1)3.6-1h /data/swissprot/ 3LAC.pdbdupa 1AUG.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Bacillus Anthracis Pyrrolidone- Carboxylate Peptidase, Pcp[/h3] [p]S.M.Anderson, Z.Wawrzak, O.Onopriyenko, J.Hasseman, A.Edwards, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3LAC" target="blank"]3LAC[/a] [small](deposited on 06-JAN-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1AUG.pdb3LAC a_3LACB1  1AUG3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F 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218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???{s$??@3C'LGQ@?@;?@;?@;??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBiological unitiGPNG  IHDRc IDATxu|ςnT +]!(*(HIItJ~'$c|>?}9q!݁olO|B8o.. 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W6OlgɋPZ"c9\lLWWy476[^0ƦI󉝤TKmyqd,:ye-Qu g .;a%rߓq>aj$́*` ĨzZ$ E %.(];7QL!IDAT7Xʤ=a:í) `-ٗ6BY_pڤZ6S¶`Ԇ75hXz0&(-Kds*S(\(7`ꭔ@I-R@\Xlr}ʠIyOuQ1sk*XjBQc0h鞏Hu;Ū :p9VO~փٮA)~^'Sgr=5dmY!b-H\bTlȣ"K?c\I m)p8Q#.X M,J|7PZcnШpH?.Ԟz;P ۝LZzuur{T1?bGH=I5\WE1ęrIw$hD4؆Z2QVmfM#&Stp1|.kw r؎폮ԱZ^pLxzVf)~$ 8cF YiC(/Vc[S"zn ;u 6Ci 8s%1Aܸ؂#+ǽu}, `t,tnkt nn$|.T`<~5k(w%KqKl"s'G|BGʬ|"[F߄cA3vtΠX #F(nv٩VZNYYE=TFcuZ9k8$a ġ)lD[n<:R~T l׷GJE+1)AGi a[ZPܪւwOԕ.@ǡeYK[5h\4Nxq/O Wd_Ճ_ GvCIQ\^gNՆX+< xg܏y|ޓzƺqLWW-R]F/ AqKCW W.;F4 Q+/fg!Cw[:[z)YM<wʀ׳z"Pݳ>=hy5 /(`4hd3 g F( &Q@6Mmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y3LAC  ϗS| AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D" B fDDDDUUI$JI$I%DDDEUDDQUAUUUUUI$I%QTI$I!U$UUI$I$IUUU$I%QU$I$J""*I$J"*$I$B"""*I$I$I$_Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ss$??i7@K@`5R@?`X?`X?X??@@@x@x@ ???333333?333333???#~j????333333? 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((ݻ&.oRkjuBcdlՒhuu5vSQϚ5?G 2nܗnj5cERTt]YA*†зlq&z|/ \޿Ym:VaƵzRhufر_b1;j()q4]}?ՈWJ?Or3ΔjSZH(3BwNɩnc"jkϾ-V7 !\uW{ڍTH]jo%?+JJ~ >6&M~2PZZ^ÔLl aBC$!{$Iщ$$Zj{YNXLg>:C[DyBC:g=h#u> 7lx/ͫuy:= 䑓؁GdPVwL11 D-UU"+ 1!PY2g;HeX,m?Rzcȑ S|v% ;FVÆ}N՞(*]l֑gwURD'()y!L_㲭f_LxtykhFXpe/ӥu )*ڍ_tYnNB,rs22ID{#&SiivwrJe`]Y@lXNv0ԩ%$6[%*UA?h5{[̼}f׮|!YY1 ^S/:wmd36-oP(P4NA'aj򼼆Q]C="ŀs0Y5=Vk)WGX0 Gc9VcL-ZT@IޅBpا"Iyj$9ee{1N-f2}M^obi=\z!|y1B\lM-UOc;rGޯ4n1e JGmy:HNonc҇ ٴ&}:juP?BdۏbhxڵRyx{"IN.}4diy BCb6a4?Bxv^G``sIHZk%vdr9xfkL.W5V $IۛU#k9o#"Q\7RHyyw6 $hv4[p=$5}""/?T*F6]V)烙3)*-]G;k̈́B Mn7o_u慧q7ܰI{bϞ]x=?3sƋm_xF˯+$? CDQQ.[~JB`4eVy.nNOG)hS CIIJhhg`ܳ>]wjǎvp h>=mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y3LAC   UUUUUUAUUUUUUUU_ϗS| AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D"  ` ,HI4ɏ (%L5( BSLa@ Xrj hhiz6ei9=%d.Ӎ u^m$"$^fOueE[$@`,(90㮞dÏ\zZ-@<@`8RE`HHZ(M5a,D evI'=eL0&,ꜪG0Ƀ$E'X n8hɆI,+˕5ʖ,0Dr,`N01S,\D@I0<B2rURT@ˮ8pAU\Y*먺.Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???Dz$=? 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d_ywwyw·Z5|֚/;flaއs߽ǿO\UkMIENDB`move=1000;blend=1000;3LACB1(+g)F<g)Fm6| AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D"CjOT!P!P_֪g/֩P_֠jRխAZP_/jj֭iA$H$D"D @"D"D"DH"'AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D"!OB fDDDDUUI$JI$I%DDDEUDDQUAUUUUUI$I%QTI$I!U$UUI$I$IUUU$I%QU$I$J""*I$J"*$I$B"""*I$I$I$_UU$I**""""I$I$UDEUUUUUTDU$I$DDURI$I$!TDDDTIUU$$I%TDDDEUTI$DTDDDETI$I*"""*"" I$I*I$IB$I$I$IDDDEUTI$$I$TDDDUTDETUUUUQTI$UUI$I$QRI%UTHI$QURI$UQRI$I$"**"$I$""I$I$! """J$I$I%vbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y3LAC   $* $I$I$I$I$I$I$I$Jϗ *   || F`: D01 rHJF6*ZjE:$ctBÂ/DI$.dɔNIQi2xM3<c2&֙dYJՕjћu*fb%ljS3XUR`M4cMMU#H9$G 9NDlLǗ2$($HOFeVıꦒjyMV&Ҕw:pױ6E#,iTQԫJ58yFFHUTUI8Iye3$$0D4*\""Dr䌙2Hy*IiVth躬1M1L75)\$:ËⵋJa17{+GEv))gkZ*իcEQvzktN(wm[=ڴ﮼Ԗm^SJvűb'+p€ v\\_>< x @b;w[];;rԣSWyu;gi#o S iv٣o9ӱkulvnF)H82=ljHxw}OZ~;. 9ů-fWo{o4w@.D1F;0 DxR2-ߧ ZVfbFK=yԗ-KZwmot]vֶou*;43JB|>gx^Sy] 7Zŷ+?=8n)L`DѬsխ̋V[.,8!GCCAЩl6 6 CCECBC`pkV6"-7k3tl wvz7sx}wvgn;)Bޠ"v4kշ{xm(&LHjՍ \ l g}  B!umX'cGy7r~h9eVŬ20cM$UɦUD*ȲVU%Xd"*ydyqK <#84 @tA@t@(TdxnX;7_qN|!P@@& su9I1 (PB %ˢdESQD p,W @!~>)jN֯TW)n}IWsmI+g}yپ5lۨ2ʦʰpMbic$S[ֵaqCn7Lx1Dllgv7˷kryKPJzm;Jvյ=ImJ .Su3c8NDi/ڼ%)j' ߻]L[ޯ oz#ydžS~؜#syu 孋Q/Z5UۇckkLҘQQKS;{R >8NP誈(SUr @.#wO{֣͂k 2Ʋ|佛-Rj >yBZzpkR9J>VC[6_V~; E496"uF xqȱub,D6 ֱNֵ{9^z ނkW YHAj-QB޹/>kfE,Z"ibTQetqh*k,j\5oBr5{I iSV رSViRŔQCM T EC*B!Js} [i$! BM5îJzSO@˂>P ,ihBH jUŐR|ҥf<՚K(fiTj -P.x*lE IIowO]b4))Ծ*D2eHCe "* @ؠtBIRu@PZ(Q,ibAH(TX^]ZTgh U뒒A,Јl4 \ YF l+Uyl@1p|K(,2#H> 4faqePHT8Qp6vE!n)O8-SVH̨ ^/|iNKozHxuc-ھ^j))+wb׷n)]V",@dLPqFؙf 0L3&`f 0L3 PJ`f 0L3 &`0Lf &`?  ` ,HI4ɏ (%L5( BSLa@ Xrj hhiz6ei9=%d.Ӎ u^m$"$^fOueE[$@`,(90㮞dÏ\zZ-@<@`8RE`HHZ(M5a,D evI'=eL0&,ꜪG0Ƀ$E'X n8hɆI,+˕5ʖ,0Dr,`N01S,\D@I0<B2rURT@ˮ8pAU\Y*먺.Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???&$=?S@`Q d7@?|?|?D??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition+PNG  IHDRc IDATxw|TUƿNBGƮ2Z(**ba-kaWWE `ł ҂;6,(ҤϜϹI23 @t2s=y=`H!ZH"EjyR5RIH'Z#EjyR5RIH.ΎE!E` 8yNKZvt~78 h\+RHIQ@D".*8zh2qu[U lҁ@&{'C) 8|S%@ktGM:E.KʐoԤI"O85WAD>/88ht* X ksÀc=] ~ 1pI=V"EqpVwX]ιH(ߩݦyp*| Q둒B۳`9 y]? `oXökfIF`xuǷM-e穂}|>⼨u1G+㺫0;-fQ! =x[C;<';݀sgoIQ@"O6q̓ףEjvfPj %GMnmH`4e.\q}$>:qa‘<89(%d )/,m0! :9ћn4v+/Os'RAJiS%Ow|@)Pb 5R4)z_< ^tڔ%; <3&@!qcr7MEEl--Ce< F#ƈ<@_cЈ;_<<>qh;83 82A>*B7eȉ iI-HF `wKhaC8+ \^ ?UϠV+ /]#Ub628W'Rc 2Gݩ$@3pQLfchڴ)u 7 Xxl+o/rU,e9Q)(аGPG F}ms}XsuQ ÀIugjTq4 2m0>4q{A\0W M A(c [}%RJKJX|fHM peVj l`hP1Xr}sҿ;k}O#"b𙌃ϖf \~y?nR1K0N1/dʎ71<Ɏh+h :5! :8v4.퍑PV&G3|ZCt x?Hh0䁐1/79xw7] ฮ6ao< O@Ф];oϯOf&Y[Ĺ!AqFh֤ ڵ~X0AW|qpڕV>wQ67,EtXzoRRGhPlXt3|@80rQWY,A )~ XӾ[^/lbQt!Fc Fr Azsp07dK~ PW |ϘEyQ9 JyLd,~#bqhEn٪9tJK)Yph07@SXrt2]rJ)B.( cpg!VGq~>tFr%8/PGQv@.<:P=նrNMLrvۍ?wgQTZJQI `by{aa8JK<[jBez2M!oPjpݿCQ~8)DN6#ڊH)_=GO;-y^B=L3DLǡqFטegK~=?'Ja~@%uIKĒ7 J9yp:ހ:gTAeVDv"M gc Ǻ}r47`"YVzroCa$ foRʪ[0tBeoKf~177[2ڴ1</L?澰rf/|* `~rm[M|R0Lp=f!` 0 S0܀03 a]`x?W;1$= R4nj/l9ߝWLyy95ŵ(+h)b$I R9ʐ֢W\X{`Gp ]0.Pz`Pt=PީadxQ!$, H̎zzNg$uUEq^)zY%%%ٴIoQ( Ly@vXuGPؿgc&c74/JG&`abA2GhLDtxj΁2 .9E_[< Xz ʯuf~ކ~Üu.@[+U7.R"U)!~^6%L  >L$QsU7]$=_ p>rp>t5uѻnm腲 հ%@r*P2Q^% R畠O,r A*Id`"[p{p}VL|ԨMxvcp`ڼ>dRPy:LX^PM=8SFo#j bU[y .ϲ;oy~(-!ɳ}v8c}6dׁw`5"M JZ6xBͣGg_$b[ed`E'C~xhW:L`ɽ +v_= NWVpf:gj^IQS(]msӁu`L neO nM),.dQ=۾=S,ᲳQ)n|M'E 4oNn}ރ+e;rΝH B~mH"Q 5EQʻ/F6;5{j0M*NDI;yFkKX F>-OF9gD&X: mu]y nDJRbBcq[OR= ԭ^XQcBnLͩ}-vn+> ?=S HmZ- }A"*Ƙ}L|$]Ug-gpO(%*RPfÈ_sA:C.! 2(׹{x|\tMm9( {΄}HY=n?P0fcp]}e(`ծ4vv/C²1=~+\^ZڴI8>Lz3H]m9Cxءyj7ч C ^ԝehx@Wk068d2_֬jr61x3ʖM+xX)n{>dCOesAT":1Szq {~Lr s dd(4b9<[R"F, ?X5n@+e!SY漽%mɆUCH7h -֭)#C (i%l=7cE4uKMjU.6aBhw`pv2zSeԔiwĈDX+@fElqCk"zd݌>;jk\qb_)ͩ`*ԯ4$: Us B| yXTpTS5M#[@ S<=@&<0L-n>uzbJYIr_Υ5߻~-ޛ{}q%C_3%M΍ w!;;Hra> =uFd :z0Nq*N1ѐGh/ d]C:O<47ࣉҁ®鱦lBz7ha.j Dو]Wy-9}Gχ/#JJxLۦ!ĉJdC,@cXuEخ4+ N#2(󸉛8P_􆷁!5r]:| I"HLg"`[MF.bD\duxZN|7@4$2.,B 'Eu0y.|{ N2UkCJEB'2ӟ}>18/~XXsLy$M8;E'U?259>$<-`B #1|a"-9S&bxkT_ 31Ӓؾs7V<4Kfms w# ӑ<}``%Ef7F|~jXݪ0R Q2 yk(>$;筦z^D[ KX eĴ_Մw[TLu]f@pNuYo ʪΣrU)C#FjmܥM"a PEM|"k.%Ct[;d/+pop\o&'k oرh^ռ3PW CE(\6*Uv?^jvbXhnOF8|HXƶ@}'ݮ&dl(3p;كyH>D_1cڋ,,BWC|W8 v>Ox/"whjxa%h0Q"Qc]#u`N*y. /Cg)ҮHRP"j=_dڟ4L"ǁ< A kuxqt=Ҭ`]N=CuIZBq7ف$'-O֝ N'X")PR5w+@10 @ \jDzؤn%5 P z3 I<ᗣaӇs }]}qƮho7O {GG8b$\z!#8 - 2DY:]4 9OnC2AkoD=;l"rrI#O#VTtH'-:q86e0 _G'9n<.h1Ɓ(ZLƠUj {4/ݗ^xg=cXW8&! 5"iI1JrD~phhUS{Zc?@ WN ʐט8Wb[UmPh6[&T(CJE#g\60sŽ3̿p .`a s$|׭t_^ k@~my(a]ٳ`9 Pc;̙/lJzB>[J1P#F:814A`Wӕ+F =f@ _]"Yz燭KsH5ծ. U5T)P>.E1$wVoD6VVM,n0'^=E/D$@tԅg'8 Y p)N,ŭ2׫gư:=oLt7cM {'9û1RLt31Wf<0<k `_z0S)m+ 0^|XKtp̪d`ʊ.4})B|J9f/$vsNñc UDH!pD6=KWq/ɉ」Utj;vz98Ae,95–'\TTĖf&"z7] n?S(u^whO ILR`Va^ \̍Ea8ٶ0W=2:]$u·1>YϹ 0 of0$jxf]nШo<f?*t/6 o'XTy3W1|8&ù3MHn`>"D׌(SkbB( ODH7YpTu[Qn]#PJ%.Ilwv] & {IDATvȲB9HFpm7,lTǘ "fXapo2 ށ"7F`+bwo-- Zg!vY3t]1|??-j11qRJ_+D81E$63a)`&ٚP.k6y”;+A#1coơ97&) QbwrQ=B^sχ{R./ `5̛u"~X N0l8̄|&p-tp`pɎ2Rt #@&wX}Toi-5,ep+CaeL*tA1Hw`q+ ˓[؏J#gspQh"\Is9MOyD@{KX爝aˀ`{@G)Q(k`3NspY/ p!n8P+;8 a8<Ñ|j43L>{`Luvn}pYuYn6 1~ רt1/ll5_OO` b`?0: `x7ִYѤ; /mFC^q;&*0܋ @|z`x^'kcf2`>:wܒ'95$gQfA/u(&""D8C6JF4ˣWZֳ ?׏Ȯ@:zO$Pcpl8ۏ?y T=5Qf:D1(g+$K4rH-_KEGa0FS>=f#L#9" 0_?\kwFZyyYԬ3MH0jR:LԈU]v~?iɻB,p׭(AMsyDșjAsܒv9 \dR3mBJ+ײӐW(!y8Mhx@øz39=3SVUý))@غO'kSF/.#/:m胤7ؑNF/Pz&pMNx\dRs|h} 'cx99նQ@Wsn)(l{a61a6fezr>vkwB\u[fr;Eڶ5k33 bx+r]31F SцEjc73dؽs3(N@s0kqveXueLE_[&+(YN 4kތr Y"PXb+1,`kd#89:> x.dd=iV{TgY&9ĘE [D8?e]C{c,X4sgqVKY29}mS5I ]@CqHi ##ț:=%ډO7Alw~XJ߶2=* YʗkF(~ϯQΜ<#mw˂ OZÃHƵ1 l/@h ۝%be D b9>B6"/3yd7eDc5w> ,iAVo~ };Y_Ai0r{,M1<{1|L.@?Uy<:D[U >П~bïmh>uMr'^#׮e҆]h;a+:T}@&XXfbc $5FŸgXwHXr K@-4-X5%Y_ʟ-[?2Կρ Xf+>Z ]ьt'o!;bw~7[VTNq CQLv"膼9JB N:IXALx$~b ۵e4 TdQ@ |JuCMFy aB%1CcDQCR<Y9E oʪ9֦R}_'~nl@o=H/O7,6&D4DfxB-^q;I)FuQu8U+xyv1{g/!3 `(TX؆Ba%ڵ:ʛFX7f\#؎H?Gƾ(.AKAT)ĉU^s,W}})IJ u/\]!I&аt#ԷP0Na}vN$Z9"0Q/䙀: H΁z!<|3/^Apܔih7lXkup l)xy6an#ttRip7LAnlĜ4t)$F4Y rΏ~] ;'naGTĠ" G KMaED߀~r,5H;ymse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUGu?[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC   ϗ *   || F`: D01 rHJF6*ZjE:$ctBÂ/DI$.dɔNIQi2xM3<c2&֙dYJՕjћu*fb%ljS3XUR`M4cMMU#H9$G 9NDlLǗ2$($HOFeVıꦒjyMV&Ҕw:pױ6E#,iTQԫJ58yFFHUTUI8Iye3$$0D4*\""Dr䌙2Hy*IiVth躬1M1L75)\$:ËⵋJa17{+GEv))gkZ*իcEQvzktN(wm[=ڴ﮼Ԗm^SJvűb'+p€ v\\_>< x @b;w[];;rԣSWyu;gi#o S iv٣o9ӱkulvnF)H82=ljHxw}OZ~;. 9ů-fWo{o4w@.D1F;0 DxR2-ߧ ZVfbFK=yԗ-KZwmot]vֶou*;43JB|>gx^Sy] 7Zŷ+?=8n)L`DѬsխ̋V[.,8!GCCAЩl6 6 CCECBC`pkV6"-7k3tl wvz7sx}wvgn;)Bޠ"v4kշ{xm(&LHjՍ \ l g}  B!umX'cGy7r~h9eVŬ20cM$UɦUD*ȲVU%Xd"*ydyqK <#84 @tA@t@(TdxnX;7_qN|!P@@& su9I1 (PB %ˢdESQD p,W @!~>)jN֯TW)n}IWsmI+g}yپ5lۨ2ʦʰpMbic$S[ֵaqCn7Lx1Dllgv7˷kryKPJzm;Jvյ=ImJ .Su3c8NDi/ڼ%)j' ߻]L[ޯ oz#ydžS~؜#syu 孋Q/Z5UۇckkLҘQQKS;{R >8NP誈(SUr @.#wO{֣͂k 2Ʋ|佛-Rj >yBZzpkR9J>VC[6_V~; E496"uF xqȱub,D6 ֱNֵ{9^z ނkW YHAj-QB޹/>kfE,Z"ibTQetqh*k,j\5oBr5{I iSV رSViRŔQCM T EC*B!Js} [i$! BM5îJzSO@˂>P ,ihBH jUŐR|ҥf<՚K(fiTj -P.x*lE IIowO]b4))Ծ*D2eHCe "* @ؠtBIRu@PZ(Q,ibAH(TX^]ZTgh U뒒A,Јl4 \ YF l+Uyl@1p|K(,2#H> 4faqePHT8Qp6vE!n)O8-SVH̨ ^/|iNKozHxuc-ھ^j))+wb׷n)]V",@dLPqFؙf 0L3&`f 0L3 PJ`f 0L3 &`0Lf &`?   44UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU4P@  PAM&,h Pa2cE$A *hy3 $4$P,¡`q0i3J &Xq@qQq'*Hd**iǜDʏmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+1AUGAfffL?p}7+3LACAfff333?p}2?vv$??i7@K@`5R@?`X?`X?X??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11PNG  IHDRc IDATxwx[y{K8$jږ-Gގ3ԎISN4ms;Imnx[l%R$6p$D ʒ*=y|;;x}nb7>Ks[Yʳ}s݄Dg\>MKUyF a*B5~eGd.^fI*J=^Z-Vm{/ E`0-ח<ŘI(., 7 @\ٵ曼sgwR<-ҧKו^zqc,ig5ŏ!krA+|߽ϔre,u"l{ Q4PYKAprrfo=wyA-]'3]keQ~R-gey :ytAm,xRFw~k5FEEJs+4"gßZJ=i5*KFy}eQϑ YwEmʬm9Asʻ<֏ D?,*KByT| Jt4YTHIyevW#ξn?N(rIZOUtY[=p.MY"3ebjaփ~(  WǎU/,-*Kb'1*KEdQ[XYYatz s ~XN2ehJFLJRˤl]0K5\͞dhU]ۏޠC $F/QU%hwKU^w眮DQ[ 1*D~3bk?a3/w^v_c_@B"ֶDX f Ąe$u`35p/Q~J`3o|XG Lua,@FJrW!I1z'Q& ME*H\xn^sE Y>EZE78{mUyeyxxzF^afBj7"Cw ,lj+""A&uI愿o8cI]i6[7d_^A (r=vʼiVdoFQiH]n!oeN 6o~^/X4A7\I5Gi9zc~ܼcJitY G;XJp+>$``[G/tGdId[A4z]= 7 F"qT<Ĕrщ>ӽsWFs%TKzd7;X!5$F !'?-Dbt1><6Nvr%1H2N]yT?|B,*.KVڡ^[QĆgPy&ebjDQy~}$/ʂo;cWBb DdH +v<H*$Q)GeD"*>^&2j9] k=\} I"40ޤPK yґJ\#285wh4g>' jj/2:9W R)2$ ZN)33*^Ba;cґHW#BI.{f|]ΰg,!ar5t6} D'_L(ӟ.jOP^IT"C&sf݊h:#-dB$3 B=d ךS~#SYusj:0kqgY;!1s>6Վ(E 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4u^"+Yk3j?gtW3g8Ehh3X[\ԬK,9Z-]$D"JӠyZ٫ȱ[vg٢=28G4YM*FYb\&/˳܃ݜ{e̸|`u: rZr,;NntQa6UiCGd2gU{i)6 ךNXpQyl^imL3121ko t3VߔjV}E|KUYo)Ed̜ JMgVrŪG81*|r>;݉!rO|2~Էa"^E͛.T){qvrex|htjDQ N'1`N3Թ+L -#5v{wLA }՟;V`[dDq/Kz~S/~yҜbQF1hYԢ7KA`}ɓԵpwD2wS rWQnI( @lxY*mFRjO۷ONkO)#f{Iy&CÎl$ru AKI6SV9r|ԓHЀ82 y_{7X=M'AӠLBQFRbID/zKHXIqf3m=5Dի `p  1&7N3prroyWel!93,i幙I(N2S#qv?-]W+F NL*3bBP},3t7N;JQ)ALD# CcMoWqX:KŤ|1#a{K竊,1<(Q*zT,} BS=k*[SE^0+{[s8 d&իd&#H6-}bҩm=ExP`rw< WKDp'CC{_Y0{ywIIDATeVwiX_rfcDد1B'zM-8bbr ^| ^MNrl".C0秮Eg2<ރ:M-\̬~bTx7ʤr oO?b3͂>-{$6<A(llC9/vO m{Ip[6U /,+ 7=;;݁䧮abj3=ik2J$+*%&<1j{_gf9gmjq}g܁fT y9|~y.__x109_,w炢{m]y6|?exf<~\?@|D6ykpLĨ<8]cJ-͗NTVEic{]+p[š(QDpǛ+\o'',NBpjHIʔh*JrѪ4m]@zrTjLDRM 4g}&aNնU`d^䥮Qo,8sI?i8cɉaiwW/.(,Zc0LyQ4b(||ގ#Hj[NRu7=1Jbt.]tBfE8{maA p`t=<8sEA7Ǧ B'Z,(=h#91? ."8NW[l?7AˢHtCO?ȴK*Z>-"qIRgw9ϸI~Z6=ŕakí~me[_gOSC{I !1.Zqt-:A40Sg'WKbpqq R'P ?@NFQL慿OG/I\\EgB%43uI)2E冃Vgĕl ®L/'.CrL|Ci^C@I zAOm)z0m=>6~ȳL,oT? _ʵqZTH >$D2vI(r|Bl8řqsD$)RҜLqvŒzL} ;ФroZ,J$JAk9B׵m_ J 9Ww.Yqd suě)Ύ/XO) iӿ#.ϩ8řdef݊'P(lj Kq'ُ#:*wO~Bt@_ݦ̖+x{u슻ς,IJ 7:"CRPkԵE(iPH])_4#6o_^ё0%FY-zG:PSCGfիD=˾|rT^}ͮ 'EF,}hu=-0.u{""$+ r)H]˅f&c `k?!'yrŨEZZR3W10yf!X]ϥr&u[~h1Ci6:DbTRFt:AшNeLOMʾ, 5h]a(*~08"kaJ|n^УkP f6"Qᚺ.̒ĩ}3&'+ܪ\1dRWLGzAGc<<Cߠ0}=* ~^;WJ@Dj8HR=x/T,6"7ne bjz,wtu` ѪEP^ǞO~{:< `h*zWgOj[OECS=7e5HD `h/ My1pn 6YMpH)H[}íWn.^vol`0V<uH%Rj ^knKۻOk[ ƌQ0.:ΕqHKBbF/pqvGo?Fc{ { CtStǷTgsr}ō [DI[A}z mW:m]g/*{ A෵0oW w7/\]E0tLԦ裣=x u [*cp:Qy.d?A.nVg=?܎ޠ ($HH]ޠӟOOzA,JrWvP75y(rn?J$ L*Ǩo=Ǖ4u^Ń5#;MLj }zPR㖛361.bTG]i=)NzQ+ BS ǗR"geN\a;r;2Ed/#D(c#2Pbdl>CTht hWvĨ<.? i<ʨqs%ߵ%冃&l:Mڍ^nkte,wشY37g~d8zޘqK)؈?5MPjֱWEטzοO1,b~%Vz:Pp0,xY6>ê=d$yh""gYOө $# GdfVQk.2_PFZc=dJl1zC‡ EUڌpV~:z[h@D"!%ږzķݔ"QRg Mw(؈LLlx1'c>T}C_':4sg^.\j8@Š7 2CYcf vo==8I\o?D/"Pj4&@k:Tp'z̙u+4E&z"ȸbfM1b369d5԰koI6rpvro |qrrifzǀC<}Hx/A.7ZMEQ@H( i@н-Wg7\WNap}A^3^V~z-8scx;{U8Kg[~&)*wߖ+8:幽^osn%+b^y !2" VE.?v jd}f}՟Xt1Ե4w]?>,y\,cC{9mxA?e%U8l7Gd+R5Fc;/"@Cy۬!ZuDX3K^yZ͘8pcQ=[_f`֓ƌz6|cCKN*R I%9&e!?$%&'3:Hl`9KZyhsWh(2"DkO zw5}fI R٭8dZƈvih?{X+RBKZy҉u/Ymse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC   UUUUUUAUUUUUUUU_ϗS| AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D" #Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???uu$??t=nNSU@?ݲ?ݲ?ݲ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2/PNG  IHDRc IDATxy|[9G-vر=@J!@i)[[( n)Ci@i0\n6tm BKI !$mٲ,Y9ɒWYl'ty.UIL"(݁I$$2$y&1&31IIdIL"cLgc<Zp9ܨ 9h<&'1NPl(*6Վns4U'|ڒRb:Q=L4")s$rGJ R'EBDcaEf\6?#gQ4 $͙1DMiکrՅIY^0 !,NJt#( AEE*g^v0qCGsQyB8‘^03{vcガO[RBLE01d@Pp$̘8]D9Iiwe9ńK hI 'H4L$LbpDca"0 ^9)<e3sޡސ% 듋34C8Uwq4s9 p]4Ҡx۞DzRHoO"IDUm1$ b:6UBaZl)f߁5bJi ! >A-^>]n&0 petGU4TՆ"ԄH!dljeFZ!B(*Pm>>V=]N2q4ep iϷv8!n$~7.+2GN]"T^񹉏(r)/5K !5u3` {ubtR#-zO36,U(/#?M$1I, # !oԹKL[cOزQy䗡XP>ۖ.fs0%@`!uՉGy[0!nbɼsӻ `* ðv\֮ 1p*FE_R,Uw5rڂrL`HiRG I}މG ^tZ8׭zV,\;eKM5RGJ-<ݽ2a6GSkJB~U?SYo:4wLX>Ȉ<ކh)9޼է|b= D@i|ԑDk1stJ5f eV>Zk8w\z⩧cjMeZw9}eca0 Hu'"+~[zE}:%E(yhbXNE759>}ёJɲjyΊTSzrӦM;da~ڜe^w?\oJ[)n2cٲeÞGdEI۲Z(JF~[ߚc\BHI5S=㬳=fk\}w;y>~xlTm4[f===]w2@V>Fcnsn:d菑H޺P(Ĭ%H)BSύ}U 5_w;N(H)r{_%Y?Z!lDnONϬZ̪SBmoAݟFݾ~iPҜ^ uxa /7%?χ,iСCw@QFkJ ,eVsmҝ{oק}\@KmJey'xG{-+a &-9^eYB 5я~ӆ e^y=n?Sׂ}(7Bgft;{x衇u]7%\͛zh8 c<QW7@J]{Oॗ ?luh'oO#,mw}qzj ؼy3_夔^;Z6 (S./E||)z< CO\s7X_uah1f- 9G<'ƑfծȺ_i:v>ȗ%o͛W-)//H`7-t5ݕh)[?9m Cy?v=.;O?0wB|90G[& HDȾ1(Y9vLLF7H p8ݩU[[9 AN[͛ s/Omr3Rij?=ܓXw\ > PSSC `ƌ߿]v B>O2B8!DL)@_VpsWp7pgrxcfϩW{b.+OwqYsY] P.@S,sn aݺub1^⤔Hlxꩧش),c <J9nfUJyts=,sEssAaIUEiϧp< |M 6pK 5R7NsD2eDqC׾&/QŁz(/_U)iK z~scĉB w,r˥ɥ'o~y饗9#_;Swyk#IQy=e}A~w!]wFu.]v?øsЏロ~2ƍ'or'.Qq?yHǀ\"gQ.Ob78sh~pT&}믧K/ :/r^}5j.b,XB$SQh>n3AܢoV/Wbpg F<SςPu.Jk]aygvZ.B֭[ǓO>qyW8q_oL%h\h\h{J *%3.y}~)PUj]mNi=Y;s|LHjloO[Bqi/3NeŢ ;>}Y a$#^O3c t]ε^v6ma00-[S!HE$d27aVKZ"v|tBHHEA4Jc޽߿7T(z5̮^ HBN-[x,iPT;㮻䮳q]$3'xV&$;}(-їb)>"c(h6 Wpp8D(ҋJܱc쳄AV,? |rtfTEXg}.}aBFک Qk.JAi_xW5g.zH)4be書5x pg^HvzQV\ڕ4"!xfV,8>p1n=4+nw#TUF5Ֆx(JR._ Hip=6I|N_ ]Vɑ]5즮awJjp3׆Omu+5 ap"?'? )%-uL9:DSS?/`Pzz;)/zHQď8LѦoދV.92iKRJő9x]EViH3lE݈%4@JvOUUsh<8Q1}f~Y4g@Eyz4 XWvqtv7nmDJcM{ ;8ϟ~fv{y[ޗzҰ\-F i|LOr \,ɒ#5L DA^D$dz4Z gR:pYq5L+LjѴ݁j-Z<`e>n}}vE ]ED!bz$'^Ķm8̑|Z7 Fb-{_H)u[H Xz9j:>#9[<\KGd F[~4㎴kي .k BAJCKy%iOoErWJ<7v?Mo#a>UaS\:_30‚ [زe /,^C_PY0xvQx/c;??ҾMv1 JA}Ҡ~8z ׮g)%72gZlNOIbiHz^ߟ`?X|9+WL=qc2{pг[Ms皟Kiw˧LԥvG3![ϻQ;uѨ>x|R#A=&GuA;bh#l87|3w_hzqqW*q_ 6n[olj4! rߞ R\_VqM ǚ Z|fN;rv)aZ~B`-DUUUZ_p+k SIՔyTU!^O_ _8Lz6ndVr t ( hn?BSa<{}hqS4wnN6Zڏ6*=џHwH>HB[qEeđ; zDC7:goc!>LQ_)?:nA x t&Yu9Iꩧs5˘Sl{NA{$@"_Ig/:Q@an ֮ t(̾ϣz|9?zchcU5-Gծd~ut=tvQX0z?zY3^7@ȋ?Ec|o{qd-}@ M ԝ Prd<$KciiJ^[̮Ohd`4Ҧnz=;؅׋nDq界{qd}2q3$R)2E&1:) "\gZ@}gz66C=H9vI9$01=@Mupuʵ9I*F Z"ih;dJDafK>C瘱SY=}hiP&DŲSgYڃHoԳ~ȸ@SW"(M|WRrxR`\qqB;nK*T5<f|Yӗo,2)3&@k.{sk gBp֪K8k%<ք'+\7Bce3Z>9) h!D}jU-=Ma3/„(ԝR>.gKO@.Z Rj1^^8P_ =] b:ƔZ3E]5t?+DE挡 >뉕oC Cv3v.+~ v&B< C,1?8č,ѥ$-$%(B!ŢNLӣ|(b74g4=ֈ( B 79 r!8}L-ZĖ®9x[)*t:tt1&j8.\v7Q\0EQy W(4Q0h/`7X! cTfa6ⱹ$$ۄ^deĂ6ֽN$" a9 *<ަ aǝW@k\ξ7(/ %G Gތ}֐b%y; 73kR3m/nC\vQ_Jyq5eEUxǟD].y̜v s}サQZ8 Idu#F4 ]:d,u:@bfyq4VfU/aVnܘ,hl`έ̘=?]:ij;>2ݭ:Mۦ )%vyiMSH0as>!& a=AkeO]X͜e̞yL)AY4zK>Ecܳe>OFbт%}6?\$$ v+q+@M*d)g=tef#ASGmэh`8EylvESS Pށtٗ$-soGUlh #_0#}/cݜ{о.|-DkOw#t+di<##x{,i~|\a1{ic4,j_3"62FTv ݆jh #FFhBtnO= 7H.+u)%7_EoYQcDa|{ IQC7ah<4 qlv ٰ݆iv_Hmcݼޛ̙;g=$ N8cDGO_UTE# ' 2,^F\8;F]:bya`^f#SOߍ88+,[ٕyDA:}͔Mh*]mC#1k֞z !Q_JIDATq #il;Ğï n&D@_~ާ<5zMfU/AJ$今 HN|W>WGRZ4e9 q: ۜhfpttk :iE`s0ceEU}+x^#VE*D ]y9hD|͉ `|u0v1AIaeᦦ3 gz{w^1%Etw5M0GSRg._ Ep9qݦY* sE pz9O@,JnHPZ;%XpՅ_"u]d7bu0EҫKμw6 p])xdN]2N3muܚEƴiv"ѰU9JæGLdk8*gM9ysVtQ\0y%aԁ$ ݈&qh_Ms ѵh~[*/! ёP$Ѽ9m; _Jj}60UU̡F*XB3%'&ɒ -r3T40 &h]aXĉ{{_*h,/+^8s NG>]N[2G?3Z X +b5H,Ϫ1E@̈%6`AN?meSihbWҾix(+BQX! g>찬ftξBw%=(C7bfiQ& V~/\e4#cuH)ijHdBߔ;LVU,\Ĕ% V~3Wt8;u4pz*Jjh<ƔZ̯]t1=H0٧@Sm9JEtbs-暧l&MM%QTPMˍ$\fN?I 裹(<&ս6wS\8`O]^;,C:4^/NG.کF4SBJ4BWyOa}BY> h׋/ࡨ3Wq5Kae܁63yynl6mh8NGwcHe(+" o6qNMY$oG)F61L6מEh5膩njaæ9˜˨kxO!>_q ih>HS{ݸ$Yu O9g9ᘮ-(BaƴSF.x"a:PPԬׯՐ9ڸUp9TLpi3wN_sN'?6Zr1i%gBh4]gN2TL7)D[HE'0tTUr$wVMSY^|Pƨ*`u̪>|N4b?g# $ Hh"M5T6M9>'UPK MU4cJ$;tZB2!qw0b.Ɩk{/@Eg| Ƞ \EQG4 "Ky찻qAmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC"   UW ϗ^| A*HTRUU **U!'jB/UW@3j T/P_U j_֠i_g/~HkV֠$D"D"D D"D"DH"$H W WWf#?Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???rogr$??W=@MU@?@y?@y?@y??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3,PNG  IHDRc IDATxwU?61) &E]H5oM%l&U1uwl ("T30Ss{vgAq<{{گHϼDF]eYXieF_6qSQQüsRZT7eu||Jn5v1~FVN_}K|\_!$V˶l3 u*!I2$$!I,+\P]*vrP.7l_ˮ=;p{\Dw:$Q~K=[pv/uryY{ߊsבG=waY&!Ba#ϟq1hR$r\.~? 0=p eԨ1i;\+|#+' =`6g4p<|y]}yKnNmȱ>ɰԩ-lmm̘N[8@** pﯾ2%/ëF2q9ljZ& rKBP_N[q%Mmx @2|iyX`w5|O>ۈij):Ý_$@8?Ͽ3$!l-$q砪.T0-#c¹]^dYAUdYAdYV̱Ô Σ76=fsJMqAEt>O !lܪ׺qX:FZz۶)x9 $j;de?~@B Ok!Ii)֞@$~ H]:~.|n 41\jaɘi׏ %4@U\~?ħmma"%Ym\~^4zlac&Q=nD ٹ^?BBȒ UT6Ʋ-T/7|ya)WEUڅF[K0zPߵRU6͈q0r~eyI$`;R !RDb $$"Pu;0LPO[@`&1Mgz2l ^WuP-t`BwT+U :kO]\]^í#S5fnl'L]qcj!|#$i&B(E"-@ʲۗR>>1$A;eO Ļ-$9OZ$ȲUb:=t%ց`]FCvUdRlEpw_pƎnDf[.>).ŲLt#BD?FK;^[ !!#I"6CiyB(Ҋ# Vw/2z?Q_`Z"i78 HZz3&nCS[-%UH\|CøT7˚.Ņx\>L@7"A[  pgs2f\p4S/}?LcsJhl=BP\X$Nid"m䖢AoEȰj,´ " ?FFV>ٷ1m^8oSu.M(FSk-Gxε񉔲p3|7!`x4-LS[mF:Q5q֤ c>6[w1` :i鱍>1!GD{~vX͸꩸\Vp.TMn7P 7=eThx"Bl+eO)3y_|d-D@=p 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"""J$I$I%vbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC   UUUUUUPUUUUUUUUWUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ϗY| AZZ?J(U*BJZ)BU_P_/R֠AU֤5[WZ֠P_!ZZH$H$D"@$D"D"D"DO WWWf#HUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???yy$?? 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"""J$I$I%vbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC+   UUUUUUUUUUAUUUUUUUU_!'ϗb| AZZ?֤UBB PK*JWUP Z!j U_jCZJUT!P!P_֯@3j ZZ5ZkP_"D"D"DH"D"DH"$H$H W WWfW#??0ꪪFvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???arja$?? \T@)P@?`vø?`vø?`vø??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5PNG  IHDRcIDATx{|Tչk\@KAPZ_UA9bO_*^Z~JxkG!H @ I?{.$3 ˇOfv^{ou}G>e DJ>;_]`J#'qrw,ǫ!DZH[|DD47|?u9Z#bJ!4hBCM“4{pݱܪ꧔%E"0 Rxt/mZ\u9dRhBö;BM؟Δ&1h90 X2PNѽxp,4%$00~ ӏ00 ?4ٰӄ;Vi5W5MƵ))d5]uֲao6M\UWs~ ,XԵI87)X^~]HMCJ ihRS4klv{WS||oΙl컮 W<SwAY4V]Gj lcJLc}ogp=nvlqbzl3y!MZXRDMt0#yffy(}{̙͞/A`Ex&A awK)]wxt]LKMbjv c}՗jo Cl65guA.aaņEQ?^0KcmcBrHXB8G+P!,3xxw%{κQ8|TUkOylk^J8 Uk<缇ilw'_Xs kgϞx^nB.V\Y3H8pV B0Dc .XK%(;PI'|k׮]<3W`уVAzF{X`CP"wRM> 7rرcYk={d„ +U8(!e'* _Ff8-,ʆ C 2N߿ 6c.B{OanA\,ijqe|BD׮]='''nݺ%~2]ޟ];7%{vs: '}FϞ?W_}5Dpȸk ftY Ups\I`-6pn"*j6nȼy.pgKU73R[_Fmjgk,Xmu]KÇ၃GêUg cg+O`Q ӂjDKJZ-ZDbZ)rhđJ3,ѣUCP{ޤ=#)gyΝ;G۶mCZ Y$$)%#F`?ywbvΔ_3gkTAEaJ /Hf޽{yf}]}Oܹ޲"ee5MD3si Y|ZdyM_$aL~{1rLA?ד̄ sN_v "Hk^*윩aO54E P?0ϝh/4ZM~?p"<@ii)0)EEETVV+70<Ґo6q 8YZ̕9&,bfk)|I^{Mg˖\y4mu8nׄUFY<ٰSB9qÆ2jHi8Wڎ_nL>ddd8#Dt$/>gTWYIL*i #GlghJ^bM>vY }(틬3M[$h … ?s J(4j8*؀i~d4EE c[NNwqG̜9{w)S\~"P8R1>v_[#\J9{~y<;%ԄC]֕ ۖt%K0q͛a`gǏӲeKYx1Æ cΜ9udzŋ/F5qzGKLi"a4Jv2ͻCl۶tN> =2-fe*o4{[\"F>sݾ= .dɒ@"}Q~e=sݛS޷PL)u˃ he"u,\8ء}L/n-3m|Yfsϱn: 8|0??د'C2`_ŋSYY#<rqƱtilְ|oNs^pxf :_="9QZ|0S/ѳsQXX̙3Ca 'uo u u!dܹ,]m۶?s=ǡC>}:ݻw祗^1{/1M#1QǙN@4MFFX>}{}i8ѫW/>ʁ"c999SO=Œ%KXhg֬Y!ѻwoΜ9gMcY g6&9[DEI)N-,'̹;ߖxУGEua`5l^HJIQQ1 .9qwb 233Y`Aj&MϜ=kK(ψ?[~Rvk@Zw҅v8ˍaY*]}#VSLυAR[l]lXj?H w|{uaK+"С3* M6s=[ͨ1M4VN ;SI#y_wο%~WxY5Uc8СC:CvƏoitV E79&LT\<˅ Mݸo"#--s33TV̠'`BZ~FYl.|E[&x.V5h?=SaժШa'O̙3͝;A9Ĕ&i &8T :BFwҊ+i 4 #FUvRg͖=7LlǸ7֭;2m-Zb-v V%F-~ًУvL XСx" N:ϡCǺ ҍj.\s:u;ӛ6mbܸq5u1o<^{5KNN3fkzNTnZ!Ra# ⏶u#p3MY:kQ^^oR\\Z=|M/_Ί+u8n&|YmY5U8uZrh1>W\kmyMd!@Eyqt1UU~nR3gh"~O<r֭[6h?#d[j܎l+!rntg P#|ؒ&á$h8Rr8e=֕ʪrF5%Vmٷ/vJJJu)S '? lIjRWv男寮q~GA=\ӹ"#i:1jN(|Z,f_}Wa%u;=L򗿬49yGu^?*;]m\0(;~C8i].nZofUKe?L5XW9-Ϗu7}Je*Ϋ5N,ԝaDBO5OQS]]8ȰaQia*@e6.h.RJ/!s)-I)~bU#n8ֺuȯǣfMh`kh}Cw"9.{TMj%e X<W-aBDN8/G&>q ،Bl02IJcw?VUq72qH}eZ2??sb_ߺ5vpA)9[?fD gXvdGwF]_}*$z&++EQ<{6oO~Y\7|uÁgɪ,uWn)}*y~:K:],VXaÜž~3g2f̘׭F-/I $'/:Od!MoX6͈$x֭ ׬QWޣSN^[QQIs 0_N<ӟɯcǎ*^:c@t NU+QeI;;v\u~Ę7!t@c΃hBmҲȆֺh29Tp(// à0V|ѶS%OvubKZĬ+^I};̟o奉YDϰTG^@ᤒĤf&$flݺҨ×'7Kr:H"*9QEu3̵|ܘ p ӹCzO)˓Nѭ .l}-=oJS(hSW$ nƇG<7e,!\$u[!Bw,e4uERH鵇ߤp.:Rfq\l"ML8"M[&w69%"2aIOvq`*OG8q{gTQ%+ha*Fʌ\{>Be6J.*(+z@ϫ9!<]ǥ^f~>iL f][>*aT*\MRŷoS2LmDd,qRe+Ёmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC   UWU_ aUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUϗZ| AZZ?֤UBBjZAjj ֪!ZJTUT¥R֯Mj?A֠CZ"$H$H$D$H$D"D"D W#aUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUFvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???f f$??RA'G[P@?0?0?0??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6 PNG  IHDRc IDATxyTgA""N\QA}Mwr\hfq3A3j3I.FLH(l 4{wg?Ωnn޾:]gysyW" b0DeHCZOؽXL/-͛rhT<1uegW,x{omwqG˜UdxfGmm?Eӌ e΂1z? jki`9ASSۏ濰٤𷭳kQ(p˾4 RVF TިQx' TZq]Sm>-PyÆ +PIg{(p3?mҙy<狀)9_EV٧^o奜AyſOˁG}EQx7Yx4tbBaȒaꘖQR֐Ɂ@}=P]]]p[<}1@U4=ah$(K.KF!83Xp!? R9spp$9VOsHKC'lڴ  90u\j0j"Ɩ# @k4}NCu<駟x7H#hjEȳp`䍭[2f̘G) ٰb́;rNwDh9nm , `޼̟77Λkm;"mۆw}9_3FqlƲ-,p9x:|6l`5d3{シ:c6mc&m7zY]ijQ/YM6۶qgcϟ?{w뮻0N"8pA: !?r@sǒ) W:q{n-XЮ]/xH}AW@$AV9{Βc^۲y+hH}W8OųtR~[>|H-zF 5 eezBR .çE Ѝ[5oer)f[rs9YfqWg^۷o; ^gb+9BÑe?`;x@1@YW _$!nhhaϡ-y-WUe˖-+\|;?`go>Dc"[Əs* z@?'$?I8FCK |2?|"DžV^̓>̡C2ܿZu$R%lOyh>5,8EK[؎`gS膆nh4rk1 ?ry7@w}k(ܾ=uē$dI=&TRȊ)3hA(+1}gW膎ahe .r m7}@{@u˲e2>gZhzQsInЊR.GQ]o]cgOO_"q=N:v,^^{ /JJܾQFDx;Oh1QʹCc3( 62ĺ^qll¶]+/DēajFh-<(5Fرcy/ $f` LII)`&waj؞Ҫ +.;_exܹKtNON8r `8~jMI_48 21 a$aOF8-b$"KJe^y_\0 h5{n9s;逸bJo0,\M0u4==YRYQ' %S.%KdIQ-=hض#JDyx$͑d z:enUq>]7mڔͪU44 ]2 lӠ>^K>wKih(r,:ZwJ$ѓFx;e_Nlڴ|;\UV%RIs2BmēDM'Z}psN6噟cX 8EI@` zUeI7T0=%gsYIt#IS{%rڋ'++EdW,^ݶHi1dxd*k-w=FD|P9j%P/*q_?ࣶ>Am]u R$ RwW Uˏ,@}X_UO璳nuppA=>bg9ylbI7kC(XS|cM~UWAgn5=x%yq² N*c_u-S5L-(+( 45"P+Iēqt 4P?'-@75 S(eil=n pp@D3> &R.D=/\!jpoّs)-ARbѤ8edzg^mX%% QD7{iC@,t2cL= Ȳʈ iXbᲟ~.3fO0(ޚL;܊]  !xq ".ʜkٖ QZ 8l߻T*iڵky';{`&eb$j[ؖEencVēHƈ&ӕe4LjDQA`dD6U{B9\^qnzt"J*#;w".w(2n=oVCKH 2(#H=fm{t3nk׮ .8sGӝ: Sװ-+xM6 ,CCUDIr?`mL-g橋y eplL8)w*Kˤ"Dq=!;uQS'cFLA򚟒(goڲCJʽN;ұtӳM/;[~ށzgyn-3| b[u$ɛ>Ƕ-l@RDYE2۽ebhIXk̶ βsTt;}$}Xzs_Vlb[MNx{~eM~&=#q]wtUE䓽ی$(Ls]$YERTD)v?d0S bGahNfK\6oegD#9i mRc:;_"g_La0rc,s={O<( 5̼>wڗ?N21 XcB4i2u?LV8s;3!]Ns^P˯> rgkz?!R 0f'2wSdI\t|]QUih}ퟘ|%`ZMw{˝=|f1 I#U]1;</3[3\w%$]\:Μp1wz'Hհ0̎ӁUُaF&wJgt3b eΖS9z?t?ڰ}`q+Gzgk=jlo12|/ ccYK.&"2]xagÜwIJ DAQU?}gyo O;, ^kj圻pp8itL/lӋhԶů^mx۱-\/4 #:P]u^9&[wbʲ1U 3Hb my_֝;<# $IT.ypJm[iv翧dPׯ_^w8xb8n3i%DKKSfo Y\ ~c;}}ؙD-Ȓ$)Ȣqp+ma9&iaXmّm=.{ժUL>WއˋGA`S7ƢDcY+_]}b R믿/5\㕼Tpɨ~P$V,dӎ˄uXfMDOuHt i,e>x'5}m&iRKf r /X*7<ħQd]ot0[on:z衬w2H'.)d >2Q7OJK&pn5{XAh!)"J$QAu,^LWz b1>89㩬η]{Ig[Xjҹ7 %|Hb"qS6BMa-[l:\&s>y"mv;WrcOEyyUӟv!:<\TG*m:0œ|~{'<6;a2PYR3̈VH0ovQ{YʉY7(YV$2 #áC]S0|y-.v<[%S|F8Z_ӦR8AuDRdm?_#oǡ,X$)Xi rC)V%6ؠb0j"_?DƯ}IA T4O4NTlvWf6WQ!RAR<>XF ~_)A_))"_ί,]ObX~[.#obDd͌ 7y 3L HF=K.F {Y6PpE.WK|jYRi|qwAw@ԍ4) C%Rz ]OtxKl;-3iU74)1Lt{A$ƶdIՕ'[%U *CUDAvGELy*bZnP~q^۱pC؋dFTL lE2ʲ>K j$Il,$\Zٖq2Am(1Mw&ϧoM!r.,)Xn^\Oqױ6+"13%?QՍ3uM2ۧM9IV%L|]l;̜z. +y( ĐxzpI%f卶im)c<8xzȌeizoLgǾ9Slē#38qS$̑PI[Qv,f?ۤ1$IwڶNjmNAOvȒ"+8Ms&!@YT-DZmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC    U_UUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUϗW| AZZ?֤UBBjZAjj ֪!Z¤*jP_֯@3j UW|*U!ZZH$H$D"@$D"D"D"DO Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUFvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???vv$??i7@K@`5R@?`X?`X?X??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 71PNG  IHDRc IDATxwx[y{K8$jږ-Gގ3ԎISN4ms;Imnx[l%R$6p$D ʒ*=y|;;x}nb7>Ks[Yʳ}s݄Dg\>MKUyF a*B5~eGd.^fI*J=^Z-Vm{/ E`0-ח<ŘI(., 7 @\ٵ曼sgwR<-ҧKו^zqc,ig5ŏ!krA+|߽ϔre,u"l{ Q4PYKAprrfo=wyA-]'3]keQ~R-gey :ytAm,xRFw~k5FEEJs+4"gßZJ=i5*KFy}eQϑ YwEmʬm9Asʻ<֏ D?,*KByT| Jt4YTHIyevW#ξn?N(rIZOUtY[=p.MY"3ebjaփ~(  WǎU/,-*Kb'1*KEdQ[XYYatz s ~XN2ehJFLJRˤl]0K5\͞dhU]ۏޠC $F/QU%hwKU^w眮DQ[ 1*D~3bk?a3/w^v_c_@B"ֶDX f Ąe$u`35p/Q~J`3o|XG Lua,@FJrW!I1z'Q& ME*H\xn^sE Y>EZE78{mUyeyxxzF^afBj7"Cw ,lj+""A&uI愿o8cI]i6[7d_^A (r=vʼiVdoFQiH]n!oeN 6o~^/X4A7\I5Gi9zc~ܼcJitY G;XJp+>$``[G/tGdId[A4z]= 7 F"qT<Ĕrщ>ӽsWFs%TKzd7;X!5$F !'?-Dbt1><6Nvr%1H2N]yT?|B,*.KVڡ^[QĆgPy&ebjDQy~}$/ʂo;cWBb DdH +v<H*$Q)GeD"*>^&2j9] k=\} I"40ޤPK yґJ\#285wh4g>' jj/2:9W R)2$ ZN)33*^Ba;cґHW#BI.{f|]ΰg,!ar5t6} D'_L(ӟ.jOP^IT"C&sf݊h:#-dB$3 B=d ךS~#SYusj:0kqgY;!1s>6Վ(E YTjZΘ|Ь!I9o#6&kmFrL!S1zZsRVSQֿ>|}kH%cJ9F(&9x1ẹթY_ZsJl1 mg$-#7e5n>8":۟3՟'MW_n$qjg ]vcR9 35|ݧ䧬 8ɜ [FVJ3ҜwD~LX] &E[7:4M 1#?Z|韈>"X^|j_$n_]mN^e|:o='Ƌ;lVwj.V C0&H82c\az.Ljm)8W۞XÜAYjxPk)$R-Wx|+Lȇq߱2o']82 T'ޡ0c 쎳el3G,Z6}_uJ@7("*Op+Jf_.z uCoS7pRLMqq6XULth2x)<}jJ5 J@a0ήxпP ;.08aLkt*2An, sg) //idZpFb*mP'yd㟳7t5 &c|zhujI ڴgwy?7BP C->{| ^ŝvɴR=iQ=Ј^oi, hYI䦬&"8) ѡihjzjʋ26!mHͥQZbZ8 jjj]k^"+p07VX Sq"xȫ-Q!) 6FNJEYmuTFn*=HfR+M'/W<ܼYUtuWd=`Va8slmM9E]U/W}c=_[*.&o,}FX'[~(YTaVosٳfĕŧv|#"8IܽCequz,>ӊgF7݅^`z+8n!6<ۏpǯ`R1b~ez5mj}_mޢ-]i+PJdH*Oe#C`o'3sQvNI])*w#"M-&&a|Bps0Yye_a[ԷE&u\pN]\7[Pn}ǿWfc֛!/xA*sWB@4+{hQfe_!,(1 ^ 6TO :(lWO 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i<ʨqs%ߵ%冃&l:Mڍ^nkte,wشY37g~d8zޘqK)؈?5MPjֱWEטzοO1,b~%Vz:Pp0,xY6>ê=d$yh""gYOө $# GdfVQk.2_PFZc=dJl1zC‡ EUڌpV~:z[h@D"!%ږzķݔ"QRg Mw(؈LLlx1'c>T}C_':4sg^.\j8@Š7 2CYcf vo==8I\o?D/"Pj4&@k:Tp'z̙u+4E&z"ȸbfM1b369d5԰koI6rpvro |qrrifzǀC<}Hx/A.7ZMEQ@H( i@н-Wg7\WNap}A^3^V~z-8scx;{U8Kg[~&)*wߖ+8:幽^osn%+b^y !2" VE.?v jd}f}՟Xt1Ե4w]?>,y\,cC{9mxA?e%U8l7Gd+R5Fc;/"@Cy۬!ZuDX3K^yZ͘8pcQ=[_f`֓ƌz6|cCKN*R I%9&e!?$%&'3:Hl`9KZyhsWh(2"DkO zw5}fI R٭8dZƈvih?{X+RBKZy҉u/Ymse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC   UUUUUUAUUUUUUUU_ϗS| AZZ?֤UBBjZAjj ֪!ZZ5P Z֯֩ j֚D"DH"$H"$H$H$D" #Fvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???qi$??7@D+?P@?֨?֨?֨??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8APNG  IHDRc IDATxw|ǟq#;!^ao VhmZ;mZj]hZ ow}.]rAm}8||?wx[tZ)8@|L2q1I8y ~x7jCRWblqX-19w~9N:2gyᮤ1̛Q.ICi*ij-Z瀙IIju͌(WyfW7KObaƒ_Nc  kes{%>Տ4MӐ% q1dd7eE9_a!+ي 蚆躆躆)c/,ƍs80}Zw)HEW sz4Mװ[:2By;55LY( H,KS*}ut]G%dɂk9-| X|4^;]˟ :?ՇSCjgnƢ 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e+ɊE{Wj>%ek6_,ߡCbgCBWS)^~Ͻ#LIXlt42 )Jd$jװYc/r u3cnQ`FMç"iي,xƹ]w}7Z n}?p AQ}Ȳ ] C>?<"v;`̌*}WZL[ WUUNFC> +@@ nTMTdL dlCsچ~ŋ,Y̰!}&G~,ְe+ 7`n _U" "(3J{Z1 QՔfyؘs+^ J+E8߹~TM%; 6ȍ_c{_ I2 {|.<>F (`u Dr#AD,حOs{jp{kڵ&|f4(+jjT+⨪ҳ;p*[4/WW*cWTaL΃x] 躑$LR>7~•h>Smj/|`=w:~u\*k]'5%xy\k`M= $YZ/rW5Ŗ/k=0>0v\GOmgǡ=x|$&D*D8gH|nkpQ#8}0淹7|/ޱG}W_} Gӯո8VH5m(Eeg]l 1xc0EUS̢k(#*yf3ճEQ2mLY+Y;ςC͈\].V,d>4]osO?_Nzz:cǎeTWWsm=#FK.?D>w!.ɸ)wvzOV^tѶh{A=3fH<.wu@n7L4Ր&e*:˪Wj>,7`lǾ};vlHݣGҿF'%U#[H0b[W{8}Nw%W \1EQ j|a 47nF$ ɓ뮻߮(_(:8vK2DGUt1,NXC8iwxZmƃ>]w⵽*ۿ"_Gn$!6utt/H ~w7nd0vVo%ƥNCn)`nڴ)"$7-jqAc$q -:^K hNع^o<.y.u )H -^F iSWMSYcDKg̛HKiJl 4 ge I2NgpAӵcZ]kZښa$?}N;+ȒIYEh;yn\GTP7sI 7b[.J\~o2ڕ<M AkGm_ڲo-+d%Q֫Ξ_Gg =>Ʃ%3oNGgہ7M+HD\lqqӛuߒ!ڍmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC"   ꪪUUUUUUUWUUUU_U_UUUUUUTUUUUUUUU?'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTϗ`| AZZ?֤UBBjZAjj JRT*PU R!RZ5T*'/~HkV֠$D"D"D D"D"DH"$H W W#I??3UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUFvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse 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"""J$I$I%vbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 217ac2 )1,vbinding site for residue peg a 218ac3XZ1,vbinding site for residue peg b 220ac9Z1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RESvv1,cys->cso s-hydroxycysteine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,met->mse selenomethionine MOD_RES1,vbinding site for residue peg a 216ac11-ubinding site for residue mg b 216ac51-ubinding site for residue mg b 217ac6K1-vbinding site for residue peg b 219ac8H1-~binding site for residue peg b 221bc1 E 1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RESvv1-cys->cso s-hydroxycysteine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-met->mse selenomethionine MOD_RES1-vbinding site for residue peg a 217ac2 )1Xvbinding site for residue peg a 218ac3XZ1Xvbinding site for residue peg b 220ac9Z1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RESvv1Xcys->cso s-hydroxycysteine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xmet->mse selenomethionine MOD_RES1Xvbinding site for residue peg a 216ac11Yubinding site for residue mg b 216ac51Yubinding site for residue mg b 217ac6K1Yvbinding site for residue peg b 219ac8H1Y~binding site for residue peg b 221bc1 E 1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RESvv1Ycys->cso s-hydroxycysteine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Ymet->mse selenomethionine MOD_RES1Y1AUG[ ?=￿?߿{?=}??Ͻ~?=??ߟ?}￿}}{???>Ͼ{=??{}?ߟ?{???~}?{?~ǽ{{?}￿{ |p fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ$MUB"""5Q$I$DDF$I$UUDI$I5B""#PB$I$I5UT"""#UUI$DDDjI$I5UUB#UUUUUUB#TI$I$I$jDDF5UTI$I$jDDDF$I5UDI$jFFI$UUUI$I$AjI$I$P 3LAC    UUUUU_UUUUUUPUUUUUUUUW`UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUϗY| AZZ?֤UBBjZAjj ֪!ZZ¥ I R5P Z֯֩ j֚D"DH"$H"$H$H$D" Wf#`UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUFvbinding site for residue peg a 217ac2 )1vbinding site for residue peg a 218ac3XZ1vbinding site for residue peg b 220ac9Z1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 216ac11ubinding site for residue mg b 216ac51ubinding site for residue mg b 217ac6K1vbinding site for residue peg b 219ac8H1~binding site for residue peg b 221bc1 E 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESvv1cys->cso s-hydroxycysteine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???0K;MJ@pyrrolidone-carboxylate peptidase; chain: a, b; synonym: 5-oxoprolyl-peptidase, pyroglutamyl-peptidase i, pgp-i, pyrase; ec: 3.4.19.3; engineered: yes3LAC3lac P 43 2 2BBC =???ab??????@S33333?@aGz ,AAHHHHMMHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW, aa9     f ffffffffffff ff ffffff ffffff f fffffffffffffffffffffffff ffffff ffffffff ffffffffffBfffXcsocsobb1;     f fffffffffff ff ffffff ffffff f fffffffffffffffffffffffff ffffff ffffffff fffffffffff͹ιϹXcsocsoaapegXpegdi(hydroxyethyl)etheraapeg2name=s] Xpegdi(hydroxyethyl)etheraapeg3lcart ..Xpegdi(hydroxyethyl)etheraapeg4Xpegdi(hydroxyethyl)etherbbmg'| bbmg2'|bbpegXpegdi(hydroxyethyl)etherbbpeg2c Da Xpegdi(hydroxyethyl)etherbbpeg3   Xpegdi(hydroxyethyl)etherbbpeg4Xpegdi(hydroxyethyl)etherbbpeg5Xpegdi(hydroxyethyl)etherawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160 _mse  Elys      Ethr  Eval  Eleu !#' "! $#%&$$( Eleu!(')+/(*)(,+-.,,0 Ethr)0/136021045337 Egly1768:798;  Ephe 8;:<>E;=<;?>@A?B?C@DADBCF  _asp<FEGIMFHGFJIKLJJN  _proGNSMOQTNPONRQSMRU  _phe OUTVX_UWVUYXZ[Y\Y]Z^[^\]`  _glyV`_ac`bad _glyadcegdfeh _glu ehgikphjihlkmlnommq _ser iqprtvqsrqutw _ilerwvxz~wyxw{|z}z{ _asnx~ Hpro Hala  Htrp  Hglu  Hval Hala  Hlys  Gser  Gleu _his  _glu  _lys  Ethr  Eile! _gly" _glu # Etyr            $ Elys % Eile! "& Eile"!#%)"$#"&'%(%&*' Eser #*)+-/*,+*.-0( Elys +0/1380210435465769) Egln 198:<A9;:9=<>=?@>>B* Eval:BACEHBDCBFGEEI+ _proCINHJLOIKJIMLNHMP, _thrJPOQSVPRQPTUSSW- _valQWVXZ]WYXW[\ZZ^. _phe X^]_ah^`_^bacdbebfcgdgefi/ _his _ihjlrikjimlnompmqnqops0 Hlys jsrtv{sutswvxwyxzy|1 Hser t|{}|~}|2 Hile}3 Hser 4 Hval5 Hleu6 Hlys 7 Hglu 8 Htyr 9 Hile: Hglu ; Hglu < Hleu= _ala > _pro? _glu @ Ephe A EileB Eile        C Ecys D EileE Egly !F Egln ! "$)!#"!%$&%'(&&*G _ala "*)+-.*,+*/H _gly+/.02/103I _gly032463547J _arg 4768:A7987;:<;=<>=?@>>BK _pro8BGACEHBDCBFEGAFIL _aspCIHJLPIKJIMLNOMMQM EileJQPRTXQSRQUVTWTUYN EthrRYXZ\_Y[ZY]^\\`O EileZ`_acg`ba`decfcdhP Eglu ahgikphjihlkmlnommqQ _arg iqprt{qsrqutvuwvxwyzxx|R Evalr|{}|~}|S Eala }T EileU _asnV _ileW BaspX _aspY _ala Z _arg([ _ile\ _ala ] _asp^ _asn_ _glu ` _glya _asnb _gln c _pro  d _val          e _asp f Bval g _pro %!#& "! $#%$'h _val!'&(*-')('+,**.i _val(.-/14.0/.23115j _glu /5468=576598:9;<::>k _glu 6>=?AF>@?>BACBDECCGl _gly?GFHJGIHKm _proHKPJLNQKMLKONPJORn _ala LRQSUVRTSRWo Eala SWVXZ[WYXW\p Etyr X\[]_g\^]\`_ab`c`daebecdfehq Etrp ]hgikuhjihlkmnlolpqmpnornsptqtrsvr _ser ivuwy{vxwvzy|s _thrw|{}|~}|t _leu}u _prov Hmsew Hlys x Hala y Hilez Hval{ Hlys | Hlys } Hleu~ Hgln  Hglu  _glu  _gly _ile _pro Eala  Eser    Eval           Eser   _gln   _thr !#& "! $%##' _ala !'&(*+')(', _gly(,+-/,.-0 _thr-0/136021045337 _phe 1768:A7987;:<=;>;?<@=@>?B Hval8BACEHBDCBFGEEI HcsoCIHJLIKJNOIMLKP HasnLPOQSWPRQPTSUVTTX Hhis QXWY[aXZYX\[]^\_\`]`^_b HleuYbaceibdcbfeghffj Hphe cjikmtjlkjnmopnqnrospsqru Htyr kutvxuwvuyxz{y|y}z~{~|}~ Hglyv Hleu Hmse Hhis  Hglu  Hleu Gglu  Glys  Ghis  _asp _thr _lys  _mse Elys  Egly Egly Ephe  Eile          Ehis   Eile! " _pro"'!#%("$#"&%'!&) _phe #)(*,3)+*)-,./-0-1.2/2014 _leu*4357;4654879:88< Hpro5<A;=?B<>=<@?A;@C Hglu =CBDFKCEDCGFHGIJHHL Hgln DLKMOTLNMLPOQPRSQQU Hala MUTVXYUWVUZ Gser VZY[]_Z\[Z^]` Gasn[`_acg`ba`dcefddh _tyr ahgikshjihlkmnlolpmqnqoprqt _proitysuwztvutxwysx{ _glyu{z|~{}| _gln |~ _pro _ser  _mse _ser  _leu _ser  Hthr Hile Harg( Hlys  Hgly Hile Hglu  Hleu Hala  Hval Hglu          Hval  Hthr _thr" !# _thr#"$&)#%$#'(&&* _val$*)+-0*,+*./--1 _glu +1024132154657866: _mse:9;=A:<;:>=?>@?B Elys ;BACEJBDCBFEGFHGIHK EthrCKJLNQKMLKOPNNR EvalLRQSUXRTSRVWUUY EleuSYXZ\`Y[ZY]\^_]]a EleuZa`bdhacbaedfgeei Ethrbihjloikjimnllp Eglyjpoqsprqt  Ephe qtsuw~tvutxwyzx{x|y}z}{|  _aspu~  _pro  _phe   _gly _gly _glu  _ser  _ile _asn Hpro Hala  Htrp  Hglu  Hval Hala  Hlys  Hser  Gleu _his             _glu  _lys ! " Ethr"!#%("$#"&'%%)  Eile#)(*,0)+*)-.,/,-1! _gly*10241325" _glu 25468=576598:9;<::># Etyr 6>=?AI>@?>BACDBEBFCGDGEFHGJ$ Elys ?JIKMRJLKJNMONPOQPS% EileKSRTVZSUTSWXVYVW[& EileT[Z\^b[]\[_`^a^_c' Eser \cbdfhcedcgfi( Elys dihjlqikjimlnmonpor) Egln jrqsuzrtsrvuwvxyww{* Evals{z|~{}|{~~+ _pro|, _thr- _val. _phe / _his 0 Hlys 1 Hser 2 Hile3 Hser 4 Hval5 Hleu6 Hlys 7 Hglu 8 Htyr 9 Hile: Hglu ; Hglu          < Hleu= _ala > _pro" #! "!$? _glu $#%',$&%$(')(*+))-@ Ephe %-,.07-/.-102314152636458A Eile.879;?8:98<=;>;<@B Eile9@?ACG@BA@DECFCDHC Ecys AHGIKMHJIHLKND EileINMOQUNPONRSQTQRVE EglyOVUWYVXWZF Egln WZY[]bZ\[Z^]_^`a__cG _ala [cbdfgcedchH _glydhgikhjilI _glyilkmolnmpJ _arg mpoqszprqptsutvuwvxyww{K _proq{z|~{}|{~zL _asp|M EileN EthrO EileP Eglu Q _arg R EvalS Eala T EileU _asnV _ileW BaspX _aspY _ala Z _arg(  [ _ile               \ _ala    ] _asp               ^ _asn                 _ _glu      ! &    " ! # " $ % # # '` _gly  ' & ( * ' ) ( +a _asn ( + * , . 2 + - , + / . 0 1 / / 3b _gln  , 3 2 4 6 ; 3 5 4 3 7 6 8 7 9 : 8 8 <c _pro 4 < A ; = ? B < > = < @ ? A ; @ Cd _val = C B D F I C E D C G H F F Je _asp D J I K M Q J L K J N M O P N N Rf Bval K R Q S U X R T S R V W U U Yg _pro S Y ^ X Z \ _ Y [ Z Y ] \ ^ X ] `h _val Z ` _ a c f ` b a ` d e c c gi _val a g f h j m g i h g k l j j nj _glu  h n m o q v n p o n r q s r t u s s wk _glu  o w v x z  w y x w { z | { } ~ | | l _gly x   m _pro  n _ala  o Eala  p Etyr   q Etrp  r _ser  s _thr  t _leu  u _pro  v Hmse  w Hlys   x Hala  y Hile  z Hval  { Hlys   | Hlys    } Hleu               ~ Hgln            Hglu                    _glu       $      ! " # ! ! % _gly  % $ & ( % ' & ) _ile & ) ( * , 0 ) + * ) - . , / , - 1 _pro * 1 6 0 2 4 7 1 3 2 1 5 4 6 0 5 8 Eala 2 8 7 9 ; < 8 : 9 8 = Eser 9 = < > @ B = ? > = A @ C Eval > C B D F I C E D C G H F F J Eser D J I K M O J L K J N M P _gln  K P O Q S X P R Q P T S U T V W U U Y _thr Q Y X Z \ _ Y [ Z Y ] ^ \ \ ` _ala Z ` _ a c d ` b a ` e _gly a e d f h e g f i _thr f i h j l o i k j i m n l l p _phe  j p o q s z p r q p t s u v t w t x u y v y w x { Hval q { z | ~ { } | {  ~ ~  Hcso |   Hasn   Hhis    Hleu   Hphe    Htyr    Hgly   Hleu   Hmse   Hhis    Hglu    Hleu   Gglu    Glys    Ghis          _asp            _thr            _lys                     _mse     $     ! " ! # " % Elys   % $ & ( - % ' & % ) ( * ) + * , + . 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 a a a a a a a a 1 1 1 1 1 1 1 1 1 a a a a a a a a a a 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 a a a a a a a a a a a b b b b b b 3 3 3 3 3 3 3 3 3 3 3 3 a a a a 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 5 5 5 a a a a a a a 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 c c c c c c c c 8 8 8 8 8 8 8 8 8 8 c c c c c c c c c c 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 c c c c c c c c c c c d d d d d d 10 10 10 10 10 10 10 10 10 10 10 10 c c c c 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 12 12 12 c c c c c c c 13 13 13 13 13 13 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 140K;@pyrrolidone-carboxylate peptidase; chain: a, b; synonym: 5-oxoprolyl-peptidase, pyroglutamyl-peptidase i, pgp-i, pyrase; ec: 3.4.19.3; engineered: yes3LACB13lac P 43 2 2BBC =???ab??????@S33333?@aGz 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