; 3.6-1h/data/swissprot/ 3R7T.pdbdupa 1ADE.pdb3[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Adenylosuccinate Synthetase From Campylobacter Jejuni[/h3] [p]Y.Kim, M.Gu, K.Kwon, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3R7T" target="blank"]3R7T[/a] [small](deposited on 23-MAR-11)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1ADE.pdb3R7T a_3R7TB1  1ADE3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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Omse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1?333333?333333?333333???????@???Ć$??CS Y8@?`jJ?`jJ?`jJ??@@@x@x@ ???333333?333333???#~j????333333? 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B]]9K5cxҳ9ryUSP!x/(.NBEii6&!8Ewe^߰k?q`Ӧ j5ŻwFI`%ڕbg׃B!`l(B=z$5ux!0p$'hSQqȥZMXqqTT4q}GrB.g5k+ӧaO-FנUg|ˤI5I/[1JCCY :{v5Y9td.f F# s0[G$!~iJJJ "}gaKN{7@~&S*PDZco%%[I; !+9_zGymK9CnqHJ:Od(ڡPWNYElؾI&ѭ[wzˢu>x"">| m(S^[Nh~}VGnQdem``L/خy9L&- '~~# :4o%C.o\ɴiU,/ԣx#$c&{]s@Nt#;f__^5mL#0] Mqgϝ##ñT]C` GnE:,(;o({pe(*6.D%%-Nr;B 4F.wAPO8k}ѲW8yб`kxBCYYmlc 8ָ|{<).Nqqdo\| JΝJ㇙={q`W'4>v~Xٳ0jԍl\ƿ  h4j/OPP>C,R\BYY9C%G㫯޼Lj!rsh1{||XߋyFSDMMqKXN!lno`W^\_ۉ6/Gmׄ$ͪn?= ċn;6֯Ƣhk?ORR"(ֿ7nY7$ٺ?- +2V{ TW7|L`3'gѢ$~pNh2a«M)2;EGwl"uVluWd2+%9rEQl6+Ǭ71}BƏ.eyK`ТՖQ] t괉:5r+ y݇ɓwVwqG{TN؎LjÆ_9|q:tЙtx~~[c}\S_x D\?+$k,̙?:t!c>ĉ/3nlڵ@EuGڎ|}\܆ڊ Yg۹}yC>(e(P(yx< 4eexz֑ Lk֮ LF&QK/-GVW X+YYdeY΃QYD=Fy~%RjwpHee(.v\=Adҳ}syKKm-Sz,$t:R?s).N.W\m/;{6?orT*VHii5ee&DQ䩧>W.1@j+K[lC g:Wer``pX\ItyիW3wΜ'gPQe^u*X(B@.WңoÇyV+ɠ\ #fnk{'&~U(;<@DhR #II졢b]dr|_m;흟Tz"YbAFb\z<1uT"wW,h:@`}=TMrr˗Gf$ d2wqBFkJ&C)$a$L,??n>۴ݯ5;ofЗ#iG|ޥ;Dzg <~u rAL& :@vvu눊qTUUa46Q(\شYbbGFG/GDž 9 H8{:DiufcM3Wy&9I_[BSu{> .mHH/߃O>.'"֧$c<֭C(.\[_!0  &Sd&<))5X2HtE]W!+FlɤlSP$.||iDii 55U|]l[oq㍖㣨^Ν{Êl`b L\rQ/N^w\`Ofe9vnE6 J5#F4Nm0DY&*+w!V[V[vȩD?~, h R)7\.ov6v_?ld..H X<x8|Je|we-Nkw*T*WJW&O6 TW= obF % }Ef$I"/}-[K bsܞ|2+F56v؏[V[ByN**/o 0U lgd'm$Je iiIK;Lnn3g>AVV5vZQ -#{,XB#G~z$$|x81/Zgĉ߈eōGw>Wszz"glŝs?Is~utrtrus\r߾{1LFEc͘."#Ep~c1Q}a )i k4hY>?ee ]5N iI^oQi4Zzl!>\\|Q\5j-jaz\It4 SYyo~e}{1b;v8߹sC zNh0h0va2Z- DAK^}gS]}[o:wrs$7K:vқ6吤u99{ܹq+f4!"H]gt  1$~*?3iWeÿs嗿J0_\As71LhZ :w*эVpÃǕ5\8~Wp %(Yq( #R"%f6Aj%w~4PX":!2ߦvLuphCA'hSS$筠4hy?SVGe(C8ݪ뮺كB*SM*j=<=c=#PҮ6YaJVl&46΅)@$91FNe%J(:c,L)6L2(~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1?333333?333333?333333???????@???*"$=?@;7RS@?۠?۠???@@@x@x@ ???333333?333333???#~j????333333? 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[yx2fS9#gɐQlW v{iKD*a ]> $tʼn' VTGC5"-y!@vp/);Vq?*nW?M]Cݦ)84egbKs97ky̌mx#CƱާ  m*t$?XN12ԡ>Z;ꨞդnc~_iD< E~]VlQC%D<0@g(=:"l l6N|_LF6GOXl$SNMA*~QQņ u8n.Nj=:iSҰN g9dW+ldnWO2BשMC~[W>Yh_ˏ*{ˉ_۰"3 $QhIGPci,h8W,h*$ٚhvL̀St*g=)d_*UENt .bq7DbcGH_H^ /C\-4egNr;pKOEԙ@lYv睲C6 ށRx~qPNaTçhn}D8y)Q3G%T]\9dfҡ8ɚX|j[ĩtu AyqxΠ8CԈ9Ç>ZQE_kN>_l܆ oiw,WS*/D(aUf$yۍ""m]!t'RC!Ρ HĄb#g[@1*SmjKj&KMk.9$}y痉䄡(bHdfWaƳ?{%eȄP0}Z>hBZݜS.]OL2^uyUȉQxmJD88pd}Quf‹v r;P.i/b3zë.nE],)LcRW]%ikv:hLջ;}X7Վ]8qaک_f]0JVWӗ2;S3肠QT2hϡ{j홖X6^}e$of54 cPBm)((5 aYdjRt ш @,!@b%(!K- ch%q)BKv/49ݐO^Kfej릛҈}$m.ɔ P#:xP !Ç #8% a|: t`&Dѱшf/' :eK y=G_^3|cw-skv]٫ioncDӛα.4,w6v5$wɩu~$1wPa>fҔJhWqWA ƥ[ b20sVr#V]KDIAb*0<& :]yDV\6B-;7 if{ZZ!(0NUJ9m/U&eam3&OH\MVeK"aDx<&SFGGĤ-5/$Fꉣ*B B@` Zfm >Tب`&MKZWiE3!Vbe3#֬qMM2$I 2?Nc&#>U|\MrS$1tˋ[<`ݾ_]|/9,n$DpQ_VgjlKEi`n֨oV.]@:XB - .Q9,!%g]@C! ^h%o]5I"M?*IiWhף}]ig]y@V*H9ÔYrOw>iYhhjm4ꢫmɖjkmikMq(Ia`F C)y).<F.K)e&,SJc8ؕ)BQ)oZ%b38-HLK>m1⻿PqEbIlBQ,6C.Q^((Ks䦹چtֵT~qyEİϋK !uFz*Zܛ8-9[R=ct˳GowY\kl]&l7گ親o{1Gd3ܼۡ]gXp,& BդJ-[2&ڒOlIU#V*Fz|ΠjlU(Q GeH1pL ʨB6c}t#ˁj1+ ~ki$9:iHUedG\W;PbOQ?jd[X*!e᷃`t7mN5LvԸl 5.% BA(@8⦪TKi'N/?]4U~;'֤LLErU,,WQOYYd&!jzLuoY .ŘGK G}}[N+ꪉFB }W{S\ʵ[,028ը~6kb1Q0lR tqR(°/aP8eÇ)@82DRBxuLFbb$J87#r#}ΰA=nF3m,D@6B&X/ B@j%{ @4 Ą`x@Vk*J&^kUkfrI;-Ԙ*%@j)s{B0o!^`rvLO/{}v4kLk7)qɤuU[M[lMQ Gmx鞸/4U[:1hLChȅ#@fA0PVED$BBDGF|sϟ*Ll^yE PxH$!N(>č hM"PO6DR.2tS$"sdHR0gJ@d99!!1))9q NLJHTxH0!6tFe%R(&RB3## TFDaV@)m BbP:0m1DU>v&9ɨظfmUBa˒ě+u 2֫'Hܶ]b t?k2e lP2a]]x]^&u164, Ļ,óH$@6Fl `*/'H-'8p^8NJNN" FDd'T6|&6l W@F3jHlsŋmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE'',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@??+1ADEAfffL?p}4+3R7TAfff333?p}-?yy$??SGQ<?UӰ?UӰ?UӰ??@@@x@x@ ???333333?333333???#~j????333333? 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-qrna99n;I704y9.֬Y$BSa kƵҨ*x.$-a9CPQrN I?{M$/WSԈA<#2&ym!`2{" ]w/Rcill)(** ~_Ts}|")tۨ/% n*L{ȊD6IEǏ('k8TUik֤=JlXQdՏ~뭷x7YAhn@jk|R5&}u+nt F 7-mdr/Nn*V=w6 Yq;R30M6A@uE_dDU]1嵅g׫$>هȨ~#lK{lI,($r`J;it'~ΝZf1:ׯG$nf͚S\8\M~| UUYn Fà7"(OUb, ׄ@U|cd f[PdԤ bQ\Ao屷!h5Q[mvmryx״χAs>ً*fdE:s<.fQ~7׎A$~l/!VK<^E~J\5\<& 3WSTU'yAUP)|5z\"Ųb4XxaG@iQR3%}raůN+ wV`h~#ZJn*k@:C> ϱ..7Fߎ~#FcZ1vR2TR~պm6.>̽n)\jn;_O `g44Wt0#[{(LeehVò t#\4+v@zV.JN7eۇ| hUdN̾ UUpX8p{ȊO Yia͢H$MZTU9;#2dϦ$Njy?"q4kqy|oi}JKC3?IF)5_Q 4kQTI>F5k چa9yv"&{ ͎z^>^(ȊWf :ځeY %qf1I6ڪ.\q444d0v#7[9\(:+0tv5O-OqQz+t5YӑS^COel#ΚBr|{n=O* Td"fYuVs<((٥ydm\="ݥ\Y^͎:5y1Dvghbaj^sB՜), !QK&30Z((Ce]1]ٽԻ!s9VT6Y }mxՁ>?q^ s4kMBtX̱Lͽ0|;la60g*rMVS1bD*Jz?7W95@ۿ /̻5g6 K;o0*{/;~HA*kc1q5];eud OUUE!)&F[5u'.Mj^{Џ)=^yE~DSXF]cW,?|b;UG9R"s3˙)P; K0!Hѿ5  @e :*(>(haɫq0 F!%q -XS=jlKGӱp|#XW8ZII cÿ;/) Iب+(AlL"*5 0\CakO[DaieT?Q#xWȚuڎ0!g>qD./1  HO4rDvwQP'Ĉd3:g,0 ܵ&N{n<=ZĪd+D{toySlݲ%(.Rnai^pRe&yML]YeF-RghGYuDQ ?myo%_7|;V?ycromZ#tERQ-=Kg^~ E?yA9끮} ֒,([C'bL=?t>U@[^-xp~DcdNnߪ.! ^ ϳE'/MU]Q㈘<}৆ʖ]j߻:1 >Hю{a$I҉侁cv ХXӮLuda$٫iKu]x&dhEA6n./瓯-'ޱ!@|"mx}nK $ꬪPȚG^ˣ,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???pp$???AW=Z=`;1?g?g?g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2Z'PNG  IHDRc IDATxw3w{pwpы)*D0$ K$UXIFM:wpk[gcvnno<-|vuwAa tb]b61xbML<1&&aO'F#lb61x.dOffL<GOD~=FG1\bh MW?jY4-݄6DZlݽIX4MzV)q{,_͉QR/,MvV)y{8SpҳT:Js[ImuW4IͭR<O}Mn!J/jn[Im@zV<nԹW#JMA:[u"6Z<s+ ,SK>A@'7Q1ʔgI@UHJHe@8rli馵jJiFB߾dds4wWT{0>w"ޜ_tB/=V()bq 1g'-ݴVKIY>!{tzxޞhcN3IoGvݱ(UucwV]!ZHLhGAT~TR҄y靑MQ L瓯^6'0$$IBU<'eIthם.3YSpN?-大:IIITVVr9ZS53非]M ih܅koؽ{7U~X(®C6U[>p1Ζo 63橋|JRFRϊ/ؼi+RLxɆ͵/Ǥ4ŧ4)%eHDN:i?r&hk2o>o~r&7vg9S{d{ϳYS;hıHTK8ƣVmpBΝ#`0ͽ{{߿lh؉$[*n_%њB"8z:: GPK8kwHuy,Z7x P8OLbF5Tm̤хcGEU4M%gAo[cǎ!zH غ]MSt} mXnW_}uK71b hT4̓ vMlO4ƧzKrr\7ZUQ]=NpD}%|;i="[mydE-y^}U{Nx2j0x/\2=K/D^^VBcL {M6~(k>؞϶rJo^/>| 'R.)9~V"Xdqu۷]xY3~<ہmonC=(jd?öm\vep`Ձc4 Zݶ$3-+vzmٲ{5k x336^ie4MG5IIiGRb>s Ƨ/:CL#>RD5`6_G޶{^YdNKfol"#1,8[&)m͉g܇QdB$ $YFY*N#?|_&yk֬f1ql}d16t4h Y n4ӦsÕ$#I#,p:|+0:Ν;ټy3?[lãu6sWo\3.,x&ܤUe]oqLcy~>WfժU|-"$©+;=M<܈k躊貌&$LȒ_giiwOD:=iN-Z6U}3gr>le=7I$Ye EQ?qqql6l6f>bbb6Y1(E1u<D~Sek> KW?*B(=Ock_/=u[mfmIeYRe+CD>L /Dl6 l $$$PVVFaQ!pq88vnP5=1PdC&,h`RD zçv4x^޶&Ō@] \B9)B%g  VF@7CN}0+fłdbjIk%lEՐEcEG@ dY4@^@FH^@/4`>7H,aozϗ[Zl%aO&1 ][s_J6f1F5y`[ذzG]<݋d6H{{M߬[d? J8O+(P*@*ޗw˅ѣ{䖡<ȇ5FM$cO!)!d[/x!tm!ؿ!:}޶R]Dus͔0( E1q>4M[kyWQ_7_֓@yyEEEQTTapt:p8ޱkgs0|x:3D^3ILH%ցd[{R`OAVYRtֹȸ]uGLr}UґJox#j3YT õcǾ"zGQLx<.䙦Yہ@}a {gd{әԤ.$sNy[iеc5S{a׫p0JD -F,&.C*]k=&҇"IvH6wV+95>#qyd @{!d+opx> l b KNɩ|gĿ&]qxq2~\V}p]Uh |i]>2~/ٳׯ#G$++ UU>}:~?pߠ}p$ubC^dAn6y-UK]~a}}/:^}U,Y[4 1\R6zs@qLX m2n!99gf͗rV (1`oRm 1@Ϻux睪-_PfٲeMB^;sYK1Ȋ=7VxZ,KH\myJp:@mAݛ/ IV'l8Iu&O̸q X2>O>INN&~ѯ_?l63f̨]wϟˋ,KIaֳϲ;ų~{?y`ߵIl޼Srt뵎_=v$oZ/2۶=˸qp-Y;w}7w}7V?rf͢K.ۗfy]^ '''L%%zLVoCH T9IslYu[cΤY 2}W9rY׿0K/ҥKի?Ygc3gdw|f`|\ρ? le:406d?Iu?ȊBt (S-T"z7Y揼1u:u*f,{9n=|V+Vo[Peore]!!zvrL67`^`gs9qfO| ΠAꪫ8;`꣭UV,~BII K-[-͛7_I87^`v%$9,@y\0,s4quWUW?}Ń}ূn2Ϫ=W\q `Ĉ!,[_|1ABv>Ջ+qVsQU7ͅ]kL=fOQnp`4U54io+hπ3-'l`x#φra?GåK56|ti*͍UbuUϵYemxo<] SfMIH^;\l)wzddY1$! IBdz,w7z%Pw=ϼY|JBNVp،w)1*C%phZĹFM<^->j_2j ;3$ If_v[宿~ިQT($(<= dq}&Y=Wߪif @7uo9H| Q&:.X'hT%hB|Ťu".4%CfԨL>0;BIgb7躊Ϙ!BN~~>z+v5_6.z`hM &yzvD\X̙3De>/~=P^YBԤ.>خ|ݟ{n]Gk6iP$]~oK wH&\ Tx 'wcz\8JÜ)8(X!Hhޠg8){Y n{na osEeI6osl,K^ Ɂc)(>ŹQm7+|̴Hg.weۚ;.:c$xíiYsF 0&d|ʨ%` Á_ !!盥 3M)g?BC˗|P0+ƂkA$iѬ_.7vJJgg9vg9d&:vc5ҿ~NO߼ D2@Áynԛs38R:1szYDmFDoUSB\"W*((qf,Sj:g?">g+I)#egmiº+W9J0=$u\(ބO|ɀ f%9AZ :wT_h6MWMd:~f/N:ՍUF3~Ļ!T$6 냏Sq3.3=2{r/ Fg.2!jn]?/n{$ci*j m4MC5L A‬qTK ͬ 7 >Bg7A A9vXR;"e%tldiܑy{q^]1 s\hIdLv4珆U}^@%_WM0LC^$.\n#uW`ݿç76Xlر!(--m\5 o+'.o>q>瓗o!'#w^4q{tBG PђHޱһ߄0s,w7CL嶓`M A |\{u;^,{>H(-/~3'p:'c;WaXrYpEt\j裏z7ҖW0|b?Mr GLdY9/r+~Jb|{K.PTzv6P3fVBCr驎.tyѰ* KBx㠰w]ޞ*z's()/ Z6l{x i$p9\ds`8fFMUP.4/^j|:I OՍ/>V]3х^gwӆo$$,nϱX-6q6S­NZgJENhxkruE= Avp{Mv-VKe89Q߇Na N6U6x]c:YV4F@8>tQ׹w|ٳܟm]Iye ,o}cTՓn㮅OvW9GbAjժ]IA͹U5[B* W@ < iQdx4w9],]4Hamɪd4|L!gr'Qd%1}z\ <]LZ;ݱea1[UҥKy3DŽB躱@V]8ugd3y|t]'Iغk oG=3ԝ72$+PG]>T_CYY)e)( 0 Z֮]ڵE#NvȒB%!L: ;#X=oU5-Nv %e# kco⓯ڽȖ:z#W4HCQ:.T/W5ĝx"$0AdB_kJ:FNbU)t,`%zM3lS1df+BScێS̀G ` =Q4bSUH(cxH$f[Rx &LjrNY·[V2zU躆5LdLZA$. g],>vE;d6!bx4ddR<%^ca$ORtNM7ƂBbx÷ڹm+0QgWf;gúް~lK a-dB:&1A}@a cnȒdǾՇ,+On)(-obWBOkȒLiδ?I:BV+<fy#$Jgy[I:Y6 *tqL0i|:t2.y1VMU&1f[B| MWX^LqY>9h L IӢ2Ԥ.H㤴%.,h"p 1ebǣpTTSRqrs43Ӈ`,XL<-#R#jkBMlEl[xӰZlQUA^A㱦[ E2!+J14] *ej["0̮x!'!I M".U,$z0/1DȔQ q{SHjI U{GM'#?7Ud1Փs$ܛ:)!S$D7G[q*QUWu3'HNԔ.x|?k} }S(&6x#V yjIENDB`move=1000;blend=1000;3R7T   ? See A֠j RUTZZCjZZj!֗ZR!R*UCT]j֚֨P*T UUSZ~RP_"DID"$H"D"D$D WWfW#'<#~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???ee$??@WF !@?Ӧ?Ӧ?Ӧ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3PNG  IHDRcbIDATxyt\՝?o}͖7aev $NNBhBx$NzOOrN& 鐰$&1ٌ 2A-Zګޝ?R%ɒUSOUO^ pp< p8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q#8q: p(.D5%prN[V.4(.kG<ӘP#9QxŖx4!H,+Ȳ?K ;SUg|;vpq>>E}M '<д<pܪRܨdj+-omh[LNf͚Egg'mmmlٲzVƴ:ݣʨ 5(*^w/CUܨ. 4McW*ng|S&W^y%r x#Gw^/֧qeyt͘ G6mT,Gm+[Y: O|pd2Ol~ B;{:4+ ̵]S8,{ȏ#o*0 )S8+ 'vTO8}"]wU:ƠYCgaZR`_^-~uh&cLw_W1ƾ.sTÌ?2gN.|h̆DYv-VbÆ].Gsљfe\Kā)?Z^gW$sv@lہ )dnwL_*3Z<hς%s/m=̻.Z[k939pl۶m j@HvOfoa]Ÿ|YU{+̮K r$X<6|0]]s2.W_$x˗~~ټł)v xwHS݌qy衯R3l;os]?\(U%F fy~lΉ4MšC?G{=[Sn~zu$?|*s'3^<vueh7Sxg o?ɗ >y'rϺudB'?j>:V5QӲyT֌mg{;KL>FakExXrQܽ..O,#-@a3_W@m*Uvf3$N %x6TUf?8ӗ1s眅:::7 _x=:ضm?cc5jfk@|­)ܟ@G;6=3^<<{dVy4px_|--^L}4J&Cl`x/ Bk.{c1unJ=jks=/[Xg'@ = <8EXj.4`& ?^;Y >j8yMcc hMxf"ܸ e ! °=(Y?3J< ZUqyjYrHh̖"5XȞ%;AO;kn\bYX:.d~e: &S!'ԄI$c47,z]!ӯG2; 3#3lTՍfS5 MˑrYZڍ4o ~?ck z?ڳY}B)Hzswdr~-Ysg9;?VD*ZU Ns">+Z&&MͥuoOO)]b^BYmmǐWqUm^S_}M Wgn'vvZ,G]O_2agioo'p%Jpݣ3F"ٕ0饻eL[7ԹsVRC2 C=c޿i&>NuV{yCVڶԄ_rV3=ejnXh\IÁRNK6-AUHD* M=6swTW_s7Ԇgg8vÒʴC80T$QyiXhLYx"$|^L8w{/_׹ٴi˗/g͚5, % n blaW_aTX± N;Sn"GU\dsi>:z!ٺu+φ X~=O7PoP=BBYP_Cg֥w[f[p=n.$yr~z> 4 L4 'hy=哊쎽zi5O*`ɒ%z%f{K.ѭ! !ax\OF)D8VVZb %Ĝ$z?E& HKԌ3gs0y.$d ~n2 Km,UvZer)R$LJ϶mX8~$3BS@A&WK-?ȭ  &z+uIgc+lt&I:*Xc oa4+t%T:F*"s$l)i+ ҙ8FA(_ܶ Vs>&aceZ! US @0ZMKlma-߁q1.~u57}`P@`>VdUqD 9 ت(slxRMO?m_|~5hoSyoUz7c:}"o=rfqӶ2t6A.\WpfBOf|ʊs'꺬(˂ T:A6!KsN0mc!ڰ+BQM{KbLYVx;΍dFc2$|YTKx j7&8}ZoG@fd4~Nin\H>1cs}F ]5k]9 @gWM䑌T[@%b.Ri_h m{ǢM{s+ ?H׺~7Bӿfoo[?UreZ!g4V{۞xFOEf`kB,DIebs)]anʹ߹e뺳 G3jM Ę]W}m+g^L]M1dgϞ=V8_^x ^[ͦU `u Lcc7+$d[^ys I2O9%cFqW!}d֧aEHSX^yBh$RfZQq]7Ȳ\Q#4Pn7It rͥ;* t&K U9>O:/zXTKKO2Y~v$ K 7)L;Pde%ߘꦕD:GZibdIC*i!3Z*1UHG~c$Q<.>}Ku\a񏀁!4YIѰdƊG'YEe$dF&+ŎK1qf|u4k.@'X)9 #ˋRZju@hbTjcWEylN6-5b20W_r+l=dI<.BpȲ rEJ- !BCB-$!I2,#ˊ>3GEih]jc6Zhew/Y4#imZJ&r\.Co1S^>C6!kܗhHg'S$HpP&.=CU\nfd3cZ%{z}z+I\ΚO襣(.˖&}5<} qEH]񟅪2ƿ~ ɔ 1OTfgL1nP$@S\":LN( fh"ϲu11GJ`M$%\>e{BpGTi "x<~(/o?ᪧ Vɜ%Nx)Xmسz1Ni)`=,;xv/}c'hmZB}M nT:mWuߡm4-!荐ײnhfWguoK:鑕nb*ѵ!42$)_7Bړ R|[Y@d)./A_ۃD"h֮zKb`=_ >O_tZQU7nիLft oKU|YWR#D2Fo"eshi\dVx6A $[ɤi nˇczH2 [3E떍n|$DMEy+ #J4ǞW jB0>@KbT7>;]X͍Pe\ , T*Pb%7i{~j.+%AW-لz{O!D ԓa>OY9}5eU0>MuPdZUU5Re]H.UUQdǫJpݸ.T E2 '69걖EBh'=tCmi\BmP)"hKѭq]PUQq(0Nx<ȲDl0`d:P㽇,IHx] ca!>OY9|X|_Jq֙BU}enEBNn 8LQl}<.1f_gAΘ:*2Uɤ{$R1$Iw(׷g\MˑJ$DϹˇKHTžqsL6M25D^ʪ̡357.Ճ[V x2lSU<|dfdz  *keNu Z$ͥIg\)sL6E<%K/>WVaXf0QH[ JmhGcLȇcHШ4U1@*=`dIoVm%1)J 9r=ǺIek/yq中Ý{ "Kk/ Ms(ݥR G\s<ȒY /bߡPYlGSQ]FJ'9>XO,P'@>(*.3'ɡPI8BFIENDB`move=1000;blend=1000;3R7T   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPOee A֠j RUTZZCjZZj!֗Z֪kMiT(Cj Z]j*U֠) '"$D$H"D"$H$H"DH WW Wf#CUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???dd$??@33U@^Dv!@?]q?]q?]q??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4XPNG  IHDRcIDATx{tTU?ᕀAe@inб}vs^Ý˾=龶}gڙݎb봢 (ڍ" y*UzǾSUIZ'8Է~{}~%@`ah`XHK<ic"m,X%c6x,EXHK<ic"m,X%c6x,EXHK<ic"m,X%c6x,EXHK<ic"m,X%*ZdQOF~Kd !D~DJ*x[}{5MM?U;,dˁ "< 44teēaup=MMz]O9{=瞬U]ğ6:;Ѳm5œM@V߻'Ntd֬N~%()c ZEw!@icH>,_bD>2<GwqpCAmlRq!tJ&i _3`YR_u1&ēM֭[Nj/:fMӋ MSVהLKׅNIk?WުUÖlBV'qzanVyev5̽`1vUKPD!:ij1yd*/~|7C8Btd+R]zʼպ!jy,2c =:sn ִq8ʼnŻI(Q5)t(+$IH_,_>I>| N8NNh/[2t]o ja"$qȑa ︃3!t ]SPx7D7q%JGW/| JQU-[RWA{{7ޭh"5>ēc/YB{G̩Z)bȀMcq-N^0Ȅ$S&\DmajU .dܹsX麎fĉj MWihOA*V9Kt1 /v_gcm+fv馐 3i*Ov'a|ax:o;z>[{C.OyxFU:u2֭[3o׈D;(LGBb|ɴ!c'h}݇E5ktinnY1I$zqkxeX0P!ӦM#p} xmƉ'رcLj JH^ާ+M< aXx1LA)@uڻN{97䓷lu \u? ;v^;wRYY7LEEBZye H,40$ӧx]e 9ϡCht>1|¥|CFܾcǎq1.2-_>g&p#L$ Ăx\FhI]脻;sLxv7˶ Jk߾}q[HYnNGB఻H I{G;sϳs#xN<\w/gŊ̜9 Sr?̆)~5*++9^Lpۜ? ]|Y**&"IQ<%N'$g,[/gRY9n/LcgHLj#֜6fkժٶs~7˔)x9{ǂA|l2{fc.g_^ppgg ݹ)_D" O?7tْDP.41K/}isOT@ Cgܽ貵iIamHw.`s&Wb躆msa'#t[4`G Zeִ)/b\$B"0}Y%gx0p./^Oۇ,9v4MGS^O9”8\OJX>wn@:3("K<(S/uqx\~N/'Ϻϯ~+\.`뺎($ 8x.<7nekGq3q|x\~|" %=EY (yJqq1zYhQS'\<. P$(>wk5/nyƍ|ࡤcǎMG8ZSvh<̚I̼ς x}]1ĞˏܓJ,[+UUU=S}>68Jp]H$I$goBCU4]aNiFV 3%1;Uyԅ@7 IJ=cS0B1nW?C'o:̏?83L{ꩧhnn#w煿4ry睔_^Z◿ {btzf KHāDK9L0-O 8FN5eb Hū;>,\)//| .gaߺu+œ|ٟģ=z :$dDd$Y&ېe6َ$)/Fc!k^w?P5t3suoB4fP+(PF[՝Oy^֮]ˊ+RǴڟcN?\`ĉ\.,sRI&}4 ?#^H6#dنf7K6$IPuΞ6KHStM>}ɨáJ(%+3xzS]Mqq1۷<38ps /{ }Wfݺu|Gu.}nƴly M/!Ʀdن,ȲlD0@%ؤxkhf LPˏ:[vi+榛n˗zjط ҰLhx%JWgMkÖܼtnjM6qwgĮ&'4]WJM26N,;_1>Obvscun_ϼyR\SÚiF&dHD%O [Sxضm˖-;k6 ?dKk6M?ϖSG)/+(JEH6۝fv}9sN2P ѴxPLsk׮>;<9B4>D9D}qs5Ɖ%"^<.f71+nB4]Mpw K.1cƤ[+Wp;8nvv;lc֭[EQLl߾]GjfΜ=C,?rJ>l1ָ[5iWn)yD}suF]l UV۷[}K==cK,k֬k׮5qcL3^6?ݻws9nʕ&e˖1i$6 ([vw͖1ps'ٵkUUUAfϞG8VpضmI51Rݛʹ|V !Q81μyX`f"w^QeΡn.W^vģ>*.]go]q;c?3fÚClyyϓD<Gw{{ǰ(7 MW9@ވ ?W U==c۝|txkl>r&NaBT+ =p\$oPDe/N+O:N;,y(y#f$Wx_kQ l*c4ހa節bil!v'7ozS ?v5%ii 6ό>'cu yy> MHeR?ɦj"4$nfeqv2y!d90䬠Y@]í4Yp˒?+!H9 M@s $ll˚I'>P$'#9/P# N&'>#jH,еx\a,r/,t7\j>3BKIsr[bxI2&+ÌvtZh1I NdɆtS8^(%p(c9jt\IQGxCCv"nE]xz-21dI"Ʋd6&i$ms Ɋx= {2xct8í^TMAŜ鋨x)GOd{U!=OOww8WZNIF=\nøs:\ve2CΦ]y7GFZ:[Qko6 qq8\ ˺}C-tՀYsC`|"mMn{!R;N]:s ^w78Wm8L$I[CtCC/SoC(Ȓ.4Bf_V=Ӎ2t;HJ0 H躎%P5##]S*9,Dή*dF5/́]!2% *F'#ߎsh6F3q0r ?fL1|Nn{]אd up:<*LUM!nˊ=kn$QzMStcu U5<)hn_F09MiwaLZ99!r[<`zu]&Y\No?4i<!P8ڝQn^x/6XHwUW4L#n>ZI;0gR# ē>0z $vBO2Nj Pkw 1tǺYJ@^MU vz+3/pbz304C%2H<`HGKu.%I)0ǃtaʛ1R'If8U[UKRߞI"tAQA)9i~'I297w `\kAJ]_aG_$a=ӳNaI"G)Be0ţj y%*5sxc.vٞ%@d<.?K13g(-Gj~z0X0g5Ч1mvlN4\fz$ 3iJOz<~o6!yE44zO4n $PDߒZE0`\q)jU&o)OǗ;s >O!`.]3@QN$$F v> gcR<p;l]-[Q(jMS8vЈC,_!Ȉ.b%݉z2θn@;i<Ł#;hj$1:C͸^4MnwP(dҸY;؟):CKIQN>jmȲ!IENDB`move=1000;blend=1000;3R7T   ?ꪪSee A֠j RUTZZCjZZj!֗ZR ZjV֗B?֠5֪kU֠jOBJO/I"$"D$H"D"D"@ W{Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???nn$?? ZS@$ `f4@? fH,F`='#i;xS8yRHC*YP׶PkF(;pB(A}U)zyK65 \y/XBvŭ2L t)l;Pt?*$Կ) O},z 2B ڌ3^猹ːҧk"gOag?\ugƿKGj;zNHCr:Cjgdq *7XrrzScuDxz\i'T>|'촽3D@~YAQ0,aK'DM=qtŶ"~&eۚ!xaﻯ2mgJ`+0L)n}(%񥇔>Rae5 &iբ_9,?{ib0S19c!Ɩk/ by 啍۶01H˗^gVHaF24ͤwvd0 !)+] juHoxbrAeVwlN2XAlܗ=o`}G:}*u#=@(4"s\EԊ! m@WΏ|qB Ti_{'Zw뢹R,ڧ`M4'b0 :)c"C)K?YAe$365fWD0TfL'M+f S8jƛʈ(w2=Pyjb46P+=t`" \*"qhU^%!i,'} "YgQ B+FJUfCAҮb ٓśM|n8Re‹k[J 'kI%Nrqcgxi80ԭc|Aj9XV9 5H$o "O]S  rIkvJɅeN0eFƞSSw4+AEBL²b /g,,,-B4h|hOD;TFVM=uM%OiIЙaaV,FOmͧ]>S9D;ӓZP0k Ca?BdyO -7~PZI^TTh|%lӐ<:!YZA*Sh)5dMm o<5{ˈPL6d6I Vd[Rb«,vS"5#˧wMF%UUuڑG' Ʈ2ZN e.[qtd?Lv,RU)7JI)yAlƊDzHL-3iF|7 T 9rb/Y`Q(6qe$Le0aN`0~H[zFHn"e|aajhJZ {$SC?`nvblnq_[W41\<{_VUiID ;#^O~'E}ǵB`ia SWBJ˦k|X6j܂ݦ&Vˈh|!x$մzN0rz 7܀E”#m``R`퉊~ԄB%yF[d֭] 짮!StRw(e"gd{<\n俔D91X㦂T >޻[[KF,&]q(\8fDrb֮6($RR Hvon{d22){(/>H|nrיwY,tLyVB!y/}*}\s52X}wPhUѥO:=@*=H2=Ͼ9#ƈgs ʃu+?E7k%;^l[Řl=y/]~뮻س'ϑ#GXt)Q+F=w$ICAl'UrMSL̞h8ހRP _?yw4fٙY>ty.,"$7s s!77e˖Qϭ[tW&= QsF#2=鴭 :;Gɂl\LfZH鳽M^FGj t`^aXx/O'ş|w÷~;y~]karhe;笢c 07ȬM_/}7⭃/{V~).ujk9-S#_D=ٸq#_kyW߳f e 7/hmZv45OLDBk8yNJDlN@2u;ｎ3?Ϟg"\Lw]xhm绣:ߍw͊+m \!MLY WJ ͽzG͐) СC|#3ࡇ*GN`R'9^xS6my‘ 1꧶aܟ۫{6sYu[ab7G7˙|YvMAT-95?3Oxٿ?ׯ/}!e ??~?hmm!N.ҿQ1Xym 4t?%Y le[r$bX8\=7<6n??N[n{Fc??YynX#3(p ni̭1ٵEL ӲL ˌ2 t}98VE9aΞ%#~|3{m'xX,V~d4ps.͸/m~!_9s'>Q 4 @ ĔŻBgH=Jk}?{YBh8T>Y90[ge€b/N{evVreuȺYrӦ 96nܘYŦMSt`brk[kb r؛ضn;HIN {xuw#bE1r,߲e 3g䐵 Q`*cԡT_fӦMg DD"<3s=w/_|_2W\K%@!岥dƠ("ȠhinCJ0- "2#V CH}c?|sWg?͛9zsqWܥ`tW[8l}A.]Pqs=[k iDsNBٓξX~:Z {rtb 4-.8犢B,_z?C}w~_ncum6֬]/7?BflBpG::Za̙3W:t1_h9gg-_a={AB*!OGAb aPcҵj r쥘BVK`}si;３d2Ol9/8V6=˂Ǿz~)w)}2<[d.X >8\Q QVHUEKVI=o0Bfr:>b8s[,N?]UVH}٘;ٹs';wd׮]H%9s(|._&kWyf[m6?Γ?9ǎ w.^TND8k(Gef&$T>J2+eWfmd8!F}G1 3 ^#o(3oY:l@)|/jZ òekv~ahhsҗ׾=tuuOO?ײQ( K0ꥶQš.vƩt֬uq4ҐJb}HcӐxґp$:{3S$X~Z^3`2QJv8nKp=ب|%黼XVI{{;;}K_;?qz𓟌.0j-F&۾r}ȿ*篿(M+2c(|LeD*ÐЭt">D[i] i->}95:$iTHҥK`…8p`e: $8z+˖-c۶m8p?V|9# M*3 Ք(XeitˌP| (tF@KF𥏩$JD aHq@uq1h H l_! &wJVxH$Ϫcǎ)s's̈ZqeѲ>T?S5օ;zW<8cwՊ^{?Sx SB0ӹxҥ9&w6!؃$5`pЦ:f>_@tlxrUhL oFC_B)U]T<y8pJyQ%O%J*JFmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???jj$??G!N@!+6@?`Mw?`Mw?`Mw??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6!PNG  IHDRc IDATxyt\՝?Z.۲}c&B:'!aLB'ݓᐄtB$O};4 = ƶɖͲZ{զŖJU,Uz޷|~PLsqCK;9M{V"V.8J)HPA*#-vll'F܊aQ5_ӿyABR(/_"=s˩EWĖ{#a?C G4ށ.~H&-"H X8vlZrعq2:c:}C%x=>ۙN`JfJ+8ɉCΒ+.lGZvöXvŲu(OpߘyL]W@܊0934, 'TRm[_%aLF&@ ^)`|;ٝw ݌tMYFwZ#YHhlX@,>㠔C/`܋Tty;<  SPk/Kr0@ c{7eǗ ^Q GYqc-5 X| -mw<7%7i2Y$B $0IAt1a ң %}!hY_&~JJg ]GںD螔Jxr?L1G9XkWfH)hmߋ@Xeױ+ 10<f \.1튲:*Jk#)Ol͊I8g&z7oz!d`}A^wD!OϹı80|&B%t:u10 Q ێg̷N%8M@7)yN/`1R^~m=u{toɚpъG7 7aOAJD\gAbħl*TB܎"sQ25U`l5]3l7-;g%͑](⹫Y>dEm35x{JIŕLJ|9F.PiUF S?BY %7u\5 Y2w ҢI?zbĭ1;ڕuV(/A)=ҦQϪ]HM"x&ssDʵS% Tii-w ٸMfJW{JGO+(E,aQӅ:{#iJ_})?iL_<7#xc܆s~gzs4!uc*M4)lB o}#RuߕD!z|PWvo.ʾ#;>Zl=J:zZ4+tt a'eŰ8Fgܶߙ:ZBp[w9xO>~Vi'\EVH.{q"sNjW@US*@h)43I"C9KI@E"Wn|6 x@edu5ԬrywK9?;MrRaK=*n*Xٜ-~oDZSug,;#m| arCCL=^k>GEi;aQ (1̶ȳ]GC۳;_-]I$ = cLrؕx=d&QUg,u$=.ʹ$ili+NO|%%ad0 ~CN<$A9H* qF~ƭ T굽 ܱu.Y` 0C\;&Ѓ9(XW { |h7J?9RHΤ{ֲW잳B<5s&>6 H)AHaĝ,%0xb D%ug% pϚgDn19/L{8㞑qъu5н 9/>$=k2"})G2]9=֌h&H%sNoTWƶ MbyDKRHW8Hַ9rb$.OYqxzvZ00x(8TJjp;Ubwq =zt|,lb|Ezh^"@HK*KRCT+ ձ|3vZӏ7⩯jƍ89}It5cQ(eVbk2]YI[i$t}uzrQϝåhn\9eOꪚSsE1㎯']D':U>G}HשQ:BG!dZd5793}AJCx}>vx-;ҚV@a.Ûm%fH6;Ω44=wP^Z)L0`^ycK.Zq5~_Ӌa^ !CUFrhe[Xv|zo+S[r8@Ҟ*7ԔZ0L[?眿Rw5Abzy}A>V|^)%nq*Ʊ%6;[_< 6Γ1K]3S0«[uuIWۓpF`*DD`s#] K Ws h4/~3XGHq+AIQyĽhߨ. W"0x~ϓp _ooSYVNs'#LS2 a`FXnVb _1EJ+ WAS=<:>z);[s@^(yy[GډmoO?4GᎻ; 2NsmEZO4 g=zO.e(o?0>:\TL-{Z8g_ f#p&|v߶mpx}JfC{*xr /a)Óc'xX1r0[r]w9r5umR~:8%s0#5O_pzÇ槏6y7o?H%ٿѓ_</Ia!t^yo|<mo1o$23ZlذF,¶mpwCywYd '!('Np?_)**rU톢SQc /}s,'gY.u֗e>LKK {M~?|7f( ,hvSw[ei0>dDHBqe/ʒҵiG =rc1.կ*L vmc,뮻{k8UxrS~UP$AAdֵW2Psp7swz=7tSNiNqq1o&?Ors=W_o~~"{Ӥhʘ5\s9ӱ4=/6;Lx'wz)mE4;wCpŒ)׼;t emךw >G9u8qW I8Ӝɭ.c[Fy9+_/;yضm%%% <7WVf. m|sarѷV\_ɓ'UeӟfNֻ;y-iQ:֭cÆ }>`ʭSZj8׿>;/吏zJ}Sz֭SwZ5pVa-]4eڵkw/N95m{[9B58P 9>2۷og\{]&0MY{.r|+þknnV;P+.KWV[?<5efཱྀ#/|/x yFʒĈWN[la˖-\r%\|k_[މZӇr뭷rlxPc֭ysժUÝ'} x1ip:͖-ͽȊ99ˣN;)mY0 pC̰<`ǃa<呰Dss3--,/IL9JIo-qG(jȪ&;8\|qWUWwqu>9<=*/!nEL$nJS H`+‘v}^w\JsF'EE`l'ٕG|׋%%:/u*N7Ez4MJRa^zEEr%tSo~sя{N[H4Tq',w4V(ubI_p7=00P(lT_x/oI+đ:$m9JgQ調.:;Qc45FY`Y8̒_6sB{??䩩HTrDה]r-O7ٸ|p3G6$1й$&yyvp r6m F֮mq}@{$pױ옻ܴ n <}ȹqN]2d `;ְq+JIQ9>o0i;>o Ym Ϭgto"֭{9t'vjcӦtwKΠPCn~W5S_5/؜[Mh0ơN$p-_mm[in^+YOpXZ^!m䑒ƚҧ(mh %PBn79,Ѱm ^&OGO36ϙqJGa{yҪ:Bxf >bY%Y1اm$(gu ^tXE 4v1BH%V+gqx \IDAT?>lb鼋Ǽ%%e5G0H8è I_Ӎ>7:!mӞ8 ♁) %}MÃX8Jj`K ˊ1u$y4 ♡J0 S/x )aV*8b`Σ NYq!>o 90 l"nEL s3:x dM^ k )5Țx dMA< YSO)@S k )5Țx dMA< YSO)@S k )5Țx dMA< YSO)@S k )5Țx dMA< YSO=|qevIENDB`move=1000;blend=1000;3R7T   ?Qee A֠j RUTZZCj*R!RZTRZi/AZjV֗B?֠5֪kU֠jOj DH"H"$D"DH"$H"D? WW#O9UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???mG?m$??t/RQ@?@!?@!?@!??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7$PNG  IHDRc IDATxwx_3MͲ^&7!clK |`ig SBBʑ…rI yriO#GBHa5e˲-˖%[fwU]iU}?xݙoy~W (Y%@U#膎a輿},rQvϟ6q;7[TX[pb; a`a2ٍZTXҒf)F|97=m-\C`~(6q C|9짩ug xܸ+m΋e;CP^%8f?IM0P0C0 86:y&R3BMW}AUzLtg/I(,yZxp`},|\-,R[*K +!_ v׸jᝀ)n(ylbwWmĎX=<VB֦S} "wu"嵕ե?@+ovF`uHD$/' VdtCC%ꛫ)x9.AEE9tKCs5p cOi5979y1t-D2ov(܌ ow .(:75NG8SsQ3G~8g:ߗyλ٤uguM9t CE^euKKLF4k2|8AQͷN0r>IגDQa @ moTU8c ҒPO[d <AmDT4qVDQd;jU_zGq@rv\y=^slJ!ɳd-:UI GRU[NqO Mר=/¾[k|y]1M-ȑy9VfEy{f|5n4tC$I%񸳨9Bsδ9zbC{kN*7¹W. 䏢#;QՈ}I9y1'uވ*3r{hFKhcQD*kpsUh2 MW5*8'~= EwUzQOg'9p9jalNt@:+'363fBr Y\{(39Yu/6DSs,su_zr~"$y1qev\E16=Gs)`.\2Ba?p !lo]!c1 {/Q9WSpf]^_ϓM0Ԃ1,-(w $?bDx}>lAT8TqTy:19e< n4c,{CʎڞgMSC!y(RKM}l@VBLai_qoLQN[DQTE],wFSй|iò鞡ju\*ST34#(7l-Iw|]g r{[ugΕq\Yʬk2Υ3v&7VqyZώCo64Sq'rj9tr3ILUՖh{ l;EdtIԉAJ< -|vr1WI \͛qUtDݕbmI{;<a5'(`u w|+ c@L揻ѝA,~B]i7*}f-.C;Ɉ ~@ZK9S!/ݥgv {2t5ܡ@)yLZobҘوhL [a\qOל0tB镙(ۂB8mCrzD\Zֈ 8;(qAd/^r1S GB,U^ :s{x>TpĨ ,#E.# Ý-=uwXO ,Q(ٝl-^5BEA<,Ydӏ` J[K:qjz@UW&( ewvքQ'/}GIvoqɴv4C|p\!@tچVTE6JS(CyT-)KIrpM'վ \ZEU MҎ=[c$2EwMov)D;.rN1}9S? ,YBT(8$N:ε&i֕um ɕk{kHUSlZ?q6O.GΞҿb `֫,AXiEvu]DU ]''7f-Ni<}D9vToy <3ZiĹShbry|ds 9 ABIz<{8RvcH_28c$1ɲ|n-1MՄ +u`{-*:N>r-s/uz]mCH(rew!''^nũ ]}VrY/Q%9Bu:KtBiuE Xщb/[Ì QuJú<%j%@KLX QB/q M8UݻZַعs'۶mO;v;bCDH# m Q,ם jK"zo$tfNcs->75V^ͤIxg?rGK._;Qw,̺l݅h1 l_DKOr$@7Ǿ= r3|8)It_WPU￟ɓ'3vXV\ɮ] پAY&&YEKlU3i许F|4M%j`քh#y%l2VHiRT5LDٺ.kh`PP$Ʌ?Ԅ<^Sq!_{*r G]D7."' QuM)MRjOZa蔞oSNeС|Ik~rMѣG)*,`ШLaڕ,n*k+Q%LméB!Ϣ97% y?ɳLѥj+ːBML]Lbf}yI$х$pIn\LJϛŰHZpbą#N`ˮWڜswqF֬Ykiy7|3{gHHW;n"jOb&F8]sMSkęI77}%"ENXčb٥PS_$EW܉4]`D,=7+uaЋ%POc9-B4hh:GCS-ls/鰜i9@O{^tDuuu5Uo8vH6o4k9[w"%@9ELCR6q(ZP8Kr.$݅Kw:`:&8RVA)4_>9Yx39Po=(g(r$rqҨ2~8(qbgutE1UF35,vygN^ğiu"(薂I5Ad]Zn y9E]r2tTMGWgQC'j n~= $R4N] ;eeeuy)*,a#t]$NVeK&$ꉌ6y KP4Q g^זvIq0t4KJz|ym.z&I$SbYCdHd0 袎.<ֹ.jd!Synߗ(" "|e&tݟ.b19\8{5:F5)DMe'ĹS淭H,>Ϥ6[ CGUTkWxG,\ZUCo]6!6o)I Yp?qʩ&+V3faݷ^wbM7՚Ǽ&՟(}sY5a&[:eV99o((Do& &qt#GRm9ACvqz̜9X͛)));6cQyl)y9 29S9rïH#Rq]=ǥw|7Ò>oUJ`ą.Ʃ7*yYom\βO2'L_ϛc*C0;Y79s >leTUU1uT׿vx^TcCh#ˣּ\[Ģ9bVdѩ|Qa (E&y~|'Ah 4UEq|-:ԣ0vĔngWsvyyyrp,tQO|ӻ~V_`BDH Y9j?;;7Oƍ8~鵯@ʁ; 7,o.FN9:#ҎCo%\n71(wF7t‘ ;o|=ĉ] ~LrTI0idk =N%h%.y10y{Ə. nz_c`zrwW sQa aPTťū(4w3e&f͚Eaa!,S,ǎvS^^V;ܡNPnlB#UhjZl+۱/'y tj7m/p˃((j0Psͤ aE<5u'ㆼH$qTaovux퀓?) U9'?w'{̀$ `0o\ 3| O%j"(vڽ!һ&@0-h԰IV2KsSQuPO H Ԅ|G\7 5̩@( vŒP5 'AfFSNs=ǦMذaFJ[=Q*ZfWɞL3F28o8y94%/M~ Bz J,e3cؐqCBC fDAappMCiʲ*"7ndȑi)5 GN#;+]ih 0s .I"7'bik.aKq/F Nw)Ki'j"t]GQdꚪBnvz > /yR~k6; s_#'F-zfr37: js>hSVN?܂kv֎(*K0f!(:ꩧ"2Tѿ?<6l{:d>' 0 O=Ÿ$Fts/u'EV:KNpt{/5G~:HA(tMC%i6lz:f9rNi&vǂ~_JJ`ڵ 7IrJ,O=1}H*ynv'Oĉ1<Otzme+´,HKJz coyL)ca߾Fͻ+̚'C7$gx>\k›,[q~eVChVILkE(?͛9rҮ5<τ1PoEs<AZD0y\aޔJ<>0  ue \t6`.O>$?lҬ{?gsO=e愞mE>u&7V#!ܖM(YqHQ ~Ba?#,w#rAo='uAӵ" Ge?A9Bz !H\acu#>C܈`D"!‘zե%c;1YR:<禛nWx:a>FL%/'GwUS̛QBȑ ?0z',ɱNG5kmOT"@829]sgJz`jgNNN|)drU"Frsgk4#Gdys팬 `nƯ+j3k"ͷ`G{w}v"\b;(*,lV0tF=5F *݋3[9w=PR{ ~>pKo,z n:***T׷k)O?K5]9ɲ5^Kt+&\(sn2 edȓAȐ'!O)#C RF< y2Hd22 edȓAȐ'!O)#C RF< y2Hd22 edȓAȐ'!O)#C RF< y2Hd22 edȓAȐ'!O)#C RF< y2Hd22 edȓAȐ'r_iکIENDB`move=1000;blend=1000;3R7T   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPSee A֠j T**CT(CZԟ*TUV֠_PuZkKZBP_ԚUWU5P_'"$D$H"D"$H$H"DH Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg13R7TB1S048 @48 mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg1~binding site for residue cit a 421ac1!% 1vbinding site for residue pge a 422ac2D1~binding site for residue pge a 423ac3bR\ 1vbinding site for residue peg a 424ac41vbinding site for residue gol a 425ac5_1vbinding site for residue peg a 426ac61ubinding site for residue cl a 427ac7XX1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES>>1met->mse selenomethionine MOD_RESTT1met->mse selenomethionine MOD_RESgg11ADE '',?}?ǽ??}=?}~ߟ??~{???}={??}????{?=?????>?}{?~}ǿ??{=??{}}~??{~{>??ߤI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@pBp fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT!BI$"""""$!BI$!B$!BH $!I$H !I$DDDDDDD @DDDDDI$ DDDDDDDDDDDDHB"""""IBI$I$I$IB!!I$I$DDDDI$BDDDDDD!H B!BHBI$I$!B!$I$DDDDDDDI$! $HBI'?333333?333333?333333???????@???0K;Kn@33radenylosuccinate synthetase; chain: a; synonym: ampsase, adss, imp-aspartate ligase; ec: 6.3.4.4; engineered: yes3R7T3r7t P 64 2 2 BvBvB??@ a???@_+??@_+? AHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW aa          ppf ffffffmmfff fffffUfp ff ffffff ffff ffffffff fff f!!!!pfffffBfffffBff Uff fffffffffffffffBfff ff ffffffffffffffffffffff f Bff fff ff fffff{f , ffUffffffff , fffppUf f)y:?@aacit  1DXcit citric acidaapge iangles Xpgetriethylene glycolaapge2 Xpgetriethylene glycolaapegd |b @Xpegdi(hydroxyethyl)etheraagol H Xgol glycerolaapeg2  pXpegdi(hydroxyethyl)etheraacl'ee  ܝXcl chloride ionawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233 _mse  _ser     _lys   Eala  Easp $! "#!!% Eile%$&(,%'&%)*(+()- Eile&-,.04-/.-1203015 Eval.5468;57659:88<  Egly6<;=?<>=@  _ile=@?ACG@BA@DECFCDH  _gln AHGIKPHJIHLKMLNOMMQ  _trp IQPRT^QSRQUTVWUXUYZVYWX[W\Y]Z][\_  _glyR_^`b_a`c _asp`cbdfjcedcgfhiggk _glu dkjlnskmlkonpoqrppt _glyltsuwtvux Hlys uxwy{xzyx|{}|~}~ Hglyy Hlys  Hval Hval Hasp Hlys  Hleu Hcys  Gglu  Gasn _tyr  _asp Ephe  Eval  Ecys ! Earg " _ser  # Eala         $ Egly  % _gly& _his  "' _asn !"#' $(/!%/"&#$!)"*'+-(,.)*)*0( _ala #$0/13402105) _gly154685769* Ehis 698:<B9;:9=<>?=@=A>A?@C+ Ethr:CBDFICEDCGHFFJ, EileDJIKMQJLKJNOMPMNR- Etrp KRQSU_RTSRVUWXVYVZ[WZXY\X]Z^[^\]`. EvalS`_acf`ba`deccg/ _asnagfhjngihgkjlmkko0 _glyhonproqps1 Evalpsrtvysutswxvvz2 Earg tzy{}z|{z~}~3 Etyr {4 Eala 5 Eleu6 _his 7 _leu8 _mse9 _pro: Gser ; Ggly< Gval= Gleu> _his ? _pro@ _arg A _cys B EileC Easn  D Eile          E Eile F _glyG _asn!% "!#$""&H Egly&%')&('*I Eval'*)+-0*,+*./--1J Eval+10247132156448K Eval2879;>8:98<=;;?L _ser 9?>@BD?A@?CBEM Hpro@EJDFHKEGFEIHJDILN Hglu FLKMOTLNMLPOQPRSQQUO HvalMUTVX[UWVUYZXX\P HleuV\[]_c\^]\`_ab``dQ Hile]dcegkdfedhigjghlR Hala elkmoplnmlqS Hglu mqprtyqsrqutvuwxvvzT Hmserzy{}z|{z~}~U Gala {V Ggln W _phe X _glu Y _asnZ _leu[ _lys \ _gly] _arg ^ Eleu_ Etyr ` Eilea Eser b _aspc _arg d _ala e Ehis            f Eleug _asn h _leu !#' "! $#%&$$(i Hlys !(')+0(*)(,+-,.-/.1j Hhis )1024:1321546758596978;k Hhis 2;:<>D;=<;?>@A?B?C@CABEl Hser <EDFHJEGFEIHKm HleuFKJLNRKMLKONPQOOSn HileLSRTVZSUTSWXVYVW[o HaspT[Z\^b[]\[_^`a__cp Hile\cbdfjcedcghfifgkq Hala dkjlnokmlkpr Hlys lpoqsxprqptsutvuwvys Hglu qyxz|y{zy}|~}~~t Hlys zu Hleuv _lys  _gly _lys  _gly Hile Hgly Hpro Hser  Htyr  Hala  Hasp Hlys  Hile _asn _arg  _thr   _gly        _his    Barg " !# Gval#"$&)#%$#'(&&* Ggly$*)+-*,+. 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" _glu "!#%*"$#"&%'&()''+ _ile#+*,.2+-,+/0.1./3 _pro,382469354376827: _ser 4:9;=?:<;:>=@ Hala ;@?ACDE@BA@G Hglu$AFAGDHLEIMVFJVGKHIFNGOLPMQNRTOSUPQPQW Hglu HIWVXZ_WYXW[Z\[]^\\` HleuX`_acg`ba`dcefddh Hleuahgikohjihlkmnllp Hala ipoqstprqpu Haspqutvx|uwvuyxz{yy} Hleuv}|~}~} Hlys ~ Harg  Hphe  Hasn Hglu  Hile Hleu Gthr Gpro Gtyr  Eile Ethr _asp Hthr Hthr Harg           Hmse Hleu Htrp  ",! #"$%#&#'($'%&)%*'+(+)*- Hlys  -,.05-/.-102132436 Hala .6579:6876; Hleu7;:<>B;=<;?>@A??C Hasp<CBDFJCEDCGFHIGGK _glu DKJLNSTKMLKONPOQRPPV _asp LULVSW[TX\cUYcVZWXU]V^[_a\`b]^]^d _lys WXdcegldfedhgihjikjm _arg emlnpwmonmqprqsrtsuvttx Evalnxwy{~xzyx|}{{ Eleuy~ Eleu Eglu  _gly  _ala  _gln$ _gly  Gser  Gmse Gleu _asp _ile _asp _his  _gly _thr _tyr     _pro         _tyr   _val!$ "#!!% _thr%$&(+%'&%)*((, _ser &,+-/1,.-,0/2 _ser -213572432658 _ser 3879;=8:98<;> _thr9>=?AD>@?>BCAAE _ile?EDFHLEGFEIJHKHIM _ser FMLNPRMONMQPS _ala NSRTVWSUTSX Hgly TXWY[\XZY^ HthrY]Y^[_c\`di]ai^b_`]eg^fhcdcdj Hleu_`jikmqjlkjnmopnnr Hthrkrqsuxrtsrvwuuy Hglysyxz|y{z} Gleuz}|~}~} _gly~ _leu _asn Gpro Glys  Gglu  Bala  _gly _asn Eile Eile Egly Eile Eval Elys  _ala   _tyr   Eala   Ethr      Earg         _val  _gly! 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G J I K M W X J L K J N M O P N Q N R S O R P Q T P U R V S V T U Zs _asp K Y K Z W [ _ X \ ` g Y ] g Z ^ [ \ Y a Z b _ c e ` d f a b a b ht _lys  [ \ h g i k p h j i h l k m l n m o n qu _val i q p r t w q s r q u v t t xv _phe  r x w y { x z y x | { } ~ |  | } ~  w _gly y x _ile y _lys  z _asp { Gtyr  | Gasp } Gleu ~ _leu  _pro  Hglu   Hasn  Hala  Hlys   Hlys   Htyr              Hile         Hala            Harg                         Hleu    " &  !  # " $ % # # ' Hglu  ' & ( * / ' ) ( ' + * , + - . , , 0 Hglu  ( 0 / 1 3 8 0 2 1 0 4 3 5 4 6 7 5 5 9 Hleu 1 9 8 : < @ 9 ; : 9 = < > ? = = A Hala : A @ B D E A C B A F _gly B F E G I F H G J _val G J I K M P J L K J N O M M Q _lys  K Q P R T Y Q S R Q U T V U W V X W Z Bval R Z Y [ ] ` Z \ [ Z ^ _ ] ] a _lys  [ a ` b d i j a c b a e d f e g f h g l Etyr4 b k b l i m q j n r k o l p m n k s l t q u w r v x s y t z s { t | u } v ~ w } x ~ y {  z | } ~  Eile m n  Bser  _thr  _ser  _pro  _glu   _arg   _asp  _asp  Bthr  _ile  _ile  _leu   ?cit    ?pge          ?pge             ?peg              ?gol            ?peg        ! 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