2t43.6-1h/data/swissprot/ 3M6L.pdbdupa 3L84.pdb`[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Transketolase In Complex With Thiamine Diphosphate, Ribose-5-Phosphate And Calcium Ion[/h3] [p]B.Nocek, M.Makowska-Grzyska, N.Maltseva, A.Joachimiak, W.Anderson, Csgid[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3M6L" target="blank"]3M6L[/a] [small](deposited on 15-MAR-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3L84.pdb3M6L a_3M6LB1  3L843csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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@nݞo-1f 1d)\*+U Z/tFQWRi BD{TW_Z˅>3fFkm&c2<οwwwv2R%٘o߻ppp`wlQ(#)i8Mq;$$,оLZΞC"G.̯ͼ'(/WRa0h15Lj5炾ˆFFl0 ڭTW8͕˪<.]bY:9Epq̓nݼ9~\>|6AA.X~L7?IDATAnU{)(xPshJ)-m<>CZR֦g~v JwxxL{QxyagWSSU]鸬QQ=ر5ӽb7=5Tt2SnP(FDNO/?|>Z\JK2WBc=w/7?plcƤX=y$5>T*wzt: NL,).ކuuNB!&f>fYMv&'Q*泌(!/<o!: ^ѨرLb߾ۿkK ꃣ'B=d2{V݂wh4"13ù^RRG&KfF婭] JT4;S3KKR[a{~c2agwqw|'O71̀O9qbHZ˿m6J]=l&-u0V >ڃ ?f{]o#%RS' ՠV(/ϵ+;{FA$lt3wr߰(՚еk=O=ՍؓH$R \XڦIQΝnEl{W؋]xyu:?Jqq!'qu C{23_'<|>-n- L&FJslYWN}}.uu#/oEFSMp3Iz4;?~:]-HII&PL3xx{M*ACx #W#.KS[G>(-Gkn}6ՑU`߾Ę aIe9Ģ^oK{ٳ1XnMw=t?sddt'"ÿ{굜DF>FI26nwFJCw72!dd|MAAEZmDS^n+Xݕ @)1qQKR7ٲqFcUUDFC ?a-A.̶mGyY` 3yU)SCwG#E܄Zmyy'b_vݞ<zV^L@@wJK0r7]{'βeGjiW7N_eĈ xKud27k2t@91A 2aK&PRRHiiEt =oۈFWrL,B),|l{UgG2{HtP23TOb$X !'#ƍ{ Z%h[O~+1٣R9"1kptkpooO={tﾊ4 8u>ܘw0|ֿȢ}FcRi8t"ՃK<'88xө),FڍFL￿ΝaV]9A_lޞϫ,=r%$܈/yy'5j>2 ɹh'._ {Ʉw6xMsψ[qv@Qgv5Jv+uuE׿IH,!$3"g-1O0*dذae~ƮԩF{ KzXւke1TV`0DL""b8UU9TT{/FoMJʳde5t`'CtD.G"$5u 'OA}9uj Ν), $;~مPQ=b#vv7ٳ?c0PQ !*j-nnP}!8ujsAYp!/8rd#$)&- ې.gKԲc@)mC*u$"vVHx GM_ױ|=}zCٌ%8*U:AA9zrm4) 3 ƍ8__wįA1;):ɩS?>IJO4ETH$ر3RP+FЭl@ٳ>w/_a4PQQJi闗^SS P3zx3uj99Y,\JC;Mc疁Ժw5t4޵kȇjKPٵґҴi֭sprA.wo)20`dҠRBѨ#?c!{`Xǝq0jjjXև*+]yBBRHH=%%A~D*HrF&V*0a"99G肣'99+C)!':zqq7rb |IѨd`: ,MTgÒUMMLL OOO\\\dTVVrHVDgl׮#Ͷm뷌jhxPY_)qv[)죬yIdd.a,wu`ʕV2⩪1K,]|VTFlb0Tme*1lX<l""^-c09ছAWj,[f9U}ɉMJHȪUqqG{ G#.bxz&QX)=DkTJJէXqrrɄ^,ϑӧt3N[RͭPtCK{22̡ }yPRffk͡owpw pt1'0?9iS6F\n.b]w]Y㎟.%,$$LYvƌϚG(iDXC"8={No-m2cwdחҩS/ 3O/:qb']<' D"E"6y@i>"#퉎v"*ʅw?lW}t/p~#GUzlbŬ]!nn]􌦴6ndG*HKZ][ovPb2dhU{֬| `p?$WWXqcKŬp=oSZZ@F.$ E۶Dee&{FUyStذ89yi'DD C&dp쀀T\]H$$I+bc-E|[o*&>~ T-#s?NFSMUU9TF$ %%u 2G9"E Ĉ=f[-/*j.{v]Цp}+AA)"((wJWg ""iH$P\[U$DT "d<1#2DDCJ\CJ2e:j'2eG>}'O2D"O=uD8:Y 0L@D64qMĎo.Ѷ@`h(YC.뤣B jR0qJ6.0iTÎ4yC٤ K \Ҍ,u)binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//13M6LB1>+f >+f g Ajj ZiEGW/Rk֩?ԏU_Z ֫ZEGkT֨5?QDjOR/jZUTARTj#ZU𐐑D"B! I I !!!!!! 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T&*R|)calarSƩ~#2וS3Xfm:\RłaI/Z7uWy2kLz̍~D{# 5Oc` W[[Q[ 0 {krRPf6ݮ[\"0d svD$T%E@ FAP"2Zk RUXR Qa^ 5F22.L1LazS"6aj ^ ¦)JdifMɀ5LMb 5J65wfi|lUn 'P2+)5nMSh0׿6։W=žcAFcՏ~V:'TsI VfTj5JRCL5hM~X  V 4ƘVFVf h ]6)Y!s-eǠ'`R Jz(yQ%䄂@4 q"y(AkHN9kDtUN- fc>6"!n6.JVZQJP",# "d,"$8:@"E"Hd:H"I"T$Yr6%FUVDlnT1PTCQ L~%{ީ~-3wl~}F^>nRҢ!n)a圁BK,eyu;7mM-E("H0+jJ<`{w3yqJ'5mj@[T:NƷ66/{Tnn$9O{oVl܉:~4{ cE!jSءkٮaEZ`@X x̛MHI-̼y^lS6VT`.{F S c")+(H?[(>ܻI&2# ٫mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//13M6LB1>+f >+f g Ajj ZiEGW/Rk֩?ԏU_Z ֫ZEGkT֨5?QDjOR/jZUTARTj#ZU𐐑D"B! I I !!!!!! I I'/R?AQQ?]jM'Zj֫UQQ֭jFU(IjOR֠UWj/֢jOZZQDP_Z!B@B$ $ $$$$$$$$ $ $%mB f*UUUUI$DDHBUUT$I$I$I*A$"""$D """$$I!B!$UUTI$UUI$I$UUUURDDD@RI$I""IUUUU$DDDIUUUU$!BB$$I$I IBI$DDI*DDDUJHHB!$DI$JJʪ%UUUUA$I$UUU$I$I$I$JI$I""""A$D!$H*I"""$HB!I%UUU$I*UURI$I$UUUT%PI$HUUUUIUUUUI"""HB! *$DI*DDI$H$B$DDIJ%UR""$!II$2binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1binding site for residue gol a 2001ac1 +$$ 1<binding site for residue tpp a 5001ac2C1<ubinding site for residue ca a 801ac31<wbinding site for residue edo a 1002ac4SS1<binding site for residue r5p a 701ac5eUp*1<vbinding site for residue po4 a 633ac61<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RESxx1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES//1<3L84 {\ {\I; ERժZP_֢jP jժ$֟֫Z[ZkU jj+Zj/ pbinding site for residue gol a 2001ac1 +$( 1wbinding site for residue gol a 2002ac2M1wbinding site for residue act a 3001ac37;1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1?333333?333333?333333???????@??+3L84AfffL?p}*+3M6LAfff333?p}2?k( k$??S7@ד0@jC?`fʯ?`fʯ?`fʯ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1f0PNG  IHDRc IDATxw|ǿ3W͒*7l1`%$$p ᒃpB 9t0\q-[VVҖi1][%>Qywwy~RG@$ rƐ^+?0Ͻl/[=9 J &vHerz4p4nؑ C @ $7$IL7wg^sz}lߵ @evFG {R9dADi'#K8ֆד#-C_|^?[wlddžI_R;$I"k=B~V _MWBg]fwmU3.fMzs U$q@*l>J FQU]k+Ժ'ͽ T-̲yAyDcl=nM- Wn gO]> !  a%3S FNEhhX,ƧwN0$CQ#@gjK,;? ]G7/e.oh?9mMԷTQW /ɲ$ GtN I°8$p?%/AS~+7s0̛GLgWG$n?#{-'!! s,]tN s+~coui3d$I7'ǻGɊՏ'%eU'{Ee%PbyL5b-ݮ*ѻ'\aVQq9=AL4<.?Z_~/#3$ĔMؿϺLSgK0-H?3x&ԫLC-@ۙ'^a脣mcĔv5f]5=\7\9˰!0DQsa77_L2Rz#{j6/-Řg&ȡ$ٽDOZhH3mDTmQp:?,\|ImGY4mc<=k5^1xŹI14M045FT S´^OT`w/Ϲ=?rvWor}O Ny_X[`[SUˏ)Dnf19#A$n=B(܄)a?z/s#1 ;|W['XBNt|.=՛jwNw)%*!zcYg%@RU5ƺCl_{D|S״Ɩ9dHOˡ(Äs(y<&J>oIhhp]՛-S51dfq2+=l/i-<.~o:A6Lt @BBe0x{"Vǁ ~67v%2 @9BL3 iIFOIp8^9W<`(+X@qZm@TVB"'cNCiA߃B&eHQVqzP ص3[im':W60zT(BcK Uu;S{rqN~YhJOѢRtzp: -l>N 4MC4N:@ s(4*&y0o5-/@`L4s'6#"SUrjq{8\.'dggOW;jJݻDӍᢾ&WI]CTT]%+`l2yx=>@56Mtðmg35'KW~`r4RC<XȞ5Kq/n{o,@Zi@6;IX0Q;'hAȆAEmr0aПm +9qM (-}0mhi(`UdMoCk:3{ҩHlS=F0Dc 6#b9Jp.k~+#3+t;iii&ncOf9{29 YfLwSCE5t]c) H'Hu C ݌:ASh?-ZC7դh1t#9p4przq<[%'6V?CsKy47ш!t.[s\nfI!'A|.c3i.j2@4#i:N7 ,pO(ڀas}QQ -zCgmKzE&&3Ӄ {JW6V@[(D-D{HL3:"/D2Օ$l߽0|Ѷ*%u0 DQ;Z8a߁^s9|2pULf0i؍$9رo~H~X4Mi%3̉'#p8j̡Nݓbv=6F&q=n6V ܑۖ){R됝HLK\ryp檨?^VZkڇCv2e^?~_>M>*BFQAߴ4k5j Ҳ˽Rvjp$CLrzp:l~mc|4vWov1uL'∻IU1T-fHU}%X~HBT U:X0s$gNL t8 2T[Ѭu]ǩځ[67#N%_׿bO&%be y,(jhtQdN[x> ZP(?zkj1-Gh Cgg̚t xtDMW- kgA 5K, Q:@@eZBu(Z’5-ntF741+ #fŝ=y'6p{yQ‘V. rGwXuGU^Yf //h|}e)$B^w#tDfaqu$;0I#YCP0-ۗHdđ` ظ=2GbjRbjgJ,_U k>wW46sC&=-V1hbz/ھcw'`s~Ɍ y9#7~?y'Ȳo~p"ow qat)qk鱞#IO3So"N C#fK544溺t7F,u @]t m$["\ ^!;s'<(uerq8N$a+I=_?\4(m Q._kl(y%Ï$D}G$y/g뮻￿K2gnӲq:\FTqX2y̜>wux|W @$5FUU{ 8~2$%ـ|DyN8M˵o;M7M*bƊ+bJϿI ,L8gLߛ^hK$Y&M/UZ䑭GAT <*i@e\..+A0@o XޓNj|wO)D=Î<ͯ!--XܱȲ ʾmTb8&yO^{cI*wg}7>};O$>#TB} vy߲_\sK3 !u<㶣K#(5ǾWg[qW^f4A^yŔ]p!~{ڸjXk 3g׹v9 0ev">`ؐ'(Ix'\5_\(Cvvp:\u4jof'nIx7Ԟqq1_ce'YDF w?yYT,d 0hlξ݈34+=Q M’©Y`d~<'ip2i|S4͖]%_q=M8'b]*`\3>%$I&͗O^`yk1q$⢩TlN`\+ &s >5s-?;M~+k#7n&jkky3: r=Ity~CLqNPUE0dŊˈqd[ owfZz /?rG|m΅=^YLAZ\!{m./043UuP׼o [hX;Sq~/!x {iI}q@CR|!IDAT{]}n)cX”e1Ed2f*%'{B{랳wӲMoݬvE!KyG'a$;tc l'ǴW]~9O?8Wy<?$b'{y}*ykgϐ{S^@eΔl,6ARI1h@N:bc"Kꛫ] HFa\{9} dG9Ddy-:>30'd.9s{8KcUz:C!N ˗/矮#+/_>@k{=9^-@H0d6Uu ʺ3a[?$m1IizwqT' e^x`3k,>o￿FzC}C_[+7xN;%3 GCrx⑿/n_&VړǏ~^+0 NֶzKBP^Ogm枰{nƍw7騗-[Ƌ/-c}+w=w?Pp"K%==0xr>|3K/o>&Lŋ3'˜8d/GdC;^tEQ^)aԋ^ K fCᩧg5kعs'?YߤD͌#ٵ˜?L/OOU|z>]޾cʕIso'Dyīj?D+(F|Y8qN^f1v}`mf$7@デmkEZD\{۷~+ۓQF%/xtfVzAR{ǺB&y=\YYe6qDV``J2٣RRy5SEuWgx\^4-vt < ?{>.<Xr<!YGLe[!X>L%lݳiG'qQ5 OuV;ڴ+/ڕ<@0f*kqHk{SeKA>|ղdjjRz}7"j׿u e7+Y9R.@8M=q朥}5[R"JX1-:HttCIAq;[n9t^rGYvڋnQxU0]g-۾ZoUd`y)#d+FKR[[{XuoHHp=wz!] :SƝЧI!t*kĔB4N|XLNW=h gdf.07\pT碋.;tC +'w9#d-rrr# 5QۅSn TB#BBeqy*X`ovXu]xᅦGaa!g:bے7f59L5Jck͠# Gy:֬Yúu*]vOo+u@..J5j㫄

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S=HevJ"Q׼Kn!6m"'`~ʶu0{xrœ1_v\LiӍ`W5tDZR9v3G<,#;dF~MtرcB+Ѷ԰u(xid|Te7oPQ$>O,2DgވnM¶麊+t1bVL`9"GS͌qp9=HH膆ň)a|4$m{"A@|}]bIqagf3ܱ{zRҒY]8yƖca*'Ih Z<4]=7W"I29cU '1sIy OzFW}ߒE?Db) gaiOk|{JiU{perͲ!bJ}Q%L4=L!5aH ڙjwX-D~ʚqR{VVח:@SUhMmc|"Migu'rŒ_a'v|^H{2<"o<(O+F|صSޔmk#;c*8nY!x)^7rΟ xgD+p+g?V>t3̑YĤ1e̝rcfDiX>ˆa޴Wg]"0Gv&=!6t ,(cl+t_N}!L"R9 YD٨c`ͦWeHH3kkVkum@M(Anf1Kfb_K6̎0j6z#3S9YVa&>ž.RK -nL AMn+y'#܀"O F<) )0`ȓ€"O F<) )0`ȓ€"O O6=IENDB`move=1000;blend=1000;3M6LE ꪯUUUUUUUUUUUUU?0?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUu ATP_ToORRZT_Z&jH_Uժ jTVHTQRTRR_G֤'Z֩?P_UOQQ'EGA֨?/U_ B!D !BW#?0?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUbinding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//13M6LB1>+f >+f g Ajj ZiEGW/Rk֩?ԏU_Z ֫ZEGkT֨5?QDjOR/jZUTARTj#ZU𐐑D"B! I I !!!!!! I I'/R?AQQ?]jM'Zj֫UQQ֭jFU(IjOR֠UWj/֢jOZZQDP_Z!B@B$ $ $$$$$$$$ $ $%mB f*UUUUI$DDHBUUT$I$I$I*A$"""$D """$$I!B!$UUTI$UUI$I$UUUURDDD@RI$I""IUUUU$DDDIUUUU$!BB$$I$I IBI$DDI*DDDUJHHB!$DI$JJʪ%UUUUA$I$UUU$I$I$I$JI$I""""A$D!$H*I"""$HB!I%UUU$I*UURI$I$UUUT%PI$HUUUUIUUUUI"""HB! *$DI*DDI$H$B$DDIJ%UR""$!II$2binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1binding site for residue gol a 2001ac1 +$$ 1<binding site for residue tpp a 5001ac2C1<ubinding site for residue ca a 801ac31<wbinding site for residue edo a 1002ac4SS1<binding site for residue r5p a 701ac5eUp*1<vbinding site for residue po4 a 633ac61<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RESxx1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES//1<3L84d {\ {\I; ERժZP_֢jP jժ$֟֫Z[ZkU jj+Zj/ pbinding site for residue gol a 2001ac1 +$( 1wbinding site for residue gol a 2002ac2M1wbinding site for residue act a 3001ac37;1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1?333333?333333?333333???????@???}}$??K@߯ @@1F?@y?@y?@y??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2BPNG  IHDRc IDATxw|uSe+BB'D *,'g;;;۝zv= *⡢"z -!$om~&Kz!__>ⲳ3k>-ĜI#u*kc:ٸ닎63~ yL5~Gyuo]@JBd%9> ;>?' Ď|ע*m SAӻڷq]XK]}. v0>CYU G21 Voz 8f `w֑o/}xg $ BKȒ:`X9P=⋰GLsE7tz=apYU#3fO)#fq`8^$#I,k1%=a$DQT\:SxZ9`8Y,?; PP (v:~Fh%R'"lVcm8)rM|#N#.yMWFU4]1k;V̨3ڇ6c-]ʫpctm1#CۮIA@@,8NՏt^ kcOq[5 Mݝh<{hY." ;G'`mKKjT qo?IPã:EvS,بddɂ$64xgspC'&_5Dk]OE! XeC擓1ҝ$'}iֲ.]w`fJԡ,v=]>$!KGPP;;1 Ï9/GT^Թh<(dzOm!%> IQ_ Vj쉗RX] -?r24g"~cZ , y1NgQqQq0}܅{x"% vj*hY(WPOtGe+~]:@=q>nzO W/~ 24:NVgh#,_v<ՓpBǖ$I]\k 3}p} 꽮d 'RE*jJX.Z̑dgtgQygL/$/~)B C3IsWw_;zo B`xu5bwQؘ8ŏAT>\Lv OбH*=MSQ5BڤtӇs:R⳰Y#EdD,zV dQxmKi9#Kbl8"8"xnJJ࿯ig?t0 ~}crjR?<:4ݴT֔>G,TC7tkKIKw~l#NGUU=G.5EA\1Ŝ ӯզ9`=躎n]#̛T{BR\*5a(M$).^MˣwBDQf7>]Pծ \e4A4w+zAe dhD,;V=]m\4п ^v7u(<^wa_H[x^@ ~+/VыrUj ^_Ǫ oc:u4] -Ѝ# CTl?WwJjb6k6HUwJsʘ1G ]x7ZWGqy Owhk/ڌn0މx}nA Mi*^ō$ƦAOj.(5:AAFjKLDĆXABK8ŜWKxG_>4MA7tNOA{h  D,[v Co"Kf,YH@aɎNo4i}6||~7`ޥ ijAUnkhcT d;9==e@`k~e*RAf@,;~5/(dɂAdD,ёL;=W]nlf #ep; {!k{+n12se/}Z4]eKC+yMϝrV=ۥڋ6E6{14]|,/sIiD9"~&<{04w>ٶoSv4}J}ۃރHˤ]⭝n#h1ïz[0 ;vjAa>?lC9px-g5dE.+`5-HEaZЩc0tt]-OGŏW"|ɽjfn̙|Y$|]j#hq9y"bS-m"V; nc.Deadي_abl\65r>ԕ 'm(;=<@|L/b").+ !7 Wl%w"G3~["F al߷Sw-g3 W(gXs~iwO͉j1allVSBLb\t {Cf"˪ѸU¾C9XQxoc<تѵ9$16d$'_E38Cv͒9tDr|{[qjȈؐi[ӮWJ(؏ H7{V>uW!gSZGOs:$fgϺ*DC׉J`b|mN}^_=zK}(9ZMh3~C##|6pWL0t"JaPT>SMtdbhWx|M'>VrLN ON0n9’6[r_10Z5HeUwߜ=FSrde vJb\Sr"VܾZ:~7JJ*qb?%TZ6K\}||#Uېe1kE͝w[>nv;hz;.o>_(2z $%!^I$""aGdTWkuםN?JR:E͎jAS5|~9)TsHldRj/ KE~͛~7.g}w9u: k 1IKns.z;=֟ 8; 楥3[iɘDz%fcؼ{UtVbʔ)2bDBZ,nczq:aʶn^= woDtbRvM]9uܻޖ- ogÆl6sǼ?Ȓ,S[[Ŗv6v<7nC4t]EdE ]MdD,yiח\j]`|&Pv?n.&^{5?' y[jbz'G @M(L \ ʑBDW ]jwIOI* hU*y|%CDqF:>!F̩̑gr͟f@FFaFS6qmtB-5C3U%AXP9֒@i 0@;9+`ŝwNll|X=$f=:^2ϟcp7`*Sa3YpNq8lU6i`WWTו+ǯNV-x D9q#QQDEE> {p_v:G3.lҒ4As}.D(U3U36l_1\s2O<>6m+WbҤl V 0ub4]jq`F 7US8\Zȇ/`4ѵ9{ƍ(j}6'cdi"6*={$ʼ/UR۲C6 [H0D 3jq0 s415xvēT+&sw4{EkB+Lo ƞʚMMïxC)ĝI411މL0dQT?] \ v]' ~1daW3Enۋ}Oj0$eJ)+/5od `g˓ =EQ͍':Z ^C|Lo(7eIB% DF! 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I I'/R?AQQ?]jM'Zj֫UQQ֭jFU(IjOR֠UWj/֢jOZZQDP_Z!B@B$ $ $$$$$$$$ $ $%mB f*UUUUI$DDHBUUT$I$I$I*A$"""$D """$$I!B!$UUTI$UUI$I$UUUURDDD@RI$I""IUUUU$DDDIUUUU$!BB$$I$I IBI$DDI*DDDUJHHB!$DI$JJʪ%UUUUA$I$UUU$I$I$I$JI$I""""A$D!$H*I"""$HB!I%UUU$I*UURI$I$UUUT%PI$HUUUUIUUUUI"""HB! *$DI*DDI$H$B$DDIJ%UR""$!II$2binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1binding site for residue gol a 2001ac1 +$$ 1<binding site for residue tpp a 5001ac2C1<ubinding site for residue ca a 801ac31<wbinding site for residue edo a 1002ac4SS1<binding site for residue r5p a 701ac5eUp*1<vbinding site for residue po4 a 633ac61<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RESxx1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES//1<3L84d {\ {\I; ERժZP_֢jP jժ$֟֫Z[ZkU jj+Zj/ pbinding site for residue gol a 2001ac1 +$( 1wbinding site for residue gol a 2002ac2M1wbinding site for residue act a 3001ac37;1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1?333333?333333?333333???????@???wD[4k Q׵A @]t5pjgqCqfĈa4]Mq85%iEբ\0T,>$a]S#tiΟ6:aG uvFg5ôvaSôv6UC,}5|C9L*{Lj4@}s5:BDc!ͼ"ESXv[Ťye./EQ մv43BE6,|o(^XTSyVuMGPd/9W'R2n]W E:0 KU=nYyBLia:íhZYS6no'eXȲ;;'Sul);dqx~^| ES6n"vSDZ{^ hA -F8Ҏq3zU-뛫 0L#Ƒ(CVp5-21i)*7|8 S#`X 4OuTĦ>O p#UÞV a@\qM,_0 (7t0mynh(>O |V˛tѹ3."NBVjv鄰pl*9s(Λ؂ ¨4ji1;[ih Mu²g,N6ua+-4)ʟ>(7bʊ!+m_²,bjPPEY` gBQXiKMƪF".:VT S[,(xB6ֿS!-EY 2 2!K b $BV?t ΉG 7 e!\7DI3׎\pUY>>O@YȲI$^g\T sJL/#HL`Yee,,DADcz7C%!HH (Jɦ6 ?{$IBeڜɥ ndu͇yx=<IT(/f;Xc&T ee$QE ބGG;𷇑DI%(1&ԩk:z:?>乗+Eբpv 1 pdMKڊMgvh3jՁlLƣ0M 9$ᑽȒ/HПIЗ`w`a" d㜫0&҇v9[2]UT-eYɝfhzΆ3E \֋`.r3 Lë{yxc< <ĿחN@=dQHЗߗnx_#"ه@dN4| L^u^xK[~h4EQC[?~j'=B _jmB'|c˜ڕA(tMIA ;qyQd/o:xԾS"l!j( R^dWM;'D!"H'XU~?3|退(Jt[<|$Q 2H d^"{SI:p bLT5KpˇN<& MxaG]!dYrb!NBNbjMk1MC==|ds($+nJ rʒ6`=C~Sg|d 2&see#upfoEmCd呝^Hvf^'霒)A~U/iL^ߺ7;|3kڤJ8S uP< `kA SVv/A5DQYW$hhn -<_ tObo&a\ ao9ɦ#5ksRxP3sO,,J́N`PiNTuUǶQO]S5p?'PZjl#Уp0S>rf@#`1X򉅌cY 8@vFc7S|]դwOg"N6'Kں؋xSt_Ƕm48^od[9Vn wU\0~zc͘Z6:w&[z}z۷[E[[7HW^Iqx`qݫOgCfpEYH$1aT7!zEձ픏CS[-ir_s=ǖͻy$Y$Ialyþ03`kUu]%\B^^^{n|jӺ~f1O]Qf"ɒ& :qȈ&Q>n>O̴Ǐ NP1-U( Y$.eك{tsg.w-m'> \sYа(=ϡ;;$̊ 8b g_Gٟt T?,KiZX9Jx2?i|PWagƫ9p`73?ysg' 8 $-XpXvijQju,<M'DC%ExtK&PR07>4 ĵ0X9ug.#?{^sESy}P)0 PATf~5~BnnUU Lǂe|% hCH dY>O0)+߁Hgt[%AŇϛF[g[=Uo{,)?U4"]tEylC#pT)Hck3o ~/xw_^b oPJA#kV~AEZ u^C$U4j~o$y#qy)H,yX$ FN9teS5|b?zW~j{ۧy W_k/oBQ|i)ޮʍi~;W[8cDc3K`~H؎= ˦qemXpֲ>R]]MkG=>O7MIۃ6!7/|,:dm9tCy-3 ׏\_FQ<{#+8cǞSr7҉3_njz АcAձ8QIp}м75nxN-)LM݁! 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ι2{VYG$VwG n%7*)[$8yt {1r u]'zikkKDz 5t1 uRfU,(o(Z)Won eSUtM#7sY_RagWd9XM&R)Q9|8*ƺKX|u;#PehvY,Ɩ-[Ʊ=؂#X̞_=e|c%f>:OGZkٴ Ar ^O0ɼМ>n?w[jrg'e9/N7Hr4$ѓ/<DQ1%!;nV˂ '/eKuS"r'0`XE;H̘c9ap[ ȻDb!2DCf;t; 4 $WX6# mFEil,iX>$w[la޼yĠOB xȑXf^0TꚎPSw`qŲ;zd >׼,8buij^ʱxc[U&~nAD̰+Λ@g%)DVC\LL>wKVFnŹ3.D۟jx-hzʹEiP(+avF$:mn:rii@nhZ` f#xs_=֤qs$CרK(m_7ZxΝq-<^e `_44W.`+} #4/:.i"xd$;v&Ng`nB[lˍNj ,SQ0St'.AbZtK^C䥷8yY%D$Ɂ]>IW]x'E"6ǰh$'P/7VbƀBM!< (ʛ(lkM* XT&ksp9w, JLLwqS7̮SEQ2i\<ÈmSmlㆶEabj/ ZǏ@g3>mbMjDXn-?M֊-dǁi5*'y\!RH,{vp؁PSJ~v QC܊TB")SwL.OUbwO rJI d&+37h4sfLq+/CVFiWf9G{\s.A#i;utegIJ.'0tRem2%Hl/-Or'g dN6W̹/pM۟{Fy#p9$$COu~oy"Jh(-s4Ad-0 ‘v|}hdCIvB͈ıEy2l6 O'"{0- 7ȡV1Eiim$4scο~C ?zFaNy%HkZOA9tUр =F9SV" $14]%ildg) @sG#M-'{B7yƤDc!V.jQn~Lӎzp ^ŏ,{LpiUBvP3~oϖ=/ k],)ȲRmDc!6}<]3e%%#V4M&-wȊ7,6qݏ5n+DX7geD2nY ϶I2h(2澱H]׈paZ%t $@x $IfڄżޟY6ZLS4t֮'_{ *NٓWAY[˒D YSC$$te:~_F g;CΝ7a#mw&nn"܇!R4pYxB2D+ 70MyJ٤$vlXm(0quN $U;ؗ3TfZD,u%A&#̉Jjsz+'Q|C%8^QGl1D;wVrk _Hƽ# "β%yތe ;ϼK^G6|]Uk>r Ɠed 8Z4bj|p 7Tܜ\jv x^˖en> lݻi?%V47s >O^AWS2?f:汜@sI]-?eq?,,/Թj/;u`3Zُg e15 L*7豎d'pE"ia괇 v "? xR|LaaU;Db~(苶Fcd9oxʶ,ǓaSWp`Y15F^0naSievvg0BZ͡*l*ڗR<3huu'xP?Ȼ' m,#ԄE8ϩB]bjA?cCs~XE{-ouSU3ڄÅmihƦF3ใJ;^ߓÄH,DLG nadKۈ_Њ 4IENDB`move=1000;blend=1000;3M6LF ꪫUUUUUWUUUUUUUTUUUUUWUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPo Ajj *TToO**?JOZ&jH_JTWU**?խR?Z֪E?I֠OjUSTIQQP_(j UWBBD!BB$$$$WWWf#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTbinding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//13M6LB1>+f >+f g Ajj ZiEGW/Rk֩?ԏU_Z ֫ZEGkT֨5?QDjOR/jZUTARTj#ZU𐐑D"B! I I !!!!!! I I'/R?AQQ?]jM'Zj֫UQQ֭jFU(IjOR֠UWj/֢jOZZQDP_Z!B@B$ $ $$$$$$$$ $ $%mB f*UUUUI$DDHBUUT$I$I$I*A$"""$D """$$I!B!$UUTI$UUI$I$UUUURDDD@RI$I""IUUUU$DDDIUUUU$!BB$$I$I IBI$DDI*DDDUJHHB!$DI$JJʪ%UUUUA$I$UUU$I$I$I$JI$I""""A$D!$H*I"""$HB!I%UUU$I*UURI$I$UUUT%PI$HUUUUIUUUUI"""HB! *$DI*DDI$H$B$DDIJ%UR""$!II$2binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1binding site for residue gol a 2001ac1 +$$ 1<binding site for residue tpp a 5001ac2C1<ubinding site for residue ca a 801ac31<wbinding site for residue edo a 1002ac4SS1<binding site for residue r5p a 701ac5eUp*1<vbinding site for residue po4 a 633ac61<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RESxx1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES//1<3L84d {\ {\I; ERժZP_֢jP jժ$֟֫Z[ZkU jj+Zj/ pbinding site for residue gol a 2001ac1 +$( 1wbinding site for residue gol a 2002ac2M1wbinding site for residue act a 3001ac37;1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1?333333?333333?333333???????@???\\$??`fV;@ ,@@ 'J?Z?Z?Z??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5 "PNG  IHDRc IDATxy|Tg,,j-DnkV\oէVZm\>JZ+* @HBȞY~sNf$lLuɜs~]@ dW %O@ l4@<&O@ l4@<&O@ l4@<&O@ l4@<FOv3ϥ蚁iU}ߚdW'. jžHIUu)U#[]:-O;b@det"TTDZVٓ~FJ8 ]3TUTUU=1k'86aa8u;J`&mb&^jhPF_4iP\z]KQPPTcmK^@eXvˎ`ZU;ētFv %El o9Fiya<ܐY(±_= r#LwG B.޵w,ϥvMhh(Fkϛ]qCdY#\nަk `քI6gwC!JB#lq_-lcD:I?f L+g>aq D1Wa86cc;&m!nE* ))dfeɽOO蹣/NHOc#͗;W4xoa s{ŇvD)(R~sp#KUQQ,:wΦsv6ٝ;w$\zC2RR ۿiƘcIq3[fOfV&ޗ1־>sit#k_,sw^5]70PF -4^̾ԉNtDZZ'OPTT.^G8FCO[[EMUhG B`;aːFǟN(BQQ!EERtǸ1C aBp_ӿ. ܛI2]AZJ)t¡t¡4RBiCiJncmG2 QTTH w] FWuTUZQIAA}Ya, ˲!:vDΉG>- )q^;.J{ӆP2;U8i&^BUT9R.~ ~:WswuPU΄Cit ˊ?$\^Q-Pk5<(hihwc~UR8%d70'2l0,"p|^ueLAU5tB_t`//puTEC\}]VG4M]BCx)%|nS{壏>gaՔXL}x?՞Ϥa:#rWŧ1OC|Ͱڵ+EEErz֪/7o$rhylض8eZXt[quױgϞKػw/={dx-G|Æ1?unkcf7yhi}1O4ebvctޝk7@/_oպ8u?aZR8A`}"`޽ ]cj*/_ުPUn 5ꊴ3ec(p,>(VbŊsJ8j!;I&B.V=|F"wo-u{GXlY '%h$_8~/!h+9 l^+/?EYٓ[on,Yš52<~Ǩ\Aű/;9[pnQ_ՅP~RVVFyy9O>ŏKKDSeE1Z\fk9Ayy9q} 0܍Cqos0!#UQV->O~dNzFii锗/IEy9ҜՊ<`n#̐[rYo~kBt=[T& ]kHrm;!\a1APw]}[oKQQPUiSlղ= Ʉo@A kCRZd+"m7^~-PQ5lo CM@S4PTP9+"1Q2Tj9ܛJɝ0WV\t$֦#ѵ#_'u [|h ]';@CIj1&*I+k!?~oi$/{fTez-[] eH5@Ӽ5~QDyDIB:ofkɫkwtglzw t0bTJ /=ϥ(UByup?C=r7 ~w1eGTڭxVGl }rQR^7Ƕ&pym0m4MYgEuu5wygB(;fCvZv{b„ ɛg{\?w.lG׾ =m˒%K8x p8a@Q*Z8[?}v+"9s1d~_gFY /V}#O6o.{?7w\O̥&5%tTU^= B6l=v7U_nFW_e…<#B\Ҋ򋿱j7΍no}~s)pz=%Mz@QFěwn*g3qZJ'Fj*FbܹK^ňSFl>9|Oɱg"̝v?~;_s r4f̘&YJSI@pVyjR.nUpr;|?_Oj7d#MM2e0uMU4r፥O-O0,]4uif2R0'J[}N 8koOD'i!oy?,Wj KXhӧ'`0.#S;٥0^;vѣ)ah c2N9o-&sXIxhxtG q9\PP'AOνW\# 7De7&0asx'0n?uR:vѼtAC^1}@9e,XP7C}R2 R1-% [ݻAzjn%UX-* bѢEkτbfįbw_-C;3XeYlG8ˀ2vq]n&?msios~A=*UG BF~Ԣ(+lٲk{9z)M}:uw̄?Mc+3z84Pu*Slfƥ1|A7!8lB' 4UuB!2B0gTO?}sIvA^^o2kW~sqft}a G!â^_СCX@LDH Dt,lՄݻfHu004QP`_6~~ wVQߎGUT+?`n&w/c۶ms=q[z5~[ ˢ2b#BSϿo{_"8I;zv?'|#uZf۟;|:f:mcYʵoF%&?gk =1_5 㴼ov֎I9˅ha4MrcdWroP% !Cٝqch[C 6`A%{p"Lx+ќ} +% !UMѶa>Z׽iY~g}- έ(٫oװ>ʕ+c>wK:oV׊ljңXf6x%3KA!}˺@x=EGX!O{:Mp~uD2qh}xԶY,ʒa,KfMrPVYVxwݍ? p+^3S%bD35e[f v}ضIie1FΥ8'rk ~KSRVgE_nB~x r=j\sv^4I NͺQ =dtp}Vk2K`hс:kX“G9<\цY+kީco| GߌҬAGS][0 6~/jg05fux[mE B\ |W[fppdi܎p n*ŦU,\\<7 [X8ز[jR4-~0~u&XIfǸ!WFNPOf7ON-Xi٤VUUhQyh0lЩlql/?W eTT}zֈ#uS@,]JkN.H9rxdgFYI*[&f=inR,!ᛋx[vU`5x*J))+covl2:FgGk#+3Y(Ji *\ƵCttM +[PO@|-ac۶/YMEU)_}#8h̫فÁ;j[x8mBd꾟4&9*&ãx-P]b#Loxly1Qn(4P*2R2h##u,K]QTTEq"pTBuj[ =Q1g]v}kvɮB !b?E_3Zufe1X?jAFWsW=6r\f5#!]=(;(iM^nirL ? ]]c j9Zhl8F4p1 룟)OK(@}eUՔ\HsC90.ۧrlj+ˊkڀ =YO^)زS7֭?0Hr#B ~Q7'!`/}FHIrIR8Jw?Сݺu4M4M^(2OCb9s0'[ =%59JK y`]T]wDax<8ۢsk+'@ѨQ.-%"U4 @&kU`ϛ\o) >bV-}Ӯ4 ߺE$9Y~}x$.&RIuM8^tia#A\o?HXM7Bz?NiO#ի9z4 U5WS$ Q@QTYU1!1ؿ,SZ-z6˳&܅ BF ;/$1o<pUW%tYaGov?].7 EQic펌N B˪AuBB,Ep_)OXv-۶%n@f ۶Wmۨ.C t bVCht=w:||OSamۤ`awNADz!/^x)SPZQDMR(*rv밻㬾tқn1ϙ8r:GH: UBPc4@kS@5f5HƜo"ϱo<.24U Bz w ZonjY˱9?YԺl޽$hyQ\tw5Sug|=H o \4?Fh) -3qUTUs}ϣ"]xAؘV 'a5TTR  2벟a ]~VnusufW"p˞UmR@< #gg^F]uŻNmEAn;xL@hJT) ivFi ]i7nC>R6u#*Ȅpش6w v@H jo駸^u SDe͌̚('9Ae,RNNsēd =7 ;Ks  HsZo HA{$hy~ksV"}:fƩ}'I 7dWVpCt^S-OԋoIDAT:w8GP t`Nw8 "d!t@ =qmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//13M6LB1>+f >+f g Ajj ZiEGW/Rk֩?ԏU_Z ֫ZEGkT֨5?QDjOR/jZUTARTj#ZU𐐑D"B! I I !!!!!! I I'/R?AQQ?]jM'Zj֫UQQ֭jFU(IjOR֠UWj/֢jOZZQDP_Z!B@B$ $ $$$$$$$$ $ $%mB f*UUUUI$DDHBUUT$I$I$I*A$"""$D """$$I!B!$UUTI$UUI$I$UUUURDDD@RI$I""IUUUU$DDDIUUUU$!BB$$I$I IBI$DDI*DDDUJHHB!$DI$JJʪ%UUUUA$I$UUU$I$I$I$JI$I""""A$D!$H*I"""$HB!I%UUU$I*UURI$I$UUUT%PI$HUUUUIUUUUI"""HB! *$DI*DDI$H$B$DDIJ%UR""$!II$2binding site for residue gol a 2001ac1 +$$ 1binding site for residue tpp a 5001ac2C1ubinding site for residue ca a 801ac31wbinding site for residue edo a 1002ac4SS1binding site for residue r5p a 701ac5eUp*1vbinding site for residue po4 a 633ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1binding site for residue gol a 2001ac1 +$$ 1<binding site for residue tpp a 5001ac2C1<ubinding site for residue ca a 801ac31<wbinding site for residue edo a 1002ac4SS1<binding site for residue r5p a 701ac5eUp*1<vbinding site for residue po4 a 633ac61<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RESxx1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES1<met->mse selenomethionine MOD_RES//1<3L84d {\ {\I; ERժZP_֢jP jժ$֟֫Z[ZkU jj+Zj/ pbinding site for residue gol a 2001ac1 +$( 1wbinding site for residue gol a 2002ac2M1wbinding site for residue act a 3001ac37;1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES//1?333333?333333?333333???????@???0K; J?˅6transketolase; chain: a; ec: 2.2.1.1; engineered: yes3M6L3m6lC 1 2 1CBB;???a???@779m ?Phr\=x C;=<;?>@?AB@@D  Hgln <DCEGLDFEDHGIHJKIIM  Hala EMLNPQMONMR  HasnNRQSUYRTSRVUWXVVZ  HthrSZY[]`Z\[Z^_]]a  Hleu[a`bdhacbaedfgeei Harg bihjlsikjimlnmonpoqrppt Hphe jtsuw~tvutxwyzx{x|y}z}{| Hleuu~ Hser  Hala  Hasp Hmse Hval Hgln  Hlys  Hala  _asn _ser  _gly _his  _pro Hgly Hala  Hpro! Hleu" Hgly# Hleu$ Hala     % Hasp      & Hile ' Hleu# !"  $( Hser $#%')$&%$('*) Hval%*)+-0*,+*./--1* Hleu+1024813215467559+ Gser 298:<>9;:9=<?, Gtyr :?>@BJ?A@?CBDECFCGDHEHFGIHK- _his @KJLNTKMLKONPQOROSPSQRU. _leuLUTVX\UWVUYXZ[YY]/ _lys V]\^`e]_^]a`bacbdcf0 _his ^fegiofhgfjikljmjnknlmp1 _asngpoqswprqptsuvttx2 _proqx}wy{~xzyx|{}w|3 _lys y~4 _asn5 _pro6 _thr7 _trp 8 _leu9 _asn: _arg ; _asp< Earg = Eleu> Eval? Ephe @ _ser A _glyB GglyC Ghis       D Gala       E Hser  F Hala G Hleu# !"  $H Hleu$#%'+$&%$(')*((,I Htyr %,+-/7,.-,0/120304152534658J Hser -879;=8:98<;>K Hphe 9>=?AH>@?>BACDBEBFCGDGEFIL Hleu?IHJLPIKJIMLNOMMQM Hhis JQPRTZQSRQUTVWUXUYVYWX[N HleuR[Z\^b[]\[_^`a__cO Hser \cbdfhcedcgfiP _glydihjlikjmQ _tyr jmlnpxmonmqprsqtqurvsvtuwvyR _aspnyxz|y{zy}|~}}S _leuzT _ser U HleuV Hglu W HaspX HleuY Hlys Z Gasn[ _phe \ _arg ] _gln ^ _leu_ _his ` _ser a _lys b _thrc _pro         d _gly e _his f _pro" #! "!$g _glu $#%',$&%$(')(*+))-h _ile%-,.04-/.-1203015i _ser .5468:576598;j _thr6;:<>A;=<;?@>>Bk _leu<BACEIBDCBFEGHFFJl _glyCJIKMJLKNm _valKNMOQTNPONRSQQUn _glu OUTVX]UWVUYXZY[\ZZ^o _ileV^]_ae^`_^bcadabfp _ala _fegijfhgfkq _thrgkjlnqkmlkopnnrr _glylrqsurtsvs _prosv{uwy|vxwvzy{uz}t _leuw}|~}~}u _gly~v Hgln w Hglyx Hvaly Hala z Hasn{ Hala | Hval} Hgly~ Hphe  Hala  Hmse Hala  Hala  Hlys  Hlys  Hala  Hgln  Hasn Hleu     Hleu       _gly  _ser  _asp!% "!#$""& _leu&%')-&('&*)+,**. _ile'.-/15.0/.2314126 _asp/6579=6876:9;<::> _his 7>=?AG>@?>BACDBEBFCFDEH _lys ?HGIKPHJIHLKMLNMONQ EileIQPRTXQSRQUVTWTUY Etyr RYXZ\dY[ZY]\^_]`]a^b_b`acbe Ecys Zedfhjegfeihk Eleufkjlnrkmlkonpqoos Ecys lsrtvxsutswvy Eglytyxz|y{z} Haspz}|~}~} Hgly~ Hasp Hleu Hgln  _glu  Hgly Hile Hser  Htyr  Hglu  Hala  Hcys  Hser  Hleu Hala  Hgly Hleu Hhis  _lys           _leu _asp _asn "&! #"$%##' Ephe  '&(*1')('+*,-+.+/,0-0./2 Eile(213592432675856: Eleu3:9;=A:<;:>=?@>>B Eile;BACEIBDCBFGEHEFJ Etyr CJIKMUJLKJNMOPNQNROSPSQRTSV EaspKVUWY]VXWVZY[\ZZ^ Eser W^]_ac^`_^bad _asn_dcegkdfedhgijhhm _asn elmknpknqxlmonlrmsptvquwrsrsy Eilenyxz|y{zy}~||} Eser z _ile _glu  Egly Easp Gval Ggly Gleu _ala  _phe  _asn _glu  _asn Hval Hlys  Hmse  Harg  Hphe            Hglu   Hala  ! _gln ! "$)!#"!%$&%'(&&* _gly"*)+-*,+. _phe +.-/18.0/.213425263747569 Eglu /98:<A9;:9=<>=?@>>B Eval:BACEHBDCBFGEEI EleuCIHJLPIKJIMLNOMMQ Eser JQPRTVQSRQUTW EileRWVXZ^WYXW[\Z]Z[_ EasnX_^`bf_a`_cbdeccg _gly`gfhjgihk _his hkjlntkmlkonpqorospsqru _asplutvx|uwvuyxz{yy} Htyr v}|~}~} Hglu ~ Hglu  Hile Hasn Hlys  Hala  Hleu Hglu  Hgln  Hala  Hlys  Glys  _ser  _thr _lys  _pro Ecys        Eleu     Eile Eile $!" # !% Eala %$&()%'&%* Elys &*)+-2*,+*.-/.0/103 _thr+3246935437866: _thr4:9;=@:<;:>?==A _ile;A@BDHACBAEFDGDEI _ala BIHJLMIKJIN _lys JNMOQVNPONRQSRTSUTW _glyOWVXZWYX[ _ala X[Z\^_[]\[` Ggly\`_ac`bad Gglu adcegldfedhgihjkiim Gleuemlnptmonmqprsqqu _glu nutvx}uwvuyxzy{|zz~ _glyv~}~ _ser  Ghis  Glys  Gser  _his  _gly _ala  _pro _leu _gly Hglu  Hglu  Hval  Hile  Hlys   Hlys   Hala   Hlys  Hglu            Hgln   Hala  _gly "! # _phe  #"$&-#%$#'&()'*'+(,),*+. _asp$.-/15.0/.2134226 _pro/6;579<6876:9;5:= _asn7=<>@D=?>=A@BCAAE _ile>EDFHLEGFEIJHKHIM _ser FMLNPRMONMQPS _phe NSRTV]SUTSWVXYWZW[X\Y\Z[^ _his T^]_ag^`_^bacdbebfcfdeh _ile_hgikohjihlmknklp _proipuoqsvprqptsuotw Hgln qwvxzwyxw{z|{}~|| Hala x Hser  Hlys   Hile! Harg " Hphe # Hglu $ Gser % Hala & Hval' Hglu ( Hleu) Hgly* Hasp+ Hleu, Hglu - Hglu      . Hala           / Hlys          0 Htrp                                1 Hlys    ! # ( " ! $ # % $ & % ' & )2 Hasp ! ) ( * , 0 ) + * ) - , . / - - 13 Hlys  * 1 0 2 4 9 1 3 2 1 5 4 6 5 7 6 8 7 :4 Hleu 2 : 9 ; = A : < ; : > = ? @ > > B5 Hglu  ; B A C E J B D C B F E G F H I G G K6 _lys  C K J L N S K M L K O N P O Q P R Q T7 _ser L T S U W Y T V U T X W Z8 _ala U Z Y [ ] ^ Z \ [ Z _9 _lys  [ _ ^ ` b g _ a ` _ c b d c e d f e h: Hlys  ` h g i k p h j i h l k m l n m o n q; Hglu  i q p r t y q s r q u t v u w x v v z< Hleu r z y { } z | { z ~ }  ~ ~ = Hleu { > Hglu  ? Harg  @ Hleu A Hleu B _asn C _pro D _asp E _phe  F _asn G _lys  H _ile I _ala J _tyr  K _pro L _asp               M _phe               N _lys                   O _gly        !P _lys   ! " $ ) ! # " ! % $ & % ' & ( ' *Q _asp " * ) + - 1 * , + * . - / 0 . . 2R Bleu + 2 1 3 5 9 2 4 3 2 6 5 7 8 6 6 :S _ala 3 : 9 ; = > : < ; : ?T Hthr ; ? > @ B E ? A @ ? C D B B FU Harg  @ F E G I P F H G F J I K J L K M L N O M M QV Hasp G Q P R T X Q S R Q U T V W U U YW Hser R Y X Z \ ^ Y [ Z Y ] \ _X Hasn Z _ ^ ` b f _ a ` _ c b d e c c gY Hgly ` g f h j g i h kZ Hglu  h k j l n s k m l k o n p o q r p p t[ Hile l t s u w { t v u t x y w z w x |\ Hleu u | { }  | ~ } |  ] Hasn } ^ Hval _ Hleu ` Hala a Hlys  b Hasn c _leu d _glu  e _gly f Ephe  g Eleu h Egly i Egly j Eser k _ala l _asp m _leu n Hgly o Hpro           p Hser             q Hasn                r _lys                   !s _thr  ! 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C @ D A D B C F Eleu < F E G I M F H G F J I K L J J N Epro G N S M O Q T N P O N R Q S M R U Ephe  O U T V X _ U W V U Y X Z [ Y \ Y ] Z ^ [ ^ \ ] ` Eser V ` _ a c e ` b a ` d c f Eala a f e g i j f h g f k Ethr g k j l n q k m l k o p n n r Ephe  l r q s u | r t s r v u w x v y v z w { x { y z } Gphe  s } | ~ }  ~ }  Gile ~  Gphe   Gser  Gglu   Gtyr   _leu  Hlys   Hpro  Hala  Hala  Harg   Hile  Hala  Hala  Hleu  Hmse        _lys            _ile                 _lys                     _his     " (  !  # " $ % # & # ' $ ' % & ) Ephe  ) ( * , 3 ) + * ) - , . / - 0 - 1 . 2 / 2 0 1 4 Ephe  * 4 3 5 7 > 4 6 5 4 8 7 9 : 8 ; 8 < 9 = : = ; < ? Eile 5 ? > @ B F ? A @ ? 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                             f                         f f f                    f f f f f f f f f f f f     f                 f f f        f f f f f f f f f f f f f f f f f f f f f f f f f f                       f  f f f f f                          f f f f        f    f f   f    f f f    B      f f       f f               f f f f       f f f f f f      f      f f f f              f f f f f f f f f                              f           f f f f f f f f f f f f f f f f                  f f      f f    B   f f f f f f f f f f f f f    f f f                 f f        f f                 f f f      f f      f f      f f          f f f    f f f                f f f     f f f f f f f f f  f f f f f      f     f f f f f f      f f f                f f f      f f        f          f f      f f f f        f f    f f f f f f f f f          f f           f f $binding site for residue gol a 2001 +ac10F!"$binding site for residue gol a 2001$$ac1F$binding site for residue tpp a 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