Ct3.6-1h9/data/swissprot/ 3P2L.pdbdupa 1TYF.pdbI[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Atp-Dependent Clp Protease Subunit P From Francisella Tularensis[/h3] [p]Y.Kim, M.Zhou, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3P2L" target="blank"]3P2L[/a] [small](deposited on 02-OCT-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [p][!--icmscript name="42" display slide=slideshow.slides index="Ligand binding site 37" --] [a name="42" href="#_"]Ligand binding site 37[/a] [/p] [p][!--icmscript name="43" display slide=slideshow.slides index="Ligand binding site 38" --] [a name="43" href="#_"]Ligand binding site 38[/a] [/p] [p][!--icmscript name="44" display slide=slideshow.slides index="Ligand binding site 39" --] [a name="44" href="#_"]Ligand binding site 39[/a] [/p] [p][!--icmscript name="45" display slide=slideshow.slides index="Ligand binding site 40" --] [a name="45" href="#_"]Ligand binding site 40[/a] [/p] [p][!--icmscript name="46" display slide=slideshow.slides index="Ligand binding site 41" --] [a name="46" href="#_"]Ligand binding site 41[/a] [/p] [p][!--icmscript name="47" display slide=slideshow.slides index="Ligand binding site 42" --] [a name="47" href="#_"]Ligand binding site 42[/a] [/p] [p][!--icmscript name="48" display slide=slideshow.slides index="Ligand binding site 43" --] [a name="48" href="#_"]Ligand binding site 43[/a] [/p] [p][!--icmscript name="49" display slide=slideshow.slides index="Ligand binding site 44" --] [a name="49" href="#_"]Ligand binding site 44[/a] [/p] [p][!--icmscript name="50" display slide=slideshow.slides index="Ligand binding site 45" --] [a name="50" href="#_"]Ligand binding site 45[/a] [/p] [p][!--icmscript name="51" display slide=slideshow.slides index="Ligand binding site 46" --] [a name="51" href="#_"]Ligand binding site 46[/a] [/p] [p][!--icmscript name="52" display slide=slideshow.slides index="Ligand binding site 47" --] [a name="52" href="#_"]Ligand binding site 47[/a] [/p] [p][!--icmscript name="53" display slide=slideshow.slides index="Ligand binding site 48" --] [a name="53" href="#_"]Ligand binding site 48[/a] [/p] [p][!--icmscript name="54" display slide=slideshow.slides index="Ligand binding site 49" --] [a name="54" href="#_"]Ligand binding site 49[/a] [/p] [p][!--icmscript name="55" display slide=slideshow.slides index="Ligand binding site 50" --] [a name="55" href="#_"]Ligand binding site 50[/a] [/p] [p][!--icmscript name="56" display slide=slideshow.slides index="Ligand binding site 51" --] [a name="56" href="#_"]Ligand binding site 51[/a] [/p] [p][!--icmscript name="57" display slide=slideshow.slides index="Ligand binding site 52" --] [a name="57" href="#_"]Ligand binding site 52[/a] [/p] [p][!--icmscript name="58" display slide=slideshow.slides index="Ligand binding site 53" --] [a name="58" href="#_"]Ligand binding site 53[/a] [/p] [p][!--icmscript name="59" display slide=slideshow.slides index="Ligand binding site 54" --] [a name="59" href="#_"]Ligand binding site 54[/a] [/p] [p][!--icmscript name="60" display slide=slideshow.slides index="Ligand binding site 55" --] [a name="60" href="#_"]Ligand binding site 55[/a] [/p] [p][!--icmscript name="61" display slide=slideshow.slides index="Ligand binding site 56" --] [a name="61" href="#_"]Ligand binding site 56[/a] [/p] [p][!--icmscript name="62" display slide=slideshow.slides index="Ligand binding site 57" --] [a name="62" href="#_"]Ligand binding site 57[/a] [/p] [p][!--icmscript name="63" display slide=slideshow.slides index="Ligand binding site 58" --] [a name="63" href="#_"]Ligand binding site 58[/a] [/p] [p][!--icmscript name="64" display slide=slideshow.slides index="Ligand binding site 59" --] [a name="64" href="#_"]Ligand binding site 59[/a] [/p] [p][!--icmscript name="65" display slide=slideshow.slides index="Ligand binding site 60" --] [a name="65" href="#_"]Ligand binding site 60[/a] [/p] [p][!--icmscript name="66" display slide=slideshow.slides index="Ligand binding site 61" --] [a name="66" href="#_"]Ligand binding site 61[/a] [/p] [p][!--icmscript name="67" display slide=slideshow.slides index="Ligand binding site 62" --] [a name="67" href="#_"]Ligand binding site 62[/a] [/p] [p][!--icmscript name="68" display slide=slideshow.slides index="Ligand binding site 63" --] [a name="68" href="#_"]Ligand binding site 63[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1TYF.pdb3P2L a_3P2LB1  1TYF3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' 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[T(eˊ46Bʸ/Hߑi^{%P[G:(1F!o8;ˏ~y{{iFd-Gzn~iqB=Λ~oVKhޢ5o9hJ>3d|6Źke'a'[d7S(s@+ R =݋ݑBdeK6}\F{(G-tO* ami`%FuD]BNԟyHL;d4(\~2HT\j fO0OI}u iE>+\ٶ rZlG'Qʊ_z}{[ ʢ47wo) FFER ՠf)/r;^{ᅯqG]]ravgPxs@w p*?m9ȮW>ӇݸY}o2tXI/DŭV0蛕M@ ,d ޷;˭ҰsV}g_o$ eqȅW͸\!hZ4Z87we]`n6Lgqpp5\H=hS+WXr ժ[+hIMr\}^6NB!]Pةwf.Ϳ't&P-͝Q˝plٟ<6bdcʅʵgs  !zWLlΔeChZ#uY9׼xolԂ"P9ss,ù5 '//M%X3N2JE7Ee/,(6zmG~;w%Jmڥqҥqʊq !}B-zpڮ7h`1m$u#=UX)2iݒ%%>uĠ3MG Bf{EZKq ʳM=Ζ;][| 1&^ z?X^\^W;NisX$<ț2R')7Άэdd΂ ۲=&\t/w16H2"B:T*A<^^gJ||}>\4iSܸۜ[lVIGB%#/r2By7&M~ҙ=>W ehH n2])(΍$mJk>IU ""'$HTUI$!_IQT%UROUU$I*W$I*Iubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???33$??5?ਨ?ਨ?ਨ??@@@x@x@ ???333333?333333???#~j????333333? 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j֯jUZ_Zjj֫Z֫ZUZkU_֪jZZZV֪֪j]jZ֪kUkV_ֵ_ZjZZ֫ZUZWU֪jZW_jֵk֪ZjjjU_ZjUZZU_VUZ֪kUkV_ֵ_Zj֫Z֫UkUZZ~WUUZW_jֵkVZWZZV֫Z֫_jUUZWU֯kZֿkUUjZj֫ZUU_ZZVW֫ZZֵj֫Z֪֭j֫Z֫UZ֯UUUUUUUUUUUUUUUQUUUUUUUUUUUUUQUUUUUUUUUUEUUUUUUUUUUTUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUZ֪kUkV_ֵ__֪֫ZU_UU֫_֪֪U֫U_VU_VW֫ZZֵUZZխWZZ_֪֪UUUWWj֫WW_WkUUkUkWj֫UZ֯UZZVW֫ZZֵU_ZUV_Z[Z֯U֫ZUWWj֫WW_j֪խW֪ZUV_UWZ֫jZZ~֫Zj_U֯kUVZZojWUWծ֫jZZխWWUVZVVkU֫ZUV_ZV֪⪪*V k | jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃3P2LB)g)| jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"D5 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*Iubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? f^ $??`.(@^5?T?T?L??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residuesUKPNG  IHDRc IDATxwx\ՇJmj{oe˽w 6g:fZ0 K -pŸJ[}?VH.̣;g=̙3@??݀׋ ?9θn„݄+ 3+?7 uL|+<)?^{L|r_$=>lrO?lƝ+#ހ_]3&CuHH͛w= Yg*NȘxƎ07?", y}Zdg)̹)H+>b1u3;_ &L]bZ-.čFD^iT5|xg EcyU y{Lxv{OvbooB[c$۶=78hQ*#;mo ~v =7vT] ֭]fI½qW5e7˯Kg~rT|#4TFV!!<呇J䚐0bo~d+NSg~RA.c;2#msp8.;vk@̤T|>kXV=3|)(x:WTZVz _"̟SS}./gi.kZ1es拉Y( tcň E^ޣ"#IM:]`*'9g~!m0/:4PF\\6 O,ȗ0 qQ[!;:{^U ǿDmTBn_8hFwue̚u'?@DZ[LO/XNql| 2Y':] @cw\tb- EG_ 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C(8xL(( 󳅾;edT +7Z !w/oz{R\WvTeD/ \$ IDATǎ ѣ_>lf2Yb=[ L?QPn>}ÝʍXlZbqV5Rtu9x ʠTVB(G]]ƌ)Ų9x%ˁZ܃QQd- UGZ1:;ӳz}4ՕAxpf.׉] rHU(l> hlLd0w (N.%ś1fL5 ӥf"11 F|~>c7RX>nc;6^4dj>D<P jttv㋊*`2Eb)qM$FבXC(!VLho/'2`F\v O?] R [46E]ݯYVBs$uLJQ7܄4oī@=yw իz/ ?Ck!a5L9aJwB``%7ba9/FO L˂>>@A3؛al6ܹbMHKGY&<բ=f1N@d鈍5)G܇z ~'q;ZWjk||l+-a@.0m_`edy7n9._՟u4SS_\_̌_}'w4^U !!}?_!-?P}us`(>%Ũw/=0t8ba\n[Q*k `0ިBTK *M'L'||S/&N|ÎO"R@z)%e> [ezy%t> } aXC"NH"#4n\!Sv|tLq;7#"p$̙ хPg댻 mm0g2b=X߯0w/^8~4~Ml~/׮աL0 RR*QZ de"b_!@_he? AM `6@`@[̑o X@˗?OjDR'YC(?=o7R*s).$ r:Rѫf…+#+$I,>@*^uh^%lNm 9\GDwZ:a6p_N< f7 ) ډӧGc>"S[x|jhxD] 0jxyܹ8dn~GX,+`Fͬ5dvv܁P_ RCأ:&ӧ\w`xOJBéC)i9z}𐔴Fc t0kqj bc=w6B @}`WD ,`iôjK!Q'ƌ•+Vx2BJHӊ˗_իp=Bu[̵cGivi)){)&i^@QVBC3 {Rm.Fr7sކw87]Vk"̚epqc˱8q,Z-! ju"7!9y#._f5T,^o\#& x`ROK b2GzEh7-]Jg+EGϥ;l",lI?s>~ڴ&jH$C%Cʓ3}ݽL6BCk($Ұ#<6]3foe} o ?B'Ρev<ك>P\\soCÖ :Z}.MzsF_scQlzpBT^gaZ--zL ==b屾]WjLv vUӛ_ʰѯn*jۉ8^/ر[b'"e'6-1k<͇Gg۴Lf zղ  ,MO7CU(MR|& yP}iRr% ~);5+Ҕ) jU\F89y ?#YSg::F ?+ IOdeFI(cҤA23$:o&v'!Wvu{ 5{{s.J pk'Қ5C@ZȦ٭j EFF{JhCU%_T\X.E|^Vз:l֫K`痎糦iOc# a4C}=^c~;C^OR9h܇<{0ΏڌVĮ:l}]g'&"6, m~Bw-C]]x<>/ĠyВV7 3:c .yuȎ p_$B qr{p>vF6U/7wIU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃3P2LL)g)| *| jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"D    DB E5e=@= =%Fw( mgTйJN'hso1>b5W-czNgel 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jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃3P2Let)g)$* $I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$ $I$I$I$I$I$I$I$I$I$I$I$H$I$I$I$I$I$I$I$I$I$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT2. @>'            || TF# Bqag$@$$3?*Z|\bZbj\4L0tڟ42.7X){WQKlrh|j" DZLZ2߱F4Lx" ޒ$_Q_/6ۚc ,)9y/!RC 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AWhUvY<8&?5jߓm 1vM.ͨ{H]P DoeϧSҥQYu~ #I! @W Ξ ҹL'\ď:@IWÝ_1%T v,B{|:}O<{$Aw LC%T"R!*:#A%Fc##L14G&τ伞CљCz2[ ~;!c]8 Q7>iz͝DrFT*S.NbҖ-'o yG-g꟞VƁ{z hp$^QE~mN@纘[pY=\}<dqpyX ՝[E{Q lk dCgd k`$Qd3Ůs0+z4x}ù h5u \bB~ x%(})%t{+*Kp *ۇ>z#^237FI"aj}gk!?\ICrʆMfyyW^ o)I"VE?Oԡ:"V8Te_z~}1o&JR^֜sծuN['(߉fu'Qr-&KLy 渓NيڊB;pTQ y%(_AKW_RZl!UMѨ.,0^fHU `9E ,u GĩP-8?^DzGH82]}I7kРq[*&JTSkp|"CK 2aH/l@5k}cP/TwjrT܏NƑ3eGPǫ_mQ+GiMr8¹J>s  /j4^`\w9IY sK}+I r|n2x9*P4tm<Of]Pâ\`sf&3s-OYׂJ })0n##~\yNp`%|JipTvbi+\ ME~4!fOmɿ#kLzSzDdSX3Pxd)~=dMi5Ire: _^Iq&yy| 4EK76nNcm{-vyX#s*'-9zx |x_8p{&!IC`5lԕ[AD8zv֜F9F= k]3q[^` 4h҄c&Q-&VF$6t䜉\Y3 ^HĄtC8aMw c6HMO5%3!*V`=U3X `5L}Eyj/@S}=" ._A ad^0ӗ-x܉2ВWjnœoj`וeWe%M>G5D42wf*|{}%EDyjw?3"76YvT,ZZ m* ]y'ׇL^1ǎe@8Z竌#O-o"@hÁ}@œtDw^~4 V]Sd'(DSΪ݀?Y c-.uϝt'¼WyGQz{N;d-/ECe#@^uI"<^C c7e/"C,x@r21$,x e/Ojӄ'#;dQcd'#IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYF'            || TF# Bqag$@$$3?*Z|\bZbj\4L0tڟ42.7X){WQKlrh|j" DZLZ2߱F4Lx" ޒ$_Q_/6ۚc ,)9y/!RC f׋S%Ys•nXJB)m2Æm7j#+]xLJ㋬r_5 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Q] f.-\GDB2l~21U!7 a}GgVݨkd$h0Sjz;MTBGVH8$p;)} 3kTG5((]ެhIDIV-y\rqAH(6BWiX& iҐTTᒉK5^g=z Z"EA= SPLL(CEG3d[RbiRQt)wV LB9(씴̼j5RQr} T;"7!fvQ(#@R9v9`YvSұ۝xy;,#i C0iQ#lbe%ŮYo|TJ<,uִ|=:b|j1kkUPnsyi7RM^j #kSBUw6TEےUSTSUIGUDfdjcAm@lE"`[l%F@1i:ti @\,'U(N (|?ULk]O:LqBbaXk 袬խrOH0w(&zU ޣRC:mѰR@I9r3ٽa "`yI*@ h9H<x'If1[46ci >@Q `R1Ux"8,:@ b"PFZl!`aQFnscaxx^\550T|5JʌI зdP:KUzUU70O<<4_>s֧oSLpĴD<ؼzď+#w5hkjzy*ujjN>C$HQ>"EŨqq1q(𔼼z:.atj!x@#84p.I @wGg=q9R;$$ {rST=N7fB')h ,c<}j}= YqlNSHМ ʪw1g9-SL=$POӾ8   3*!H:L}!l|(-!4' >fL\2esO%QS$UTzkޭj{OsJiNscv;vukp3 @@ET"A->„iS}SW{UmhĊi&B`-ϝ3NR&8~抻=ST Nlu$I< ALA3@ڹkhk$PT )"A7Gbn ` ^ڥώ * ,@@!U"@gTI1=4ODU}wӪuG7:H:iTi!@^^,P矵TvqKSmH':jY%Yy4ꝥ_F}jH"76@gޜ=vyפi/:lv_LpTŁdJŢ# $ @b tp@:F PTRNȪz'} g@*PfU8hVÐ@5PO#ƣDF66*F$ņyyhjJA8@ /A ?E4GΝF}3? Ņq(z.#LL<%*4Ozުk2(}ӰFzhNQU$>̔T# @1Tz5CM5#OICUǼܾoLuѪQ/N54ĸq RZjjjjh,yq7 bw|мZh{Xj(ّku>ͺU3DP<4Ht"##ĦeC1C1#3Rb4####bbs$EXSH3MPI"dFţFym RRN&`kȷWkۚ}7vE%qĠ0Mzij8+ (!`cŹq_R6(P#UL"v4aUՀH !YX!åTÂBdFHra:sI#^w4֧CC+u(e~CalDEQoq0q1 ?T}Z#CJUUCT IB;"O" ! $葢5}Q$A$F#k2IDSjM929oC]2sAp B> 4ÓSPP OYH=/DwfX\\:,1-N 3$Ij$ $b$ #)TTY$ ?~$ڞTQ5*pl}~)P'y @ ΤewWsECμOCOj4OUPAM/w?W'|BA(V3 >B40B L D AH2u^a  ћ>傡bVU* ޝ$~'' 4&_V#H jksH9I qA(,S1¡ JKYq1D@m4UYKj> T#>4!P3# $x)-3J;D4$731,-U-* i@lq@ΓN `|(gS T<;nfbb2bQqqz< Gʌ*SqhzK;Tf=-xnjJ NS# ,ŭurY6Ln1 ߦIE7{0Uq*ZL`xRU*\R8W%k_ ]-Ж n˸zikJqM\&P" %RyCRrifyZ\m*.K 0kC,0\n!]*Rw1j{V5dK%4=z VNLj"Cu J&L!H#256>l|ȔF81E#ϩmJVrU]DL(4cK%g"V )Iܹpr*4=3u¹ۑk㑍Fh"eZ? TBz5]J:1毰NRGP'mi9J<7 % \m)(YS؜|)hL8" XG|H.:S8 A0Splgz^^\bYuYe]e]e]eYuYuYu]e]e]e]e]e] uB(P뮺:뮲.ˬˬ.,ˬˬˬ:뮲.ˡYu]e]eYuYuYu]e]e]eС]t".ˬˬ...ˬˬˬ.Yu]e]eYuYe]eYuYuYuYuYuB]uЊˬ..ˬˬˬˬ.Yu]e]eYuYe]eYt(u]e]e]eYuYt(u]{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{v   44mmmmmmmmmmmmmmmmmmmmmmm@4H, ֓IʮQ%Ȏ""9$WZOYHE ZH "8AtP]5HA]OyTf(L]x(m%e+$h%ej,ySiisPD@,XpĘ*$1ڒk"0Ah$Y$@iXy&T]gʅEBE%t\L[mΜMh6T攦*IVUUEI`#gւi&JNmۣ3$@faN%fɧHʚp@ `DŽ (& $fA%|J ]&n,LXpX(@PA4di0a*Z AD{ak=%&yTY*ĄlN]9MV`D1rfn8 a`jIfڂ̬q16  LjbGL0d`f0=6Mly!Px `0ޚl*l $@Hbl5YJj$&MT*%."b(RAubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+1TYFAfffL?p}0+3P2LAfff333?p}+?$??jDB@*@@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1BPNG  IHDRc IDATxwսE]{6ZL70Bn. {~s$CBI(!:1-c0`޶7I6VLݕf-W#E,c$0e|&nwʟ` 6,$c8)y m7+]έBp_\4Tzm [X¦~VNJ%) U^݊G# m'&}{si݅$(k$Lh4PQ260}%sNg($Ȓؒ@U5TKC<ضIToAB=σ۶v/-$IF2m>bff?y G4H17i$mL4N<ĥmϻضɆm`Y&ك$Ȳ")w6?ǚcuȒ$\|4>>ߓs<4̓h4PUDdwc y4Ջ$!0?Sszdym{eg0-%sNW-l7oGA";2sblYF$Iy\x i`>d*9Μx>OHQmyL>܈G6G,>zΛq+1t(E5hƋmBēg:!@AK^c$ YQxSbG/a&{>?>@aLT$w2jJW$/=40~|1=%#BwsSP_ui 6gqs@%{ǣc#h6)ZvDzZhmmB$gM#ēQ,Y& 5 EUX~'m{ٲ-UOy] Eֆst lay<aaZpo*D<%I$iewPU/AUU_NXr%Pܛ_DQTYq~*eKaԶX"L@6_:{c #I"A"AQA%*&TfyC0$?YzT/z͊'#]FӼP(ı3S9)ݼq5XXE}.*J'ikLKw,NTTdX2ei阖a4F{i]t8PhOG(NVvv.. ;m)t#IpuP~ E2û$^Q#\FB!dYƴL,Ӣ*3Ofl LˠyH69|r J4%NpD7f Ja:j0F22eU͵|qM|qMkhy]r}[2/ߙ(DXhM(#g4y$ TǓzW miaibZ2.\VLuaq;ffW4k" @ߏ3Ũa0 @f 혮k5\G[;Ȝs?f)+ҲĦ9BºvU# .1ECE\۟(qL!$.;騊nZ4%ByI5kNggFj2fn惵lY"`vXm{eC=vF<Dz-ae]}5n|*dY&aQdY!>q⤧#87*,3-׍ q3meZ}#tn=]XۨAe4MB~^$hh6k{,*I#۰6%<$If3X <84\Ͻwэ܅fIQ5֛i wt#AK8K/gtL+E]NּcXsYlRfakY&e G453 ң8q >pY C:C4MdI ${n$<{>@ExIq#~㝕W닏]0fczV]{ʑWRY6gw q 26a꘦U6m#H&ꊴlǾ3S-,t@ dYx4=ȝwmy1 Gxw"(Dn_Y!gl#¼Ex3$$Ђp=gJvm2z<-20 ^lEz=hVrBygPmlܺS?wO.@r5]S>Y) Ǘn-hvrfd I.k[*fcʧG[zfNXo+p #7-cjhxki Co~{ny}GdP;ǚG MvzlRzy7dAr2gJ,ʫi]2ųW IX+vv9YQǚy;r^Ӎ^#Z}~Rhnsk"Jq_²m}?@I8N{p㴕oPU9(r  GP5jNJc {\2d++sr,1cY%e$%`k=UQvqt;O1w2 w"| ,L%˥'{Nv&zhp1`I`.Q4vz !/tgQY2p>m"? 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(RVN%й2䕠^|ES=(֭x|uE %-ƝlZ,^z~!IRM7DGGUUNbw_ gY'# }gΝy睙Ve4?F<>$I"GBFpRY⾧~2sE;lH¼$YA5ELGH㶎"YmgKgB*44-Fp7fG?Z>贪w<$I:yv?]m۶qO\r o>f_w߀S_f9jC:a QTTĚ7^pm\%{Ä9/]2 j~ڢ`v$gӊ9]R<zWXAYYӟz=Nٜ|>?zL^ CvQ;[r%P(g9iɥx=ϼv'8#IӃX @*eޞg}/ESN|YXXHQQ"M44b ?=E;N$#Ѝeb Gg"W,x; '2eϬ+z)'q|=[ML'D';ǃʑW^b^P nppEsʑWi':-eYv걺G=@uz/.<1 P'+XA!=:4al|Y#OH([W+0tOnDB~[ڵkYz5gfQ㪫} +AxQojƎKyy9^z eP߲vp[aӎ'Ķ !_<4652█Б k%76[|`&j`0$ϙz #PH"I yh]'thkmŰ 0mH:K~ҹgf.ܷs[|LZ[]'x"¸qpp%O$I$8&Zµ9w}䤓N! "*T'51z.I=FQQ-U^w; zB{=cf, :u 'k1c =\*NKR{(ۃX”q ;zr"}O)I'-<ܝ*d\Lח'B#zKjaB, Ga&S.l#! b׏[c̙|4N>dZZZx`&JW cƸó$}~./ f5nr7gLXiFjdr 3OÅ'0,ύ M!(rsqElܸ1# l2VZ5ĩ8]lByTAӼhUp`>&GcN1T~(+CaA d-ߢ|2_>.8ikkq00M;`֬Y|4Óqu-\<>ضH=s,CS=x4/{5| y"d׉:DUlDc#Vd.R| Ȅzē,bYx ';^idCٝ6(~.~#||3.*4mp"67{צg5-IBQCW[.kC7=W3^c&OLʕu\ s%еceHaDG8r`+w9xΑ0St$)id-+^`m-<0g|'aw,296cOSK#Q:S3zG#jsmi(qA4;=[vMx;S_l۶:ZW\o Gؠ)iSփ>׿EW8LHs[=T;"=ڄ# ooQx=mưE&GZk'2zhFE]]]fWOr= /==v7g,FM1@#qKbɓN\8Vc۞wiS߼Ozsgowj_x'3c۞wyett=,[yw[s\?CQs?&S5[^f%$S1Jp7:EDd Y 8xꩧr*.0 JKKa ƒX`gc۞wٶ]⦌WMpvm K.BUUY{fM]&!X\+Nb%P~9"$Iԇ kCQ44Ke˲ ssW s߇|lyӏ4u@sJƸ! )t#X,8D8NlC,⨯#,v?Sow܏`u]zCiјL `S1Lh'؍eNgؖ3̛~(tw~OH݁;VafyYfG޺_vQWQ^RC]`p٨g,lZz̼P4H)t=nV|vQDm5C ?0x*JK۾WYTZ}l2״ZA?_-l#lܾJ#_e0hyvlذhrW¶a BE6o9] okT3OM5mc#$˧[ tFO( Uu6$''QH:?I(UȊ̄9 /P}G(eCGz0 Gİ Gayx^^|oi q^S9M%-L[<'h $&3kBF2xQVRI2`WHP"/XaxOkٱo=4q57?+~)][^(}Ԍ$5r20ӡ$əQ/m`$hEIa1ڇ+a[&+spoр0y< B=]8zmm;-wcFVЧlZ&]"eϪ(" 5pW˧Kײ E߅h^0"/E<[d0 Iښ$0c@zR'ځK7l ,7)QeZ?K b"( t6xJGwn|)~3udcT#\7()YQM[6h`fRr#`1Ot8`HE1-7a$'P!E&mLK2-<0b 楩uh2mnXN"L:Sh8Nj=(FRlZoinܒFc#Ҧ8ߙr;p4axE?T0X,Jm6&T 5+T2ID۰L2x^Bt(ͻ7{y"Ͼn,3<ʲ,18ѱ.TXL,X{9o>y{$u oQzODz@k)Tf9je;8 [wIG H^LUh\# Dq/z͵DCϷ q.«{Նu9`xϿѻg?#RK0//vr{#X3&g ,z@~eb)#A(cԛOʊjX2dDEX&"K I=Y%$Uœ)` h ?Ic=CqG~%mS^^/=FC.C*,gTA9W+ !cw<ͮÂ$ubRWܩ[y;.=F7TEFQnL'H^QBpK4IH¯k/Mb Q5,_zyb[N,~uՙ*<\T y#瞅;[픣.19Ix޸[',£{ :J[eIq,u}R;k=N~ZV0[A#̜!PQ~yk9é쪒>?>4a|6b&-rNOc+O9J<hSQk~#;;]& nq4Hwx\pF]G2}[C85 V=e[z)e*)v`C@$G8p = uuE"zst"%_Շ6*3#IY.uN٫{Ez y4 v!4!_Ug9}pB:}np$x?L͋=]wluNػz -;ʹ^qw3}#"#˝T}V: @Q59Zi$O?h^\oerB5og\ q9OrQYFnw>BptF,dOI/BFu=gP$O?PU$ %Oi6ocRM4qDG7]NypmDS\ލ1]rvfh6O ||??]ѣ2G|Imôl?4'qm̚KE$O?oގm٘FnC7^;~/9;XeZ<&FL`Δcl}/-{yΥaAQ.Dqq[*IJz_)>B~/$q/!M}NRzx2پwS~z˜8||[A_SrU}(+CeMpթ.D .=ȊS/܍"3ڌ)Ȓ$+nӳtA G]N7n лq (âyǒ}9kۿo\ r-:DbEZ/mdIᙗCl ryч|'/|W$ǀyӏg\ ʊ- 棶y;?{KO@!y>febTx2BGIU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???OG$??>@ K#@b?T?T?T??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2lFPNG  IHDRc IDATxw|չ3M],۲$7"n\qۀ!`PC &TJȥ%B Ӌ7m\WՖ9;J+YjgΞ99y87{8V EVE]S, ёJFZ/4MůH]כ0r!{_0g•&wӯ_w=:=3  !t*NDu{=N IBk53R{!83l. ix|nNk^xe!mD6j"#gptbm0}/<!Pu%UzLB52L Y+}/H,h넻7⡍It:w?t.TlgQlȲE 0 RY{=5Łjê9Vc[j/j'tc9 ̪B6gӼZcx7C K" u%tKiH˦]^(4" :CpPDmcyD3ZxN#8H2NKje&wyىF ΄!! s s#' 1W fE7%)#H~Ճ$ɔW!hpDm{F<BYMM7+ȸ9.j$I"ɑ}BSjs`22E#!71~/ŷc=jǭwF$zݱr [✂(>vLBbk @ϣ }=ՁX.IHMA_v=c=3M{>:eEvV~>1TߙgJŔDn]-͆nna٢ѯY7C(utc04M 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F,75S{uo;B5\?;opp4zhgd $eOrw6⠡u˙Yǿ@<,J S928j')x,w["|{4zUAHıҽa9eUE״7V;-ӥs2HNH7.=;ozƦ:f[0$QD蝝P{*7D>F2:ѻG>'u2b86vij.nKǶp08otKI fL邢X$46n!}2j4|^|y=;:u:0`H˦]ErbwF7w3s9|YDaX+槢moZ^02>*'S:R9#ymC,z9먪ÞH}Cۮ3rpkDTLeqr2ӿwy=k52f\r&{!ŊUMqA>X\LN-{W")!:S&W?g7y]D# KIYJ<ƍϚ!=%ĄtfEL}>ՋӈIcS-s혶4ܵ\8c9}Y黆t4Ofz6E;3 $#U pk^d+W 5HJHc̰٬me$9RIIݚj@aMqji DBMFҒW.fM@|x}0i Cx~xobk8\>DG* ޟ'٫ ظ;#AꚈ~\|OP" JaѩjvE;;/yS~c?LCf 3ʹxO6P^}Ԥ Ls)Cd5ӣ[tGE:ipגFU]|){(&\&}ܙ##h NOIZrwdxDdI!эmWb:ѭOTg HH"%+sM? ~ssd2cU~:hC;`q!:`XsNXMk ZgMƈtYdd$X-(V;3n6hkr|qu;TR,]~KA'] no >C'QXa%|E.k4y8rA۝Ae&#Æ[(>7;W'KxsM})؅Ż_w3NW̊Nt& uN9FnX9 <&ƍ8=&\n\n&4ՏnP[͗F,!̺W^d&B(K;vvXEm}HpY;ׅ%3rIq5RQQӄJ9Gve*tK:7?0J1].V!5:<=N}CiY&זIDAThM})nU Xj HB^<({G:Άzzg G9{; LPO!,LALӾa}=N4MLҮXlǪ w]$Ew Mzg E'w.s~`)<Ӵ0y􅼲"2c3},S #Sj'mnAtKdևc.5 Usp"̇9$t >Q#3^?4kgC\ߨ{m>붿G~^S /.{kX6dق n5 RђVbEci5T8IK2`ٙ Y1ifh:+чnх!rDQ[>W[dP5 ZdN/~w I4 >4RGCۋI/GV6%8"n!=#%ZC9@(Va5*/x|pq$'Mfzva6Ivi57*۵4ЩFPPGzC0 D HdFBn7^ɲql_Qx@zJVDvDk,aBơRUSPAϢ?~^7z&nwg<s[ PNAa'-!/1CV")!ܞd|jTNVװZĜۮ.6osq5j wxygS8b"e%Ntyf5~dڌ$$5* !xLEemhHJHwVO0H5ɡ4] l%n\{RRSxH}%#@So$59eX MA,(D5&4< ܞZahj3093016bY=żO[ٚAC3]"ǰJ sb`c\; >}`d!an 1wGTC =sCOO!v20000YAdu"9H/E 3ÝG>|~_6Vv3IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??8@7?@)m?@)m?@)m??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3 9PNG  IHDRc IDATxw|SHjY-[a `^B!^B()OC* B jb 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R=tFnd肪y?\WC4,w"U|ΝsFٿZ77AN i Vmn}D{s;Q-Dԑ:5)UEלB/MX;v4#*P {mOp-PGs]㮰R'×ϛEzZW 韤.}D \MOuBPa^蘭H-)g>yh"?y?PTa>z%I­zXWʫл`dYjՇX"Z 5L_ng_-;s2Lsi=X<]^Ҽy2IfC/ dY Jۈ$ҲE@B0O=->e55tӠ%t|g{®QFtN~N3q ײ|{\ /=4(Cneek瑙ޅ-J`1GQTم|F N38./nKzZ&o;EQ$F/)wU59X>C'w`'L+,+Dm S]́ |y!f8qHY04ofdjc>NIĈ~vcxG#;Ӯ?uشsyt4\.o||lzڴJ=#A0'?O<ڝ^k'{em@N!ph,+wa^|]wf|10+Uip%KlD5HCob"r4Kkw@^Nr Xو[>E#d҉#ɲ#S=-71A(,|q~BMbāu%9qE/̈́3ɣ( _H =_<ӯ7 D$MAV&x!1{֒a.{c0N!p+ nDzg*թMزk^\ rſo̡F|^y΢ᚭ|2ٶQ5:3UL`ILU;{Yd2Ȱ뵣ݭ[npoDvIENDB`move=1000;blend=1000;3P2LB1SV SV k | jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? ;3 $??;@( @?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4i5PNG  IHDRc IDATxy\U>Ktҝ$ 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'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? $??D@"?#?#?#??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 56PNG  IHDRc IDATxwx\ՙ?LSl˲-W10X0tfI`M&aIHP6!tLl)..7ٲd2ͨ}>{s{WC  ?.}CCFZ.$ g!DdYFd$3B4H Ci,@ _!g=&h! [(wfh>.H fCB'.qk! 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ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???QI$??TB@"?Q#@?@_ ?@_ ?@_ ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6$PNG  IHDRc IDATxye?OUu5Gfdr!! @ G8+!+./ꢫ⾮,ﮬ W$N&ܓ?\==Iꪧ~]yy~" R:H)1TJ a@]w]gU>Đ+") &4M8@ɓ]'A lDZlSD"le/֢p\ â,$U |M'Q_bVL(kX#)mxEEJ] x@O4b`H 6g9icfW/uټyRJo?ESus,0A2nA=B q qP5 c{Da<5Ʋ@ήVʧ8G>>H$@*ecGSӗHn^mpMv2[9jlVb44pm\wݟ mRoCO2',@ DD#qx(J"XAc.jk? 7各(ܘ 0%%t%:GI *s,d<ظq%˗Ogwb6͘r&UsY:\$ KXw"Lc`cЫ'Фjtǹjk'xmgzB 3 &M h:`騯11g]wy"{R,m y-d۶<9mU=/ri QU hA6#'*Tӌx9g6A*~n3u+- mҝaoSΘ HiNJIsa(jgޙk*9}T%p>]7.F(92ӏvJ#H!A ?()!ue |d_)Us 1p-'xWt=!m t ?B=a%N"akW# 1-q٦0tv{{$HmQ'hGuL/?xէ"TTjxj3Āz 8׷Q_-47wrodc OЕ0V@k1MΨA ~# K4YA S x*3Ϭ5c׮FoZߩ:$ ZIgɞ0(eS jkFhwb>29sTZQAc끓/Xm8Mm "ӷ5ޗ޺qj?ۨ7Bߞ ;]8cb9vn 7 K$޽H Hg7RҋW$hq?U BoB2k]9D(G 8X}A5K`Y笼"`}!3oL %Yb ޳ضX8QRRV/ppyQU]y ;[[I4I8{Ze;֐7qLD:.l=u)3kziރmA8XƸj+k޾e^R)!y3V W,WY9|XP?hj?ea=ʦuQ,7{mƑx ~U8&12^7EU, 0BQOa&?Ց_xu~"}(/B` L8T;|ug${úޙsyq dݚ`tg8Hi~~ۡ#(Bv$0$O4LW!ܞ]98 uU9lTM)g8vgqX)t7c%[laǎ#*s2z7lHhJJD#HaJ"E ή67´ ̝={_ 8ҀF"URRB$JdD.i6d2@`&VcYzWlGUvKQH4v:U母Tŗ xE;n8Jm׾62wiP;sAJEF8!P:N~2_j#P^Fʼ+w-^|EV^=6:Nd(EUQ:n,]O4\#U tiz8@\&Lo&> '{ev;_o'b=2Su|*HBq::[No.f J'Ktzdn6D" W80l@Ɉ^U9C^v,>-c:ٟd&?èwd=Ϻu#D[IQyC]K.$\#mǦ#ބŁQM zC+]DJQVRA00RؽFa:^} &%gD"w(BzJطwJ#(m[-`&QP1M[!Y2-RFxsrBИؗ4G^8|/ƶꪽ)' +p'ggʉKQ$etqgc>2Cc's]M$\wOw-Hu_@f` ^K馗a,;X}κubcbWHIh,@iMj[y~(,v#mn.3oJӆe[ttН*oŊ444Mo~JaZI 3A&e$H .6'H>gՔF'6leBP=g(e&X2\@Ja&ʹwSZ_}y̙}cfm~8d{rʳ웼7ViĺZyc`X4g5z 0-67;gS{,ӕq9kkX]mo뇡zb-g?=B ²R5 >TTT:8p~;o}[cby%s?t1n@Z4hi?}Dd墋uw@LqmWSWWlj'8z(|;_ֽ^{wMx?C:PffsDmw(ƍLL'E_8C e1ύhѰlaf;Ç)// M 7,H܄޹ޛ ;1L&#$"e2&ߣFx}Si'xX8eS8ڴӖOfFi4773H.~BL|:)9wşs->G@`#nh%-b`(g f !7<&.cMm @YY{/$܃Ӵlcđ]LYx5k.pGUAuLa6jakc#B *0]%eF3|Ovmd ']e1ƒ#yRJ4?KG8lRۖhF?j4UCS=;m{_/?:ճz)N7gy V$p%~/S]] ^;XL[PdR\T͕Ӫʙ6'e~9 w_?/\.]wEɇzh24KE]ey-@UT, R,7Tsdf9Լ*{/A}}={Ge5\3fy 툷nbzTQ3C>yÌ!V,ẃ#o::::xaK_iӸjl.\VZEmm-<_'(DžGrIgOL*FUAt-H@ "[7h"JKKB~3fnx0**",Y2S?O*Nhܵ:2 ,YsBڻw/HUU# _^{9~"wEPU UQi1՟DUU?g20OP%Izt6_.-;Xuϵ=|T'JM 54:{RjfDBM7Rw}vZ?OuV,X:䚂O*:܍ew3}є@i@ s:L̙SE"a_y>~\yE_M!9kY av&%gxRSW[oOnv./^-1!=as&*AU`pqz.]MSSGHg"\t/ TH@դ騪v*g9ܰ%K>ȱc[_vAT eZHv?G3Zt1gBSuTE5$)#QƃtMڳzLNO,gΦںܪIRM$0g<]<_he~˳=㸊_#4AK,]/n0-7a"#oǞqSÊLc`ًfm)zlǻдoo~}9M,;m9嵼)Y~5/ŗ( m`y1Ic}jՖ4f@8Ӟ_=ml9N_dJK&iT(/ K&(4Ü|S`),Ĵ~Ex\ɈBe "{⟕Y!Z`_<8{哟Lt{b (atEh31&ikv<,ˠpۗ?)\Ͷ5m8B.qJ%dKo{3뫪R7n$T6t*z HP///h(;_MQPEM,ۤ62 ()%ǚOGiO2a43LS"ȮzU'I+4Z q W @IDATE#/7騊"pJ#n?5)HI/{IK2x /)-@?J~n<қɕ3Ph<!TB OccنX#0Nq>L"TQEQ~#2l#d//ux39.B߆wolI45 O6(Ӏʙ;Zllu稅QЂhhn&ZE!e&}/gxٳ.GBV ?t7_t4U'=&E:Mc[}sN"Lѵ e50$ w萌#U Om^C|sQ"2$RqJ"cs4$.zǴ~hGjkY:|T&*v,x% P(V[J2'$*%ۜ!cB7IIXf Gڬ?#6iT3nxD]ǡ$\oFEQoLQEπy4XcɘTeB<mmGίYCFUc+c "IENDB`move=1000;blend=1000;3P2LB1SV SV k | jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYF$ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???º$??TC@Q @?C?C?C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7*PNG  IHDRc IDATxy\Uw%[w'$d#H⸀"ʀu:브GTq -$dO:t:o޺TUwUoN:s:U=TկsES Ly0fzUe00 Y5 pa}s63ĔΓwT"HIBdfXH60OPX" ?abǚw ^s=1c>OKFhZHbK_=T!2d)ܩ"H6܅dוdR33B\Ti躁ԑ8|#Mo=1Lҏ ՗F Hl&dGRz3GW `FdԴ5 ԯI>HSN:nꄣ=jwǁ?dU!l]It!0"{zt!-:OO=qICaJ /O LwiڻoX3ôV]f򞔤Iy<at Kp<9h0@; Sazs2{b!K LLol6K8}m`S'% $Y"kh$v[ڏHVt$ZwerQ3]xcy`̥U"I2xp; 8&'[䭟M;0$D7$]Qo~ {2+YdLCTi+ BBעt9n$mٴ0+=v`$[E%piϨjj;Ĵٮ1uv;k<l[$]ƤLw$.tl YvO  =}Tr;tyұ`}!uvhlyֻ wΌy9,!{LX}OMy=ðIM\.OS­Љ׳֝^ـx0$dΞȔm[~̬,+NBٛyv6E [@Hjښb$;ujں@QtFS{^ـ[`I"^z[1E  {@"XX,xT?IζꪫxwqV`zekc:4udHā <n^u/!U;2L74b~±z#tg Za x={ƖiUy3H qp@9d !}9rALTҗ4lU /|BD.A / B4^傞z裩r].K^h 4=nێR.IG) }촞<(>Wh8HIqz -Ka/x\ s.;v VX^ qI%pz5_"$(^o Ud5/ 6LsxMr7[>62RV^O>*!ˊ$y{?%Ip"=GyO4%8X/Z2>~|a3MMO/2 Bix;U(*dMjhn?ObkΝ?!5M]R,#"rW@IM2,@2>56<|_Opa?Icn1[,+Hs&=yN6l0tik_ٯ~˖-[ xm؈'ٖ:Y~A~_s2o<*++Qh4ʷ6Pa⶧`uVrd^"-pشi?F1+BUTY/qb6Ddiש#n{߾}#+F,Xn|##n{8ZR-=#sQe +7c **7.u+H ).iAsqwuu޽{f q-3Hjy6ns=XQCj]hppG%9UE̪^0t'E~}+k[5#[+%ӟ}ғkuM--R eʧΞS#$W|f/ÇG>uuUӹD4ޗ|l"[mwA֮ ڻxtwڊau3vhAyH Yr%֦wbg( RgÆ F,o'%#:N[ql֩)==۸eY!o l{dT$!&5y g*~Xy3Gll]A",^{Wxp0Ae6uuuTUUKۭ{5بKV>~(E{af3w6oa=DQQOiKȒesL]p#P_m6wj!۽Y~=կx{ޓt@[[~w!%Us ܿVil~7 %@d$Bi/ΟF2i03ŽṂ/`Þ=:Ʊp <c;;LS˘ J5'2c̓&D0PFU, !e/%~?b1ƍ?֯_}];#ؼJ4HSwe˖g~o𶷍,()) ׉<@YAELܕ9?Nw)*, ŜK߀c>+ēOys.\(n G}tq>U>ORX`\W$e"(@97$@Q_Saݤ'A xYv˗3r444`&n魷p׿γl%X,,HV !GNfT0H%~6T^}h5sVcn}N@4^yoOg;X(*,u'!8ܴ#ΤSDb=az\7ow^ >Ę p-k_,:5DA8MQ(msZ~jx`c=j?bG;]gK<6w~{<^oqgzshj( yLst'h732;5n8oZ[[1o{֟q?gn m8ȳ x `=re-vdr:vv5oUx!OA~{r=w}7O=JjQ^:+?lV~Tƕ+k^mCp|-x53㩒O< oN(=Elfq:.Y;mg| #mb/V$SDy&-r*}2:66#k.QHA}}^ǘ?89ݳϫ-VՉO}Zqbٲbk-ŝw9/{5q V⒅׈K^s<zE6vL&wܙu#~a~DI<79gXθv':K_#㏟kDbŢk~^J{³g[Ʃ lN/Yi<9NZ)=?_y- uw s:v%#D;}]lC]7o~ mΨ.ǘYИV1~O~ctBSJe둰ܙ |Ab~&sI ajW.7֍~+-SUV;FEVQdU[AEQش.?L s]`1~.)E@Ax~Kô~KBATdbJ I] :; J9$y5 G`|}i^:jλ d 7J&K 43wȲ?aM]in-pm§ȓ<l2+ĉIEdk~!aKFS~=gv}Nf:y}Cy'_ ţ>$׶JRjtQdY4TÍo ϋ(i'#]8)*,cZL=(ii.3^`&vؑ|{n i8bEq ``@!>$ GzQOyE9ͧOp1"8xoHN:a:;}q/G Gt`(%%!KO44.n'qq{F$89ug*^9w|έxT?.B @ aa4`3EìKa$9z ;3^<Ck8fQB|mVqz-/ttM4&`e9KXh IXOÔBrdYF$$+xѓ`d`^Ou_{ PVxeU+Y-/IGgm'Ȋe(@9μW9xs?`Q ,wXX"L,!8q#Vi53h+qZS0Meui"gK2 BrK# Gb9/{%" CѺx9!GIT$ IU}O_̜K-Q"XXJe,|B$d #IRO k"$K|㐝?Œu&xOXKu]אh^Շzs:z c!D7hXN';zw$/M4Gx"Buಋ7L(I=ALP?}GvTEeilӇcrKb:I]#QxYt:~o<($eN2!{ 7@?HYq ;(FA׏n=K=0u#9n 9Ԓy8>8x"lKkkP0AuX"n$)/N$C_%'##''wJ]} w8  -†;;!Nz+eWv}ʿq}=|DF?ĒyWM\H$K$֋\s ~Y^~Ȉ-MOl4&?M(dͲZϽf(ƫ޾y2#N|uF馳9sj)k8ODD}<{hh/û7~k?sjzr# @TRdтD g} WYy|Bz quvIҌs⷏_g^}$D2[/uOWAUY-@)E<{06> >YZJAwY0r$${"m6' KT΢_D?DBӨ$s IWͩK" m2I{ Of+|WDaA}Yws?.'%4 FįNsOLlq}城OPM5,Ya;X4g-Aâ0w}k̦/%K\qn U#I2.v?/Y,\&y*Jf*>0UUȒ_v[hm]F.l1kVeIvJNu?@/Hkg#iOO8(GX5J/8vS^6nc-ӟ^رÌ᭗f+?UYq~m-:P I2>E U-tt7c'O`5ذa!ze$qM___~C{*q"Y}IGI;!q߬hH& bdcӦ%|K&+5ׯϲ{t+i5y-74AP"`~e4X:ɓ @9^ ےަMK+=O>]>7EY]Ĵ٩P'^qx Bam 'Ik.}/ *4 vsZ|:Di=-/4M֯Ux$L3!Esp LLvῦrZI5Δfų,*ʦ0c+fPՊWDa)M\]3b?k.%=yU٬}ĸH ;̥ ǣz$kQ,>"1w`)e\&@0j>?˒xA*p[T@_ww^*pLdU(H$' KG WOɒlE 裪֝V1W,Ӕ$-@Y=?C Ģ9kҾTlz$ [wz`G7ː%b$vIAk40!+(qp_\d'ܞѬj~@$J N3"Kyao2{;b˭0B_@QTTá.>+2#9fXʱ7RAbάeRRHqzӹ)#GYT4T$v"fO_̴:4M^z,c<] >X-ttʲʟUee!d]5;19pT')IE$J2\U )k;PHpU+)@U=( - E (\6̨7ȓ:ݝz9I{>r'+)DrC̙@K_:6U6X:i™L@|gTǣzʥҳg$_IENDB`move=1000;blend=1000;3P2LB1SV SV k | jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??@ ?@`*@@#? 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4M>Lک+KP~BHiwW}v}ǽp$*u.wv,/xT]۶e1c0=!'В1d G G[9ܰ/K,a7>s*&`Ё| B| ncTVVfw4rdI~5X9e8Q<@{25DQ|5CGCw?gu7{9=._X~q@NQ=ЎpΩ [L4D^z%qov(xeeQIk[n`Y&vT`_fbeeX`x%F} 8#GwCKe]G21L݈.{DxжH5_`Ӥ(M"8Uu0e(p x[ 'J6~t)99GeeYvCU nkqlfI.N՛mOu9\{p8P5,U**xJoŒ|x<^{%{kN:vx<(XX*BYX>7u#9eETڊP\0`ƌH,:qeR!LoUrs)**0spcvut/Xu$ݭȣ*YYY__º;n+eňFtgzkLcHh P G8!C&eT dņeɨN=R.!/$Ҩ]64^(-Mѯ{n"HNfa*BUT%%7el^ R@\*Ì>op8n訊FiI1X|S)?KNVn`)2KU퇂QGB#!&ȁ{$qL]/"E{ڦjkegɴ#>m $FAV0 Zv'G4MOPNO5SjW`ѵA0 fZikkA7tm:3LkJ(J(Қ/.]*G_)Sm‘6߇x.Sp\I6, BQ6h<{W9|y ۉƢĢфݞLھ#F !i0wiQڈDii`/I_eiM$~=l` wPTB&ZCzMKPm@ʬusiж^.BTZeBX )Tjj+Z,4So_n +khP=\K6Vy잰bm {nGvVD>B`A݈>v|e,yXpK3k"\,aqm{/E֋spyFL}suP"dի !܎zjufB{f|Av Z~?#cgߊv d QTV^Cr8uMRc&#Y(x4_&yfHh@>2gʘx<>,Ubҥ {{j9'XK{AS@@]suQI/+*tky[ͣp8uŴ =}Y2˗~߮Z2( l_'y2SU^A{wI^/.̚]|YWmٺPgL?KGl2(C&i婬>tQEu6ϜH5}&ϵ#l90nN1`.9f-ψ@SˡTҮ], DޯwVc8e?+L%yt(1 T*64UK[CAnŐ1vV@OM / -i_y݉jY\4ՋG₅_! }GIǦ& q4̓@eҙĂ#妵$FG<%ñc"7)[pۡȷ w;O!3- &&u&{ n\%ĥ(*0(2 PP#X0<9> pWbyQTգ3L:<2eqBZ^FIAaFJTP$I[*!ar 2gdiʀL[MEBA:5c*BQx36#N8ӕn\u: -}4 e*eE3L@U]:R^868k\ggțjhdd|?ezu#J[ɮ  EQxed܎8ǣyA|:$wSYU>땭!8Cݞ?zM0lBz֌G<ܸQ7MI(cYRE;WogIU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??`zE@'p @? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9+PNG  IHDRc IDATxw|չ3E+%rlccC L5r!P!B$HrC^H4Jn:%^cccl,޶M;gvvWڕVdIf|9Y9y< a`l L-mui^/ǃA4;x!?16~>@AlF8v0t$C ^q¦do}drgq ijn$эcY&mb 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Y^ QYq [F˲M X$վꞃBA(g<3[:}c~4eÆ K}=\zX(.m:-u8qza-yhK lbF<_>$\ G37W^=m}]w+"̍dI!#yfK*;<Ųe@?IJ  fβc/qd<0msO^{9Sk9=CF4V4h iʤC[[bce8,!w̘p,kB|j⃛@#tG[{==W_}uK/q_GG/z80V[(C`"P8u;jremM@or_v[j*%sWR1b -{ؼ=&=ڱ= -P(,qkt8Ξem۸;SR #хĊ |̄|>ewϺƢ1-U(*(FCtI,2Mڭigv2q׿ի9;v,w}R'7i44vdVM@-w8 5,<$bnNٝ(*  IDATջ'cɒ%9R'@qN~Q!a8Ec.3 ͧy{ $mk]--4Ճm[j3alC< S20,zvQP5/wm5|,i4b4$l8F(F$z̈S#s}PVV֧zCCf ǁ2ơjTIyfˣtԔ:? r(K)';TOsC C% WCQUTQR굇iHױlD8|x5V .:Fρ^{-q>038>aGQx= ^> G$Q=&`.t@%Kx2y<$I$s!O3O&9EÊ-Y¶1MӴ L0M4XVVݱwjn}D6zdM\,|>o-wSkhc.Փ1 jw׏yEz=f5 hnʩ2|2b6{+=H4t]9~ge [nwW_e,]nӁU˾ߟ~cX9|?X8yWqqR[=*ƓGS<ʯ9r %%k72_t)L@~_>5yUPT!8[~qVKy"!-]]1BF0lWu_=LA^U˾@zG?/twgƗꊪ&$#,lIpK>1cgP(XF/U0OsϞͭ^ȬYݸc8 pxˀ,3 ??2ð'H=U't-,SGlU1'‚y}yrRmZ:ϼnxXqY>o5BTO_CQT&pHÎ<'"e/3\D5ww˜IG^x" +x=~ A u whu,};́JM'Cg]6yΊ8ql;; ,"Ě#CrΕLe2|q ?I č2҄q WsM!\k?N$l9؋B0yWtƒ+}k*goK[>[̘p#ԡO<Yreσ0W=UU EZݠJBXX2$ؔ`%ZJx4%1$_z#Ab(B{Bj*l<]$iE|ĘM?jضz6[5݈vS\Qpb Ym\BI$4ݻS(Iĵq((G0ȓx>M"LAA4%"ͦ%!e5?I >Ht 0#C<bTE#h)NO5I (I:GOXe3;A7x#HTf")+K5m!Ѱc/_&>}`)\s7n'X0B(PBAb2x{?GU=:0]xö-TM#_@^^WCLg  R]cWNNη/'͐QV-Y:e/u44 !l^DDw W}"AVNG<,p0i&fD+񦇬yPID:!Á'_;H t| @7b6s?yؒǖQAm9_\RZz5{"j*^~؍}jcܨx=~)e<~4'a9f<- wR:CWL𱪭&¢$Gq%姌J| Qq&ŎCzJ +dB>bcchɔJ͋() m+ &'%;IM>. CN#AI@:"-tDZ) ܾ)cp]16 G()(Va2z:>O{aN3t>дnˏ(B|=CEZ G{YP@cvĉurhXJ̈́I5sRTuͻ¦=i(tCwp*TOǫ]4Iݐo BIĉnN$01s]UHvP0н("uN'N(&Cfj̀yƖ=ۅ@ih;$7nX?@2qZBt! q%a L3N;A'1GiǢ,ǭ_m{L}!@N y'mRʹ E]5pv3Rāaӊ uIh>3pfZ;kرc꼟y=q:#'y &> EQEnNet5,=̙383TL8.XshyjlC$A4Z(P,SW %@N L9 9d@b"2ew|Jx_3f\Z/[@N :&EiQ5H+z'kI8ږ^z"&OcژxçQT EZЍh7gx.:wKIENDB`move=1000;blend=1000;3P2LB1SV SV k | jWZZ֩VP֭jOiA~!V T5!RZ֠RZkPkWj֤?UTZZ֯j j Z?ZCZ?/j j֭j-j 'T?֨PZjWZZj5/֟PZ֫ZCZ5*-j UPkWjjVP_/-jkU j֤֚֠T?K!UZ ֨PZjjWZZj5/֟j ZjkU_T5Z֪j ZoZBju/U֯iA~PZkPjHkUVAZ[ZBZA֠֠CUT5ZZkP_T?֠֡P֩ j֫WjCZ-j UPkWj$H$H"$H"D"D$H"@H$D"D"DH"DD "D"D"D$HI$H$D$H$H"DHI$H$D"D"D$H"@H"DH"$H"D"@H"DH"$H$HI"D"DU?֯j RZjZԟZiUT(Cj ZjPkKC֤?AZP֡P֯ H֪k_HjkRMj P_*!ZPZOUPPURU?֯j ZkP_?jV HkWT5PZ֪֡P֯ U?֭u֠P_PZ!֪խI5/AP֗jCZ-j U oj jP!'UTU?֯j ZkP_?Z*j֫jPkK!UZB?U?P_//֫_Zi֠֡PWZ֪j ZIB?UUTZZAAkT֫ZkV'֠ZAkUBRխWZԆUkPZ֪֡P֯ H$H"DH"D"D$H"D$I$ $"D"D"D$ $"@ "D"D$D$H$H$H$H"$H"D$H$H$D"D$H"D$D"DH"D$D$D"DH"$HD$D$ $X50 ,B%!mpf RHr$I$I%T+*$%U$I*$I%RIU$%?J%H|"UROB*$H$U8U*"" "%DH?JI UT%UUI*J%DE*JT"%UROBUU_TUI*"+">IU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1΃΃1TYFmse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???  $??xG@{ @C!?l?l?l??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10%3PNG  IHDRc IDATxw`?S˲,]cl0clZpG$$$%G.$w#\8r&$4ܛm+i̼?H+@~`ݝwyg*?kYב;x /?qCT7nՃ$Y9r|70x;5ˋĠ|$I2H;QxF q<=+/|+ϛ ICn/.ՍK.dIBd$IF@蟿1x= !дӝ_m=E ~="膆"+4WR|b/na۾l߷sޝcPd!_wLoľ?v!ò'FEqTY.AӣzE6%@7o_vM%JĽsv嗷^[BzB0Z`s[Ȳ9/Ƨ@apƽvrb& !!KRvg8cNX~ܳL@tU1Lr 8XE'c^;9PQS 0j ͢FԤ,$ɚT)4=ڭvkog7{7]>D Jm0Pųo0ƧY4{5 "EZ`dYAC@2H}ibKNq@8i/А%Ye%?>E#D0X@@%d'p<=$/kZ S(q{d 4- o oo",kE GXT1ar~G4`M a݀0 <6\$KiOCcν>XC0p(h$j+ߑkZ_ۅ 3?snu'uckzr"`}8o};Zp`(@m]E:K%dꅪj˨s<#FdpHZz+VLS)َwi7eLIw~S>n5'(:7P-uȒ! NW}A?m%&zNp1NWQ^@ҧv"Os4k𸼭ud; 7Dףu$R8];ā~I!!Mmm[um#*[m!Y*EEU.`pz>*.z25zTŅg⨹=IU՞$TTE% =ًw$ϰaBQ!CRHKSXxE1@(j_ۂȮnWumDp\5TK0ȊJ`(hn #2p٦Gk{5ϰa!uuumdg'gkKVIclc7mEud{0kFU< KXJI!|s Z(ЌhMA'Pd޼h34j W*.\Aiy=z Ffx 8߯_0eVfr7Ԥ,G"U$%*nYZ܎ʛy_a4qk%eO,)TQZv>m)Jum37s=&ay6 C#S8Ps(aWJ>ȲJ8ھF96a:zN./ocqZJﱍCۜLp!f˽ȦNЃ5- hRRS  45heoޔDmSH!GQ\hzha@ǰ. {mTW;lquEweT޴7(-뢧aM膆'LnNkUOoKFMaF˝vFM ;A6w["V74m~!=  R4,%c+F\ 7 7PurB6qHOqc{N`(z8&IsǢi043Sxx#U'))eY $<]trO\ޞJ̝UDo$M7.ciu̹4Ⱥ" $ UuRD!TU獣= tCG9݌}7FO=M3I#Iiсi\yr-,_1Svxgn7u9hЙ>ne.PEVx8S1oho_|cy fD2TA5'sTZD"Ze|p$tVS26 x_p"J,TUXɮU1u/W] |=(I$'Hiˋzx]>6x?{E[놎!,Q]wLֽ;<_Oe^6mć~\{פǁ}tj+bR:aX[9 j˨=ň)Hsx[ߑ^"Ki& ٴiK5 `-p;.\Y0h67W&&OYQÜc*d΢Z_`C=<~-Ǹz7uRQPŌuTT\.>?:k0`g C$BMI2<9F*^']90/~eLgQWgnߴ~z,BBrJ=FIVXuŭD#uu\w<ƯʫKY8&q=i/dR|} I[u[.%쬼0h {Uz̏}`N*s _l?ϝ׫W楗^jl direhF4 9.<Ʃ"qcfX3.V~&$Y"P.PK.ӯY{ Wr&gEBb$'OvZr*k><"ԇ1>ǎgeݺu̘1cǒ&[F=qDB5%ZC?`hKUU%@-@C;K|u2Rsxw7 viƭfN묮FF#LXAnkҨT7[yff2q̙3Mz6{ܹl\,eΠx\^fۉ75,>$I"PdQYUIUU%u+jgѹ3ָͅ؍j/$f*#ŵ]O$q8O`nY9-s(iɃz}-Y{49!EQc <?egEӣf9C!ΐAȒ,.j&L$&j!{Tā> M7b{s*_W={6|z.DJU3b:8ֵ֥zLŜۇד7!/{,.'nϔ: x\~NW h2FC#A+*(+;ɓg<h `ɓ̚5O?oSR$M8lfփSK"Cu|l*&\b544]C7hZ M #0FbIC>=s,?oKM`#qRǛo͛|-ի3g>(o)-e˸c:X! n/겲Ɔ^iD6ǰ-0zM%=BɽȊ~g GuChJڼF{`եhKa޽n YM_9s&lZy< m ϙDaD^ʽ:.ߏE ŋy83<O`9ܽkvpEWr4tu|*@5͛~ש{5 ƨi 'Jº`55=Wx-޽#GPTTD~~>#G'+t]p&qYo$N?#GhI > Qseƌ8ШYuw_n֟p-?4,T|DtC^v00j09a =qs&Ö·pС*m>u|VO~VHO WQzO]>C:@9eϨ93/a=K8rο9f ;ٺ5yC(nh J]TTr㲇u|Un\ )$dRsI'q[Yy{yA̝j֮DA @=]mptVOo'@ 2wtR|3&~eNS .`IdOם@rB:ɉ$RIZiHdl/C4-L]@}ՁS;_A?_ -9ʲNInVՖqz5qyR$" Nȭ00ER8'/ !JfJ"<ѣ1b;mu]<ɒ%vp޴2  27]~.yxÑ‘j&ܺj 7hoc#-9U=\^<֗&j& h!tCk7E@`t9>ne9l253-STTĹ?*or;n=C ᪫`\?dIS/M( xUMW;v/2s*: Ž%.y"=e/-.7k! K=ٴ!R4M竿5 bJ* Bocܥ,:3|JKL=C5 o^0 t%0GUy NٳgtRƏF-?$Il|1ʡ9ylL ;sGЯS7j|7u'k3f y3.ğAm](.dh[^2K͞L?*LLպ:^`K W?,k֬K/ixb= [zU<1C'#;τIٱD !Ԉ#Zs^An-n˹x7ٳg7n2ncDC!h !#+ 5jkl!5Ie?] B0~5l*'+pn~<^{k~E)@Se4⣶6Dưq.IdCSC|%8#CO9`+:}"$4[uL ]Gע0AT#k|w#t=}o6oG/B&S?: ? z|(IV#Ip@?5Ψi J%+-<@_}o`Wk) X4G:rQPTMӑk!+iZ=q5a idu'+خ'ʎ8>BvM }<6@ZhdTCQU$gE"5jS, 91Ai$'fqx6\8 SɣXuғ?!?{.Q()gcgR_ H:ʉ؜4y {G>o> nhQ>j86 &їJZ 2ry|oh|t]5e pd.D ϙ$e,yLX96m$# GTFε**"-y5ƥz;fD1 27Gg.9`x~C2GRur mϒdžbܸI=;6m2Im{#R=$'d&KmA34a&6Э,!3xN?cM$/yI ΢\AAV./B3D!\;/Bx x{fȦ?$suNU ^8{Eqṉ_5&3-@Cl Oo\^}k)WZş'w3]t!3qƒH8kDS> <'d/*SYUW]i 3nZϮQ 'pֵ7-h*_~9<ͧUxטLqqڊ:y:wrS'Č`Ǧ@7䁘MK[Zh;oIeed'ԔXNO%їؤm]߀ … Y~=ONnnH]w/͍iRJ W$Cxf9IDATȜNYnIVLN%j 3 `ImomJMk>ic9kL+9R[ZLzΟvc~s-SO1{l~)9J ȼGL<ׁ%%n)CiWNYbؗ$Jl~f(1fnJQ}PiքKbcB8,aVBogyc))>"`0+PPP@II K,[oe͚50lذ6yG5ZجMNqٶ,r$#2;|f?sں<˗/[wuدke!TM"F|.~q_f =:Nnn.?AQ+ЅFN34 <qlP_E[exDT|,V^fטYN_5F l=2 8z|WvK̜93f ~0sϵ?wh(LŴ;x'TҶC/V\m֥{?bPo3&C'7)] I ԸNj ! v<}T*y-[Fee%6l{|ܹ=S1?@cC/ҎB|_^5ɉ1PYycZ]mʴ6e9:zmm 5==UsSMd98\sMq2.*`ҪQ|roL)(IjN9)c.hٱϕ׿c= |1k%?v"+4uK=Ѣ]Zr6Æ *Q@}ųMSʋ?硇'h-3ۘm[D@TBUݸT7KړlnvSȡSZ<8@$jW^|/W_Mȴn4|ƎĉbϞ=l߾Eyw㪫榆i _99;{It*{^Zr6C2G8;<08o 0` aj y>kTyZ>~Q3fg8f͚ō7w:S$HJHw* 'uMqy=yF_+w#Fz(m"ɟFJRiTYTo!$Ybw-v*> l[Z _Vz ]YyA$i8Qe{[meG%0~66;x<.j}WxplqCYY<< 7|s]gspnY9Ci՗>$RCYfAAu 0;+ɓ5Nxxڮyq3ɶ?I,yMXV&U~ MMLt◿%k׮cg:FQ&' YntdW.1Lk:dI[$$+㬭Š: :{iwV&e$Q^]I6d_0gl:klUKCI~_Cz ww$ rj !"ғA;6#lˆn\0|V4'x C=kKry<=LtSo@1RB 1`N)XȎ j'?s$$oJi+M%$"H_*kS0&gKCf/}ap:~UdYAe'm.lל?KDrBFc%?k*9UYy&^bUљ4z% +$[;.+a)udIA6lt _u?BPzY$2щ-ݴGNV@XvqOݙ,Ȳl"EOvu_!ؚvg{Y2HIdt1fFp_"q2-M"Jqb>)KQپ8:Xx'`ߴ<̺7q /}I6šm5؆0bcf%PESSsn 2=o;v%p0r.ÇNFעTוizk|SE-eXBG7 *(}uaNsg{nh#~wB* Ho?xgXtjNW#InM̵5,9fxHKr ŕLW{'%%iPƓCC(@3VvgƤ*NMtwJא,+Uc:m~J)hg\n`)^@֭&ǐA#IO$='_S)$\&;cn4.j1{)^TԞ`{0 vF"dvqF`s/$yǙA? !Lk ﴝ\;-9 W3YcpY55-BTZppHIN$!zG?9{20qL0ELVM]EbS a#/?e6<6F ɟNrB^O^kmo+5&ey6 ͚!i '':CƠiQ6lk0;'=oŊ̚σvmSp{E[L ]pk8XCSSwˋI@]U/.mY/0 t#iD6j!‘O>,g,,#@ӢYd/N`ۭvlxs>ҩsZ/HH(jҋN -ybtt2RspNmLͳäsdYLi/t=f8K4%#'yl_p{[* }s,e^ aC&Aui07.dID-uvZ[xXyѽGJw83tMho   1ojڝ%W8R ]װrNq^kON/YnǕL2fڼǾ|$ qH-:#y pYlNgRƍkhE7ttY+"F'7q 1Zr().%YԊe--ys0Y03x\ňI@/Q[1to7`>hnʋE$"o'!= 7Z`(B# TOdNMvGJw0(-݈bfT<4G\4 yXx',sts.FѱG?5%h\ 0S[j <u'&żZ4BWpl'aق;渣sٯ[\B$,´IB k06Zp4ȬKzN,UOBt8; UX33}1VñKfAщB(v<Q-bM]^=im{H#:)yF m/!Z#oL 2dH6r|C$'f:!?݅Iq&61 /뺆8gvZmBT,߲_~mdeX^K!IM(4=+VLe͚ z0 -M>ήNlgl7/v7oq2/ss>ͩlgi1_ye;'O6LJHHQ‘2I(h gј"E[9I),n5{isYI1{ AfPʫۨ Xc:hey1Ѵ;"#DsڸE$lZ~3ؔ!TGf;,yNWQBTM-5H@!hVppDXa˶gk@<`IHjvÙ : MXlkIUuE#T֜lx=`KCU3X,4yNW^B]^\׬Xӛ5# u'*n4]otQPmrGJ2SsM hB' ŽmPZcbdمt.?.uM0|)9]laNd,zz$e*0 ᒬJ69#mpH+HLH<MrHdž,!{B+ 3Vebgcn9S> CINcvXϙxF!\I$Rl$L;c>o"ayy+]Т+q# 4rЬ1N8@g%O#_,9/v3=K 7O!9;sn]G(8- aXmΞI).ۇ 4L0\^DJ  鑘0,xٓGOm}-"F'3u(NrEtKuiIU ""'$HTUI$!_IQT%UROUU$I*W$I*I$*'"J*ITUI*IRHURO䒪'JU$RJWT?%U$!'J*J%P*C%W"""TDC䪤UI?UUW$$TDW?|?$UI?""UU$!UUȈI%T"!\?IQ!*'""*J䈕I%TH?IU(_UI?qUU$IUU_JIQ?J䒤(ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESYY1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg c 202cc3DG1vbinding site for residue peg c 203cc421~binding site for residue peg c 204cc5UXop 1vbinding site for residue gol c 205cc66U1vbinding site for residue peg c 206cc71vbinding site for residue edo c 207cc8`1vbinding site for residue gol c 208cc91met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg d 202dc2JM1vbinding site for residue peg d 203dc381~binding site for residue peg d 204dc4<>[[ 1vbinding site for residue gol d 205dc5[t1vbinding site for residue peg d 206dc61vbinding site for residue gol d 207dc71vbinding site for residue peg d 208dc81vbinding site for residue po4 d 209dc9KM1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESJJ1met->mse selenomethionine MOD_RES\\1met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg e 202ec1DG1vbinding site for residue peg e 203ec2021~binding site for residue peg e 204ec3UXp 1vbinding site for residue peg e 205ec461vbinding site for residue peg e 206ec51vbinding site for residue gol e 207ec61vbinding site for residue gol e 208ec71vbinding site for residue gol e 209ec81met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg f 202fc1EH1vbinding site for residue peg f 203fc29V1~binding site for residue peg f 204fc3VYq 1~binding site for residue gol f 205fc4 1vbinding site for residue edo f 206fc51vbinding site for residue peg f 207fc631met->mse selenomethionine MOD_RES::1met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESWW1met->mse selenomethionine MOD_RESmm1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg g 202fc8HK1vbinding site for residue peg g 203fc961~binding site for residue peg g 204gc1Yqt 1~binding site for residue peg g 205gc2:<Yu 1vbinding site for residue peg g 206gc31vbinding site for residue po4 g 207gc41vbinding site for residue edo g 208gc5dd1~binding site for residue po4 g 211gc8IKNN 1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESBB1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_RESZZ1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg a 202ac1KN1vbinding site for residue peg a 203ac291vbinding site for residue gol a 204ac3\_1vbinding site for residue peg a 205ac4=\1vbinding site for residue gol a 206ac51vbinding site for residue edo a 208ac71vbinding site for residue gol a 209ac81vbinding site for residue gol a 211bc1gj1vbinding site for residue po4 a 212bc2LN1met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESEE1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES]]1met->mse selenomethionine MOD_RESss1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1ubinding site for residue mg b 202bc3GJ1vbinding site for residue po4 b 203bc41vbinding site for residue po4 b 204bc5HJ1vbinding site for residue peg b 205bc651~binding site for residue peg b 206bc7=Xst 1~binding site for residue peg b 207bc89;Xt 1vbinding site for residue gol b 208bc91vbinding site for residue gol g 210gc7 1met->mse selenomethionine MOD_RES<<1met->mse selenomethionine MOD_RESAA1