Fb3.6-1h/data/swissprot/ 3OSU.pdbdupa 2UVD.pdb%V[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of The 3-Oxoacyl-Acyl Carrier Protein Reductase, Fabg, From Staphylococcus Aureus[/h3] [p]S.M.Anderson, Z.Wawrzak, O.Onopriyenko, A.Edwards, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3OSU" target="blank"]3OSU[/a] [small](deposited on 09-SEP-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  2UVD.pdb3OSU a_3OSUB1  2UVD3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u 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I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1G,.y`,.m WZ_UWUU_mj_WUj֫[_jjUkUkUjW֪֫U_U֫UUkUZUUUj_jUUW_UU_UUZmUWUWծW_ZZW[W֫֫[_ZWUWjUUWW֫UU_UUU֪U[WW֫j֯W֫_V_V_֪Ujj_oU_ZZmj_V_UW__Z֪ y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???jb$??C (@[0@?????@@@x@x@ ???333333?333333???#~j????333333? 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N@o*OEEcYPաbB* 4gXFdrB=iw^)$LAyOPL 55K1zL݃t!Z[-A7JX]>}qZ$i D6,ҝdz'nD M I܉, \.wgRe[6*^PMq㯑Ln!6I1l?Ů;;EB7z{b_'vcO\ gϠ9T)|rw#8ҥ8WƶRg1ݘTR(,|wHd" y=XTU݋`7>r$@^?4v}MGYd&|}w;7}I$wښ xXL|ZfvOg [_f~H,8Dן=+ qZ1$688fR^~Uw _콤GNQ*S褥N>2mNznŋ/9̳{p}KwYniIV,d2cv1W6};NBP 0IzG8PE"Qa 7 t}cԨױvjk0zTXרƎLUGw9aFϿD̚շ7d?t-@h~ E0K@#=XۈOH,)7V>u#55?٧߅[o]6ܽhq"8\TW#bmԶC<QZzz9i_6\2K&{"?ɹ~hbY+FE !36m}#mh4CE6--}7[.Wцwj3'z" 75ƒ%fogރnlvpx/@i^F\XXl;e)/9.owEEgw9}Ҭɓ料 7c HDzYΥu.#Fƌ[?BqH&? >]!JN/[8cf2hPƷҥױrbY1>4G$ҷ H>FBvR4m[ZZgwy%|1NeVz+7Vyu!sy}chvکz>$YZz b{/*ErihZVaT(Ajjp _G~o{RQ1toxd⠃n/y@lny#/Oa,5NRxq\J,9jckihv2UVv ^(gr M+qL.g'IQA,_~^|6y2/Сtժ[ݴ7leeFin~T*ہQSSAgСcy/Ռeu"N<>{}EOq>uV S_'Ӧĉ?GGQM+Bw`u4,꽁>pqEZܜQ:N''91j3\qb\;z,;p:_ݻۺp\?`ey&s1dHF9w"( k+ x7'|o /@QIVPUu5WwUUdrlFF)dÆ=矟M?j#LYB#y^`w3N8[?½Sa wKkzD!ݪ?x߱l˛: y˓y;}qc]n{PSs mm y4h'xb^{"^ByoPX%fʄԴzvXiFIiia,CcժNS Gy1e2i,yQV^yw垣w۩F(4[zFNXيt+=N(T$nB,qgӅH¢E5\>6ef~eay|aYfw T_2"=+[ GIU=2qje7PJ=/_w^M"IX&bIiׅH*rOlX^'_dtte677Ζ.KY_SJ! B1_m5rHxQ~ԱfZ 2|oLӓuoGZKytk:EAɃyK150{qX qBζ]^r܄B^.7ܮ|N$BLbe}knSnUEW4W hwkA:.@AQPQ4;u$vw`sn!Èvv{jIDATbe혝^IGuBT+NE0Z*N y@| :~|H%摈EKp##FG4i 7<ny$x}HlNIENDB`move=1000;blend=1000;3OSUd d  L|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"L |  5ʒĢT\¡D5lDhaSrkELeJJ$(墄S]52JhiA8([}e1U5uZUKc&_6궼uۚn A8%ʉ`4DDzXME٫tRƦp˭mR)XhԖ("03<0hh,xf "<XXD,-I@ Li(*so}DJknbXH1e/S[Ntۥ{=u\*(QK\Tm.@!##WeDSع[6e2 Fs-뢿yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$=?$-@(@Nb??`Ɯ?`Ɯ?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfacepPNG  IHDRc IDATxieY;[ޛ[e-Y{uWuVuaI`d@6x <&Yc4r 00 f"`f@FHꭺ2+{o޳!ˍƎ:?~y}Y5&>v|k~J Oa n‡[ǎϣ͢*$ ѣ|7VR)EFLmAL&w{to;WCS=q[e^U))!$Ϝ;GIUIҔ("d$ Q7G1 pmc( I$@ IoDxy[?qP5 AӨԖ0 rq|=++$iшtJtLӲ;$*[yTbiJVCeƦ 547G4E: c:{,qLQ1.틷<ʪ"J% u L.y|{>A~w}7i4P ȶҔj.lo&>/im;\*u<8Rr.G /\ "(bk}4Ea^;&ss ,b].͏|pGti4@h=J0UQѪU\0PIP=8`8"KGi I(rO"Yyp ڭ[|ˏ(O)߳x[Z3NO,:(>$$ F6K!R(0L k52S.2~1nCIʯw{,v`Z%c$G8ږR^]T8Y ) |NP L A C+ >ɓ<|s˳=^y˫@\zlj%u'|z bu:Q#"ۓ NU4eY,1sssw{$vya4~v$E>b1CAǸeuf8Dft0$LkvrRX,:?L{43wQiE},kb8L IR ~K&`e%Ѩ2Lq]lL*`ЦXM8r|$g;`nm% ɩK.WcərN1 5iaGM+i$IE"AQ ,kYX8L Ӝ"IBy0a{Q4իHaLq?k>C8AEJYr2c=EyI A-?xŻ<mku#DKل$j \Y6T(,EF 8jB,xMBJt+zc>/xQtW=KMjiaY6FyLtb)i ss鄈DKyRiQH-3רT,,$ILP lo>m! 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rB6kk:f|eszֱʔ Z _A1=2-if1:Z@!j[̺0{zfBrViJ-Ʌ$T]nqm]wV˻5jwΥڪNi[ ]`7˼o`鉿+>nYgO,VbCr:t : [cj Y7ofa.JkoV0·SZz)U !^@ 2al, H`Bd/*13)Dq1QHr1 ÑP5 Ʀԫi0xr<<̐HTu98P,hbWm"qng;yiEs[+Uz.C]ݬ.CgZ'Z֌$j''lm2|n03N;{G ~뺆|wgQa#L^juuR2qskjN7yke_TӹMot3}fw[}/Z;U/)veN{WͷҲ 䣨1ḫ³"'qKM..KK.4KM..KK.4KM. 0*]uK.4KM..KK.4L |  5ʒĢT\¡D5lDhaSrkELeJJ$(墄S]52JhiA8([}e1U5uZUKc&_6궼uۚn A8%ʉ`4DDzXME٫tRƦp˭mR)XhԖ("03<0hh,xf "<XXD,-I@ Li(*so}DJknbXH1e/S[Ntۥ{=u\*(QK\Tm.@!##WeDSع[6e2 Fs-뢿yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! 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I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? $=?`3@`E6@E?ޯ?ޯ?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition/PNG  IHDRc IDATxw|ǿ A⽖]Pi;P^, \ ,Mk\+҄^6 ɦ|&=3sf3y1EP Mhh"&TMӄJxPi4O*&iB8i`^]w`qa߽ KDu{/| ږ;u%5F?mdkN6N4|)^'ۥ-G8Gocgzv5 An&+YM@[ NG-\' r.2H) Y$xm;$gvqӖ*Y/Ȅ!(a@L=pȔgfG*L 벓lx ~ (׃~5ҭyq: _~WٯFC<.Oh|,> Ea;]S}m$(xYVoq*nB`BėCDV4svqˁH9C{}P F'zr+X vt.UP+ki"R @ ?!40!{ؖ|gNYV esVDv„@0BxCBϩ9QyR %)9<><vj?E; Ѵ 9;GNK jxVqVG2qݫ6Z g"wq+Ov׃O L8\x,P.SRg*%5TQg b"^ uQ?tH-2Vצi >e9NM24TT.bx]s>bAmbb뙏 2A ŧ(}j P@ewqη (,ց}ݦ[r鈱u xMD d@1 @,;Rjz//XX%XT,w,p<+E_E =V-2hD&o^:wRȀ94h)9h%['s9`.K-L] Yγ؉W͉~)~^farq>+{=82_wLa kHۀl."Wpp]osuGѠ~2fZZ(O|vzdUq01*)ۣ/r):ź%[ͥ|Az00CDtZ"=66P c99(/S~LppCpH@5ЅU'Vjn,"|.eWCRf&Gh~8GTS\pK%Rd10{fBoTwCf4݇ڡ M>O5Nu4Xoiф,vqS]1T≭-tk׏ltnٙ;`qNĵ&  $4H5'G.Nyyd%%2'GE[ %FwF#D H.3m8(:$dI/lGIm/`Y\%/h{Q%OWjV_ A`hUP@A۶$yV8] o0͡:pM\!#m җ/D>ZS`}pAo8cy!"^mcwhNƻzW7j^Q4"-6QQ\Bq]d` $ȾS?p&[9'ġid l1$408m"v'B8@LDs`e2$=OG۫l\y+3:%50M !ra36luKf<ćE-Lد\2?V_KamtC%GA,+'hjp@iB<" L9`:OqB.Հ1QyZgߗz,YҠ.Ͳ kOHoDGE| &=|U.(#@Uϋ?p8ă2x=>=!,xi>yq L[ +X6" )deA -gP# ͠x@Ԇwŭ>ԹA@Fl+Q;@ _…!9O2@ P@ P;^%/@D1o-g-(^GѾ{Ҧ$>XUuOAj2\ !t5(w!eߦNsz"Pl6~#keP@Mœvn*UA P<2*MMUw i;Ԃՠb 5?uA7;;?+;ѝ:R`6 O)@B*{ Q݇[/ ,Q1הY+>?2̸p/Iv;>FZ77]X'Tڄ<r :"v{< w=eYSR$l_$PON}_;y%HckuC<ᚙn_hg#?M24}_XM #Uď EХK svtg#>L3f.ӭyylfT>ŵea1 7_09 >"/y)lfo]9Mhb}J.㏤R.$07ccgF@r%kB:6D A._5)7c۪pX;8:7J>%`{N./\|!P! x\bV}˺20ARuZG%m aAUH~̿߾<Ԙ4PA}[5'PB5jG\TkS;ߢ/WQFAG5;A}]`6ͱC͚7U좣RO60!ٖ*ևpSɠ6 8P F[9g3bF=ֶP{A@6ڶm{X>$`W\WX`u 071j" M; ;OQIe&M. 1_*<$4O*Ԋv_cHE1xWPNͭ"8mYivw=$bB"> Nʆ͛u ^T?߁l£?y!bxhZ63ۍ@ZE< 3Tb_kTFfA-{ʫXjѥ}i6Roͣv!ӤB2$lIBҋDL1Еj[LvUk?/j+||A9L$χO.G *^G"/_8Ld㮗"Ɛ]onp\^Oy@+MNMT#jx ԟX C(R RPm]OB z.Ud|썎+%roYqBmGɈ /!MH  ß/SQ2EĨRXa"QR:P? ;qU9(JزG>YgpA*C>I섡Ir&I@a&PhK}B>r=QA<`;FZj໡@,YO ƒed^dhK/sBy!NQP3ȁk׉8*VO4TB/fGdf8Wd~Oc%Yfc xa{/*JUxgl37e7&H1k*N εo]L "$m`A .lXVϘ1'V;xK,wtb#d`G>p|/$n*3,uw K]ZjYQj:BfK"U|idYLwOz֩8HZz>t2}<"`nFdT!f ^DҁjBh끞~ 8XgNZW+jyD< \f{G'H2࿀u.;tUhբ%%%ddfcڇRLtDanpp#kR_f $?: Ca߯,C7o[A!+AfZ&6vGe{BΙHX~K|MOYp!I]f" ^P_ r4vI3/1QcF¹zK %/W'i t萬~1zDXs܅jV'EhW$!ݩ0-Em~/{yJwO1Q㾭n>og*:NFCȔ4ȃ_SIDATf +tv^~R?F<`o.eUyR*>2SK0߄u?֌|5z_Z{Ȝh K˂rAw=P`=-e )чo"&!o8oz;abd'i_ooj2[`:q؛0 PJ#Va'g釣 rdO st|b)+]A8Nğv ;פ.0HvR["pPQ[sVU"v$ʝVAXv1b 7-;$4buǛԿof|hc3kA¾}eap: \yؽ: =w Za30XD27_I A)@<-eb^.]YbUL¡2s&3TyZq4_ /R wLnmz8e"{[UxUguJ8PYUu!e 7/_6Ɏhe _\^ƥ _ 3H r `qx0z-LBQjIQTdY'CBCη5"ם S(^ǯxzԏfTUb|P[ՓHbܞĴȵGkEICېtW_s% ̜L6#!R*!ACJ5 a`S0j$ Q"`TqE1%kɯ=$L@(-Ea?vm I8'm=bڶlKָ?F-c Q,sAD{xO+j$pn #x6 pS?BTP?#R=$#; )^ >."ؙ/+@ #r7gp宨-t)n)SQLFT8Dr}:@ yK[2Љ4#:opAʓPdc\#dUAP#X![2қ[ !8q+srOo'"B(,.Ep}8U+J=}K=D!*¿IMZtamN8Jd66~4!`C=V[.S؊L s]+$Ⱥ#Y x\06{fpڜ"n/b0Y'|"b$x j`䆈C< t bQbJbt!;?bE6G\oK7'][4.^YVd ێPWCtO).q'4CM]7V4^iBqYPh"&TMӄJxPi4O*&iB|tNIENDB`move=1000;blend=1000;3OSU*d dL- H$#    ||  .1 "1Ll")Hv$B/<u{{^5ּ `F 30>u#߆y@BS^[_xr5#Gs}v MV̸z?mgJV&a}uW8'V7?=sfT)T|ظV!DrRJ7 >J!Q]X~J@maQ3F;ajLO = Bp0湌Eԇb- "t2(R Wu `}㉋-a-E6 /L#𰭃BG5m2 O{Y`p8|#}+ r"JQ7QpzwsX!' ‚Gy8=8d #7Nr8-8`|,@#!xE8b8浧UҲ([+i%s_90rwض2 EDp|Oq҇6->qͧQ"2b!e;uVH2Ly$P4N} )qphQ h2)6˫n^/+60eonxԖ5drXevcc}2C!0of˸wT}ADa.қWK;lVPƟmi Vs~`hVe-+ 8qzD^\  0ÜBt@LyLzw+vK{+X[MrV]췝S;3ߖw]A~Rjyjf<Ɵ6 T@%kX-\tdBZBƃb _{3y7N'-!diJ y ӖuCO*Zh3Ki) wV!B!yR_T0@ srb=ڧyͩCf3{ﴥr7sU~3Bt[u:81MKƣtRNT;`xJ*TRJ*TRJЄ+CpJ~!pԩR @-:P|^RjA|lbR; K F'JpBF BUA 'H'(eN"=BcVt =nPMb,qnUZM6P:Xm!¢pg$fe{oyʛsߒ\N]vms7 _{+圳29Qn ϩ75))-w(7KߴIera%]j hrܷ|3yJVw̩|}k9'!PvȰbc" Pi JG&fBXB&f G1:θFfXzueǕ&Nt:T[m][;i]LbA6*4}m7Y*ԤDU*F!1V, $'!X%IMXFb|bD)*TZ7 .u[qS˭ZS:IBQQ 9)$* JHbAn `zJl$ҥJ|visCR2GaX QqɎ)B9#CaF+8nn^tqe'NL'IɈq1Q9ԜT&M I̎<} O4F"k&Bpȱ *O$R5aP+]uIߜam:Umjn م1[l:(E2 џFk!eEՋ3 GR84p:eS*8ʅ #5 D(ѫdДT= D1ӈМBn9&4Hxyy)RR4/Ee'8 u<WQ'nc];󇡇AJ` 4(BsV{1Wg=rتӗxe"|:Ŋ`$ dU E  ]O9MJT_YyXwsY3NTmu3 )$ /*S; yq ߹[ksurk\ovq}\sݛX0"Bhc8#ìʵ T:L⁃yLBnx^&N,Nae ! rB6kk:f|eszֱʔ Z _A1=2-if1:Z@!j[̺0{zfBrViJ-Ʌ$T]nqm]wV˻5jwΥڪNi[ ]`7˼o`鉿+>nYgO,VbCr:t : [cj Y7ofa.JkoV0·SZz)U !^@ 2al, H`Bd/*13)Dq1QHr1 ÑP5 Ʀԫi0xr<<̐HTu98P,hbWm"qng;yiEs[+Uz.C]ݬ.CgZ'Z֌$j''lm2|n03N;{G ~뺆|wgQa#L^juuR2qskjN7yke_TӹMot3}fw[}/Z;U/)veN{WͷҲ 䣨1ḫ³"'qKM..KK.4KM..KK.4KM. 0*]uK.4KM..KK.4L   444 4y0H$ $8 <`0P(Â@X,0$`X` 0Xxaa"$<0< 0h<8Ȗ(D$O,Î$䆏$HcQyP Q'igYiFQEqq0Ț($J"pH@8p@p1$8a8,L$L$4K"X@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; I's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! 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PekW%w"H~NtODRГKGRnpP' g0!z&,ĵX݃OGܼ{ AI~W#GNBB1RDZa&QsqX[o=wvOn )LfO'`u*U@-LހM)q:˾iԅ*, uC040u"'+r[yw!ةI?0*KS||@ "tZzۼ-w͌`P~w_»Z9D\6PUwmLw٢[xmBI!Rr|<'R Es%y&EUŃWQ}xU٣X+׳I7]EQ=Kk{呛nbgK?HEh6q X>0tXNVrqb0 jVe˗|ߚEdE ^x{7LYJxm!QdUY8A | _&GeYQ9Te\lXpiXn@ʙynyW-^o>zm HKD~ٲAФEb:jIIЗeOY+X>>R9+x妞q#L.Dlܱ{x<_K{{mB2f'iYx sپpi&AUxA_>oǏxRXIϲrZQ4?-aiĠ4D/*wxpb7v% ξUv3v9~gXj(QM7 =pϯԗ8XIpƄ%Vu[Z/n[8YV\cn)x=~L2dr{|i/Hc gr?Be ?8{Z;9FQՀ Y  +GVF+A|@zKS^^VB6CȲaԆ*uCM +#|2\sx=~*kYݺ^O}RxfOgZP8q\R7/.$ɱ-2G됐8WԾRxjJ hu&̬iolLn2&'ѕ~>ѓi(.bpK 1.n LHExo]ߣX"DƏ aj8qGO|X=8mU%hFX^WEV$h}KXdm}4(>گs5. jK r0CԴ_*!3G2e?!V.: G$8r<{b"$8ԎODH݁)Lʪ$N{8pVGe9\~w&„c!Λ~?J+Lc' 5k; ddG/pŧhg]ڤ3(o$GNplYߴ}u{uh 7^1p&xbsv⛊ѴX?_ZxLaڭ"غwMߝt=}IB=w2j4sWq#2=6Ѫt;[876>>>k*@344=?i$9Viwa:=L^Sܵ6yqizO3!8XǷͮL^kt2ՖQæY@dR1#f @B@?;<'/yJYtV8´_{O*JBxhdѓ;i# -UknX J: -X8Jɝ@׵>OKvjpz1I]}=l~Ooyʪ6+gm'XC~e[b][m[ Oi+IhQ.YN+&{tԸwo%<XhI7]_a~ÿUPI9=N˾)L')%'uoNxNUH-^+u^.S*_SP ! ??}F Ђdg K2olz׮5sȒGgPd9IDAT7ҽv !EHK0u #g//O2Ed ;=0m""K 'K2Xxl29dg#Ir׽bQU'+YWm͏VIDcB5lC6Ђ1 w8A$͜t>x#h Ge琓OvF>ڦ S.ҪȲx,![w&h Iq87Ai՗"1 {09,;6TK(\˺-Ӫ,EV0LS#0eG[=f D!‘z3)6cfPd{-V3۾QYVؼ@ỏS S_v=o_9Gc1drLF צ[ohFMPW$I:Gcpp eU Mk[8'H8V߄ڢSh@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???ۍ$?? k'n:@ X*@?`"?`"?`"??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2 .PNG  IHDRc IDATxyչtt̰ ; ;( &AMs7k$--1*Q`DA@d@Y{|Tuu=+8]sԩw9GIb@F> !L3s{=M0y%Hdo&+=:3$ _I N z Aeg$ ]t 1I;;3zBւ(jA%IA a`:;~ici6bi")B{5xD c !{aӭ#$R=,_jdeԉa%0I|eBt]G#ơ%);;3݇ؿ&->I`"L`96yL(e(n]XܶF *B["$ϚTO?7đ~% =| a˴ڝGnܲӴKOC3O"), B0tX]DGAX тD""RG ?|:V$پU۸ftSrM{f՗SWy2/߄4B8YH EHMT0ܟ0i 4=,EqH.b}*.nQ~0i\8,H=k0ɲuGkg?u$) MDNׂF?cGy}(*PkS$EQP$utCCryK=ĈGνc_u dHy5MӰ. ^D '5Ѯ_G?@&?>oPMTQպfz#$ I@H RiHC M@?$)7Gv%]}w(~s'\zlX8$a}sqG"aanw>Ϗ'F]ad۾K$%1qL@QDG@V{buU &0xgu.~'dɪ6R&OѸK1M4$nhصo{NJ}'J ¡nW;B8g⫩SUfh( U5Xeqs醆,Ů>+i!kL H=QS@ P#?p0]~'d9pxRy0}00l d:vH_o4M[WqCxKJa"p χ*}:6.mF ,Y04ٽcZG`H1RZEd‘&J  3{%=S#) CÌ:mctdY& :93A%(Β#zOrT >c̩7?9z@E7?x< l-DP\5Wgf) I6y}̡ZbD>d(yN6l_ND ١c%LoNLv6>)1Զ\vE^F($b$XhНWׅ-fo UȶhA‘&uM$j3fhzMb'nhkI3a3i 8#RbPYQ& S!Fr;nxCQ^Y,D TՅj07i/avYV}I d,n1~O} !Koˏ*MBF¦\dzspTgOBa<&;J1eV5/l䙇d *ёDUB$Yf/]юX)QIK4 T-緩s|?^! eݖ%-֐tϵfEuRlSg\ ԊӇLarڨ䋅iduEQ{>En~. 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E!,j6lo\m<j<'6ٔVc'V=/=5n ;"oĦM$Oa-dM h᤺׋@7 ERmcWZs=u>]WS)۟r m>ĚM9a=ՙy%HHGAV+$K%iFɔէ|XQV+DAm7M@=RVA*vdlFg7W+VgCWe'Y Œ'^v쵔8!@ø7-[aZ@ݦH-ܒȒ\uogr%.Y,$5`2rѲC (cYrrcWܾN[G!О_  WQ*wvy+0cf#K2nwig$u\GAxoBK=G04Vi((ظ?z1CNRu݈T7x:)ʒ$&7:r^͠I%ѧG!ف|G"(N"vi1k{IlvGR_ YHٙy OH~#&r1 Jp$HX!J:!*Y•h@2q=sp#^])5)6>= F˜%98cfDW86uX~hпi[:jCm%DwmRՇqCj;7{>oTY` s~Zh8,M@eLa UځUp. z Edڑd=CsKͰ&Xn 8.T5/x>K!YV9}ttV#R[bȥ,oϧ)OG7wl9^|"lo(KuR=HLI; *nuF7M7;'+ȲBK\?59vez;v_=ʆ̀wO-Pr{RݔWa{PL_`.ՓnoLK#p8ۄm Y; ²{}- g!BK}$k'?ERTfz)ZM ߥEߚhUx\^gy Z9h!gVZ﷓2̯~hm;ֲ]wl.Z$q}I1UCB0ug*TM7U,ʚsC kw%%trN";;E&T/#+.,@Ǘ 8HD(Zc9DМUhdb|XRa YV0eذa+QG$jܗb{=lЪ *g^ta7Q<M8R]DzXQq Uu&KciϞjzb$J% ɖ@gUqHft uƻ3ܮ "nj7Ｗ#GpyA#-?3կ~eEItwetwQfsLTw<@vyKZ|=`ߣA]V\{"'Mݻ,N[o;wj6|~ov,%u#=D??ܹs4w}طo~&y9'+RkTcXjURH C%n5gk`@.)|š瞻-[O`x㍄225]veuћ8q",^lm=P=ke>j:Kgy &7EEEz뭌9|b$,v0}:yE%L>2hw춮}\sؾ}{JxxxGXf S2& nְ|qvg̘sf8l/,,ߖ-nhGxｺKEQTTĤIx,s<@{Pn ( !XĜ6m+V0h +5). 4-UWM`इ̬Y(.._~ >}W@8*fM4'clp'uǕɴ7,Y7I H lk|ED?7sLv֭[ 9<#L( G6@:6oJ~莄:}m 'Ó7# n%x} _htMr` pi>ڻӚ:8{hʤbќzgm6<̙3Y|yuGۏם7ÏǓǕyY'>t(=7*Sr|屛SL >esR]]ͻY;x"L/B獣dB.r^}yr*x7Z|uFDΘ1Ka'!'@􋛭J &пy랶Z<ml܏~4n;}1kV۶mc_ÈĦkATTT u_~rrr"++ ݻRI'ѣ?ZÆ SNaРA{MNhW}ƌI=C|TWG7C`&f&ח~&L%|<ә?>J^oظ.q q͸2(--B`KjJ 7ofrW0tP u0o|s-g2{wOJY0,[g唖Ӯm5,o}ؽ{wC.5Fsw-[زe :r?bŊĭ-wywov~O4I<@ݣ>Zgpp(eKYl~r;/_t/(O??)z̏S T:_&cР[,:a!)@aA8~(E[3}^o &pYg1h St*ðq۵0.^xa~N4. g~W;o[ξA)c_:qڽ+8&?T]Ml% ێS={veVXQg_rϱdZ^ye e,YPç)P]ѣ(*Haarr|{Mk3hwa׮ͮ_feA\@S>_ 7#-G{oM?mv=(@C˖-_w0 8p,\#>7Ir"$s 23Ž &L+&L[y fb„~,]{EۈjkC ??lotHꭁuJۻ)ick]1`}iGeۏ۱E1 8Qx✔? ;>4 &#/B$۱)04tۡ>4@La"4 ~rx7s+)O Cǥx=K@DcZB`Vlx۩틔}Ҭ ,y Aث2G7D&~CoR"Oqz:aRnj#| DAO(ɝF B@>9nqN0tLioB)7_=]X)?l>]*>z1Qib^C̢G_}FHY1 ݈|+eקl۳q^,y'6R'4=lo'v]νʿӗmV-?&uyIENDB`move=1000;blend=1000;3OSUHd d UUUUUWUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUL| A/CZBUVT5ԇoRAUI!*TRUAj /Z5/R!RTJ?USUT?/AAR֠j֠TP_/TH$H$D"D"D"DH"$HII"D"DH"$H$HL WWf#Gꪪyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???$?? /4@A@:@?@V?@V?@V??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3%PNG  IHDRc IDATxyTՙz߻f_A 1FID3q2;.I|N2YL2?&1b4*q.lHw /UqnݮjTuέY<"AO\@iz9-"N 2}^B xMvf>uǪFR ry71|>RI=`$Zؤqs21 C0ԕ *t żJ)PWMA3e\a詹`{êT~_&A(xL/9Y!$pSqZPAœ,'ܝp%ҌQe@^Ӈ'ËR*謙aY!ab&a}'3e\Lӣe]øՑc'ßߗߛWcvBE}!AѢM+? aH-^ʀeaT;v4tvggeeeߗÖ6OnhWu [=sZARߞdscE6]ɓ~~&Kꡪ^JAO8HwǏ &"ßM?V݇ixYA~F#e0 Ӎ!]!B`5Jgz\CЏ5jblsJ{3;wo.L,0oGIMvFdee}{~0 D4aK ܳcz^ ӃtUaG/K 'F]vT} cv4ƲCHee[t  wc!lܳ7vO'8i/B69(w[f))ߗ@BK{Vn!ßŴyda;D(ԅl:Z wa izX35b8?!(%]" fO]"Xdd=KISS0 Jm¼ -4! `2"􇙟[hh>BNf!ٙw5꽌$Jt~N~Y4TXNf0rdj?4Q "liA㊏Oozlr bK)-xם(J)$v|v aТ>-τdeP -LF &a j+>LC21Q .;+T8-=rL[3Z_S "ށv_֩!h?/Ú_ ?܀aDfn9s%Rdκ!W"U50usE p`D|<Ɍ+FNV!RڼsTqrk*F"QF*Rض,)/pr̟uਔBJ'_р,2`]J|)ZxL *\cPĈg| M!ßR6|.%;Ype^l/onXeϟ $ g_,؎wƟĜVlbRw֖6!s?&]?(TÁ|o [p5!-R6[k/Eg\3pєRTEu^W5z|xM?3I0"/A"XxzYuZ9j/([Ŷ^p^q,(fŷ"j8Pk $݅ax0M,?熄Nn81^0wϸdEU#ώ?aQYYɢEO c)}݇1cB1@VQtXE){mcEt  0 .Y9m(IxZ餉TʏލT1u\ΘvS0sـ$aǝAyi㋧@'x:~g%m= Sq #kIMNۑJڱ esJ0O(Ai29Xvm?-)fM^LZ1{kq("?,64X6s\΂&΅,))?&;sW`Y!V aL0SD*^Ā;K4*" *# O7O**ʹudrn%ծ \"jn; @nVҢy-Yt!YK}~ij46p֬8jHH8 K~W;-+;zJ -'#izQRtq55-r桽@k0 z"+hh@z[ZuK.G2wvmbќhiImʒhvoOO a[-FeSO&îq~gcNYr8F];iR;[+þ$$_.LRCy> Q(7)ktǞ"XREsnxyfL,M{V7 fbY kX䳼pc:wx"ޅyNtEs[=g2LO_5kqjwf'=:H{tRt;O4M δ7ۻW  я obY^v{C|0t8Sgȥ8P64* EVʎ4?GdMWx뭿OͺuB9d֬YtuuQSSÝw#/~~o([!v/u7IE׏ſȒW`/45pyꩧs0w= pVqz)=##E8erR|ѿ+țzn9vá101^ Gr4b{WBaa)<4\w]0lz^HgIV K<|mx Ǯ!Ѡ!뤔xDzeJde-V0WګJ$&c7?nee7!tw;UM.VJѣQ}>O ? ԳƋ%AۃX&Vr Y1t';'7ؾ};?OiuRf}cSo)?BMM++W`-lqԵׯ;'&HdW@7B4űx65k(P7ǥK??3KBFyf@kǗnbdLE*;4`#W=mutt w]YNJJJJHaVg5saWPX8p.Z}Q_ꫯI[ՕZWD(=n=4ֺGxxbǗMC +?>+_|z(euPWAɒ7(EEEr+˗/K_/:|SJXvqp>S ?0jБe| r2 [vkkXveF|>,q,?~՟{1gaٖ 4=S\ve90 \uk׮eǎ#&b ٩Zg=9z% ?xVKBD$\p\ve\tE{#n۸{4y\t`" r(/p]2,,;Dn'UDƿo7Ə?]AEsE_0pJڄvPht'(n`lڴu] }0{dgQ_1I`&p }|>y7b~r]w%]0Mo`? &;fȈɔUN$W?yW<.(d\z:wn_lqr&'MnV1 7xuqgcǻ;pB֮]w.?b[?>tt.Oy҈g+ݜwѭsN#'' ߥxz|Korg9Ή*ym+8zd񘾘.艑bܕn~u:K̽u|tP'~omuHYݻ#-W@oRJQ usFV 60nܸ/R1DX vB:6o RJ,㋧-XkGRJʊt3xXl^x!===\~JI: w C){hc1+ L/OMdPPN~}t.’s!="nÖaA1DGsͲe˘7o˗/gҤITUUqۗ@g S-~{؎h2R?5UN 3xz>²Cnoy"+d3K֬YÔ)S2S͘lT :m'w%W4 pE!ޠ[n . ?NG} 39n}C '!snrd7}MMFBߞ$$GMHե_ZkO+;:H`G":o/.fȪ$흎'`b;$$6xF{,A8v=u]W /$ !;oѣm@J+sr۹rDؗ;３#Gh; 0B!}v2 4|; \|9 I{Wq$$k^m0_>{4!Oੰ0il6HapXTRBBv{q6w͉)Mk7o~(o{曇h[:wΝJ-JF㏳e˖OC^~gӟt|V D~D9y,-P@ar2.t6OQ~i`e1T& 1{~d5&fhos"vyX]HJR&$wu/B\̌iJ,+Uq5hWbIOG,(ɾ{6MunyF[GGqYP! aS) Ml18g+%a}^ Ӄ`&14'[bxXtcz@IeK[4r3ޠj C`Ķ" aJazn40.8 A!0 ix<:@'L<1Z0NRNI#,0%m=xNS<r‰–e֯H'JI6R gkvRs {wMN4 fd݃$z, Rp$AxNopC)c$s[(@Z<5:rs @ ; Dv m$<2yJuiBȜgVO{]Z@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???-%$??@@9@̬*@??"??"??"??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4C;PNG  IHDRc IDATxw|\ՙީ],ɲ%]ؘz wn6l II]&ټI@  \pǽʶdr?νwf6y|F3su93aD0_ZXmn[taDTMyVN_](aR?~…Y{LtyEWk>X"\BۧnI@m[9ϕ2{lEA8@H!Mopro?8j>EUTTWh,['m%maD0KSިzOW(Δ87J#c{w/9"xgݞWS5UU9ڰ˲li!@UBvz&,]m[&^`Fu@z(9OV}-%|BVDUT LS ,a&{(OAviL%,hh:7''mȣqEia)y"!z HÈ:;^s1BSun^XE=hB[6Y _bk6jp0u#ɠwvEYN%8*Gv`Y&+>6qHOer5jɀCg4Bw٠{u֢qY٭O^L,^|q%xؑÖn'HxLwl`K$JS^^13'\i)4u aꘖi>kdʸ>і:1i5xM打'y%,Lab:zk۾TrV,@:rwy!0 ЀtѮS8V}ltL.`¨s$Ѩb6X_0\8:kt-->jȀ\_͞t)?[ v8 k+hKs\̴L,S0t{o_%soCXIҷEu#[|S-斫a3DVz+F7}ENQU4MW=!7b$N3i0PhKVaYtw?3qWB+W.{?=A'k.Nx/$k\#w=EqQP\=QyX[wy&' ].M7ڕ?`7aꨊʶ={wOdJųnrS}腮&Wq0ѣp< 7RY~Ng1": JO7wĊ_4#x$5]+t / #<U_^[Bՙ*fOu NZ7 g֤BX{5g'e׊>_t_F (+L[xsb$/]BX|a?R<W1P؟[%q8e*DG Φ>H5O%,D @?فB`m@@k[+ue +QQYmߝa!6ySkmj*KcQ|TUeYl^֎8UzӛIg2aZ&C7XER`WG΋:V~hƍA:9r}*Jkm\tqg'܃GP5#|,[lRW8}TQUmjC$ 9^YR4nD"i&59ʙ XiO C7!NpoFZMMtK G%ڈzhV_@vfYi44AQ2hsgݪ IsPpy&EyCmJ܁B$Ch @$Jh'%?n@vMp9FXOJ!g,;NKKpG:{mr?@zƘ,X0%^iym?>]O=lٸ(!3S%N4z9eq8ܰ&cK_eZٷ~٫k*"/4krw'l]Ii( Do7Aq拘E+FI'O*/x( ),a!셴h\@aNtjPWhWda¨s,vRa{'H/(q5v1²X_*@ݱ:-؊F툹Ԏ8'ᄌ<8~&{ڈ+غcZ>#} Y: =XMPyN]Q:C8"wk9kÝ qJ.v(h`/>g~ꁺI`-^EQ*I\l븐^[#Mm8&;(z~?zG%i2LvWP@U5>\~RY !t#0eaQ]FZ82Ix(R uW,7|կ5t K?~`Mud$!9Chh:b*^ݬԓD %( 45?ml:>۷k!BR=8 y<8D'|Gj =5=7RdKѮ{;s&]Ej0 EQ\0]wҖfeJʽ6yN rB0|2[woք˨*!{CwU2iyOioL6{8ڰCv-b棄gSX<| JEi;,z=de2lpu>s7!So1`8R.Ħ$CrخvGIOR8Mr52*c]a*ht{O*gQ? UQ$|qimm"i9nPZ4ytӖYil߷@~_M4MKT##|_qy} 1'8v [s4TU%#(=|zX.]9nw -cen1/}GY@[t,?Z2-!Ϸ%CvL(:7?g{4/>o'J䉇BK]9.dكIR>g5X¢` 7=61l;uuJM[#Q_t'&e4ss~TE𨞄lR?crNF ۉw=B+!ϐAy磮-5%şF]v2gB6ţy#{<.'GU1X\][_k= X8wn}asg;"OEU4<U(~w^dwHx,Us|Ncy{cRXHmTQSJZJ6Hunc"oxX^<!,sJ!]DBEi-%#{v {N·q+(7ㆄpޠ? lq^`|V'׻?Gq>nŋ+*!=5v$OCӑn/+EQ^RdKOu.'RY2%zxai,[?;ڐ qbGr?O&J H5Q=뺍 =wuvh࿟nvYY6OzZ.emjx#BP\0 !#rOjF̥9tQS]M(*z@"GvqcC^(oxW u 5 pTqn*/{^;79Ԁ:EV%};]Sa7kӬ0('I⮪1AϺ&aHSJ#'wHxě=~ ʫ@QLp?`ĉL8zFe2 |44Kz"+\㐨~KF[[8, K(NH(0u,H H*C∸! DVW+Nei-mxy'cƌaƍp݌}5SsH!=5`:ՋGi}YGOMUxKX{L;:3==ﭠ(*9eΘinFZ'iCUe޷%"3ʊ/3eb~ɯ+1rH6_w?%K|Y<7@Z0ԔLR2yUs$il9sqk'fScVSc Ev9cEehX0hTb:eyTM8mhƍI)TUUukǻʲ3hl>oLRLQ=LK 7L|ǽsHC}Kǟ_D1FkӖ<d`-N,W_}5O=Td9|~o73DܶԖezg^ހdP8,[\SHx\fd!>Grec}n ӤI{pU&ۏ ldf1J4mw]*n~\~Ԉ0gl۳Z&^Da"z h]7ANFAj;dGbKA 08 Wa&~.۶m릇(rw<$'J(gg4on"+[U)t=Lkpe9~#Nm]b;kY2Q)BjO#--޽tM<+Ur!>EmN栄N&ej1y̸z_2=lgesBӑHe8hiAOѾ v]!2ߗMCWC^!.B,bbzq7z113'9C\0\ ,p4ڟXo<]bf~s=곫5PZJ6͡~44UzE%3-7cq[( _'Ej&\(^% Ŵ&y}3av40`~|AVt8T<7.@RF '+JdmbLC+۝3je QI|^?i[b̭0hAm;#o\vӃ~tZBc&]I ڑ=Niծzz[vĉ' %5x=8)t<~{23̟S&,,ZN$W( ##˵,\Id!Zz uGg̈́Q:Nڋ(eFZ'B))RsWs73k֬>7diYixA2s2),0M 1Mxk_bw~z[} 7ңϪ77܀V? vCaxDl괄8k֬q|>+&_;:16б(ԣ47q1R%1 S2jޕId)S$ɟ'wһ}CCf(<+:ͭ'U;DQy.&\=wg͂3X'o|Kly`"]xb[*IL%=%`0MUyo&=)f<>UW]9qO3{l~ yj^.-Mp|̙hwfq3fߏ'aj\}{BA[OnϽ eyn.9-ČL3!mގǀXnå.w65cΤ\[n{{!5Aތ!6oTEcE^? M->RǨcXv$XieovNK (yԠ6cF 6^Jj\y甞-ъG_{w}>0GEQ~PvN#/0{CQ5@D HsGvO8N# yʋ|,[J(hKM!-%R2j~T]p}QVV֟y$x䦢1cdzz'r`Ikq!CRKc(˔1?p#t tc 9||@-'G[ZgWz[2tP^}5Ѥ:R]hha55ܱ4Ĺkذr`=&y'쒄B^'sY b׮om۶1|~Odxp|?HIIRHsr!^6AT $Ԉ!F2~T@,Y$)t*3fS'׏?`.Lwyg׹~ }/%aeل8oQ=gi>KR=~W_}E%x44bW7nkMG>I[[[mqj_[D1z41rYV 4Zg_BWoGďA >I奉|s*?~}.;aGm[驹x~ S'MGoihb۶m|K<1x()ѣhs= &55kfEaa!dnH˥h.*C[HK&n췧_wh]py'~QqLd:,^{ksĻe]x$Okh~iǎ7Ԣnk\6يnDݴ'~C\vi_zpBۀO>K/2;7l'c0嗿dŷWx "yBo^ m$g$ƛt߰# v>w~=~_NI&:{K$-Nk )#L !k(!Y40-c9ٳyry?%fLrJ :de-ZZZ8p;vrIg#`OR<ƝL!mxE柳tv_OVz> M}N.nV͛'] uqȐj$EapAu[Aodr !#*VEu#FYG> VOUe MP#]t+b)\F;eO4 TUB`KWϤ-[̴>#WUWM?xƧde>ECUU,i}0?Cuu^- Jٺs]-W۳-?|;Ԑε^լ}kU0|xO<=H=w$/z_|?s ~|>҉x+香>+vb&nb}n̽śH7feRž[7=?MX5|7jdʋFeJz>-[l~ ($cQ^2;gYZ}~ ðᎰukFO?=HEE>Knou#l?G+6ܣ91׮)!Fvz>eJVC-O/>,wڧA/Ε |sIz:a9f$@gi|l'7`eT*K,J)pbܿGo,?z?b향R]RE}w9r\RXEQn]S/0@n ,au9,leSI('Xd޵7jh&g 4~7eb>J|1l3nlXf;L[z6NF,]jSݥ+6emS n,eg;tJƞˮR4B]#]g k6evX G}Ai 7cYM+QdA|E\iWǮlM瑔 ^_kuHA)BF^_%0I)\gyyӣkvy犄cvݲcfK( 7mKV"z+HC3Dgt/(Ju2Y/'5eYq¤l<ȋ?5*Jk9{X}, GVugwSQZTHB8 [9~=r=G1Q5Dk~5,#Gwی6QCg?wɛ83u%IO騪3/k>]Zj%}oDމXo4#'c:00jgׁ daA{RJ09|lWV}!˩h-εmO $&wZN4H8´:_2cZy˜ayf "5qڌO[;%%A/jIM fZ#M^rϧ/AQLR'(/KQP snc`1-ְm[1(iy(ʑ{qYt 4,`զ74H)i 7?}甎 O~V 9D0y%攑5˲DF0f p$D8ڂnD0() /}Kú0k.%5yi 71/ō(UG-N 6 C7„䔑 *e`X%m<gWپX\{Ei8_Z|'#ҟ5̉:%Sб]AR3*!;I-N9yTLǣp;u90!,Uj膎aF0O0)Bhl>ʾ#8\ƵM@ޚ?V֒ULi20,.UΔu |Xb\%vǨי9p#l@ݎg**Bv;u7%@,y2`?!VۻYO Vb:h ;lk?E?K!nd5,[a pco߻M󐖒MП}^?yE :P@(P&s~ 2I d"xt]1N! Ck{/,q#>o݈4/֥ٲk%ydQg햿.G J ^6q,9` J=EvFUC&GB9xƁ-t *jB4X4F^m>P,v=vqV@ц}dq[xaiE^bq'n)-rj!b礨,x\eѼroD OObi<#5I8҂f9>d!ؖTt '?@:Cfdj2dWWz>cׁ}eسM w|(رw-ͭ ڿ7qn{o mpˤ0,ÖTi)Y)I;՝u@=7 ˚*̓+T:eòLFI<E1/YIENDB`move=1000;blend=1000;3OSU\d d UUUUUWUUUUUUUUUUUUUUUU!UUUUUUUUUUU?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUL|||| A/C ZBKURI֪jC?֤֠*B(TJij P_TTkR֪֪֠֠YP_Z mj P_HkP_CU?/Z* $H$D"D"D"DH"$H$HI I$H$H$D"D?L WWWf#IUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???3+$??-7@d*@-(@?@װ?@װ?@װ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5\/PNG  IHDRc IDATxy|Tޙɾ'@ ! ;"bĭZZk֪m}>vsåjZ7*"AvH!=.?$L;53w9LnF!@ q"L0BFa\=$#&C '{_5kyyػ;*wuWA 1g]( 0H&bHMé8y_??lsA 0vh9 86ZNaI4ׇĸ4bHOϟ~ìI7aQUɽ]0bi6df7uvFaXҒq8m '?kՏ~Ιr'5؝+vUSPTMSQ0 UUS~噄2T6TT *2Ifhd*vn1%6lN಩t4:itq>IYg2nle y"]8eR;?GDN>+CZR6j*"k2#L8vERP 2j (EPEmW30X~r),y"JNB%>!?~j?YHQE3غK&xTUlm@ \ hhhMǎok95(LƖZa0QUEQPTE2adl;>k@$}P⣓1Hng5"%͖:c\;$#`}XM4k;S#@w]Lvag,f[jؚؽ*ѕg%``4$#p(-O֗;!Q[ F/-cHn`tE7vs A$#blmDD> x 9 A  v٣z%gL(XlMXl8e;%'{dBXF'a2FlXGwf,fdʼn$ QY~ΒI &d0HFDQ"6*= EUt*dAXD1L,2^Cs5bwX8RG*e;Kּ2n2EԻ?ajo(_{USe');gys IF ]Łc۱;8v\DWo.aD4TUjoVqlv V{ !OMM 4Nx4sEdɒLG0c\V :w$򲆑Wj*frmq75Rnף(8{㓇gSrA~89s6!+Π0 xO?vGwrwp8x饗Ἷœ;o O4 Ϗ7];~\޻42݅ M~g͚5]< @kU:'/'QLrB?44TU?i+M|%e |2!Hs`u~RESUxpN۶K^{5&Nt*`5$ĦBxX=%ʈ (*|vnN)Z~04v/Q5~|3s;+R&^|i(LW^xbEp,$έ=Ol"|<W#+mBcK b[rQUUxr U*n DH*wGwq'B( y(5~v{nl'=%[aja,ſcݶ^!M(?vfM'Tz<L>Z:~̶qJh\8;,vF?mtˡ+xwٸ3D>FK=}܏N z-y֮]˼yx"|[c.\؈M,{6ZdE&'6tmv=+u:p,*ET='JgCJבtz( &/ `$u/MWpB}tZ_ua} "N]WT_0niewV^^w 7§=gEVSȊٓ:{]pkO!bWu.zé9'滏w !,zy6¬αm1>s>0Ƌ/?8\TZNbi =%ñtx wƔ\Ę}l|M?y3i|} Jrf+yK٭$MS@X[.[evn]O=u%A}<h=0p6'>}Epu|6&]dYVm|I#.GU?b=Nj .\ S.i}BOmkVr}p2ng9:@Nm[?wU[3gQBJr W}?47[z%=T4d7O$굶-%Lx.С#E !|9mT]xǢH{\{k/9f^X8SS0MM-Ovإg藖rrJ'j/OhfuoBw kMfcg?-O~QQ0k;PލVo 7*|Ͼx@F1M]/4UUlA[oo[녹]t1Uݥ80 I7mVnxA^0#~sp<`w~*q<¼y磍]0>BoqvW;NَiembёycH(H9^?UY/éG~|oʊfp5=^O:׊mfӦ a`% rg%5b&Xf.|G/^̫;KVʽVCCqI3YfQ f<W\2nAVz |me;4Wl."}ޠ?Vm\ͮl[.J^X|oaMˊ;؝=|o5~D@.$l޵ ٍ^M>W`u_>O@K~k^_0csZ-f=(t;*r ݰ<pjCi"#+2DVElٵ"җvbb7 χϚ5kسg~'Ĕ?zCr.]SO=嗷 AϿ} Q5fNLƥ kkP^=v\_õrdgqc|H6'Ϥ.c焪]<|w2c eyy>}ɠWTTDYY?.E%}3+H$WJ&8(W ^p]K%!IF*n iFi4_3~ eee\qE&uu2:3G~speռ={6;v //dvl9%'ӄTv h|#{xwxGyG:_vz!E}]<ۻt ǤRV4.896mW/"%n駟 IUUU8p|4\Kķ#M񳸋b; Yq0x'b~rkaA/g>s<'Nd͚O =zZ=G(Cy[5k4*= q]񸤶m޲k_ʡQA@V."h[cJ.M I4꺨?NTqUr`+WG@}s :Aٜ:qfcs> ;%҉* ٰ뛜~(uFqN U>,y~a.]z#///hiYc#]3~%ڝVjӆinO)iy$#[Ҹ(>ส`2(籨jJ<ӈEtRʠ|ua+Mv.grbwZ=qgΔ; zH#IHcn=ȧ0o,?8q88v0`.S@7~+-L~_㏟{̚5{B:xyAx|OvBl^9e;K׼ѥyǧ{npyT?2-]1k]_e@≙Ur!222~˖- O´چc4kȽHiWY]BK59laJUVj*z뭠sL:/7DbL,I~. DNH/-8VLhCӜ `N"Cg$;mbz2׶?_ 'PPPs=ס>c\=Ì8HS qI$ĦϾ|U`G}믿wyj -za6A<8u=kOL!$ sO?4ׯwk3uTV\٦EnlmڀaAQ(>0%@JB}N)y{2w\=gp m&|dswG/k[fk_Tm5MH5̜{+K5GH7n/?@2Z,f_pk7ӁGOzj}/P)eW`\Ǜo}A7};g驹M*F|L Y}k`h9U$u$^8~nPԿLιz]W:r$]n6oŔpP0H&Jfs=fk#*mp^e%o&e,oO?ylOP]wfK}-EA$MdD hh}ESpީ8\Iq*Efk:aAW>^x*3 esO0lDQlY:$6r60$ww?x.mug;ةm vRφѽyh;{ｗgyRXy$b) uz}SA77i.;ۦ ׫m 4h4 hKh6A]A| p\GQ6?M4 ?)=J?k $d L'2DzyD_ nv UL.b $)) Q;W'~+~?iC!?{6ѶuΫ}*IC4I4jkwDiga]QMSXߙwhsUzqkONtz****ضm\ZG;>h"ѣGϑ#G=;gŲuΫFV|g+IzMS]ZX`"Ҥ œhSq~mN}M]*_P#E'l#6: d$2"!ua"$IYzgOԝwSIDATϹAQ3*k3{|c+#zMѣGaCǹEiBDs!#8&COb!!$D=S 6qcğ;扲e ECsѤX #ͧPFj= [ jE_v-WZR V59K[3 BpYn0jhkE&ϕUSIMhkXSv ?>$%9>4ADBy KyJg EyhM+ϜعiaAbm (@SX$I7Q(x rFd#ɬ(6*Q4ewݙFX%Jwmt^bAp+ W,Ȋ#(cRS7aGTYEzj.) @ $(:2WC%;8(~uѤ|b4ݶ1%垼ג g4eCfEv|F"bc8U{5u,yADb|Ryys(,LOE^藧۞9 05u %PQ.? r էO 5!%ѓ{9f?j[>i󝽸Ћ<꧶ UqN;9 ZV6b޷7C"A呭\0TUaH@;c:%Р#}cٺÅVNF1G^ƁcߓClZ&ָ~>9gT|K-zK.f:}>ٵﳍl$Hj}N'G^Skӿ/ӽW"&*5UM!T\~W]X!Gı%zIghTYqٮ9B+"1.- z-yn,ͻݷQYqPydki]Y UM,3Fo Rzj. J `"M}&^=IcR\:hp8ӽ:]#4T|mRx4wVӞ$`o 0FշZ (&7HS 5 Gi8nހqx,wܕ7Hnh" 0ApѤ A*9k*;m?p} H˛dz5yF$9/b}d# $gM :Z:$9Td#FSەyYLDfA Z{X{z*]Ɩ]/8]GJ 2igD0#e;V{K*|GLdQ&ezZ3a%DF]|.(oq|+&^zHUJTD NNc^oKH;K'O!*z ;*ײ}~L\|QE3f| f &*EUZB"n-5JskEK#-1幄'ҞCy~<٠5AGSv`6pnuLI9iyDbzy&I2`{ı1rVs|SyLw.tu-U'@a8S7%w-[c#IFdIp w~Φlk(8Cryl?-UO.DGƃa6}鯼w.Aww_jWaQ?1FCU`bm,[SG_(J- ֟OCY ]t'o_¨!3x_?g@pvOr}(oB %e#vNhY" }/|׮S~CI"*"IAxs](UCtLV[s8`L Clt"QD3{ODlOhow㒧xD Mkct sO@$}cl'>&)xcIdD$z\$ǧa sb _FLTvӛQ31E9-4p Gڌ%22>$'s_ӓzAu# h"!. Yqf sF/BQ N 4DM&c$V{ Kfէe=lw;h>\tONh()qi/~xzuc=~8]Q (&1}IN{u\"U?QGB3ѮG"| L. Aܿ :J'!JN6Zjϕi`䚙)*zT.ENF1/sOMIA.TTUO2W> \;(ɟ᪯eRɉ +"#-\>"bУ'2"!6˭$H2ypp|K7tڿ^M&2"Yqb؛inD=x|(bI =JIo[㎒?l׿e (SvjTUKGTڌD]'P`sXiœ)w0=Kр ؝֞FOuu.6Օ 4Vm\͗<hI4"Z/r''YHSLP>]š;%)!Q$# `wzr"PI#.wE86ʍ{̎ʵDp\"M,EW6ߢiz0Mf'g;Y-8I y%{Z/EFC>I}ڃm-}ſ]TTUHt1#QTAd ! Կaҫt\Ġ,]pGW>z]?{ڤom4 J " eQfΔ;Qku7ZA z ?5s$#nIENDB`move=1000;blend=1000;3OSUId d ꪯUUU_UUUUUUWUU_UUUUUUUUUUUUUUUPUUUUUUUUUUU?L| A/CZBUVT5ԇoR¥T?ABT*UC*jO m/A*UCRTCZJBZ֩UTCUj P_oP_/AԆ/Z5/!jAj $D"D"D"DH"$H$H$D@H"$H$H$D"L W#?yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???$??`?7@?O?O?O??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 63PNG  IHDRc IDATxy\e=t{CI @H# AxAAgF3: 3㠨. $U]r㜪NWuwuWҁINUn |1grdي,[Y t{5S,IHLƱ݀]Bns ýBGUj||ǞG-1|X})QJ)'aHresd^i &Gȏ ݀!tr\y$ fR`eMF^:Aڹ4]?ν躎 I`X9в"O nGŰhng!i/]dɂ,HC$8WpIjӢy tc\֭)XLj ^1$$^^>֟8m;VYzk6I$Ă I#^$IBBF$ =xe'EN 6Vs,Giu"IdAe,޾64M%FI(q5%mNYRXbsx^#̆&Щ )HԉC)xh)$% mPQjaw!t^I}UKbnw)?'^ vo__I] !t\0¼;FBmT%$ MS+Q4M9iX;h<%pܜhrR>-{t4EH,TOeWG;s%UD &\>X;FIa 5)/D^ y RZT.᫸^' FUE VBO)H_[ޏJ4]'Q8.dOXy$P!e?#1?N݃H(p@C\,XT֝zO4US6yq޾X"L<%Mݫ.oSұx"oXbw~'> O ɉqrJ4uqUe TB"Q?g=}8}+6. O |0x_:5A$ E%ԭtPԏwX"L"uyRH.W͠{ %J$$VW:Z;P"^BQ=V5Χ/Z Ci֝uӘ+p7W ]abȆc]+4M#B`^y @]o(.(Gz\:&ȓc]{d3>z4[ϤXVN7oQ *JnՆý۴s~2/O8vC.ޞsWSUQC ͎Bi@PZT3fgDQAUe X-v"`޾6j5M׎^= ^Eyq-$#I2OC?g54Tϡ_onxI=vtxV/W!}w)6ÃYU,[xs*Bœ{H5Is0O(1Jlv+o'ҾwD&}%}!t:{PUHܴ8Yj4MOTİox ]8Ҷ[ INDrqĒy={?IG;FFx"/>~"|.4:fZ: ]Z"i mi9DUY#:zPS9˻@eiZe7ziEAQH4uo[XɢstyKQĀthV3tIZpDğٍ+t]Wc=g| ?Ŗnh$-][xG6ܶ;5fCEd6.G!.݃@Qy&<9`__s]|c")a(zke~ m]EBJ% _+%uD.\7 .C MN]8hdĘ Oõ;o @KaF"g K:<*D36Kbw#.ƍ馛-2^Ia~? Ν;ūٺuW?sw߀g{g?1Yg%{#y\:_vŝw)-?~nme˖[|_( ZFOxHHB-Xl|a~y7mڔ"w-\Q!vYhQNe~Lqy&3駟w^Nyħ?4Vʩܡ@t{NG9ի>_˗/K,U{gv{Nc4C?lrgMsn|o[}6ax755? 5oGi*`9gv k &3 rݫv70׾f8ٴiSl- ?ái'߇v3Nǒ%K2e \rI,IȲƍٴi۴'UC>>P71aI8 m.b/_N("񳟝ذci4!4|Nl#mw 0Q]`ynj&su0j&3Aap8!\sTWLETZ9NC\$I9n an4'5MS痮y #qz ^}-ba8e'ȓ S+j{|>3և ESh[v>lmxtZF&İu.s:J,sޫn'6<衇ػw/?яYn?M3f|^O k~sq%^G&vg1%U#֜ d}|Sgt:y7'{3K;:׬YÝwɵxrz %L,qETPV\7FNqW>߁xrʳdd|y_~kg1-{^(S&-Ms׉UK)ﴺEb 7Ͻ}Dy&#Uy ?̙44i#׿u{}G E{4%'v GL;U͛ψҖyhnX ?mRI׌9==!{{lD{lfS))]$s,2yS|{#iDںRZ!llD xV]]uns dY7;̚nW5SY3A?7)ёw.o9U3ūf4%qGkgx[\-y?At\⡓𞳧,g[Ssnn0W t;[HXLay'xW7ysf!hp;Pr[J!3]K.dقEμ;}.|3>u뮻,#1)o_3_c "o"saڵ8aN$MeGOi89`l+@yWm#fy[ܻw/Nۇ{_6F[!J\=3*OaNVAgϑxo4]Grزۜج)t9۹E/9˘ tu! >s7rʫꪱSܮDr4H$#q2lFfPd$@M988x= <PRPs=U$ @2EyeRuD @P)_np(-jEkgαS P[WX0kۑȮX\ K5\3z˖-⋬X¸ӟO'[w·7JH&5ƔĜ)+xA&kH.s \ Ȓ$q% *%D"N\xٛV"Wa$LoFɚ]u^zн={pqF,w+b'vmȩ\ߕ$s/dϡwR=ūnɱՙc#M#KS[Al*ܝP%q0 , UK2_䭖̈tuuIaA Lн|~P /ш>+--8ŕa6))OI*ԯ_S,6RPR(wp вrƼXdcjm _:ξHnz Dy끜v$@ԓ /**ʏIM_p[dF7{?^dW'#;I$!Flx:>vKjg/صb`8ۜ,'ES[1F =e8n:u SKBɓ'ǟ!q{l3=+WC\.5zw@[,\Sr5׌Z|\.n^]}Gk6Q?ي))M42꺎G4e vQZTMMT:-S.xT?ҶI ʊ'5w~Rc2kBO-1$$Sf?l݁)]qi?<'? P{̚5oyP|nWzX r=wh J)u 4N$dHH9N^:(-бL[ޞi>Ʀyf5A} +y#,76?ГaddݨjCQ$jJjIZ\Pž#Y|96loqZ^ ^:^sE1yd@F2%QZTͤzB-_5L)_󼖙Eְdyz݋`[]l$$k^)-A$- EimՌr[5w`ؐdKBppōH FOc5hL"E8s|͛8w34퍗-3 5rgK_?P8H6d:>L+|P%"eS/K(HpaV̙ kI/ЁCv4w=m] vD\2 gl )8_gio7"u]||yꌄI!a_<#̔y4finSg8TTT_$i';/E`gwhMՎbb  K,ѓvϿߩǂˠw2K2xk/?Y pP.nsbYX6~?Ңj$c4 X{Q5kd$I@XB;qJ? 8-ĩZ,[%#,Yo 㲘 uZ :dtYSLU%tyю}{\HHBGQs|=rKpr9_t2V$),!NAHkD$%j*k`jBf0Df{EیX<ʁmĕ(t!KTA/G10TP\P !qx!H;>7B$O]c#ٍ5Ngo3Q5#m(pR)]f h)hIiCxÀ\hhUY2._HD}V/$on{|@9yL U$Jr2zSAg旈C=T JDgޯԅF H8"jj \Bz(+t{i sي3Gf0Ya?d~ sTcn7Y1(1$Ii=. %JBQ._iAKI)Ti4MAQ>p9 ƃN]f*P>|3%-4M1Lvyxq ֝ɣ#+%%ɓuGiQ5B`Kn~mくD@Zj ᣩlgYDBaaN= ];ye(ER0a)`RZ2(XP.4܅łbcUҟJǧ1UHVc%TD t@HyU`pB??4m5j*CLrq铜0' #!P&°KTH79U'DBM+6HI_k܍IȾFLivqIڎi%HǁWX|ϡ ~xە*g&*~!$$i`ؓ*+@!@JL,u9B>? N '-7PWGfuŚ;ۜ<ڸۮ-++LSDJ7$!u@:@0b*zۏI˵q# _;IY#,.]}Hn= --q@k_zb"[ nw[d+_eTMXMX-6}̂)l~9$nG$vPxyRObm+95)t`:||Lw&-|kF@86CäyȒ_+GI\&"Փܾ`K8}z HL] Zܶ\Q)4jAoo/[gH&: S$2&]Cb0ݎNiaՀɱnvs?s[I fYI Vga_ 2$`ب(˰VЍ:l>$$1~)g-G6o޾c^-Ngj0&­vڀgj@>,хNB.t6' f3Haד#&@wZs/# #Lr9mbA;cfcgλ!İ|!)t.n՞A Tq/ۈ(f YN-pȲ Ip$hV]"xX"L4N`ܘ)d̖C;8Ժx!I2>lN[Ķ}r Gv {QT 嚮'{&Cgj|'Ms~ =[R&[Z8v ˒ ~9arm;~)30~q9H)'IIL[d8M?zKš p\I R=G2C3,̆ee >86fa3݋w"q甯rՁW<+du IbV6}8ĕ(9|FUO z愴c@/*I`Kg$Pn=<;fc۱ ˇ|yz@hJ_](|:C'exUQ3rڰ+ab~TMeyo˘%F4U1'VCob %^BQO0;FK^u ޶ aq8v :uQ]s6/J#о,}3x7ҳ# kJ;a8T7P=>YC}nn/ {)-p0 ;(fE~Y6qCz;VIENDB`move=1000;blend=1000;3OSUPd d UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW?L| A/CZBUVT5ԇoRAUI!/j֭֠uCU?PC*Z[* P_!Aj ֩ j RTJ!jUW/Z HT/TH$H$D"D"D"DH"$HII"D"DH"$H$HL WWf#?:yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???xp$??v.9@`=@k;@?5Ҳ?5Ҳ?5Ҳ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7&PNG  IHDRc IDATxwř7U`%,$K"(6;6ܝǯl8|‹q LF"(giywRwWTw&jgo?ӡf7OU= 6LBH)4]  VMs yoǟ-P^\?4ڛ>q9La`YjRi ("?Xc˻dٜKxLJ|FS\j+&_U^\@_'(&TME4iXD* iMÊb13z*Ͳ %4$pwYm]G(/Cx$)$y></RJ[/(?g4TOW;%Leb !LEO}m(H$#P 55E=TR]|߈>ZTԁuR)/#C8 a&ttMWUH"eb u,EOcnjK(҅#I)>i/_7Υ :6?/(Bݖ@vd8y% JibY&Ҳʒne陟DJ+:O_׶=i s0(8pYO#%1#<%Z;Q^\׏<;:# My&b 4naݓVqAyB4Mݜ,QIZ !/P;iuYY ÌaY^v™kqz^hNO%wfkRJ01y (o~ܠu 11#B8M̈5BDckBO%~S<ڠ;j t[udlwuP8MZidϡw;c%RHP-w[v ŅiaQ 3JOPHphAJIGQ@eiK(\9nM8r|7kϔE>_ 8f'BiQuqq5K MָeB;F7IopT)$RN hL8I53~mS@]լES]%,wk"L'QIQ_VT00-È$$fF0Lc 3&/´L‘.z,ݖ%4BX`Ŵ /GRM untvPRXE{QJt1(e`1:omdۮ}즏!/yŃzS\XIПy8ڶm(x1P0PJ'-x 䠤r\5;DmI%:"Zժ[}ԯس߽Y+ytMGJIM$ }@@ $Xoyv/@\ZSNwfgŢxo_ʲ&O8vSɵB0@ƐI'o;8}rkSZXCOݖtׂi (=yG_[Ef&MMIaoi2^O+d_ ?x_0.'^PZG.j+1 ؖ3J!U3GT7r}?eU lx@qwPīlFHUV&xJ0H'< yR'-fvRW(7Gmތ$&+I *H*bf# #ȳl2^|Qyihh  QWWGII @pېe!>Z^o1m3\,;%,=m^8]Q]>!,*#nCFyyo:+уc$`Ѿ0NEd,iRC[;Q4O^ācXیpO#8a2{_V 1'Όg1cY4O^̴c7syWٱcGs^l;:0E̶1*mG4]U֎C.q|5$ v,]qgynF<9~'Vw}Tꫧ1o* ^ݧ^OZȴ[ظq#S*E]SiZ`/*Ю]ĉ{,g )K&.t]EsxxC,:R vCݗ!l02c̓DuuijUôbv %?uE׳pBQYZ%,,QkRl] /?)---ܹ3-&ә1y=h@J#{,2tx&fI ?y/^7sHDWOL䪫Vw^Qr~Iokhlb/_οCKj,5PٓG+V0{l.BN6lHOiLm/FkaLqKU$GRkeEyvW_:ׯ| Xb[I  g_+x3X|9'N[ ²g7ְhv^0jVٳ}_F~ꫧ1n6Ҏ~Ԃ7Lc%*"*)t"|ʊj@2ce''g߽ɳ_N|_oܬ~MR[xm,\4)3JУVQ; E 5^|Erva_UqSŽɯÀep99T tۯg/-Q'Ԏ% OooIyΔ)LR2UB>ݱǑH^ziᮤxdp(eY׷Wrڛےcd 3'+gqpe꺦,N [U֠Dutdf̶~i ^s2Lbܹ"%*!퍓O7EC_eOؘL4Ô8M sH ˙TvMx4H*:RUq D>e<Q#L'E8JO\2/R%?>=,zӌa1ۿ<4R fUֻz wҁXט?"/O4y8;oP"5)utM|O틦 {Œ%Gű}"eŰD 2,S)58ZMoq믾M>H-JqqF.2֭[ǫʦMu^Qni:ThWb teGf vgʷzǯ ;yᅝtv׳}hO>$O>$U=[\ŧLePdYnIdAu$sȓ"w.\v/V͠#3ie&yl>p^!Þ<5®醐HYM|Va`xٸz~517tp\O(k*&K=T˵$+3<#޺ J\ ,ww}7,w66~i/>:xꩧ;F|_:}b1S0$a\Y)ytt^ye_=sz+i/ƽ9a| $v,3(V4I9 "+maAl޼s玩Xa c .>7/fr} 53]/?z*.byw{o+o ʂRYRT%K+7$HeJ.mx-".]*9as+RΒׯpu׹ZSky:A ߯o_9'?9裏rC$pCA/~_A_q"#yIxڵk?,:KdyI뮻dyIdFY^R+g7-l(gNY";@ΛZ.{omx8>o7(ŲJʲ(ֶ:uYv~K. %m%؊#u:%]mTpZ?ƽ5\3v?3#H E.Zo5>KX{l;?GzW'ߴQU'-E5,u>/4wވ%RnJ 3 +i1)?c5ut -,a2:3V^\%-eׯ 65!>oе~͑ƙAXbKKԵ[x1[l9A- 5|A$P^\g_p: .-WZT%ు|^;.2-.6E$ݽmH)Q)VaFNe{z~YE_jg޼iIaK ]sAMPn*v*R ~%-7C)zig1%P֐رnu(uF+`ׁwiH0j->uX>w#X=OWokB I$BXn{ YCGyؗ/yX7oKC*קd7UZ#j6ittZ߅)Q_3~RHjV]>} $$ZmڀS cm݇qtPՄSR'\y%f{ BX.HiQ0`ߑm57kkp"lr Jf^>zP8Ղ+L'fyM` ;17Ν7uZvRWyw¤YdB4 %v!13*a"4Ohρ\?˲2h*݈j81<*̩'6M&aa) !% R 3FiOQiH xԤƉlG-̞=otH{ |Q3#v`(#)}p%3%$ `"XRڶcCuLdPHee>bJ͎8%; A{W7bwFȣhJ2k'n㠵W^M(4BK~*Jِ%i [IuOU8SfSh DOLճ/L_~Wۘ? ]V~f@ G{F"  =3P!y@ݡvt.J)BfEДW#lūt!`xN63xᅝ~֭;ը%7aVlgnrsG܀yzu3_<2~* ,]:*^lyk4%?x7eL#O)#ֶrȓCȑ'#O)#GRF<9yrH92r!eȓCJ/Α'ß_dH)ϐyrH RyrHRB<9 aY90rBݐ*TX%a)"'yrH92r!e?JL+b5CIENDB`move=1000;blend=1000;3OSUTd d UUꪪUUUUU_*'L|  JT?!(TO*PjI?ЩUTJZjO/j?֤5֗֠֗RծHZ֪ZP_ZZeAj ֤5/A!A֩UT֠j P_("$H$H$D"D"D"DH"$$D"D"DH"$HL WWpWWf# F?Uyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???,$$??@8@A@N8@?v?v?v??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8Y PNG  IHDRc IDATxy|Uչ{s2O$@$yPPR)-b}[ޏZ}~Z{KNtZj3,;(j,#)E'>.ԤaLȝIbB*# -.bDLȝi~V":hHJ7rU {@Q@Dι Ex$=5EUR`A.\WwǎAXl4aҪf:`䫭N.ۉ=$pEAJEQb_i9hZa=΃oGHCF͔S+Y89b;*{"R $珝G"U nCAq.!.>#qh)*dveezګGK"rGJ"znh/\ש6q ɉi`Ϟvbai#fCŃbD!'3)E|vDOMGFj6A78^;Ŋ9T@{e($5"sBl67Z4Ճ'x16Mΐt9{X)44W1)$ޛ(m2TLA@Л$aci(';c GJvY1')CZ<7źLuv @BVF.Jw1gII6B~W8RT @V(PM֣SziٓBAAJA(h?Qk5?y4([{njx&-IE!⫏v.**kpjvR&=Օ̟v!h7qtgtђ:UUmt%!)Q̴뷦5N>ϔ  ]dEu<Kc˙NihFS54Ճy5SZy(6ēy]tzi4ŃyPU9 x`tKބW'O|\^k.R.$IIkUͫDN]HI騊ĀxTUãzЍ0'tbCa0JHAZPUqV ԒPOrb:Y}*oE؃Ú'-y/8EuƆ& h5PTərJ+[b:QORBq ,JS{1NJ a]@8DCs55 TוPUWB0/4ET*M4׊0!=!t != )A3Nh_D؃FTShj0G]RV,*L>;n&qfH$) g0t{?,7TWUTqxYUjj}_\MP+CzM0n&P`&>Ep|kKZGw\*Uj*w|X^P$Ŧ]Hj^4t@bjNg/!ŧsOrM9)jv1ٓINL(E|\qD1@ȇ?h;mFERYs6}gYaʫ0fdԗ3|<`ڵ̟݇ߐDϣ%#$L4E蘣^@6tpB kf 3FwN8GxN?De˝FZJ6Bơ.BTQp%#2:/Vt=nЍ0s;H:/'C,q}[:)kLb RM4Rp}lc'{7^@TjAA5bx@C>BaDIM ?30>Mt+:Ǻ}kCJn &׎ݺb_64KG⽉x4/BzޑP0t> Kfh6e@AXo_5K8)˜/7-us|\EJ\d.zBJUփAa#Ax_Fz>̲y8)9}:Y?:}8aRP|zr̨'!.t&/~,s?_<3`B:0tPU[̩.EQ-甦I;Sn]1DCR0ACSujUӕ=GCH[=hʭך"^@?vKfa5x(8((i/p|7#YSG oꀩa,фэ0B4P EQ(:̩cBv)[V<4fgDŽC; u44Wc[tK+9^FGeOdRsԞsܼgVx&gl/GUmv|zCHk^U=H)QD$?}opBsդb{gUIM"Akxᅻhiy ]gwE|.j,3m5ET*Gf| [@P8`6(l-Q]7[Q0T&i^ ]gٳ&ݜhjk S96@Um~m y953E>75\eHù,zS?0-B ғhlG"&{l7c紻e3~ s_ĩVAMi}CTaX r-3}V ӿi-AJ*[Grt,Ɔfh "昫3R KG3:җ!X;Jtt)mK:MQ5vH߫?\km۶ 6D/̖Gϖ1]pL>7MiiW%FaH-D!=kgǎRRq/#}aa5j5L^#<:\_f|c7rƍrkuMX|{2wܵkܳgO?A>^nyhذ~ đs9+ͤI䷿n:k׮oȧ~Zrrޔr咯k/[/YOҮ]Vꫲ(%% P_$$u}yAAϗwy~XI~ ;~%%rkm-gy&`1a~:mg]-'N_efT|gW?Y5kSL]w7{ɟފ;"]) N9om7CȦfI'|t|H6[Tuh"|>{g9iH8U}19@I8[nEJɾ aD8 Rƴ%api);v CE_tDze9r$/";zΐ*ӽLXly>q8.ml?Hhճj*/^-ѣ0ϝv-BPQ{ȂѹB_THdl| Bgz{Ǎ7|tDǝʹHIn<et #dΝlذ?O'K?pv({TچS},G?7S\چ^0ƏoĮzU:x>;bR<7O}C;w_ʱ8\+z9Osl f :!tNﵚ݊=iY|v=nŶ}:}~m79E|%~ģטkmZ23>?g*wu|)Ч-m°DM=UҒ 4֚v gV&կ 4#C~'l@I;ϧ?ngf}ܡ'eoM!~Ջ\uU1t*EsTS, $z#D.ORRp̴jZHO!ģ<Ĝx9D f,-G:8mXعh4K(#ēi>$K(fH]9NE1y~ bډ$i>FH5ڍ)|!)Cii)XJRMEWR nB=<10;߉'NjOv7%m+wwĜx^>GVs㍳ ul~sضmG' jӒZ ;R`i*vpI##7 wh']s nyf9E~~6}V6hϬ036D?Ja6Yi'MNf fXn(jFSc;tyg ogӏpcILx&·ŎnB"i(GU4G@69Yyz;ҩ+rA46Wc*0K+̶mwj'СJfΜK8<ԟ^ no ˖uE5Ɯ«oU+"l uԕusJbako>ي΅D:}HO~2$5G}m ӝpl؜EdKu]) ټX=K#Pѐ]Ni~l ~>鹭.3#vdӦMYGF%kmn&'i-B ̝əB7Zar&ѼfRtʩĴxҥKyGXzuee?ֺ޷3^;FsMvjR&qx+h7G j_'Z⊧oqld9͜YRoPӘn 4/w#JLvclܸMzwrϱ{wxh+,1}ߌ?ZGs[-m5s$fԄ4xN1Pҏ{ሔ0/"YYYηi)Gi?)SsB46( 5yW<}`Æ 9u=c.PDf # :6NBx/[ԁaz rp_^^u@}_o_r4|p~kl{[[o2 y\"5D+q1x\"KĸqW<.%b\D+q1x\"KĸqW<.%b\D+q1x\"KĸqW<.%b\D+q1x\"KĸqW<.%b\D+q1x\":ɤIDATKĸqW<..2IYjIENDB`move=1000;blend=1000;3OSUEd d UUUUUUUUUUUUUUUUUUUUUAUUUUUUUUUUUL| A/CZBUV* *UB?![ԟP_CRHkk/Aj /Z5/]jUOT?P֠ʂHkkP_ZCZR֪A֠YPQ"DH"$H$H$D"D"D"DHI$ $"D"D"DH"'L WWfW#GUAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???wo$??p @n7@E@?o?o?o??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9;PNG  IHDRc IDATxw|Ugܕ vaFQQ{tiǷ߶v؟vVC[nn@T6 qIn QK{Ϲu?=^o0##?yYhnh΁[NAL0M LLӤp8Vo~S.44(EfZ " "ExÿSD~HR2xwSm[*>Gт̛q= 4 L*vS]WNzJ?@Gs4p9>nn}W- "u't1L4Ѝpu8Bp SgJ|m[ŀaLӈK'(GncbzJϸ0 A d *m(BLAtܩ8dg[܇+ZI%8CpΔ躆5XYqy{0 0ⒾHI0 cՇ0 k 2ML=G6`U즲Pm`/UZ]u C,;EUꛭ? F͒ˋbxdA@D{- ")"&ysJ.%'MW# ĝt]E7NO[G!2`cd#ȓ጑_Z SE "S(J(ֳ`(eܰ3qx;ԏeo8[~P sJ.nhٌ0."9ɋ j(0ʵOѩg`PϣdKO eR%K+xֳC 9Q{/ ]E7l|8KzJ?sGj "I2&T?~#,kȡ#^^v!=hک&"ao9cU\/XЊ<" E,IذcE/қ$[.G^G)WO)MP _þMfDyTMEZ"'c j!tCG5|G DlF'͎4y* QjԐ7FtC5m[I =GP\8AZ8"o{u Q[/} os!4kq:)URY`9 ;HE5{i;JNWւ>3?# 0dXuHy3n8e*~TMA`ס5)p1L~K Q, MzWڴ+& "I1g'|ȓ͊{+躊(z5]{i^qQ)`#Ɂfj,5 Ckyv\cE :[?6A4M¯΂[0 䴾Oс(TՕ!$\$JȢah4<7_|C ¾lz[Zk*u]"v8!t]CL[m؉ ˟HHsR(KمCSe7&"ܩWsߎmL}f kt!!';qȶcNr4O}SBǗc gZNJ]E$6[?l{9wuq[p捔NI#Q#~5y,&-|u@Mp8PKɆhڇשΉ儢, tT!{W!y|!E1/3L͚ZD vJ Iu^*#&}~E QU5Ettq:8.dYf;ӥ2ZkOs13Pm-WCT 7 ?FՕHDe@A<6$odVor9#6A|h~o8yمeXk-dUU1 ˅`Z^Qo?e2`,w= Y@H K$MF$6^IA1 7c;4Izu04MPN\3LDl{M/x *B@}1E FPB@AŇ8 {LV?ix\^Ҽ9;J c W D̽ ~ t@4=8nZ.%l&vCHib{t# %]8?y wdcC-c{#9X>4YqcҼaCja!%/+1ޖ/ ͸!4M0 UWp _"4<|v]UhD_=}6ލP]S$Ivȫ6~y~aE $6$CQ-^@ͼ#wFr CwS8gm"e>;21N݅)(j*&&ȢZUL/4x앟齄aZI,ަȂi6݌}s]ô )v, `؃nx^2Rrڒ%]{5zȺ* B4#րp2LEs&u Ԟ*NV{\y~lo&jĒGQC(j8mQ;:4]fN{+)! 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[7li8mitE5LR$IS!yd5+Fqδkz"u\NRTE#IY<[?™Aea\NNv:˙(=kM-jM_غАcʨ(tx(W;5%ÜHh4]%`{N 4pxV`IfO^Jea.#F:@jr({ݯֲ{/ 0|W=z x;>c;cƵI9-yyŬ"~T5a蘘vjBUީ$l_K_vrO*}a.hNf_'[^&^B;iDZ:T7xEOH^^5p?xW|Pȏ躁Y;wgi S9ۙ$9N ;zg!O D@io7&=w H>~-d@vQ 5Ohha5{ޤwgl~oo҄z3!T a?&O./xkHNvsozoɒ \و HvY֩-a&1x9oM撹؋~%c޸ ~ܳŋJ]}g=fR|{?ƍw_>ټ=΢E̗^)ʭ&SpE35$O~|zo/s0HecW)+e޼1Jjs,_+oh@$}v=MQxw[Xhs)IIÇ;F¹S"\x2Ȓ?~sɀ"N֕&R`7HЬ)i>Gn)HNPԡ)y0-/?NoC@b w{$'wzZAi$yR3 #\\``CmV׃ STc gZ  `pyb2K'y街Yr799^}Soǜ(;FH[bj2zYVeO" lI|LƍȢEO y.mk(` <~1X /{q\*+쉮b̛0M$OZЋx–=6TPPAfZ̺̕_?d`G[?^6M|t^gizsb_¢BirMçt4sQV-Stp9=݅?|NzzAg䥜9(Hv,;%'e{nZit6mys?0̨g!9rzɄsCn*$J9$Qk<;Nki+]qᙷZ;, QzP24>?蕑'ٓ8d'(ZexUOo+1LQC5-=#%uѠd+ y}%I m&/D%[ Sry"}]Dy-nhHb C 7  +ƩGGBڬVAdt5&vBizeup-@=rwr`@G0D0KHu9jNJF[?ESG9S[2ɓ>/4&u]nkڸʚhzbFk_Ku]9Bv5XL䛝FbЫ<}Svl¨3o 4#" Շ/q]t_dMԶa# JId7~ENP X1M쌁TZ>+qnR2F.ppi&NY/ );lLS@5- )F|z4]A7/ Gܺ>DQ4A+e7؀+h J&gq Iyˡګ9d LC74UApq i!!ZAUpHX\.RiRU[FMC@65;(IA^1r45(HM1LFi{„qݢI؉}UjW:|_a 9>_B]|[WZrw1 _?콽KpՂES{WuI~8.IV/8dkh K藙 FS]}/<./@g*}Ap^Ț璳ktr @:=/q"N@㜨-P)Ŵq 7|6`fXɘǕޕbDz$,"\A_T"эGT~wS]Wa < 4YcVibpDs k% fOC9Y{NTN)Zd\zG6;|9ӮhnV%D=!ySsѭ>A3,9;/̖=0M[uvnh\}O+$ڡr ,MNCȢJku-{>@UN#1t˺龂̯[ 6|tݎ 5RwࢳN$j5D V8d7.Z+h쪢_6膆)wYr@ܛuE ZOtCG/.y"#,9EGd[2pJ`;eľ#1tI 2IT-n;J`M[E$䅍b]WO'B7T=#LCggȒE H@i=>~ia @/IENDB`move=1000;blend=1000;3OSUJd d UUUW꪿UUUUUUUUUUUUUUUUUUTUUUUUUUUUU_??aUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUL| A/CZBUVT5RR'PԟR¥VRP/*ORB/Z5/]jUOT?P֠ʂHkkP_ZCZR֪A֠YPQ"DH"$H$H$D"D"D"DHI$ $"D"D"DH"'L WWf#gꪪyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???A9$??@bp:@@*@@3@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10l&PNG  IHDRc IDATxw|\ՙNoͲeIe[{ƅf ,I l脼,$ bjd!K[6b`-l,W:qܙQFҌA[s<9CM9+kӽ&|99**vPtuz1|Uq"Kf!p`P싿0]df y@BF$B w@dL&3c2Iw9XV!:p7`9 +E3/b$*v2mh3VVtz[&wMt3IW̘t*fYQQٸդߵ yyY%6!Od`:AKє!Obv2lV'$#!e!Ob"2@wɌ!V6Y;RVNF!L&+NI y b:mHHlzʐ'r఻$ tT!C4,ȒjK}Y)/! Ie66@Jdȓf%vJ2I3Ȓ@`p+!g y Ȳ)eeȓf>Bp< YJ͐KLv]}xH7^29X4b*\𽔔mDeFMHI! ;[BՄY<nJiӕ!p-} ɜt!v|Lfʏ CSo|y}O fLrݪ;nb&]>dKKYrqϹ{itpBTU廿 aX `ս_8|@5 E wI=,q> *(]M0dS'U~$'Of^VO{w`8?襹Gq3Wz$YFH6xƖm:@Wo'}%;Cqwzjك`^*^B4H~<7'M?6%&V,~Rvzn?BKK ?!͐gXr%ikkK}!@n[g?G? '‘ϵV9{CE]š=ج8---rkHr3qpw"I^oNee%uuuz뭜yÒ?mR*P^:o"**y /gavvv ? yt~(BKK رctwwm۶^x#q*;XΛrNiFMlEPUU(Òo&CATUSUTU ySb:(W )) ?{ .{!]\e<A-fp04'#c/q}3eoߞ5%_pxyJ,Yʕ+TY(ɯ ʦ])+7'a6ӖBh[|_66qtM{گ5y.\H[[;vuѴ?=gڵCU=n9)ɯie!S<E a6;ؒjA"tX-5ɣkX KK }w=q7}vv9ksׁr]ZRSlfu2 .P9ܤ?F:[8A(`J *)ίX^evFO3Z [hll䣏>b׮]Ѓa=L۾}у^@͸RWORQ:E RB~>{B "T"UAU~ìDS\iO#35"ϴ C&MEEv<˖-cGIQfN>rJd|% >ܶ&aYL gn((!h$Z:" E=(?[v!8ӣ?2‶׎ۙBQÄ !% J* -(HȲIo~ fhގu_g치P5}2l$ys=o&Ǟ0,f.8\O`7 v|^Ǝ$BQHԌe38yjm95оe_FnV^x0m߂_>a%ˑC8Si & @fH̘tZBx|EbaX'3o<&Nd:5S=ԅ **yZF NE 3h<`7oBpq{q~ ϢvP!ϕW^Ikk+rTU`YϯZR= ._"]H(42Fs7tdz⩵kahyvÇٽ{w˛;Ѳ>Cϟ2"]>YtBpAU0Ң l9]p#U}5KvsnwuPHdW͉KD@lzA,W>Y`P~Bq#b |n?lU T~kaR0oqs`w +_۟'>r!p%ŴA v>mtz[Q0Kg]}Ǔ'S\7{bzOA' OH"(rsl.,o4{^翧o3mΪUrM7qUW8R\ϰۊۊǕR}##}yuO/R 7D{{{5u&U⑚^uF3zlE st}c5O3\斍 $T[ǎurP+^o˫v[B2?㮻߱1PW_&n%9BQDP`Pr"(Man]ۺcR kv ޘD=1qbHot w'O̮uƸ~uW}iR_Aq~v?&헗5Ң @l7[)޵Ädg"ĐP GI@+G`J?K1(>7D͙g"^MB'4#V >o1|\ת%~ZZB亭京VdUEn m= EQxCA}g|k5>5kMP3:qHiiO{pUolEqB tI({ٲer&QowEen\@Qº{GX{Eyc$HA`IhmDjPTˣohu=\foow7HBy ,`_' 'pP6ya]rF yra%5O+O)=. qs99n5o?lo!7'?<)S,$Ii$IGx+v mGh~||F;L.Ғ<xdž XjK,'Q4 iFQ@QCѤJ!iˁ(t Y6ap;r͙KSL& {\{!T -mR]Kp~_RTTĊ+' yƏy4Qz4HEOw~Œd,ZYd )Ϳ>Ǒ ~p/沰k.JjV+{.NK.$aurT @,gPyQFgs`.V̞=7&|^_3c/[e˖QQQ<5*MeT5GXU-p߳7]#IRRw$s 70a ?яr8d7ׯ#~O|,Z9spE cS12ED{_vwPU qx(e"H[\~|l޼>ٳgS^^ΪUz\}h ZP=y1k,fΜ L:E#Z:^x /h_o904R$a>fHMm4;tJB-s1B<ҿ%}u?iH̝;>=QV2Ɋl 5a4=>~8Y\@[ \ k{ AMlB F>c< :F(UK=`h h!m}豦Kko:mHȸ9TWGBd`20f$!?@ȧӇ< ,Nߍ}1u$֮P w EU~NFOD {hQ]!9٬N$$r<12TOB <jz35lnYYdC~!?@ݾvN!k^GNE;v.Fn)26 !lL{$v,&ѽ?-جNr=E1oz bbZ_U6 ݃,>Nx}턕!Ҍ5ڱ G1C)f8w5zƸ sGvrN@ t{ii?Bgw `(`؉Q;23F$ZrQd _6=FR]GwE Awfuq"ӛ!e%1DF(>)Oy݅ Q\*}feG4Z{hj'YɤEʚŁ#NL2Ї!d8**jϡ`4nWmMlO.G6VC_y-U.dlGv%<*tvެ; d#*a)%iCņP*ڗ[V2Z67]Mtv5syqlas{p;s[]dZ ﾙ.dt_8u"V_ّZX̶^vPFOܱ8c2zvUUhl`G*᰺q98j>-ƹB㴎۝{%ڜc8k*anRk0LX-v@3+OB$=ج.}lݯ^s!6as UUḽ=WY8j/S\$0?IpbFVN{涪$ZP01xr+ )3P8ßwnG.GY<<|}NKba*KP9z*k{ UUhn?{ ̓U'hG!J{W3$1p gzY*cʄŸYx8l.$IfG{TN%B婵?O}1 !Q$Q0m߻e3 w3+w%gBiv7QW"ӯb*`dF柴Yaɂ*^V2PW;['Q:܎ È{Xn=*)V0w 32)u> /Ɍ,PB& Hq^9ٞB.F! 1F zI[ /F* #<&'GgaZGN'+`y+O)E9Aۡ*2wa3F}WI`ēGHF6i;R3"w81jCjbD "S)mG?fB]iDL9%c!~ uڒe3W{6mo3F!~đdt`89ʌI1|BL}&UvhBJ҂qy wG1Y' qK bd>,^jtT5CX {͸B^&OQڒF^V 6p8ݯ#TACkrdԹg#GN%$jdFcX y4w ϯN&ҁ9ԸyHD[gX,eaHy p 멍"U-5uē|T 8wj]ecNۓ,=_ H;&@u|lr=EX6BvB2I_EL7BV^\e:.V-F6<2:x̪>wP(tQ5vv?QCL$!OFģx,u6U(t{zC;LDDtY-@W{lrF4y,d2ذ/J_9hS18rz#B$&UE_#xܐ3"3 %T&~]>50V_obH/>|bgv IpM;}(U׌=O| e3GyNs)u|UJ+Tb!xDd,yb/,:cO _%Iһe:b\F[{ng.`7]Vh22'Q?@z}IENDB`move=1000;blend=1000;3OSUFd d ꪫUUUUUUUUUUUUUUUTUUUUUUUUUU_0UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTL| A/CZBUVT5ԇoRAU*B??֤5֗֠֗ HkP_T(B*]jUOT?P֠ʂHkkP_ZCZR֪A֠YPQ"DH"$H$H$D"D"D"DHI$ $"D"D"DH"'L WfW##Oyvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???z$?? 4@@1@@<@?Jΰ?Jΰ?Jΰ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 115PNG  IHDRc IDATxw\W=VPsVle+X’eI0`=fNj1k```1eY>3 a!y-ٖ ++{ǹV:UwUw˶~sOU=<@rcY&,i9uxc+J( S[LmUgtUCH@ *k)9zv_Fט“1Z3"l54\BCb|=_re`Z}o - D*AUMH)9Ҍ1ϛ%-Ќ;2m'g}ޢ4լB!4{|H`IKwh~d蚆g|pn"1.[{ݴ/kڈihZB`4[!%RJ,idq2x6[~oBhDcY;؆G &=nːH,P!$ /)F ]u7?6&Ux|qЬ9w`h`xKWcoEMӕ44Ms Oz3^7&tַ|\<E,N2 ]KJV/H{iRjHqjB4 XhBx5O=9Bc j]6>BljWfv{i/j {|h"{a4$a2eJ$BJ[j|\t.jYj9аA$nƉB{m^?t@i{g{su$4L+{'uv쩌Ʒ,)MdÊ25K$*X {1~?((#Ƿ,+SxgBiٱNBia5m'BiaZb* A3KhMY<#]YρLH<w[ ӌ#].TBeI#W}yQxfiz*i0c _.[ խhIVWQIs4լ`i|=qcF)%~oNFF \c**a1Ld,?%s7i^A,! ' ׼$uϑRRVTC}rڻeEf=l ba_j9OB961K UiĴ LpMe0eDk͗RY҈y3xsJ$;GP^\eYV1Ǧtv7|xrk5pwZ9 tmi C=YIq+H)fuu  GDZopᩭXΩqRU mI,N"1޾;_T;zЌ7U]B ˲08XZXtb^xs5r,cdT4PWJuy3y9X0??=5T/44dxCke IL-^-o4b||_{hcŊ  1<4̕o4pKZ9|Fo'EINwzkX0afÈ20)_ߛǻ|? pH$]nĴ,|w.0i6xC/[Uè2+JIwǥ|>i`Xk?9n&r|yXP#$Фs,md D41m_Ӟ^(xlAmG{ 2TQ @n1A?@? uۏ(X*Kd$g)u쫿{_Vy')7+&Ǘz]{/vHB;K.GZ&xU^> vaySxE iYO)EH)z|X9?-k$ w{o$,mme@^Ik "nŒRy-2<,< M)+wLYz.K+8xQ[SJ58힏"'H,9\~okό&T4aMl-,$Ҳ7vvؽfr ? 15'-)<hnJp7CM͹f{ s[ּ;eTaT gn8Eu踦 Nj%%3mI~n1Dz+,LThS54}꫖'WAv-|Q}lAHxr|>iV^ ij")%Ł ʛR7Dc*34\{X_!L nD QF ]ѽx<~Bc~; glPSYYɇ?A廙oK!Iay_<V.RXՊtG{ BVλI:u̓y>Jj(/k5{/50XN=U.eKnN!y%]}a5-? j#  tuu/? 6_“O>~o}*y޵&ʚ08 gU\_j@/plk->B }:馛p?Htl1z+?9~ty>:8zv!m:o7<}\@^1ŁJm[}Dy ̛瓞3st?q&؟GĔ.,Ƒ3/ ƩWBrYV޹֡ϱ{Gl-4^Nwv~r|6hh@^ OPP`06_0]rR8ǕW^׾69RypAK^w $+Vpnx w+ڑ4=\})Ǖ ]MJ֦d*Z>}ӹGxq2_ԭ4 =-@Ƒč(e-'IDB s^ͱ`5 E G9\Jpj>i2թթ"`V3]EʭJo{\1rbpf ?%LJ4 GCϭr`\uwi6"\NXߟ;L &>ntJ26s8dFػw/_ȶ?Ob b[~nf96>beŵw5:%iIG1խx-3Xr% <ó4/nFui?3S5@YBrc|[:x0E<1wM#9rEvn)1. 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UuOК< J8e%若*Pwg&6ߛZN\uY -ukMX67S/ 2&#FJQhS `pk\jWҢ됝 s^~n"TEhϫ?#“ެ ڼRկw a V,xW=IIa59‘+n9O4chMk; e'©ÝDjm gmdcrwTL8dLfVǣ{QMUU! 0lg`=Ԕ/iXڸ;0( yvBŅ7*Yx8w2-ZÜhR1^r zrAIa5h^Acu+ խ<6ҢjB $캬݋L'mi3Ů]K 򵯽 MӐ_0!G_U G2߃cnTvņ^h31 H-?7@ER[b?ҥx) T&jn. ,)t4!lgȚ4׮ƣdv=ˏ?~ Mo#LxHxZrG(xqAep$;Eu"LrY$kReqCCU8XVTP?l,,E tcIz,َDrkV`Y#4@J?7dl!7ht'Ɛu*"~_R "HJPI_sEuk ET4(,*KYڸvKJ:{s+f6$o>T5#-?׎<[ּ86:=?q|4WD )rVJK1F'H8 ;2N;9HFVFPd:#hnNRHFB}zUY"fv<ӌNQM<<&++³~Nji)42۸>NcdHS\m)_)ZgPvDHvZv-RӐ?,Ǿv,ˠJӱxZ{Oi,+!#!3hmLa~+Wfpm=ߛK,%UL>yŌ iJ3̈́]ò}AI֎g s͊s3z۱PwPe-="]hLh%-LS$5MKҖ&?JT[xKǟviisD"ەWaϞ'_/dt޵`dX<%QlY&8uYW\Pp4)cG+wk!/'J{SFe*JƆ6/ D㡤ikL0쥶b]a|3fsӍ<Ϧ=A4&xIʔBAoxT$؉e hks,"HJ~=;70{1ws#Ѩ;&6#KbgvaţysǴeSv i@ěRJ._o[ ϝ~[BoщC^ϛҦzf?˒R\J1]ߗG?y08eŵ$[UbaƩ,iM+qE{$|&>ZSZXM g4Q2Ki݂ eTMX޴JhQi#j,kRݢ]:w^~y,kĉ\hpN8{BQfh,LA~!Q^\.]ij48Cw<w꫖SWBIa%@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???$??wG#@@`7@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12&NPNG  IHDRc IDATxy|$Wu￷W2FhFkvwL̚'xA # @p o3xlس[꽫VUwK-BGVwU[ݧr$0n)s[)o-s6G86D`C'_uˮ)?͉7Ϧ9b8}񜷫wV08ԍKwS/fk}qbG@Ph@GOS;]a`#_Op4[PrT7RU@ws֮ccIFf,Mh_x-a$N>Nڋl =}.?.JR2fi4$18I#N2'aĩ H1)ҙyD!BCvpTnӔ-W#l9(.q"t &i$c#A"$%HirSj5]mo!Jba.N5k6Z A3qp=jHi"gC)%%3,CG<k\ϓ9m'_&4 1-.lu 3AH` ^Db&D<>yЉĆin<_!RJK#0K`7kcqmJg S߂isN"#0܋ihBG {ex^P#Tgu<9o+[~&Mv {(@JI_=ki\DkΟ㎳jo`]w.\λG,2~טd(V2iaOR/?+{TnL 1GD2,≗~D2F4Byn#DӲSy tơ*w ]QRG`ۨ/'i$Ĕ&}m#<}n O#4 "zK?םG`yN4!rʹw4g'ODc$Vp1t&TVYZ?fN}縍Htx2)ϣ <8y mഴmi`&idqˀBApA4uR41}AܺH M~Sq쩎C p??֨Ĕ0%dJDRO5ިuN6Lq4*kz>\Ҳ\n7O; cĹzy`֚]^gROFI<|<"a#Y 橵zxme hP4u'=A8:U[>6嶇G iRny J"ؚƽiZӖ[U6s1GPJg}ΝGsnBM+7pt(/f5o .(Bh,OʹoH&qhJ<(hK0'ZM +}h Mj++g5? 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B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???$??$@߯9@`=J9@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 135PNG  IHDRc IDATxwur=KM)B P FDDp^իQDWl M $M^N/31sfɞgK9gg3=Ҝ+k躆nu hj;@_9yMOg<6_T>@_ݨ_;nEq;Oa:0=D~0egx^`Pp7y hەwx=!$a^PYppk f Smێu Cbf$I K%ai#i`$J lK.c]L̠)t#F^xI5ˋz2fA0L{Z:#z@'#OD'"t3z43ɔ ]oúa|&;Bgp+mWsͽΉ'# $ =wQAj$fHD!%J*yLnvRQR;wS'$IBX! FˑA[=}(hZMOtz}Ng`R Zs@}DKf_'C$tCFqpP$_~.?xPCn 6tՠ) .u=$e˲.d@u@7>{|#Hi!1@W|2͞! b3~)~O)=Iܚ-Gz]U6HoMm{x݅I\ PTP} ITMG{B$IBSDb]!KS t¿}۴uȸjgWEE%R^}_/CSo2H曍8 w-}X7EgCqYQ -GA,dp37u ̙^<[2'!Vr$QU:) <5K~BV#%C4v[ٛu$-Fm6*.4{e!/* :q$2p jj-xB-a|r~/@tPa,~CTLFe<.?" $#hzMO)8jjZRVT`Za3Sϴ-GY6ܕu`QAE)QU:Ŕk C!1v.]_#Ae锞Dzyk-rS|:Z;(ZK.5E0 i^$ЕVN}G *sC @SL+m0Ut*J$pp)*ㆋ|1CTԃ1fBgn /8⋽ 00&LoD1t=Ќ°UQ\O_N,&$m G;1a͂５Ot,&z$) w䍞)ճbP+|o2 Is6 m mPTΠ4v6t3uhˆt~b5 Z30eOߋ)c{t!0 Oy3W,L_a Mr2kjniXG;9v2&Vscѷxǹ/s̑K~ Sk0u|f/:PU5˯&FcA"n32yȲHu~$Ea 5ytxD*foSɣj1753)[Eh"$K3$Ip0uB[ױZZ@UEzqm"nSBBUTUEQS>{L730tt!# yô4[[v^Rj x! UsXJ=bw8wPCUq88NUHm9ڼb%d L u)"BœB|^3 u Wbc}eE)ojk9Y\,t8#261HVʙqDx"6I neʄajIm58עIdI&eAԂ! :MH÷!tG~4R$ [OOGDA4s0eeM߸l_J1ѴTJ<"$KVc9T0aDPTPAU,yWgCVp9 Q3[3'$PMw ;͈$;Mt[Fm+ئ̝G IHę /cK|U 7B׬jV:l67Ik<Ͳy# ]Tšz jnv QY2N;ȊԔAYZPl͐7X,% vd2T (YMjg)cahpPtA$ӉA0#zUu*N۔x+bS%4=emom؁'i/3 |\mM ݀a !F;F6hH|d eE5 HiT5 ;Mdٴ5HjDɲMv(btsDӒYԉ̓Κ7)Bь?Ax8}$N ilzWYR,+n; az ŠJDܒ,t[-b.+:(-͆1Dc vti@4=l:dyGZ ~J ӗreӉah00І$gM"n^dׁ wܑEH'o,iYV0bnFYEB]Sl2+cEe.bZBR)T*i8N'NEV}K瑜M=#,s!9L N-/=8>*k8UCGҐ%YQ&/o_PTkY @Kih9p:6k7YUcnwg% OB6$p:\ -)Q>aI~@_76eg>Z(~{slh~NOI#=mb Ji(hƐ\=&"W=Ŋ,}I5ߴ%/_15cI+`<˲bz[a&dYFQ̘/|Gy/׾5s b ^L>ne%u4D F^?ai8v)C9Q';*3`0#yBfP(׾5,Y-WsG.&h'0#ou :یÁ|u?KϾ?oJK:Yr&H/ #k*.KW |/a}yG@ޚ++)SRXE2'OF%DcΜ)TCl $q[jjVHL믊3Lj$38(f]|ݻws7ʽs=\sMՖgwGm@i`-wiw4[M Eq8,_pa)m]hrJnʫJgg'a1x/ɀ裪4_,FhQg:;sC4$ [‘Z;*Jwx)=az:UyV P_5y@ӓ3a( Kr\I fOTŁIDk;vd[YYGD77k_{{;㢋.fk*f%$,CccA%j2Kטl&h<0L]ZE;a&&US1Xw{%^*\xNZ,#Ie20?/s^%W)zNkBoz5 &Wϣ_-UיU]]ǹ΅`~Ѩr6'H8|bGc&ϰm|=g{u OgT/. *^ɼc7bϾv.ױ?uɑl%X&WzneՍ3n1Us)+cWM} ^~%)oǸ;s x׿u#CjcAy(]m$(.e&U//H{\%D\>#˺brҋ8( L:i6[X$$aĹq#?/doɄ$Yf;}10a 0ؼ ڷ3wlj !ؤ_L$s%NFg)`:yY[qe 2{߽K\IqCh=m͡ﰯM:C-tt{VқMrJ6:::Chz\iq u(={@ g}?НW`w%$F`A_>A,& .1>|Jl#Hķ)wgSs?fF*1~ۉuY>+ʗ6jرm۶:VZ~tB.{/9Bu,໓7ы ^x7Nz&Z |Ċa -ҏ!OGh# y$oWMm8S#;wr˨)7EٳCaA/ eˠmd⋿EV>Oub֪ *p9=UkCkKc,عs'W^y%H;dIt=Xz.D3.6[: &7;ǔqBc0hȘLH&zˆ$1.>kɐHBt?ɅwmY@>!^|v#ix6LYnX !xUyƷx~k\I+yĊ2oH${í{~`T_Dv}û u Q] YQh:g[8jN1y͛Guu5xh4J"@A{9t'q|KK >z3~KLJZ^曹54*YUq:ٓ4x`_jiϳcǎ^"q$#V3WUU{ٻ8kfb.d3u:C6 d J]8 ܠ$I@/A~q-E`ڼy3/Q]"l+;{|;y0tdp;e<^=%$._<**3&/?ϝSXSG^Rc^qh#<8pduѧnaCN%bhx֒JD=mf&yEVQe~|ύo*+n-k{ڽd$S1RZБ%_|1+b;/&c89޶CV!4ѷ~2;ؐS(Zpt^k.iR]ep+k6;GԦ1/)i7 _0z_N'H@dEdC0R)-Cw&Z>Kڳ ?_s+f%Тy8x[ylF'ĉn4M''0 %f ѾOHu"Sda?uY<.J}| G7~Y q'?r:<,XX]8 }v*]`12$#TŁR`Z)ʜ+Pa=f/EgMG{'y~dY!nCg{YqK/܃f:e@B741+r4]C.sN,lӋleU3cZN,J6X̝ ^JuT¡(X>z'.뼳%{EZZZЇ>ĢE<˖ճyXe2jYqa'h,}* rz%[:IzdXɊz7Y *0ګ1y}+)S:I(LQYs>/3ꗘnd%C=F:ygytOɵJ;p mƴ5Ʀ̧@sj75VYiş6 acjBV$B` ()s?5ɬk*KHǀee|c yXLs?[7X2udI@6[Ia%s4,Iaq~:Xs׏6QckejBbbڴ2!IHª.*Od鐄$~?e qy.W-fVoOsXr ?k)?n^./H'T+ϻӃ";%MOLFY4LB了:@YWBB|>7nOMLX1 oٰpa VXMx%dxc4w3h.Ǫ)-iVIF(2SPvw,aJ!!LDSHUn„e]׳$Qؾ=[شi{.C3~o֎uc_#6{<.Cq 4&db1uݺI#4 c?H$¤I<$si]c]8 ~ \6OUg39x<oHX}Dx bƵZ5dEYQ l5O/kJ͟I'"<;<0LoyNDדh9P]6 MOv0v/f?p\)dYA2$qio|\pn(&;^Ū]/\s)fz:tC#vc{/?mt4ojrp;nNՍCuYU$YJed~֜+{HI~nTobs)қ[} dh" A2`*8wٵdr:VN]hNVj͊B;T ¡q:\f& YAd:O3ry E:xaX0l *x>xH9[{0 (D@5 gUP*# 4Sk)̥tq9^NnrR!POD( L ?Kf3FItCc[̨[^'@.(_}l+l౾O]+)N\N/w^KBw$>ܓ8)Cu"e݊<魸$٤KTOsæO华ض>Ãtp8qn oTf/(+l%3ɒC>-WJYQ ϼ::iL]h6Yml;G7Y^7Z&"F0(.]sʡ8A軴ahZ2oCX& tŐyBNN%(*Bo`US.aV8]1$ilzp+xgd磩,+$Sqv~vRz 0N HI!϶B`zFzauHfw=t=.tcXDOd\q'rJͶNFkY62bAJKXBa0Ƹxhs>F$I: 1_/@%vC:0r=CH8]TGgj!t C?d kx3K?5$N7]QN_˸l.D3Lv,aVߌ$Iiځ,>L,)lq|1nBY5p[)weIYRA݇^g7P+@H!qzl0n%=E MVΨ\m;,Ȳʴڅ!-d0nZtC2g\g- HW76ttʺB-l'7ƕym1f'bH@B^zK97'хf? hd@S<0HhzKƛ㌆Dr|w FIz Y:K g=R;9m%hzLNy`Y<\O <TX@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???SK$??6?1@X9??`C?`C?`C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14y,PNG  IHDRc IDATxy|TwNHI }% @EVQѺTiimmhZZ"Z"."" k’$@~qLfN&z s>s|3Ȉ豄Fb5<Ғ .@FY\zk[\5't&^|.]8:S8ã9!!A`sZ;y[42pq@nP4pӒ_C"~/( ˎ,tz"BǓy%"ADh4aC 1G :ZZßYmzaF5!qDŢyuzѼ)`7bsX9ph a!Cĸ1_ Qgd d l덪L& GWQy 7U3$b8_Fl&潞Kf|Ik!)1 as4a7ƛWkWS}NMMeIDID] Y5=Ғ0fɲZI <ꝝaJ<$%)c u po]f_*c4BLD'j*H"T]%MFa5%"yPDACt,}5 |WxZd"ÆD'Z{&|S|cHy\Ik]L$w)..Ս)H F(:iQxȽ$(M*"IvIieIGmo$`ԛeӮ7B2SYy*>x[KPxg ]"-i2좕Jyswjp s$7Xܵ֯LŌ#y&zA%רHfȲ e$YB$$,K1݉o>^g@R^#!eR@&] _?T_kfAzRxOn? xg$({z864 Z@k@7"J.,zގ;K<ϔ%TV|Ywg- 'e&,N3ږ+x(~hCRԖpd/Hu&#i&դAoƨ7bЇ`ԛq8m<]A֠$Ĵk<yBj-*" 3_%-0zOm#I*/|Ӳ}PSHB*♞w5,b5PU}À_$It  WA8E{~֜} X<\$I4YkqNӻETrjoow6<A}s-sU\=6zxJriֱ}K(E'#E4h-Aß_I@ye.`R|O xM[HDH4ZVF@(|ǫ}R.(s!a(NGN춍jUjM$NRLB4^c2(aLq2=Ұx!eLD" WKK,\>=hS|~8eO IJVG<ы:y_.5tHʸ3=iG4U>x\A)JiKdIOO CrŞϻ' G'|^66Eœ5~q#RpN>Ş-U 2(o4&y*PIs IV"{K-zFaNW)haV)oowO~bcdK=\qz|j`#uє%j*_% M[2P~ FDGbw8sX-Oq"FQS/wj̅'K@-ɝ,\qRZZ{BD3ҔO9?=o{#&pzE[<>UGi& gLsC]!?u:L%/h}L5/wMtd,QeKM*f4 z#o}.ߧ;-yoh0SVQ76pcrSfz@y )J~l ۾Yߥ'7;yhmJM%%!!ywƟDS 1|U gAM˦9rj'}®Cxdadrϸ  A _uN{Ϯjģ\4t/ؼg{94vT&.щ`F!N|: 0+~mVh5Z4U@=N+ f儆 іRAi&Sg9?02ބ$IHKt"JNΞ/󤙒?QrtٻJqsmA9p|ks'&~x,&>.:y._Aohv/wɗ"G6z5_w9c6hh4ZtZ=z'=ؼg_35ױ;nK@V}^pXq. 6N,EFSUST;VOiZ.TmƲ%5?f[|#†*s@V'[cBQ }3""B4Վ%2'AoЪٚ~z Qr\;Éӽ,8ؔ^y2]cձճ\YVWNl E{_>iy%Ϫ yNQH_L§KUVrZluXm:u'8p|+a˜vK">˫}&,KeQ  ~ /`;L]@"$4l-}ڞd<5Ov%HehL@dMxW) >3^YU;=@˰-Je_UŃR 24?iu~JVHm\==2M#aD\AiIq\vN;I4wHjS~ Oˎ%QP*^ruYy>Bw5@~ıE[.l 8saDuHHNx?8_S=&g]ΰ!ihfC/f3e'*_.UqNC7NuDz z3:AVق t~;4 Ӫ~RS= b6씙 pzǍ h-DR\:ˁipz΀(9yG: 1GWA ¨aɲ maz/bwpDg͵\8ŒkOw,n|uL1B~sw܈ \vDIeXV.֝QY?Ï~hzX7=y ؑ+fߟ:#9>FQo>j:Oey&"S!BLMajⵏ~wIRIhMءIFtUstKn%_ÊiW̱U'AH~{EG|hL[vK62Q Utّ$d>u_/g…#י;&zLN0x&Ħb6j$F1fmkd1c dɳY8M~W:=p|' ǰI1e.d7vx!#j C[]waC܎ɳ;}q%^-HHρZ?tͣgXb[ɗ Y[U!9./0cA wy'[jZk3P4ٛ;D'穮;rPfxd?hu(LL hڝP~í꯽y4gL5Ȁ]hu111lܸ邂rrr_&11_~<#+\^<̗QQò=j1NNgYȩi=ԉ0߸6/Lfo=dYkIKR%23wb)k宁Du^{۷}vrssٵk[m殻bk`azZ2]P&>NG)/Ah͡@}^w^T7jt5VP=8ZǷ_ꠥQ]6'oPsϵ]lv橢"9¾c_u.\ȣ>aGy錊2_~Qx5E9+^K߂^glS4g\nGt8%عEkɓ'B~~>FbٲeYUۚc {ת5Џ̞_Aoe;e(/}x8٭ d':BAVXӺQo&2l(pwe -y2׵y3ŵ.#SV˦(ز,󁟎 fހnpp:8zrj+:^˛{`֬Ysi*cEYpϹX{KJh"~󟷛&==}xT2ғ"J"/k{~ӁϹK+FKr< R2<:k]RVצ'O̙7syǏe's\ 6zC"Fe_{o6:bj-)cEWad/^ҥK曻U澤Q2.u QFs6[?XeiS_VխӅ(IkҰ8/k"IOOGE<3'@#h94oi^}U/_ޝbZ\pF^(T¤N\"Ò6wFwAP\BoDTlqa|{2`HMM%qrbdK.CW9qb7rn'N(`%GsrW{}Nq7)˻tpNW X*Bk#|tS ԊN /t;oAwh񙠔қؼMdYfWv9;,0& g]KDxfS:F٩;x_W|wf]+{9/‹/rݪKHÇy0a~{Z+g `x*}*ec *{nKH"# 3k*637{R}5nwS'LСC-I֜yII 6͒Vm qpmw<)ً}P|Qbntm϶Z1$_~t? W\ŬYu6&&U9 b28I†1$bC~FyDAFf԰q||ʕLWHfu* NNN{6ODŽ I&/{{$0a$Nbe ޢ_< ΣHEY9ڱFb۱pxDq)D0,:.A$IQ#DI&;; 6?Zjilnr[+.t,C5pˏx7->6TQ]_i% }Aիy'<>BnNU6;MEFFve{٬\NDQhCIA3($KܸAE$"jc廩>EM]%aсnL cnfEW+r|7r+ywdϪUHOL$o4 ۶uęo8~z/Oddd|WȲd%3g;06bw+A@]eW'ô-e[> n[?So?qdѮPI0C` ɀiCDpq<ۯ_k*O9n<8[}ll6=ݻ_*~0,zDْi"RJ[+߭m%7.zVшNch04ޠ8&Sk 4IDATȻϗPRR/~+$IxyZGlud۶)#JNuŧ_+W@GOjo",$tf좕&[-bؐx7i>4o`!ɢ!R᏶iyWy1#PwFk kjt(/>?cy3ڞOOS.uBr/olNX<[Yϱ86&uڶ pB8HXn_~y 2 Z$UD4[m:t3mWZEmm-yK4@FHB!WgСw R{ X~W^,o|M7?Sf͚;q'cc_رC\"ڕmoDףw{{Yf4殾jƏO~~>W͞ݶ8й'F MFb-%rT[5y#hxvGZYY1c{ôXW<3<êUz 3TwmBG5)bgS]/x3-*_ pş\A/ [5_OiZɎb VGDB"(H،w)]JBl [ c'au4TMM}%6A: tačHXHϾ~w#:*1 VY_nnB# 44UST6A'FWȘ^g:`ų ̆PD g8BaF$YD5WboRKYŞ`> =_!VRqy8.s c&10CqNĦ1z.TWrl~Z^zx#U5'9^A'su7I ",狝3>!D.TRVwP8.w?aC9!#X%̀isjM9/{Śs<{/w s t92ظ\Ej$<4 F$K XmonbbM%eK)=<)6pXq y#k Ȳl?so0rɤ5\Bi>JGY2JL–\\B}E/RQyxp[HPZ1Cq844USY}rS-&hY~ j+:̑; ngeHuk L% 9ߩ{ (u^gZOtnjuVWyϺ, a5ɕN'h7эA"Uէ8tS9<VF ##ɒVOF覾. ݁3G2ބ^g@pڔJK5Ob:ȷO'eLGNW .gAiIn4Ȁ=1H[y* ng}v/z n7[.4 @-YC-رյ n BPg@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???C;$??& @@5^@?@!?@!?@!??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15o5PNG  IHDRc IDATxy|TwLH- a * nкۺii}jM}֪UK[mR wQd!=̐=@]ιw9J4Ȣi +#;?ǟm-:{D"AB:jr˻IA~dIAdIFdz[ءsP'SHE?o*#KξC`-D]cTNzgGUTdYA P]w4؍j:%͟OfY86mEa"Z@ICedd$$IhNK4WF.}٣/MB(hWT% TRUw꺣l~6pH$eϪ<}AQXCBfl|T<YV0L  R!w8ՏNHB"ɧ/yv @8@U<3HMG!&i עQ]s㰆a)B(Usz!c_7C$ΜGV! Xsy0` ˬ y ͟And[IJyE<34#;+-Gd|n0c"H=Pd-yR0}޴u& B|MHԯ@>V;ghLq!4 L4un}U0LI0u!I$#r9/}^J "IA0Vo|] _A%Oň!}K"_1iv+Ik/neqUGۿoωZ´& 4$m<] <4&G*!t&ُ^=jl$I ox?Cs GsӕHs^kc}<odµ3W !@3>if&KHPr{ӕ +Tw;lǪʩ=H$d޴ooYeIVn!@Ua[qhoY%㇝9 3`,d+iZk ;[t5 $I̟~Cr^${<~Y!ݟMo !m?GHH ?ӱ a'd/&OÐ1\0fk!K zWE=ȡ_xo|Rbb-#}Ka SgKͪBXz-{V6h<х]DZj:問faG2,#K2Q$߃8<^6U]w Q%bS$fy<]dXzeA-GJ ߽:H4@m}%Z C YtZVMinB-0wisG)?k˿ƗCQL$ 8xl'jj.iǓ"{_فdV|nwv"  GuJ7G„Ak Y?aH]CG3M0l>^O ^O CYpnd[AT  ꨨ9Hmsw% DDD"ap=vQ[W5Up%xU0^ՇWMcYe=i[mэ(]˄vs٣/#I %GFꩨ9H]V4Gڅ*WV݋Gd><^;?,QtތhB;9 3Lt݊8VU@4kH9V{\y3M(MJxnhjm93U G ET4k hh#Zxw8pt;59vMsY[E>[J¹O|Kئqɜ;sӉ=ⵈc#uks;'.b)>TCe1z[;QUQ=F744Csct+#Ub 0k 4=i Q-n"N4` TVX'F/쉽Wu͚&?iH@$0 kq~ku~^\ԇW> ^ dqxxÇs[r=zMRUk\ .BQyN86Pv { h dfdPV4. *P*s}:Gӣen$Yx<>6y5[ h"D#盖qBddfQ[Mg$4#{Qd_lj] #m<ǧ_S^9$Iodg;KgG2m"*3dp FkTmkCg_ڨ1:~ijiT]K@F]µΥO}@z^7X YV8INXuFh>4=b鄢!Vojٽ)hFu s _;SSdݺM}SvWdYE$L8i},_n10o8#RU{?xUOu>:Q]eZ_jaя>lѺ_B㚬GFjoTC8b!+<^iGOؼ%c}ʕ{K((lHLbF6Cz/f=ӨKy9{?^A OywrWG8y7$[ĂN.x-?!Vz#P ϻn?|)X y? 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KdgZJ^10od,E]4 vh?iJP_/Hf 4xHO$W}(*N{|pc?JZJ\^ahD@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! 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EVL8ɧΙ{#s ѴP($et$᰻+u҅4]#0yI-S=23j_a&g]' :~dt$C=zx8u玠`rJX >RRegǺFwYZp9SLQPįϷedk8D}S`E1y|qKAX (vf"@G ȠBƣ|L0O?Fn$Ҭ]~X^!4GN`R2V gy$MzJ6ZlB2w^ah! 4SYw,R\!dYONOMW:vi`X 59`B LY+M$ó;F݌jbG#vd"*( ŕNCZ"zQ0 BѺBZ("@$HH &I-O#O0WЏum!۷Dc9yhʺƆhWyniV43L!guؓZa&_+>ǝWH~].4n{ɓT-l*QJe_#2k–"#-7n;A8!rj73N3N05SPjlv t5n4*w!bȎe$HzKDFX7L'Q!<}q*7m~RX#1m#zgfP.g g| 5^6\N] #rgnHnu\Vۋ>1U_d'<~G ߍtχRMn'og(B{WW}ԋ=\̤ hEoĦ8p؜$9됑%EbƏ8[ϣj!4Ze\owXˮk7PMtL/;:)Enp/N|I=<`V49SgSՅNX X0kf|نnU1A19p]3Ƹ6Tsj7eF\JG҅ddpցdA\4=nk:$I|տ1ln[D|~7a5hDjrt-ګx4}L8ieMёh7bfpN46PRGd;NG!l3q{K4LgtuF;J.3rb(a< E_weOw飷 {HMz= IX d䓯z=g5LC7,k0Hz۱+vȊ YhFt :PPd;@5a9MG@<GeGh~H9.$;>>bjڼ#N|˾_=1Wܸ i}B]/꽦UXjO]l222% AjQxZʖ]Rq\8lΗHvS+P`؇-&]cz#^Hbޏd_ ƹn{:p!8@5z/8ȦMسVWetRԱk:{w8ToR$Drj2)i);5&%^O=Fw5r|#g-vrYklefUSekI00wd  OKX+pab`;l&[2xoB|7_(_QՎno=aa(,ҩ6$!ŕAng cID ͠Dmݻۖ'_^ߍj'O>P8h*ƴ/dۿj\gS24:!755 ßf#)#e@!+=bEm` M),w3P(&$ITՕ TyYCx(e޼Cn0x|M4ԓվ-pF-lɩ B>A/a5Ĕ$^[~+Y-a+n44cSM?Mh]W 8 QVŜwBĪvIENDB`move=1000;blend=1000;3OSUSd d U_UUWUUUUUW꪿O3?L| A/CZBUVT5ԇoRAUI!/j֭֠uCU?PCZ[* P_!*R֠j֠)*T H*UWR֠j P_("$H$H$D"D"D"DH"$$D"D"DH"$HL WpWfW#yvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13OSUB1d@,.y`,.y6|  BPUAAAT_H?ZjPjO/BK֩ jZ֪U P֡jH5_ZTZZ֪B_Zʅ$D"D"D"DH"$H$H$D@H"$H$H$D"Z֪֡jժ$kUZ'/jԟR m_Z֗R jծH?USU֪j֡BeB/ZkkP ֩ H?USZP $H$D"D"D"DH"$H$H $$"DH"$H$H$D BTUURI֪  jO_A?֤KP /Z/]jZ֪T/BZʅ_ ֡jR jjZ ֡j*H$H$D"D"D"DH"$HII"D"DH"$H$H! B\!p fDDI'DDDIIIDDI$I$"""''$DDDD! I$!BI$DDI""$"""$I"""I?H$HB??""""$AI?BI$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTI$'y$DDI'I$I$B @I$! $I$O䈈$$""$I!BDDD$$II$!BI$DDIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPI$DD$DDD$$DDI$O"""DDDDIB $O$DDI$""I?"""O""$$I$!""""I$OI$! $I%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@kvbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg a 247ac1]1vbinding site for residue peg a 248ac21vbinding site for residue peg a 249ac3031vbinding site for residue peg a 250ac4Y[1vbinding site for residue peg a 251ac5J1vbinding site for residue peg a 253ac7451vbinding site for residue peg a 255ac9>@1ubinding site for residue mg a 256bc1)1ubinding site for residue mg a 257bc2Y1vbinding site for residue po4 a 259bc4T1vbinding site for residue peg b 247bc51met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESHH1met->mse selenomethionine MOD_REScc1met->mse selenomethionine MOD_RESee1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue peg b 249bc7{{1vbinding site for residue peg b 250bc8UW1vbinding site for residue peg b 251bc91met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RES__1met->mse selenomethionine MOD_RESaa1met->mse selenomethionine MOD_RES||1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12UVD_; _; 's7\m!p f$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$F1mi$oi$omlmoI oI$lBcmm$mmmi$AII66b/I$mI6 F1!m@D&i$mcm$oI$ m$mlcmB?I&m$I !m! I6cI&I&mmMmi$mI6?m I6cI&I&I6I&mImI$m1Bmm1mmi$ Mmm$oI$c1aBommcm$oI$II61؄! i$I$ cBoBmMUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@?333333?333333?333333???????@???0K;?333-oxoacyl-[acyl-carrier-protein] reductase; chain: a, b; synonym: 3-ketoacyl-acyl carrier protein reductase; ec: 1.1.1.100; engineered: yes3OSU3osu P 31 2 1 BBC7??@ ab???zz?@NHU'??? AAHHHHHHHHHMMHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWdaa(          pffff ffffff ffBfff fffffff ffffffffffffff fffffff ff\pp!!!fffffffffffff ffffffbb        f ffffff ffffff fffffff fffffffff fffffff fffffppffffffffffffff ffffffccccaapegXpegdi(hydroxyethyl)etheraapeg2 funXpegdi(hydroxyethyl)etheraapeg3s from tXpegdi(hydroxyethyl)etheraapeg4:@ Xpegdi(hydroxyethyl)etheraapeg5[ TY Xpegdi(hydroxyethyl)etheraapeg6  Xpegdi(hydroxyethyl)etheraapeg7Xpegdi(hydroxyethyl)etheraapeg8Xpegdi(hydroxyethyl)etheraapeg9Xpegdi(hydroxyethyl)etheraamg'|aamg2'|aapo4s aapo42s  Bbbpeg#K1Xpegdi(hydroxyethyl)etherbbpeg2B+ޯ Xpegdi(hydroxyethyl)etherbbpeg3_= 9Xpegdi(hydroxyethyl)etherbbpeg4Fr?!˰Xpegdi(hydroxyethyl)etherbbpeg5׹ŅXpegdi(hydroxyethyl)etherawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108 _mse  _lys      _mse  _thr ! _lys ! "$)!#"!%$&%'&('* Eser "*)+-/*,+*.-0 Eala +0/13402105 Eleu15468<576598:;99=  Eval6=<>@C=?>=AB@@D  _thr>DCEGJDFEDHIGGK  _glyEKJLNKMLO  _ala LONPRSOQPOT  _ser PTSUWYTVUTXWZ _arg UZY[]dZ\[Z^]_^`_a`bcaae Hgly[edfhegfi Hilefihjlpikjimnlolmq Hglyjqprtqsru Harg rutvxuwvuyxzy{z|{}~|| Hser v Hile Hala  Hleu Hgln  Hleu Hala  Hglu  _glu  _gly _tyr  Easn Eval  Eala ! Eval" Easn# Etyr $ _ala % _gly   & _ser        ' Hlys  ( Hglu " !#) Hlys #"$&+#%$#'&(')(*),* Hala $,+-/0,.-,1+ Hglu -10249132154657866:, Hala 2:9;=>:<;:?- Hval;?>@BE?A@?CDBBF. Hval@FEGILFHGFJKIIM/ Hglu GMLNPUMONMQPRQSTRRW0 Hglu NVWUXZUX[dVWYXV\W]Z^[_\`b]ac^_^_e1 HileXedfhlegfeijhkhim2 Hlys fmlnpumonmqprqsrtsv3 Hala nvuwyzvxwv{4 Glys w{z|~{}|{~5 _gly|6 _val7 _asp8 Eser 9 Ephe : Eala ; Eile< Egln = _ala > _asn? _val@ _ala A _aspB Hala C HaspD Hglu E HvalF Hlys G Hala   H Hmse         I Hile J Hlys " ! #K Hglu #"$&+#%$#'&(')*((,L Hval$,+-/2,.-,01//3M Hval-3246935437866:N Hser 4:9;=?:<;:>=@O Hgln ;@?ACH@BA@DCEDFGEEIP Hphe AIHJLSIKJIMLNOMPMQNRORPQTQ _glyJTSUWTVUXR _ser UXWY[]XZYX\[^S _leuY^]_ae^`_^bacdbbfT _asp_fegimfhgfjikljjnU EvalgnmoqtnponrsqquV Eleuoutvx|uwvuyxz{yy}W Evalv}|~}~}X Easn~Y _asnZ _ala [ _gly\ _ile] _thr^ _arg _ _asp` _asna _leub _leuc _msed _arg e _msef _lys g Hglu h Hgln        i Hglu     j Htrp # !"" !$k Hasp$#%'+$&%$(')*((,l Hasp%,+-/3,.-,0/12004m Hval-4357:46548977;n Hile5;:<>B;=<;?@>A>?Co Iasp<CBDFJCEDCGFHIGGKp IthrDKJLNQKMLKOPNNRq IasnLRQSUYRTSRVUWXVVZr IleuSZY[]aZ\[Z^]_`^^bs Ilys [bacejbdcbfegfhgihkt Hglyckjlnkmlou Hvallonpruoqpostrrvv Hphe pvuwyvxwvzy{|z}z~{|}~w Hasnwx Hcys y Hilez Hgln { Hlys | Hala } Hthr~ Hpro Hgln  Hmse Hleu Harg  Hgln  _arg  _ser  Egly Eala  Eile    Eile        Easn  Eleu" !# _ser #"$&(#%$#'&) _ser $)(*,.)+*)-,/ Hval*/.025/10/34226 Hval06579<6876:;99= Hgly7=<>@=?>A Hala >A@BDEACBAF HvalBFEGILFHGFJKIIM _glyGMLNPMONQ _asnNQPRTXQSRQUTVWUUY _proRY^XZ\_Y[ZY]\^X]` _glyZ`_ac`bad _gln adcegldfedhgihjkiim Hala emlnpqmonmr Hasnnrqsuyrtsrvuwxvvz Htyr szy{}z|{z~}~~ Hval{ Hala  Hthr Hlys  Hala  Hgly Hval Hile Hgly Hleu Hthr Hlys  Hser  Hala  Hala  Harg  Hglu  Hleu Gala  Gser        Garg      _gly Eile# !" $ Ethr$#%'*$&%$()''+ Eval%+*,.1+-,+/0..2 Easn,213592432657866: Eala 3:9;=>:<;:? Eval;?>@BE?A@?CDBBF Eala @FEGIJFHGFK EproGKPJLNQKMLKONPJOR _glyLRQSURTSV _phe SVUWY`VXWVZY[\Z]Z^[_\_]^a BileWa`bdhacbaefdgdei Gvalbihjloikjimnllp Gser jpoqsuprqptsv Gaspqvuwy}vxwvzy{|zz~ _msew~}~~ _thr _asp  _ala  _leu _ser  Hasp Hglu  Hleu Hlys  Hglu  Hgln  Hmse Hleu Gthr Ggln  _ile _pro _leu          _ala   _arg   _phe  !#* "! $#%&$'$(%)&)'(+ Bgly!+*,.+-,/ _gln ,/.027/10/324356448 Hasp0879;?8:98<;=><<@ Hthr9@?ACF@BA@DECCG HaspAGFHJNGIHGKJLMKKO HileHONPRVOQPOSTRURSW Hala PWVXZ[WYXW\ HasnX\[]_c\^]\`_ab``d Hthr]dcegjdfedhiggk Hvalekjlnqkmlkopnnr Hala lrqsuvrtsrw Hphe swvxzwyxw{z|}{~{|}~ Hleux _ala  _ser  Gasp Glys  Gala  _lys  _tyr  _ile _thr _gly _gln  Ethr Eile Ehis  Eval _asn _gly _gly      _mse        _tyr    _mse  !$ "#!! %$&%'&) _lys )(*,1)+*)-,.-/.0/2 Eser *213572432658 Eala 3879;<8:98= Eleu9=<>@D=?>=A@BCAAE  Eval>EDFHKEGFEIJHHL  _thrFLKMORLNMLPQOOS  _glyMSRTVSUTW  _ala TWVXZ[WYXW\  _ser X\[]_a\^]\`_b _arg ]bacelbdcbfegfhgihjkiim Hglycmlnpmonq Hilenqprtxqsrquvtwtuy Hglyryxz|y{z} Harg z}|~}~} Hser ~ Hile Hala  Hleu Hgln  Hleu Hala  Hglu  Gglu  _gly _tyr  Easn Eval  Eala ! Eval" Easn# Etyr   $ _ala         % _gly & _ser ' Hlys ! "( Hglu "!#%*"$#"&%'&()''+) Hlys #+*,.3+-,+/.0/10214* Hala ,4357846549+ Hglu 598:<A9;:9=<>=?@>>B, Hala :BACEFBDCBG- HvalCGFHJMGIHGKLJJN. HvalHNMOQTNPONRSQQU/ Hglu OUTVX]UWVUYXZY[\ZZ^0 Hglu V^]_af^`_^bacbdeccg1 Hile_gfhjngihgkljmjko2 Hlys honprwoqposrtsutvux3 Gala pxwy{|xzyx}4 Glys y}|~}~}5 _gly~6 _val7 _asp8 Eser 9 Ephe : Eala ; Eile< Egln = _ala > _asn? _val@ _ala A _aspB Hala C HaspD Hglu E HvalF Hlys             G Hala        H Hmse           I Hile                J Hlys       $      ! " ! # " %K Hglu   % $ & ( - % ' & % ) ( * ) + , * * .L Hval & . - / 1 4 . 0 / . 2 3 1 1 5M Hval / 5 4 6 8 ; 5 7 6 5 9 : 8 8 <N Hser 6 < ; = ? A < > = < @ ? BO Hgln  = B A C E J B D C B F E G F H I G G KP Hphe  C K J L N U K M L K O N P Q O R O S P T Q T R S VQ _gly L V U W Y V X W ZR _ser W Z Y [ ] _ Z \ [ Z ^ ] `S _leu [ ` _ a c g ` b a ` d c e f d d hT _asp a h g i k o h j i h l k m n l l pU Eval i p o q s v p r q p t u s s wV Eleu q w v x z ~ w y x w { z | } { { W Eval x  ~    X Easn  Y _asn  Z _ala  [ _gly  \ _ile  ] _thr  ^ _arg   _ _asp  ` _asn  a _leu  b Gleu  c Gmse  d Garg   e _mse  f _lys   g Hglu          h Hgln           i Hglu                    j Htrp      %            !    "  # $ ! $ " # &k Hasp  & % ' ) - & ( ' & * ) + , * * .l Hasp ' . - / 1 5 . 0 / . 2 1 3 4 2 2 6m Hval / 6 5 7 9 < 6 8 7 6 : ; 9 9 =n Iile 7 = < > @ D = ? > = A B @ C @ A Eo Iasp > E D F H L E G F E I H J K I I Mp Ithr F M L N P S M O N M Q R P P Tq Iasn N T S U W [ T V U T X W Y Z X X \r Ileu U \ [ ] _ c \ ^ ] \ ` _ a b ` ` ds Ilys  ] d c e g l d f e d h g i h j i k j mt Hgly e m l n p m o n qu Hval n q p r t w q s r q u v t t xv Hphe  r x w y { x z y x | { } ~ |  | } ~   w Hasn y  x Hcys  y Hile  z Hgln   { Hlys   | Hala  } Hthr  ~ Hpro   Hgln    Hmse   Hleu   Harg    Hgln    _arg    _ser   Egly   Eala        Eile              Eile              Easn                  Eleu     $     ! " # ! ! % _ser  % $ & ( * % ' & % ) ( + _ser & + * , . 0 + - , + / . 1 Hval , 1 0 2 4 7 1 3 2 1 5 6 4 4 8 Hval 2 8 7 9 ; > 8 : 9 8 < = ; ; ? Hgly 9 ? > @ B ? 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