3.6-1h/data/swissprot/ 3PEI.pdbdupa 1GYT.pdb*[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Cytosol Aminopeptidase From Francisella Tularensis[/h3] [p]N.Maltseva, Y.Kim, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3PEI" target="blank"]3PEI[/a] [small](deposited on 26-OCT-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1GYT.pdb3PEI a_3PEIB1  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I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃3PEIN"Nz ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI 8 ? m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm  tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???yq$??O@35-*@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residues2PNG  IHDRc IDATxwxU?ɔ$:" ,ʊ{uuE]]{[tײU׶ H( T&0a$P&a>y2s9}o=WtX z/~q_mO9Ojcl GN2f7r@ cmq1ϢʄXr@ktcmqGHnu8?<%% IquM9p;OiC46nd_Gؚs\vm۞'k`Μa IWII0WC8]o.**j"O/0x]#FpHtFrsǒO;zK 7JL<]df^Ae GJ߿T̚@̛H̟7s8 P$]+2dH6hQX5܀#Nqq=$ @؍,R1`]t\v>$$<.D232xXҍWwҽ ..׻&з~BFKa{QLHի/RjtôwmCjE$'en?7'-\T2D@I0a+Bfժ\8(=DžL~ YnDju6'z8t&II3Q([[@޽Q:-R`Mc4;w>աP\5G{*bjN% a4.23gsX,sD-QRo1S#RRЩL|i1cH17];AyR*L ى)MVDAקOǣ78uw )DџxP9dݼb^_GzږR9`𓈴$&ś{&;ذᛃMJ̐!R"U*AeE8/=yXUuA{3zkK( (*}7$&q8i[<'c4:U G 7A~YLpKJeaE$&$IltJ3 ]AC lgѧwHVE@/s}y+in^IEEtp8ǧc2ePƦM!AW8_.Y.3dѴRQq!L(:ֶ{^o#r€,in@CChuz[X>} :+i5Vk27>ڡ- n8d{:zUPWK--:t3ӧصwdy:rr0f_P(tQVj=s#Vkn9w?%{2zU \JHKK~$RQFc/'!aUU2pe(p]PĶmPZ{A*YB(J`Ϟ'D<*ƌ d.?+ژ^^<(xp:#hAYa̜yZOE.1UE設] 3IkvY֑`hZ|~ [ nw['['fd¥8(q8P_%KЧ(vijUWe嗟s!X,Cٳ獰^ZG `tBkAAJOK~~~^\oGEZTE|-G0jkNZZZT&ZZg x#995\JtjtZgݽ>pF\np{ByvyDmFzm^$4`a~~XD,1tiͤ_EAYgӅ{4^K՟!IJNK0 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I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃3PEIN" UUUTEUUUUUUUUUUUUU_Nz ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI 8    $0i2R¡ `""ˇA 4qgީjMQM5벒8Qs&ʨ ( &X@Ic8PeO*\ 4DTBtZʏUTED\@,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???%%$=? ߏ)@@36`P@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfacegPNG  IHDRc IDATxyeU|/W-RIdKm fnvx0C1a ! ؒeK-k=߽qS1=TiȨxY{7=7oOF%?w/Eʚ,Q=tڮרLd$ )!}q0M0__&LMMENkz? )xR) Ȣz$La7Qn7 1ڢǘyaHdxJP cBQk=GJT >˿~7qnHGoR44Q0ce7mӷ,>>׺] " In؞G& N࣏Ǻ [?";(͒VrFE8LJQXvG$19:J\& 2K% ~#яu]5."c4 C.nosZɥ-,#m 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I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃3PEIb0N"L$* I$I$$I$I$I$I$I$I$IUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPNz <"-    eeel> `..6`# 5NղF4kT{~Un3{G&t֮b~W/7xq3M* wn|=!{[WVaAaP h!K$WfwV/TJԖh3JH "0'iIf H>`NK'8@R ȄXltV: ww zzhtKAA0NKgK#2JRFT"#u~X(-f cRKma:uAAA?N~T/i1\CĢB> ax%0k]h\f,kWzgb՘*y~$,+תD*EHGǤb^bI48PZ2a|dɣ ެٛu<0gu2gM1/@̹dVggaĔkwrUjf''rTf(!TX$@w=%v9:4'^4 ~gZStkZ~Т<qm& '>bJ ,fQQ%-h(v9,nFKҞKv â(fe .d Jx2ᩱ22q֥A<sc iƢSz'mC5*zU`I]ēz;y7;B,(z,@X:7:VZ+7MBb8[ڭi_i`UNr yU4 ږ7aH:vBx|~>r#bPH@ PPMK Q ajeðj U$AJ&$B 5&h,fufveWJUFM^# _uF'JSGP O",6 -Zџw/a  fwMw`~muEVmlYVC#ȑf""Xη )6*<nyurbS,EWM; Uw"sfWUA6w_/ͻaj8h6\1=)Rmi٦yF/LIUmҺq Do,һjM49S&w5HJvqKSSS[ޚl;yaTI;7(_:wyxUbZF-؅2 +"NZZHA1D-0I7'i,xBٟ/Tk]t+^\> BIL/iLOAHT$H%J`fjC42' D`RTabT[*fC,k-$3 M)F ]F dD a(eF%EfE$"IIVz`XⳣT M![m^ܖ7W&syKy{7688[wmMD56Ie`' Vr HקHplLtI8$]J4%g$¦ 9 y7ɗC4UB;AERTH fu֧?B}kmJZI1 t:<)$qwwwwwwqqpR]0 {6$D Bx^~=&H* B,PW1%y+uPFnI"XXA ފE X,P t^,+NFuՋ[g&$b++k_rg~ֺ/|=척FŚnΛȨQpܪ FQ,]j+J~>,PzB+Îq9zT! \t^3$r4BZHQ21ڹSK45MlPQs GI =+G!t`Rǻi-PZF`^q \n_0U^`wnۍ'bF5ŌbAtdI<Үz{_5"攠\6jb`zbAV əxVfxXV(wNJ81@f6+Ml9DD&*TZ͕aWON5ctU#) 7ϱ0BYE@sE`C&a*Dj" CX0Z"[yQEjPpHqf܃w8tXrXRX1" C=t=r'B{ 'dg;T#8 rkHcn̔^4,8x;$7 G4~ޠ@rʶ^T6vݚ5^5xCPnǙlyF+%^UŭeI,dfgN>,oZn8(+); `Me\&]#w@)Pj찵%@::$J%0C kۼ݅MNZ4N%ךWӌhk#5[+K ;"Tꏉ#ԉ'TJ4'G($ʍ/I5f3;lVQjJf-hn#EXyU"֤ȫ4XsM՚+/N[mc3ٝ\Iߙ aTMEEkQPmWFr(jJmǵbjG-Ϋ* VpZ!qr0H!:=wwwwwfcµ8KlTU^!$B U),H{jvgo=/7%3FČ 1qŤAp6*ɝlLUWxf H"!Q%İ~@ L32Ht. C2,L2e&X@&X2ʼn&Xbe&X&Xbe&Xbd,Xbe&XbevbŁ8    $0i2R¡ `""ˇA 4qgީjMQM5벒8Qs&ʨ ( &X@Ic8PeO*\ 4DTBtZʏUTED\@,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???""$=?lq? 4@j5P@?*?*?*??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition,PNG  IHDRc IDATxyյ=300"*lĘhyi_Z\6.(***DTAQqAADEaeA5 >,y[ݷ{|nuԽ:PPv S@Pξ ~.]+=ڧA)=Mu{[=M~mteQfM>wV ɢLs}c !rNuw,Ā[n` CY+cF#܆0<V "dTp&WmuȊx$N@, D0!+Ȋx:珣 uk'$Ep58¥M_⥕KkRz@!ˀC^1AN"ot(" dl|" ckBW=3DD-*ї}1ӯ~GukC}ד$@/?^ej?OͯT; \Vٗ}|s՗jɛX]-b0E@T7uQś4J)yO[QvK*+oGn.f,|y2CM<`S~v)2k ՛$_Brr,jg CЭG]m= 4@&|\Ikۂ C] | (45.[{78}nM@1IPסvhuyO*YT9&#pځNS~8x®m71St H;j^^)1Ԇh77h>6_;П(Ps'|);mZYAx\FWJFS?C yi7£uVzoλ$#m{"^Kioey0%(/OoȐz[Fm}x\s|F_/.P|Q4(!N\s><}~"8}| 2i{t@8ri3W?<1]y:r ÿ4v1p/m,2={ݴ}=W敧S_̱7z¤Afۤ kjP<CsS8@GGB \_Q4Mke!LIS ¿ͪ:-;Zu?LY.Z9 L++t6>+^+C;4˫`*MEп5 xMۜPE{oBPLpcftS6;"A4[}N$ɬK0?ᾐإd=*nIkn+֜u\1hOC999[G >Nƽ'I?`` ƀ@>@[M0Ww?RܬM6lJ[QƇM?hZKGR@r ֜Hrܲ D轑v&w:ezsX~:GFlӖdݟc{ݻ2C=PA3ΆEEخƥ:lEju@]l2\z,gۂl7vLF rsmĐQyjxtTL#[E]WtcՄ57CCvlԪkt p0L̰joNZV 8i/fo+՗t8$8; پLg DŠ?} 'i~- 8ײAJ>Xc󐣫Q-_^gژhVRS-$oʌ w夺Uk$tO@K_&Y.D",8Q[xqx؞n0h+NTf_}9JiR | łkPC0vV̭P$A|}/CU<)ƛűjoҴKQ;Wr,i [G:>YЭAs;;Wݤ|ݰ iSY4i? d> 2  0M-@ =3Z D $ f&%㽪`06ȣ{ $]U-7$nT*;^Fvn4Bϣ֌w1š9^JW]HH ~;wW#3@|6 ؐ:RE_%)-GD7 {C-K@ )~,o߄;N=M>]%`'PFW6oƯU;(_!#T8S @U~8*kۍc]OLcHߙEP<>e0vߠ V\Bx4[ykgKe/.QI-0yfa aAF.c4JWOkD#± J*h 8x$}C?0GzZ%fPqk("{ɞ7? `Y!xU57= ?W1E3F֗MƢLcP;7l` is²e˸Q#Lhj[B!!/A]ɞ0 !py5wBy[~o@ ԖBE'W?*AL5*kl Mb(qvq1]-j_N[̋(S'U_ ͗作TПlyòx6mݏN7t]|<' NC<QwҶ !mMWWйbP#.Pϖ,oЀys"<;KؿE JT׹75 xpY$v9I~ Uw (,J"@ԃ%NN[P?=qd,Ib_HD֡_?^? a <[z%O*u1Gu>K7nq4*ingÓ5O T q gtū|j1ȒHDf8%Ѩ\L2=_2 Dۖ-#uK5K+ӱ'؟2FGP-<ehX .{!ؗAJ P_3?G$5j31yϣKڕj;G`A @v*+Q$rǡ'ڣɣJKi!B)*RaCGE.܁.A1BuOsLPӒ?qy0S4u#{CmB. C8M=9Fbd+$RԸ奮F=8ϴmӦq'Gl(m1K?Dd=.kW0_Z6|piݾK'X:IYZ04,H^LS~_7S]CO2] Bid^^^zB= 5,(+O43ףxͤ~=28 7'|ΙFBDC*d#/8/u)\Z -:A8__#QRGx-+xf&oC-AW=kK7VUJUXCF)EYYr{P%$Ս1x]xK%7sqra Ũ^UH͑}a:ʧ_.V7h@ݻyڤ8T,9g:wQPeEqup`ͦ%o9V,s樉Q(dlg?Zϸ<6Yu'm[PDs$wK&͕lҞ!F:^z`7h`}1xe50}MOԑ$NfNT.֩.NR떥)uT_PnuU"z'?l=pErio#qoY8Y$"-x6!I`o$:-SSkJy?V)Q4KsO=S PѐG|י]+ӛdH8Nяz_j&y'^d:ܽϩě]g{1--ũ6=nSF S3*wUT~KQ{W)*:_y26oJ#)ICPAz"?gҿDVANF*I[hP/hZa*_D@Pt҈X|cSϣx4jq; TTpoj8*4[eF@F9+P| ^~;AC8[vt>܍'b414X@;UsFzp g8I=ǘQ^͟>5[Ha ↂɒSV#T5.dxY0P#HqéhxRh{T{WϒrUiӽ_pm0 B}i]eS\-NC~*gb&{/Dt1QLW 8EUCW[a aIDAT"D\R*%ӅhL#x}ZKA"+ $4Å 8g&k06ѳ06 D&x}UC&WHdԄp8\ Аp*=fA#\VB7՝,PuFʺ+QWIڥrQ7zs}uDWQ5Bv35/;xyU |p  .!0]?A]!WHC" !w)N*dJ4*Nw!Q',Xy^k ghR^zL%[ |(}*KbЀ]0QU!UgdfO0y|xuw?u+gO@g棻Ϡ:@DWBq50јRp"[}!4LiU)5O ';Vhh)h<`@-~GE@T"섭PCL/ VTbԗ=fz?oDw[8w{E(DMK2F^M@]̢~&8!&htUj *GCB;#*_*##NB݋ J12@>vZih(Tx͙0"A} Wcxm/<$)>A-%A[j{ާU(Sɳc:H5s\pAjĞx0 08VفM= ju O;=:3cD .f_xjb, qLxm8^&ב>اX6,[2;b/0ux^ -/ IV цp}ɡc\bqѕړ?%gʽ)!cp_E&m`HP6_Ho8kdq9muz ]һʸ`E=jK T:.w8q7kfUz%y ެt4 39h"]vAmO`. =7U VpvU.Bd!h?ǹyTpaҤ.AFxf:4S@r5Ӛ%Ez[c@Q]0 81q ʙJ2BZY٤ '"~NBC ;۵<KCp5/- !H6C!p>{+@"n/16 xNys@7 W/ɕi9$Я_1]|i'?XQ /Qmo{99"v1Z pVn]Y=x.&{z8 !b(Hugz2/dQ1Bģ+zm8QU ` kJ 8s'ۋpci&$|8la/3 j7'aCZmySg)p*O<٥qBt)*9CH=TO!0q%|+lUjr0ԂKpk'HWvvlۆ㦽qt&1|.4tqnp78qU v[C5C37"ֈ2ڠ'E;0 8;CiLqX aFveV@fo9R t!>{8 Cve#ӝR{w:H08cuPKK%n>Rˬ2X{DJB4z©q 6Zp!,AKQFl,؊ttov <.la_Ǝ;z]xפo=TRX:4I:ɎbogճsY`v会&4 y4*Ϣ&%gq m{x{OѮ/qtGa;-(~r=<8d [G6byy2qC8î,.^!fKEW'Zvv$BOp[誆?m;pERu"l4WS_= Tr#@!291h%?U5>j[}^BǂA^^YyOL]~2BCFmfv/Uc*7|uD/“$66˴-:0 c|A`^]b#%h&L#T1M3yH=T5t1 pOMq䋐]LAQu+dёBoFn;RU h80hOPU 5B<mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYT%= H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEI+N"Nz <"-    eeel> `..6`# 5NղF4kT{~Un3{G&t֮b~W/7xq3M* wn|=!{[WVaAaP h!K$WfwV/TJԖh3JH "0'iIf H>`NK'8@R ȄXltV: ww zzhtKAA0NKgK#2JRFT"#u~X(-f cRKma:uAAA?N~T/i1\CĢB> ax%0k]h\f,kWzgb՘*y~$,+תD*EHGǤb^bI48PZ2a|dɣ ެٛu<0gu2gM1/@̹dVggaĔkwrUjf''rTf(!TX$@w=%v9:4'^4 ~gZStkZ~Т<qm& '>bJ ,fQQ%-h(v9,nFKҞKv â(fe .d Jx2ᩱ22q֥A<sc iƢSz'mC5*zU`I]ēz;y7;B,(z,@X:7:VZ+7MBb8[ڭi_i`UNr yU4 ږ7aH:vBx|~>r#bPH@ PPMK Q ajeðj U$AJ&$B 5&h,fufveWJUFM^# _uF'JSGP O",6 -Zџw/a  fwMw`~muEVmlYVC#ȑf""Xη )6*<nyurbS,EWM; Uw"sfWUA6w_/ͻaj8h6\1=)Rmi٦yF/LIUmҺq Do,һjM49S&w5HJvqKSSS[ޚl;yaTI;7(_:wyxUbZF-؅2 +"NZZHA1D-0I7'i,xBٟ/Tk]t+^\> BIL/iLOAHT$H%J`fjC42' D`RTabT[*fC,k-$3 M)F ]F dD a(eF%EfE$"IIVz`XⳣT M![m^ܖ7W&syKy{7688[wmMD56Ie`' Vr HקHplLtI8$]J4%g$¦ 9 y7ɗC4UB;AERTH fu֧?B}kmJZI1 t:<)$qwwwwwwqqpR]0 {6$D Bx^~=&H* B,PW1%y+uPFnI"XXA ފE X,P t^,+NFuՋ[g&$b++k_rg~ֺ/|=척FŚnΛȨQpܪ FQ,]j+J~>,PzB+Îq9zT! \t^3$r4BZHQ21ڹSK45MlPQs GI =+G!t`Rǻi-PZF`^q \n_0U^`wnۍ'bF5ŌbAtdI<Үz{_5"攠\6jb`zbAV əxVfxXV(wNJ81@f6+Ml9DD&*TZ͕aWON5ctU#) 7ϱ0BYE@sE`C&a*Dj" CX0Z"[yQEjPpHqf܃w8tXrXRX1" C=t=r'B{ 'dg;T#8 rkHcn̔^4,8x;$7 G4~ޠ@rʶ^T6vݚ5^5xCPnǙlyF+%^UŭeI,dfgN>,oZn8(+); `Me\&]#w@)Pj찵%@::$J%0C kۼ݅MNZ4N%ךWӌhk#5[+K ;"Tꏉ#ԉ'TJ4'G($ʍ/I5f3;lVQjJf-hn#EXyU"֤ȫ4XsM՚+/N[mc3ٝ\Iߙ aTMEEkQPmWFr(jJmǵbjG-Ϋ* VpZ!qr0H!:=wwwwwfcµ8KlTU^!$B U),H{jvgo=/7%3FČ 1qŤAp6*ɝlLUWxf H"!Q%İ~@ L32Ht. C2,L2e&X@&X2ʼn&Xbe&X&Xbe&Xbd,Xbe&XbevbŁ8 44 tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+1GYTAfffL?p}4+3PEIAfff333?p}(? w $??KWJ@@?@V?@V?@V??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10,PNG  IHDRc IDATxy?oU1 s0 ȡ  x#Qk$Ƹ&c]cL4n&D$QD!r_1L_Uxggzfzgtw~}WB RضqޣB-mmsl_@`I DJ)%ա u5x ~M3FC"Ul&6` _yX 7 ="_sM4xӊ!&44V@ ]8s_ )mӌ=y~WK$PǾ-LxmR>%Dc!n (#$vg@t$+E>YjN3l8RJ4!Ei]uZظƖMn߻Bj|}w1+\cK;%h/FrV+X̑p2ɝ.O !B-tFIt-D=Ԅ*c 0t# .cqIB"&B>.vD3|FZcۺ?6}م|O#--t\>. 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I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUꪪUW"N?TUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@z ee AkP_MjCT?CT?I֪jWiu&_*T* _֗jU_HZ֠B?ZP_P_֪ZP_/ABW*U֠j ֨PP֫Z?ZO[WRj ֩?u+_!*U?RZkTH"DH @@D"D$"D"D"D$@8 WWfW#O* tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??*M@`% @:@?0?0?0??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2)PNG  IHDRc IDATxy\U?ozߗtYaKȂȚ("888 ddQGaT0,3FY[HH Z]޻?^UuwzNQ]}֫;s9WR,ie ()[_sv[6: @"+ʫDUUTUEQTUE4xk@6#~^@T =0B e,.o+ @U-Yحv\Tݶ-@r8r]EȲBIa%g-w>`:OYtdYAU$IF!~A.¼rsJ.BUdI'A(ul ʓ1uS z@8OOM||Qՙ[i唢QzÖwQYRj亊> (2I > I̪^pwcfb:=d*&/k/WdI'#D94?BN _C %wzl["$I" yB(WV,%,T8z"0"sͬ:"^XC# a(*Ue?)bzi̩;O7o}nl\8k {vvkԖ<9مoΤ>C? @sA*Jf I"# aޗ]SUYKGwm]@ji$7¼2+acI* ]! Ǖp4C]lNVXxJWVFrbCT s(*(QZXEKdW,&I9ּXT@7-mv7XJ`؇挓G CȒlhˬLMSs^'.G<8#K=Цv!aLd z?X>f,DQdEINg.eᷰ6TOOii?ïPWΞfC}٬\:۷oǏÀ Ô8Fo ՆEt*Ĵ $q]CI䱪E1uސ &RRX4-y]|;72,ngO[ؽw'’%X"M;wEhj:s9kĴ(`7G,3Ѯ/XMe4\0Emi8΀26)IYdz[V#m10Pьiہu7+=Hvz HEhnyd ZfR炕BU,^"0h4Ѝ^/42()@BBC7b\H>ornWI4Za/`7v[ figgNtֹ>ݚE 䥭8͝h8DE,TxkKwO m:N乊Zli 8R/Łi1v2/)y~I!@d4GÍF#7y^cJB8)q0mAGpɹnuBn8p:3h1v%1=0*:Ry3$O4ٔ2Mɲ8&MDbx?,w i_iMӅfc{/Ц_3i(grWIh$,pUUȎe9"(qqr0QduƼ `Gq~ C7bV5p!xZ?60j#ty[*DX4gêk&:HH &c:9>ޡcQ8٨il™k潧ץ՝7s]N4-ur~ҝ0A/0 =w<4cW0 I;a ]/̭]' x'y}tڐ$ .@S1-?؍?! nDbA~P\&̙"m53/y[10u?/;‘m-]eICiku|蚤mۊ$ v3 PK8}5HRZ%PcLZpu]f<-ɔ+"8x|ݾ!/klJz 7tll{`ߑ7?}L}q`x-G:v}7c-_umڜs\73ݙ}4u' w}#0'~ <ㅶi>ܳTw㤠m]G \xL\ĭgNK{œn\tB>l޼`jW6dCYQɲed:kIX4\5b.ظqܲZVՉ,Hfx 2H_ũjڰ`f,%]nhJX/-JI)ydtʕ444㏧t7 xIvk&ӣtlV;skW0wJM_ K֭Ջ.f{cجL~!6OJ8c <|HD<~Uo@ݗ +gaQ,Nr\d98m9e|5n_w++5ŎQ W]›I;X6# (p{cE/ʋf|)EYyᇸ@O(ᱛWX0矁 FNel;Bܮ",R5߁Ö9bafqP`Nߦ8c&j摟SF$]H3;IINzȲ,(<O^xnI]z_S-΋Ed66[rD!^|wզS[J O~Kg#h #)ф}И<Hu\fʹW>9iɣ*^'7r-']$sn]mBr]KDC Biq =NyP^4_hI4 =3YFtzK.Ce <{x Ϥ#OH;ؒ~i.“گi)*/o \)qxҪ`H22RAbzi>:ed9l{GgfQ?f*VT՚4d%Ĺ!hM`޼y<'_;6ERYP\r حN|nJJ%Rl]ݾV՝DZtAQ-Ȓ,,y%ul؁!t:<,MF֤ E(*fP_"`}/W_}$f>MfU/@ϹŎ?Ӑ T |.rL}¢!PGw$0۳[}E)'E%Ci w/b{SO.&z)tV{EƋj좭iF_ 3U3ifBno `؋! dYYg3o*[=C^<+Z# 7nog,ʒđ$NOӐɳNJ0'  uKyeGj0jEyUp#WV'huȡjq`Q,'& ' OνBC[(ίלg5J 0I. lg.N =0㿞 8q](Rg>>9VHhqpsƝ;=M?愴UW94fYRG<0̨Z'˞b3T3rjr$D)]/fӦM\iи$p4/=nEa3QahS?C(2,,l6b;u`[6lf4M8˗/zHx_m墏/6j0$;FJLK.IS+/l: [9k1髒K/Mfd5HTJ=u(ɲl@̮9Ĉ$t4.33yh ·.|wsM7\p8z(555CҥKmfqpI;~}E_ģ^_x}C^$IBLUw-L ʞKaeYI()E#'я)=w]1]ڧ7ʎ}ϟ|ɓS68󺺺4j =Çw-G?Q 3gNr~h4J`xeXoVXvϨÖі=|!$']$Ba_,fQZ0 !]G}p9-%6uI0%5 ӄ Rr n'2Q.sIJe!ݾ֓d-/N[23c1?<[ր<\.ͱe& `7p-D|Xkhr<6aOp]'? oz|soCZ:#P[[Ν;y%h~逹ufܽNs+L`Zv <{cή$ C8+7g'w&i曩/5^r%{ 9x|GRx[R(.}ڻilވu̬\gNMM(_]j|= Zk%Ibw8x|g&p /Eqg|hϦN%ހ,+t{&^4r2㯦'hL< 3b>ʋfP]:9at]#w;iqm_ko}g<&#f, LI~MIdCa=v?d65eN |S~kWk+| >T5r 3b ;;ӗ͢8jP(Ċ+E^kd" H4D(KƋW$z}഻PV E3шoxrp98O1Nw2v{}r#}c}/}Kǐe/;8azc|8e/b:.g }=EQQsbEVQdyI&! 4 >^}LJJ\G׵QzQu{#I٦&wu}0#CxSJi$F,#Ѡ9sfT)鯯imGQQdKՔեs?$ɽ:[UUxO-hzM!ק[rUW~TFJ~3y.9KH" Fs` n" 6!Mm"Ff9܀$'OIC= =ï)iэlW:Ͻߏ"!M:D I;! tL(#z=IC֘PqX#G]d6̾9F<"@O13Ho$ԈN 3S+4̙S׿^]O[,\'S?TG=z,_ 72!0P4S[o[;SPcf:I' <' g}6/M>|X`xH}zjXG6jKMB]O}1jT!]Ư0\ ȳn::;;q\nPH$?ٶm[/YN Jmm5=|˽YTx IB8p`l]t[lK/3=}R \yhzX,BT 1t]:V^_l=yZU{+_:IX㛲\Qhu^C+o~30 ᰢi:k=/2O<63 c_93YxO_MLZ<IbO!1z2LW7ߌG`pLGs9G\wu>_zڕ>۲Dnvu_NM|1|V@V,] bbbb EVG]y//Kf׺\!݃dْFѦ"1$|s#Aw! tCS)Kt}==l&^=_H$D?V1=ڴ̾.m/s䊣,+&q.|ha=7|©Cs3 J03E1w3=#M!"r,u(jΠɛ;i s~z8 .]OSOq el3}j33"ӣwN2]Hz;QsI E1k+r-x))oGD.b Njm۶g/"~)5*[ەKq_ޡ d6 >*g,[@YRȼyIG~O9)ICݤDeLl:~AHc#9}tdư4HK J[[۶mt[:w}U\Pd;h+D,pC*>y7xo1t5;h̰dee$t8$ 9וhz C7}̹.OjcyW?fVѴ໘72OoOu&?O s3*QQmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UWUUUUU_*N z ee AkP_HT*UC*RjT!RjJUZ_]IWO!ZUS֩PZ֨POj j C֯P_j Z֠/A ֪P_'֠Ui[OA'UAkZ~B?ZCZ֩"D"@$"D$H"D$D"D$H$8 W!WpWWf#qNUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???*"$?? 1JyGg6@?Wθ?Wθ?Wθ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3PNG  IHDRcIDATxyt׽?mI b 69x3vNs; 8=x3q<8vdy& a VwWW՝?Z{QoSHuﯻ @R PE(H@4mҰ(6H/;EB6%i)/,* )P*KS ! w4x(`pE=EV P;EIE(NcYay(9)E못x j]SXe;wbxm:qx EϓwbsT٢)z5&Mg{((bVyK)E7/œ?ܭ( (B)Hœn{eet} |'YyG]æ#Vxs7RSSäI<#Y+'A @D s.k6eQ/g}o|߳f͢ӧHWW?2V@0iR2|OWٌِ+FxV\ڵkyL`LԩSꢺG}4^N [Fik=t;*3z亙M7Dyy9ַfŊ[nXlذ 6d6\tݰzu(Н-BW͘1fx^<@؏6mso*)! rtRO<̜9 Þ={O~@>ihnnŋyi;gsߡC8q"_ؽS?rT< ړ={dkkkJ[oUN2%|ΔS(&ƺYhz3RJo&\s Ǫ`ڴivm<3Ij/C=nuL #ZR"F{%;@ i۷;w}-N89Ɲ9.*Il2JJ7ό N0w[-K3{V_~^,{jػ7c1јXY`0k&^mkO;ހ+M} ZUUQUβerX>˖:sE ӳ'BGG7bc*&)Lz%=B K|[6 mj|'S?v*͎xzh1F)c HK0څA=?voWS8!/^<\rKS} Ȇxx*Q_Lg6C`֯&Kc] )%Ǐ_+G9ďD8?~~c+F<\Q' x#.g^~]|pJv=x|;1C9gΝhi͚>;6(aS;+_Gu|͌=im*~XmTykժU򩧞 ,\tۓΜ9'6MU^Veu`li={Lxy/2y !RUKD%)I5+_JǾ/… *<|ry[Z{.)g ȺRɧ 3|IwH&|6v}{{SWA %pç?r^[(H)n_Է֘8oq~o飐(lܸqT[ajϺEs h]^y~o-l4S8}_~ Q\tţziYh---9/Q6G=/"}fV׼ ţz8r2w+>i2e6md7P0hzK.s!-G)/uMlڕe }D"A8%LT[&Mx`sg% )%>__7r=B`<Ϛ5kX3"H]׈evARv!R0'mgBz2; `ijj~@D 54t=J, fڵر#*OX E#h0eXcR70X"ϩhH ?܆3gP]]r i0'K$B"hee9/cgWR+.ω3# SVZ-lڰ~zirsHͨ2rP: +Jbdmщhotxt]#  z3{ٷ" #IXA74ш^9^A-'0Lݝ"nE咵k2"r3Sc`iA4=n MLZwLj}Crŋ3c yq锫0LCEÖh(v%9E\UqAhPYwAuƍK~GF.:aRD=.BZHOV.a꘦&ϼ>K)@O+ $%5t=S[R(:e C0"Ye6) P4ÉMZ=)E&qd6CX<[4I%HB(|>x#"Ms|uGs`ε1 4{ryb‰ /9cO)\@]+) ;}H@HAXO=4}:b`Kȉx0t'„q viB8b$J[NgiHr%Fdh|q3-f_^Շ! ۓXi&[M|q/vեє&m*m`HTW8~o \j{oP[=~hSMpn&qxL>9*cLnk¸O+/'!nęNo3 ݶH=0SץmW*Vij$?)(7ډHn,}4ظ3@BXgVYJU]d)֙U:U?عޔC1 < ~f4[-r>Mu-HiGHa{_ױc& ?j hb%Z{J~=ʁSD͓zLiM4͔ƋB/~s9 n}?`\Ҳ0eb.cahTͦ}F)M.jmW"rQ璦U摓[#5ZĆsI׻ ոqx%cL χQS!X,ǣrռAbb]qm+k0XVkac[Z44LHU|%hة&a-higS7 0iLCŜ<L8TIԈ8sVBfo1.N1D#o5&@}gar g׬iY|άzUWUQVR R Ű2KDpW[b/Yӻ4 4OjJK>ԟ[}üszx<^TՋϓSqrɹS|>qmW?= >oF=F<'I8$ ̷YQ#.tQU5FxC0I8MD ^|5* C><CUG;-:OO֍(\;|5:O8$^m- (;Wz_IENDB`move=1000;blend=1000;3PEIB1^^ ~ ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI PO  m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm $RI"I$! ` 0@$$RB!mmI %$mmI$IHJI$mmmIm6II-M`@$JHDR$I""""mmII$ DRIJmm! DJIm$I%6`m) !B%$6mI$I%mmDJI$I$!l`!D""$JAB-mi $mmI$I III$mmmI6mi"I%ilR$IIDI$DDDSmmi"I$DJI"IAmm!HII6m$`6l %$!BDmI$$Mm0II$$-l0`""HDDDIH!Bmm$$B"mmI$I$ "I)$mmmI&mm$I$`m6mDI)!HI$mmm$I$HII$I( @#mm)I)&m$lm$!BH@Tmi$$`""ImI)$$m  @DRIHI)!BmmHD@Mmi$I$$I%$mmmI$mm$l mb QHI%$")I$Mmm$IB"I)$%mm"I%$m$mm6DB!RIH mm$$lDRI6m``"I%$$B `I"II% !BmmRI mm$I$$$Mmmi$mm$mm D )I$E"I$""")mm$I"DI%$$mBI$mDSmmHB! I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUUU_UUUU*NUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUz ee AkP_MjCT?CT?I֪jWiu&_֤?P_Z_U!j [Z iAAZj AP_֠Z/ZBCZj ֤j?oRTkU PJTZO]i j UOiR"D"DID$H"D$HD$HI8 W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$?? QGp}% 0@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4!PNG  IHDRc IDATxyչu,00þ . (D@ o@I51\5Qr ޸D1&D  " "(ʰ300twUSU= 3ݳ0Z9= E~T*iRR|ifB% Yv.R@@c/xGtM5} bZ!T|z )7]p pHDi"/TVlR[\Vᐅ$$9]35EQQEQ!s#8Rt#GQU])I!d e>R|/:Z@PYUߑKBF~-@j|yma6QXeZX躎iLMEUTTEs>屠@Oy,?HG6V$0߼[iZeaDa(Φ*ξRUSAlٹZqgeu)'e A‡-lKiYX!^HQ|*JM'R\r \SN54GTG:*sgpQBla3eeYfY6cFXj8Z|F!((UQ_%ijöm#<:ā$ycFO^e{7C۶<躁l>?6(?uڣ(YM$Qܾ+Z gh+D\D6z:ĩ.Cf&mKa[qH Fn U5#G?#\}9j]$GA*# '5>MI$PE\(PVQS|((r.Gg$OУ@²FQNM\%Rk/V0qu4Iĉy8$pw%<88ݕtWP:$O b.' @U$Oy*D:'$|I p@BICq%$X]h'ā$y}x*4LJT3²#,We$}mA/ُldWϱ" LiJ W}]9E#7$F^N/S|WB<3r]='jJ+ qdPXvqnEi5)qBn$ u![wEt'(K$O 3-GS&li>y\C` xA]Tkjw߹&&KmhNR);54U:PŊ^irY.v>"ѡ0IE2l}՘6nnsƁ^RS2BŲ-L+ȁ턭=(+\N}ı/}*6͘7EkItxRT:C"Mә11)31w' slh>8ermmZzcY&b[~֠-x@zp{J2.j1U@,.(*^3d؋Y88z}w+>p8BؘV7ލMr5g y=*;Dl%k~[}Hb]їӲx(+bRU͊7=Z,ĴBXv!Qd5u/,߼U]j)k7<}_^(XC]GsPŋq7GfqqnLP(@($₁WH١zc&]:jwl1S,\q#VUc(#ϿFۅ il!D"زA0w~g  V%l ǔCy[e6'+K+!mN}.!#-lӲ5<ߚM&!aN<1ar̛w-yuXV`~:AK.Q_"p-V%OA^ ͏ߗFZJ&id搞(NlAHBy0A\NR1eʅuzfjë Է/{^2XH"%Yju-NUSN a !3@zj3OL<'sstO^8,ExfᬣIqaזhT#3q끏0hU!`[JN;ŷ#|8s̉]ӝŨ(r ~=>5* :WN~s6]c=a{w3 MRg͔ĿBNc{O: y}yh$Ozj69]0n8ϭڬxuV^:-]on:3UVV0t~Rӯ0'y XD.vmիY}e]a*zϟs۶q{{!334B26TxБ.撩E=o sQ O4.z ]^y%|Bo4u@>`֬/ZP[ӝ;w/ϯs~Æ QDž,Ymn YbA&ҁ !FN]ױm-+u>v"_;];Ç4@ì]M6{>pBfϞV6 ǨTpS5eTVRYu"r T`%JpXrBp"(O\L4 !+v>I$ϔ)SHMMիWR8sHMMe(aΜ9lٲޒ.&,~ܮSFg ~@ xU[<\p-c&'VY<|̚5|(&>ެz]L4'OqFG^x@W([̘149pm3h -Z#<¨Q2dCeРAR͝;l<ǂNrd":ECvV6,o6q~,3sLN… ۷/cƌiz|ck7PXXHaa!Q:n5۷og.ĉ3QF1c z!&OLNN#F\Eg?XƂ"r;xߣh*Nӝ%=.b]cz(|=k.? G>} [X'X03=\$TwA**KD  ּk֬a͚5,[~ M$ 48P/^ǵ=rF ?_p?0~!G\}ձ!();BP婓1aq$1n-beŨ']bE\Ϛ5K92Θ{뭷G^ztYŋ[9ul=E^vOѿkb`dgUeVsD$,-A>}(//oRxs7z_^ =&0Ky'׻Z'sTNS=B\5f1a,qbؠZm6l{,fΜӵzk|W1Ϟ+v(;Rm@'y `B*J|ךx ?YymرcLrq\yٳ~o6*+OC^g卖P$hPAEB> tnpnHV?8>h;v,9999r˲0M˲,9SeYvD6ݡsV5ٹOvq7z_ݎ!ر?W}ҥ\wum݌&_&99{*!l/;]wuZ$dgv%&dP}c3pNuN9Β%KXbE[7%&VPA3(6lQxmwEQPgyVZs=Gڷ&J+RU]A p@?HDYEQP[# =aʕe˘:uj[7'&Vr x%A{[,OA~pH˖-cΝ,^^#6J+qrjBf ~=_jm(39j+vVW_|8) uO:S5TVR_*~#] Y+x}|^| 8qCz I[l|EQxں)gkj8r$O;DZ%g޶HE@utUA2]>*D5 ޝۛ8tM 90ׅIGlذ7{lH%-$ϙV4#8RtyhB:\i:E`ID@ %̲P$ǔ+X:#'ơ(G BPRIql>:_n]V$OcP Mu+ [~J"6H;<0M4'ذI+Fvvnt͇hju`vD*96%l.=O7j&GS54E"el<MLz_HJ+GLб tuT/eT~a;²Ml´BXV7y$0ׅQ߿>zcOJdvTwe&2@< 5nuM.cSc bZ!f`:I8fQ@Ut6o_Wύ"i V%w-4&:]=_},L j֬IDATHTjMGxxa$y:R(N7 O$@ҜyUI$+t вIu4@<97ZƤ (7-q%Q 1:wjA+^<MQ hapR (|(?UUEi+IC[#A=It0Dq)̹ +t0(L T?\ y^IENDB`move=1000;blend=1000;3PEIB1^^ ~ ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI PO  m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm $RI"I$! ` 0@$$RB!mmI %$mmI$IHJI$mmmIm6II-M`@$JHDR$I""""mmII$ DRIJmm! DJIm$I%6`m) !B%$6mI$I%mmDJI$I$!l`!D""$JAB-mi $mmI$I III$mmmI6mi"I%ilR$IIDI$DDDSmmi"I$DJI"IAmm!HII6m$`6l %$!BDmI$$Mm0II$$-l0`""HDDDIH!Bmm$$B"mmI$I$ "I)$mmmI&mm$I$`m6mDI)!HI$mmm$I$HII$I( @#mm)I)&m$lm$!BH@Tmi$$`""ImI)$$m  @DRIHI)!BmmHD@Mmi$I$$I%$mmmI$mm$l mb QHI%$")I$Mmm$IB"I)$%mm"I%$m$mm6DB!RIH mm$$lDRI6m``"I%$$B `I"II% !BmmRI mm$I$$$Mmmi$mm$mm D )I$E"I$""")mm$I"DI%$$mBI$mDSmmHB! I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEI N" UUU_U_ꪪ*N:*z ee AkP_MjCT?CT?I֪jWiu&_֤?P_Z_U!j [Z iAAZj AP_֠ PWP_B?_I/ZjjP_I?uPAZ֟P֡P֪ ZZ!RJ"D"DID$H"D$HD$HI8 WWfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??hmP՘C`#@?)?)?)??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 52PNG  IHDRc IDATxwՙ9Uչ{rR(g!DD0{\gwm}? 6k, x1`aL!y&ts8U3=3=3WOk:Ts[y{ I,wHzY6\ʣu$ݴu H[w>#gBX ! d$Ry.Hli#m)muN_EwsǗU e hN$=a/~>Ab5U7 M[ibuNO?iy< $!\wj{ߑ)휯|y%CBp*˿*)1*Bw"Crw [GP2D]厮2\-%nDJOE"4 q$T]JLJf X>%KۑfOc~ ˾" #]a>zZ͆Z33WR]1 'O;OM)™$HG࿞u Ui KIRĈH]U,~V6liK$66;`; ]i?e8ա~#ȑK_1!V-B/D$TN$\A8}_cshhx_=O,s6RJL+.dMO 4!# ^|9Sҕm6,W @Zt'u:n/Y_ņ34)@:'  WP&PD~NtB:p%?͗r״Jr:@i!BЄz2݋)Iɢ}fԡX )@6+4 C Qb @_=򭢍/Z(AIme#bBDÕ}fڹ ?`"DÕIyX;?9gΜ 6Y{u8"C"E 6'u1 D.ZN`J,[DڄAYiV6 }$,֢>|$#Ә+2Z5ۙݸQ}t` ضM&2VO"ݿPW5ڊ锗ա=}etMG =E齃}Fo;H;G[QN^B]lj'04m|e9#mZ`KVmضNvd='H. 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I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEI N" U*NUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@z ee AkP_MjCT?CT?I֪jWiu&_֤?P_Z_U!j [Z iAAZj AP_֠Z/T!RJHT!T?RZ?ZO[WRj ֩?u+_!*U?HD$D$I$H"@$H"$I$H"@ $8 W\WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???SK$??VFA=@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6#PNG  IHDRc IDATxy|Tg%;d VED"Pj[[?-j{^]Z[XoR\UZ uCvHYg3LpΜyf|7 ';?WնFVLDCTCidD$.jG!Iib ci8g$ɢif^<} aj~_I0LШkrӇ dH0 LӠG:ss,aDP2i44D!ROr Pd4ЌMխʥӇ` 40L{9?a9^=҃4zibJCJ? g"V[Nm@Z)46#23EVIi`i4yi4 rÑe!LL@5tC)TsA} ٙ%?񽝪kP@DSfā4y,2 *>*vuFZӴc!8H#3jYeÈ`&Շb 垛aϟ S4 BI&OGf0YVYRe$2M! wh2ݗaanH]YV䀄;|Ib!akt4 !L!ȶd$YCdI b&4a\4y$4yқitiiɓF&OF{ٱk+݇& Ϻ2I=MGQ@лBt&hD&dINr~iwM9O2gMTŇ,X aPu9nYx !\SU9g psVBϧɓ @3" L,+.xޗд0iLw^@E"5~}&OuGh! 9ƝRפlBX^@QdÌ~&4bQ3[]K' D]c,=u)]ibe ocąz 옃}e;4yumz:|9ك,k]CE x[Pe(TML/iW[č7H]]zkdCYKjI+s>z4"zؕEEQ|d']ZtVb<=ήo1 gO|Nש㯯zi6Œ$?}9i%%%TUU}Ecs-5W@hzVnT}qU*HB`X3N5=l%ϢEزeK`nT zF$q/:U)L;d{*,eӾԁ4yg=ѴFenK>!&,)($vtSO'l{}tkD Se;6vzNJ%L{a~s-uh~b*5ce,&R jP%w,KpE7l4~A?ڄ-Q4j6@U+>Snf0@.z_gdۘ|qŒ[bɭ/t?UQmΑB!rw'Z"?\uU=Y༑(JD SPii׼bZ"0-nh+u$CX.LapǏС>M?ߞ/n(IJ CV/%(s; l~驮ŀTŇ"z?`-Rl~a;uͧA!P-uMH1}M' q~ݡ>}i*P\\_~`p KMlYYuыgew] 4pk[cGNRVVǙ5kKxXl˖-E3(D 05udϸ:$Z:"k;|˿mEL98())!77zݲoRqq^yĬ30hpRPVזݯt!⹫ݏ>2׮; F];)MHJ yfظqchЗ9YnWih J?RCU}ױhI5So4lnjbi&o… پ}{hjr Pe55t4#BCc 544dOi%1lXKm`{ʒ́uK[bHY4IeJJo_իWiӦBCC;!$y?"46TC}c N# [$ddr~vgo!z_H5l=eTVVp54uM46u8}VE].; &ogBAA~f(ڰur8\Õ9Rޭk"K8NRQ- 8$YJw$xk9:$pr72(J?8R+mm 46U, Zo2Wc<8NCM!b3ռ ؑӻI]F!)nIZ zI=(G*đ,UK&g 3w|eRhswٶ6tGIЉ%CvY&ClDAg,W?AjK=-݂8h^L-aΔeIGd?!k:\ɯ%6lo-MC,Yøej-?YVD˧ѧ3 ] i@8r=^~́XQT.2FEyy9[n Y O XA}@"B?O=憳x|{1͘BNN ,]H$Ν;_4 *KܷCA-o0-#gz|3{|[jٳ dff2vX&O#Gow)GUTdYEULpU"?w"iJzs;qʗϧ ~3KU%%%§D),كE~p1$ 1lX1H(T CCy{S" |zOw3W=C|n,]{@=)~+1f2i$t$!`ué@<,9 tCF5e ge#<ׯ1q d!K=~ GS $t;WhC/ B<.Î*Zp ǭh銊,I.i| _&@,Lȟ ,ImNdl$E:#GG7t"Zp}|!M+.XGf0YR8T n=~LTOПߗAF0@6, Z6æ?ޡ3a\gE2 9|!Mi+;US][޲>N1@E`6A dgg=36µ+@KXw0 BSk.:{ CEU|;q/|e>֭K dg$Ҍ0cGLsECFc'x8S=A(nD(cw\_q (XNy3.kuwmK:j6aǞKvfu_^-ҩv-oxف!#RʓgތK7r:9Y9Vu?/w.'x$9ɲ5~4R~ 3w~úۦ}7|mGƿ,f\ +,m?v[k:h4qg)䌁;n IQdk'yE<͛?8AO#!#rM4qwoFnE+xbqGp%m+n{)?l~pC#`yo?t%!z{s;BiH>a*>tCaKyI_Xﱳ[G쩗Un%~4y,EEUmo㙯Mq69$D$k5w7B U3.5t)4yLYEVb&%Q P-PZQ&7wG>M+~Gs~ϲi˽zS'u)Zr59̌l0v|r.]K/eۡC0'?gɸqQiB}A]`V^1#P(с͊38DBgj:I)Yy5|,[~ǚ5kb-^ Fȑ#),,d,_~5$Iih"9aQl8']y;+~6/ΝG)M+/w9O~*++']t,K/gEђ5p:-$I3&\CSysL+ZY*:%Oq̜8Yo` 2۷e67v]$>jg[!#ISKYS)?p(GgUSk2Uǖhz}:΋-jnIֿ}|z-EE&-t|`.>6!XxGf>Y)te"ޤ~_sNDu cկ~ 6PTTs}n Κ|իWẃ&Gh uk{ _Yߒgɒ%̛7M(**bĉ 4kng֤Z[?/ L)Nj馽$&z}K} џoذ/3Z_bM&QJĦvF齁 Oaa CCggQ[/8ν~]&F$O~~>O>dMfD0LE1x`a'XKXj˞ ۉ~&r˖-έpތ˘1¸OGuV.7[?oJ4=bƱb8yΌ@6CH9cxP4B@1Dr-:;?^UH=ȲFEAUT@⧏~=a&,$@((Y bpQ^rT'%2z=!HYƔwi#Qdp'%EرӃo$ٱj0gwÍ(U ` 6%EFA8H];)X4g5-f|z8|i-Ow8&=Xq$OG4Ѷ|FՎ?K3JΡl;u wx \Z8q)KQK,8 BF7柮PU U= @U"z**s+<*$vz$/blsc;]#<͡EWhkcgA(O6a3bBn6v4/,ߒv?@0p=SdO[N%P#?g}5J=ev28$oPqKOTNqS4:_U$Imt)K;hϓer #VKVeSǯQ`N0)xk鎼 3']D-=G\){#m0MP-{M5̚K8[-ևE&!o>&-;YVoOM~I}e;bK[GuY9ϡcQ6)k˻n$OKW.qJJlŬ341i\{7Z~խmrڻ z'SeYzGg@O\HП+=4F#4EkL5bؠ1=\rEEc{E9<`(/k0BL]JrsAjjNVSSSMcS !qH(DDkf L=MSP3/?c/IҺ>yoAlmj %˲d竉*=-YdGQT r Yy~V.ooR<uM՘O^B:B^Xi4[cJ@lG#K2sKl}*>_wO(iE0}8(LĘn¡)215ȳlMmgSNhZm^#V=pTN.,J#IFL]iIDATNuOEA88S Ok̉G{8C,8K]mG^gҘ1L5_4aKx$C;0qu" BFT{8qWV%-Tu`P8t}MM] %~뫹;%\P$?f"M#BpnlI` XqkŲQ_x F[aSF8x\qU^{.Sv>GVv&D#T|>P(LѨY-$Gts-%nKsS/'8R/&f!($)S3o%9@В>[W7إ<*xOK^XR74`C)'y<{tSp+?BmI<@К}|*sPSW顎%=,*tmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUUUUUUUUUUUQUUUUUUUUUUUUUNUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUz ee AkP_MjCT?CT?I֪jWiu&_֤?P_Z_U!j [Z iAAZj AP_֠Z/ZBCZj ֤j?o_I/¥RBI UHTO]i j UOiR"D"DID$H"D$HD$HI8 Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???`X$??L@$ I>@?K?K?K??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7 &PNG  IHDRc IDATxy|3s! KEEEp ֥j*GZKZG+H- "(!77w1sɽǛ9ss. (6$ ي?={DjV6X-6(98QLfz6%{aߡ mcWaZ!t@F Y躎]Ӛ,$$)AK@%|~h !QQy3섶1}Vs*xɲ,cر(VŊ"[$Akfٺ%i)Y!JZ]mdj!A º1#a#HKn6D$!/NP PYWԺ4]5X&xwz_Vp$YFz3@Tl;FD56Dd!-% Ex(yRtP}J1uÊBGׅI2RJ## HE?zy/FoaDj5ݜ Su6e; |FMR!$Bz2S>|X$K]Y "csOu !olt$Y!CItˑy'Wi1&1IF#$$YFB >(q=uW"jhȓTXu Վ#ՙI+>CBIqfD2:cY荄Ȓ, . hHBKXQȓ$y ~̥ gBP A՗:>7.s$CH)l$2u! ʫuiyގn,B~u&XGӅNcDd]V֔t;G!=OBn7o׀7Ј߈[v4cVj݇/`}-c(  8{UOAAd4MSKcoS=^_{~ѫmk5$@ cX7D݋jf5njznbBzI"OwpJ4_YNO5wo% >yyTW&R+tR-!ās.3u)C{8TU¶oZߠ y@+T>|톾nRaTD*s\ά u OakQЄ53CfVk;dcXlȲ?o>j`n[n%==={ 7=I-ά ]DzJ6Ryˮr I~诘1TÌUA#oy*jF |M׿&-9ZBNSYWFm#ot x_ba<*ٹ#SK;}[eee1:22,ք$ώa#pȲ"[P+ŊEi_x^ldC-$jY@Ȓ,+Xu˯OqYYجV8p|Z7e ͆?2b| _੧W_}k' _e@}].Bص+ZI $Ɉf꺚ȒcDzl2=qEt]_}uֱw@:>?038\ GeLwu?p=Â'O0h6>ż?Z /}/& . "q˹w.t0L}5ٳ.юO,:gGa⸣W<eeޅ߹#@`G~0x3:ܜVlk[Pn rF9zgnf̀8ȓ'^lVGD3[ o0:;v,ugߖ5Wu4 =:U^"PQTdI1Ro<K5YB(ƍ#''5k4'55=sm_fY"1'\F+ Evs剰 Hԭ5#Κ5j*[s_kon'mFo-z8.ߛ@4-ė&yg/^Z(vs9U;_|kZEiN+iT˂.uz˙"+mau[;v #5ͅfuPYI.t}QV~cٌ~5\D:39mE|v(dŊl?n$ -;e˖O$Ѕ@UC9 8$Ή'/8܅Ѕi:38:D, Ը[f\~sUV95`ȇ?ػv\s F͞=0~G0V}K}Cno5no! d*]_nyR|nn[;ɓ'{0 fi/͛7石`-Z 7W\ƍټ,ك.t4:B4:*) lxy̙$;\[ +} F+V{V>˗/g|=*]Ĕ1s"!S4k*YiYPLUM9oKKbuK?Hy fuD5xbmO'L)Do$X8˘1o-79b1#2_x|݈O|~0Z "kgѢE7x bv;,SQIE'^iuk0˗B7u= BA#Wx嗱Z$Rtiap؝ج%AU]s^EN:ձ#+ݶ~525A} U c)p"ƀ~0@7li]j$ӡ=Lmvπ"Ϛ5kζc O7tở 8'`>2JwDɅ}h*4SP۸{<̙CHF]]679gÇ-FU]F5G'cK!O ynyERNo{ ۞IwP^^5%KpgpAV^ @^Z|2|!?F$ ~v+1:mEP6HͫWAشi+Vӣo bo㦲2jv$,lxkߧGZJ66X=3OYR۳,=36Q!B1cưtR8 xQ`:(ژh؈wGq^ӣj֜0ĉ9ףv'vWVoū9Puh,mB|u]`YcW\q%%%]iӦz ]#O]I{N?sO9O?=u`ߡ2Is nu;xߘAo+13PRCiiir۷oo)Wfngaʘ9)8^zZbIOj6ι~'D3-`K yBnN=UZ5[`JF6kR>-Ixg.ubQ^xIu+2N=i0c 8|vxa\l޾S+T9ZcΜ9̘1UuYs9P__vxzhƺux&/K.缫@{~bfu +n<#=׀&e]FIII8o~O.gVo]îbl޼3gFׯ_]G?C$+,oJ(Vdق"pnF~Tط罾X,>uYfe.0}.?>9#3-ڎx1ctdFM FN 7s|QU-ͅE2jsB2FP}r 8ڴ~z6oL(bʕX,,K4 P["]weOvq|R0-Ja𝄧GHLx3|A~3Vlv G\{m2.F;wdʕy~ĉ͉r뭑?^B g긹l/N9v)yMsG#K2;~_ ;L2_ޞ]qSXlڴ{.$yoaYZF`ᴎ1JKK5wnFCK(yiqNSC @}CUs2F `ǞE|+w~] mܹz @inQgyèo"jrgi.a22ڕ8almpPԩǤ gà"?̍7 Ƙq&* ;*j2TygB8XUVHF=L,ݣy>cnv?|{0Qܞtehy&vك<6Fq 4Rіlf9 Y_03ro2^,Xwy%??^ˑe[t2/%$U R}x?vwY*;H9l˘/*agMطo_ׄ%;71fQr{?kJw"9EIoS,ӏq{+=@0wfb<6c(‰Z:w^8`H<\,uEWHnIDAT1Vg{,; _`ЇԍbE 3W<$9bR!,VQgϻ:G D!kcRSY7Yzt<7+W3r'BA˙jld_' e$ $㴧"H ݩժD\o9Xz=zgKgOݜi nu" aL8gͽ2:6k@kdd\ti:M5039aO!##>6qa71`- &t +>we9)ȒIL*GR\ejUK%5 a4IfF >Yx1`]ig^$ 0ij @0~nd;^@+IVDXQiv^^mˀ'd]W$ .6%Ӟj.%HxJhi*34cv{c1ɘ1ޤ=ǀMWA\Es#͕MT Id)!L]7>%Ϝig#AIG(:B1.8=Š Of$u D$LB7f(ݑ6uԳXuل!:w^lM<]PU~D 3HHY yJFIŎ:!]х`g/$ aБ'bMko#Q6FFbJW-yZ7Wd,kZ(J3V 4Ê3/^Vocɒc:u"Wx'߲ȒE1|X1 P/h*2> !5ȌI!/63Z4D1{v!*ʆ ROԭ8Jq#g5t]EUc_ FU RjMW9a`]I4 ֶl)׶'854 M}tI"]\/_$yo"O쥤"hS0(" L_$a"O2.a9@5c,mTtǛ,!-;bf[ɀؘ.+r#uafL7}]O8TCU i{cH<8Xe$͜|:{jmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUU_UUUUUUUUUUUUUUUUUWN??UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPz ee AkP_REJ֪?JZRTUQR"HUZ_]IW//U?Zjj [ZGOj j G_֠Aj P_/Z(jZj ֤j?o_I/Z֟꺨 O֨?ZjZBBBBBBBBBBB@$$H8 WWfWpW#0$_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???%4,%$??uN+G-).@?A?A?A??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8EPNG  IHDRc IDATxw`g?3MZ.Y͖{qܒ8Jh!\.$. !‘F8{d[O{L]i%7k;3ϾyIgDUT~ѱ떿*Jwڰ HX+j=r^$$$J;OeQ IV%_=1x 7X[o\)0s) /Pg~.~S&wxu¾ܺ9ab AmLi_J;0ܽP먮d eE̝Y%'y~jo,vF:N5T4Xb _4R>lsVgxo}, r^t i0f똂'_~(/fOYɲ9"I2$q^qƼKinKUTJZsJ6U1OEg8 sVpW%xod8H4Iř.&{Pho-e+D[w3Dx`cT/@7T Cw_;kuhzpa_Gan900 BSg< pH(/'7`!=6je:tc:D4M]l$IBd}1h7O쥲d2-(i@`ռѡ(#->z̝=6.{15L8!pdO~\Y! 2sbv4J}4IH$H,{8Ҳ`eOmURFYa->_B~VV RVTGyQ3䗛≈1_甒S 8#imxd 7טi @£xzvͽo?iV2ev|}7q:3gJz|| VF:I[]DajPs_uF{BsJX"j8*gsQd YA w|qn/HAn)%S*?|fc?p闐AžDï}j*f"K2 -FB2ko(ߙtYHQtC0 :6A$ FcFv{mwe֔edggKnn.99:~7cں>AB"9|,~6[X+A=,_Y2Mw5f㎧G@P{gBbr2 /zmWα0`shlz//q{LMv[ۏrDcX0,o}f\_bc X"x/f_f@jPQRo{ؾUZy<^kvu^tx,{) OENV%]|m?ѿ}x"v1͗?CP(b\TȒY$bdI&7XDYa-y9%Yk.7f1fs]Hm+wrtV.%q4]s{pJ'OZ(/c͢k= @71jtuwE {n`fx%5 GJj(g V$u<B4Ћ>\w#L=L}B Fa YYHHzBmDکiVe0EyHj&ΰ{70ikؾEu4uP[9ð a YBk?pM%"6dv|%l1e4pER MoۑGeIby}YUTds #0LmP!H+c8tl;i01ͤs>=Wyaۄ0퀩3b\%ys(dIAQ<>8&ϱO c Xƶm_eCHeS_ŞGݞtuzx/*/ox\}N{6'_ou%W/]s977ܼ\Y2{ MOF1>jq![D(҉"C0,.Rg|(h<6.':#5}^/=Y;套۷>xi+V]uǎ<˲}6[4x1 SUXB$Cm,d`9uM:{3l*,s1ozv9-9Y !9C_)yD&͚_H9ypq^};sXGtrM+ز}G޲W#HBp:(˲DNnSw[ib 4enhi|,5O@ve{P]b8@ h:nnT` P+ gtW^ُorp;[>:fw?e5w az+ɤ1.=M&tRWN}܁Kxgؙ}q9Q_AcP^\ߛE:^qβ1zB.y7T6ʒ)TSB$~{1g;q"47ΞK۰Cv""$9C ,L0aNd8kvv΍;X 5JCqhMPU:lin݃O34 k1 S#DT;BXma9"U4='2$:`(-F=(ı!FDx{J￟步c46s֒\M|z z#V4`n0 f,bjB-`Z&'$Z[ -NB[K|{J;8)ίBE~|F`K+IɉDP= I.G7^q=}/iGW}<YROR{Az0m9->=='p*e%-④l:ʦ1f149 Qǣ:/l<Åc@g/yě{Wo =6 rKGU| 7x"BkgVXF%$p`"%5;;cah8(-C쓙ӕ4(A$c1f%'8~D-O^0!0Ϋ;usdgP=݇8]sDwm"7UK Ǻ Eť؝mʤUuwe}歀X_pٝ<ĝv]ΧaǼϓ#ƈD9tl}4|˹q]@$d±~I2Jĺi>s mMPVX{zPG)Yݶwf^h+,mrDS]_wszttu/mC@G1wr qJ(/#ʼn{Ihqxڻm׌`Xif=~x?lJUi=_ SGT1(KH7p7.O쥽(9~ h>1%SCiWcHΞcf2wLE׺NӞD?T&ō!;"{e)."'B|>1 b=6'=@W Ó>0k8Ҁf􌐰9GeIm|QA$cwl<`W[{2o2pPf Ml 9O:١$[|asBW]#7U ӑ 7'|h=q-tfm`͢_i*q5c/h;zL4*K0MG)^74fN>EV\Z[(R|_?ӫwv }QW>nZX"<&G去0 LD<kZd$l,[d1YI#?ǃGfQWNQ^٨ژQD8CϦVlڴzKF}ݏ? uC'"$8 -af9N$ӰdLJVx<%˒E,+=nDdكG} -FOz>ZIIhq^؇yk>5_>{L\[[ĵ.zQx OD%B$(qW `答S 4-xھ&,#xd<5:ȧn;dɝ;}\=ѴxȍVkuꍨʋ/eds⋹Z8<`rx6MEwz ̨_Em_MW-h,cʩĚX $SGǗW3D=Da'3<}YpVW9>O^ .󔗗ӟn2/ i4 cbgZn'hں8cn?m~pw݃A=Ȋ2q'nB.Y}OAm M& ΫΧ>)z8pÀtݴSδ&0;oi?Hi:`~D"x06_Bx DUr ܧvF7ACHrxÊp2[;lD4Ű{ʒ)(Y˘7u H^\`n6fE+o!F-bm;}2b$dq'DAtH"󡛬 AlŘoou7oUON#uWαܮnjaWPpuc5 -NBOڹ 5QsT`} 歄$9Zʣx[o}v~t߲t6VQ?GB$~o6}NM6.=LjzUV,{NiьZ$ڃQrպO>Cje9Uб.}}+V,g[tyFoa[iaKH֠^4#NBu x>1li`FRŖij_iDQes.B{R8뷝 h~'?r:;li'khiiix^>w *~fI~8t[^HP@>N6E3m}C+q4 }a:[Ca3a%k^7ylL'(}ݬ[38c}*0Tq_;||ǰڹW$ϡgbi ,e4_^[9:GsVZLEMO*X7H'Xe5i4Gd9aFM%p`3v H!!_ly30`uJ89?@:1~%xd/|A<5쿾eyΊyYQ$ܒFBY@9fzJX1lqu8CVa^ň~Ecy-O=/￟~^ŭ>l[oXH(Vf( _?Ǐx=ditLӪnEHQؐ+¾(ajv:BafSVc #2!(-Ξc9>շdHĦx>_ك>NynEq~,j%!U ?qΫ6LGr.9]NU$%.l΋/;v5kZ:/ν7Ueƪ6i awY$Ʃ/̈́q2/ʫs#ΞIed"- PE~ǜU+ڢ&4Q(~*{WVT+Vgq+ T`K\gˮDeK)½u ~9HMwEqѠ(2Ez0(xcāQ!;R^T˕>bg#x>V.OB'_"[i')eItaYV$ۻ))vK LWߒIW_圳ϵ8#CIF4 wQ_4ÁpN6Fl<ͭ{. yp$@xP칊l[5떢$rRHRcD`e8vvVohzEG $$S0Dʿ8W=RqYsia5m͓N2FzܺJFCb6(G؊VdYYY$-Yg \cͰ\ Q& !`nv wh> @r>?M0jҖ/:;(ZقUv2 !^>xg ;ڞ{3Ir&?z4@}"9w$N` f΅P0'; kPZ8vղ2FQj +K z7z}躎W\Yg 7 IDAT4 $޿5Bݻ@ źa0H ϶w73IH1&InMj}ZPχ6>6\geH)mK.2 $IqS& R2}.OLӭ %  !ew$)4"}C\,Z '󪀧?7L{޼f=78^[Qfew~+J&O dv`y_S$iv(^{ާǣ#Izt+R1P@$ᡇ?)Dn /g?i^%@ǀsK}lXrsv6g)jfe8rsP(|H6ڥ9".dRT=yh5`3y~o{Gi;S:-آ ≨]LGR_5boư o8Ȗ-[9x`K~Hzq%IbJ} ػw/,AWA}#&@ >J[WE69 &]V4dGiofeeVVBtCUi,0L/k0 ~\H¼aaV9r/~2/] 6ҥ曬XbmJߗ-?%#]tNqGNz2˦QQ\Oia 8Q~ +k)_U }Wy ȦpyɰBSn_37t&>xbֈ L!ߴe`ŤȽ1r޻.y>||x~#>.;G?̴敓HD ۏ36rNO죭O^{; aR$tt ̢tKA܈+xE^wgҤ  0bZG't4i4w555̙3_|> g~;_3/#<2u*BiX'mtuc僲h#2__UGHHsܱd ƙ:XJ Sͭ^E"a9{:),($>qVӗbɜn,5~ 7@(ş_PV ?Z!?H0+_tDFsNvHHOxX>L2y/RojjjXj;7uH! xz?=2n9%hZ_>f>-y8˞p&p6l S,~ΰpk#o&WM# DrK{;&a:eŵI(={m^z[ɲ iz:H8唴ͻ)LM]=R2\k#)^b>ߛEBQyZ:-W~ӾLVgv#3?qʍ^j -{Z78fbXq~BtQ ݡ6w%iw)>gFS ϼUQS>긴lETO0֎Cl_inn^(ӦM% 0 x;C7f/g s?G!2O?ƒz z[h>#>BpvyT6 CQ<EO?4Fx5^y * X3㮻o'X^ ݳx؊cy< nU57;~$3떲u)!3pN4˲9ګ6kٟ);QX4\dI!@:eXml,}!嘆[3]ȗiK_{ 688ҲV) ,Z MOXʣ8yCis';?\~M+֖[ONUYWX\D?ÁR㩭DO=(Sr zp#,xeիYg?  VJ))8`0Hvv6pp$DC輰1=vUor4`s>GԶ5Eds0 `B*f(r8x2Y慣{LS?퍯[|@ZI;Th|Y#I` $ &@_IIu>INIIg+CUc( { ZSV*53٣wW :7n˖S%YW9ۥZRk8kфi'ϗRUJFnM㓟 \yDczz {1 CansθήV~ nڑ̲]_Cv8S+6UM`1M Ky0t-4 pc\W[iMTTLSi}7HV:p͈HڊYVDAmTzZt|}FХzKK/ӧ8q) +YޑIeӒK>QI*~[lSK Z;ٞTÇ2Ʉm8vSXy N HQ{lG`tŃ`H<C(|'L7 ,)Ü>a.(Ȣ-[N^`k3U,7G{(ҰCe[k CKW ؞y4\xճvօcV0>y E"+%Hc/k]M8Yyti5O;F(Ӹ >U,F`՛Z`|ҖԲ$?ޙPx\-Dz9Y);N&[;RRPM\rĆaw~Z 5k>)0 Q6ˣx)VCD!j#-hjd7x]^+?6O'4>w<?uSC7T4C$ڻvsSW/g PdZ2ܿ^79[9q =:>oVqx)SkOD~ k=',\V|5ſy~d]U}, *xW7˧n5bQ(6^ j"0{ʙRY2`1?gST'Ps/K$__vrtr~tQ21oZ@`: Ki^NpH%u=9幁Wa½鑠u/Qu4-~.k WNdb7 Ս9>do!|svK 5`'m3\̟[9dMYfsy{"֤j=I)3e2i Ӱ48,H _qΞx/^`Vf뾗ܿ(Jtۧ P%nVmh%i̛t:khV75@3>`g8H>>}>mULzqe0I^B&`drIs@B</݇GI {M솕v$YJ}VEG[D[kdE! jgeƧ 0JyYeek[o׸&GbVi8ND!ں{ҁs k{{!K)e2@NAZ rnP:r|' +'uB\f$)+ʊ GOs F3T4=ABj1^;:ش$9Ypc0D("+ A?}Zόex<>,l~G3 DB#j?K^^>e唖Q^>z۞@54=fj(^w?+pjPF:R&ѢjܕQ]3JȲǵa xh7'/$C$>X4N4EWu ol|&v"7XD\b*\\CBQ9K;?m82L?^O^؍ VMݛE u)ί<U(uJ"$  HآJ tzV^N1 sxԚE}8%%TS^Tǁ[)-Chz9Iajt m,mx=>ΜbIʋ 1{ʙi2DsaOc#.M=m H̪EW9P$?XBnʒɜ=Z<m?VΞۜaU FT-ߗMvV>k5:7)mI<~9x=^tCG>p Ӻ/<>>w:oI$Z:aʧUL&$ Mh=3&}IDATxrvނ2IAM-T֐rxSrG=}TJ kNvw} :]Wy9ξMK:o]s/ϼK$Jh M|R6a<֎/s/Jc;iosscZӳi o|w\QƸϤk\&xX=dže8p2b[nJ/<]($+SӴ~%Z9Y2شWmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UWUU_UUU_UUUDUUUUUUUUUUUUUUN??UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPz ee AkP_MjGZ*THU֤UVIEjK5TjGj KUO֪ZZ֠EZZQW/AP_Zj ֠j#Z֫Z?ZO[RREJjjP_I?uPAZ֟*#Wj*5Mj HHH BHI I 8 WfW#?#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???RJ$??F`7 1h!@?u6?u6?u6??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 94PNG  IHDRc IDATxw|\ՙ;E"˽{bcS SLPR6&Ih&d, !4b {{yef4"?=7yS ()(H*͏dBPQQAccp?y2iΓ'UUzhJ0HCC 5{z ;}FѼC) LӰS 0 )%R/_G;馐HgSa_VqIdQ EzH ~N8Ď_o7{dx+yEED``^wPlc(BIALDJKH,l)OD 4)y J/|;=Wۿt0bJQ{|)-"EZ-k&hdLDAn神K@UWmmw|W'QkeFxyl1ƣ))pVkdi"%ńts(>Rr/6`W4M9ߴ-slHiT͈S;~b[!]PHEAU= V5;ۇߛr8q $%4˨A;tNC !x|YP&`%}‘&n쁤bz8ӑz;`Ԡi힫d=<Ҳ(wy?CE.4MJz_*kw xovWlaԠlDBX~7EUW0Ku#Kq}rzaji^2|Y6qkwdWFzvk{]_FVf;vǾ]r=SHPzDn{+dpw~.l F=G 9%kFv вd)OErP`]}\G4k<)T{(.3 =S`mՎ 7U|p^LH1PzR\l)},"7Ʉ4}i)ѣ%imz55TaJU ~/+%z,y4bGq/ŗWTi;& m:ܗݖ &ekWٕ0lG"4±F7 _^yv7&.yx=~EESvs<"q4L&n`= K>d[.[]!#PFꩪC]CAJhd#;kνM#;/ *!nJ40L]˔Q#Lj=<3ƝCnN1/o`>l<͇GKv\uݨ*z-wHD 7K( g#G.v(S 棾Uvd24 '̌2ȥϽV(/-Uҁ#y#=<ف"4G8ڔvJ3rT<¼R^fq~\1Il%w cҳ~ʖk0 U9|emGGUU4K>)ªvp hNiϳJ5ǒgˆS,ǦCvƲeAg[SϝqUR,#^6gy7d Ӡ+Iڕy3Qwo%AK@2l۲j3$3N:Hہ%T,fz\<<ujK/UQx{'xKK-8H$S+QR8|xp 9)%ϸ!l2aI7>zkabzEߊG=jz'nWᦛn|iӦѻwoJKKׯyyyrek!%Cd;<#ZERɗP{8MZ4:R{] z[r݈ЫWLczΟHi]suu5Vq PR04xqg9L3`Lc'?i87H$ kwvpi?]cΛn@)%9YE<%9p]A4)-4 )QL"FE^^` Sܾ(j!'V&h?CG7vittx=<ƯάIAnoIcN~%$j-.s\tG7y~q=$oz`w{|njC._UZ֎3b%Yד(WisGVe9i<K"ǤP{hU_4> 7xckS; #Oq;g;דALTC0IB@pwfg]Jۖ 0[[2۸<^4 H+U?5/S"m膎#z" :*f yfMuM %فvoBJ# ,zǎ|d7+[9*%ϢE[[(BӼlšDIAaBR5BbD_IKI\V6m_r+sOLa'aXıU쒣nx4~_O\lYZJw}1 A~v]Gz~ܐY)4Uko$3'^es^?$߿At]0.\e9NIEͮ¼ҔWn$'xK8mgZH@@7b̜taWZ=y^Kx~N7o|H$hѳ-w:EzSO=uOW$=۱z3prz\4NQ>y ҵ y尣z9|Za$dݫ) ;u@O?Svu{/gpٸxO,)Yi1jWj,xꛪoݟC v$QBaaEESPPGלVL 7 &$w0l:] =oW)K_oWW<ǹ]m˲4<Z?[泀[wq\Lޱn4Ŗk*ҶKiryz̈S9pW8$%=Ssrrx(%Ϸ\Ï%WM;1J~%K[x'\ׂ2V 0P^l⤮LUU|丷s攘;(uT5kjj9.4lw/]v5yƎV><-`„0d!ϔ)SRN}@qbfoީxwc jjjjhll< A `6l0…l޼F?sp,'N䋏f>.rf̘˙={6W^y%A`-AnTEϞkBI2y>m!!غ{WWQYQA}khh4oٺx'7|^~6<\p̙z)Gi0TEe *?az]$TEs5^|>_]i0lϑRՊ(lv>LaĀ)aUneoIENHB8 o*Gb;oٹ%S,[nZ H&\뾮sNɃ칿/m z/2i X 9sf(;mʭX>Job5|K.q,tAjҰgk8/:w̛7>s=}ᇬ]n!s,X3f0en;5"?s ?Tr\0yg8 ;ȫgq}}SQ=" 6չ^Wgҥp ۗK/^z &ŋ[9 Gju K⦛, C3l{س!7UExa[(/Cj829\}%\?i.:u% !H:wk" cύ/ (XMbz$:R[,[gfٲer)1zhN=T&N>z5|8_uѵ dq$Fx< rBm,cHxfNvyǗޝDy:U[H~^:ʼn(nm*\ibϞ!z}deewM)؂SEb7UiGoϞI!b_h8 ;؃[출hBEa5'S- MDq~%))nߙc1[8ݻw5ㄽOjMW8_VvAqlݙ0]-sk]N;L^+6> 7})aXH4Ԣic4/-qLAc֕p4Z}]Ym8UD<_?;(;8ɳw]N%,g۶*~qeEXH,D4攩ml-Bu+Iˬi Ց(;$ٲs z%@Q9B}n݈#'O*Tش#o ZCu4ٷP8e*wcA6kHiv\@7 ϊ+_m #Cukp#?u)4$I3_wHaez{ͯRWx~GuGVxaY˺b [e`l՜`M$OHJDJ=WE/,߹"y]k2 uuɹ6]9;DJ$l3Rۃ{UVr:|AQ\\̝wo駟n ͵Xh;vXzyd/F*R ӟEZNt'NzҦ9CSӇ VaW|1 e7șgɓbLU6Yb?F XKeW'SQMppI8L8B!Нkh 9g֍Qf98|SRRB޽ի >܍x\t)w'-JH 3/͵KHԣ\ !e)G~vo^c"l߾jk… yUKJ.ykhLCydx<1+0l{[?P(I7N-  :FijK,_uQX7c=b+=OFEn Vt W=v~;]<Ïc;:"&Hp$D8dݦyט;w.of'4bOuP''H=FD,xpTVV?*B!B" [vMi;;",:nATECU=:@ϲ0cv{а:yqMb&V*+9sOEU݃8Zxw^yn&O}^]=XЕ< Vϙ37HhV9DӜix4/64Imu+WdʕviߟGyc! ZK Fp Px-|hi8HLK 1L*9"z.]q:$Ϛx>_&0 PoweHiDnw/?e)'Ή㔩q!3#AU4Jϒym!W#H?g^ƃPjs:!q ãy-%g̖cUJNN^cyx< `FR{{_S5fC&BJ7t-R"\tFF#\>/9xW .B|>_ZcPXrzCロEt̯#7n@nHظ1TEݸ CDb!jy}Q_p<=Ft1e-[@NxVV1 _cnH) 4nHxNvמ+ΛsiU$Ú : i6" X eZ(+{ K .LYz92$Xc$9Y֮x#MO?#<(zFBjq 7U0by51l)ݘa3Ѷ}ǔFr>i`~t1qԩL?¼^WR_f۫r] ★],X ->-NEvq)M!7\;־fʠ+< FƤ1'cZ E(Bqk'!JT~YqXM|G!P'i\}n,}Gdg 3[{lj//nxK)%ALq~?~\n2I)2a`VEkKVzt-dez PU4Y4i m[?f5zb0j 1巊I=}^,y%!0Am~k^4 nx׭u,%01 3ފڱ$dYhlsvI(䱿T&; )jXm=?Z{feƸBKWўLTXj`diE ЍX? #ƊO`Im~.YMEe,_,W_| YdggMNn9,e96fo+:]tqt;u/sv =醎?$8r ѳfvH;vU;Ikw#M*kwz. {< `(Q=?xׇOY'>ve:Hk6rܙF ݴH͚th-w"ӗCAnLSõ/lǨNTEh^>!߶9GYN_@.:D48ɞͭj^ݶw["! 5U 6MZ>M>~&MeU9CM@7tL#e0 z6y'%&HXFfy-0[̑uC(T Lu v!^E[nr^P,BQ*vrF ! LօGףTTؾh, 2~p B^"=q3mk*K>v,&B*c*NYЭ9.#bzԉDU -5a$ 4#o R$NU^ sloeEţYoЩm'>;)VDE*BiuGl[Im}b-&UU!n{ђ5Ҵ@ǟO#;뱥^ 01^1X˦- Nu:+V8 [oKOJ)5颤N1#_g3[ Jojs1˜w> 7duH,}[;_ SFA*Ҫ}:^: cͧkۧ-DYQj B7IF11Tjǖ6Чh0}v(ɩӯ$$NT `rfa&tlIβ47< *x;ɷf%Tۇ@:y'iD"MԥѲI}0/uK?]an7dU>_%۴ts 0݋q%ŭ0N|#]IuV,-b蹖ԉDlvV'?XPUј0┃vҒ5U%11W[W2c|jbz:A$[kWBXݴ! ӣDRٽSҭ+0}N4!idO:[Gh`H,DvBU!h ָ+NL)Mm~iǝnDw ,w=uu[m5Q=BL#As҄zhjRG=teKJL$Mz,fMvmKAcuI(܀ϛĴ*dZ]Ιy#o>6s9ػWs@r%xw22.4tQ*.iZw+\:>F]߹H4R%yl0b46TeӺC&ml !زk DHiRJ÷رn4sGfdt8`9Hk;=BNs\J$d^&Bu"t7Ƀ®{3Pw_(-(jT`{úeٶg4% ^kL9 |d͚?u=A>LkLksa-{ZH` t3)@7*h(tꥲv%(͐y3x#N zOv! sƿPkI<4μK\|Yl3gR6:o0vFwϻՓQt#GЍU݈udgeW6=.k׍ȓˍlK)-NanfϚW_~ś=mbԠR5a5ѻhPs03Kٶ?9]'] )Oߢ 07O/j:s: <1#l޵n5%i$ܢe8݆<%e()MWHzo`5|o& EM6T`di=z np(n复Wu|40C' E ×A^(E7?p+YBAsN\dXBy`cp$V`&hF̈s׭oe})z-'hMY0X6k \TŃjx>LT9p~0M/H rwۥaKKʬ\X?${34:˖LZ*kw{~_݈RX2>Aq~9Br *@}W .DzUK;z d T{<@˲hdffha;l&DY-[LNȺdA KVpēg nlS$Q2sutГ8n)|d:|^?DŐ.ΰ1Xӡh ?7H$/mOLRAlSLds^d&4RvM>Xd$!o9Y#Aj%Ź~N]5)%Uuoy0sMx4?CHM T&$+#<%)i7ְc_ _UkK搝%Py)pDs$ Eo" lؕhSq~YZq=x:!Gw/琠1XC4 Hz`2.}[%r4-z]zP]X>Ntbfz1#JS>m{=ާx!<'2-1ܬbPP~_'7e֋ t%," 7)e#B5V#pFcҤOѡ@(2Lk8bs Ă^CB`c6#Phnx!8E$OGcp&зxA=f!DlEdJIENDB`move=1000;blend=1000;3PEIB1^^ ~ ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI PO  m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm $RI"I$! ` 0@$$RB!mmI %$mmI$IHJI$mmmIm6II-M`@$JHDR$I""""mmII$ DRIJmm! DJIm$I%6`m) !B%$6mI$I%mmDJI$I$!l`!D""$JAB-mi $mmI$I III$mmmI6mi"I%ilR$IIDI$DDDSmmi"I$DJI"IAmm!HII6m$`6l %$!BDmI$$Mm0II$$-l0`""HDDDIH!Bmm$$B"mmI$I$ "I)$mmmI&mm$I$`m6mDI)!HI$mmm$I$HII$I( @#mm)I)&m$lm$!BH@Tmi$$`""ImI)$$m  @DRIHI)!BmmHD@Mmi$I$$I%$mmmI$mm$l mb QHI%$")I$Mmm$IB"I)$%mm"I%$m$mm6DB!RIH mm$$lDRI6m``"I%$$B `I"II% !BmmRI mm$I$$$Mmmi$mm$mm D )I$E"I$""")mm$I"DI%$$mBI$mDSmmHB! I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUUUUUUUU*N?gUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPz ee AkP_MjCT?CT?I֪jWiu&_֤?P_Z_U!j [Z iAAZj AP_֠Z/ZBUT_I/RUTo֫֩?¥RO]TVT(CT!R!R"D"@$"D$H"D$D"D$H$8 W WfW#Cꪪ tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??`QK6َ*@?q?q?q??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10,6PNG  IHDRc IDATxw|\ez$˒-1ƍJ!e.K$a R!K@!B` `l1e[VHv[fF*3lȇנ;A@@ aC^SVT Laah躎nܿq1411O*S=ɂca 0sLQ]CΙYdkj+!Or|{BB3E`Œi t]tMWi>N5 5}':03aEr *{}cښᇿ8GuLLPR8 0kZ ]WinP{$m܏nLL$,fDZl-a0MEKR7{[̏9DqA%sQ)tME%@}"kD}Y (#IˮDdi]WIqT5t:X BaZ4-E{1m!v^< ߘ?t5`a,a˸;u9r%z489&Te i=-jVVý{Q5UK)-)֒kS(JwqEo4(TpKxq X³eۄ?2I)q"bt]?ED%KuiY-OnE]z!460&&d?E9n~@uE#`k:{!ݼi1om׌ SLm7bJ Ջxۭ&h\1O&Jp*Kf ^0P`ӱ9eť\eLnC}A҂ccz<ʊj ذQ~Z0O,+2MYEB%0M3ý`콠y&}2Ld: zAX5MI4$QB$D!; .qʋk Q4MS3m-^ ih5aIt;P)  +vPE $QF%DA$11 2cza'*%Ӭfzuǘx,bRmN G }+YzdyhGp ӊEԄ^X'zm+3Mkh: ˱;y݈GA044-.{11r^"hk+#^rťҝC_d1 k509ضss=1cXK㳖%!^0MtCG|L&J ][kB >k9>gn ~ L1~D|߱ X򳘦nh61ʊj\e-A!!LOH\f†{/`Rg1WE*!rp2tC2`^>DLL 4tt Ps,a҄#g߀,y$䱢%<(] #޻l3( gl000u9%/oa9_w c:}cWֵyYkmS2MLSϊtX*&Tx޷x<>*KfIWrCwsw4[x53.Dnj5c`YgᎽyXń +. fMYz>ۡ;s 5 Bkϩ9"3~%ՋxƶWtC: Ӱ4EMREJ [T>``jWtwafma8_|4]!Iz;9 țv5fO_+e5E]vr?щ a,3[YxAE1L7tDa&nmG)Ejh}egq!'(CDnZƦ_~0RnP+P}znr&5JD%iD kjg[ n}k><&KmTZ)%H> ذXr2^߂J__}5@0tT=iY,9#jSOC$`ݲ"MF RjöI8ZhSN|L3Xp<96p0)砕6-xd/i+|ҍtEܭqk*  U^ru)b;ǿ˿߃Yboe09eM"@D$Q XF:x;wl NTǞ鵶{i'[X2d Ew73{qoO3 yTTTpBx (b&S=Eb?iJܷXDC9ِKE[ ឃo5T2n| Bex$+8Mxi+vI'aÆo-78S˂i`}9{NM#@H@7zڥvzҏvD[ SB3A[~ʋĴ򙈂y1f : rU;IRSSW\q[lKCղ ;vL},yeΌ'?q W.)~c(˪qA[WVu /܆1M/A0HW^Ykز+JwzJ%i`^:$9ߢ(aw5u3V)8].bEKHgn3N(;$`*yg*5'H я~x3gVZEcc# pꩧx_1ڳp~_]s5H>0Wp4I/-!j>p?L"C|SEAUtMCShj n [u,

8)5AW}9_O k_{㏳qlաs? I~\+e[B!0pK?,/d&x͞­P( posǯ&6X8km8l.{&fL[nhrd/TX'u Q?O>l޼y}n>G$Q0rOo>,"HH$kRy+ڂ&11k%G5L`X^t5ŵV͵~OPW5H@(G[g3CTWWSYY<---KS 嵷7`f}At]?ޓ9[ɯI BAAT::;?䡻aڻٹh;Z6%c$ %Z: #儃E5v4Yswy'xz>kMPKo}=Н LG \l>G$7-lwN\~&]]]tvuIJIbYXp&wE [[)P:Żu =/lw1zqN4u]>9~i~ àW_}XgWFv5oO/ߛgn+a6_P TǓx+2gM_ƥ^COO7cqzuXT+BzHDuy#زkeOyE_455_=vܼ3HQti?j¡Us37YcؕNO^9 [P\*ݶ&{q<54ݢJ|rKM[[fږ=xwԂs.m^4Ѵ <"E5x=>tMD<0$o?y97w)xEIvHZ UKmqy=~)Lts9|tS=GLuE[e/D@,.fߏi[og|QPݽS[}r$ 3OA2IuU-ERJ1k,ݼ 2C7ܝz9m]~pS һ/\ZT.W<~։Ĩ `wQZ8StHӱpI?r<$Q/&Mvי8d4{/֭-A~{C:2744 GрQ<[ٲ/D;u댘I>A$iIz qg}e O3O{or ˑe.)4p, qUCAJ ).෿ !yH$Gյhh\1k!K5yHA}xz";=^NH?+0Wʷ?N8?*D^|졤*{쿲k2.C"?ޓHǀY/ wG7u|̸_W<:3 :sYgq-6W$-eeGȌ}? <~Ku*T-EG:,ccU$rPK? b]EAJ0 ~wM q22>8BIt]^a7|C0 UK94ݴybgsHMppYi9BsYt~GM8 n/|3\~̞=:pzYf?tC'c90uRUV?{\p牄JPUx=V?`ϡ'oذ w-Z9Mss3?0;wdȲ'$3f?13f̠ ݧ^oYL/%KTk:9̕G?rf?Kpp̭?rG%D;hjJӡ.i>[gS~|9lݺuLձՒCCo׬Y/<}nf~vWIJM|xhWc#gYԸ *'_qpŹ_#i*Da͎Xw`W_Ϸ=P- RY02؝}mQRR·NC h̝wyHG9vgPQ<ꊙK  O^p3>o/@2?/MKnO̮[5_uZ3q&RU~ʄVҐ(;:ҡz'x{7kn&^ ޹kXC #Ij+PQRGyq `EED…PTXX/(XwYL$ں[ gA_,?,z3JԐȿ5#j| _0#|;pc3VECKTJ #a j:d/Ntpi5M/c.$*^%#ΪO7 PUxGp2kV$<`, =LwoU*F<6iyM#R!ם$[ !:uo}}=3gdm<41u G᱈Pڰ6fefZMre3`dN(,fApAxBB%[p,Ek7wy/TnX^Yuu὾c@_Cm0LxsxE-q~`@ W"I2R??$۞۾qǃ͛ʖ-•l޼_uusk(sg:m`%wx"& qṷ?r'mÝMoν[عo+^ĉKaro@]v'k'@pXP&g?pkG_lm۬ w>YN-ryZGiKDޡ[UYZO?Lo7P1_nAkks$ݛ9-_9Eݴ]o ?DE~Y'gj繭qvW^y%{21ekS^3'dfUS.8RN8Ps."42^xN9q_?nv9zf$'^p0Xi?&lޓqiō'` FJO"HЅ2vǽ/ K+.ϯ 7|37ndC`'T~ˀIkga!tIIDAT;G l>6AnS1< gD'KfZwO PJrv7AMKqzK'?29DWcO~2Ƥy8bU~nz?#dhz*Cx=A>@qO}*X[~*Kg&:w{ѢEC0swLĞpj0jPEKK4lvl$RĒ$k~pιP/~1HpEyyIp`r. fo*`aO ¸ M< # kLÄ/4Ĝg֬Y3]taD#2;ah¼U#4O~`1ŻP$'tԓַΧ^#lΩ=aL (r+kXU̫_ŧ?iL@7.~Ŋ{oy GDW\zv j$R}8D }Pu5_,a144fmUSGϚ5k8G=ޱa5Ӹ-1 @I4kNy_p/bY<<0 Dg4]!Ĉ{ncsphLׁ?;Wш₪!ʄϼ|:n}&<5単@wo+z'$}x=~+_ڎ{njbVv3y2kqPl enGEpeewEykD[3vTXvwk;dF+K3vkKґ yո}ʊj'Y4q># ]&owW xSYZ}~_حDNY\Pә% &6+^c&I%;b wGt|&e@V&&Y?x ;Diw| nz=?`w6kIs (IϮjro;Ƹd/F-gw}|&A(+aEHN 9*ͪn01pg !#t76Zg,pʁ& ׯq`+k- TjlגAxd/ly~;zl/f d1>^Y:w=IG3 dB4m+(j+iDVևlnEULT5IgtG3j*PZXCU}}$}Y?H]]+'T5I"uK]j]GE_cڷ #5`MXu\@4N_NF=ǣ'Sڗt`:BK/>:$Q7E_@DGgD B鸋-H` }~[q=>囹*RJhoQ)8bJMLHb$R1,t[T7m>%0Ma^ys,'iLO;Yҕͥb睎'~ dX0 [ j pw&Z:=L2' ozռqsanJ%芶eDZ ?O3S(Zs%U(jypJ7"eE5@F=`׈DۉwM{4aM7cM)q7ALƇ2pX'd+ͭ-xϲr¢sEEM1!8H 'aݼH@!Ů<@ZLÁ?1v ]W%{{jf(Hbyo023+H>;(gn>^H9>oٺ,P|2V.n9U% H"Gf:{tQǶszȒ1j![K,ɮEQPWV\< Ua MS': QޕȒ- {[ i_ G"*+oIxdVފ+s}0? CH"=/81At2^OPol2EQz}x=>^ץ^y#IF"aQ`?"a6|;^pY1:0 N|̟gƴ!A$da̞\+A 71k2aXkDEDDdYj^;nT*' )G\X>t^rp=돻ĵP)(I=݅q-[n"yp4Ьu7>h /1@2GoBvYfesN̩6޺\|:zf6 fA% CdPVT;~YTK8`Մuuw=# Ձ`:a*-H[wx"HTdL"q@gAyǂݝtwuIWw'=#Wd_* h)f8 NkXek&MTaf?ޓ|v*X:d^K(I6hʛ(7[K K^ںI*q]Oί*G$StHh[N(xIIENDB`move=1000;blend=1000;3PEIB1^^ ~ ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI PO  m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm $RI"I$! ` 0@$$RB!mmI %$mmI$IHJI$mmmIm6II-M`@$JHDR$I""""mmII$ DRIJmm! DJIm$I%6`m) !B%$6mI$I%mmDJI$I$!l`!D""$JAB-mi $mmI$I III$mmmI6mi"I%ilR$IIDI$DDDSmmi"I$DJI"IAmm!HII6m$`6l %$!BDmI$$Mm0II$$-l0`""HDDDIH!Bmm$$B"mmI$I$ "I)$mmmI&mm$I$`m6mDI)!HI$mmm$I$HII$I( @#mm)I)&m$lm$!BH@Tmi$$`""ImI)$$m  @DRIHI)!BmmHD@Mmi$I$$I%$mmmI$mm$l mb QHI%$")I$Mmm$IB"I)$%mm"I%$m$mm6DB!RIH mm$$lDRI6m``"I%$$B `I"II% !BmmRI mm$I$$$Mmmi$mm$mm D )I$E"I$""")mm$I"DI%$$mBI$mDSmmHB! I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1̃̃1GYTT8 H&& H&`b>eeCURZ&I_jjORTQIRkQDZQ'?RkkTTQ֫TIjOԚ&GURZ&IEjGԟ֤IRkWZZԟ5Mu(U֪?֤'jMmj]j#?IZ[ZZ_jjOR֤֩5֨?WZZԟ5Mu(U֪?֤'EԚ&GA$ BI!$HB $!IA$ BI!$ ] \mp fJJUTUJ$URI%UZU$!UZUUATJUUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVUTJ!UI$IZURI*J UUUU*! UUUU* IP5UUUUUUJUUURMUSUU*$JI$IUUP!BTI$%U$UUT*I$UT$I*PBTUUI$TTjUI$$U&URI%UTIUjTP!UjUUURI*UTIU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U%U%ZURI*!U$U&VUUI$I*!RIBUUTAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$T! *UUJIP! $*U5UJI%UTIUVUI%UUjUUURI*UTIjU$IUUI$I*!CUUUUJI$UUU$UI$$UUT%ZBUUJI%U$!BJUURT!BI$JUMUTIUU$UURIBUUTUTJ!Uj$jUI$UURI$J!BUUURI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*H U@UTH $ UUUJIBUUTATJ!Uj$jUI$UURI$J!BUUUJI$UUI*%Uj!RI%jI$UUUJIVUURI$UUU*I%B*JUTUJ$URI%UZU$!UZUUAUI$BVRI&TI%UU$I$B! UUUU*I$IUUTUVB$VTKUUUTj! JUU*$TTjUI$I$MUUMUTIUU$IPVUI%BVUPAU$jZI$RI$UTI$B5UUUT$I%UURJIUZ!TIZRI-UUURU**UUTI*!BUU$BRI%RUjUTJ$UUUTJ*UUUT*I%BUUUUUU*UUUJI5UUUTI*$I%UUB!jRI$JTUUPB$URZ$UAURUVUI$UUU*I%AU$A@AUTIAA$P@RIBUUTAUI$ UUUUUUTUUU*I$UUUTI$I$UUB!I$I*URJUUABJUJIjU!UIUZTIUIUIVU_rvbinding site for residue zn a 600ac11vbinding site for residue zn a 601ac2`1~binding site for residue co3 a 700ac3`c| 1vbinding site for residue zn b 600ac41vbinding site for residue zn b 601ac5`1~binding site for residue co3 b 700ac6ad| 1vbinding site for residue cl z 1ec1JJ1vbinding site for residue zn c 600ac71vbinding site for residue zn c 601ac8`1~binding site for residue co3 c 700ac9ad| 1vbinding site for residue zn d 600bc11vbinding site for residue zn d 601bc2`1~binding site for residue co3 d 700bc3ad| 1vbinding site for residue zn e 600bc41vbinding site for residue zn e 601bc5`1~binding site for residue co3 e 700bc6ad| 1vbinding site for residue zn f 600bc71vbinding site for residue zn f 601bc8`1~binding site for residue co3 f 700bc9`c| 1vbinding site for residue zn g 600cc11vbinding site for residue zn g 601cc2`1~binding site for residue co3 g 700cc3ad| 1vbinding site for residue zn h 600cc41vbinding site for residue zn h 601cc5`1~binding site for residue co3 h 700cc6ad| 1vbinding site for residue zn i 600cc71vbinding site for residue zn i 601cc8`1~binding site for residue co3 i 700cc9ad| 1vbinding site for residue zn j 600dc11 vbinding site for residue zn j 601dc2`1 ~binding site for residue co3 j 700dc3ad| 1 vbinding site for residue zn k 600dc41 vbinding site for residue zn k 601dc5`1 ~binding site for residue co3 k 700dc6ad| 1 vbinding site for residue zn l 600dc71 vbinding site for residue zn l 601dc8`1 ~binding site for residue co3 l 700dc9ad| 1 vbinding site for residue cl z 2ec2JJ1 3PEIN" UUUUUUUUUUUUUUUUUUUUUUWN<UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPz ee AkP_MjGZ֩jԟj֩?֗WRkUjG**GP_Z_U#u(֟ZA(RkP_֠Z/Z֪?֠jOA֫UTZO]i(*R Q-iGQQUSZkTHHHHBBB@BHHHHHHHI8 WWpWfW#?<"? tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???zr$??`;P~6Q2@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11'3PNG  IHDRc IDATxwu2mgfwͦlzOH Ppᩜ?<O;TB JB B &ٚӾ[ff{قz Y!ry lQ?`/+< @d떿H IHȒ,)Ȓ((–VCB1"V -hBoh;x޽c膆a·-_mEcD,!I22 $f5#|t#aFB ࢅW*zDaeE3  CC75t=э-i0!/YRFP`BXsK IHϱ!1']O RV420LGwHk]P:ݛ) N pk46VuŘy4-Y(?%ni86  $əI=sx也^-ugMY1M$R3.1mscaoZ&i/J&;#䙎@Z3cxeaY&>5~ұF/HHm800 }c i(,Ái4Վp6/@~YVPdIOŌ>TJIHNiXmu#ڶbzoz7PCUd6YV<L'|~abL/P+pB%D-#`mqȪ^ppۈ699!vx+0 ƘlYiT51Eq>@ei[qCxiNCMGi=a4dgHcVv-r$hmo6ecxX}3>p:c {eYeb97tg`ZW3]vW,Ȳ WIcihdcx-^Uw+_k"s._yS舶؎f%S-r6 &~rU9mO/oi3w8͗~Gv܍%,Ϥ}Qk\ x2P; G۽LwNE3/0ɗK,YVd٦2[~]iBdU ,[9y)%V5g80ʍl`xN{%*Jc_}*~~i7^5Wz2fIkQ,aј6yaTyX}3$^abZ&%Άr0-0 X3O)̞3ܜ"$lSd xX}3@Gbb wczS4W4V܈eYM7 HXsG 2pI"caN;S$IhL Db=3E 6bhzh K61# +Tĵg47VWz&enI %ؙ|>e8=k%og_yȲ;v#%AvH€D$2*;ڹǙ^ׂ`0nL$3p=V?fbm4W8lZYa}7]vN\\9~[eb3S*.hs.U񻧿{e @.8xH7gؠĴnFH=ؙ}ށ&.J^02,'Ƒт(*$Ȫ/.EAט=Bo xь?xWϳry0Mww U/ (/+. 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'O^'EjIG7y)e34fuYUX@Q1n:%̜WN*wQ p(!V,`$W*I$0_REQx$Y4 F-r>롙aͨ?]wV܈$}a+MݚTP]{k/dIIw!xɮLm<(.5 `X}hTp$S")PfӏaȦmz% ;C2dEC,oeƤ P>xէ$IhF|Ԩdx$$zIeW7eUydj"EkrJi;yGb}:2$[J|c>np?.Yv<0Y[EVGGdνv(-CdY7r[ )-#[GpLi ̝)-?@YV躁()(AGD ,{n~Yqz;9Bs{ rՕA_'Ⱥ9/\pdz ,qɑT/-O<;4եԹDMQRP$۴ڟnM~3y_Z7K?r{Ȕ'7 d u>OW8` ,˶?'6I!=ϱי>i f|jiio`Y_Fcƶ:TRZS'{dzд@ d445Gkjs;.teabZ ͧYh /H H%̌p2Q!5.!kKNFĐ.#;q_; &PQ:q4gi@`OV*Fiνу` Lssf/ Bs^TliEUyٯɛ "Zו] EVŢDGioo+C'w;" iM^N1tΆn)B 31*K(15kx ' Pd݉yAVμ4Zh3-ĵ(fK;v6a_MCa Hq.gY:g,[Oe/a^8\3uZeœ8@sV>t]XDGDZT]IENDB`move=1000;blend=1000;3PEIB1^^ ~ ee B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI B֡PRkRPTT֤UVI֫꺓ZR//U?ZjZB?_PTZ֡P_Z__ ֨( ֪j_'֡֫UTZTWUVTAUSZkT$H"$H @@"H"DH"D"H"DI PO  m]\UB!p f$II![0`DE$$$B! mmHI)$DmmI$HDRI&mmmMmHImm"$RB"$ImmHI$"$HP@Fml!R$RMi"I) mII!B$)$mI"I-,DE$mm $RI"I$! ` 0@$$RB!mmI %$mmI$IHJI$mmmIm6II-M`@$JHDR$I""""mmII$ DRIJmm! DJIm$I%6`m) !B%$6mI$I%mmDJI$I$!l`!D""$JAB-mi $mmI$I III$mmmI6mi"I%ilR$IIDI$DDDSmmi"I$DJI"IAmm!HII6m$`6l %$!BDmI$$Mm0II$$-l0`""HDDDIH!Bmm$$B"mmI$I$ "I)$mmmI&mm$I$`m6mDI)!HI$mmm$I$HII$I( @#mm)I)&m$lm$!BH@Tmi$$`""ImI)$$m  @DRIHI)!BmmHD@Mmi$I$$I%$mmmI$mm$l mb QHI%$")I$Mmm$IB"I)$%mm"I%$m$mm6DB!RIH mm$$lDRI6m``"I%$$B `I"II% !BmmRI mm$I$$$Mmmi$mm$mm D )I$E"I$""")mm$I"DI%$$mBI$mDSmmHB! I"RISmmD[mXI&ml ?|;tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue cl a 496ac6=U1~binding site for residue edo a 502bc2Mk 1~binding site for residue edo a 504bc4_ 1vbinding site for residue fmt a 509bc91vbinding site for residue edo a 510cc1ru1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESdd1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k a 490ac11 vbinding site for residue peg a 492ac31 tbinding site for residue k a 497ac71 vbinding site for residue fmt a 500ac9a1 ubinding site for residue cl a 505bc51 ~binding site for residue edo a 507bc7r 1 ~binding site for residue peg a 508bc8 1 vbinding site for residue edo a 512cc3PS1 vbinding site for residue so4 a 513cc41 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 met->mse selenomethionine MOD_RES1 ubinding site for residue cl a 496ac6=U1!~binding site for residue edo a 502bc2Mk 1!~binding site for residue edo a 504bc4_ 1!vbinding site for residue fmt a 509bc91!vbinding site for residue edo a 510cc1ru1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES 1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES..1!met->mse selenomethionine MOD_RESYY1!met->mse selenomethionine MOD_RESdd1!met->mse selenomethionine MOD_RES1!met->mse selenomethionine MOD_RES1!tbinding site for residue k a 490ac11vbinding site for residue peg a 492ac31tbinding site for residue k a 497ac71vbinding site for residue fmt a 500ac9a1ubinding site for residue cl a 505bc51~binding site for residue edo a 507bc7r 1~binding site for residue peg a 508bc8 1vbinding site for residue edo a 512cc3PS1vbinding site for residue so4 a 513cc41met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1