/q/Nuu{J%p8&`%h::ގ I'k}Y|ga6]6.Ƭ? 1`YM/,Dq"Tp:e/|@mJHqeGǏ ߙb@AEWP( o6TWߔ2NQX?ֶGQaկbk[q1]3Hmۯj>*~1hwqP*y TUoɱ,ޯ'TT|_0.h@砰#HR \T*Dž E B߿,;N5ʜ87F &ӜFu:Qs >\:"Z0TU,g$FVz-M;>h4"< h~  m8:uz ||rmR}-힊_.W2@$"OׇQSS_~y;wsoذx<[a4f8yrڷ_W' n> n+Y "WںcHQL,hn<]RK.yx~nl}1QH2]Izrs_Xw $[V|&Z?$aqu&V|m -X1L;qF=4kV/ C63q?W^cY)y,p8Fcy&,[AfsW@V%/Ll  W BBo7ϕnq/Ivv,I5=\^djrefO,{~ڶXvI-t oeSͧE>k|>M_$7Q~8|8ZGS7P߾p?L1<_!eZ5 SF6۲x=1Iw?ZSqn23'S~d4.̇)7-y 6QQQ2طJU.d0A}hԭ`bٶIe1l7C7lTX8rsGp/Lg},%ӍJ+,ۈqLq v|#F#q9a١)yJew) ӑ.O ܜRfa)yp1̹Բ22U)eNM]>144d˛NbH 22ާ_Ü_p7N,{Gmտ>q}.bAMY@Jʺ>\M1Onn2 Z݁x~"q\jA2ƍԛ5 #=cbIJe^4jy=rmhdyٯqɋZNٞH;[(#Y>%Vڗ,ќOuEv\EMSڻ۩}54xS*F,+{;n1a«$Pvv_q1mlu8%QtIJ}H5vY+`H,u'^x?>d\teۧc2M#AHw3lIz#J 3,q}-ILtg&\ڵ]Ӫ)߃e/D$/Uz:8 >QR;v@돺Oii`'A""B]Q4z*U"r< kFii R}T?|/W.] E!jj؇Ν迎y 9sC&ݎ| < `wʻnsw" m$8.+)fZmA( #3"Wطo3vaX}O>Ab f͑7 2Xy^dgwBSӁO6ٓ.]@ )%uV#j0Rb?xS}i4cDgΌcرt]wѝwI椺Ç~;>4$yr8,ed""2ܢd.%a,Ij;i*pWRޜ믧mcҐ!CW^tD lo}ܸgy 7d4v"D(W\&m73,6^_۶+HLx3j}ZJfČn$ǥ8r%OV$M~+ CIz%dZmjS6Y$6Y_q}?T)ywdid2]j4nE$nHIO^C6op-ZtntceE1Uې ?$ߞp6왿mF p1HyyMC/Ig}( :۩Y > 4`>K02.:k8G< [IENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 3Q7HwoVV  * *** Q  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?^   @, A\$ƠҪt9!^1"%eДDRTME1NsqW0tjF jkkfyxUGuGrECԓÓW`P(x x$` $IY:QNIhx0i+KZ-:&d7-) P3r8-Vk[1ƒbZlwoOQTIƘ2E[۬ҹÂa0TL:@P 0T(B] 5WUNrF8b.s[#\A꒦RgwhkErG5ia[2S[3SR(PကdH@24P#5(d+=]̫*A5l𔇚3ڏi)Jk#lPRn76Y21--2QËV5TuSm a(XG[f{ L  `tLAPN,Z$eCuzu9(0xyG9v䡐 S.7qw.*wDHY[si夵2NL*=PhI[C:0, .p$ Bq#x$N16J rFhC\YEq"^.ijTVU灣e3oN=ޕ"0U a mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???$=?;@4@?#Б?#Б?#Ё??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor 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ٶ1mtm˱<'SqI&&0 7{{os˄0PA"Qӳ|jeݤ&{2SJ%"ZL4t2ɩ9f>ϼ_`gqJ:ZǑv|2^ ۶vkߣ,2nyxdL9Uw  D~|RaZQF,1:5E46mۦG9!(sPSftE: %DQFvm0|nzlGHLT*  =@ 3\8;7J$B=ʦ#ĞzR%0=Qunu:kOpl VW(IB!4OUqlZ,{ll$NݺE xfj#k~a x$!a3mZxW@<1>B<@cr0MYn t~˅b𐝺DSsPPik6nar9Dz4z:&jo}tYUvOb-7a6Oryݽh?'6cDζi*ƯO߽Gb~n|Lp$>QjUX,jy%ҿŋN ezz23>1Mx|[tiA`\ƚ"S*{C,"Œ$td<d*Ff3d0hĊ c v^Ş]P ,/-n7fst:m$E R~ѨN N-J%fV(! w wXzl(I29Lw._귿MqbwW48ˈȒoTPxkj/O0DG@7e"0'Q3TU:6ݮ399,$sqŻ`ggwq KBi[wאeHqOaR(_^;CzZ9l tb7^~Eb?~C#c:rχiضv-lĉDFFl WFu˵p$ äݮ"vh4M66n(&L?r2ӿUrm"(mnWQh ju,Az!7$=yt>4⁁Go+6^?CCPAU멈bMS(8p,%hPĉZ~_Z-lV9uju?LpQELM6}oaC%}~(\I&g{K@z4U2-Ap3%cw=t]cqq~UFFz¤$qarhfMo AӺܼ] O[*uz=7QG68firhY3?,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 3Q7HdVV $* I$I$II$I$@$I$I$$@$HI I$I I$I$I$HI$I$I$$I$I$ $I$ $I$ $I$ $I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP oL:)!                 @(" \P\  )"Fdc%06@ ) `4 C 3 ÀB4@! 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KJal!‚1@٣ĥ0*Ba@pL ء Ѳ18T1IP CM!Yy=2p.o1M 0 ,xAQN;v5#fK "w/H:DEk]le3BGtiyx,ʶ. 2Y<>֖9yڙQd0}BveDedZ,:%0Wc"Ҕhʮ*А/C &(dz[Hqu)EQד+氜,HT|/]`CG&4f6ͦ-Fiwfސ* ,e] )-rd<"c;JUf|\Skd2:a3,ݬJXF=hŘ9vjru9vToM #sc Bٷ]&hO\ B(x2'8j@Q޼ٴk,(HXEizv*) r)1ZړLq9%#RNs\^jP1[e]j֧:-]f1RvA QiF*I[ϥr~^NY[Lש*Vj /^+ Yk0a(rǭJR4$FWoAH!VYv ԟ]^I aDaB(^g[nq[LQ iw}Dr9ej1in1=!eӌ-EiS+Hg_ɖ1s 󔭡@6ܲk׽؂Z/6/6= >@eZ3w`+8qQ8=С0:Z4 FՐHH'D.\f)^{T@Z) Xp2BgPf(*ޕ;ۧi˘1>rѵ]K]ׯyZ5|+Kϰ]C~j6`6˫i6nA0- C7zBMB>tukl<_h{Ic0->Vl|h`TJJD@>ZB$ @> D>pmJFDF*"Qhؠ @a6uD>Xf$"h$R((((((((((hDN$&*(*)(jkHC No,ZB}c.SB˫ IeNjU]dUu,y8%~gk!XӶϝW뱕jvA8).1yw.9bm(#" /b,T1toM\vTRC΍(,Z9ǣ@x`孻Z6 g+SjIWZ&N,޲m@Ͻ͟YZX6(6{E25fe9̌D*)c\+{RMg:z'RJxó:z a44Vj|T\+\"҄Ǝg$$8ͱ̆,r6R[jtJj!+"QtDZKֳ ?C:.0cdX/ BQwwQgweP,+Qm^k' jD㌳uL|CǶ,ˠ~kN2I.ȉѓBbUH2kedڡٚaOuƖ=M*F6u6vE*2lEXpDCjSyN^t]Ck垼EAшP ^fNs<' +ַt];):qя'5mLUe^1X\G+ht3|4ĩCνurJ2ZJTb} -5qb׃>n- 떒Q}Z֐BmҮ2{ff;|Gq`vRH*xr`du֔HP j0I)4Jװb4pGPS~V >B4V* Akver9;+{(l8z,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???+\T+$=?M@@WD@?ܠ?ܠ?ܐ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superpositionPNG  IHDRcdIDATxw|TUǿwfHBRTVeyu߀ e!ZaE#*"(b"meEyA @@<ϝ$ ɄIO=sϽ9y1!% |!Fx"o؂=i@ 3sPAd?f́F@е@[] 08~wYW?x %b 2ǁOnO4ow]|u1m rgZ Y@8vpʼnijdH}/7rb\MX[=π Y?ᖪmgl øցoY>:-PF89 bl4<#Gz6 9b6Tl9?ΟE.$6H^bbпUx< r<]`(5vPK'?P]|i]IzK3](8:|*T'1d}}PSXwǧ:GAYg}~ 04m#LADEq|`3h iK# Owms%vceT'sۥ 5¹6y(ߴ&% R5% 5v~zϱl?W,GM*|vV&6:lfGFSw-` %~W8oX&k2@ 7X7P½  }۳Q;X<3toxbr Pff$=D*i ǥwsghB GuHφ7e ./phi#gO.llPݷcUR+qM7#vzd1j+KGe+B5x2fV#UeOPu~y> aiDyMr@ \o0q]E%?cߊrz&Pm , XEP+k|T*ALǃ*>Q=Gsչ*KvQ_4NEKy ,aTepwꮜp-Pn@+XN1aN|<(}ߡ$i: `,gGbNhGP(<*ak?B阽ʥx'O)TZ Pmj@K J8ٝ!yf~~=ˀhe=FxOUI RgCj2[E80s#@Lt?M^2/tښ^'˾R8"|;qY%R u YQF~vf(xoG &E!s' bJQ .jؼǭJMxo-P9YheWIP2@eWyCx@[Y)R_G=ڜB2\FL":qX2QpjQ2+fXRZUX!|g2jQ PҪ͎qW~љOg.ĐNoqbx⁙@븱%'vϗaC@ cv|CŐD "ʑNsUJLS(x0CX9ipy m#~*}'q|HcƹY4^ y|~lSC]~ +}*hڼ9%6/(&;٠hP9 ?FxxgW&`XZxU ݵ4Z -'fYէl(5 QR;(9T@2p n=%y,ZM Tk}6AE5IIu>s1>!8+r O@oKj-hCGI E~0/n;tLV?`d9bnDeT b/3 *7 Dh ;(AI= 94q @Ny $ jMm پÇތbD(S]O!Zלg?| ĵgѹ]`"U+3ݟ[fM 05Ba:F]yϺ lh5+41Z*uH$\zod9lKEK*|)bֽWߎɛxz5f.b!`NjMQ~gI@qX%ʑbHr PAh ^zds<>sQ$8BkJN$3.t>=db1j`[ |Sp :tMe $FUK .ߑ0ēc!B L#ܪ,@cڷI|C 9 ]!Qbnek, Vʮu ʺRMӁDHS,G~75J-Q_z; a QosJzWmpK@70Q1QƐ{&/5ןW]z_py#z>QGc[c!M4ś $StNDHE3DfEEI HA |.s ClJD/#[9y +ߓ9r‡zf\T}c~B , ߢ x*"`p^.8yc[ a&*BQ.U(\ CGpŽdŨ>t9<\Aa!nsz<_ `~Zȇ"܄ړzn/mUk땃E7*E>(۱1@ ii;M톋%_Ѯ)fZbsV-u1\cMsk;r һm Ð@dŢƢɞAӼoؽ@dza8S{u|Dj 6' ɪ7\A(A*&7 g–4KLe{G|{ɤ$)l{~eEb.֭$܆&'ρ2 >招~m洕JV3Q+d: jVsgٰ_I*J7w.w,"djaC8hܹ1?y39BW``(ūׯ>v0 (KJv&Y;Zy֮˷^ \t4rz*%rt=QqӵMeoTT:} GHC~2^~d'^AdnmӷzPBr2>7t0{%3m@Ì,PBEUgBxY΁6jqKZ:{*.@mI$O RŸNeyi _[3@p@1hFq *#Q|[=S4o!V(9r+7Rul܏VX dg {숚W\ <٤e:Dǚ-vx/,J !C<zJi GnHAwB`tgcgܐtyQQk2yp2s:Bse^\"EЉL&c,_`X[(J ZRRZBiz= U\X*RiP Ty=k  b㸃]{wQ\\ z_GGgQ-y[K69 TFDHq03om`b-,tjsp-#5Bx70 Ωeǜ\B6[p'Tل? ܑI߳4 $O4ATuƍ9٩ءRUD73x1-sZWaŕ:b x= E# pm"PcmՊ=͚޾ISC3Vv~ts&tgP'hXm@}Đձ#IU d%.ViơBgx3*ū5U\g^xZ%tm^5 kg B)vKhjo}\ÃCk0Jx4pURfܠio^̀U"'@8P7<4@НAW6՗ymكnq["'@6R}QhN#+" Ƃ. o{!޷(B<B{oI D cD'!-蒾 &ra"xνŽjv,tӍ49#[D'Cq{AwLF9 ᇈx؟Axr0mb1%&0G.rߜ öE-a% q+C#N#pPgSKJނ SKIBz B B<4`C`@8!~ԑyAr!@09؃8O BػQa@p!h^Dxj)%?Aӄ= x 䱄"'y"oD'!޹V0tIENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFXYF6R{)([ixUwtѳY/Xӟ͂b8>FHkI!r!=FB^ @FyʝyLJ[LJ]Ե[qou7iY>+0+>;g>z; Z-]Λ笔Bm\k >XL0FTaШ F .׬84' yٓeyI MӏKΰB$u{01fy[Z}ijNUgWiɅX]$֜u1.j_cluN*NQm)k .:2tїM2^UÚ+jEؚCCa60IZFΖ.[bgoj3Ӳ&kv ou^ڄݶ4g)-tiZh'y9 <0 t&I wV6+{1jl%-nB<ܺ>g{*%ںD)vӥsПf]:f[k>]8 .RIK&X^UYdBPK)bRj6̈́]nAJQrJ*s|d1tmk:0z١lJUuH鑵:roN6iD% z])1,]jkk/6KjXV$ Z^ͷK-Z/B2ģl#' eF&ˆA8̌Lj`EaQEQEB"((((0(Z!LAB' ȉa2Z}҂1QB|IE\VzipdJ$gGO!RL6Ɔ9C-ܵ)YDZ׈xxhߢ;=){Xk>!MiY@7e )̟F"[G@>1vݚ:ͥ`\Lrca#.[/wX\%*^~˲Wu^ nYt5yQ4(FϮo>DHPF @^#e=ICZُuZ 9"Ap\#c|DJZ4Zί2 Zp@V'T-cv~͗TX,L@/tb]jG9S9֌s!3ݏJqnRZ@ -[#7۽f.+4\j:3 ao E._[I${n @cYfG[)F&;-i6#L?%$l^8U[pWY[Nk;JYT>Z=lW@@ $aX,bK iJӏ:i_,*iYZ; o*yԋfRsDNeJʐ+j\fG^f7叽֛0]'SXrvϝ*ݿ:,Z]f*[%&:U}K#BYVn^S,ttBQVpE8<(B0]s队%zKB> 5Ӣ ZagD-5cc@oAuͶe0NKA|[srĆ,0vWUrNRu;oz^8(\t[3Qս=QZ@B5Eҝwsz4Y=/:4w$.d``@|  a*AQ` pPZ\BB HƈJ G  Tˊ Drp2 \A0 p@x"(((( T@Z#@ P$D!h`A (EJQHhNB8JJ(Dᰘ5*1:Yq(P5 Id&} ku*=JuamR04h4 ڟIXKr*-Խ6Qa&nfWaQI$NQ K 2SR`ϑŢ n, :TN9Kv9mvOe;.g/ks24.,^MlLVb}yvJcuy0 @l afu5XaPꉠ@|İ|%je16d3;6bK[u@|4u )m]ЍtVJ kF#&pn2&zϤTۥ%zYQ`!xbve4u/r9)zMk4Jj:;!p Epx.n:%5Gt^$  +'@wE UU함8I3G() P::GEkx8,Իj#ڎeK9[e`z,эm8c uRPQYZ7Zcך;:m7ֵ PshwA[c .dit:x0\ #<,ʣ`p$ .|57%=f9JR{GN3LݛZ{T8q2-=oeQPDyǢZԪ+Lh{5ǭVtzvv3u)Ω(kkSaKeaGJ U D{z:R;k4_NW1Ez` t`a}mV4ʹkA]%)&X`4 1ݭa+_qO43 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MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@??+1TYFAfffL?p}0+3Q7HAfff333?p}2?$??H`P!xP@?S?S?S??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1U.PNG  IHDRc 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Ϻ}29xdz4F_H;Fc?8M1bi,iA9:`F~ד2)%B׆IR$Iy<;NOO+Df} RA0`ΚS@gag 8!dLXN!bOa {/Tα1|~oUK.OOv͂ e{*"HO?ݴsYy!XjEAGISd&?4msLRZ.i"I.AU4` cI:!س{w-˲0 d2I"```zzzGw>ovrٛH$:)62n EQQUmRn ;-ƚ%|BH@ d 9PL? 3@vUJJ/Nw:4ՋG}& vJ4T/H.7_:Ur%w9yc qֵt: MFKT͇S=LVn^ݩԔ/|>`/̆ W΅=ЬM'?S?BJ"Jp}tQEQ'3=^oj %9ur+g|y$RpNXdׁWqKh}ax OOãz)R%,%"_҂`"sO"5`vI©Tc늾x1x0$OCX-brB(ށ.|2K=_ģf$R}wֵn0Jcgz'a#*CU5t涞(f~~ JUj}A i=^ET}<^,t2I&m`TQژu'7@i+=I44o8SĂx=?$Rr(i5)S"N?#3,mtK)*k⍝ϟb})Q7IENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???<4$??7`}5@I@? a? a? a??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 24PNG  IHDRc IDATxwT?MK]XRAP&JL4ZoIx ^o{E&(Җ^3s=֙]|u9y<>U. 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(,IJba - c@s:Jsy<u;n?1یi~lM.p-qMFc<㘦۹[ c4$kwotdIcCd%gZnVn1+G%xv\ 呦\_-J{u]mƯk~NahB-|W]{`0ȶmXd , 裏RSS$O<^(=\xas"^dOl Z{k7jQ>Bi1gVTrpΩI~ܵ^h>`2zL9/t&X=/O{CODSuFp!Br1i:ۓ4T7}/;v{._|1?._~'x 3Pt[~; ;vclŋ+3f ?яz^IѣNך>.f{YfڷrK9'ܐdV8n_R@EӥtMZB2;Fz㿟hM5yՆH„~s[Cy[̚b 7oAppUW1dȐs60~xVD&Cp1S4$QNbkɉ߽~_؎X͒Uпd$k`n#Ts}j!Zŭ-5 =!$(9y{>cj;wt5TEA.Fv:"y*CLcۇzj.]eYٲ)^VE= hߞr+wq6lOvݰ? ȆIq<;P7>4F"ʇĶ-u+:^ū^ƶ-BmgGVZG]-n/>7Nn >y RWGよeRJ}H& ǎ?Gn?Y^C&pM5x9Aߢ\2 5t/ygar+ ^ -vغk˦a%fE0M k:LVLNR~uJ؆{y 'Ye,0yLJW(r&YKhhnLr\)0bT48(#>݇nw۽13SDok1JJOYi'244ECUeM3TJ(T J&P2=/ B-_ x<;Kdz~ +s'(zCf36૊ULL/8^Z߳F1. X]Tvr Wpse{ͨYO4Vϔ1slfΡSyHھg}89.QNﯴܦʳ~ݴW}i:>wըGcP^f̌u:[v ӊ7uB]su9;_zm:tPCYi9cO8E; Y^*n#zMl} $Q$)^&N iR9lV+6qCzΧ_>$HFXvur<]S tؓ)L9rʻB\4Mg2#aCm!e{!.|Nf̋WwO}=sC*/!d#9qDjWy09'^x! r5{hLpyEAqy oui}%O&3DznNxRuc`0h S4Mp5!m5-֙w3&>UguOgEpD}jHp0R+ڔ*V6 'e)?ƶEn^y_ǀQ(JSsנD vߌm[<4W>h\ٿ-]8IENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???$??&J(GP@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3_&PNG  IHDRc IDATxyxՙWvZ,[EE1 B0efs;\ I w!$BfȐ [Xblpxò,۲MVQj%ukq:u9"0(` cà1F1 cà1F1 cà1F1 cà1F1 jh¯CzDCz>6\CA0K_:[ &&tvuDC`HYt ѥG^tѨ9:RCw )AgTVK?}ݍnDF, '9\!H.;R |Νai%&3l 8zb^O6ɮ} ذa4Fo1>[a֎&X#褽H\#f!KORsגy5€K */@g^Fĉ8BƗ/DunkCJtONkcͮ$kB:_Xpn*D#Ϩai5qT+Ji/H0> "Qل$ z+7@S54\/.Ë]s[g0ARQTC1 k"'zѦaٜ`x] (?EDN/>*,c0UPMÍgidv#a7i*oo*J Y) <ŜƗrY[;ըםnAg ^f6UC)CNo$r ._3F 1 )zBp9z)a}IJI06AǐzIUլ ^#lb.,9i/DT.@h4+zcDxo$oڵkG^cHqG2x9wk׮6/Ґۺu+{0I70d*GA5;vD_j|n&ߋ.HnܸQs=I $]᐀:7||g"jjbY`[ޛg%Xek-[&Qb8̙3֭[7ͤ?(,I h"dm۶~;D͙3GzIQX.JcW#=P2ꫯw}wҟw 0`)yo߾]ZnݺU>O ~+%H3t.@O?u~޼yCWlIN P _S- 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EwX ?r29<ʉӣׁ{y `ڤ*t=H(dC2o٬"$E2dhdUpvKP/ok:ދ.*I3j% BfDFل;45BЕ]ERJ~O6zd4{kd/>jJPxK̜5CSɨ}pmm$TxW PkH%ov^vPBeMdS}"ҥ F4A8{ us+kɬ+ Dp^6z=M$2ߗT tN-kfcl9cGTӑx%LcIXq[.PUC\6{F~ifĉrE%Qi.;gInfѐ;8O!V۔V5e{c.g|uhj2d7|3| o5iCANƩvm' W&8|,Rɛg]nsYZwv=kոrmvǦNJKs?oݛn?.a$ijntu6[Kq \$-Ă S|s]nu5'ϼ`?-ď#W]5;{/$ss۟+PZ8 hOEdilYRP)O vkʕ+/;^fz'$ [? K>.MM n'eƈ6 u*f;Q1E醣]Ӡ[ EQr /ahh#W,y8rb/GNg[&&'I+t 8a\5a}םřcdgp3H ( oFeYR)O@a^6_ Lw؋8y WGO[;HsgEZB x:F{v=nYw&f:,|.m |x ۋjcw(*doQUu_-ƚ&vmW06]z}JnM"ule ef[#ӨhI:kx0ի+t2Oϧ꬗zTHGUUU;ww c58wß NGWD8T iMP }eFWors7`Dt]g! /( (++YĹ}7&}.gii(BI_^8uJJ|I 0o<,Y~cEKDmXd<SV< H$g#>C1cW@; !`R5bC 携ͽ 93@rmD ep4SLa…x<=k-.Ga YT9/TP\Y<"1VY+0{l|V>}:_ʜ(Ǖ!uRBSMSX(-ˑFHa#!n' 303*EyDf[RH6nx;VHi(?s:P4 ;AJ#ҀYʅ> @(‘{H3^H@ȸs/{xItu2.ņM[nsr܍gM.b{bî9p=i8lh]VІ bx@\_3r8q&Є wA/OKwt;XG9\N/k.=9nBkY4_]VNʊ瑝>|!ƨ4H$'D9{=93ׄb\4o^O&qz4Ohi=5Jm <[OéhhLs4@\V).4qnc k(Yqttⴻ#!a¹%:"~ g\Fvf>RwObOk]N/TTfz"͉߁|**%E,g|a>;6!EfZcjn=iaņ#'v)]2uF w=aVBk/Ha򵑞Ǖbb,q+֊a iVc5'$DG"fEGS5]i~ZN)3Jfut*Tcڄdc0$<)VcбL]ݦOOY<0fJ+3 f&9 "IqڏH)U~q:tvYNJ6 4T !l? kyi/n$)ӛ EXYz+##-s8~.*L{G{k8y`f 6DGs$I,+}<-/ sL7B4?D"9v/h odz?܌Bݕ$ǐM+2.L?l";#|ll#L#G FIxT$yM`ZV-"͕ a^3]q%8n^s #/RdԷ# x^O6^O6ng:.{Rqrik s3 Q\.T{+Ew[GTHXYS:-Οnv6NHm\yzEp|pNP(hZ4, O94'g36C8Im,y<Ӌ˙14vK#u HW,]yA)"[Hb3Fm ͕ۙe sO^w6Lx4=H0~*NG7ins-XJb%I]"f$h]fdL NyNZfsr#ݓn%ύ4wVY)RPyNZ ZÆ]sivlQ4ECQ# !3*.A!G(ڮ=xs6XbBzh6'ix8n{㡁$&lKCƳ*>AEʤ(ΟlvӑΆ@1LAD^MCP(h)bz~_e9RnGR>Mrz(j#jݓu4}z3_8aah5?HBR^<Ϙ7 ٖd#;uTE?nKI3)Iy7ʋ31:RtON'r2st- N6]Q*sIyDJ;hx\4;IH7Rb1<3ݲLṴuP^<Ų"bYSvڬoKVz>>cA([Hf.vtL!;>%7G Q>an|UfVr|PF;fd tA 'ny$|l6;6eOJGG(F:Uo3u6tI+=ǕA=*My½`p~3gUMVҠQIENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@??? $??@BK=@?@.?@.?@.??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4->PNG  IHDRc IDATxw|չSK-ȶl;1%. $8@$$B p)P16Ľe[Vwvf?fv++ݝ3glEa̙l<%L( gqWxNmnA$tOq皿&{)(( ''Ӊnرc(BYY@;UUٽ#>E{dM#Nς7vf 7:SN9 $!2vQb:tk/ H}&^dfGD6^ѡ?{x9Íľ#[cl6TUEu4MC$$IBEO?*QQDeFՖ Dc;܉Udֱׁ;]QEQÄat]r%Ƀ7(QDQ䓯^z<' l6G闝sQp,ei,# ȲlB$ DQTUveI^9 P\0[fϻH4|-/X`0v#2(i 4H$b-آ^7 $;+\< hDһZcum<לw?Hʪݬޒ>cx^kƉba\.yZ+<,}vI6ղ( h@𸲹gu,m%&PYMG$AbD"0Nv=sDX^As 8n"J_H4?@8  &p!/k>g&h:JFh^VmzSg)΁@e-[*Wjq~tyϝz5J,?XO ܈?7ק'بULQ@] w,GG@S^e$5{Ak 8TUM@o0X1I6T5F8 nC:my8QT0 w.yES̩+wwj{n0n8Tw}7幽3OWMz;L;Ɨ4B;V͜rQMxwY`F[K]+<]#X}4BbI>".@N~}8>l"+?nq#xޗBvF>cݟ<'F{]EuuzHbҥ\{xGkp'ӺP=ȸٌt|PbޙH꺆 Hd#Õۙw l=RykN*=H^v@`,K(0 <] 7o㽇7# R_믡NAFVGun  ?5UDcaHtla0w\/^? \0{z~cC0-=uU#[8YD0Q%ik`Kۗ>>*aw't!;/5dzr E흇TG#B?HH CGas<ƾWaIqќ;r:NU=JMh*d硧O`>#F0|***Rpޔd]bCK'S/XK=ҭ+ӱI6$={6?яk,]adgͼy1c?ϧ))~5d$w%>dSR6HgSvaȒ I;')>x0}<,Y1 ϼIDZM7dn a6`<$+3]w1li5l"eE)-NVF}:5 ,,۱Ivz׿nz$b2w=Clt]Cb/EPdϢEp]FL]w/GQL>kn9U}pUݺS#)x5ny7{7& K.`k3S7bC|QiW"`0kVEMM o`o O>ѣG';DX e8>a&{{mde>:1}W4nxGy3΀k|--‚i;ږO>@p(ѣywOv _صkugDAybm_m}GڅѺukkhZ MS-E礈y[=^^^-yX4p gdgmNdΘYk1>J\ "W-`-uV~a^z% q&R*Ovn9>h2'IFuaC XUS]:fK}gW^yfY> ~X2VzTɞWY(s#Gj_&Mb֧O%Z/].>O  jwsh$M-iSk+ uR<CN?teeeISkNG10{ob&SpPT0)Znɬ]+/1fRObڵ>|z֬Y+B+)C'wFU53'^L;Fm'&Gx} ξ 9xN~:@  ]vY纮<+͙~bZS}3 ـx1,[f0bKp&O|N/+gWbƏcB[׶DCx+j:L:ʎkAoK׿5w=CJ[5ξYOmqWdU+< "b+ωJ4] %Li{Saرov4qƥ^˿}W~}$.Y\s O2p/1T͔Q PbQXX,`="NͶ'V7`/e J-rgML>Gcds EALP|3'_$M} +L ?յ<9SYp!,ێ2{17|36l`eWOr3w1r nsq6ִ4+t i4BUO**fscKy$yU~ԳbQ˦bk51sFqI hvu`KMvv0v,vW1A#Tz 3gʕANf_# Wm.dn ϪWSawc0@țݷ^xjZ;u4]x E("Jj;U~t/tڤh-<ms&@8 NQ"j|Gx*ekP}:~5t:ygS\>{dsA 4@t˜9$ Oh0Μt(6Gp"G'/Fb K(Ͼ7> nr|_S6Y0&zOG&X*==+W]ϬYXbEroaev:Chi~v 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(((JHD }_GbSb}/h7n;G$È'c4 %cCX EQÖHd ZBTUUג$yߠD;+[jFcbbBA%Qb 4=?:C2SRft8gƍY,VR=+$Z{M3>z31Pfa%漙6{Dxr ?Wd'Z[H$fC n+ Z6K 鎜AnZ p讔p.4i8 4qZe p؀hZ Y#"`=ck! /BDvx}n`)gil =dtb-YpҁfEZ[&uW3 =+ҳvprT!NG$Qiwya(ڹMSQuŮ,Yˑ(-=3UUظq+ƍCEHdž -xB]kRa\l!ANv>ռcVC@7u!(iEtM ع|+Zw [tZ`|u=H$%Txgݦ>dg: Qy|wҹN،;ZP/}JLAQ(JjFhXXGgiRǓ8 ᄧ<-p 94KlwN6wH14g7IB7DFέƲZpMT,c'v&0}&"Hj;>99rb/3`c7-+MlN jkOI;Ƹ31Et txNcIL=$Q6%tMT8pki[3Yj=GĞyttP^ Uf@iQsrj[ UULG ˘`'IDpsP]}EsR 4᷅qgZUtMEJ֠ij4shBhƎM4:ӕ̬jEYoo]7i9RwcxV}l*t}\>~3%BSc DPqT8{C ԑkPZ4U-gQ"OOӏм]yF(ϐcLO[,&SD]C5$]c_&Ov;[#0,l:vZ4vLtYVB8*\ p2ҶIfvA2x%;݇60yaѣ孎-+`x}67lCmfq;E|dU5~! <ǽf%t4Pӵ Cm=9u MNS!DUכ;Ң\!)#FتsI ڰc9EwXc[tڐ$ ȴ1 f o'?f $cfٟGpiaw%9~(NיPU]W{.h84]5J;ǕC~h`zz[+hȒQ!Cw(|yGX_$ o 9%֌pi7QNaԐW=u԰rQR:#l73mDAJJuR|s~NIO O6aRʡ nExJ =dF+Ӝ)bho4ٞ'xC#nEk[Q5>!@wZnsOs^ӮFSknMv K6ΚvvX_7үfntM㰻A5?cvh*_f/@@HxR&?$)ҭv 3] d ()|ݔ2A%.&ÝUy3o% GD!Zs˖0# :}MxT$o9w*vXΖQdp(oOxޝliv9}z6oanGcoVz\e[am w]Y3I6G! _nM'"c,o98n6'`.# ^|z|:PJ}q3 %e])+On$8sO,z]ר<*m*Ai Զ8w9`iGha,}Oqe-p2>}6⡕ nGl8ekVu=oH8c9|*N[&˔m:y ]3nQJ[ TQBhD;@YyƝ9+N&d+H1f1g5ZQ0by|,lFUb -maƸ݇Do49,[:= .JG:F!@e'I.">_+bR۸cv9\-rjꏐ)0@~0{Dc!$@ # #Obi`_N_``(GOap9aa (,ĸ=I7j P\0yeC f,(*Ƞ~ce!!/.g& *:1 -dWɿ^N"TU1ɶevwYG/aYdy,d\^ <7F̳X4:sN%i@+3LnvΜr)h#SSn9[ᇒ;{kށ F⛎*WD& Nߋ 1C@T2mG4^;CED]G$>Zԍ Fe;fF*nW6mk֬\0,[񻤶F6a}?Մ pm(@-+Ia;tBIr 2dr8s|N!J:ONC۴QUs3fЙVOM0bsE Ds9CA3J4MCcWs//}>rƖ$qf1]t{lW*adɎ,de,r1ìYc4(aJRBl )9?D$a f~dCQ"4V6#tt $ÙìI:MV  E (*Яp(ȔQ&Av\r%Ij) ASQۜx L}`ncHx|:2y;lA45Cɏ4k 8C T"nl{'=+ƞo( -[`"X#ߐgf,q0}MSAby౻_#p: B!kLEUchȪo}bDNG[Rr૦Y8HYN4%Ù(J!3u\ř|:z‘%Ȯk;g$,3݃atxp9܀AܴY`:N̢ ŊZ|O:m.sߔ#Q$۟`w8"C!fsz:h33$5><첓ZQnt$I$8-70b+nskwvWw?(i Ԛu4q:2{)#aO96tdqe1lv{DǧiќuʊzS)@ q8.';7%&iH&J]L(`ӦJaM$@7;>bPH Mns该_KV+-v{́ǙE~N \> sۙEa^x^G`L3Yb >v˃?j%#It].wu(GǯA ;dEp|sfN\7OPU{~).C rq܄#jSPEMC%[vK29߷%8|zbˡ#8^{<(~" jr3S~bY] ~00u׿O_+UBrmvF | TCmQjG`29n0DdɖrۅGtv76S p# Ƀt' S?pOLbQqR;W0>Zm;=G؊_Mv`h?%j`ǾMg I yȳ*VC:ĠmA:]2f?%}-`*vV‘ P%Uڋʦ:dHpq|79#GK)yٜ6Ya]fn5de#@۞tH̗1h*K>321bxYvώ ѽ#izju;aQ\pYtxWq&} ) 8a!*BDVnxSfe,0filٱq#f˗i*WVl 'Uoga8mmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???QI$??+VDXG@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 50PNG  IHDRc IDATxy}?utL3ь m @ ،eCx c'9c;~9~Kbǎ1lb%A,B F4fF^Uqg/Qխ[ߺw(o qL2F#P]k'he=>/ħLɯS&ϟ0":*a* i3IKֿ^xapI%,i8FzI 6hS.mX3E,1HLj%L b}$S1a,dqYyF9j6CPej93L!8̧6p}ESyަ,dEQ&C>#L;éKΝve10|xrH4.=oZm[eP]H"J8||㩂+ a|z]ӧ* p=nPDSu4U#cym1)c A" 9Ne*_, ףo0CU5E) eQueQ>&|>aԡ8m۶y7{6Q&@Qܹ4 MӼd&%b~Ҳ3PPFqBP;y%V[[ۄᑂjmY` 6Bd M#ڹd KPP$(( 'g=gtvcK{¶Ͳ,oPWWWH2=[8C軖Gq 9I]3Ώ5rI6mc%;27M9D{p,e'y5('wԱ, ȟ\ Ee?-$P<9Jr YLGwb`:( fIJ-`tA}t͗mkJ⸰,+Oh\0hiSoTP!G3~ @I<Ŋf8)Gٽ۸}R{L O-,c6z;GK)omOVPqw25RнN?),EQdXa,+e[ضMvT M34gT|9cLBu<ޛ-42ضUb17KT~N'IOEeV08;~*C~_`I_|?sA25}$P;]oi欳b?V6oU7&z6L+C:$N?Yqc} ao_/~ܘ"&+wt]U`۶mlܸqTOo q$yj"X-l,;HߌV_ܺ(ʘ7%c1I`0'$L&] d8~T:^;'c6maZw>i ҙ$tt&I"1*3T" @"*G.`$10ā<Gn1+|ٱv_Lnycx=,*7eضU+8@ǓóN8Id|o~il[σ\}ϜַK8rdMJCgU|RR# Is3!HEIڪ U {}Shuu|]*0BhM7.;vK8rƃ%Hbd:F: 5/-_u+8iK `2fJX8. z',TeOai4(~{Qyce$2!\%H$_Gk2µtGLK1SЛcqn \s.kW-[ͮ]! cQPE`jz}'X?a~ z5!u01<<-B4gȑ#qG4㱞??_vYR T*@:ᷟ'ʕ+8xtT#={KzwJ%`q$BnQ6t 4z"Çb1^;<4M#R[[˭_bAIU9p7qla#lGOӨJww7ҧա(*ǎF%@"J&XQ`ik@ÊOkyf~zհW-\{ӺO]QgG"׏!c9hN}APw:馛/Ov%mg,G6\Qda#UD,;3nL[[M9gk֜OAD==\pCNgw&4Y '4t\:Y<ȍ߀j|;ⳟ,vem6nUz%_sQ.]JSSt;w|r(;tӁJ3K%.ěYf{Sek9SOmaNĀB `?ď1 N kr /_j{xÂ+txƼsI +Ώ׾Ɨ}(oޚ'܆Q(-weu4MLoFEMYlذA|[׽smI`)~WX4.,S!g= ć@T`믿~ i^{xٿv}U|Z.ק@<56o,nAtꪫħ@| l"l". ]"/Nxlba˩b³=+gOK׈y+ż%nh]Pps>m}8ԗ_O*tvv/Rp?~@޷UUG 5B΂ UUiii]z?ǵ`_tE<#c_}ߡk>t৿qTH=qκ+hQޯtbq۩NU}0!Iccoww c&üJK._v)cW\ѣGٳ /1Aa|韃zl? ;vW^ᓫW}a~|@` p=*t,l9P L*/5ʦ:Qyi"Ҡn$t qբ`a nM39q?/ǟ%LL p7suܱ8m}-` c15JVƚl;UAwcH :9|{궀烏}JEgϞ=쳄ӃBT/GApqtuē 'ZHmtW]{fY( pκ@~]cI=T;ڀ"wh<lDAcM b֭9r^xa̱իW+x6^B^zkEQj#󨋶PGf+Aڡ끂vq+QPP߸[dؾ>M4\IƍP$3,_P5B`/4M{)UD=J Ӹ /lzf|FHP-uV[~}c+M7K6J'He23em14~Ru2jZz^3ŜL[OĨ0}ϣ|*ŋ/g׮]:tho3e6GS,=]c&aph lEt|E)(#趉m[8B i*-]~}(BTUa$>TxY'Ҷ ʚe2t}bh=O!۷RPFpq/lY/f7ɉ %T맡K6'}|>tC<zTjY'(|iq(9y7@UTc}G_@\yP;Ή>ٰ|wex >R1Ӻ޽{馛x'hk>SGIv JWkmxjxrή#h?#p0pH$B4Igqm{+Eh󻩬$XQg%VKR`0- Lֆe,qܙR8ݴ.a>3MCvW^rCw?Nsbl۔M[Pxm_ajNG[JbN[E ^voӱo]5-lmwMi{֗N&!H03y.B5FWH+vZ^|n7( mx{,bWx wHś>Cl~>k4zpRU"3;Ei[IgFKb_~%uVUv zms?ܽHXδ\~{TÄ*"TW62=SkG*\35Ok;Z*mID./kͿ|/k:lO~5 .w8%HĔWyV/LW~9K܎ eד [̵Ecr>mG*S:mvVnލf22{1]DNm ۶J6-O+GMRnYb ~ƴlrM{ꇀ0g[,%OkQq[v$LHVq4 eEsYDQi:LWĜާnIF&,ږf&HeK:$Ix1h#Zn?BSu[UyD)& {C&%Il?gTBHH8)k 'q -ڂŭX<[ )4S$RĒCT$H ҙ;veil2;40u$k6JN蟳4ie5Ug(ևhQ< /.]0)x7Y!5ޙBO0!k-PZׂ#;U lXT:ie$R#±֏G0oC J'v>͡樠igiz+ؖʫcїY־UUI^A1ށڋ&k&)Fz Y0CqfQE۹Lki+ZYBpJMj4L\w 9OO H LŦUOkӚ3) I8ig\C\t懽s "OMUU:L+Cg>1?Qrnj7J8rGWYJێ d_%4yto?7:NrMॽaM$cH Xm\tGfM9Iʠk:>O?Ƕ~ bڪj¶-2fʩ`'ѯz~Z_PD+d:)*z% 5sN)ˑv UhiSZ\2.پw|/( 1IUBD 1,^{I Uhh04[dlOh@ST|=_,a !>'ITV4-k&b҆mM+ O%쵅{vSr* RqȓL''dLirށ7/AY ȲM/L/DٙpGwr^J۶Q[(ض=WDJuPP75K2JaFkmsU|y .NYtȎ.qN wrYɛߤU7)c=3yg<1 ᬰ<9gPޏxL+i[NY:Kgڸ t*[ B~]![Le,ga˩u\dFseQJIC+ ) <ܯ&%ܘ7ͫd0@i}ALܩUoWik]7MzL.#y|Fx{~MX60?]b;])3Oگ8JRv T@jt~cJvuc=\c<8IDH 3RLFJ퉅-k>!\Er?g .Ɤur}rJ6rضūྦྷoed> wk ˄6a9S!IHT&shC^c.slQBvENP6@z,+#GN"rc8"<}\,p/}]=d Ӆ6Lf2I2V+/e'mM+iKnuVo΍d:Eg3tL Y9ރәT' #qCs4M9U'@z γ0L3ͦ_}O [( M+g< d=%‘%9U+%y(twÐsVA$\tt݇if(Ֆ3?eˊ.L3ELs;k2*diwwcGOKpީY2Uiٗ[ka (8䊯T:P\uWy1ZTqYl(UZ9ښWfobmĠ\U3)%˘Q(>ꪦ;4LcB  6En!Mu WžTW51q!ufW( yɎѝo;=ݦ.ٽMxrnOזK4.kswS_=p0V !p 6~uɮW]gfЬq_Y8-n]–5s]/ҨgCM5mURm)n@CB\I @?, P,d/k>L+]T#Tj',[q6iU]>?6gvLM'rg Va_,7[X xnSۋ< =*_104,3='~\rɴҴ4,mU^\=<ò'tcȘ VdȤӤiϟ$ւyF "~wDqɦ蚮ȶ-RČӓ{f0t۟+y:R6²>w)LXt /Gw躎i,4c,P( }=ZejW99c!f +u =0'{a5%"=(FVTݷ dB|c[FQ|#hLߛ1134]tiɆEIHn04B!l6MX0άqk-\rlj%Ax~{MMu lv<]ui;m,j]$S1{ &no[q'M]Ǜ-OKi sɽ9ulVL,K%ָāi~)f`ZF'EҰ,; 'J OR/Ϩ ]h\PUg$q Y(]ͮ{H]b(jt?aihZ7*:kk: ˈT >I dFN6g<UV[J2 ͇蚎hg_' oxlD}ʌ|F 'Bԍ,OhV8عh-w19 DAāiG P]"܍ifh̴S];7_K*kB+sK,&V"Fe 7݇lu]Kj.Xiz;v :sxQUwﳢls 4){&IރٹG.Ƕ--Ќk8,#Aj"MDO1Yoie5_΂}fXS8[iB4T š&҄XQT!Y{%{_MӽelR$[ PW"-s&Tg^شf+`Xb@`*^p|l2T3sh]@"j5-K4-"c[4@s"[U'2WPեffBs]_ס**ZjV&Jͣߦ#z  Tҕ㷜_b@7dEUh6&ip+4r3W#d4U)ds-YJ~nz8>-$<*5ToaFך.od0 kV_")$L< -0*4UA3~e( FaY&>]g³qbb"QPXҶ!o=.Dn\(O4=w{~ lBrr=<v*C5T|痟3+\s A|>ԩ6|Yv}*gV6RQFIscaN[y1Y]8ez8|Ek`m^TEe׾gpWMUu'qAQu i]H$\'#}՘2dO8kJBPHޏ;53l2 7pD"W4 m 7w5R9n & H2LZVd}o/a8]ݏ9D۪*k &,( WٻD"TUUN_t:M2oyTYFIENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???$??$?`fC@I@?@"?@"?@"??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6(PNG  IHDRc IDATxyU{Ͼ0,l Q6eqb4'. Q&pOLrI>7ףKFMr9\b܃& Ȉ *"(0,23>[U珷{gF>* ,Ҁz/ //"mdɓEȒ'%Oi#K,F#G7';}#{?Jٰa}gGhS/r>P:QSˠxl_47(*1go~s{GJ 4745M( ʇ[T EQh 7g yh "jZX8O;܄@4, Ýotq%yl8_Hi [>Umx#q {eHG7. "L4 TMlI.TW2(WEAB-ǵ':*+k/1W?Nge*s|質-߹ZMA3m=o=&_ː!Cpr˲c.'43~O1c'Ya,Y2-[q㍳2v?06OPU%֝k9u<5p0 @y4d"Pl?A:ܓ2e8;vFUn^o1|x'PLKK(MMa"0;8x_S\~),z#/^C/R\wu~0- 6pu@_\(=@[[O=Y;`ۻ+{T L3a~)"c^s5<80a!]t4vsov ,e'ʞA7m -J!"(cq4`B:Geeknb`OgJW`ҭ0!X8>H[j]NEaguR *3TUUziTy>u-Dbu1^{<3Ų5r<zAj3 in‘Vn {u gi/:9w/ccPyJ i 5Z%GۈDEZ[h 7Q&Τq3[.m)˖q>+Rq8꺊p<I} GaX߉D# Y`]{,͋#'' ލ= X1ͦl[G[oM޸lq'|r:(*JzFmm-3ΚTS.v$J*֗~`iߣF` !48iM-rjCF# |D9@?NQd&NU9u={^RPBL|0LG"1=(˪-y&M}!,L (@mAΟU>s$Om+/ sJUG" 圳..eZ"tAwkgRn/..mHHni:;m0¼2 rJ rQ WL)<.Ok0m֡ˆK5(墙7ifyN䞣$[i CcK 9Bjm e1IF &HGd> rIon8uuu)CFvyԠ(H 5渑(-(o(9CrpַQ?H wsƤ F#F q5ej01 O[݌<$W8'ONPr-%s|[=-H/s("QV63󨮩fm֔%ǔXО8HV#ߟ:/vSV4uFS]ALiMLvU}H)Ja^A>i'Υ՗NssM͍z UhKЬg%BUQ((Ou G!Aad;q\M(ٳw'1#رcdH'=ʊF*0B]U7{hWma'm92k̻_xٿ9\}Y;|x^|^(3iCsRAM}51 ]nS*>2=DN aJuS+Dc! @ u"ʇΣ$;w.︃9sp͆ ~DŽ Hyw1b#F^z)>{ZZGY/ Y7}V|[Iq<} [2~SN<ތi~HoF ]Y`}?5HkŠ@)f>X.D=g n&Wxn#k PVOΪU8pmye>{>;: HPQ=4RČ64Mr[?h40eʍV?J?>ۍiaUYYISS?jmsbLJSs#E̟y% l9tc[uk^qK.>RI^ʊG(CΜxQ\Xх95{y}D>^vb @ubzX4:0 ߑh*\yi{Am?>?Bjt3JSsE~/>ǴhmmeŊnR}3N9^bݼb<.gB)iK8Fu@͕aT)7o/СCl޼>ލ[<*uMweţ 0cead@UVWƟ^riOsYmIN޳>b{ cYWXpaJpo,$qD4aPw)u¸n(? [n2޽UVq饗r7gHBEFr(k&^J7LhX[s/GMM5Շ05+yG"w>KE^ f͚EEEE6 =ִ̻e/\0~ۋ r3|]nxn:5@o|;vओN};ő8v^)\s>VqSg9aؤ>D|몟Y<d~X\Y? =TUZνh"^}դmn.`frgoeɏn -!"y5(S]uˣ7<̞=wx }-tlE[lUı3tL[$wٹ臄aW⚇yGjqߥ<.#ČzEQ hWq4N?7x^x7|{ｗb 3ۧM?7l zDV$_pԩ=uoVkh"Zןb߾}l߾իWs}.:=^[:8Q‘VΟd)Q'ގTlj99v~W_gI]]vK.ᅪ*| HM8pV%\a6Yp!m>,\u HM]YX.cd倔@JS.'i%k墙6;H8c đ‘Iۅ*; qFƌuZtRN>d,Yƒ>`2)U |ң^hQ1—SO d$VK;U4:\.C2t=14C镸]JQ2|8$ۂS9+W~M7HkafUגrx砦_}k"Wdx>.n77o_nD%bK)az" u皾I; CڃL ;\7عs'˖-s[RUr??R)K`ۃ]qw|8I͓ω0_<ֳ--AxOe<@7"aE)-m釳ػ\0 :]G,c'`N=a\^TU6\4\<&Zhmk nG?l~OE@`Chө)yF72g;< xcץ|z)<k׮P(?~< Lx<~#ɶL)=+TVli?5vYO|ho8a$G;b MϤ=W\gWW|rLD4o2Pmڴi9O>* F}ۏ-Kι4 вé.4b?4ux>]à&OB"f#MR7r*?ho0k,~qRQQ}իykgfzH!QZXzd\URSe5x_"I0:tV߆ Nɗ***|TTTpwwX_/_^Șa /b;".[ z' t$NUg'O_{po[ߛc#5T(!acВ륪j)%ı3VmXJa:{*//qն4'$a-Dt`/Ij*3eٲQ?T7o3>̝;^J6=sLcYr%o/2w}7+V0~DEjJ )۽mGMa3bJp}O2p2Td;_;6LCf :ܹsQU'2w\JJJ8پ};:?я:?@6m[a()(VڡcGv)}`3B'j҇#M:#?;.}"HUV׀_Ϝ9s(**Gq hd{PW"T!'XЬhJ[35&E+JQ!ϨapY%5;ίXvoS+^;:N=cyb%z pN9G´R F _E\〓gxx=~iR5.c:ʠTj7#/cZ>w oߑ(DS4ل-┙[i˴:6 !Pa`\4o11 fU\MWvF'i[$)iu 2<Ɖ!7;5t{u8yBxKD:gcrxC{q}HۄBNcuv=-1VKmaene:|*++'&VZUXqI[{?yv2Y\ ҵ#pNZanĘ5 ~ʭBIDATqT!ţOdY\|/g&V S=&_Cnf Ð;u=>>]Q1Vt1K7'{K5F|2uYOQY;6pݾ8il;pG l[_VTV8}<s& bN-ܚ?/:m՛aZ6 1`KEi d:ĵcvmBe//m}s+8.Tn ܔT!OA[P B_2"s>KۏAAA7cN^P? !L,y;k9!IAJߤd<~_.eljB}e 7HN@>*)0+#,hj~^ Q֦n[|ת 'N ɐ2GRKSEZQS.qT- m&S9BmWձGRVeI̡OӖ.LӠ%~0o(^7NJg ^dÇGcOuzm\n45A߱>Ū :&}j*񥡢ҙ%H_Si. Lyc20o(i֭Nx>?; MQ>Vg W/'eMUU}i{P:N)dgAۇnDc00O~oKƠ(*O8'Ny*mO['QTo_L;BYh\‘VUG;JϫxOqNH՚:c|NRNǏߛK^` yE<> S_5Șci.TmnxِR >9V5nG[p&G `w 9JmcKM?ux+E'+H=;)0 PعCxiWhRhnԩ{)'B~{^:KyFJQ%&cÉYjev\V-"W9K9bIBYH|yaS_GUw[H D(9zO?G2xB #ƻ]HQD?44Ww9Nq0JjBlZV4:krh\bk~6)$!mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???og$??@.Q@MbB@?`EX?`EX?`EX??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 70PNG  IHDRc IDATxw|\ՙ;}4r{/cC7@B }!76C6 ˆdI5i {dKlIVryw43~gFw==g*PQ EQyoK^!s?Tn7Z'FR1E1P뜏-$4':۩;1=,$& Xr簤Koz8?Gژ?@ -/9!H-ZEQ^6z.*cX: wG&ډZ%:0-)-iaYԱ\#!':'dL@7F˾"TEAUMUl %)% ٲ [_>I1q|FONzC6ꛪ,k+G)'9gAe88VIQ$!@:LSL=MՐ4 ,qebZ&XRv#)ynfLt7 TPD H Bٴr*&!SKހ ! 4/G[S iI$Ha;{]M D7wX!Tl\ɖ ږnQhg%Ҷ%MTECJIQnE:KH"Lj%ٽgXb GR6 ؎aH,U|͟Ő mH4ʌ `:cZ3*3nnK/Dc4_>k6L&cQ 8)M%M-i[f2,Wpd0:1lZ`K{Hl(&VҒ yO x, ˲0-!$0 LĴ L-p2jtŰG*BZ;I1&=s'YaX~H,ˤ6fTMcK]F[it&˒Uk37~+NG(f]=Fö46;z?oEi:}L²:LITOA(*^X?ʿ7^=$g_͙3dԀB(J?dһz]c4(m6q $ଙK3귢kAQ 87+9vO'(8Za,,p&vX+VfM>=>l&@7- S癗LV8+:2P@@}c5\zyi}:Ami;r%%e%S(-Oݑ)5GX+>o%+Gv8i,YZlۻvB(6MMl641gʅ?#Vz`OB{P !h<UaJmnPZ,ӯHwϤ=L,W6an[=nSBAS=teY&TuOTŞ^7V#d톗1 KݚRO7`[h=4H UUS2ûl(~Ya;̘I$k-VQ7ڵI44A441kyMw'*7;H~m=ڌ!&]'Ng]J(M$bݖWm AU<4XIiA%3UQy? 16ip6/%s#$[B@e{H,$%͔J1"?2֥t;Nhظ>n@8P1$i4UC*.`$kqU@(M)y'ij9@N$زi;6W=!&;\2MCzUOכy٥9Dlz>oǏh)pO=3L(Ecρ Dz,vtNLK *P1#aIQŴL]%- ʊǣy{=.<ѡ7b6xۛxХj*D}cu5ՃjKzP;H,np(ܬbΛcKSj{[sPbY&G֒U̙3j}# Btw2@ sEЗii<E9e$^.DJ ә0wڋ̜i2r6%c1 ]g)t˖M(irEΞsmq8q` B(Q[dy46qq/ =gemF sg 7U]>ӱKIcA6zs6|Qqoiezh.hΓihZjsE7CmOj9ԑHӘ@6~oE(de^t#XGf΅ nP/YZJ'TD*,ːM-ɣH1@ѷ>1yz#aЍX .<.BEdvVu,;Ki I:{hHہ|d kq=M6r-es]屾h27P-oNt=-.ɨݏn̛rqZ]~NW ԴL ˠ01a%;<=36n&Eex4[NQU=a{F~g|5J$#"K9IC$cI4T&FJl8yyd<_jcds%DbYUx<^<EDQ E6y,n}i]zmxhfsB<,&KkGY<E%7Rf8d$˖bO ) ^-Ţx<;/iu,;*QP}h ϗ/gٲeҕ4j03 5E%@Ped|oH+([qEjѥS,ýjҶ<+X/YzlݺI.DI<Аr8rTѤ^#|]*ÅtLt~ߟ2v#ǔN%ey$Y^4QM*>:,?>, aQ)G|? }aǀܰ3E#|~˹Oo:ԉ]Yɚ*3g\J`8[n:ϟZ# 'Ǿwy/IͲ,"sYqcIG]hio +"T~ ]W_݊ L'9E\geRR"صkn~[lGyv ~Ov{> d:A9!cJ9n(Y9oG~?=ζx9R ;쳡n11eܙ2ǩ5NZ_>R#vt~ #]\p/}x<?_*||Ǻ}7ym'O(e|,:{qOZWPGjqugڧ\~qĦHGBHUڲ""%[=u! i͇ʡ,>sax}ذ&M⮻ॗ^n+tp͎n٣FCsmZ FJ8I$ `ҙJ_L е}v&OΠ`EfͲ͚5Nm(Swrv4MNVG?``Ŋ=J$ 5ydy睔_bE7KIғX]ӛ8ZC2 KA 9}$5Xy1-c/j*. \y,[ $8#肅3gN_"ϜD9}IZN/̍ȱeӝ)^2'Hdp t__r?rFdܬ"R?DQTpÏ9|[yD"$ v${Ȟ={Bj*߾oI 1c9N`%EE/ Kiu43oNNo=P 7<555TT؁i-J'xn} @jw @ysZB}u[?q q lX[4Ճzug 3i-؊b ;\0$%1=]3Bjw]w-}}y Pz]vE a :&N L`:wIK{M-nkeS-L7d }OǷu}Sk.2 +z>p)T[Iqt3nh7^Ur#%NGGBӫjSWY3r)$ѿѶ:]y!g^s5_}z=q[4О6ӽ:`)9c k6 _} ,&4b0g҅o!q݈qp0!C ;|KF0О)H7m03xcr^]:,L~»,K{n\Hi=h+ \E3=×xav:MӀ׫ְ^c㎧텿}C,qґ䗶$%CT\~pNU4T$i$H阜is'40-#t݈єA;}8 FE7-iZ:[vE ÈV C "jNB:;]:,@=|-y%k6v\ 'jjje͚ԲP?|^.ph"oI_S|H 5h#͵mg\L4K$Ǩ]Qa[,:w$hk+ g:3_!\OvxbrSܛo>`=FS+1u"yt#i ywß8ce44QWAvꬶv|$3$]~c:q &SBv "ݼX5gO:p!ODij9!߾pBZm4,@4߆iy7ٳ0N@1-);/0u9I涘3 lmι*MpuqX~lHS#̝r1nK-rޔ IqZihcJAvۏvgy0応um{?uOXE!gn,O{=WĜbFؖG񨬘kk۱qe38s&_l rO^M4Cݑ=^KS"ϼgq7PQ)FU=7P?&c Z/^>`y쳬w|zhkKd\jF$20xiGJ#]o"WY1?n$8Ը=͂ ~Cκ$%-m pA 8aSnfJ]XJp;8ܮYOan@6z?wY(Bp^TՃ"33 bYG;PrEuS2S;w.a~-ͳ&)^*v Dq޹dtѧ7t֬ehpU_c۞KpPًv4RSRvCB~)^))òlwrz"i}LirͅhDJ[JW$8wΒs>?\m_P!׶&ym?FGVC7bz%Dӌ Rv;OjL-|I'ysʜNjUzjs_d9wP^4~t%i1TECub}֧=LUz.[|;iUDfMx"Շ_Mzoj9Dj^ɎL>Կ8\S;HiYn( EGҙ.PUih#L}EqĶmUUi4u*G?:0Mų{JH Dq>w?弔{rj%jڣV%MR z?bY&vź-Nn(ERUGʘ5|goqʳ۾ԢE}IV dw;\ }a.N|%%-f?ڂQ9F㷾-TUŲ, 4Mt]GJA4e( l۳.vhhyy @ܹpgZ[ܹΞƖ'\GHRi(a"uIN<'Qz~?d$c=H_ b \G[s^O8CV0!^Ļw+觥 |aTU1Mګ5舵t_O8v^s׋%F<'H$WQ5{kDU)mmgCJQuP 呖#l/4}C]PJI{{;ǵ8 b|>4MsWaDh4JCC,Gy6&T%7FϠ(e囏K^YYe۷Kbڴi# vG*E:ə6TSNL(H҂(m~$y'iV0xwAZg!/HE| ,Krv[_2l2/_l–-jʔ)}S  #|B#' /L( ǕDR0 z Aw(i=?ܫW^Kd*>o?Bv8p(P0BvV~_=a`[n:㔻蠱[ZZ':zY]kҘ3h^<7H( #fO)csQ8@f򻬖$3e Ye*>iju `ŊU7~oR߁WzFy[>-n%"p"|^d/Lv%m+\t%Q`YV6.ྻ|Ic ͢` Y|uN'QzL#ɓ.p$FrTOF銮$:ٳgSQQ䐗]J(͟eosH@.*+Ȋk9âcٲe5k:sK/T+)gO@^3wo+YwBF*|ޠj@Á XeBXshkkC"I1G)z K:S@KdxbKJJsiX=YFЅOQAoh`h:*e(KԒBF[v䵷\|~Km]---f}]ֽ6áS."o4nb#m!tml>FU 9”(+B%s| ?ph#ԕEغ{5YX0RPPB~QttD?TO<GKN'oѕAS-4P1)-LӤa;)͟v)U4 ر}Z;))JHnKH6zQEBL8)Ϫhm7(J. Ɏ䑛[@EŶlia4ub:b-tD[ih8@rLs,Ɏ}(Bix pkT.qãK,D"- NGޡOfQbQyhϑ{QA(HĔKcܖv ++b:SƝ[{1*+a1-yoSqǣyQU E)m+u%uv5Iȅ.̴_&0NcJcI)%+@UTPQˠ(*lXa ٯ(G `ZT*1nÅ-c&Te5BЫDyzZμ׋oנ_z.kO(HdtpSϔeTn/̭ҭrc*D`'Z{>?ldm‘O2Q`K Dv(oS<= #cf8`Lq=<M*Zb(6[yrG!#j+tSEAz4d{k7x`k60n]DX;qfM<t G34oF2tI'+QBRg*jl/`J +?=H),O\~wmGk'w\ YdFyøQ8{X〤Z(V:bte@Vs0g6̑1y+Z0rc Pxn $'Ay=8ɭ ބPdM ^d G{NU ͣ2򜏢o)A$Gwzkg>o43lqTAd`1^ʼni nw ¯)Tqŀ{Q Y=NJB!ֹAf}xIENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@??? $??|gNQ@&yI@?M?M?M??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8I>PNG  IHDRc IDATxw|SK^mɶ{`: prGz!G8\;B $$w!BBBb06 w[n$[nZ+iU\ 5ffyf<Ϸ| 0lE0,@𫧾J:()͹sAUTUAA$!mϻfy?F0GqHoIu`Woy_0bD?Ki4T?6qɡ;Pm}%܈,D4-N<CeEE7^(-0t$$!O$a Kyy\qi Tq-tjSwOO]y7xX n6z6Fi錉mkϠ l) oߍ.[e $γo*scsqfsh#_&/9e a`/Ix}ݟe<؏#dP2a#"CL1x;$|c%cy׋FeEVPdڎϰvߑYVt[H;Ey#=6׸qDahpmwO#=q-,44Wi$>UC.UQMYgVl;yYDcIgL<"dH⺥`e ǩGm}%fkэ8/1[hN/ȱxCyw/9@_c0.giwߏ /EM:9w\.tC3#Il:UD;:BP1l*qW_!s͒9醆, AsQBFb!ls胔 }+&pF>x̛ K錴z_m$ vH;!E9ҰP yiabS& EAQnjagfoo%ϼ$IF"}tKκaOi4z46{$٦GF bJ Gm~gqnPJ\vnt#N,A14akX0@axh,L8ҁFN옘8ྞ::­ +cO8^rq#`=5 ç5v|:x`}[.(͍#ᱧdYDHXBZ$)3b 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[,ȊBd MmQ,Ȗ톋M׻`|+щ'Y ݁ǁM,"ӟ-u-9btC;oj90y`6=tdIy>hj%7G1}b+#YĶpH$ڵk1I@ +Ȁ"+x݁~ŽT U|' M@x82u<'(:&F>1Myy9?<> o}D.\r3g ٔtFGuzm-yM?9ӯOؕdfP_w2N{29uvpnj>sʜE?d˛`ök\d ;GAA{jF7t'<mkB0lf3Ӿy3SGU@bȰ7ϚC|SZ>-̆n:Y;g2zt V*#|[z9'">ac&aBZ&{᷿-m̂phY=,^{-jG60p.E0ЌϦDE.ڰǖزMY| '*Gƾ[d 8xgXGX\~784ԕWzx1n 򃇙{D2"D=V[H#?!h_8ahDag~ B/7qxy}džp|ZIdYႥe"??dg2ux>Oõ^ܹ&a5N PVf$vhU2K\Ьc8{>\.k"QaAgH)*T%>)mE/ǖ/_.f͚%y*.q EV֭[=ܓtnVF~v 7u։?ςwt΃wq_o_ąUZ0Z,"J ƈQ7_$Ie$YH*mY ';SȪS>Sܱ''t oF-[/d&HYsH _6ٙx<>v)<v(ȩTx M}J&Izӌ443.fϞKۅba igr#hS?`A,aF> ?Sa9BО gV>0W+[F0GVf<>ݻTcnC  ^s\%Ǭǔ8/cUq$"aU~xfVnF6ǖ(cbٌq?>WBII ~׋(!hll_ϖ]=d;o|Ӯ7caƵcx]t ?2hlhÁ>5l|>~?@R/Č uSA$@Ȇq ˗=ǬZVfM}s5- \s{z&3̱*#f@uU/(=+E>ˊKqS^<5Zpx=Θk93PUۍ\0P(D<'iC,[0mGA4AQ!7Xڇޠ$Ce" +2m>ܳ?Py5uS;KuݞSN"0%⌉r_>|x'0 QihX,F8&{u3XEQ(Eapr)ŭ>rbWa4-ד3`7s^駍]ߛ W!ȉ.[qdr9~ {u> <B!ZZZ؜B;Q$(0PQ啓UJnZ-u󪫊p35u gkt|dIfWL-̔ç;Ԭ| aXOin?B-{r-R1|cgo㫄at]'Dx<\.3ZE"{O.51cy6;ʦpݸ\.\.UUQ]u~+(*.ŅȲj0~hZOV"[k{3Q7,a݇ge`@Uuj)L%w>TnZ 6oLe{(6~oD*aS0NgPvG#Vk.#y4';b+ siZS|R@@[g#.KsqF^viB"Ry2yA{(,.{4֎dY! !8o$)V r*̊  FpvLw.OֽJ?`Z ϘpS? Ǘ0 MV6jGG;8Ұ˜?_Z`Ȫ㣳W6Ҏñy֜FrI@0G,Ad\Uu*A9gKc܈c'h3ya?N<*S,0tK&:l ̡]eر]4tE=./0!Z'Mkd$ޚۏ"3SVr ء9(a/$Sx߽0ˎX8#NXpd~0ojCc̟y5$1wvo1-ahy& Ix]2?@7hつ.A N Ggl_{t hKVg oJ@*D4^O*v{ ?!o_&$$TՍ}]cH")H`731GܬG-qc*6~cHaFݼǮ&.:V$Ia]$#,5-+,Wb6ly\>:íHDNfhHHHh4>oh, :in;j:I% fF(T:xh,D$IKQL\mƉAyd'7E_ ӟC4H])dqD$VJ@vRc)yۈIi ӗO[G#vFYAE##u6QSwА⼑xZ;hn;Ѧlΐ\ȥz r792U? ;I؜`)D8BĸM*.‘v/҂VtQg;w[˗IЅi5ABܴ"_e?句`49elq!}HHx Te?ɴ*#+#*"baӆN#>g"Vi&]s'gY7]ckXvY$-ϐ3bU ӏ-BqdYp P] eqɂM! 4زw5ϿP+B;+I?r+2y{s/1cx#ßq :m6RdEd%gz3Q,"Ȳā, Q[rf0鄵%IbVO]bQSfBmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@???ǿ$??@Jp @;@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9B?PNG  IHDRc IDATxw|3Mْ\$w+`0ŔS)p9rI#_.%@B ̀ rod[Җ))+J{>~w5;gV LYR1b!?IxLt]ťah`z>v B膎͇ J0'iT-qf3(MSy'| :quȲŽ-s85)IR(-+v^;0$ $zHQ ,[ ¥|+}7ɿ\ɾOeo}[e&e O F^0*O #MFI2!adžmoXk ^{gijg\,+ [\ǘıI#Y$`H:fO YQd7.tC9@]fM]}qhL!@!z?ߐ`ɜeY^=%)ӑH6}$VB?Ϛx)$Be$ITMO/N 3[z~+?L~.XN]cE$eDGB" ǁ IB*js|g,YLK&UArwvɽޏI-H B08qL[ܸgiQ$L7D<XOC KD$*jP]WF]cZ+o-5VT>T򂧧 ;cPV16 ɐ$$0UIF]NȪ"P7.m?_Ͼ#Adn:>h۸|ѝ֢r6N2{q U Txܾڲx3}?c.a3j=%Ǘ@\CZr,R2HƥT;(ŗaM$G)O9 l}1 $˸$߾w<ڏ:_$[Q$q0 ة<. 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Ìl 41 Ԥt2rI$֮;(q?fhE8¯K0cEN> Rr|;uvDT@-$Y&l ÇL0|Tukp`-.lsDϊG✱\maWl-E-F.[pӘ8Wo]*8u`gJͶ}k0XNJ.[Ģ*8hI񲅷[{w]ЩTוQY{T-iW5Si7lLsM:$y -hA |{u|/oW9lDKLe۾5?iB3xM?twc̰0PBQyp<ﱦX5$oi)$ɚ’Fr~8NƖbkghXaiumn3u'/pJESo%GGAb/i64-uKA3$x>jQyڔDaz]z7_;c':q&Z)D\e}ni_ ش_lΏBX_j!p%ǽ ?pt r;zZ@7'se#p^rB&e'1v ςY.Cr͊bGwiߜ\IENDB`move=1000;blend=1000;3Q7HB1]VVQ  j/j/ZZ_j/ T?kTUKj/__Z֯ZZ_!Z֫ UZ__֨P_]_WZҭEBWj i?֢ZZR֢֢jWj֢j/Zj/j/֯jT_EE֯ZZ_j/Z*EAZ"QQ뭭_WZ__EEEUK_WZ__T5Zjj/__jZ֢IC""URj/֢֢WEE֯WCZCZj/j/___jQ֡P֓_j/ZZ֪WEE֯Wj i?Z֢֢jZ֢խWC֓QQQ֢֢jWZ֫ ##2223###2FFdddfFFFdddf@ 223###2 ̌̀##2223###2223 ̌̀##2223 ̌223###2 ̀?B,%pf BB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUDI*"!B"I!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUQ$""H %UQI""$DEUUUQ$I*""$II$*"IUU$DBD UU$IUUUUTDDI$UUUDDI$DDI$DI$%UUDB!! $UUUUTDDI""I$UUH$$UUUUUUUUTDI*"!BDB"I$DUUUUU$H"$I%UUDDD""I""I$UUUUUUEUUJ"$BA!J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUDD""A!J$I*I$I$UUH$$UUUUUUUUTDI*""!$UU$"*I$DUUUUI$""I$$J%UUDDB""UQI""$DEUUUQ$I*""$II$*UUQ$DBDDD!EUUI$UUUUDDI$IUUUTDI$J$DDDDI*"$UTDI"$H$$UUUUTDDI""I$UUH$$UUUUUUUUTDI*""I"$J$DEUUUUQI$"I$UUTDDI""$"$IUUUUUUTUUTD""HB!EUTDH""I$UUUTDI$J$DDDDI*"$UTDI/vbinding site for residue peg a 196ac11~binding site for residue peg a 198ac3 1ubinding site for residue ca a 199ac4IL1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 1TYFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESII1met->mse selenomethionine MOD_RESqq1vbinding site for residue peg b 196ac5>X1vbinding site for residue peg b 197ac61vbinding site for residue peg b 198ac71ubinding site for residue ca b 199ac8PS1ubinding site for residue ca b 200ac9F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg c 196bc11binding site for residue peg c 198bc3@B^`vx*1ubinding site for residue ca c 199bc4NQ1ubinding site for residue ca c 200bc5D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg d 196bc6<X1ubinding site for residue ca d 197bc7PS1ubinding site for residue ca d 198bc8F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1ubinding site for residue ca e 197cc1JM1ubinding site for residue ca e 198cc21ubinding site for residue ca e 199cc3@w1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESrr1vbinding site for residue peg f 196cc41ubinding site for residue ca f 197cc5HK1ubinding site for residue ca f 198cc6>u1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESpp1~binding site for residue peg g 197cc8"$DE 1ubinding site for residue ca g 198cc9PS1ubinding site for residue ca g 199dc1F}1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES''1met->mse selenomethionine MOD_RES//1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RESPP1met->mse selenomethionine MOD_RESxx1vbinding site for residue peg h 196dc2:<1vbinding site for residue peg h 197dc31ubinding site for residue ca h 200dc6NQ1ubinding site for residue ca h 201dc7D{1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES%%1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESNN1met->mse selenomethionine MOD_RESvv1vbinding site for residue peg i 198ec11vbinding site for residue peg i 199ec21ubinding site for residue ca i 200ec3LO1ubinding site for residue ca i 201ec4By1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES++1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESLL1met->mse selenomethionine MOD_REStt1vbinding site for residue peg j 197ec61 ubinding site for residue ca j 199ec8GJ1 ubinding site for residue ca j 200ec9=t1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RESAA1 met->mse selenomethionine MOD_RESGG1 met->mse selenomethionine MOD_RESoo1 vbinding site for residue peg k 197fc21 ubinding site for residue ca k 198fc3LO1 ubinding site for residue ca k 199fc4By1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES##1 met->mse selenomethionine MOD_RES++1 met->mse selenomethionine MOD_RESFF1 met->mse selenomethionine MOD_RESLL1 met->mse selenomethionine MOD_REStt1 vbinding site for residue peg l 196fc5881 vbinding site for residue peg l 197fc61 ubinding site for residue ca l 198fc7OR1 ubinding site for residue ca l 199fc8E|1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg m 196fc91 vbinding site for residue peg m 197gc1771 ubinding site for residue ca m 198gc2OR1 ubinding site for residue ca m 199gc3E{1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES&&1 met->mse selenomethionine MOD_RES..1 met->mse selenomethionine MOD_RESII1 met->mse selenomethionine MOD_RESOO1 met->mse selenomethionine MOD_RESww1 vbinding site for residue peg n 196gc41 ubinding site for residue ca n 198gc6PS1 ubinding site for residue ca n 199gc7F}1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES''1 met->mse selenomethionine MOD_RES//1 met->mse selenomethionine MOD_RESJJ1 met->mse selenomethionine MOD_RESPP1 met->mse selenomethionine MOD_RESxx1 ?333333?333333?333333???????@??? $??@5|OF+7@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10Z:PNG  IHDRc IDATxwUsm+ 0H+"1`Fc\M1ucv71}cfk,5X(JH`^o;{ιwv΀f>.3s)s||dC'݀!bmf΁MhG(+$|1R*FR\RB]]jPSSC]]=m8cs% < sKߛKQN&ͯuxc\v#H)1@Ai:L8K0!k<݌/i< =]vYF۞ ȓN⦛n;D.[ ;!9P/7aCcti qlD$I+6y44Dnb5n駳M\-2k,nf`ԇ\o`Ƒ#جٺh:R: 6xknhʒ6:1̛7[o}m&Nhӕ+W83g΄K&8isX0B ql%p*DZ%lMhzuc}:`TdF}?.T eY*z *<4MH)lL`qVӊcZ :b-&(h=@,fړT{09%!W^ 5DZټs9GJ˖Ota럶|/ܿ΂ x'ɍ)‘j1$IJvp(C"vX+11@⌯I Ft,럶?ǿ⋙7o^ikk#Ŷ-w>lH0v4 =@UA#yzVւ9yyڀw<*+;8s5\âǶmFJZJxNd#'\Mgn Ѓt`Qg`r)4؎m$8weB`X}!=矟'x"8A HL3BB=8ƝLIi#I4ކa4X )%'!XNj;H Q1#lshPK/=Nnׇ\oinns;]38#Yb7 /RD8&6刓;{1%#!m$`R4VK[Gd3;]Q-q.D2b2P'}}.=ࡇ-[s޼Cz'|G444PZZ 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