F3.6-1h/data/swissprot/ 3OTR.pdbdupa 1TE6.pdbE[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]2.75 Angstrom Crystal Structure Of Enolase 1 From Toxoplasma Gondii[/h3] [p]G.Minasov, J.Ruan, L.Shuvalova, A.Halavaty, H.Ngo, S.Tomavo, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3OTR" target="blank"]3OTR[/a] [small](deposited on 13-SEP-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1TE6.pdb3OTR a_3OTRB1  1TE63csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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C @ C A B E _pro < E J D F H K E G F E I H J D I L _lys  F L K M O L N M L P O Q P R Q S R U _met U T V X \ U W V U Y X Z Y [ Z ] _val V ] \ ^ ` c ] _ ^ ] a b ` ` d _val ^ d c e g j d f e d h i g g k _ile e k j l n r k m l k o p n q n o s _lys  l s r t v { s u t s w v x w y x z y | Easp t | { }  | ~ } |    Eile }   Eval   Eala   Earg    Eglu    Eile   Eleu   _asp   _ser   _arg    _gly   _asn   Epro   Ethr   Eile   Eglu   Eval   Easp         Eval Eser  Ethr" !# _glu #"$&+#%$#'&(')*((, _gly$,+-/,.-0 Egly-0/130214 Eval14357:46548977;  Ephe 5;:<>E;=<;?>@A?B?C@DADBCF! Earg <FEGIPFHGFJIKJLKMLNOMMQ" Eala GQPRTUQSRQV# Eala RVUWYZVXWV[$ _valW[Z\^a[]\[_`^^b% _pro\bgacehbdcbfegafi& _ser cihjlnikjimlo' _glyjonproqps( _ala psrtvwsutsx) _ser txwy{}xzyx|{~* _thry~}~~+ _gly, _ile- _tyr . _glu / _ala 0 _leu1 _glu 2 _leu3 _arg 4 _asp5 _lys 6 _asp7 _pro8 _lys 9 _arg : Gtyr           ; Gleu< Ggly= _lys # ! "!$> _gly$#%'$&%(? _val%(')+.(*)(,-++/@ Hleu)/.026/10/3245337A Hasn0768:>7987;:<=;;?B Hala 8?>@BC?A@?DC Hval@DCEGJDFEDHIGGKD Hglu EKJLNSKMLKONPOQRPPTE HileLTSUW[TVUTXYWZWX\F IvalU\[]_b\^]\`a__cG Iarg ]cbdfmcedcgfhgihjikljjnH Igln dnmoqvnponrqsrtusswI Iglu owvxzwyxw{z|{}~||J IilexK Hlys L HproM Hala N HleuO _leuP _glyQ _lys R _aspS _proT _cys U _aspV Hgln W Hlys X HglyY HileZ Hasp[ Hmet\ Ileu       ] Imet    ^ Ival_ Iglu $ ! "#!!%` Igln %$&(-%'&%)(*)+,**.a Ileu&.-/15.0/.2134226b Iasp/6579=6876:9;<::>c _gly7>=?A>@?Bd _thr?BACEHBDCBFGEEIe Elys CIHJLQIKJIMLNMONPORf EasnJRQSUYRTSRVUWXVVZg _glu SZY[]bZ\[Z^]_^`a__ch _trp [cbdfpcedcgfhigjgklhkijminkolomnqi Eglydqprtqsruj Etyr rutvxuwvuyxz{y|y}z~{~|}~k _ser vl _lys m _ser n _lys o _leup _glyq Hala r Hasns Hala t Hileu Hleuv Hglyw Hvalx Hser y Hilez Hala { Hcys | Hcys } Harg ~ Hala  Hgly    Hala         Hala   Hser  Hlys # ! "!$ _gly$#%'$&%( _leu%(')+/(*)(,+-.,,0 _pro)05/1360210435/47 Hleu1768:>7987;:<=;;? Htyr 8?>@BJ?A@?CBDECFCGDHEHFGIHK Hlys @KJLNSKMLKONPOQPRQT Htyr LTSUW_TVUTXWYZX[X\Y]Z][\^]` HileU`_acg`ba`decfcdh Hala ahgiklhjihm Hthrimlnpsmonmqrppt Hleuntsuw{tvutxwyzxx| Hala u|{}|~}| _gly} _lys  _thr _ile _asp _lys  Emet Eval Emet _pro Eval Epro Ephe  Ephe  Easn _val Eile Easn         _gly Ggly Gglu   Ghis  !#) "! $#%&$'$(%(&'* _ala !*)+-.*,+*/ _gly+/.02/103 _asn03246:3543768977; _gly4;:<>;=<? _leu<?>@BF?A@?CBDECCG _ala @GFHJKGIHGL _leuHLKMOSLNMLPOQRPPT _gln MTSUW\TVUTXWYXZ[YY] Eglu U]\^`e]_^]a`bacdbbf Ephe ^fegipfhgfjikljmjnkolomnq Eleugqprtxqsrqutvwuuy Eileryxz|y{zy}~||} Eala z _pro _val _gly _ala  _pro _asn Hile Harg  Hglu  Hala  Hile Harg  Htyr  Hgly Hser  Hglu  Hthr Htyr             Hhis  Hhis % !" # $!$"#& Hleu&%')-&('&*)+,**. Hlys '.-/16.0/.213243547 Hasn/768:>7987;:<=;;? Hval8?>@BE?A@?CDBBF Hile@FEGIMFHGFJKILIJN Hlys GNMOQVNPONRQSRTSUTW HasnOWVXZ^WYXW[Z\][[_ Hlys X_^`bg_a`_cbdcedfeh Htyr `hgikshjihlkmnlolpmqnqoprqt _glyitsuwtvux Gleuuxwy{xzyx|{}~|| Gaspy Gala  Gthr _asn Bval _gly _asp _glu  _gly _gly Bphe  _ala  _pro _asn _val _ala  _thr Hala  Hglu  Hglu   Hala          Hleu   Hasn Hleu!% "!#$""& Hleu&%')-&('&*)+,**. Hval'.-/14.0/.23115 Hglu /5468=576598:9;<::> Hala 6>=?AB>@?>C Hile?CBDFJCEDCGHFIFGK Hlys DKJLNSKMLKONPOQPRQT Hala LTSUWXTVUTY Hala UYXZ\]Y[ZY^ _glyZ^]_a^`_b _tyr _bacembdcbfeghfifjgkhkijlkn _glu cnmoqvnponrqsrtussw _glyowvxzwyx{ _lys x{z|~{}|{~ _ile| Elys  Eile Eala  Ephe  Easp _ala  _ala  Gala  Gser  Gglu  Gphe  Etyr  Elys  _gln  _asp _glu         _lys       Elys   Etyr  "*! #"$%#&#'$(%(&')(+  _asp +*,.2+-,+/.01//3  _leu,3246:3543768977;  _asp4;:<>B;=<;?>@A??C _tyr <CBDFNCEDCGFHIGJGKHLILJKMLO _lys DONPRWOQPOSRTSUTVUX _cys PXWY[]XZYX\[^ _lys Y^]_af^`_^bacbdcedg _thr_gfhjmgihgkljjn _lys hnmoqvnponrqsrtsutw _asnowvxz~wyxw{z|}{{ _ala x~ _ser  _lys  _his  Bleu _thr Hgly Hglu  Hlys  Hleu Hlys   Hglu ! Hval" Htyr # Hglu $ Hgly% Htrp   & Hleu         ' Hlys  ( Hlys # ! "!$) _tyr $#%'/$&%$(')*(+(,)-*-+,.-0* _pro%05/1360210435/47+ Bile1768:>7987;<:=:;?, _ile8?>@BF?A@?CDBEBCG- Eser @GFHJLGIHGKJM. EvalHMLNPSMONMQRPPT/ Eglu NTSUW\TVUTXWYXZ[YY]0 _aspU]\^`d]_^]a`bcaae1 _pro^ejdfhkegfeihjdil2 _phe flkmovlnmlpoqrpsptqurustw3 _aspmwvxz~wyxw{z|}{{4 _gln x~5 _asp6 _asp7 Hphe 8 Hala 9 Hser : Hphe ; Hser < Hala = Hphe > Hthr? Hlys @ HaspA HvalB GglyC Gglu D Glys E _thr   F Egln        G Eval H Eile" !#I Egly#"$&#%$'J _asp$'&(*.')('+*,-++/K _asp(/.026/10/3245337L _ile0768:>7987;<:=:;?M _leu8?>@BF?A@?CBDECCGN _val@GFHJMGIHGKLJJNO _thrHNMOQTNPONRSQQUP _asnOUTVX\UWVUYXZ[YY]Q HileV]\^`d]_^]ab`c`aeR Hleu^edfhlegfeihjkiimS Harg fmlnpwmonmqprqsrtsuvttxT Hilenxwy{xzyx|}{~{|U Hglu yV Hlys W Hala X HleuY Hlys Z Hasp[ _lys \ _ala ] _cys ^ _asn_ Ecys ` Eleua Eleub Eleuc _lys d Hvale Hasnf Hgln    g Hile       h _gly i _ser j Hval #!"  $k Hthr$#%'*$&%$()''+l Hglu %+*,.3+-,+/.0/12004m Hala ,4357846549n Hile598:<@9;:9=><?<=Ao Hglu :A@BDIACBAEDFEGHFFJp Hala BJIKMNJLKJOq Hcys KONPRTOQPOSRUr HleuPUTVX\UWVUYXZ[YY]s HleuV]\^`d]_^]a`bcaaet Hala ^edfhiegfeju Hgln fjikmrjlkjnmonpqoosv Glys ksrtv{sutswvxwyxzy|w Gser t|{}|~}|x _gly}y _trp z Egly{ Eval| Egln } Eval~ Eser  _his  _arg  _ser  _gly _glu  _thr _glu  _asp _ser  Hphe  Hile         Hala   Hasp Hleu" !# Hval#"$&)#%$#'(&&* Hval$*)+-0*,+*./--1 Hgly+10241325 Hleu25468<576598:;99= _arg 6=<>@G=?>=A@BACBDCEFDDH _cys >HGIKMHJIHLKN _glyINMOQNPOR Egln ORQSUZRTSRVUWVXYWW[ EileS[Z\^b[]\[_`^a^_c Elys \cbdfkcedcgfhgihjil _ser dlkmoqlnmlpor _glymrqsurtsv _ser svuwy{vxwvzy| _prow|{}|~}|{ _cys } _arg  Hser  Hglu  Harg  Hleu Hcys  Hlys  Htyr  Hasn Hgln  Hleu Hmet Harg  Hile Hglu          Hglu   Hser  Hleu $! "#!!% _gly%$&(%'&) _ala &)(*,-)+*). _asp*.-/15.0/.2134226 Ecys /6579;6876:9< Eval7<;=?B<>=<@A??C Etyr =CBDFNCEDCGFHIGJGKHLILJKMLO _ala DONPRSOQPOT GglyPTSUWTVUX Gglu UXWY[`XZYX\[]\^_]]a Gser Ya`bdfacbaedg _phe bgfhjqgihgkjlmknkolpmpnor _arg hrqsu|rtsrvuwvxwyxz{yy} _his s}|~}~} _pro~ _lys  _arg  _ser  _his  _met _val _val _ile _lys  Easp Eile Eval  Eala   Earg   Eglu   Eile             Eleu  _asp ! _ser ! "$&!#"!%$' _arg "'&(*1')('+*,+-,.-/0..2 _gly(21352436 _asn36579=6876:9;<::> Epro7>C=?AD>@?>BAC=BE Ethr?EDFHKEGFEIJHHL EileFLKMOSLNMLPQOROPT Eglu MTSUW\TVUTXWYXZ[YY] EvalU]\^`c]_^]ab``d Easp^dcegkdfedhgijhhl Evalelkmorlnmlpqoos Eser msrtvxsutswvy Ethrtyxz|y{zy}~|| _glu z _gly Egly Eval  Ephe ! Earg " Eala # Eala $ _val% _pro& _ser ' _gly( _ala ) _ser * _thr+ _gly, _ile- _tyr . _glu / _ala 0 _leu         1 _glu  2 _leu !3 _arg ! "$+!#"!%$&%'&(')*((,4 _asp",+-/3,.-,0/120045 _lys -4357<46548798:9;:=6 _asp5=<>@D=?>=A@BCAAE7 _pro>EJDFHKEGFEIHJDIL8 _lys FLKMOTLNMLPOQPRQSRU9 _arg MUTVX_UWVUYXZY[Z\[]^\\`: Gtyr V`_ack`ba`dcefdgdheifighjil; Gleualkmoslnmlpoqrppt< Gglymtsuwtvux= _lys uxwy{xzyx|{}|~}~> _glyy? _val@ HleuA HasnB Hala C HvalD Hglu E HileF IvalG Iarg H Igln I Iglu J IileK Hlys L HproM Hala N HleuO _leu  P _gly       Q _lys   R _aspS _pro$ "%! #"$#&T _cys  &%')+&('&*),U _asp',+-/3,.-,0/12004V Hgln -4357<46548798:;99=W Hlys 5=<>@E=?>=A@BACBDCFX Hgly>FEGIFHGJY HileGJIKMQJLKJNOMPMNRZ HaspKRQSUYRTSRVUWXVVZ[ HmetSZY[]aZ\[Z^]_^`_b\ Ileu[baceibdcbfeghffj] Imetcjikmqjlkjnmonpor^ Ivalkrqsuxrtsrvwuuy_ Iglu syxz|y{zy}|~}~~` Igln za Ileub Iaspc _glyd _thre Elys f Easng _glu h _trp i Eglyj Etyr k _ser l _lys m _ser n _lys o _leup _glyq Hala       r Hasn     s Hala t Hile! "u Hleu"!#%)"$#"&%'(&&*v Hgly#*)+-*,+.w Hval+.-/14.0/.23115x Hser /5468:576598;y Hile6;:<>B;=<;?@>A>?Cz Hala <CBDFGCEDCH{ Hcys DHGIKMHJIHLKN| Hcys INMOQSNPONRQT} Harg OTSUW^TVUTXWYXZY[Z\][[_~ Hala U_^`bc_a`_d Hgly`dcegdfeh Hala ehgiklhjihm Hala imlnpqmonmr Hser nrqsuwrtsrvux Hlys sxwy{xzyx|{}|~}~ _glyy _leu _pro Hleu Htyr  Hlys  Htyr  Hile Hala  Hthr Hleu Hala  _gly _lys  _thr _ile _asp _lys     Emet        Eval  Emet! " _pro"'!#%("$#"&%'!&) Eval#)(*,/)+*)-.,,0 Epro*05/1360210435/47 Ephe 1768:A7987;:<=;>;?<@=@>?B Ephe 8BACELBDCBFEGHFIFJGKHKIJM EasnCMLNPTMONMQPRSQQU _valNUTVX[UWVUYZXX\ EileV\[]_c\^]\`a_b_`d Easn]dcegkdfedhgijhhl _glyelkmolnmp Gglympoqsprqt Gglu qtsuw|tvutxwyxz{yy} Ghis u}|~}~} _ala ~ _gly _asn _gly _leu _ala  _leu _gln  Eglu  Ephe  Eleu Eile Eala  _pro _val _gly _ala  _pro   _asn                Hile        Harg                        Hglu       $      ! " # ! ! % Hala  % $ & ( ) % ' & % * Hile & * ) + - 1 * , + * . / - 0 - . 2 Harg  + 2 1 3 5 < 2 4 3 2 6 5 7 6 8 7 9 8 : ; 9 9 = Htyr  3 = < > @ H = ? > = A @ B C A D A E B F C F D E G F I Hgly > I H J L I K J M Hser J M L N P R M O N M Q P S Hglu  N S R T V [ S U T S W V X W Y Z X X \ Hthr T \ [ ] _ b \ ^ ] \ ` a _ _ c Htyr  ] c b d f n c e d c g f h i g j g k h l i l j k m l o Hhis  d o n p r x o q p o s r t u s v s w t w u v y Hhis  p y x z | y { z y } | ~  } } ~    Hleu z   Hlys    Hasn   Hval   Hile   Hlys    Hasn   Hlys    Htyr    _gly   Gleu   Gasp   Gala   Gthr   _asn   Bval ! _gly ! !!!!!! _asp!!!!!! !!!!!!! ! !!!  _glu !! ! ! !!! !! ! !!!!!!!!! _gly! !!!!!!!! _gly!!!!!!!!! Bphe !!!!! !'!!!!!!! !"!#!!!$!!!%!"!&!#!&!$!%!( _ala !!(!'!)!+!,!(!*!)!(!- _pro!)!-!2!,!.!0!3!-!/!.!-!1!0!2!,!1!4 _asn!.!4!3!5!7!;!4!6!5!4!8!7!9!:!8!8!< _val!5!<!;!=!?!B!<!>!=!<!@!A!?!?!C _ala !=!C!B!D!F!G!C!E!D!C!H _thr!D!H!G!I!K!N!H!J!I!H!L!M!K!K!O Hala !I!O!N!P!R!S!O!Q!P!O!T Hglu !P!T!S!U!W!\!T!V!U!T!X!W!Y!X!Z![!Y!Y!] Hglu !U!]!\!^!`!e!]!_!^!]!a!`!b!a!c!d!b!b!f Hala !^!f!e!g!i!j!f!h!g!f!k Hleu!g!k!j!l!n!r!k!m!l!k!o!n!p!q!o!o!s Hasn!l!s!r!t!v!z!s!u!t!s!w!v!x!y!w!w!{ Hleu!t!{!z!|!~!!{!}!|!{!!~!!!!! Hleu!|!!!!!!!!!!!!!!!! Hval!!!!!!!!!!!!!!! Hglu !!!!!!!!!!!!!!!!!!! Hala !!!!!!!!!!! Hile!!!!!!!!!!!!!!!!! Hlys !!!!!!!!!!!!!!!!!!! Hala !!!!!!!!!!! Hala !!!!!!!!!!! _gly!!!!!!!!! _tyr !!!!!!!!!!!!!!!!!!!!!!!!!!! _glu !!!!!!!!!!!!!!!!!!! _gly!!!!!!!!! _lys !!!!!!!!!!!!!!!!!!! _ile!!!!!!!!!!!!!!!!! Elys !!!!!!!!!!!!!!!!!!! Eile!!!!!!!!!!!!!!!!! Eala !!!!!!!!!!! Ephe !!!""" !""!"""""""""""""""  Easp"" " " " "" " " " "" """"" _ala " """""""""" _ala """"""""""" Gala """""" """""! Gser ""!" """$"&"!"#"""!"%"$"' Gglu """'"&"("*"/"'")"("'"+"*","+"-".",","0 Gphe "("0"/"1"3":"0"2"1"0"4"3"5"6"4"7"4"8"5"9"6"9"7"8"; Etyr "1";":"<">"F";"="<";"?">"@"A"?"B"?"C"@"D"A"D"B"C"E"D"G Elys "<"G"F"H"J"O"G"I"H"G"K"J"L"K"M"L"N"M"P _gln "H"P"O"Q"S"X"P"R"Q"P"T"S"U"T"V"W"U"U"Y _asp"Q"Y"X"Z"\"`"Y"["Z"Y"]"\"^"_"]"]"a _glu "Z"a"`"b"d"i"a"c"b"a"e"d"f"e"g"h"f"f"j _lys "b"j"i"k"m"r"j"l"k"j"n"m"o"n"p"o"q"p"s  Elys "k"s"r"t"v"{"s"u"t"s"w"v"x"w"y"x"z"y"|  Etyr "t"|"{"}"""|"~"}"|"""""""""""""""""  _asp"}""""""""""""""""  _leu"""""""""""""""""  _asp""""""""""""""""" _tyr """"""""""""""""""""""""""" _lys """"""""""""""""""" _cys """""""""""" _ala """""""""" _ser """"""""""""" _lys """"""""""""""""""" _his """"""""""""""""""""""" Bleu""""""""""""""""" _thr""""""""""""""" Hgly""""""""" Hglu """"""""""""""""""" Hlys """"""""""""""""""" Hleu""""##"#""####### Hlys "#### ###### # # # # # # # #  Hglu ###################! Hval###############" Htyr #### #"#*##!# ####"#$#%###&###'#$#(#%#(#&#'#)#(#+# Hglu # #+#*#,#.#3#+#-#,#+#/#.#0#/#1#2#0#0#4$ Hgly#,#4#3#5#7#4#6#5#8% Htrp #5#8#7#9#;#E#8#:#9#8#<#;#=#>#<#?#<#@#A#=#@#>#?#B#>#C#@#D#A#D#B#C#F& Hleu#9#F#E#G#I#M#F#H#G#F#J#I#K#L#J#J#N' Hlys #G#N#M#O#Q#V#N#P#O#N#R#Q#S#R#T#S#U#T#W( Hlys #O#W#V#X#Z#_#W#Y#X#W#[#Z#\#[#]#\#^#]#`) _tyr #X#`#_#a#c#k#`#b#a#`#d#c#e#f#d#g#d#h#e#i#f#i#g#h#j#i#l* _pro#a#l#q#k#m#o#r#l#n#m#l#p#o#q#k#p#s+ Bile#m#s#r#t#v#z#s#u#t#s#w#x#v#y#v#w#{, _ile#t#{#z#|#~##{#}#|#{###~##~##- Eser #|############. Eval###############/ Eglu ###################0 _asp#################1 _pro#################2 _phe #########################3 _asp#################4 _gln ###################5 _asp#################6 _asp#################7 Hphe #########################8 Hala ###########9 Hser #############: Hphe #########################; Hser #############< Hala ##########$= Hphe #$#$$$ $$$$$$$$$$$$$$ $$ $$$ > Hthr$$ $ $ $$$ $ $ $ $$$$$? Hlys $ $$$$$$$$$$$$$$$$$$@ Hasp$$$$$$"$$$$$$$ $!$$$#A Hval$$#$"$$$&$)$#$%$$$#$'$($&$&$*B _gly$$$*$)$+$-$*$,$+$.C _glu $+$.$-$/$1$6$.$0$/$.$2$1$3$2$4$5$3$3$7D _lys $/$7$6$8$:$?$7$9$8$7$;$:$<$;$=$<$>$=$@E _thr$8$@$?$A$C$F$@$B$A$@$D$E$C$C$GF Egln $A$G$F$H$J$O$G$I$H$G$K$J$L$K$M$N$L$L$PG Eval$H$P$O$Q$S$V$P$R$Q$P$T$U$S$S$WH Eile$Q$W$V$X$Z$^$W$Y$X$W$[$\$Z$]$Z$[$_I Egly$X$_$^$`$b$_$a$`$cJ _asp$`$c$b$d$f$j$c$e$d$c$g$f$h$i$g$g$kK _asp$d$k$j$l$n$r$k$m$l$k$o$n$p$q$o$o$sL _ile$l$s$r$t$v$z$s$u$t$s$w$x$v$y$v$w${M _leu$t${$z$|$~$${$}$|${$$~$$$$$N _val$|$$$$$$$$$$$$$$O _thr$$$$$$$$$$$$$$$P _asn$$$$$$$$$$$$$$$$$Q Hile$$$$$$$$$$$$$$$$$R Hleu$$$$$$$$$$$$$$$$$S Harg $$$$$$$$$$$$$$$$$$$$$$$T Hile$$$$$$$$$$$$$$$$$U Hglu $$$$$$$$$$$$$$$$$$$V Hlys $$$$$$$$$$$$$$$$$$$W Hala $$$$$$$$$$$X Hleu$$$$$$$$$$$$$$$$$Y Hlys $$$$$$$$$$$$$$$$$$$Z Hasp$$$$$$$$$$$$$$$$$[ _lys $$$$$$$$$$$$$$$$$$$\ _ala $$$$$$$$$$$] _cys $$$$$$$$$$$$%^ _asn$%$%%%%%%%%%%%%%%_ Ecys %%%% % % %% % %% % %` Eleu% %% %%%%%%%%%%%%%%a Eleu%%%%%%%%%%%%%%%%%b Eleu%%%%%!%%%% %%%"%!%#%$%"%"%&c _lys %%&%%%'%)%.%&%(%'%&%*%)%+%*%,%+%-%,%/d Hval%'%/%.%0%2%5%/%1%0%/%3%4%2%2%6e Hasn%0%6%5%7%9%=%6%8%7%6%:%9%;%<%:%:%>f Hgln %7%>%=%?%A%F%>%@%?%>%B%A%C%B%D%E%C%C%Gg Hile%?%G%F%H%J%N%G%I%H%G%K%L%J%M%J%K%Oh _gly%H%O%N%P%R%O%Q%P%Si _ser %P%S%R%T%V%X%S%U%T%S%W%V%Yj Hval%T%Y%X%Z%\%_%Y%[%Z%Y%]%^%\%\%`k Hthr%Z%`%_%a%c%f%`%b%a%`%d%e%c%c%gl Hglu %a%g%f%h%j%o%g%i%h%g%k%j%l%k%m%n%l%l%pm Hala %h%p%o%q%s%t%p%r%q%p%un Hile%q%u%t%v%x%|%u%w%v%u%y%z%x%{%x%y%}o Hglu %v%}%|%~%%%}%%~%}%%%%%%%%%p Hala %~%%%%%%%%%%q Hcys %%%%%%%%%%%%%r Hleu%%%%%%%%%%%%%%%%%s Hleu%%%%%%%%%%%%%%%%%t Hala %%%%%%%%%%%u Hgln %%%%%%%%%%%%%%%%%%%v Hlys %%%%%%%%%%%%%%%%%%%w Gser %%%%%%%%%%%%%x _gly%%%%%%%%%y _trp %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%z Egly%%%%%%%%%{ Eval%%%%%%%%%%%%%%%| Egln %%%%%%%%%%%%%%%%%%%} Eval%%%%%%%%%%%%%%%~ Eser %%%%%%%%%%%%% _his %%%%%%%%%%%%%%%%%%%%%%% _arg %%%%%&%%%%%%&%&&&&&&&&& _ser %&&&& & &&&&& & &  _gly&& & & && && & _glu & &&&&&&&&&&&&&&&&&& _thr&&&&&&&&&&&&&&&  _glu && &&!&#&(& &"&!& &$&#&%&$&&&'&%&%&) _asp&!&)&(&*&,&0&)&+&*&)&-&,&.&/&-&-&1 _ser &*&1&0&2&4&6&1&3&2&1&5&4&7 Hphe &2&7&6&8&:&A&7&9&8&7&;&:&<&=&;&>&;&?&<&@&=&@&>&?&B Hile&8&B&A&C&E&I&B&D&C&B&F&G&E&H&E&F&J Hala &C&J&I&K&M&N&J&L&K&J&O Hasp&K&O&N&P&R&V&O&Q&P&O&S&R&T&U&S&S&W Hleu&P&W&V&X&Z&^&W&Y&X&W&[&Z&\&]&[&[&_ Hval&X&_&^&`&b&e&_&a&`&_&c&d&b&b&f Hval&`&f&e&g&i&l&f&h&g&f&j&k&i&i&m Hgly&g&m&l&n&p&m&o&n&q _leu&n&q&p&r&t&x&q&s&r&q&u&t&v&w&u&u&y _arg &r&y&x&z&|&&y&{&z&y&}&|&~&}&&~&&&&&&& _cys &z&&&&&&&&&&&& _gly&&&&&&&&& Egln &&&&&&&&&&&&&&&&&&& Eile&&&&&&&&&&&&&&&&& Elys &&&&&&&&&&&&&&&&&&& _ser &&&&&&&&&&&&& _gly&&&&&&&&& _ser &&&&&&&&&&&&& _pro&&&&&&&&&&&&&&&&& _cys &&&&&&&&&&&&& _arg &&&&&&&&&&&&&&&&&&&&&&& Hser &&&&&&&&&&&&& Hglu &&&&&&&&&&&&&&&&&&& Harg &&&&&&&&&&&&&&&&&&&&&&& Hleu&&&&&&&&&&&&&&&&& Hcys &&&&&&&&&&&&& Hlys &&&&&'&&&&&&&&&&&&' Htyr &''''' '''''''''''' '' '' '' ' ' '  Hasn'' ' '''' ''' ''''''' Hgln ''''''''''''''''''' Hleu'''''!'%'' '''"'!'#'$'"'"'& Hmet''&'%''')'-'&'('''&'*')'+'*','+'. Harg '''.'-'/'1'8'.'0'/'.'2'1'3'2'4'3'5'4'6'7'5'5'9 Hile'/'9'8':'<'@'9';':'9'='>'<'?'<'='A Hglu ':'A'@'B'D'I'A'C'B'A'E'D'F'E'G'H'F'F'J Hglu 'B'J'I'K'M'R'J'L'K'J'N'M'O'N'P'Q'O'O'S Hser 'K'S'R'T'V'X'S'U'T'S'W'V'Y Hleu'T'Y'X'Z'\'`'Y'['Z'Y']'\'^'_']']'a Ggly'Z'a'`'b'd'a'c'b'e Gala 'b'e'd'f'h'i'e'g'f'e'j Gasp'f'j'i'k'm'q'j'l'k'j'n'm'o'p'n'n'r Ecys 'k'r'q's'u'w'r't's'r'v'u'x Eval's'x'w'y'{'~'x'z'y'x'|'}'{'{' Etyr 'y''~'''''''''''''''''''''''' _ala ''''''''''' Ggly''''''''' Gglu ''''''''''''''''''' Gser ''''''''''''' _phe ''''''''''''''''''''''''' _arg ''''''''''''''''''''''' _his ''''''''''''''''''''''' Gpro''''''''''''''''' Glys ''''''''''''''''''' Garg ''''''''''''''''''''''' _ser ''''''''''''' _his ''''''''''''''''''''''' _his '''''''''''''''''''''' _met'''''''''''''''( _val'('(((((((((((( _val((((( ( (( ((( ( ( ( ( _ile((( (((((((((((((( _lys ((((((((((((((((((( Easp(((( ("(&((!( ((#("($(%(#(#(' Eile( ('(&(((*(.('()((('(+(,(*(-(*(+(/ Eval(((/(.(0(2(5(/(1(0(/(3(4(2(2(6  Eala (0(6(5(7(9(:(6(8(7(6(;  Earg (7(;(:(<(>(E(;(=(<(;(?(>(@(?(A(@(B(A(C(D(B(B(F  Eglu (<(F(E(G(I(N(F(H(G(F(J(I(K(J(L(M(K(K(O  Eile(G(O(N(P(R(V(O(Q(P(O(S(T(R(U(R(S(W  Eleu(P(W(V(X(Z(^(W(Y(X(W([(Z(\(]([([(_ _asp(X(_(^(`(b(f(_(a(`(_(c(b(d(e(c(c(g _ser (`(g(f(h(j(l(g(i(h(g(k(j(m _arg (h(m(l(n(p(w(m(o(n(m(q(p(r(q(s(r(t(s(u(v(t(t(x _gly(n(x(w(y({(x(z(y(| _asn(y(|({(}(((|(~(}(|((((((( Epro(}(((((((((((((((( Ethr((((((((((((((( Eile((((((((((((((((( Eglu ((((((((((((((((((( Eval((((((((((((((( Easp((((((((((((((((( Eval((((((((((((((( Eser ((((((((((((( Ethr((((((((((((((( _glu ((((((((((((((((((( _gly((((((((( Egly((((((((( Eval(((((((((((((((  Ephe (((((((((((((((((((((((((! Earg (((((((((((((((((((((((" Eala (((((((((((# Eala ((((((((((($ _val(((())()(()))))% _pro()) )))) ))))) )) )) ) & _ser )) ) ) ))) )) ) )))' _gly) ))))))))( _ala )))))))))))) _ser )))))) )))))))!* _thr))!) )")$)')!)#)")!)%)&)$)$)(+ _gly)")()')))+)()*))),, _ile))),)+)-)/)3),).)-),)0)1)/)2)/)0)4- _tyr )-)4)3)5)7)?)4)6)5)4)8)7)9):)8);)8)<)9)=):)=);)<)>)=)@. _glu )5)@)?)A)C)H)@)B)A)@)D)C)E)D)F)G)E)E)I/ _ala )A)I)H)J)L)M)I)K)J)I)N0 _leu)J)N)M)O)Q)U)N)P)O)N)R)Q)S)T)R)R)V1 _glu )O)V)U)W)Y)^)V)X)W)V)Z)Y)[)Z)\)])[)[)_2 _leu)W)_)^)`)b)f)_)a)`)_)c)b)d)e)c)c)g3 _arg )`)g)f)h)j)q)g)i)h)g)k)j)l)k)m)l)n)m)o)p)n)n)r4 _asp)h)r)q)s)u)y)r)t)s)r)v)u)w)x)v)v)z5 _lys )s)z)y){)}))z)|){)z)~)}))~)))))6 _asp){))))))))))))))))7 _pro)))))))))))))))))8 _lys )))))))))))))))))))9 _arg ))))))))))))))))))))))): Gtyr ))))))))))))))))))))))))))); Gleu)))))))))))))))))< Ggly)))))))))= _lys )))))))))))))))))))> _gly)))))))))? _val)))))))))))))))@ Hleu)))))))))))))))))A Hasn)))))))))))))))))B Hala )))))))))))C Hval)))))))))))))))D Hglu )))))))))))))))))))E Hile)))))))))))))))))F Ival)))***)**)*****G Iarg ***** ****** * * * * * * * *** * *H Igln *******************I Iglu ******"********* *!***#J Iile**#*"*$*&***#*%*$*#*'*(*&*)*&*'*+K Hlys *$*+***,*.*3*+*-*,*+*/*.*0*/*1*0*2*1*4L Hpro*,*4*9*3*5*7*:*4*6*5*4*8*7*9*3*8*;M Hala *5*;*:*<*>*?*;*=*<*;*@N Hleu*<*@*?*A*C*G*@*B*A*@*D*C*E*F*D*D*HO _leu*A*H*G*I*K*O*H*J*I*H*L*K*M*N*L*L*PP _gly*I*P*O*Q*S*P*R*Q*TQ _lys *Q*T*S*U*W*\*T*V*U*T*X*W*Y*X*Z*Y*[*Z*]R _asp*U*]*\*^*`*d*]*_*^*]*a*`*b*c*a*a*eS _pro*^*e*j*d*f*h*k*e*g*f*e*i*h*j*d*i*lT _cys *f*l*k*m*o*q*l*n*m*l*p*o*rU _asp*m*r*q*s*u*y*r*t*s*r*v*u*w*x*v*v*zV Hgln *s*z*y*{*}**z*|*{*z*~*}**~*****W Hlys *{******************X Hgly*********Y Hile*****************Z Hasp*****************[ Hmet*****************\ Ileu*****************] Imet*****************^ Ival***************_ Iglu *******************` Igln *******************a Ileu*****************b Iasp*****************c _gly*********d _thr***************e Blys *******************f _asn*****************g _glu ****+++****+++++++++h _trp@*+*+++ + ++ ++!++ +!++ + + +++++ +++++++++++++++++++++++++++++++++ ++++ +++++"i _gly + + +"+!+#+%+"+$+#+&j Btyr +#+&+%+'+)+1+&+(+'+&+*+)+++,+*+-+*+.+++/+,+/+-+.+0+/+2k _ser +'+2+1+3+5+7+2+4+3+2+6+5+8l _lys +3+8+7+9+;+@+8+:+9+8+<+;+=+<+>+=+?+>+Am _ser +9+A+@+B+D+F+A+C+B+A+E+D+Gn _lys +B+G+F+H+J+O+G+I+H+G+K+J+L+K+M+L+N+M+Po _leu+H+P+O+Q+S+W+P+R+Q+P+T+S+U+V+T+T+Xp _gly+Q+X+W+Y+[+X+Z+Y+\q Hala +Y+\+[+]+_+`+\+^+]+\+ar Hasn+]+a+`+b+d+h+a+c+b+a+e+d+f+g+e+e+is Hala +b+i+h+j+l+m+i+k+j+i+nt Hile+j+n+m+o+q+u+n+p+o+n+r+s+q+t+q+r+vu Hleu+o+v+u+w+y+}+v+x+w+v+z+y+{+|+z+z+~v Hgly+w+~+}+++~+++w Hval+++++++++++++++x Hser +++++++++++++y Hile+++++++++++++++++z Hala +++++++++++{ Hcys +++++++++++++| Hcys +++++++++++++} Harg +++++++++++++++++++++++~ Hala +++++++++++ Hgly+++++++++ Hala +++++++++++ Hala +++++++++++ Hser +++++++++++++ Hlys +++++++++++++++++++ _gly+++++++++ _leu+++++++++++++++++ _pro+++++++++++++++++ Hleu+++++++++++++++++ Htyr +++++++++++++++++++++++++++ Hlys +++++,++++,+,,,,,,, Htyr +,,,,,,,,,, ,, , , , , , , ,, ,, , ,,, Hile,,,,,,,,,,,,,,,,, Hala ,,,,,,,,,,, Hthr,,,,,!,$,, ,,,",#,!,!,% Hleu,,%,$,&,(,,,%,',&,%,),(,*,+,),),- _ala ,&,-,,,.,0,1,-,/,.,-,2 _gly,.,2,1,3,5,2,4,3,6 _lys ,3,6,5,7,9,>,6,8,7,6,:,9,;,:,<,;,=,<,? _thr,7,?,>,@,B,E,?,A,@,?,C,D,B,B,F _ile,@,F,E,G,I,M,F,H,G,F,J,K,I,L,I,J,N _asp,G,N,M,O,Q,U,N,P,O,N,R,Q,S,T,R,R,V _lys ,O,V,U,W,Y,^,V,X,W,V,Z,Y,[,Z,\,[,],\,_ Emet,W,_,^,`,b,f,_,a,`,_,c,b,d,c,e,d,g Eval,`,g,f,h,j,m,g,i,h,g,k,l,j,j,n Emet,h,n,m,o,q,u,n,p,o,n,r,q,s,r,t,s,v _pro,o,v,{,u,w,y,|,v,x,w,v,z,y,{,u,z,} Eval,w,},|,~,,,},,~,},,,,, Epro,~,,,,,,,,,,,,,,,, Ephe ,,,,,,,,,,,,,,,,,,,,,,,,, Ephe ,,,,,,,,,,,,,,,,,,,,,,,,, Easn,,,,,,,,,,,,,,,,, _val,,,,,,,,,,,,,,, Eile,,,,,,,,,,,,,,,,, Easn,,,,,,,,,,,,,,,,, _gly,,,,,,,,, Ggly,,,,,,,,, Gglu ,,,,,,,,,,,,,,,,,,, Ghis ,,,,,,,,,,,,,,,,,,,,,,, _ala ,,,,,,,,,,, _gly,,,,,,,,, _asn,,,,,,,,,,,,,,,,, _gly,,,,,,,,, _leu,,,,,,,,,,,,,,,,, _ala ,,,,,,,,,,, _leu,,,,--,,,,------- _gln ,----- ----- -- - - - - - - Eglu --- ---------------- Ephe ------!-------------- -- ---" Eleu--"-!-#-%-)-"-$-#-"-&-%-'-(-&-&-* Eile-#-*-)-+---1-*-,-+-*-.-/---0---.-2 Eala -+-2-1-3-5-6-2-4-3-2-7 _pro-3-7-<-6-8-:-=-7-9-8-7-;-:-<-6-;-> _val-8->-=-?-A-D->-@-?->-B-C-A-A-E _gly-?-E-D-F-H-E-G-F-I _ala -F-I-H-J-L-M-I-K-J-I-N _pro-J-N-S-M-O-Q-T-N-P-O-N-R-Q-S-M-R-U _asn-O-U-T-V-X-\-U-W-V-U-Y-X-Z-[-Y-Y-] Hile-V-]-\-^-`-d-]-_-^-]-a-b-`-c-`-a-e Harg -^-e-d-f-h-o-e-g-f-e-i-h-j-i-k-j-l-k-m-n-l-l-p Hglu -f-p-o-q-s-x-p-r-q-p-t-s-u-t-v-w-u-u-y Hala -q-y-x-z-|-}-y-{-z-y-~ Hile-z-~-}----~---~------- Harg ----------------------- Htyr --------------------------- Hgly--------- Hser ------------- Hglu ------------------- Hthr--------------- Htyr --------------------------- Hhis ----------------------- Hhis ----------------------- Hleu----------------- Hlys ------------------- Hasn----------------- Hval--------------- Hile----------------- Hlys ---...-..-......... Hasn.... . ... . .. . . .. . . Hlys . .................. Htyr ......$.......... ..!.."..". .!.#.".% _gly..%.$.&.(.%.'.&.) Gleu.&.).(.*.,.0.).+.*.).-.,.../.-.-.1 Gasp.*.1.0.2.4.8.1.3.2.1.5.4.6.7.5.5.9 Gala .2.9.8.:.<.=.9.;.:.9.> Gthr.:.>.=.?.A.D.>.@.?.>.B.C.A.A.E _asn.?.E.D.F.H.L.E.G.F.E.I.H.J.K.I.I.M Bval.F.M.L.N.P.S.M.O.N.M.Q.R.P.P.T _gly.N.T.S.U.W.T.V.U.X _asp.U.X.W.Y.[._.X.Z.Y.X.\.[.].^.\.\.` _glu .Y.`._.a.c.h.`.b.a.`.d.c.e.d.f.g.e.e.i _gly.a.i.h.j.l.i.k.j.m _gly.j.m.l.n.p.m.o.n.q Bphe .n.q.p.r.t.{.q.s.r.q.u.t.v.w.u.x.u.y.v.z.w.z.x.y.| _ala .r.|.{.}...|.~.}.|. _pro.}................ _asn................. _val............... _ala ........... _thr............... Hala ........... Hglu ................... Hglu ................... Hala ........... Hleu................. Hasn................. Hleu................. Hleu................. Hval............... Hglu ................... Hala ........... Hile................. Hlys ...../...././////// Hala .///// /////  _ala // / / / // / / / / _gly/ //////// _tyr ////////////////////////////! _glu$// //!//"/&//#/'/0/ /$/0/!/%/"/#/ /(/!/)/&/*/'/+/(/,/./)/-///*/+/*/+/1 _gly /"/#/1/0/2/4/1/3/2/5 _lys /2/5/4/6/8/=/5/7/6/5/9/8/:/9/;/:/</;/> _ile/6/>/=/?/A/E/>/@/?/>/B/C/A/D/A/B/F Elys /?/F/E/G/I/N/F/H/G/F/J/I/K/J/L/K/M/L/O Eile/G/O/N/P/R/V/O/Q/P/O/S/T/R/U/R/S/W Eala /P/W/V/X/Z/[/W/Y/X/W/\ Ephe /X/\/[/]/_/f/\/^/]/\/`/_/a/b/`/c/`/d/a/e/b/e/c/d/g Easp/]/g/f/h/j/n/g/i/h/g/k/j/l/m/k/k/o _ala /h/o/n/p/r/s/o/q/p/o/t _ala /p/t/s/u/w/x/t/v/u/t/y Gala /u/y/x/z/|/}/y/{/z/y/~ Gser /z/~/}////~///~/// Gglu /////////////////// Gphe ///////////////////////// Etyr /////////////////////////// Elys /////////////////// _gln /////////////////// _asp///////////////// _glu /////////////////// _lys ///////////////////  Elys ///////////////////  Etyr ///////////////////////////  _asp/////////////////  _leu/////////////////  _asp///////////////// _tyr ////00////00000000000000000  _lys /0 00 0 00 0 0 0 0 0 00 00000 _cys 0 00000000000 _lys 00000 0000000000000! _his 00!0 0"0$0*0!0#0"0!0%0$0&0'0%0(0%0)0&0)0'0(0+ Bleu0"0+0*0,0.020+0-0,0+0/0.00010/0/03 _thr0,030204060903050403070806060: Hgly040:090;0=0:0<0;0> Hglu 0;0>0=0?0A0F0>0@0?0>0B0A0C0B0D0E0C0C0G Hlys 0?0G0F0H0J0O0G0I0H0G0K0J0L0K0M0L0N0M0P Hleu0H0P0O0Q0S0W0P0R0Q0P0T0S0U0V0T0T0X Hlys 0Q0X0W0Y0[0`0X0Z0Y0X0\0[0]0\0^0]0_0^0a  Hglu 0Y0a0`0b0d0i0a0c0b0a0e0d0f0e0g0h0f0f0j! Hval0b0j0i0k0m0p0j0l0k0j0n0o0m0m0q" Htyr 0k0q0p0r0t0|0q0s0r0q0u0t0v0w0u0x0u0y0v0z0w0z0x0y0{0z0}# Hglu 0r0}0|0~000}00~0}000000000$ Hgly0~00000000% Htrp 000000000000000000000000000000000& Hleu00000000000000000' Hlys 0000000000000000000( Hlys 0000000000000000000) _tyr 000000000000000000000000000* _pro00000000000000000+ Bile00000000000000000, _ile00000000000000000- Eser 0000000000000. Eval000000000000000/ Eglu 00000000000000000000 _asp000000000000000001 _pro000000000000000002 _phe 00000100000001010101111113 _asp011111 11111 11 1 1 1 1 4 _gln 11 1 1111 111 1111111115 _asp111111111111111116 _asp11111!1%11 111"1!1#1$1"1"1&7 Hphe 11&1%1'1)101&1(1'1&1*1)1+1,1*1-1*1.1+1/1,1/1-1.118 Hala 1'111012141511131211169 Hser 12161517191;161817161:191<: Hphe 171<1;1=1?1F1<1>1=1<1@1?1A1B1@1C1@1D1A1E1B1E1C1D1G; Hser 1=1G1F1H1J1L1G1I1H1G1K1J1M< Hala 1H1M1L1N1P1Q1M1O1N1M1R= Hphe 1N1R1Q1S1U1\1R1T1S1R1V1U1W1X1V1Y1V1Z1W1[1X1[1Y1Z1]> Hthr1S1]1\1^1`1c1]1_1^1]1a1b1`1`1d? Hlys 1^1d1c1e1g1l1d1f1e1d1h1g1i1h1j1i1k1j1m@ Hasp1e1m1l1n1p1t1m1o1n1m1q1p1r1s1q1q1uA Hval1n1u1t1v1x1{1u1w1v1u1y1z1x1x1|B _gly1v1|1{1}11|1~1}1C _glu 1}111111111111111111D _lys 1111111111111111111E _thr111111111111111F Egln 1111111111111111111G Eval111111111111111H Eile11111111111111111I Egly111111111J _asp11111111111111111K _asp11111111111111111L _ile11111111111111111M _leu11111111111111111N _val111111111111111O _thr111111111111111P _asn11111111111111111Q Hile11111111111111111R Hleu11111111111111111S Harg 11111211111121222222222T Hile12222 2 22222 2 2 2 2 2 2U Hglu 222 2222222222222222V Hlys 2222222222222222222 W Hala 22 22!2#2$2 2"2!2 2%X Hleu2!2%2$2&2(2,2%2'2&2%2)2(2*2+2)2)2-Y Hlys 2&2-2,2.20252-2/2.2-212022212322242326Z _asp2.262527292=262827262:292;2<2:2:2>[ _lys 272>2=2?2A2F2>2@2?2>2B2A2C2B2D2C2E2D2G\ _ala 2?2G2F2H2J2K2G2I2H2G2L] _cys 2H2L2K2M2O2Q2L2N2M2L2P2O2R^ _asn2M2R2Q2S2U2Y2R2T2S2R2V2U2W2X2V2V2Z_ Ecys 2S2Z2Y2[2]2_2Z2\2[2Z2^2]2`` Eleu2[2`2_2a2c2g2`2b2a2`2d2c2e2f2d2d2ha Eleu2a2h2g2i2k2o2h2j2i2h2l2k2m2n2l2l2pb Eleu2i2p2o2q2s2w2p2r2q2p2t2s2u2v2t2t2xc _lys 2q2x2w2y2{22x2z2y2x2|2{2}2|2~2}22~2d Hval2y22222222222222e Hasn22222222222222222f Hgln 2222222222222222222g Hile22222222222222222h _gly222222222i _ser 2222222222222j Hval222222222222222k Hthr222222222222222l Hglu 2222222222222222222m Hala 22222222222n Hile22222222222222222o Hglu 2222222222222222222p Hala 22222222222q Hcys 2222222222222r Hleu22222222222222222s Hleu22222222222222222t Hala 22222222222u Hgln 2222232222222222223v Glys 233333 3333333333333 w Gser 33 3 3 3 33 3 3 3 33 3x _gly3 33333333y _trp 333333!3333333333333333333333 33 333"z Egly33"3!3#3%3"3$3#3&{ Eval3#3&3%3'3)3,3&3(3'3&3*3+3)3)3-| Egln 3'3-3,3.30353-3/3.3-313032313334323236} Eval3.363537393<363837363:3;39393=~ Eser 373=3<3>3@3B3=3?3>3=3A3@3C _his 3>3C3B3D3F3L3C3E3D3C3G3F3H3I3G3J3G3K3H3K3I3J3M _arg 3D3M3L3N3P3W3M3O3N3M3Q3P3R3Q3S3R3T3S3U3V3T3T3X _ser 3N3X3W3Y3[3]3X3Z3Y3X3\3[3^ _gly3Y3^3]3_3a3^3`3_3b _glu 3_3b3a3c3e3j3b3d3c3b3f3e3g3f3h3i3g3g3k _thr3c3k3j3l3n3q3k3m3l3k3o3p3n3n3r _glu 3l3r3q3s3u3z3r3t3s3r3v3u3w3v3x3y3w3w3{ _asp3s3{3z3|3~33{3}3|3{33~33333 _ser 3|333333333333 Hphe 3333333333333333333333333 Hile33333333333333333 Hala 33333333333 Hasp33333333333333333 Hleu33333333333333333 Hval333333333333333 Hval333333333333333 Hgly333333333 _leu33333333333333333 _arg 33333333333333333333333 _cys 3333333333333 _gly333333333 Egln 3333333333333333333 Eile33333333333333333 Elys 3333333333333333333 _ser 3333333333334 _gly343444444 _ser 444444 4444444  _pro44 44 4 4 44 4 4 4 44 44 44 _cys 4 444444444444 _arg 444444!44444444444444 444" Hser 44"4!4#4%4'4"4$4#4"4&4%4( Hglu 4#4(4'4)4+404(4*4)4(4,4+4-4,4.4/4-4-41 Harg 4)414042444;414342414544464547464847494:48484< Hleu424<4;4=4?4C4<4>4=4<4@4?4A4B4@4@4D Hcys 4=4D4C4E4G4I4D4F4E4D4H4G4J Hlys 4E4J4I4K4M4R4J4L4K4J4N4M4O4N4P4O4Q4P4S Htyr 4K4S4R4T4V4^4S4U4T4S4W4V4X4Y4W4Z4W4[4X4\4Y4\4Z4[4]4\4_ Hasn4T4_4^4`4b4f4_4a4`4_4c4b4d4e4c4c4g Hgln 4`4g4f4h4j4o4g4i4h4g4k4j4l4k4m4n4l4l4p Hleu4h4p4o4q4s4w4p4r4q4p4t4s4u4v4t4t4x Hmet4q4x4w4y4{44x4z4y4x4|4{4}4|4~4}4 Harg 4y4444444444444444444444 Hile44444444444444444 Hglu 4444444444444444444 Hglu 4444444444444444444 Hser 4444444444444 Hleu44444444444444444 Ggly444444444 Gala 44444444444 Gasp44444444444444444 Ecys 4444444444444 Eval444444444444444 Etyr 444444444444444444444444444 _ala 44444444444 Ggly444444444 Gglu 4444444444444444444 Gser 4444444444444 _phe 4444444444444444444444445 _arg 454555 55555555555555 555  _his 55 5 5 555 5 5 5 5555555555555 _pro5 5555555555555555 _lys 555555$55555 55!5 5"5!5#5"5% _arg 55%5$5&5(5/5%5'5&5%5)5(5*5)5+5*5,5+5-5.5,5,50 _ser 5&505/515350525150545356 _met565557595=565857565:595;5:5<5;5> _val575>5=5?5A5D5>5@5?5>5B5C5A5A5E _val5?5E5D5F5H5K5E5G5F5E5I5J5H5H5L _ile5F5L5K5M5O5S5L5N5M5L5P5Q5O5R5O5P5T _lys 5M5T5S5U5W5\5T5V5U5T5X5W5Y5X5Z5Y5[5Z5] Easp5U5]5\5^5`5d5]5_5^5]5a5`5b5c5a5a5e Eile5^5e5d5f5h5l5e5g5f5e5i5j5h5k5h5i5m Eval5f5m5l5n5p5s5m5o5n5m5q5r5p5p5t  Eala 5n5t5s5u5w5x5t5v5u5t5y  Earg 5u5y5x5z5|55y5{5z5y5}5|5~5}55~5555555  Eglu 5z555555555555555555  Eile55555555555555555  Eleu55555555555555555 _asp55555555555555555 _ser 5555555555555 _arg 55555555555555555555555 _gly555555555 _asn55555555555555555 Epro55555555555555555 Ethr555555555555555 Eile55555555555555555 Eglu 5555555555555555555 Eval555555555555555 Easp55555555555555555 Eval555555555555555 Eser 5555555555555 Ethr555566555566666 _glu 566666 6666666 66 6 6 6 6  _gly66 6 666 666 Egly666666666 Eval666666666666666  Ephe 666666&66666 66!6"6 6#6 6$6!6%6"6%6#6$6'! Earg 66'6&6(6*616'6)6(6'6+6*6,6+6-6,6.6-6/606.6.62" Eala 6(62616365666264636267# Eala 636766686:6;676968676<$ _val686<6;6=6?6B6<6>6=6<6@6A6?6?6C% _pro6=6C6H6B6D6F6I6C6E6D6C6G6F6H6B6G6J& Bser 6D6J6I6K6M6O6J6L6K6J6N6M6P' _gly6K6P6O6Q6P6R6Q6T+ _gly6T6S6U6W6T6V6U6X, _ile6U6X6W6Y6[6_6X6Z6Y6X6\6]6[6^6[6\6`- _tyr 6Y6`6_6a6c6k6`6b6a6`6d6c6e6f6d6g6d6h6e6i6f6i6g6h6j6i6l. _glu 6a6l6k6m6o6t6l6n6m6l6p6o6q6p6r6s6q6q6u/ _ala 6m6u6t6v6x6y6u6w6v6u6z0 _leu6v6z6y6{6}66z6|6{6z6~6}666~6~61 _glu 6{6666666666666666662 _leu666666666666666663 _arg 666666666666666666666664 _asp666666666666666665 _lys 66666666666666666666 _asp666666666666666667 _pro666666666666666668 _lys 66666666666666666669 _arg 66666666666666666666666: Gtyr 666666666666666666666666666; Gleu66666666666666666< Ggly666666666= _lys 6666666666666666666> _gly666666666? _val666666666666666@ Hleu66667767667777777A Hasn67777 7 77777 7 7 7 7 7 7B Hala 777 77777777C Hval777777777777777D Hglu 777777"777777777 7!777#E Hile77#7"7$7&7*7#7%7$7#7'7(7&7)7&7'7+F Ival7$7+7*7,7.717+7-7,7+7/707.7.72G Iarg 7,727173757<7274737276757776787779787:7;79797=H Igln 737=7<7>7@7E7=7?7>7=7A7@7B7A7C7D7B7B7FI Iglu 7>7F7E7G7I7N7F7H7G7F7J7I7K7J7L7M7K7K7OJ Iile7G7O7N7P7R7V7O7Q7P7O7S7T7R7U7R7S7WK Hlys 7P7W7V7X7Z7_7W7Y7X7W7[7Z7\7[7]7\7^7]7`L Hpro7X7`7e7_7a7c7f7`7b7a7`7d7c7e7_7d7gM Hala 7a7g7f7h7j7k7g7i7h7g7lN Hleu7h7l7k7m7o7s7l7n7m7l7p7o7q7r7p7p7tO _leu7m7t7s7u7w7{7t7v7u7t7x7w7y7z7x7x7|P _gly7u7|7{7}77|7~7}7Q _lys 7}777777777777777777R _asp77777777777777777S _pro77777777777777777T _cys 7777777777777U _asp77777777777777777V Hgln 7777777777777777777W Hlys 7777777777777777777X Hgly777777777Y Hile77777777777777777Z Hasp77777777777777777[ Hmet77777777777777777\ Ileu77777777777777777] Imet77777777777777777^ Ival777777777777777_ Iglu 7777777777777777777` Igln 7777777777777777777a Ileu77778877778888888b Iasp788888 88888 88 8 8 8 8 c _gly88 8 888 888d _thr888888888888888e Elys 888888 8888888888888!f Easn88!8 8"8$8(8!8#8"8!8%8$8&8'8%8%8)g _glu 8"8)8(8*8,818)8+8*8)8-8,8.8-8/808.8.82h _trp 8*828183858?82848382868587888689868:8;878:88898<888=8:8>8;8>8<8=8@i Egly838@8?8A8C8@8B8A8Dj Etyr 8A8D8C8E8G8O8D8F8E8D8H8G8I8J8H8K8H8L8I8M8J8M8K8L8N8M8Pk _ser 8E8P8O8Q8S8U8P8R8Q8P8T8S8Vl _lys 8Q8V8U8W8Y8^8V8X8W8V8Z8Y8[8Z8\8[8]8\8_m _ser 8W8_8^8`8b8d8_8a8`8_8c8b8en _lys 8`8e8d8f8h8m8e8g8f8e8i8h8j8i8k8j8l8k8no _leu8f8n8m8o8q8u8n8p8o8n8r8q8s8t8r8r8vp _gly8o8v8u8w8y8v8x8w8zq Hala 8w8z8y8{8}8~8z8|8{8z8r Hasn8{88~88888888888888s Hala 88888888888t Hile88888888888888888u Hleu88888888888888888v Hgly888888888w Hval888888888888888x Hser 8888888888888y Hile88888888888888888z Hala 88888888888{ Hcys 8888888888888| Hcys 8888888888888} Harg 88888888888888888888888~ Hala 88888888888 Hgly888888888 Hala 88888888888 Hala 88888888888 Hser 8888888888888 _lys 8888888888888888888 _gly888888888 _leu88888888888888888 _pro88989998998999899 Hleu99999 9 99999 9 9 9 9 9 9 Htyr 999 999999999999999999999999 Hlys 999999"999999999 99!9 9# Htyr 99#9"9$9&9.9#9%9$9#9'9&9(9)9'9*9'9+9(9,9)9,9*9+9-9,9/ Hile9$9/9.9092969/91909/93949295929397 Hala 909796989:9;979998979< Hthr989<9;9=9?9B9<9>9=9<9@9A9?9?9C Hleu9=9C9B9D9F9J9C9E9D9C9G9F9H9I9G9G9K Hala 9D9K9J9L9N9O9K9M9L9K9P _gly9L9P9O9Q9S9P9R9Q9T _lys 9Q9T9S9U9W9T9V9U9T9X9W9Y9X9Z9Y9[9Z9] _asp9]9\9^9`9d9]9_9^9]9a9`9b9c9a9a9e _lys 9^9e9d9f9h9m9e9g9f9e9i9h9j9i9k9j9l9k9n Emet9f9n9m9o9q9u9n9p9o9n9r9q9s9r9t9s9v Eval9o9v9u9w9y9|9v9x9w9v9z9{9y9y9} Emet9w9}9|9~999}99~9}9999999 _pro9~9999999999999999 Eval999999999999999 Epro99999999999999999 _phe 9999999999999999999999999 Ephe 9999999999999999999999999 Easn99999999999999999 _val999999999999999 Eile99999999999999999 Easn99999999999999999 _gly999999999 Ggly999999999 Gglu 9999999999999999999 Ghis 99999999999999999999999 _ala 99999999999 _gly999999999 _asn99999999999999999 _gly999999999 _leu999:::9::9::::::: _ala ::::: : :: :::  _leu:: : : ::: :: : ::::::: _gln : :::::::::::::::::: Eglu ::::: :%:::::!: :":!:#:$:":":& Ephe ::&:%:':):0:&:(:':&:*:):+:,:*:-:*:.:+:/:,:/:-:.:1 Eleu:':1:0:2:4:8:1:3:2:1:5:4:6:7:5:5:9 Eile:2:9:8:::<:@:9:;:::9:=:>:<:?:<:=:A Eala :::A:@:B:D:E:A:C:B:A:F _pro:B:F:K:E:G:I:L:F:H:G:F:J:I:K:E:J:M _val:G:M:L:N:P:S:M:O:N:M:Q:R:P:P:T _gly:N:T:S:U:W:T:V:U:X _ala :U:X:W:Y:[:\:X:Z:Y:X:] _pro:Y:]:b:\:^:`:c:]:_:^:]:a:`:b:\:a:d _asn:^:d:c:e:g:k:d:f:e:d:h:g:i:j:h:h:l Hile:e:l:k:m:o:s:l:n:m:l:p:q:o:r:o:p:t Harg :m:t:s:u:w:~:t:v:u:t:x:w:y:x:z:y:{:z:|:}:{:{: Hglu :u::~:::::::::::::::: Hala ::::::::::: Hile::::::::::::::::: Harg ::::::::::::::::::::::: Htyr ::::::::::::::::::::::::::: Hgly::::::::: Hser ::::::::::::: Hglu ::::::::::::::::::: Hthr::::::::::::::: Htyr ::::::::::::::::::::::::::: Hhis ::::::::::::::::::::::: Hhis ::::::::::::::::::::::: Hleu::::::::::::::::: Hlys ::::::::::::::::::: Hasn::::::::::::::::: Hval:::;;;:;;:;;;;; Hile;;;;; ; ;;;;; ; ; ; ; ; ; Hlys ;;; ;;;;;;;;;;;;;;;; Hasn;;;;;;;;;;;;;;;;; Hlys ;;;; ;";';;!; ;;#;";$;#;%;$;&;%;( Htyr ; ;(;';);+;3;(;*;);(;,;+;-;.;,;/;,;0;-;1;.;1;/;0;2;1;4 _gly;);4;3;5;7;4;6;5;8 Gleu;5;8;7;9;;;?;8;:;9;8;<;;;=;>;<;<;@ Gasp;9;@;?;A;C;G;@;B;A;@;D;C;E;F;D;D;H Gala ;A;H;G;I;K;L;H;J;I;H;M Gthr;I;M;L;N;P;S;M;O;N;M;Q;R;P;P;T _asn;N;T;S;U;W;[;T;V;U;T;X;W;Y;Z;X;X;\ Bval;U;\;[;];_;b;\;^;];\;`;a;_;_;c _gly;];c;b;d;f;c;e;d;g _asp;d;g;f;h;j;n;g;i;h;g;k;j;l;m;k;k;o _glu ;h;o;n;p;r;w;o;q;p;o;s;r;t;s;u;v;t;t;x _gly;p;x;w;y;{;x;z;y;| _gly;y;|;{;};;|;~;}; Bphe ;};;;;;;;;;;;;;;;;;;;;;;;; _ala ;;;;;;;;;;; _pro;;;;;;;;;;;;;;;;; _asn;;;;;;;;;;;;;;;;; _val;;;;;;;;;;;;;;; _ala ;;;;;;;;;;; _thr;;;;;;;;;;;;;;; Hala ;;;;;;;;;;; Hglu ;;;;;;;;;;;;;;;;;;; Hglu ;;;;;;;;;;;;;;;;;;; Hala ;;;;;;;;;;; Hleu;;;;;;;;;;;;;;;;; Hasn;;;;;;;;;;;;;;;;; Hleu;;;;;;;;;;;;;;;;; Hleu;;;;;;;;;;;;;;;;; Hval;;;;;;;;;;;;;;; Hglu ;;;;;;;;;;;;;;;;;;; Hala ;;;;<<;<;;< Hile;<<<<< <<<<<<<< <<<  Hlys << < < <<< < < < <<<<<<<<< Hala < <<<<<<<<<< Hala <<<<<<<<<<< _gly<<<<<@===<=@=?=A=B=@=@=D _thr===D=C=E=G=J=D=F=E=D=H=I=G=G=K Hgly=E=K=J=L=N=K=M=L=O Hglu =L=O=N=P=R=W=O=Q=P=O=S=R=T=S=U=V=T=T=X Hlys =P=X=W=Y=[=`=X=Z=Y=X=\=[=]=\=^=]=_=^=a Hleu=Y=a=`=b=d=h=a=c=b=a=e=d=f=g=e=e=i Hlys =b=i=h=j=l=q=i=k=j=i=m=l=n=m=o=n=p=o=r  Hglu =j=r=q=s=u=z=r=t=s=r=v=u=w=v=x=y=w=w={! Hval=s={=z=|=~=={=}=|={===~=~=" Htyr =|==========================# Hglu ===================$ Hgly=========% Htrp =================================& Hleu=================' Hlys ===================( Hlys ===================) _tyr ===========================* _pro=================+ Bile=================, _ile=================- Eser =============. Eval===============/ Eglu ===================0 _asp=====>====>=>>>>>1 _pro=>> >>>> >>>>>>> >>> 2 _phe >> > > >>> > > > >>>>>>>>>>>>>>>3 _asp> >>>>>>>>>>>>>>>>4 _gln >>>>>!>&>> >>>">!>#>">$>%>#>#>'5 _asp>>'>&>(>*>.>'>)>(>'>+>*>,>->+>+>/6 _asp>(>/>.>0>2>6>/>1>0>/>3>2>4>5>3>3>77 Hphe >0>7>6>8>:>A>7>9>8>7>;>:><>=>;>>>;>?><>@>=>@>>>?>B8 Hala >8>B>A>C>E>F>B>D>C>B>G9 Hser >C>G>F>H>J>L>G>I>H>G>K>J>M: Hphe >H>M>L>N>P>W>M>O>N>M>Q>P>R>S>Q>T>Q>U>R>V>S>V>T>U>X; Hser >N>X>W>Y>[>]>X>Z>Y>X>\>[>^< Hala >Y>^>]>_>a>b>^>`>_>^>c= Hphe >_>c>b>d>f>m>c>e>d>c>g>f>h>i>g>j>g>k>h>l>i>l>j>k>n> Hthr>d>n>m>o>q>t>n>p>o>n>r>s>q>q>u? Hlys >o>u>t>v>x>}>u>w>v>u>y>x>z>y>{>z>|>{>~@ Hasp>v>~>}>>>>~>>>~>>>>>>>A Hval>>>>>>>>>>>>>>>B _gly>>>>>>>>>C _glu >>>>>>>>>>>>>>>>>>>D _lys >>>>>>>>>>>>>>>>>>>E _thr>>>>>>>>>>>>>>>F Egln >>>>>>>>>>>>>>>>>>>G Eval>>>>>>>>>>>>>>>H Eile>>>>>>>>>>>>>>>>>I Egly>>>>>>>>>J _asp>>>>>>>>>>>>>>>>>K _asp>>>>>>>>>>>>>>>>>L _ile>>>>>>>>>>>>>>>>>M _leu>>>>>>>>>>>>>>>>>N _val>>>>>>>>>>>>>>>O _thr>>>>>>>>>>>>>>>P _asn>>>>>>>>>>>>>>>>>Q Hile>>>>>?>>>>??>?>??R Hleu>????? ??????? ? ??? S Harg ?? ? ? ??? ?? ? ?????????????T Hile? ????????????????U Hglu ???? ?"?'??!? ??#?"?$?#?%?&?$?$?(V Hlys ? ?(?'?)?+?0?(?*?)?(?,?+?-?,?.?-?/?.?1W Hala ?)?1?0?2?4?5?1?3?2?1?6X Hleu?2?6?5?7?9?=?6?8?7?6?:?9?;?<?:?:?>Y Hlys ?7?>?=???A?F?>?@???>?B?A?C?B?D?C?E?D?GZ Hasp???G?F?H?J?N?G?I?H?G?K?J?L?M?K?K?O[ _lys ?H?O?N?P?R?W?O?Q?P?O?S?R?T?S?U?T?V?U?X\ _ala ?P?X?W?Y?[?\?X?Z?Y?X?]] _cys ?Y?]?\?^?`?b?]?_?^?]?a?`?c^ _asn?^?c?b?d?f?j?c?e?d?c?g?f?h?i?g?g?k_ Ecys ?d?k?j?l?n?p?k?m?l?k?o?n?q` Eleu?l?q?p?r?t?x?q?s?r?q?u?t?v?w?u?u?ya Eleu?r?y?x?z?|??y?{?z?y?}?|?~??}?}?b Eleu?z????????????????c _lys ???????????????????d Hval???????????????e Hasn?????????????????f Hgln ???????????????????g Hile?????????????????h _gly?????????i _ser ?????????????j Hval???????????????k Hthr???????????????l Hglu ???????????????????m Hala ???????????n Hile?????????????????o Hglu ???????????????????p Hala ???????????q Hcys ?????????????r Hleu?????????????????s Hleu?????@????@?@@@@@t Hala ?@@@@@@@@@@ u Hgln @@ @@ @ @@ @ @ @ @ @ @@ @@@@@v Hlys @ @@@@@@@@@@@@@@@@@@w Gser @@@@@@ @@@@@@@!x _gly@@!@ @"@$@!@#@"@%y _trp @"@%@$@&@(@2@%@'@&@%@)@(@*@+@)@,@)@-@.@*@-@+@,@/@+@0@-@1@.@1@/@0@3z Egly@&@3@2@4@6@3@5@4@7{ Eval@4@7@6@8@:@=@7@9@8@7@;@<@:@:@>| Egln @8@>@=@?@A@F@>@@@?@>@B@A@C@B@D@E@C@C@G} Eval@?@G@F@H@J@M@G@I@H@G@K@L@J@J@N~ Eser @H@N@M@O@Q@S@N@P@O@N@R@Q@T _his @O@T@S@U@W@]@T@V@U@T@X@W@Y@Z@X@[@X@\@Y@\@Z@[@^ _arg @U@^@]@_@a@h@^@`@_@^@b@a@c@b@d@c@e@d@f@g@e@e@i _ser @_@i@h@j@l@n@i@k@j@i@m@l@o Bgly@j@o@n@p@r@o@q@p@s _glu @p@s@r@t@v@{@s@u@t@s@w@v@x@w@y@z@x@x@| _thr@t@|@{@}@@@|@~@}@|@@@@@ _glu @}@@@@@@@@@@@@@@@@@@ _asp@@@@@@@@@@@@@@@@@ _ser @@@@@@@@@@@@@ Hphe @@@@@@@@@@@@@@@@@@@@@@@@@ Hile@@@@@@@@@@@@@@@@@ Hala @@@@@@@@@@@ Hasp@@@@@@@@@@@@@@@@@ Hleu@@@@@@@@@@@@@@@@@ Hval@@@@@@@@@@@@@@@ Hval@@@@@@@@@@@@@@@ Hgly@@@@@@@@@ Hleu@@@@@@@@@@@@@@@@@ _arg @@@@@@@@@@@@@@@@@@@@@@@ _cys @@@@@@@@@@@@@ _gly@@@@@@@@@ Egln @@@@@@@@@@@@@@@@@@@ Eile@@@@@A@@@@@@@A@@A Elys @AAAAA AAAAAAAAAAA AA  _ser AA A A AAA A A A AAA _glyA AAAAAAAA _ser AAAAAAAAAAAAA _proAAA AAAA!AAAAAAA AAA" _cys AA"A!A#A%A'A"A$A#A"A&A%A( _arg A#A(A'A)A+A2A(A*A)A(A,A+A-A,A.A-A/A.A0A1A/A/A3 Hser A)A3A2A4A6A8A3A5A4A3A7A6A9 Hglu A4A9A8A:A<AAA9A;A:A9A=A<A>A=A?A@A>A>AB Harg A:ABAAACAEALABADACABAFAEAGAFAHAGAIAHAJAKAIAIAM HleuACAMALANAPATAMAOANAMAQAPARASAQAQAU Hcys ANAUATAVAXAZAUAWAVAUAYAXA[ Hlys AVA[AZA\A^AcA[A]A\A[A_A^A`A_AaA`AbAaAd Htyr A\AdAcAeAgAoAdAfAeAdAhAgAiAjAhAkAhAlAiAmAjAmAkAlAnAmAp HasnAeApAoAqAsAwApArAqApAtAsAuAvAtAtAx Hgln AqAxAwAyA{AAxAzAyAxA|A{A}A|A~AA}A}A HleuAyAAAAAAAAAAAAAAAA HmetAAAAAAAAAAAAAAAAA Harg AAAAAAAAAAAAAAAAAAAAAAA HileAAAAAAAAAAAAAAAAA Hglu AAAAAAAAAAAAAAAAAAA Hglu AAAAAAAAAAAAAAAAAAA Hser AAAAAAAAAAAAA HleuAAAAAAAAAAAAAAAAA GglyAAAAAAAAA Gala AAAAAAAAAAA GaspAAAAAAAAAAAAAAAAA Ecys AAAAAAAAAAAAA EvalAAAAAAAAAAAAAAA Etyr AAAAAAAAAAAAAAAAAAAAAAAAAAA _ala AAAAAAAAAAA GglyAAAAAAAAA Gglu AAAAAAAAAAAAAAAAAAB Gser ABABBBBBBBBBB _phe BBBBB BBBBBB B B B B B B BB BB BB BB _arg BBBBBBBBBBBBBBBBBBBBBBB _his BBBBBB%BBBBB BB!B"B B#B B$B!B$B"B#B& _proBB&B+B%B'B)B,B&B(B'B&B*B)B+B%B*B- _lys B'B-B,B.B0B5B-B/B.B-B1B0B2B1B3B2B4B3B6 _arg B.B6B5B7B9B@B6B8B7B6B:B9B;B:B<B;B=B<B>B?B=B=BA _ser B7BAB@BBBDBFBABCBBBABEBDBG _his BBBGBFBHBJBPBGBIBHBGBKBJBLBMBKBNBKBOBLBOBMBNBQ _his BHBQBPBRBTBZBQBSBRBQBUBTBVBWBUBXBUBYBVBYBWBXB[ _his BRB[BZB\B^B[B]B\B[B_B^B`BaB_BbB_BcB`BcBaBbBe _metBeBdBfBhBlBeBgBfBeBiBhBjBiBkBjBm _valBfBmBlBnBpBsBmBoBnBmBqBrBpBpBt _valBnBtBsBuBwBzBtBvBuBtBxByBwBwB{ _ileBuB{BzB|B~BB{B}B|B{BBB~BB~BB _lys B|BBBBBBBBBBBBBBBBBB EaspBBBBBBBBBBBBBBBBB EileBBBBBBBBBBBBBBBBB EvalBBBBBBBBBBBBBBB  Eala BBBBBBBBBBB  Earg BBBBBBBBBBBBBBBBBBBBBBB  Eglu BBBBBBBBBBBBBBBBBBB  EileBBBBBBBBBBBBBBBBB  EleuBBBBBBBBBBBBBBBBB _aspBBBBBBBBBBBBBBBBB _ser BBBBBBBBBBBBB _arg BBBBBBBBBBBBBBBBBBBBBBB _glyBBBBBBBBB _asnBBBBBBBBBBBBBBBBB EproBBBBBBBBBBBBBBBBB EthrBBBBBBBBBBBBBBB EileBBBCCCBCCBCCCCCCC Eglu CCCCC CCC CCC C C C C CC C C EvalCCCCCCCCCCCCCCC EaspCCCCCCCCCCCCCCCCC EvalCCCC C"C%CC!C CC#C$C"C"C& Eser C C&C%C'C)C+C&C(C'C&C*C)C, EthrC'C,C+C-C/C2C,C.C-C,C0C1C/C/C3 _glu C-C3C2C4C6C;C3C5C4C3C7C6C8C7C9C:C8C8C< _glyC4C<C;C=C?C<C>C=C@ EglyC=C@C?CACCC@CBCACD EvalCACDCCCECGCJCDCFCECDCHCICGCGCK  Ephe CECKCJCLCNCUCKCMCLCKCOCNCPCQCOCRCOCSCPCTCQCTCRCSCV! Earg CLCVCUCWCYC`CVCXCWCVCZCYC[CZC\C[C]C\C^C_C]C]Ca" Eala CWCaC`CbCdCeCaCcCbCaCf# Eala CbCfCeCgCiCjCfChCgCfCk$ _valCgCkCjClCnCqCkCmClCkCoCpCnCnCr% _proClCrCwCqCsCuCxCrCtCsCrCvCuCwCqCvCy& _ser CsCyCxCzC|C~CyC{CzCyC}C|C' _glyCzCC~CCCCCC( _ala CCCCCCCCCCC) _ser CCCCCCCCCCCCC* _thrCCCCCCCCCCCCCCC+ _glyCCCCCCCCC, _ileCCCCCCCCCCCCCCCCC- _tyr CCCCCCCCCCCCCCCCCCCCCCCCCCC. _glu CCCCCCCCCCCCCCCCCCC/ _ala CCCCCCCCCCC0 _leuCCCCCCCCCCCCCCCCC1 _glu CCCCCCCCCCCCCCCCCCC2 _leuCCCCCCCCCCCCCCCCC3 _arg CCCCCCCCCCCCCCCCCCCCCCC4 _aspCCCCCCCCCCCCCCCCC5 _lys CCCCCCCCCCCCCCCCCCC6 _aspCCCCCCCCCCCCCCCCC7 _proCCCCCCCCCCCCCCCCC8 _lys CCCDDDCDDCDDDDDDDDD9 _arg DDDD D DDD D DD D D D DD DDDDDDD: Gtyr D DDDDDDDDDDDDDDDDDDDDDDDDDD; GleuDDDD D"D&DD!D DD#D"D$D%D#D#D'< GglyD D'D&D(D*D'D)D(D+= _lys D(D+D*D,D.D3D+D-D,D+D/D.D0D/D1D0D2D1D4> _glyD,D4D3D5D7D4D6D5D8? _valD5D8D7D9D;D>D8D:D9D8D<D=D;D;D?@ HleuD9D?D>D@DBDFD?DAD@D?DCDBDDDEDCDCDGA HasnD@DGDFDHDJDNDGDIDHDGDKDJDLDMDKDKDOB Hala DHDODNDPDRDSDODQDPDODTC HvalDPDTDSDUDWDZDTDVDUDTDXDYDWDWD[D Hglu DUD[DZD\D^DcD[D]D\D[D_D^D`D_DaDbD`D`DdE HileD\DdDcDeDgDkDdDfDeDdDhDiDgDjDgDhDlF IvalDeDlDkDmDoDrDlDnDmDlDpDqDoDoDsG Iarg DmDsDrDtDvD}DsDuDtDsDwDvDxDwDyDxDzDyD{D|DzDzD~H Igln DtD~D}DDDD~DDD~DDDDDDDDDI Iglu DDDDDDDDDDDDDDDDDDDJ IileDDDDDDDDDDDDDDDDDK Hlys DDDDDDDDDDDDDDDDDDDL HproDDDDDDDDDDDDDDDDDM Hala DDDDDDDDDDDN HleuDDDDDDDDDDDDDDDDDO _leuDDDDDDDDDDDDDDDDDP _glyDDDDDDDDDQ _lys DDDDDDDDDDDDDDDDDDDR _aspDDDDDDDDDDDDDDDDDS _proDDDDDDDDDDDDDDDDDT _cys DDDDDDDDDDDDDU _aspDDDDDDDDDDDDDDDDDV Hgln DDDDDDDDDDDDDDDDDDDW Hlys DDDDDDDDDDDDDDDDDDDX HglyDDDDDDDDDY HileDDDDEEDDDDEEEEEEEZ HaspDEEEEE EEEEE EE E E E E [ HmetEE E EEEE EEE EEEEEEE\ IleuEEEEEEEEEEEEEEEEE] ImetEEEEE E$EEEEE!E E"E!E#E"E%^ IvalEE%E$E&E(E+E%E'E&E%E)E*E(E(E,_ Iglu E&E,E+E-E/E4E,E.E-E,E0E/E1E0E2E3E1E1E5` Igln E-E5E4E6E8E=E5E7E6E5E9E8E:E9E;E<E:E:E>a IleuE6E>E=E?EAEEE>E@E?E>EBEAECEDEBEBEFb IaspE?EFEEEGEIEMEFEHEGEFEJEIEKELEJEJENc _glyEGENEMEOEQENEPEOERd _thrEOEREQESEUEXERETESEREVEWEUEUEYe Elys ESEYEXEZE\EaEYE[EZEYE]E\E^E]E_E^E`E_Ebf EasnEZEbEaEcEeEiEbEdEcEbEfEeEgEhEfEfEjg _glu EcEjEiEkEmErEjElEkEjEnEmEoEnEpEqEoEoEsh _trp EkEsErEtEvEEsEuEtEsEwEvExEyEwEzEwE{E|ExE{EyEzE}EyE~E{EE|EE}E~Ei EglyEtEEEEEEEEj Etyr EEEEEEEEEEEEEEEEEEEEEEEEEEEk _ser EEEEEEEEEEEEEl _lys EEEEEEEEEEEEEEEEEEEm _ser EEEEEEEEEEEEEn _lys EEEEEEEEEEEEEEEEEEEo _leuEEEEEEEEEEEEEEEEEp _glyEEEEEEEEEq Hala EEEEEEEEEEEr HasnEEEEEEEEEEEEEEEEEs Hala EEEEEEEEEEEt HileEEEEEEEEEEEEEEEEEu HleuEEEEEEEEEEEEEEEEEv HglyEEEEEEEEEw HvalEEEEEEEEEEEEEEEx Hser EEEEEEEEEEEEEy HileEEEEEEEEEEEEEEEEEz Hala EEEEEEEEEEE{ Hcys EEEEEFEEEEEEF| Hcys EFFFFFFFFFFFF} Harg FFFFF FFF FFF F F F F F FF FFFFF~ Hala FFFFFFFFFFF HglyFFFFFFFFF Hala FFFFFFFFFFF  Hala FF FF!F#F$F F"F!F F% Hser F!F%F$F&F(F*F%F'F&F%F)F(F+ Hlys F&F+F*F,F.F3F+F-F,F+F/F.F0F/F1F0F2F1F4 _glyF,F4F3F5F7F4F6F5F8 _leuF5F8F7F9F;F?F8F:F9F8F<F;F=F>F<F<F@ _proF9F@FEF?FAFCFFF@FBFAF@FDFCFEF?FDFG HleuFAFGFFFHFJFNFGFIFHFGFKFJFLFMFKFKFO Htyr FHFOFNFPFRFZFOFQFPFOFSFRFTFUFSFVFSFWFTFXFUFXFVFWFYFXF[ Hlys FPF[FZF\F^FcF[F]F\F[F_F^F`F_FaF`FbFaFd Htyr F\FdFcFeFgFoFdFfFeFdFhFgFiFjFhFkFhFlFiFmFjFmFkFlFnFmFp HileFeFpFoFqFsFwFpFrFqFpFtFuFsFvFsFtFx Hala FqFxFwFyF{F|FxFzFyFxF} HthrFyF}F|F~FFF}FF~F}FFFFF HleuF~FFFFFFFFFFFFFFFF _ala FFFFFFFFFFF _glyFFFFFFFFF _lys FFFFFFFFFFFFFFFFFF _aspFFFFFFFFFFFFFFFF _lys FFFFFFFFFFFFFFFFFFF EmetFFFFFFFFFFFFFFFFF EvalFFFFFFFFFFFFFFF EmetFFFFFFFFFFFFFFFFF _proFFFFFFFFFFFFFFFFF EvalFFFFFFFFFFFFFFF EproFFFFFFFFFFFFFFFFF _phe FFFFFFFFFFFFFFFFFFFFFFFFF Ephe FFFFFFFFFFFFFFFFFFFFFFFFF EasnFFFFFFFFFFFFFFFFF _valFFFFFFFFFFFFFFG EileFGFGGGGGGGGGGGGGG EasnGGGG G GGG G GG G G GG G G _glyG GGGGGGGG GglyGGGGGGGGG Gglu GGGGGG GGGGGGGGGGGGG! Ghis GG!G G"G$G*G!G#G"G!G%G$G&G'G%G(G%G)G&G)G'G(G+ _ala G"G+G*G,G.G/G+G-G,G+G0 _glyG,G0G/G1G3G0G2G1G4 _asnG1G4G3G5G7G;G4G6G5G4G8G7G9G:G8G8G< _glyG5G<G;G=G?G<G>G=G@ _leuG=G@G?GAGCGGG@GBGAG@GDGCGEGFGDGDGH _ala GAGHGGGIGKGLGHGJGIGHGM _leuGIGMGLGNGPGTGMGOGNGMGQGPGRGSGQGQGU _gln GNGUGTGVGXG]GUGWGVGUGYGXGZGYG[G\GZGZG^ Eglu GVG^G]G_GaGfG^G`G_G^GbGaGcGbGdGeGcGcGg Ephe G_GgGfGhGjGqGgGiGhGgGkGjGlGmGkGnGkGoGlGpGmGpGnGoGr EleuGhGrGqGsGuGyGrGtGsGrGvGuGwGxGvGvGz EileGsGzGyG{G}GGzG|G{GzG~GG}GG}G~G Eala G{GGGGGGGGGG _proGGGGGGGGGGGGGGGGG _valGGGGGGGGGGGGGGG _glyGGGGGGGGG _ala GGGGGGGGGGG _proGGGGGGGGGGGGGGGGG _asnGGGGGGGGGGGGGGGGG HileGGGGGGGGGGGGGGGGG Harg GGGGGGGGGGGGGGGGGGGGGGG Hglu GGGGGGGGGGGGGGGGGGG Hala GGGGGGGGGGG HileGGGGGGGGGGGGGGGGG Harg GGGGGGGGGGGGGGGGGGGGGGG Htyr GGGGGGGGGGGGGGGGGGGGGGGGGGG HglyGGGGGGGGG Hser GGGGGGGGGGGGG Hglu GGGGGGGGGGGGGGGGGGH HthrGHGHHHHHHHHHHHH Htyr HHHHH HHH HHH H H H H HH HH HH HHHHHH Hhis HHHHHHHHHHHHHHHHHHHHHHH Hhis HHHHH H&HHHHH!H H"H#H!H$H!H%H"H%H#H$H' HleuHH'H&H(H*H.H'H)H(H'H+H*H,H-H+H+H/ Hlys H(H/H.H0H2H7H/H1H0H/H3H2H4H3H5H4H6H5H8 HasnH0H8H7H9H;H?H8H:H9H8H<H;H=H>H<H<H@ HvalH9H@H?HAHCHFH@HBHAH@HDHEHCHCHG HileHAHGHFHHHJHNHGHIHHHGHKHLHJHMHJHKHO Hlys HHHOHNHPHRHWHOHQHPHOHSHRHTHSHUHTHVHUHX HasnHPHXHWHYH[H_HXHZHYHXH\H[H]H^H\H\H` Hlys HYH`H_HaHcHhH`HbHaH`HdHcHeHdHfHeHgHfHi Htyr HaHiHhHjHlHtHiHkHjHiHmHlHnHoHmHpHmHqHnHrHoHrHpHqHsHrHu _glyHjHuHtHvHxHuHwHvHy GleuHvHyHxHzH|HHyH{HzHyH}H|H~HH}H}H GaspHzHHHHHHHHHHHHHHHH Gala HHHHHHHHHHH GthrHHHHHHHHHHHHHHH _asnHHHHHHHHHHHHHHHHH BvalHHHHHHHHHHHHHHH _glyHHHHHHHHH _aspHHHHHHHHHHHHHHHHH _glu HHHHHHHHHHHHHHHHHHH _glyHHHHHHHHH _glyHHHHHHHHH Bphe HHHHHHHHHHHHHHHHHHHHHHHHH _ala HHHHHHHHHHH _proHHHHHHHHHHHHHHHHH _asnHHHHHHHHHHHHHHHHH _valHHHHHHHHHHHHHHH _ala HHHHHHHHHHH _thrHHHHHHHHHHHHHHH Hala HHHHHHHHHHH Hglu HHHHHIHHHHHHHHHHHHI Hglu HIIIII IIIIIIIIIIIII  Hala II I I I II I I I I HleuI IIIIIIIIIIIIIIII HasnIIIIIIIIIIIIIIIII HleuIIII I"I&II!I II#I"I$I%I#I#I' HleuI I'I&I(I*I.I'I)I(I'I+I*I,I-I+I+I/ HvalI(I/I.I0I2I5I/I1I0I/I3I4I2I2I6 Hglu I0I6I5I7I9I>I6I8I7I6I:I9I;I:I<I=I;I;I? Hala I7I?I>I@IBICI?IAI@I?ID HileI@IDICIEIGIKIDIFIEIDIHIIIGIJIGIHIL Hlys IEILIKIMIOITILINIMILIPIOIQIPIRIQISIRIU Hala IMIUITIVIXIYIUIWIVIUIZ Hala IVIZIYI[I]I^IZI\I[IZI_ _glyI[I_I^I`IbI_IaI`Ic _tyr I`IcIbIdIfInIoIcIeIdIcIgIfIhIiIgIjIgIkIhIlIiIlIjIkImIlIq _glu$IdIpIdIqInIrIvIoIsIwIIpItIIqIuIrIsIpIxIqIyIvIzIwI{IxI|I~IyI}IIzI{IzI{I _gly IrIsIIIIIIII _lys IIIIIIIIIIIIIIIIIII _ileIIIIIIIIIIIIIIIII Elys IIIIIIIIIIIIIIIIIII EileIIIIIIIIIIIIIIIII Eala IIIIIIIIIII Ephe IIIIIIIIIIIIIIIIIIIIIIIII EaspIIIIIIIIIIIIIIIII _ala IIIIIIIIIII _ala IIIIIIIIIII Gala IIIIIIIIIII Gser IIIIIIIIIIIII Gglu IIIIIIIIIIIIIIIIIII Gphe IIIIIIIIIIIIIIIIIIIIIIIII Etyr IIIIIIIIIIIIIIIIIIIIIIIIIII Elys IIIIIIIIIIIIIIIIIII _gln IIIIJJIIIIJJJJJJJJJ _aspIJJJJ J JJJJJ J J J J J J _glu JJJ JJJJJJJJJJJJJJJJ _lys JJJJJJJJJJJJJJJJJJJ   Elys JJ JJ!J#J(J J"J!J J$J#J%J$J&J%J'J&J)  Etyr J!J)J(J*J,J4J)J+J*J)J-J,J.J/J-J0J-J1J.J2J/J2J0J1J3J2J5  _aspJ*J5J4J6J8J<J5J7J6J5J9J8J:J;J9J9J=  _leuJ6J=J<J>J@JDJ=J?J>J=JAJ@JBJCJAJAJE  _aspJ>JEJDJFJHJLJEJGJFJEJIJHJJJKJIJIJM _tyr JFJMJLJNJPJXJMJOJNJMJQJPJRJSJQJTJQJUJRJVJSJVJTJUJWJVJY _lys JNJYJXJZJ\JaJYJ[JZJYJ]J\J^J]J_J^J`J_Jb _cys JZJbJaJcJeJbJdJcJbJfJeJh _ser JhJgJiJkJmJhJjJiJhJlJkJn _lys JiJnJmJoJqJvJnJpJoJnJrJqJsJrJtJsJuJtJw _his JoJwJvJxJzJJwJyJxJwJ{JzJ|J}J{J~J{JJ|JJ}J~J BleuJxJJJJJJJJJJJJJJJJ _thrJJJJJJJJJJJJJJJ HglyJJJJJJJJJ Hglu JJJJJJJJJJJJJJJJJJJ Hlys JJJJJJJJJJJJJJJJJJJ HleuJJJJJJJJJJJJJJJJJ Hlys JJJJJJJJJJJJJJJJJJJ  Hglu JJJJJJJJJJJJJJJJJJJ! HvalJJJJJJJJJJJJJJJ" Htyr JJJJJJJJJJJJJJJJJJJJJJJJJJJ# Hglu JJJJJJJJJJJJJJJJJJJ$ HglyJJJJJJJJJ% Htrp JJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ& HleuJJJJJJJJJJJJJJJJJ' Hlys JJJJJJJJJJJJJJJJJJJ( Hlys JJJKKKJKKJKKKKKKKKK) _tyr KKKK K KKK K KK K K KK KK KK KKKKKKKK* _proK KKKKKKKKKKKKKKKK+ BileKKKKKK"KKKKKK KK!KKK#, _ileKK#K"K$K&K*K#K%K$K#K'K(K&K)K&K'K+- Eser K$K+K*K,K.K0K+K-K,K+K/K.K1. EvalK,K1K0K2K4K7K1K3K2K1K5K6K4K4K8/ Eglu K2K8K7K9K;K@K8K:K9K8K<K;K=K<K>K?K=K=KA0 _aspK9KAK@KBKDKHKAKCKBKAKEKDKFKGKEKEKI1 _proKBKIKNKHKJKLKOKIKKKJKIKMKLKNKHKMKP2 _phe KJKPKOKQKSKZKPKRKQKPKTKSKUKVKTKWKTKXKUKYKVKYKWKXK[3 _aspKQK[KZK\K^KbK[K]K\K[K_K^K`KaK_K_Kc4 _gln K\KcKbKdKfKkKcKeKdKcKgKfKhKgKiKjKhKhKl5 _aspKdKlKkKmKoKsKlKnKmKlKpKoKqKrKpKpKt6 _aspKmKtKsKuKwK{KtKvKuKtKxKwKyKzKxKxK|7 Hphe KuK|K{K}KKK|K~K}K|KKKKKKKKKKKKKKK8 Hala K}KKKKKKKKKK9 Hser KKKKKKKKKKKKK: Hphe KKKKKKKKKKKKKKKKKKKKKKKKK; Hser KKKKKKKKKKKKK< Hala KKKKKKKKKKK= Hphe KKKKKKKKKKKKKKKKKKKKKKKKK> HthrKKKKKKKKKKKKKKK? Hlys KKKKKKKKKKKKKKKKKKK@ HaspKKKKKKKKKKKKKKKKKA HvalKKKKKKKKKKKKKKKB _glyKKKKKKKKKC _glu KKKKKKKKKKKKKKKKKKKD _lys KKKKKKKKKKKKKKKKKKKE _thrKKKKKKKKKKKKKKKF Egln KKKKKKKKKKKKKKKKKKKG EvalKKKKKKKKKKKKKKKH EileKKKLLLKLLKLLLLLLLI EglyLLLLL LL LL J _aspLL L L LLL L L L LLLLLLLK _aspL LLLLLLLLLLLLLLLLL _ileLLLLLL"LLLLLL LL!LLL#M _leuLL#L"L$L&L*L#L%L$L#L'L&L(L)L'L'L+N _valL$L+L*L,L.L1L+L-L,L+L/L0L.L.L2O _thrL,L2L1L3L5L8L2L4L3L2L6L7L5L5L9P _asnL3L9L8L:L<L@L9L;L:L9L=L<L>L?L=L=LAQ HileL:LAL@LBLDLHLALCLBLALELFLDLGLDLELIR HleuLBLILHLJLLLPLILKLJLILMLLLNLOLMLMLQS Harg LJLQLPLRLTL[LQLSLRLQLULTLVLULWLVLXLWLYLZLXLXL\T HileLRL\L[L]L_LcL\L^L]L\L`LaL_LbL_L`LdU Hglu L]LdLcLeLgLlLdLfLeLdLhLgLiLhLjLkLiLiLmV Hlys LeLmLlLnLpLuLmLoLnLmLqLpLrLqLsLrLtLsLvW Hala LnLvLuLwLyLzLvLxLwLvL{X HleuLwL{LzL|L~LL{L}L|L{LL~LLLLLY Hlys L|LLLLLLLLLLLLLLLLLLZ _aspLLLLLLLLLLLLLLLLL[ _lys LLLLLLLLLLLLLLLLLLL\ _ala LLLLLLLLLLL] _cys LLLLLLLLLLLLL^ _asnLLLLLLLLLLLLLLLLL_ Ecys LLLLLLLLLLLLL` EleuLLLLLLLLLLLLLLLLLa EleuLLLLLLLLLLLLLLLLLb EleuLLLLLLLLLLLLLLLLLc _lys LLLLLLLLLLLLLLLLLLLd HvalLLLLLLLLLLLLLLLe HasnLLLLLLLLLLLLLLLLLf Hgln LLLLLLLLLLLLLLLLLLLg HileLLLLLLLLLLLLLLLLLh _glyLLLLLLLLLi _ser LLLLLMLLLLLLMj HvalLMMMMMMMMMMMMMMk HthrMMMM M MMM M MM M M M Ml Hglu M MMMMMMMMMMMMMMMMMMm Hala MMMMMMMMMMMn HileMMMMM M$MMMMM!M"M M#M M!M%o Hglu MM%M$M&M(M-M%M'M&M%M)M(M*M)M+M,M*M*M.p Hala M&M.M-M/M1M2M.M0M/M.M3q Hcys M/M3M2M4M6M8M3M5M4M3M7M6M9r HleuM4M9M8M:M<M@M9M;M:M9M=M<M>M?M=M=MAs HleuM:MAM@MBMDMHMAMCMBMAMEMDMFMGMEMEMIt Hala MBMIMHMJMLMMMIMKMJMIMNu Hgln MJMNMMMOMQMVMNMPMOMNMRMQMSMRMTMUMSMSMWv Glys MOMWMVMXMZM_MWMYMXMWM[MZM\M[M]M\M^M]M`w Gser MXM`M_MaMcMeM`MbMaM`MdMcMfx _glyMaMfMeMgMiMfMhMgMjy _trp MgMjMiMkMmMwMjMlMkMjMnMmMoMpMnMqMnMrMsMoMrMpMqMtMpMuMrMvMsMvMtMuMxz EglyMkMxMwMyM{MxMzMyM|{ EvalMyM|M{M}MMM|M~M}M|MMMMM| Egln M}MMMMMMMMMMMMMMMMMM} EvalMMMMMMMMMMMMMMM~ Eser MMMMMMMMMMMMM _his MMMMMMMMMMMMMMMMMMMMMMM _arg MMMMMMMMMMMMMMMMMMMMMMM _ser MMMMMMMMMMMMM _glyMMMMMMMMM _glu MMMMMMMMMMMMMMMMMMM _thrMMMMMMMMMMMMMMM _glu MMMMMMMMMMMMMMMMMMM _aspMMMMMMMMMMMMMMMMM _ser MMMMMMMMMMMMM Hphe MMMMMMMMMMMMMMMMMMMMMMMMM HileMMMMMMMMMMMMMMMMM Hala MMMMMMMMMMM HaspMMMMMMMMMMMMMMMMM HleuMMMNNNMNNMNNNNNNN HvalNNNNN N NN NNN N N N N HvalNNN NNNNNNNNNNNN HglyNNNNNNNNN _leuNNNNNN NNNNNNNNNNN! _arg NN!N N"N$N+N!N#N"N!N%N$N&N%N'N&N(N'N)N*N(N(N, _cys N"N,N+N-N/N1N,N.N-N,N0N/N2 _glyN-N2N1N3N5N2N4N3N6 Egln N3N6N5N7N9N>N6N8N7N6N:N9N;N:N<N=N;N;N? EileN7N?N>N@NBNFN?NAN@N?NCNDNBNENBNCNG Elys N@NGNFNHNJNONGNINHNGNKNJNLNKNMNLNNNMNP _ser NHNPNONQNSNUNPNRNQNPNTNSNV _glyNQNVNUNWNYNVNXNWNZ _ser NWNZNYN[N]N_NZN\N[NZN^N]N` _proN[N`NeN_NaNcNfN`NbNaN`NdNcNeN_NdNg _cys NaNgNfNhNjNlNgNiNhNgNkNjNm _arg NhNmNlNnNpNwNmNoNnNmNqNpNrNqNsNrNtNsNuNvNtNtNx Hser NnNxNwNyN{N}NxNzNyNxN|N{N~ Hglu NyN~N}NNNN~NNN~NNNNNNNNN Harg NNNNNNNNNNNNNNNNNNNNNNN HleuNNNNNNNNNNNNNNNNN Hcys NNNNNNNNNNNNN Hlys NNNNNNNNNNNNNNNNNNN Htyr NNNNNNNNNNNNNNNNNNNNNNNNNNN HasnNNNNNNNNNNNNNNNNN Hgln NNNNNNNNNNNNNNNNNNN HleuNNNNNNNNNNNNNNNNN HmetNNNNNNNNNNNNNNNNN Harg NNNNNNNNNNNNNNNNNNNNNNN HileNNNNNNNNNNNNNNNNN Hglu NNNNNNNNNNNNNNNNNNN Hglu NNNNNNNNNNNNNNNNNNN Hser NNNNNONNNNNNO HleuNOOOOOOOOOOOOOOOO  _glyOO OO O O O O O  _ala O O O OOOO OOO O _aspOOOOOOOOOOOOOOOOO Ecys OOOOOOOOOOOOO  EvalOO OO!O#O&O O"O!O O$O%O#O#O' Etyr O!O'O&O(O*O2O'O)O(O'O+O*O,O-O+O.O+O/O,O0O-O0O.O/O1O0O3 _ala O(O3O2O4O6O7O3O5O4O3O8 GglyO4O8O7O9O;O8O:O9O< Gglu O9O<O;O=O?ODO<O>O=O<O@O?OAO@OBOCOAOAOE Gser O=OEODOFOHOJOEOGOFOEOIOHOK _phe OFOKOJOLONOUOKOMOLOKOOONOPOQOOOROOOSOPOTOQOTOROSOV _arg OLOVOUOWOYO`OVOXOWOVOZOYO[OZO\O[O]O\O^O_O]O]Oa _his OWOaO`ObOdOjOaOcObOaOeOdOfOgOeOhOeOiOfOiOgOhOk _proObOkOpOjOlOnOqOkOmOlOkOoOnOpOjOoOr _lys OlOrOqOsOuOzOrOtOsOrOvOuOwOvOxOwOyOxO{ _arg OsO{OzO|O~OO{O}O|O{OO~OOOOOOOOOOO _ser O|OOOOOOOOOOO ?clO ?so4OOOOOOOOO ?hoh O ?hoh O ?hoh O ?hoh O ?hoh O ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hohO ?hoh O ?hoh!O ?hoh"O ?hoh#O ?hoh$O ?hoh%O ?hoh&O ?hoh'O ?hoh(O ?hoh)O ?hoh*O ?hoh+O ?hoh,O ?hoh-O ?hoh.O ?hoh/O ?hoh0O ?hoh1O ?hoh2O ?hoh3O ?hoh4O ?hoh5O ?hoh6O ?hoh7O ?hoh8O ?hoh9O ?hoh:O ?hoh;O ?hoh<O ?hoh=O ?hoh>O ?hoh?O ?hoh@O ?hohAO ?hohBO ?hohCO ?hohDO ?hohEO ?hohFO ?hohGO ?hohHO ?hohIO ?hohJO ?hohKO ?hohLO  ?hohMO  ?hohNO  ?hohOO  ?hohPO  ?hohQO ?hohRO ?hohSO ?hohTO ?hohUO ?hohVO ?hohWO ?hohXO ?hohYO ?hohZO ?hoh[O ?hoh\O ?hoh]O ?hoh^O ?hoh_O ?hoh`O ?hohaO ?hohbO ?hohcO  ?hohdO! ?hoheO" ?hohfO# ?hohgO$ ?hohhO% ?hohiO& ?hohjO' ?hohkO( ?hohlO) ?hohmO* ?hohnO+ ?hohoO, ?hohpO- ?hohqO. ?hohrO/ ?hohsO0 ?hohtO1 ?hohuO2 ?hohvO3 ?hohwP4 ?hohxP5 ?hohyP6 ?hohzP7 ?hoh{P8 ?hoh|P9 ?hoh}P: ?hoh~P; ?hohP ?hohP  ?hohP  ?hohP  ?hohP  ?hohP  ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP ?hohP  ?hohP! ?hohP" ?hohP# ?hohP$ ?hohP% ?hohP& ?hohP' ?hohP( ?hohP) ?hohP* ?hohP+ ?hohP, ?hohP- ?hohP. ?hohP/ ?hohP0 ?hohP1 ?hohP2 ?hohP3 ?hohP4 ?hohP5 ?hohP6 ?hohP7 ?hohP8 ?hohP9 ?hohP: ?hohP; ?hohP< ?hohP= ?hohP> ?hohP? 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