<3.6-1h/data/swissprot/ 3N0L.pdbdupa 1DFO.pdb"[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Serine Hydroxymethyltransferase From Campylobacter Jejuni[/h3] [p]S.M.Anderson, Z.Wawrzak, O.Onopriyenko, J.Hasseman, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3N0L" target="blank"]3N0L[/a] [small](deposited on 14-MAY-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1DFO.pdb3N0L a_3N0LB1  1DFO3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 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y t `C?yyFF!Ǎ'@ AcSIs9Ti>Cܤqufdɤ 1Wc.#> /j$L&S?Ri IRx9nCt]DUezEt} 2Ib I ܴixV-D1իIwac|?q48%VEYVugj5*.p_63ץzvqiz͑f)WN$Eu$XA@L,c-^CU J)t(*FbO& eJ.[h1{Wz %|?LȦ҈"q8k[MAVhahcY:aGiݜ nfsifcuд.=,.qrvhc[lD1Z\~|織JŢO&y퇼([X}^C:(JZYVM$q].^$qpp?dI ݥad*-sB'ODQ}t]\*o!*#Y2߯P.WT Zrdcr]"no|\nj GIs QaY1jJ[h 04NNNpBAEx׾b舧iw[* DqLw2Af~S۪y F#p% \ҳ,ʾOIQI.ׯC_T%AB$KRly.P0oSφv_e<2S.ZC5v;JܷB]͑gXjVB(K\F( m Iq2&E[K/}O3Oӡnviwܵz\|U*ѵmr4a=%%:BH.WPF-.V*ܷ\d'2tp7W*Dqkj -wT8>e֛M֚Mڽ#p:j8ϣn(t}L&3 r{cea4?$zr{+d\ ~3>_'>c| 2g*rY(//II]$a8LR+uZ UIQQ6XviwSUUe2j>$ImXakg2LF#z1q|ǙJ qĭ[/~}H駟`ڱYIzKzgx79|r@QQ|>k*x]t@Cw2?OT:޳1+B# Q9C#Yy3d=FGG4kyKo&%a0}|7,% ~24 ^<3_b>dooU=4R=\O.r \y2A }EQDetIJh2U(Inx3{mOhVB6u uL:50mRqLesYUz}$BJ)JOZɇ!kݨFO:=5LRвmQL8[($Ʈg,G" iA4}q<e+1Y4m!-F4L˗3DI"LZ-1ur8u|KӰE\Bܾ ~;86 j4^& r[Ti, 3ulLl>B0)_q=Z{ܼ8N9Z6F1R.SUUl0m8&ړm,ץˑJA1JWɵwH3d2kk+Gq{/.?9aE8ί亟%SgFHIB$y QD)\|{gle88LL'ƴm:x ۖJ<+v>NzHRyvw\k,lo;BEI"Jl=p<0MYƳm^xON|&>[zo__Nss*SSrǜ;T<199)w̩xNcNss*SSrǜ;T<1-X}zIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L:!!* *!(J H#      H*K@dqyFܝѳ&H:' h@ no뛦jJ6Ԓ7u+U Ƿl9ו\{9LRͺ9e̔BpkL7t w DZm67 e)D|e4Y-pQ@b:9SYQGU:f[3k2sp_p,lPg&͟M>9MaF97 ~x ֣y"_iqx_Q`1 X@:5rCPWu˴&%.i>L82pdشB"MTUf`(ȄqscM7a!t+UN<}q #(h &#%0<+Ģ1XtڧuVYϦx$<mR]mmMm꺝Q]ߐܳjŷsinE%[6Tܷݵ5^g uӤAg9滞[ WC`pLNz8k0"0p@/{~\yn봼Ԑ MK#M/ (H$Թ%3I- ݯ[9i.WH346Ԍu㚛NќF®d,hLHVzʹEС:Z8[= lP\3@TTCb2fHQm4[{çN&R-p:猑*TH ⊟6t6jYp總ӈJ1qcŊN8d.(Ξlf0JBٙ{9j2&7mխv#fHw3fy5 aU%$LM {j>lR)y fF+/zi0(uJ 6f7tL wkv5~֭^cwo:jedeDmF;B)}b15]kÌm?:ؼ-w]oWk7[h!\@+ Z[.0y7W}Snrq81#17f;]S{k|TXE$v5rIW< /|ߖŦKv_^W[Y9/yW6]{pj5UsX'ԚΥjJk*NKk rHt^H![xrZAJ!9 .!(.j 4V@^PH'Q k9jW  !p@`->{l구/xZ;$XVyC-ep5j `@J@@B @]ri"0N V+E";01Ll3NﶭkjU-ݸL6.uȺL$9AzWs]v&ַo|'=b{=u4g9岽#Z-jqrA`M-; e="BIC^k I|ɥ 4 RoR\Wk ɮ/^Z摽VZ{KY~'޸QRrgJa62+ us{jsF)ZԳ)kMJou@{mon^No[\eo;iWѓV;w7kvqlaq(h|ݜfݢΊ0TU ӄ$Nۭl+,(p ((X-bXw]iTi0)G܌k߾ӛ1<\Iī}[;v&  L'I=TT'&#i6xH>068H!RBPlJ ᚋ,UTQPhXN]QVm6a4R8m4UL1S+k"p9 B@hl# 0`2 `Z 6)@8F`U&2J66.#9,8J"ӱ0@%pk͵& DP) @J%X!04K:fn95mԋ ]F- @tzԦޚ&JnuRQ!=Ӻb'Xq :v-N&鉝mꑶ657l\uV\\w]s2iAI;,0j!2@ 5 {aFϰw0taҖZX:6A,;*,l+ 7w{e Ays_amg{*&pIΘHx@#ЅD;<)ozmV+=Y4Xe u]qcP E!6aqhZ>u7^0}%Ib{ۺouۛ{%Ƥ%5/XWZP E iBKxfj2a%]|M_k*x] ֲ.2_9Jȿ9,&ō/bv"D .I.HHrE˗ IrBE༮tU(I{^&qv̗WyzI}(!řad-[0TvoeFm8GŢȪ|PSEMYؽRp\eI,bt &  Ƃ| ġP+G1ilRLtf/H{a6EOB0xpemCjɈHI]QUfJsjDhK!%) '(0lc:Jpuٱ6M[8lk$)7:YEO# E4N ؛.̽D`8*hE"!*Ueum J! ͒ @R)BL>>0By%CF]u7u!!'zyi. X/pyEǻ[Nŷ[nVu ·mnڣ͙y|c[vp削O 2ÝumQDURq ɢy M$;p2P1Ξ2p12bt 8nۨ{sQ>o:mk6d(,x6Κ)nuGŦM6*(J:ԖbjUXJ$a 2,P2>>*hU[QVquC2ˈEèUfuDL2ˬ(ǝm4Ρ>pR,xAhOGI GDM  "QHfFF2N:N<4+cB!ɱшĔ6x:"( 0pBN.>lI䐡>|BHmVefQ|R,pq19oMךkjׯa޼o]UGnQqצP6TM)8*$@Cb,8N&d0Q=סn9:6} (mȬ"i0NB˴uՑBhO8LdŌ61AJ2JJFD$*R@>28X|ldx\V<2FP1""'@`FF) HAIJ$ !Bl%%OPeL60"꧙8yЕ26 S0}Ry͛.m mY @+˂8 H2cUEmJ)fH0aeQQ/,s ڪ"$xZ/xL04,DBaƇ <J b`$BD ,J>\ZƑ]ex8sm>Ni'F4$U@ET(i4z m\&l=&P2{ka 4h@H# F ,EBDbVyP$,"rKMUEHE2mO.1ԙ6nt`:&d`0@iOLʸ. {"e NqZ2«h҉ TH" DB.K"a$,p ,&H@ PcAXbKU.l),,$1x< DBc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$=?kE1@ज़*@?W?W?W??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition3PNG  IHDRc IDATxwTE{f`"1qwuwAFP@W1b@3f#**&dAP`D]PYaBz:LwO0Cp}zn[sNT`T oO7 . 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ǗMy|±vZi k+ LT5F0ok9XZުC,vG'84P_~4P0fu%gl;L;OU\g hWɠZywePUUU_m3"+Dniodߡm|-I2HL#Ҍi $[,$Tq2ztX< #I9ntu G]ϓg MG鬗n˛(κнΫθvOi`0Ӹwvљ5iJUpshDQ0tEg@ʊԱǠjyVCCf}rѱxí{))J)).5tWh$H- U54ŝMӠ 0.v&Fkܞa{d!^j2|$L7a'F._KWwc{1a2lDjC}n'13Pq5FL UUwΜ-8m3ڟ")hU?a5$ك,{r]3i\5luzd?fP=aw2ʅ]Y,N8e~mU'>C#bX:8p3p3y捻= Hۍt·`dT}!Ң;vXO]]lTfz! @" !?mHH)K^Ї>TUT5ER5MF I l c bLf]$GZYv:sD"?`l]zr ӨB 䟑TzC"Dt4 3RXPSA>]Yjǒ?4 S]":19&+Q̮P4\aKT4=_D4k HTvOx! ,D%9pppY+ȼh>sTC]Π&x\0BQ< ӈ%QMʵP +%fIdX$$T3 QY v%ԶA"2T<=IZwD2]c?z QZ쮻K5r) 6u< ]Z~HCw=[zj(ppy<%uMLEyZ&?Q[FbؠcVDB a!UtP<>4*jRZugmDJ zJdm͛ʥqB8v\2e38g%@c/O؋ab].BpL['޲?)9MW:&&&UH-cP2*{zܒGgܜK_3؋=EC_$vH-(pM$tx@cu5fY99Fiї)'3>A8Ñ~&.~L-(KFɫ琼:A|1=t]Nm֨V5;B015KJE`l *D_Bӯgې˧B3e,kf)\<N!cq`/p&kTF04W@ p} b ȉecay槴5 uK=Ȳ~sWMxh[!,;#'T̅Q+$ E2uLV%*#?GKct@x`O,̷la@mlRAŁ=šMa:sWq DK4`=Ka ~ ׵[ۻ/*;4VZu1M#=бpaPg.w7<(T]Sn"ǦR:Тڥ6B%Vokc{׏VpLN74 |)h# OnND#18 O]y9TyDQ wv´E,ZG?_ߛ>m!x4?A*Cp'8G8=ߑ<uAW~1^c>-q_ၕ*h :x]־2Gk];08d-Oa(\ƹCϦ3ݸ<֠[7*RV.%ڷ BBeqr0zuMԄB^a${(.\ .l؇ <$C tʢs5K+J:9.n,-⾥ dF6k Q37n@Ҋl & fy+ ǵf? (F:AKc' -8!_n&gPx|ˋ00tjf|oKc(S@.I:7Y)g`3ܸڄFNm%jEJ!K]Ԕ9V"Gk|$]\@Sڒ1RŖӾzMV4Wo3^J!L؍IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0Lk!!k !UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP(  jjAjU_Pj jU)"?_oKR?*#_֡_֡֡5(jZE_UVZU?PPPj֩?P_JRPB֨?/TkU֨5j*U"*EO/j֡_jB $I$@I $H $I$@I $WW WWf#' c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???$??G,C4@!C? 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L='BپN@<ΖM}Ovkݸݏ'Nh=>aGz4UFȯ~V{ )oYhZȭ?AM'GV&xu}T^ %pp8J$%#Q[9ydܶ߶CSW[\&jq*m`gՆV(|R: Iw7_u'q#b_iܳI$ecn'aDZSypK4Қ?!4ͽݾw;fZ% 2f]%wU TRMAl\>壈2'1w7zg 0 Fd2I" l_ɣka`۝؎OpǶQ=2UQr>|ֹ:O_K]{zU{<@ASpz҅¡J&=w2L00MLbI S!i۞?bF`\UY=6"EJy#Z&ێ i^M'=VmzM 8Ih-i}ϥ ,c/KIOMGFƷ߶jȞepmѧ 7OQ[/FJIi@,F$Ҧ>|}۲=lbHX[/+)W&ͻ>{F6/ٗ3i~m'͔q r*?;yBGX4r>XضɶX4r^]'*@(/Tae 8i#PaPD/Y y?ׁi[|?bK;z0dt-mvvjh0r HiǛL84FjI_[xkZu=󧞏@AԴ)Egk!GU]> S3A"zjbYg[4-r=kq DZ_cb9g"odUtχ)6ww}w8|%<}OGsO<'Mꚞw%d'wx[6}F ;-+w@,薲7Вh$o`G:8"9S@wʚǼdeo'M\ц?ݻ+.ՠϙdwGuO{;;wļ:?gdzϮ ngV :-e;B}O1*؎Hɣ+"L+.z: o0ㄴ0O[ !"L<-mr?ܜ.3Y²7},)[6⓯L3.FU4oZ=XPF-lG(ڭd#÷Ku 2RŬXr+X"~iݶ6_ئ#'[qQq9@H\jNy#M ylewym3}ƲTښr4q1P!!-i^[W}#|sK,A 7EQhjc޵]zGY7dUإsuq#3}boI`p(.(Dz=ۇw%ެDҢ'Ͳ׻Ưa%%gy?F'5|3p^97:ߕrcaS+7z]'r.#p<3'-%.:f{W,tq]:, 5X_1Npmn{-ûi&]FBt7NNv֭s%}t***bnGzS9tXQ57M|{ʥ?˹&/ Vp]GS|xben,d3O8yt:}&EqQ9H-͹mѶUWjAt|Y}TLò LXO]g93Pf'_a&l}?kcƤ%X.OkuÛyRPk8$8ݗVp TLE 4dݖWB?@J!1;a 3u"K[fAҿUbzLv%ȓ>2ZOh뷾ʔqxq>@Oܚ"c#@NY%/#Gpò7((kd[bΉnW:H1e^|3ٰ%aی:}_*_nמwDaŸ _yXɲ׻n3j6Tbq#%~JuƍξmAPSmAuMH+uθS\>隣DO1c "%n4ҽα@҈IO0h|/yΪ XiH6ehk=A:?i8ŷ D2r&,rmHkG=ڗggzE ѿ F~oa/kFKX2j^}uƤŶ𷀤WH7Koe7?üyAQ]^lݙY'aYfକ"sw+`qlwdBAOҀV3ur,t-#)-.gP s~?H μ7=AX!adSRΓl#XJl뻿5v6c| 7۫z$<[`g F}OK5#?!5l"z#mgO(lS3<1eA@*ʇw̲eqlli ImǛ]QJۺ=Ai鵵 .qU[$gI:A壃6Ͽ[lugpGMEFGځ!T)lok^w]86DN \Ɯ7||ՁRZywhCx |Y5U]>)˽kxӗt8!qsфɬS{ҡ=E  R1h;6y6h RpOq{C" ( #*C8ޕ2\> D~lJ>fH9$"%,E)E^ꮭh(t­ g׾5¡(PAw} M ( =n9i{m9A4~]yDzv, X6 Ot3,s,hĶIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L]!!k !UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU( jjAjU_Pj jUBJQRTQT*UDTjZjjZZ֩5TQZUZkUUS ֡Wj ZB ZQQTZ_jUP/ ֡I$@I $H $I$@I $OWW Wf#I>IUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???ڌ$??,@7I/@@d;G?@6?@6?@6??@@@x@x@ ???333333?333333???#~j????333333? 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w"{/筿lb Ky(mG:n[vg#e&0ԄR)) * Q^>.+#n_4g ;_(`S4zTΑC%-Q2}~;ԓZ!^4vxuƪ9PdZ)w;+F!H Rfgbu{z{cXG47db S0rP{C_Ox^n%3o\{u0Sj0ڋSDjgi&фg7O,Oo2Ul9e" Ź'_G__ 5h?ƶ1o*,d dU3-KWCSVH&o?`Y&ouktim" q@N6o -{ e 0"$afSU O4?AF !2H@Qǥ]FHҚQl"eHYITrԝNjʲ:ñu+dQX .)m(‰sq%iƱM<aʋykovDzehy%鸤M'MlٲMrܩ"~0XHo %ICmӈ,^Z4D/sd,iZ$Sa mtyG ȹ#!>#H۲UWRJRVf0ƕxtiۃ\tM`nVg+HB¥uSu rB[r6Reɐ$Qɔr|LUHiZ "wXbO(8ːf0G`K4:2Un ix=t3l]~!dph/]-[c>oˆ r]U|s%so}, xxMmFtKk8:6LECJɘ &K&"_6 v/,ۢ'N,1{\NXzCb㔍Ωu)A[dgn٬J1 G.V4M'XRDIVpGK%ds?skJlHۡ*ըBT':ʹ)kO DJφ"K'_!N̍׭i:(vC5>iKkf65sA~zRf۶sH_iooc`0*%%RW --Zzyl/ƒ]㕍 HE8䛊vX"eF$Po5lw9)尚*)dr?-9ܱ͛hڇietY0k5mUQ*aJQ~  3+u 45O ɀeH)',?=m%y5gmؤ_˻OiIe^#fҶLJ?tq-Hxs~8 s%ʛ["hτQ͜~?s%UZF$%E$6o~]1F>^,uҸ YDwF=TM"4c8V%bY^'e_ĒG*˦R1}^)^j1{2z-]iRcnj\e[l %%%TTEG#DcmGPR'5ռ"ĴrhJ4yJK8oGXj\Hi#P|(+s5DW3ߑp$32;^OPUSR86Nߧڊ$S1%%ABe|fGMy:MݡH7nCi:>_ɰn Jdžgԅx<>limo=o:L4'nY,좬 7n`dUA`}۲T^Ɉb{ïLR9kB`ۖ[ƶ-Z{ Qc)/ͺ,+58bϼn#T$=otccl-@rPe6GNC|}^3b |1.4~tOqw4URi+ژ jgS{gr]C>T Px&Z`|^?Bӱ nWIƲc2N&4wߍy7I>Ыy N"n[tȕreJv(Ѿrim٢2@).9fDž H#u;AU.iZDzy'gB2=0\^ qf/cx:iRf9!P'/ xm[EҐyTОxnkǐ>?>%c+!('/}>|>J$DcQ>v7-!+%gPH$ k<ɵQt_M7HUϢa\7EI}~mcl\s-)3!+ө'.RClOO܅H%Ĕr(򾳇'ֵt7NBm (i`˂ʟ-.>Tb{i.QT`w7v?-n҄{+ )DN7:nR}W?ݖL,lTh4$pT;r*/w?RVZM$S.>*n%f"=t$ዿVйtݣ2Ha6!H͛rg e0W[e&{X謜ylo_$N,B4urԥm16wmS29{x.O}l6.=4ݱjC%SH/aM3A<5@Vw@Sѕ6d*Re۞x /<!<m i$Rq:/=S"_i\"`Ȅu+bڔy9j̓wpr2dV JrԸVNV*PnÇ԰`{݇mOX Tym4o~J);5k/97rc;2h]^O(XIJpg|'msvN?m!O!Pm{W5 t8ji9Ìʰaٖu,V^Gv |!{<axSrj*NfgFJJS |QJGǛP.,;mŭfr WǴ$S ^}Q[TE$O[UhU';w3_w??>{e*`T,?6e烄C<վMRfC ҵ`]7XœTn V5z9v>:V@ŐʒUD`7;lbjq9马nM):d*tCƋrxn=XxɤrOwlnZM[9~tgJ%фq߼1$!?yx<H?nW.T"lA"%jCuŴ2rMcC0v,K4ں+)i+m  #$ t 5ӨR{aXl,=MPQ/n""l<ZqTͭorFFyi;E(+zؚlTLGf CnѐHx2S$%$%Dx )EW!$Ғ ?6(l慧~ OSxf^zyP6US3jE"4EMxt/SguϳV^YyB9mGHL3dMMe 4-tOttOnDHE^"`7SQ;F=}O41@NyӈǤ8ٵ"ʜi&BQסP!DCCF)\ZW=N4Mof.oPnFIDATqڊi<ئPƺn(SV_hBreT)aJ)@nODakek*Jk@ mtc A%Ayyp!0.8uZHLۺUm3q;^vTU6U٩Q,QSV2'hҾu!фi^r&]9ضCT*,X0|*ZtƗ¦oZ$XlbgPƦ2MWVsqV4yfL]H^@~&5{p3sgf/^WzX`4@sӷ/Qq;;Ʋ. e~HPtIo APAХ[? )5j; yξ}L}c}N 3a?9z'6r{O7N45O"j5e-|Z2*lg@ыƲɒH\R]&ob %cẦZO%K%$kCF0F4mE<<>Y& vu;@Ui !G[3΅!9qrvrym%`|]yatOB+d/TI& 3q־ЊOyNG)`|U6 U*U}&v{w 2R*d%.}79w_k݄VXeV40IL]/pg?v6m-.-wAܚTp]tٛت )Lj%B>a_I=]brCT$S8~餾Co㻐m/KS _-m,͡XZ*z?>Gӓ](Lvmeۍse*oH$dR9R,WGosL=Msog 5ámIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0Lb!!k !?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@( jjAjTTjZUWUHւUTGj[?KR?QDk/ //&ERkUWQDj#PZj֡֡֡/R֡PUOJR֡ZQDZ_֪?QDk/ Z_jZPI$@I $H $I$@I $H 'W Wf#?3ꪪc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???unfu$??Q? ݴC@QC?@}?@}?@}??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4y1PNG  IHDRc IDATxwй{F3fsF($!!BelE,^xkp]8,Ys 0 !4JttQ=34)uP5z/J3,EB"EIuĀ+p_"sʙPYHgWW۾aa?_| Ӈ!LmismE7uL3nF]H t]c+ђ1^JXϦ3 @EthhOhOhOlzodفnnPpndHZi΅"+\%Q|4|bnUq:(,)]5 \NBL@`yF٦#<hz"Mð4d%#d<ڸJ Xx%QbbM>fNY d #/ (8wҋ`Y5 PsӦ, Gэ$EhhA5H(@4C4> 0w7Y{G_1}M ˏ q%"9f/dAHⰉ[,+Cm\kq.\h׀kZ;,%6Izufin R VWGU8T'ř N7{X]ҋ铗릵pO'A:;hok=6Ö+w S-uu98'b :u]YʊdjMK *lk(q{p:=#\+>ԑq/rӆoՏ}9ԹH_7sҴ~IMGqk_n/|E UG$ډ+tuuљS_t0[hla{^@h4'DUdYA[^\̈́⪼\A"9DeUd`X!!<"yn7o|k'(9YM #mFЫ1ie9d5,ً@$wHu{:) mbt#IKY?`gk}IƉ%;%գ`0MMܽZ ˅iX;s3`-6|8UUuZ;:R3Xm,+/>_e1zn8d 4kע$qtS+Bkg-h 9qU[!LzԷd~"5%ҋپ2CBX:uTa(AROֈP$DȈx 0ҋw~6ZoLJ>O!tgOV#c /jQƾ'3w}ӬZ Yq:8[ (%HHĴMGЍY$X7E xپkȊ~iHG:i4S6N)$,3l)GؗZ<0udIVߖCu!!ad`US5KnH (M{t(i~^tM2nh}.`wZk( ?7~d2aڳlC NC,yhˇ]Sh ]O;f̮^ڽ$z>:kClCBj?(PN0ܚaòU%Sq.@3ףּpkӣn$q|pj]?W.-a RY6Ӷ׬O=A}TN4 ATqpW8.zbt[h6lp͟h8[lf=⒂J:CM^T_r9,zR7Y3&gksǶʲBS/?<\F`q-fd!ttBk: k6 EWSo~oq?WT3&/wb$IЋ1\:&_Յ,#[eCW5m(!e22b0 -6{-S Css:\aIijAWȲWi'"- 36Cp`O|\&i8D]4PY6߂0en?Y d g M00rZԔLug"H"S/ #63tv75 fͧ6PTC0uŀ<lb Gnc ӒH ^7 LwR[j]g{(\[E 杇mIsZO L^E2<lbçq坼t+V׵|0&s.;L(ܻÒ$o.:~;sB†K?@PS@]MM{<>d~f2|zJ +)+La+"`ymo6˙X yR&)ȓ.X5UsgI]̪ev7!u̪eDALLR(K_𕦯M %y wkqAFFZ#rUDtaAo9̞dZ;kìZt=hkX#"B8F;3mXa+gR,a33}톕1 r!k_á:{(.  "2-UPX~" xKP']dY1L.Ȅ8W8^wkc97twO{DȮ n3Ԃe%kSHD@.A`oo8UÅ:x5gFS]1 $I&vR!Ŧ5i/SY v5:izP!,UᓻƤ+lfv%^/p:m[p`Rz=K?΋g 8T>:,0iKXK.[aI^uӴ e-0e t"9fK A2ut#ĔYM&/ꦆ'p:ƶ;%S$LGOS?`RH 88Lec:RZq>{`>RJ#mvrzq;]Jfڦ#7}zE,Xqz fFq@}tхv鎴l$N1g } Uu#’Zz:qyX~sO^lȒLYwpW$ihC'i%z(.v>㘓0>g>A_cP7l_}<kK/Y~);kPeI=Ak8g9vڒEaۋWcBq-,%su0MwcJפias|XRUG{xmӦ ^WHi'imog*@5 Cω@I#"$uHX"SHLs+}SUYݖc(Ɨ˹sD8)m̛ 5;DݗVeZk ˿< KgC@5Zgˍ)yH48z\t©"ԾOoQ%qt=I>1׀Ō<_qeqڎup([9b˖-<9 -ginl:*Hg2Aq: uVxa.72L}l>o 0a#䖐pp<r o5cΝiv7tP/C%;v+LQ`X<{]Vv؁3)RYzRGgwx  %Ut YR{޴UaV,)IG.vE+-sO,kaׯ4ӻulc5 @a yx';w.gŊiœ;Omaav"ev"E !GBٛ sS/PC_{ɭLƭzCOeQ?(*HI`"Rk@,t69dP]9hn?,HݍLGlaiڰG4[ȲLid>B#cz)V.d2AR׈%"￟9 U+bfM`gҔ0$_im:IGOyCƔ<]f ppU4IDAT*8x+J̮dX3/OE'e I2ӱ訽z=3gJh;=wܜg=.?meg+A2Asi#5yV.4F?rz4 fāQ'E<`OO˦aq>Ib͚5Cze|6UO\>7x;2:\yNsfXk@_O~;p07pؙّZnN ףxE]\_o?=;߹;v*NtnO>t"wl;,̙e]At:$I|wҥK~^{[~M7孍yW-WmcPPg[cPuď~#xb/| 9\#wޙ8OZE|ǯ9|cnC1_<" vs{諒`k9FGH Hm_y0s@uA z~̙ܹ3m ij ZȇK.>KnΝ;3L\(._1q/O^w\#ρ(bgfΜ9~xu싳MUGG<2X'Npmd~?i(D$Ιv2sQSLM C OYOroPSccﵙ9x }^C<'Pfʼn,ܾk{`OY2$d <}lVvO,l2:;; ݻロ^9gyfjjjiw{Grno8n8 X'2zǭ6}hp@`g`N%e˸'әӔp uG}l#i8n$xE:6>"? =yRN2W֭'H}eŋy,s7tIcaߋ9UˏDB҅嵍qںp84IʗgO >`p W,$Ӡ!S. bE0b!L(nˏ hϞoF,wA(˗/ka{x4q xdJ1n=ƍstp."=|FKnaR,cyQd <8C4o\sx>vkjjز圐y}Cˍ"ܢYW"IX$/iS UqP8.\Noړb$\p_{myuuWtu..c1ĹŋgTǡhfQWW_ӧ׶(q;|ałͨUqG5zy^~5ĹL?s`s=GSS[Zb"ΤMnrWU'eŎ m 'e]]ѣG9z(UUUL}ǎ{|3)M4i`?u!c̪Z/+fG&r,i7x\7ԩSumz[~P3P l T`^Q{ڵ|;_ q+BUUU?űDqaP75u8QP30ZyW=_XdI:cuu5k}X<̻GspΛ +@IA9*fQVT4yW]A1='mi7›V<@~r?VԓWj+lN GBK \ +?ܩ+3 yyWPY>ItxiiO^7Pvá B_Cx~n6|2}cS*+ .<Iust;cp)Kut;R1"KSv +ТF!\5k>ͬeȲzFm w*"IҨ |9S/Eb&T%kƌӃ'P/.(32 r.֦w1cRTPes7PRXɄ*"4-/lނBv;/̓O>ɶm۸ˆZ?VXw!D|Z™WP+ ;Q]Pt+E[QUh7qwe\雄vvrѼ1gJ|&OaB\/^C5±.N;b)\(X4k-2&OW,"^'E9pլ^paƚ8kvșij?E$37wkAHײ[Ftx(RV\E#OGݵaQ]9_);c{^PZ fں tTV,SU e)7m}8~]b 5i{䅬ʏO[11i么Za꘦U:s#]ʁ a:idaaP8N40>["`Yb<@ 0L%eUnuq\7} Hn1jYђF$(Q/CB&8zy.2,s2$ q\dvW&xS26!O_3*q#gO[G'8r8yƑ331Nqq#gg9c<G'8r8yƑ357=IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L\!!k ??!?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU(  *DTB_jAjU_Pj jUBKG(Z֡ZZ֤֨5MjG֡UVZkUTBBB_UZBIZB ZQQTZ_jUP/ EjI $H $I$@I $H $I$WfW#c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???hh$??X)7Mb 1H?Cl?Cl?Cl??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5$PNG  IHDRc IDATxyt\}?w]Y,ْ-yWp7N7&NKH(IC:$=}Rd9MmZ MI l.۲-Yoyw3W3!Hsy}H O3݀<^㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'k㚼x&/<ɋ'Gg2q (p23݄1ɋaR~7Myנ溂څQ 0i+pNZ(|4sR[nʅ fc,^ LJz0-4u,²,dYAYai:8yIΑp`$OfܥU% IQEVϲh(ʮ9nY?_uA$6D,%G1²NTECUhU9Ƅe[@{Befu \$譈)\nTYEQU~w5.\@UU"0hHt&GN c꘦棾zHJ<+ &|+G`ӦMd>"J7ĈyAm囉a^O(X 38G@';N{qp蠳H 1#"Wo.g=ŋ?[oS.'.G! laL@#p_{SOe虽ÎUi&ؽU{ow$,W把 c N5M>`=|^<"(D4A"!|d`[n BXx#GN8N4v}wFط“łPHr{a```Zy4OFe4?8˝7<.jTE%b0Ow+N8O8f.v~uu X|AW~9,Cqs7[osey6+ud|/ڀXp/[gAq e(㫇z}knhhmOB[%|9-;w-T O}StwwsYF[x|;ˏ[T1URHfXzqE݇D}1Β?ǭ:9ĝw"qmnI}B_^z+Es瑿ekצu?g`PHğ27܀@|jٲe//f\0#ţ;9,Z Gyv`0UW]ogjY89Ou@#r~:::`ǎS0dҢr&U2Mt]Rk9s͛7wv8 X ͂[; P ]0 cųj| 2Xpt:{39U4Mc֭۷x6osyf\84gZI)ޖpYG&\pP(3yzU}Σ>޽{s/7.~L7! P10c0mf|D5?8=شWSBeCVgi2888MH ݄W#@7bv,s-裏NpFrOpUppLk{/7̏<4z=~TC46Dw_+3/c \xf~4cmZRKX7C$:k`[LK-Z_oi*Lˤiowڵk9y$---:4zso o0cL _7R4MT6e tL[#ywhkklŽEL^/:0`Y8,^d˲.kVL\0Va ޷eZڱo>Ν;7-u]~;7||cTYR0ЧA|xvk͌vmK [4V\@ɶk'?Mc9߼n|>WU7_iR>a<I0-W.YJ8ҏa꘦aꨒ,;ӄY` Lw/_WD[f[~Xe^[v O= :GiPw>o107ߜwʆ1%"@"/² Lt!dy&;s3I8 &ٵ,,nY/b[ρ h:"kvk޷o<2M̉'\~э(֤j<EqșC_v#MkD?cvsNIׇ`st4',k%pьsI>Od\xo%naq>⨲,cpW^ᓟ$FVa!,>X^Χ[[]я~nÞ=IS[[˒%K5k 5b K1M>'?1f=Vn@Bb[ɤ+WL p˓ˮ]z{'~e #ICݵc'K2,#c?g:|zA-u^|a ɬF瞷w~[pB,ˢvlN(*# SG7cx.YQdIRDfɭԮwTݒ-I&4c{ӟ4MMM?ڝ ɀ!6q'''#$,*zeF @Q.\,)Hۧ^˨|xw z;|_glڴ ]1 {"3?4/ 擴L[E3aE* }Pd|I'MqH&:)[n}RW]A0_x8ts̙RƏt#s1i]$ g;.a {5K&_3cm۶PfAu@85 (+i!GSh{P<#|o&n/;Qj|nܱ{婧J SBrr I w\9HȒ,IFZǏPVV?Y'1?#>/ϓW\\Y.绖%xקv'/~{O"q={,lܸHdԱ/z~G,cߟޔ~sr>˒9%G\+V"KvGK# )Ѹ/ٖ$s\u)]weG~kC?êUؾ};qغV˿d6w7RV\ЍO%q\˳hDzyI°-a:pt$,d6]meGUVuÌ{<ʏ^[j`saϟOOO+~|ر7fLzBj<% ׊T+tvvDԀpc$bkc'%[FVz?N{{|{Ns Ş j 楬pE ,hI:`Ņ:9*.nf>z*fװpr|m]M멆OK0q,Ql9-NjO|YYY{5EP Ii<Ò5,'3o$ EVXaT CeWP{?I|uױdn6nճ~3e5lK+Bpd`g.\C_@"TΫ'/ +ro,+,ϊPZ4¹/%޿?GeAɱcǨiK+)/]DTuV=qko?+"J)+d4ω R13 oO~NZe4b9^OIQ9MDH"1#D if.lBO/ɘ]po MTL= Eh<yk칈GaYw$5w2cY,Y 3*i#, a}!8pӒBc&ƙ]E$ҏHKY]ꌄW*k CĮAEʹKY;~ Mg>[ȏae*Fu | %s)+t‘^LNLWw}9+npB4 r8R<<{kvy"FE^O$6ĪeW r|~6Ӥ*VP,`.Hg[ә饗^kf%U-m9'yىli?1PZT"kN86z},҂rJ|乷bɇXpG{z) :پ>۩R̒k9#Z ,SSY^ogpJ ˑd4ņ ˙XS@W$K>+VP*Ų,Ye/0EׯXܼYpZcl9U%K)ܺW`HI@Ia9$c: aѓ0ڂT6p_"QYS eALBU t3FS+\vVDq\Ǎ-}/b'"aU|?ţX8o9\4zژ?w)eb\P#LE&?[D0^oж@B g|7xKr-S4 }֩ %Y7Kl"ewDbzM8ȜxfT`$y^ (i=8p҇Ǟ]כq듕'-pWVg+PUqoU-pʲܲR,]N=d$;'=&Ϭ ăygUNذ&Uνz._Fr|ܥ}b\U8$bz8immXz'L˥´܉Nl;AQhvbA3x3nǾiB2-vOx29 ENz's$p: xY*b_ uaYOfg:`o!HꊕȲlg#DbCt^LQŠ۹%\>9 ivs!,>b1ہ]'P/yeۡJ*hM*޷dtw5)DR z(eYNL;v!#&jDbHtEYe)$Sҡ;eX\0ES= G% r\fIRQ)q칕 ]W;&1=B{y׍Kex˲K"- $˲rќ5Hmd%qJ,0jqU\0UQ15U4%:h>'hڙ^9r(odYrfK,N8P3HNQhv"i,^#j̭CU݈ZH&NqQ[3YJs{vӋ߶R/,0wY(S km`Y˨7gזr5B@8gmdo'n<~h{Y_±o_KKvvY` #,+!#ey1㙙'cm^F$*=J\ pMLZx_k?MqA@wob]`n;))ìrjۇG;E2JJ}?zkEf5qœ $8@!%r.t!վ]7~9ΫoX,iV=y5Iqe^O`7wҰj9q_YkT(),R::/[4~ CBU 2Qpt2{;(+.Ǵ,gc8 a *.nyY ;szT"B!o/Y\`tŎ!.^OC7 {y[wɄY!L S-\1<JG()Ky٢GjD_y]SJj\PoqBb^?8ǻV|``R>;V Q,%(ƣdT^:̟` r˜'91- Mmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0LS!!k !O( jjAjU_Pj jUBWZ_֪?QDk/ //&ERkUWRTTITQZUZkUUS ֡Wj ZB ZQQTZ_jUP/ ֡I$@I $H $I$@I $OWf#Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???dd$??@`=M;@s9?@ve?@ve?@ve??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6 PNG  IHDRc IDATxy￧{6}E1`\ѨQGcTHKb5}DM,}5ј`! 1&B4⊈", 63VU?jjfff|:uY@BJlliD*Uk'Us6RJK+YW-'-%RlijRik>u+=W)x/ytO:bP^Z&4""F J5J(m^ܾ1ЉDJرgcAh#JĈemm![Zض-Mlr6iR߸p7s '~-3bN~:B–X?DAHJ2Y|}IiuAsCw׳Eg޷ƒtȒ&ƲR=s9]tH1̿躁 `nBȶl6IsEq# Bn,G(Q"F}Q>~'ٶ=,rLw[p{aaQ4;fklJΙ_]n^n^mr9bOD*Ϣj(cRh7o 8H"D}^`Oݶâ9+\QoYIK_NaZ)_4޶aj>-x:x ~-Bhh&44MGtt`;tmV,d_.reE!h#F(Kt&mmu ]7JD Ioi?1{ڕ"}nqlo 4,_X}9s!R(TM+i6|\4]~Rb9q fㅵXT%rL; k !Ǣ+q#%JH_D_"M+ GN*7?>}p//vsܻ)p5&lDJ۵~),;[܎~1I8aTliO55b0'X/fJXvP`Sm1j v#XxoJo^ɛuO6ī<|VI`IJK*B}M|!BfXX好)Uw%-C ]фKHOذ^SJ`wMv˭w(%pΟ='>,oxXvindǞw[9 Nu{cȀi7pSBk`wBpx )3NLbYiR̘8O;rƇöM4Mw0X{⺹w)w5 #f= EJC7@VϽ89~ĩ(%{̖k᧠ke}Jb2^3bBrIgLI;dx#@W,QRIfT:Q{ItX<奕vLmS?8&k*[Z*VnǞw1'+ `ˎ:TlTƖJ)Rx.8s%n!-rz3u~Q`? df@1c?2E֮(`:d ǶP&s?iq `9CfoR޷@A듕ࣚ$܅3ij]ш@ ' Fʯ^3dcQo'Cfz(“SDzMPzq2,\KќVn^+(3H%߈LyﴊiױiIdāi"{c[ǯp+uհiǚ]wR0O򄣔9iΤ.V$i^%4|zK%㰧Ξ Ъxc´R8jBɴ =V|}X 9OYio3F1z]#NqvkVZ7!]JV7B8뷊9Hp'l?hq`W?/o};SHvxꩧ3gNQQ HI:( s\в3թ ]vΌXAZm:^e|ǽxqkݻJ~_g\$ ,¶ml&NJ0axi= 4RꨫcΝxyg]EJTJyg|!?xqfTEqV<';]˛B;2sa>'#$-.W^ 55s/3e.]Jee%,>s袋4 04i6mbذaL{`Қtyݽa1K'WF@]npj.0J`beqKAdXشO"_g>3 .!ͣW]< {nP??Xe}Hh\g|Z; ςXA TX ǵomX1g`Q鞑8$?da䪫>K}}=_b6P>XUYUU\АŻ/")Q'>X/'w޼L)"8eYhΚdCLQGPOdjt)(5Nχ?Zoo~j #eGL8Gٶҏ2|9ʊja0?K_|`bm;k?tnf}Y9EגT?Vx >#coFk9PכgN4d|0wO`ɱxȪ76owyxuK,WUWU 7g TUU٫4érdV3,,M{g-h4}n#@(6k nÃu?XldĉviTWWt6o<ƍK>5а+$xZbB~|i0aCt:/+`&O+=]`s]SgƀNj[k=OZtA(C{#}XM+xzm7QҺ022?WKTЯj(’*BIYp=gOOᨳ<_\]30tMhvZ8|)(Xj<\sM-^wEtV-#ߛܚeH = P'~g;>H1jĠjjH1?A-u};Z np]u+VbѢE\d}.`BJ ε!zAccaoУ3']yu,Yc2f[l߾zjyW6m74Eey?} {;rXbr 5z4lVfH [HL8uJ)&O4hӧOg֬Y|梋.`Μ9~woW5+Ꮛyɿ6^S^>x js(=S<ѻqwް녬=\?qƏmY/gfƌߣAga߄w‚iyz\Ґ'843nEm۶pBrzN5vm;΋uAYٱ!Q`jkyh4%Q}x9XV868 7 o>_eKVUG'CGS2;@k~;|ӓ=̽{US΁Y*v5ȑp(q8A"@d"堝 `ӧ3rp랞7tRJ>H-%O74p01v;z}mǺѣyM`{'#zn&Xf ֭v/o.0rUsչ\A~v'ahqEJKKy[gfǮp[gN]3^:m1{ڕ{ҋM'Y9۠O^ mGo;Mы/$)ɈҒJI5VDzm4ϗ^z)&Mv/w{̘x!#(]W"׹7ʉSp s#V .tRgki)P4>Cl۶nݏJt:ԓKtNR]A z?:jv:bybocDeaZ&e늛Xi͏ڢښ()O ՄF>+Van6L1 dz+ΚAwXEt W)/O#AJeX# 4m7'lmXv}=͉Rhq,bi ;͌.[t: /@F$-s(R(%8xaΜ9mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L\!!k ??! ( jjAjU_Pj RTEJREJTBKG(Z֡ZZ֤֨5MjG֡UVZkUTBBB_UZB֡PB֨?/TkU֨5jZU_/ B_$@I $H $I$@I $H $WWfW#c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???$??O*s?@@J? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7;PNG  IHDRc IDATxwT9g^Xҋ,UEAƂXnzɍ3TscLW5Scb%XAEDA#>; ;;((kvvfs|yoQq#fUȊ(}B +Gnvh߃,)Hl=@@Ɩ=CqpI=^ I2,)DpfN<w@<`68fx\Y]YUQ\0 tN6|MW ή]8GOa6tʋG]B0煷lo>JS[F8U!K2Q!¼ ˁ;ϳ^@$.)u,}HEz"O2},qL>,oEy~ AV/{=K݈$$$Y>S]5R,)[<|蓨VCIpP?$_[n\/v #fvpN$ɒibque*~a)1 iRZ8WV=GAN9eEtٺ]Je!i&MS(EU#GyfM:1dyrjᥕf3U9ܬbop(.:sl @M}J#@d$0-pIju4ʪ Sp̘o?Lp:ȲB ƏCjJ F`bp9<8^$!011ЉT5F(UF5Nٮ=x9,s o{ܬb: (_M;(ayJ~eEVh7?Hkg#Yvi$k4&eGh!dXX6x.-9z{}cL<!$ 2f+YRP$1 3>z9Gyr}ETAڛwU,ohah@^v isE.@Z}BR=\ͼMkG#mMlc`bZ lSݒ&6س9!? 4lo>`[eVB-+XN788/p8$p4k>gPP 4(y% J=mdQԌ?gĈ#q [ٶ{5/diZ|BwU [aOkɒh8ғ>ZFc‘7-c`CGyp!yŔ@:Z=f޵z4;(E5rf<ܬb 6}R:'L:vne<=jij-IdKM;4MTUAedEAV,IDNVQZcm7U#%]SK-->S̛rt]Ca?V?,`T-Gja CC4+lCԹK}}}THGg o7ƪ ϥ}|L%U C6Z *JFi"+ ,1tؾg v;yNe +I을nD /isz# @R'BHjQ DUÍ,)isJSM /Ns\'ONV!wt>t#Јɜ6g1+ɴn(aoeԧE$ 4lܾ?=̟qA8+؎,+BA($)|i(Y1 U*N#ElAHV6`dt`(΄87 ?Φ>{v LIt MyTY1CDynI)I3W1Z!b[W7<͔m$)5۫~]uuIe k=\N/nEqo`&-H0l,;2 kA !ѐrˤaMӌovM`a?r6&J`>>ڳ: [,Aue Xשa`Dv"=5-͓\,E'qMu_Q2&~'>dف,ȒnD!"jM;8yڅHL$wDPS@U`Z(. s+hf9h-Lyo:Oˁ{^S&)$lr>͵Ӓ<&,)|㲻0M2gy `XP42L__7 ErlOL"t_HBAra@3>˗7.M" (3 Bo''@u4MCӴ^UW#m]$o\{p$С2cv0M{x40LMO-ybajB^`e&hz_- gre^DӢvĬ9¸P88 EoqqESRRL~~~v#Ə#5Lw.ōƩߴcP EHL0g׾o:OC(z UkJ;}'yWJaf+sJzLFC=A[TTHQQa@)醎g 5[_ 'N"БD^N $"nF\Mb&pX@S?@k+sEQaØ5w-DkLuu@1"~B T߁`Ep]Vxqma04]Œg"I2~L!EP(Eyi}#jW}~ ВT:wߵ?e~[b*n9'#Rg k<QN:c_^noު0v彍/0{9hZ rʐ<hU Pҗ).Uy\#hrz;fґ!e&!G:$$MDHENͩ,c0tFUN}PEÛm(qg!5DT̀#gj>zsv,g{0MKuΦco)+qX[O/L0e̩ȒB0܉iZAGSΣr9e<m/37yY׉Y{ͼJm#\w/rm?{̾0m *(&W{itz8{O?ϱ6M҂qnh46&~XQnS\\kbmdGA74 8bkزp4]>ƈcu+ŀ^{c(+Cʘj,m,;⑟ g_lc' 7~~́jkNI]T GقCO#a|ꢫ+E~ uD`U$9ku9֎y('Nbˮwz%%4 ı==oeni@Ra5 +k:lip8i5n0ttC@7I 7EpdLZil \_MV`t8p8G6zbI"UƎkijKgW3ޞ>7qCXsBX Fwr̥V *¡VɆo y]G]u4" J $)%PAPZ8ZE 82GaŤAzloYEܴ}$HԼ8hrq8r%ehҥEos,w tq0MfR_}2~\ Ӱ仧{uyo L7<IE_B8I:ĩvz0nn.m_ƉSOg_Sq%maGӊMt_x9Rڻ0MsH$qx fӣ?g(+fd -Ş &Fʅʩ)Xk[ٔN1W$R}q_JNz.$$a`v,b>$I 0Mx 8ntrx01q:Q~ rz18#*&' vG"$! =a0d0dQLG\^^]3$hjgEyރ:Չrxټsŀ;H1M3iMqP6&NCʉyBdp1 md۵CGd$OXD~^PoTf=Vw};!'I#[#)-ٝ ,猓!hG*TM@L#:1=e!GL>7 `HH5P(k2.q",o>]kN*BWWNt]=L:2"M 9B$!_(b;fg2 CaJ\BRYϦr4-K!˛aB(Cme[]ғi {PKPߴZ uEnBGr{ͼUSPL eElUVey 881qt&N'F ,;Aďϓ/c>;[`/v do}ZGo3(g5^])B^vIJs;P}N(/fpbK1A >ETOH;.,;+ W+}8r"wگᡬ`D ,aX ?F\+ε^%\E]a%,P뾌ƑSF76 ]eX\>NYQV4iN#7Ml*ATƍK+LY u>TS2zXw<ga7YGhn1qKI _rx6;:n>^xup೩]fdIhP~ ly6j>LSgݶ4 ,_B !*@:%ᦴp$P8sF ;y뭷QEOa.F YFRP3fϞ=\. 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!!vݫzp8qV"kItOqB{O%Ƴ}!0;pm* D~ 2W)Lqw*j'˛5 ɘrZ{{SN9s9+Vm%KSw J S_it;368z\䩭JU8@ZH4ԣNwNxpar㒻A}>YUFWܛ0x3>@}m.AVnL mDa@-@ 8Vn蘦Uej*VZŜ9s:#ԱJ GlI8|T=J0O8 ]!dUkځϓKT$?2r|E޿Ѯtgy-uek&H+oᆤקN_"ũsgׯ_;/GCpY8rsI4]ECsj;}25kXf ~:]v7tSvS) pjbkc_xЉDCtٔF1-nhl_*#ϴewIhIHlSŎ>kk_N?G?J_EI0 ![+s~W]uj(bę4rx>~`AR2|jS駭4"sk.wjG.s?ϳ>H1ٳP(GYׯ^ﶶrcPaXxYE7p?s=o9gHXSÒ%K3gs@l5,Npx3uj%,Hzv4 '_O?{ޚ25N}5ow=iӦ^^](uko~ƙ4UWWt:x<~F SLA#zx.f Ã$Ȓ{eL^}7}mg*@uU @]||"eEox^|+ ٳ{g+ /2&3mkEq`H|;},-7ݻ{6z-N:$&Ni<#lbۭ\p!o~N"p#K2,EO̞|#'%x1xve0~WRZ0;چmөwY;k FQ=yQd' d.;f kAPLrSFI&Q^^N4%;;χ x.s^Z$8wR(PAӣ& y%  |.y^4McoАy:m۶e@\@F fMP\8Дk!}B J7gXvm c7mNjs'?kqqo.Xw^AX I3ob."2pñn7nHgOsUߢ&杏u4f@ UQdh(ڱc_WS~N?I#LD 6,i+/7;+\f#7}"ى8}`Sm_{B,_ËJ GRϓCT%{mڡ]vh"\.nEQ$Od'b#h?o@?+_CQ']BdY;x~;3\y汅e]nVQ<)5Dq0{9jkk;S1g f1$$$dŎ$4Jë cO[5#Osu1{lnFnx!&t8uuZJT>Cn/Fioojkk_LfO3BI|VNa4чwxYltCC%>}3<݇y>q=PMyf,Neܪ2o޼!;Jp\{p(-Gd[v治/|tO9E!T-+y 7v!npvܹpЋ/U"D'a82Dݳ߱LS^/J휞 b7beszq:\x}jcXvml ,u.޳3eXa+(y@Fɛa+;TCKO A.;>I.7/ /{+G{a[r&,`zi0|7k[`lfՆXE6|NNH$Hp><1$mlM˗/Oi{'7YN~^1Z_c*=amy |83Pf|>aS aI|_yg-g[&>sɳÝHBfo'}*H@\|IJe{i>3M|ܬCKz~%}x!S#[yg.yʟu0euMV;9k?G8*ўjOs~$}V۰P$HW#sG>S=O"./Y'fO>ΏWeɣ{hQCFN7% `:5Ogڸ,پ<$!ry3NȸpULǵk还8*ŢGl,*X<,)ȫ4\Οq9*]>hّ GŚ'6cZ:I9f[P]6Ο^8u,:$! w@h9Q(yȊ) )F/֎&V~ͼbTJ uDS148;g'R+q8C!‘j'j' ƓQ$O.?z( '>lo>yח>gql!yd (̵b'FJg֎U֩1̴}ڶjP?,oOqxq4#-'ueS\PE^V 829 KQ0 *xjЎhGF.c]BIp}GphN:dIƯԯ:֐Q}2z4t]cՆgԘYjۏם,Bgd|vZBH~[#:|"&Wkvl8%gWnӋSq#K >qbܹ0wnU g"jL@^r{~8.O{فiB0u2sM's™gXD .Zpa`dbVQ/>Iċ£ZM|+I BX1L!$N8tX6ȝg~&K2 K ]-C3c_s8|xx`!K2)Y4hno:?%WVrv6θj:aiHBBd$n[rki`TC㋀/촵vbC.?pUWdYR8bq?r$ YdCYA?OBg(RԌH)qg2t<9CmP5 _XJE{mNPH4Ey r|asP __X]0!OuU cGq ?]-y(IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L[!!k !UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@( jjURR/*UU V֪?ZZ/QQTZ_j__jMj#Z֪*#PUQR*UEJjjjBZ'j ZjEi֢ZEP/j֡_jB $I$@I $H $I$@I $WWf#?Oꪪc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???aa$??k3@P?d?d?d??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8PNG  IHDRcIDATx{|gfr "W*-JEAnxAyZȣ>XkZSGkS/h-(P\$Qc$s93;l Λגٙs|{9#Gh6#bL^k^ 5k/7n\WGv! ^z)˗/ddeevZO=k׮m~afb ]PYf5oxxM7qu!.k̳Ayc;U3bйGYE1~*esEB}{27EW?ϞW??ˋߤGYSr/_޺ 7G}Kr]ww^^ ;#oХSzPYռ~kRFHhA¼<yΝ:srra˖-q;''^zAјTUU瓷nKqqq누v-^{ {QMӨF،5>Jj|t)snnbVgC/;>:vzKJiaY+1iϙ3k&5F }$=/SӨ.c˭P(~qײk. -.1M=oZ= Fv'?3l2 uE4No)ӽky|=k~:o1"z|,iq_RXIIv5nOEU Ues8"quCwBs~ON0j97ndټ8PuD^A.PTվ ,`(트Rjt]Z}9"]O %{LaΜyGOʋ/X`飰KJ* U3mҞxJ+(r,È^j.`+((q;a;T[o1sL/_NNNhUh^A.U%~%ե*H' oT7yi?U {UhNΝ;yj-+DIp^I2XLb}դ$w=Ioh}` sM;ԛ+%9]R`$9;7ds,[0 2&oJx !1pn6l ;;mR㫤5 jts,kc"?}~,iU=|VUo۶e˖vN/}l2CnpW| KlٰDs-+|A>x w8?BpS/Q{-B؏8P͛7pBf.[V8 .T|Amxs4;84[la*j}S9h {W۶mQt̩@ţdM^d?q+V;GeϞ=1 C˼O!ȳ7qFJ^z%ә4iRԘWhFo85{DV/Lvv6k֬a+[UVIcmmVV}BG)9l>)qϿLTxYv-<Z _D% 7&u߄R&Qοwv:ӟؽ{77oo޽{fV\ <&qMCck;7駟橧BS]wGu2tOX@J`ɗZ} nk;l۷swQ3< TI'MƐ!C;w.gyٿ?G󑕕@IcڄPJ1aGyzdMhHiq0‰D8`7[ˣֶӧO׿5>,\rI~1d>= H ~bl0nHeّҙ;c1d6mĉ'O^ իYn]i ̈́Pz{zFud~p7IY/ζ6$jw92N%jzefs;ټy37p_}o&#GtQc뮢BHN:H'ax{wd &2n"q˖"3z?H)[>| Ƙ5k_=}!111crJuƬY-KxKC' Bw{?-夞g$&$`$ ihBhafIi1tL)&.A4#k֬Au,ˢy摙IQQ9TJJ4MܛJ+y#/_EpRϰcBE*l~ފrRt "e:A^x[S_tEQ)(i^݀( ';5ÝS(UƻmQYM/^q+;ӔŦ] }bM0qt6"R2⟺N (VKHi0[IF[,8C*Td ?bCOL+d-;v-FO7`9[*Pw[>|>O}=03z6]on8w*FoKDe6*~4T St l2 <@طM⏫=,htsoBp#׊(v~OL+jWbG)$?@ߌZvm+j੄n fMZkN[;`;DDSYS[-d?ԖW49V42k Zz5jFR8Y z;%wgZ_y$hU!W0…vӂm꠶隱:="^;8*ү[UnTэJRE>gUF}v&~g3zTr?وЄ6/8Mp[)R }_]=Fߌa`G E.7g2 s$~_j_U5WlP]EٹJb~HW4y-@|!^霚&_䰁cmV̰ ozuƶkٹۡk()]I0`%Pk'eV 0fT{}"Ji)4rڑB bHi6l$ߴ'{[t[42 N)327OCt=d Zq)-@?#`M `&^HL ]3Љ|tm-􌮝z OiE˄S'9~"_R\1Ѿ[@ tp{Zp!^ELDTa/1@ ~,i:v )%;$eIMwihRY/ً] '8겤EPU%ad):+I`dk.UGxe" 79ugDj64؞C'gK=@mo-1h,WLX}F}Нx`w8}P ا)8hݗCa4MGC4k;)Jз͖ 9s3„۔5+%e`;;CH? \ƺot*uk(ObB I )*P`M[㹏;\6JZXnܶi9n$~GjfYmNR:N1„H%mH¶ Wy<&GL@%$1l2B֏oМ?g}5%-1x' 3}~GDR+V+n 7!Jt?)oFlds32TI?o[Tm(HeWb&uFr\6z8fqZ]s<#H' rT]D`n}u;:O#5dt#CO`lͭpn[D;v5w#Fi7|[zm^_)op7^tJ"Dn|vj%#s?j:!wx(41$ _ sOp`ۨmᡎ 9+td.KZKNP );wo`Ols'* NoO֒&h!mW*ԣ!{gYJ(}JwCV<ȝUϧLOp-RK$jvf/yS&վr;8,SrW|ezRIj|n_2Jy?Qq-L:4d!]ϑc I)T*HIDRb';g]O@ T* [*'U.='_8u6e"&Fg ,~~OFTT%ԉN$&$#IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0LN!!k !( jjAjU_Pj jUBKG(Z֡ZZ$T(TRQDjUkUVUO///Z_O/j /j#EFQj#_֡_UBP/ZH $I$@I $H $I$@I?Wf#c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???tl$??}@5@@d6?"?"?"??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9pQPNG  IHDRc IDATxԝw|3;[ԫ%7ɖ{ 8bJ !tK¥B`0؀{U-Yz^f;;ڕVj-ūٙ>|S>FeQ3f+QPX4|?c@0MC E7\fc+x&O?/no+N̓p\h ᤳrz@$o#˝KvV>BuWtʨXDmÞ#B_p0 KbaL^G1[%/}_f)*i:6ڻ\S󠪪_ @ FQPp8\#RN nO**&ga/('1MS0MLJ)8WՑE41=bk>SH:haLQŀm_ #89&f?~i(jyKA7t@( mlt#&5 .H!cA:RNNV0ai!(I  UTP5 Ii$;A(s. 3^ǝaꘆŔ @%&_CӢ|?yoKci),+4M9iEH|%Lʊ&֝<(2@k957a @/YU  lY:B1ሏP$@8ĥYXGJ:P P|7Dn,w._3x>c[}MaX gldƏξ)FU}t\"GG1vj;Ÿ(8Ծq" W<_q^|agb/bT(߷<X6*  kD>y8x=VN0dgҺtuaFEG sMeѷ E2YP`Q*'.DTUCEU: SI?z85-8BH{+%mwlE7⪏}U~Uv~=G6q9@]{ ^NWsv uIĵª5I=4Rj~ ݌qu`f{CH)L0]qLP6q1QYUu tca#1 a@XO)?KB- _>-Ƅ*^+S˔[݈ zigWhh9<@{}Vc//^q}tZ Gc!"ByL Aaڄ,y..KZt=iOJ40 K "dq`قYqZn}i>(4&=wPkP}bgZ9 \}՛J?? ?Nmf<XC}BcB01 M\qsD5ayP5TŁFh0?ÇvsXz? fe_-u_(wΈUXRزlklzy^b# H^6հͿ,{k>@cQ˜4MCӜ#Tml5"L7M\8a1Rdݳ.d"'0#ytq~e ( '-!jGwӣL?7w~?ܤBܔĩ"0Qq=(¦&yyy<ߟOnDC?hj l)UcsQL@sP =5z5[ߡRxƏ:hl=bkw<}/B AB=4Vp:O$CO0.&{IKPPQ?2eJqjo:`_* SG5M / ȩP-!G q55):n1Lap4aؙ2#[`?7;1S ;>M5|XeSkYSζ'OF.%H/"#y4L]!LUq SꭏR\R1`<=ӅƖ#'qOFa/'[kZ13:9ΐ gJœ` ^Db,-H,w.1#*?SSw4x_%}fi ߊ~w {9x3c g/y=`%1rjq97{5M_*O2ȑ#iVfhib`_)LE8ț`gP/9vЉ;np++ϺxMM1'=/ZlٟrLp΂ˈ1t=BȀPU6|fc0XhKVʌ3ؼ5u-3-=V/$Gq~;5'vqּKX:BZ O0쵗{>| -KfC-\݈FW/y>1C1=F̈=7xܺ?k?v_ЭgLDT+(iűƽ2|pM"^2X6e+01 ڋu͛rgGw7!g$++´ x MX,;=CYruFi1;Q"CmTEe HG;,:oqTImfʏGng}߰ƙ ÈQ@R~!Sl)q\F\BFT]1]*{(\pMZ0#bqL7u>qxg3&/F݌#854-G<<ɷSP/9Yzy.tKP Hòa@"!0 ]z ~5b#u)hmk>C ݏS'w70(ׂ]B|!ebwZ;n)vfNm的"$ xr `W8c(/BAn)GЍn0 ݈c'P8T+up%1mtlv<8p[>2UqNy >!vCmE)F;")?¼gtzbÉ9J0I]A<Tƒ;QӰۮ8UēɄYyWeœ,{_$ۺcfTAuîSl&MNLQbz+*'.DA;H4Hq8mcgp~װ4Exz[* 71 Ƒ]OX^0=V ngwΐKٞ|.J>ܼ>mGiHGu{[.9@D9v3^4W%?f(#4YY(/dV ' ]̢5]YL,BQ&z|mÞU;6'۪|aCaq*mK*HH]$/Ҕc4즩PWߟ5޼L:O]A9ViTVV"Stx&ò)`|t|bz(R]?2V (+8PU_=4w'[ʼr~'G@nokZQx@ZGB,u>0eQbQ)@`@ED`]r_;s`fLZB#G?Úwܷ$ӧO=op_/A EuElI@I +إ.fm&/ Cr٪!H[h8sn;t6QZ0c{9rHjEae?R^]j#+iMnZ: U'G{_b7ݿL(5O/7$,fkhjC޳/{ûh?vmzBEp:=h'k_FLf3 fW֣DbA{kfH@, @~N)EIcwy[ l.駇v-''g`%ǩN="k|@9[nza)Cshۖtӯ'0Fˈ~ҍ_x@Lj!ΘbGcZ/'}K%1=aITӰk {kμSS{e .=x^;?֯ 8e¾ʹ4y :b]إ5zEףv|2Y6>=m&7bʋ'O1ڪD!{n\`jM 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M3?Ƴ>͛8I&'?`~Ϊ$u}Qؾv쐯tQ/ۏ-ەz!`*ⴑz)$Ep_;1=9uu[4kPvhfOK4~A:S<{6, t%l7Nd 8fL?/17I(@Ӝ[pǑtZ1؀V =vKşw<^vi+~⚨q2ѶHL:=sK^1tL0FB4~t&UQ1vNj`p] uu>zcXq&7!FoyehL(nEeMsEޓiXV"ƕNk1 Ct3-SS}K pq-u=|;Sz3ݽ-hRWTdC}`fv#9TH wtdNݛ =6"tz{d[o P7(gd@Q$m)YxSA%)I+OG/Es1.6הt`ÙpyX7 :,q0G&clhkO`񕡈W“O> Ho^v-DABa?[}ȳ5 y_)STؒVAf:k+E:{;TӖ̏1M83-6˕)|c_/' d2tLmUB;_ _xq1ʋ' B(!9Y_I#Jmja)z|D7I\FN(f1E }V=W| NyTv 1ũk력8@WK=Rno+'ѵg}*(+)0w$'zIۄ4V~kǷKVBP=m,Rۈ_WOZ8]t4EP*eC6QD(t%ThEGasaڽұyna k@(U%}kEK,q{9)@qkD_!Jڼ>l^gC:݊yy7~u XҾ:Yyc,Rv4zzl{j\H#_ Pj4 oӞlOy\nzLWO+Mm5qK+]QQ=J^x[X֯__)iD7救7qBZPl&'V]lbw.~_0ef>4 ]B0xEzz 8a2c5f !LPTK 6/.@G0% Z1bR.<r)/%7/^ LehGɤdUvXf "B_xnv~apZK؅Uk{tS_Tե/qPw~T.hGֺFsޗBd.4ȜxZ7_-Ro^ze^(fvx\9x9d{'S@;3 @Xa/.gB)Z*eW~c(C^N*#:hnnbqå߅FҢ3Sښi$pjn.&Y\aʹvsrDY(fL:,ON͍ۙMNV>w..!{S{֭[?ݸqXIq1q9d{YXGJ>eƎO-8 #'>U;CtݒCnh+VH-<_Mr E8^M{IjNkx\#~lơjYQUwwR^^N{{;ָo|61Cԝ}6|?%FpG)7 G\a+DV>ȿK͂`}#ȬBi&֤M7 \ݝwppiI@ !% i:AS{ Lx.-/K4$XēΦ o %ͻgIĜӴ448P.Y. fҸY:N\Ms<iꖟG4ٲL7!DJ gycǎկ^8h݈O`}Ћ5kְuV/_ڜ?e X!wbD'NF>r .)ڳ6IN[LjĂV`֜nYlDsjIcg|5JϩBs899{C. 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kЍ̲VԼ|wxou#fM~į;P@飫Z|,`=e:G59x-dտṯN>4D߽˒"-Y*Jsc-<ⓑЍ_{+ 4C&IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0Lk!!k >?!gUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP(  jjAjU_Pj USR?֤kAV# /TkU֨5j*U"*EO/PPԚFIU_Z/j֫Zj___ jT_/H)B ZTZUEP/j֡_jB $I$@I $H $I$@I $WW WWf#ßUT c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???$??I?9@Q9?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10BPNG  IHDRc IDATxwՕӓsBB99c&.kX^^lc60c,A yF͌&vG3Ÿ>C[ݧν$$@Q@$=K9aۛ=S5I . 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WVLtUt:$0ekcu4s5; IDAT裏rwt'hIBsHHA]g۵:!vٹÅk s;6Z|_ϼy2e [laŊx2眎I$ôv9ZӰYDvX`}+lr.y?9ƛoft]%`C p\SBk|'w;^ee%>̿F," f0,Q4{} .Jb3 XB=ÓI9<sV fk%*M%_߻J|_x=xom咴ud:GAII &ڼ~_O n;a7&+ēa3%X1 Њ%IBeR8,yWs _9.;ٔdIt4echnn桇.c׮]<E9 ԤCVv{f[ AE-0_plVL4R8Э, j$IbW~@Q̩RlDy:1 ?L0_~>ƞ 6v|Tֵ!/xAP%_@Hjժ~ pr02pIǼ6 ;߆! s&( U81YQW^y;2yL4*x#u0fXh͗\Iel۶ /f|>}goΙ(0={vQjf,?zbX<>+^x*bI3pjmW0SVL3+cݠ9Ccmy\xʭ\t׸`-q5fUK;p7z:?|pg.K5k8<!z>/CnVv|yy9?@5Lk>O[q5^0gS7j/~駟PqiN$ٔV[nnhmk֬aaN:$6o?̲e8I&b1N" G Xr%O>$L~QCYSUsSSnucYKT xk63_Vn ̩"Doz ǥz^aɩO!A醖[{TV6kad+ȊK"[|Iu M8uM[}\+l۶.rJvnO? `-ԩS;w.SN%JQYYɗL82׏ww+qzÅkJ:4Q(-Q)TSZRg{8'.8ΈIW[oB}v[IeYETu<(($SiTY3)"k-j9V\{96nثo;n˚d gjƏ믽ɫx ]Xl K.v&,XiFuu5/R__SAttAA.>6dI&N$̄L1Ȓ$q/Oz5eiaB'k+yV]PQB!xK]9vdS.L9z.B^/;@$~S s Zk.2j\O?[n;֌3u7;sRnCq7x)D'DUMqN @$Ya墋~a+'D,ݕ-` S#jf(`$PB<5M4EiɋZ+?\rIV)(ۯoEqx2soc9GwXO>j0@x:Dht&Q0EdƏ3(^dF{EYI0G,)>ykd$J 6| Crsi]Z/2|~NN3'-ZwbډB !/`E.I⺓@u'::;wy|/8'ajuC8f3'-vG p[qSW+&R&PRko/& <OQ4.OWR8(nꆊ%CH֔~ܳ)dOCg΄؅k;CQAi~Y2{ŒAn/_yەwwW\qv/fM~d,Vxr?bfM^$dgL\m4lťx6q>Q )̻T8~ډ\tmȲ\ qJyચK簥jISлl ?-pf̙1*=?x|d2I" o]w?bTjlgy7a% Itl=pr5e\smL3OG}u3g }6=HUx9;2ӽݕٟᘉTD*cųOE|*b ̥uuu?-5L8x eOxgg8@C>kn`/gEfLZ$@d Fek@$jkE(Jgc/tg5Wb& Hì?X>gkhaRj;+X>lp ߔ+ hkk+k-:v(!ITYM{3Fc@# a0q,kYAޖ纝l H*Ô@!tC#$$X/ q/9qCh|`UB'E[9ԸR$=מe?Oz`3m(@vAs{lEbQeۼp-oe+f6$nL2mH1p.N7 KGs‹ -=غm3Z#AFMlp F5B"4^"II;k6;T h&:BYAbD=5e))PzeEEڐ$ɡQ`N[q~_A8ֆ,+$t`5o5"U:섾`c I݀$I vyM!/~ZM35E&$&;X4{ fL$dg/9yPpLs[ 3M 3A‰4N?ȨiB"NT&A2#O !9nhJ*' wpqmF[jMcK-i57l~E\3WT#m͝]Z6W qlJ| ё5ۇIfZn)4=M]n~1ilV*0z箺pM;^5|^U.vsѬtW[!NmO(mN} ?mr$ISAڃDD$QjAkZVTVsڊOt$j80gδ膆@|8$^2όh.T-nB#@}Ӟ~{e?0P4FOít\^4]etc<Ϝi'rGl)Kz ]d-fT.=>K\ohj=H$$@gv+nQĽ`XwwOah RK $@[.奦^:vE) eqa}raT5Lne攅6䉬KRq縩2.Jp[&PL! kf:T*ɡ]>0`uRwf,@5ұ5+r |Xy<N:@Mrm8|w 0I8*JW0\eR j7&G;Ie2q %'v C3K[ݢ2mN860"He<-b="& .'LeB_[`&5X*ǚUO#z(x2D* t0u|w#0#Eq[ړ69^Űьʟ ˆٗT=#2g]z0zd:J8F,!ŀh +۷Vt ΃]1p !xva$$HgYaih$28-[( ѶZ k{\$XX"˕5\qwI /4lS{h{mƛ/ۛׯQqNnɦijг1!4-iT|7TWǥ x"!Lټ=!QRqT5qs2J8U؆ӷau,%#[ j7v4n-hO*04GPdu])R<"~t&@83@{?n8ҙGM7?RsO .9~-Uug%~ FMks9nt*x'vy}Nwn@abqk}hJ[θg֔HLU8TMSQ:V\EU8+B-;f$ʏu=7<&}u9~:Z:[= QZRI*W^{DR􆙓#[*5xsMVfMYJFKο箺vq].@HH$$S1t76o ^ cddO|a+olz\{ϓJ! c%Hii@}^.mh?j-Vi 跒,%y3*IDAT;8L &^Kg.qg|.-ItR a:t=cv_IӰ=eQg Pr6;^9ۂ ւwvz).d\,C(6vD:\okQZϲDy"@hS{d~fu! [wghEV_ _Y1$k9?Ԏ\4lE xP?EQr[ݫ#)˜r)/ ;k6QSﶾtѿ"`ke(CN,V :Tq&!ICnYk<ɋq<|eIXy\{|o}D"Bŭ8:U[r=i,m<2欓G^böd@w^#8PGuѼN.=Z'𝢟OiJ,*m-eTba`1i|$I쓿`ösy! [{e M'.ZϹ_ jL*0%JK 9qSX$S_M0 ʲس)gOs bܳNJ/G`W Nڥ_ w [_p y5#IIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0L`!!k ?!?( jjAjU_Pj USjUBKG(Z֡ZZ֤֨5MjG֡UVZkUTBBB_UZB֡PB֨?)EJQR*UGRTQS_jUP/ ֡I$@I $H $I$@I $OWW Wf#'?UAUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???=5$??@!9@@/?` A?` A?` A??@@@x@x@ ???333333?333333???#~j????333333? 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O޽{9pEyz_"hj$Mc 1FxXU bj|gM- +>J +vK{8ް^˲̭W=0Į]Xf +WLSgFΦș}SM7#!QS9ˡj UtH:t=,Sl)/4m~1Ng'%D,wx?5bZ#hlKOpL& DV%U&&Q%L8_/4*NeɴܴK|ahJ2To̐4NM2&`,ʯb:lpIPyjJ$" iO>P8@tEqV/\Q6,O|Bb܉ș8c؅Fސ5 fmj(L*8rH4NZH4hiӋ#FX4s=^Q%˙EET=Hɱz!F?o ?LK$bO3g2tf!ƥU%!!cCdd84V;Z oPrY6 3#J;jD`錾AVl` +f[jq^J9:n$J l6(Ro"$OuI4f&þo37& Zx,,[gC0)HfydfBh48`؋ʡp2#nz0wj,u dC%dIbݒkpỮ}pC\xyԪycј/T5qdƓ9쎫6|WԨoj?NT(6ij;N[Y#X^fDZ$Y\z rˑu%d<0ʮ,vB4Zp =\L[G['mx ΄FFC\x:?l0bhI(`VWֽ̙:ozQ(qbXxQ^<aD9nT;r=Bˈe#B.G4N]|HLS dIL$xqoFlҟXzl˼bw @yk OyqhFS1n2qnzkDhhF0EPrwY ^(' fnBm$[ʚ_M'b$ z^B8暊9Avytrށ6 4!T|j[ΜD!+t!~ !4+^g4‘ h%62jCdd=NܹkdOEi$I]Z !KI6sL@h <g!8lδV6^{vo~ ^-!iAs'W5e-BlNf0Θ9j;:Ɂ,̞g߰ sMHHBEWNLv]$q[-'K$Lx΄Cv'Bά{`Пxi8cUO̔V#3bu×h%ϙa##CSi9%a= GC=46mKqk7 fM[Pɝ9t5s֯`h PZX ĸP2>FHDw\二.Yc9>f9tU0f!I(2#Y9+eEp8Ȳ͊g 汯_@/}p Mohh@^`7ljBA(ⷈ҅^OӉ/h #4lBh1"U8nv%RE#VzF~G#(/XICebʛu]lr:%%%]tt[8$F# aI_,m)x{z!T5u0J f YTqV?*.aƔiO"+f.Iid\).J)3gjkc$YQ돒f Q%<4|Yr)̫tc۰;d} 3hiՉ:i>e1s4 Mt7[ֻg#㴟jxֆ8F&5D3EJ7nìh4D+['1cʲx$~ytniu9M[(}hПDΆҔ"LhQdhB(oWF̺;F|!xċ,`Z1)4v#!ћl@|\'Ԕ';ȢZ.0XݶKe㊛ +A$I/NhӁߢ?.Wv)X"L*G "g>hѲx`d9f)Hikw^9Y}B^$8hnVCDNvvIDAT0[2vE` =+ԝ!J4]XM>ym(M/dۄ)H̾as$ڕ ;v)Z{G &,vʤ7sgm}Aj./4*uh(Sɾes/G4wח[iAki614m ɜ3C2D}A"^h!*QCpP&\ܯ]|0^ͷ"6zZ֌)˰6ںp[<^3͠?U>_m8dmbW({΢j h(i@X02"Uڱ^"/7|8b~(&U!HU4O|x F0% (4W2@w3=-H#KI'Ba^9֮1vm_~`_Ә,虠[51fnܹQ5I~dw;QBDՈ5JME­W=H[w$K.<.Sl`Ĕ.:FН58ri tRU"!j_F$Z; 2pL;b✗z@dM5V),5U1R)mshl?f[)V7;KA 4# Dd$z?Nz`(:s#mlsHٖC4Fl!! !KuwraߜBkSUZ #-B_dF=\MZ%,}Ed !1v 'E6IB2"%vv_%.83?8` P{YC.DK팑']#I6ف&NTIR1  {b0'<GfL颭3ښGl:W--0c[` sY&n3ܲ+xE}r~ţD3B.ln%@hpg' -*CHVVKUY~뺏잟&=>pnl,2ax裿ݚi3Fass9-Nr;s,oT`ra4χj0 MCrhp4D(f v#{z\ҡX9ѰSo >/89-ίԷ*_>  {=zԪL7f{($b8o³u\[Ȓ̭W=7n/W',>;O&Z;uNz9teZrO_ܙ!WX`G 4H _`vfZiʋ>sg>0B8teͺtlW>of3Qա"ߤ? 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/oa`&_>}3d{ pHI%iqU_0|7 e``3>gbbfUz##Y&F& >{Cq/9 M<#2#IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0La!!k >!??(  jjAjU_Pj USR?T֤kAV# /TkU֨5jZjjZZ֩5TQZUZkUUS ֡*SUZB֡PBO(JZU֨5jZU_/ R?/ZH $I$@I $H $I$@I?W Wf#c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???ii$??`0@G5@@5?Gͳ?Gͳ?Gͳ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12%PNG  IHDRc IDATxwx?SNU%ZM CMlB1 %fÅ%enK&@$KR)q,7IV;3HG:NdKy}- nR:'p/zW/ P)<ڏ {(H{+>Oo!$RZH)@J#PPѸ6lj:?r0{(`{uraS&B){?i |>1x(L!^d|iU6~oW%P7pW,9Ғ8!`q{CXSʭcP؀ΠC #3aF.iGJfVÈ",k-ĔP@J<7a1USi<#2G&0Fh,R8+Q}D܈bI {|}njKGEE%Bttdލ#!oEQQs @܈!,+FEY ˸jZ?|6ʤ=*/ 7m%xlA2)*`y]zz8pdoV5 $H:†`|2cÌ14c<e M_N9~wJ)i5(b’'EQ (,Êcɱ'@,In7D}CGauI)pn4mic !LV4TiU[ ln,jGز7"aOh"XoV&m!'A3VTH/Xȶ.z B^L)sRrJ);JwJzhEyi5h#l9C?H~\{=TbZN>:z}# i:jJ=]yɑg"BXH)snF WހWQlÈIL #D5*4&ɓO~|=Xi\.>QhK,|kmmͩg?u;pfU> 7RFn`#0Rcꫜ}UUwxk} b͏[/$y((ɨ_ӦM˼WENYx=>"GD#kIRe26%L z+3RǢ{ftk ̮,`Zp&I]si`Zgy&կ3FӾ(:6څZ8O' tͅE,ˠ(,w.US* N&mHK$VkVt7!%|[{Nc\9": ؾi„3g555\@0RNj+u"ᮂ O MsX;;oBGu!S4 g.S|P^:؍#F$)H!.=J|L1ё>yhNQfg5ξ5mvfY1#W"J5?CieݶKT@l=WMKxΨl6&s/wNХ .ֆ9TNAY$#TW4$sVLNKBeUDŽ0?~ovr{UUZcWX0Gh,L0͵+:&y,b= G#ʆ:ϯ{c2 lK EGn[Ѐ>Nq.u>e9-5@57) 3åQTN+-4if$:5kַ2z oГOrlE|-s!NXgEwoװOi뮻ʘ8}#寿zx'B ܍aFNm{ߡ7Ɂ#O0Kz'Gwp 6=;C#q2$ ,;KZ;je3 #+&z"|'CR\7No-l,9+dh5yNAAUd\)%on~XSLyi5TdV\In-Y|E*"EJUTU*(?po[R͜9S^y歗UoAdLMIso<bw(]G?,{}V>3cl8QyG Oܸqc^xa̟m<'ٷ柉<rw_$D"A-Zģ>ʻ;@ `;uuuZ^{:+>=Oify50 .1k_vdKKKV~yEkWн/Sc;plM~k# Ȱ޽{j/_-__ݱ-<&0˒EKͰ[Sn6lm/3g7POg,>xh4 6|A~\ a2ysMxje:ٽwӛ\xyv>x`N4;ئgϯQKj/Ş=;tX"dL 7ӎB룼ܱ=eϾL"%8q5mI {͛732>hJx#2xY}0>Ґw]c1yxfY0X @I`޽pIo&7tF5K˻@:7]q| Ęgzw7LV(d4kp޿n~=> 9iwG&6<¥0:s+2P s΁GolܸKpݺu{yR(Sg溓ì%rVW=(g5-{1e< ><_c?}>pе /yW1q#ƼI4Ʋd, ZYdvm3(]}c>Tats没i`.8h,//JD" tO=ݭl"9Ìs|˧םL𠕚. S(?E##cٷ >n?{ В䙧{O@2Lm_tqWgte{t,8ڸm(;G>xB7"v%Rh<'pغm={}'DX0k%~)yjtEgrrhnrXlBxN[\s =h.9٫_L~O1^|Qy{IJ󦟚 FQJSC\EvYi;ر =٫B:j?R*av0XSJ͓s=ب#=+18azPbqKja#Tb)BعG=)mn{..lTVסBXNDK؅ k4Qp7~o9'=t7N"ue3HJ ҹ:O:-Ys Ki.@b ӎhDכNB"'ɓ .¬S[aƒSvr{H)C;S5Mo#'ɓ^xᅼ% $iƩeYaBU{JSfQC휤 %џI$ui`&F0L tj@Mgagt 4#K0P=ўI/t)j*~W'#ہmzT;pqaEwx$`Zq #6I5>;AwY6+l[ADrC(ҋN$`TB@{e R+/вg~ $`P`'i{h,;qIDAT$ydS+B` `~d?=ؾ uuQM3礴mҀoUu(k۲ !-h,w}.tUz:PRXC'vKJpټGRy*jMZutd*L(U޵3N:#ھx8["JGi)5XOûn^FŷYRk~ts KZ< Ji /~M$ony&m yx_P?uV r:h?"YS6OJ47IN̟ 2ye)e?ZEq"TXĥyXj=Re@N2%PQ^RA rx,MՑH;D gwVR^~+59^i)v{Zx@z,w:ڌZA}]#PEֽw~KiIR @`>H:š`Zu)%JK)Zr q3F}LG-xITEkR݊%L; nm0C,nmH)E\"@r*-Nз`M&yHM(OL޳bi6m $ax}󓔗Nen)H)icy}oӶ=g2^ù7 3Km qSX,K'ڴbgo_/}Q`X8t.7򛗿o[ino)Rzx#*+JkLA(Fx4},sc &v?YdfbV4HۦH)Q%XkRm-CIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0LZ!!k ?!( jjAjU_Pj jUBKG(Z֡ZZ֤֨5MjG֡UVZkUTBBB_UZB֡PBJTQ֗j*5TQ B֪jHR|T*O B_$@I $H $I$@I $H $WWf# ?c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???sd\s$??I @p-A@ B? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13{/PNG  IHDRc IDATxyTչ{zhnEDAAD%&*jO⍉ 1o ō"+Ȳ,)Ȳk]΍Dt[y2rj?ѪJ\t=0SifK R=(3.FUܸ ##K2,; o$?Kf1 S﷯ȩ .[p.mLd7t qLDMšcPeEQQT7mOm/, I2jїvX}(L^\63[3@ ټ뵔ov 8]HEVHJOU)L ɖtS 3,"(M%$ե(*׭ktCC7t$wYKu'ORTE8f͍o~{wCJ7.N2QOK p;0-U9;GYnGeTEEUUe?F ]-Izwlָ%wUc!VI`p:K.EIbIF%<"A]Q.Ǝ'rQUUkv0>YA~se5SD0Fj~i&u&*nd)y!^ g|\4gu p^$I!uڷ,+ ]amO?D -TcލI`:pKn&5{;K|籟~Mc9n-}TdYB44M# iN ׍]%?O#γ\|bFUM9%!0MAϹͻ\wKGe" 1VZilbס{zp:gkpmcy,vyq HMYd!R6/4W{%dR= ,i7US+$4FZ [ Eq~Ĺpƕx~~Pe+ɬYu$Iv/Vr6[ =ԉ?rZDTc 4GS̚C8>l=s)͕8{T[)d$222B$IƥꧤpB,υdK)u̝@B#iK"g,2I;}rqEg*L>! q޴F,I 3|~gK@-9HbYd$'agT1Q½r1[ dRj{[qEg"I S0t Cs-;yE$O I aE U</nWܸd#c/(*BDAjd_ǰGS[ BH 6Nĉӣ7i)M/)%ހߟy罷))ȿkyŜ3BKZ&w-_a$VZ}糦.tGn0Ȩ$4CCcZD9^}i@O8ڎiȒLUE-_\;yΟu)>LJZ79.+/-$B6.m*O F3`cI5rHW] ~0G: pAV,].7,^$ɹzѝT%[i 6 ΫmJۮnQQ\)Q]wǟ~"nA3b>i8vEsbX::ڷe n 41 `#|獤YY݈aB7*uSͿUnOKq[i怌tu))B0҆y,.ӱ,>X,渒u|oV.;Јڃʹy05#p]SEN3ĥzpn\ǒq,ӌ^)wČGX{d ~g;@>fZ a}wz͛~F$-D[qPLi!yuhP3S6cʢ.`;##!q"2Ͼ/)&S![gAhAdIra) (-# ayAH+˱ګl5jO5DgԥHZXrk g\i,7ɒBUU\.>!7WU? k+@A'y{k1g2ڂ,#U;?aK]xXO'rf](nĈi4jbxa()OUQ-;'\c[V<:+qFLX$דȷy(pm&:B+{'Apv_&a COz ':} =n$2x@`YYG;MPsڔ⾐v\<:d${CMG%qr[ b"oSǟG?5 /{|ekW|Uuh,J,eG$7k 9%dfWLan)+~}nz„8kkKEchZVvU) i#3$4=j+v1;qrTnō?# 8@?.V_N}M)KNf~i:3_V|6뮼h,'i<ǒSBKV⛑iI rgXӚ#n`4,c#-7}%1-LLi`}!! ڎPc ΰ|[a̘zE2{gڴ`&y{ƝKa^i犧 DeX.b1vI2(- g,Bo?0)\|´^GGeؤM"Mξ=kš+Ig_lJ?k=>fRLOK Ζݯʊk,ɣE =R'`7 Smߞ}`@}'oe\d{ťn`È jct嘘ĴEb ʚv4$NEJ ` =; ӎbZD9u wϱ~]"- PUw`@@K{E0MYFC[M" n=H,bb z%wSWZkil=&3DU\hzEջhK48Vwɛ᪝L;f\ߔ+{6yYchnm~q9pEPqư$<.V CCd?~oljbh++ߗiDbAZhlbˮij=Rŀs9Wvy0AL8|,xPXNAN *1t&%-@/ﶎZB &iȒJD b$uCs[A/K݈"Lڂ4TQXΎ例`@FBǏCCv@Wa֢>ڹ.TEu+碩6E&HMijA74&LO_ wʊBihw>}=ü)Kν@>BtCәh0hn%'s >gsںH92TK[5)Ο,5kEPe|Yg{>>]p3[G7I8N}s%ld@:a.nW4kgt>P2J&AK[-}Y?0XT"?g,1=fY)tLS' ZZy\pJ>w.Bv6FO)n>ƍbG Z:kI5M6FξLi##U^aaס\z.'Ć78qݦW}4ݫ?F`e脥L olYIBĴih?dCJ4M+9p҄:r0 =TD.V~jgXq'Yw4uLa"*`ލNKqQˤp¯xudmaVK]S5 Gزk`FF0&""if?ξÒcld8)LΚ8@F.d ɍ;KVړP L;sVfsk-Mm5l1p"i+×'E$>G9(wd3 G:G; ALjf[I2!)Lx!_bNZ͝rBz<.Y~Um H&n["OIl C=̎=> o~a;IW&]eɍ' 0-}Yvj It6{*()211paϞ=G?_"W_}u'vY٤q'J}9dmdx:]$4"iP n"Ó&htY`r1yFO&hJK/CLR=\xKK/_͡K/D(駟f/ðIxHzBv|@~Tl$vC6{/8oٲe\|vmݻ;?>tbTRUqf:jD'  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X@mQ*jPSJ{Gm:P4TY:$r7rKy7(^YcK(y YyU6xuXml1|ż闳}j9e.Ճa4W|KX=0OIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0LO!!k ??!( jjT_UBժ+֤kAV# /TkU֨5jZjjZZ֩5TQZUZkUUS ֡*JB֡PB֨?/TkU֨5jZ*֡_jB $I$@I $H $I$@I $W#c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  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'/CXجNn /Wv/Yƞۏ<ѫ甆J1nug;at~j|ZArѵ8ɄB>dp憡0.Z f.Da.7Ln_ǀHZ`G03fuCFs:xټnzjPSG >A@)l5({Ƕ~^\5\=^xZqM_z}C^AoĽBƍzx0AB n[n7xzeU{9iaPՏdX6JC\1xZ[ /Ñ#hU`Q,iQYVz.G viHu ?`SdgC);r4nʽzo3n;|cxj:}9=ج0\!4F2X~OHqeH,v;r;Ϡ iG&e(AN n*_я~Ŀ[_٬n^ųכfYO=ڵZ*)cLjF`fj*B{8[-4Vj )ImGl\,~R ?YJE K:m="i-,An`uA_yTXR\8/yyyTpsO'.64ME6=f7UUwQ@Ca_ӞLVhE?/C沋n'X$=Geĉlܸ1c0g~ | >l(\Xq>;WU:!9$@N[M?qHqe=I8lI<᠎z 8I`olQ݇'|{_B&6 VSDps'=BI6l% f7x`-quWubn! nH=uyd2~tҒ ^Ψ(jW?>l`{_Y`<$''pjRe]x_6<04M% j ,6<58k/g@t4Ռ z `$󦮤`dr3'sCzbtK A1&H >|Cx衇xw8G$-)q޺zMcǎl~OBV)? ܦaFEcϑ9ɺCxnnrhA/ZI 9|CTX@k&8 ΊȾc#`ϼH?F7J_wɿzO l9+%c%dR7$gZXxPp|55OEGFuNq?J|~/|JKeðX:aP0z*I<U~͒q:ih]6 wy+VDM `ޏaOlO8IIV._!IT=͜8gVW[n^jr3o<ƍו!l5uC`Æ CxĘ1C\,. o >$!!8RMYa<޽WsG0 Η3޽f]".^zn'?,u%(w/[vYBFa v]a83w[LGc=u+Ah@a]ر*cǎwlMy +>K߇? NpyX=PC\#7|qΘӸuC+هQ9\~m-C[oRa: 4 6q/ =N8qsdYoYI?Ow-~_ {>xgstLV:m8qIOz%t)?>rg/Ȳ45ugK`; 9D d0X[U,_zqTRgOHzul~7t Jg#XY&{_xEEEE߸I>827`Ң{9n=qKYހs2=q~v>RK?aP(4plڴiL_?xTVVcQ3?GD݀ X/I [ &$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$y?IENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0Lm!!k !UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@( jjAjU_PRժ+֤kAV# /TkU֨5jZjjZZ֩5TQZUZkUUR*U$R?BHR"*TTPj֩?P_/P(KG(Z֡UW BPjI $H $I$@I $H $I$WWfWpW#I'c~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???^^$??`R1@&1?@b4? s? s? s??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15PNG  IHDRcIDATxyt\}?,۲-l86x]/R&$!%4KMM$ipNpڴIz9- 8l 1o`+7Yeٖ4?}hiF3#},{wfww(k QD(H<'`"DL$Q0x" &ODD(H<'`"DL$Q0x" &ODD(P BMŕ.R9H7W\9yBB` mR|ɿ)[rGDTh} 19/{; k(gS㡟NxtqUxI H:8n2:ܲ%P$} KXS>`J&q I>c<J"񔀕 Ңe@. Y,q^nov߹>OEQksF᛾>jvUISdp.)]7ɴs<ήӜjo-3Y"K:BXؖ14˓Inoq^NS'ΦB;q;acvD ϼ_EQSHy!rJJYK trkCHME*{cc l+AMb1;N[_,Z8 A ,PưKJ"R*k%DUU2ʼnV-ִcθb!MOB-H<䖥 !G"0'{u4QI"utG +>cG7\qt6ۊai$Jt΄Tt%8N(ǎ3\y%B[ [Ny 9in/I(ǎS Ku'GzwSI~Q %@f+_"HIE`7V8P29nIX ^ϯ.;y-om?m7ێ߽kǍS =.it ;P1+X,>V]u+0!r]~*eI1}ך~)ϙ9ےPi`*LI[3Rv+|ǶUKmzpZ̽ xxcOJH3DJˊVӦ0tb"X6A-ϟc17Jt-Y ).Q* nuyn-OpAkk݃aQګ"b!,IkBm%'`֬YE*Iypeja[8]]_KgG)ņ [*j=W,ul1l+?9TxN]"7L/|;p\cyeܺS<g;\?Y<~[qsQJYz5D۶bľEΰэhm9`YӖ4v*tt@)p^߰=^u.^ȑ#ijjj~zV9_h7LZ,~$ԴVax݂Y1,#[oqi!++HƯ6+ d<cXS1Μ9þ}8JruvRM̿F=>ު9R$VQcpOBthKZ|$=F@PuTxȿ22|2J$&A[rWT䔌Jw| Gp2$^~fy^L䍝T))þj Jx{ Ό+aWt*']U*~q:kk,{p} O~0XQTOG἖t -b?M$>u, K3LLӚZf#܅^Ecځ<FBB{z~n!% ~-XxAtkHYuJJiJg_b RȐBgH K(BXؖeˑo-|p<: vl,7)m" C̜~FԌes9sM,.m3e*b|3MtV?10u{%jԀ& ;&Fbq?fr֟CZٳgOM,O ,]uecʕ̟?x5ڶpLW]ӲXNsUW1sLG?Q9;D>OJIf`["9Bww7Dعs'X^5uνa'^ŋzj^XW_}/ce'_[{dAOnR~u|_s?OW¢EذaG.KMR$Üp;L [la޼ytx'8u?8'N`˖-.nyYdd؉wwoͺڵk={67ogye(А5<' { ݻ,~C<رcǎOfJKykd>Z}_2w\^{5֯_̙3ڇ/6T˷jkqZD"ѣGy衇xWhjjp!.E$Å ؽ{7<)۞}Y&OƟη=x;Bi<ؼy3ϸ={rsB_!O~oW^0nۃ[畊H:tueݾeΝ;j:@007x}v3n[j.\`g} C$>[~VXɓ'ٸq#YfJXz!OZZZxQ=lrJv܉8~ѶtUGIXmmm;v+VƯ,^81x^ȓ%-E(vڅM6ml˿]_X0Esܴټg%,mhpH<غu+Ǐ穧ʼCoax7..U[K/Si |fR%(5W"G`K[~*gTH< !لKB+s %u4yy[!`ׁ0o>Xuߡgי5J"WT>s?'OVU$MhJ /SJTQ.oF>Q#75gz~/u(0fšҟk?ůi}뗱m,}! _3 ,̰ϝ7|քXy&xua! 2)w5/׋lk^W8͹_wY5a@h=BT/QU4Ѣ~!6/{G~uHӟ_ᚏqv,CcBLoNw~qBL;X,VGԁ.XNj~Mo4m Jy<+ R(/}@J (XK 4ac l+$G&J{I:=HG~*N< ښA'ͧ1 KtŔߑzGEMJFB8ǂ'(Qe3Ikue"#@.IӃГA4nR1v@U̙,~Uey͸DX2VNj4CǴ%xiVV`BM{BP1e,Zbvw~u ^O4zn.v^Յ >K!Su' AB_Y K RZa:vmq},alCA½.,&>aY~N 5yqz}kӛ܅Vhd=?7MfmUcyf]D-X X 1+9csm=Gw0y ]թ/"yǰb1;mDZL@pOHJAuKŐ.ɐhN=ɋy[z&yG`1{'Ucy<-'N4qtRnz,0#A5ea [;ᖮcvizA2uS_>;\\'ؕ4"]PΡ++#Pg3e]6n*WyJ\\_#8ٖe[(ӓ-)#Ry?:8R /"IO0]TaqNO볯\%,ֿWg)j#RT5pܩ~0fr̷e&Ex$x>ɈGI+\sB`~#Myt>5LEs/5gUbyHδIsMԥhcq;+\[^n?{,qITUGr+s4OX,~FXWUXS(S.HV[7}ILjKPRh3blTkbKP(^Z1:anic׾[7)pFs{Kh6)V(>rUK/wތaE fTcIIENDB`move=1000;blend=1000;3N0LB1!!!( j/_jZV"Z!ZC[Z_T5!QEZIP jZB?UkUVUO_Q_UZEEEj/jZ_T5!QZE֢I$@I $H $I$@I $H '$,pB f*5UUUDI$ %UPhB$DI%UUUUTIUUURI""I$TI$T%URI$HI$""%UUU$J$""$J"$I$HJUUTHI UUUUUU$IUUB$DI%UU$$II$UUTI$RDDD$I$DDI$II%UUUUUUUPj"$! $$*DI$I"""*JI$Oc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES13N0LO!!k !9ꪪ( jjAjU_Pj jUBKG(Z֡ZZ֤֨5MjG֡UVZkUTBBB_UZB֡PB֨?T('֗j*5TQ B֪jZ֡/@I $H $I$@I $H $IW#9ꪪc~binding site for residue so4 a 416ac2 1vbinding site for residue so4 a 420ac6PT1~binding site for residue so4 a 421ac7# 1vbinding site for residue so4 a 422ac8031met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES))1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RESxx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESff1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 416bc1 1vbinding site for residue so4 b 418bc31vbinding site for residue so4 b 419bc4&(1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES**1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES--1met->mse selenomethionine MOD_RESgg1met->mse selenomethionine MOD_RES11DFO 33\7 J@)EEEUR*U*JJ"UHT )("TTUU"JJER$(QQQUT))8  fDUUEUWTEDUDUTDDUTDDUUU_UUTDDUUTDDUUEQ@EUUUQUU_UUDTEWDEWDDEU@_DEUWQUUQWUUDDEUUDDE_U_DPUDQUUUUUUU_QUQUQUPWUUDDUUDDUUUQUUQWUWQDDEQEUUUDDGTI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@*?333333?333333?333333???????@???0K;?fflserine hydroxymethyltransferase; chain: a, b; synonym: serine methylase, shmt; ec: 2.1.2.1; engineered: yes3N0L3n0l P 21 21 21Bj;dBأTB$???ab??? AAHHHHHHHHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW!aa h            fB fffffffBfff ff fffff ffffffff fpfff , ffffffffBff fffffffffBf ffffffffffffff ffffffffff fffffffff fffff fffffff f ffffffffffffff ffffBfffffffff9:bb S             pp ffffffff$fff ff ffffBff ffffffff fpfff, , ffffffffff fffffffffBff ffffffffffffff ffffffffff ffffffffBff fffff ffffpff f ffffffffffffff ffffffffffffffaaso4saaso42saaso43sos] [delaaso44sfrom triaaso45saaso46saaso47saaso48sbbso4sbbso42s/"/#bbso43sbbso44sbbso45sczbbso46sNV_zbbso47sawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193bwb194bwb195bwb196bwb197bwb198bwb199bwb200bwb201bwb202bwb203bwb204bwb205bwb206bwb207bwb208bwb209bwb210bwb211bwb212bwb213bwb214bwb215bwb216bwb217bwb218bwb219bwb220bwb221bwb222bwb223bwb224bwb225bwb226bwb227bwb228bwb229bwb230bwb231bwb232bwb233bwb234bwb235 _asn  _ala    Hmse   Hser  Hleu# !" $ Hglu $#%',$&%$(')(*+))- Hmse%-,.04-/.-1021325 Hphe .5468?576598:;9<9=:>;><=@ _asp6@?ACG@BA@DCEFDDH Hlys AHGIKPHJIHLKMLNMONR  Hglu IQRPSUPSV_QRTSQWRXUYVZW[]X\^YZYZ`  HileS`_acg`ba`decfcdh  Hphe ahgikrhjihlkmnlolpmqnqops  Haspisrtvzsutswvxyww{  Hleut{z|~{}|{~ Hthr| Hasn Hlys  Hglu  Hleu Hglu  Harg  Hgln  Hcys  Hglu  _gly Eleu Eglu  _mse _ile _ala  _ser   _glu              _asn ! _phe  ")! #"$%#&#'$(%(&'*" _thr *)+-0*,+*./--1# _leu+1024813215467559$ Hpro29>8:<?9;:9=<>8=@% Hglu :@?ACH@BA@DCEDFGEEI& HvalAIHJLOIKJIMNLLP' HmseJPOQSWPRQPTSUTVUX( Hglu QXWY[`XZYX\[]\^_]]a) _valYa`bdgacbaefddi* _mse bhigjlgjmthikjhniolpmqnrospqu+ _glyjutvxuwvy, Bser vyxz|~y{zy}|- Gilez~. Gleu/ Gthr0 Gasn1 _lys 2 _tyr 3 _ala 4 _glu 5 Egly6 Etyr 7 _pro8 _gly9 Elys : Earg ; _tyr < _tyr = _gly     > _gly      ? _cys  @ Hglu A Hphe  ")! #"$%#&#'$(%(&'*B Hval *)+-0*,+*./--1C Hasp+1024813215467559D Hglu 298:<A9;:9=<>=?@>>BE Hile:BACEIBDCBFGEHEFJF Hglu CJIKMRJLKJNMONPQOOSG HthrKSRTVYSUTSWXVVZH HleuTZY[]aZ\[Z^]_`^^bI Hala [bacefbdcbgJ HilecgfhjngihgkljmjkoK Hglu honprwoqposrtsuvttxL Harg pxwy{xzyx|{}|~}~M Hcys yN Hlys O Hlys P HleuQ _phe R _asnS _cys T _lys U Ephe V Eala W EasnX _valY _gln Z _pro[ _asn\ _ser ] Hgly     ^ Hser        _ Hgln  ` Hala  a Hasn !#' "! $#%&$$(b Hgln !(')+0(*)(,+-,./--1c Hgly)10241325d Hval25468;57659:88<e Htyr 6<;=?G<>=<@?AB@C@DAEBECDFEHf Hala =HGIKLHJIHMg Hala IMLNPQMONMRh HleuNRQSUYRTSRVUWXVVZi _ileSZY[]aZ\[Z^_]`]^bj _asn[baceibdcbfeghffjk _procjoikmpjlkjnmoinql _glykqprtqsrum _asprutvx|uwvuyxz{yy}n Blys v}|~}~}o Eile~p Eleuq Eglyr Emses _aspt _leu _lys  _mse  _tyr  Bglu  _ser  _cys  Ephe  Etyr  _gly _val _glu           _leu _asp _gly "! # _arg  #"$&-#%$#'&(')(*)+,**. _ile$.-/15.0/.2314126 _asp/6579=6876:9;<::> Htyr 7>=?AI>@?>BACDBEBFCGDGEFHGJ Hglu ?JIKMRJLKJNMONPQOOS Hlys KSRTV[SUTSWVXWYXZY\ HvalT\[]_b\^]\`a__c Harg ]cbdfmcedcgfhgihjikljjo Hglu dnomprmps|noqpntourvswtxzuy{vwvw} Hilep}|~}~} Hala ~ Hlys  Hlys  Hglu  _lys  _pro _lys  Eleu Eile Eval Ecys  _gly _ala  _ser  _ala  _tyr  _ala  _arg     _val        _ile  _asp! " Hphe "!#%,"$#"&%'(&)&*'+(+)*- Hala #-,.01-/.-2 Hlys .2135:243265768798; Hphe 3;:<>E;=<;?>@A?B?C@DADBCF Harg <FEGIPFHGFJIKJLKMLNOMMR Hglu GQRPSUPSV_QRTSQWRXUYVZW[]X\^YZYZ` HileS`_acg`ba`decfcdh Hala ahgiklhjihm Haspimlnptmonmqprsqqu Hglu nutvx}uwvuyxzy{|zz~ Hilev~}~~ _gly _ala  Etyr  Eleu Ephe  Eala  Easp _ile _ala  _his  _ile Hala  Hgly Hleu Hval Hval Gala  _gly _glu     _his         _pro  _ser ! " _pro"'!#%("$#"&%'!&) _phe #)(*,3)+*)-,./-0-1.2/2014 _pro*49357:465487938; _tyr 5;:<>F;=<;?>@A?B?C@DADBCEDG _ala <GFHJKGIHGL _his HLKMOULNMLPOQRPSPTQTRSV EvalMVUWY\VXWVZ[YY] EvalW]\^`c]_^]ab``d Eser ^dcegidfedhgj Eser ejikmojlkjnmp Ethrkpoqsvprqptussw _thrqwvxz}wyxw{|zz~ _his x~}~~ _lys  _thr _leu _arg  _gly _pro _arg  _gly Egly Eile Eile Emse Ethr _asn _asp Hglu  Hglu    Hleu          Hala   Hlys   Hlys  !#( "! $#%$&%'&) Hile!)(*,0)+*)-.,/,-1 Hasn*1024813215467559 Hser 298:<>9;:9=<? Iala :?>@BC?A@?D Iile@DCEGKDFEDHIGJGHL Iphe ELKMOVLNMLPOQRPSPTQURUSTW IproMW\VXZ]WYXW[Z\V[^ IglyX^]_a^`_b Iile_baceibdcbfgehefj _gln cjikmrjlkjnmonpqoos _glyksrtvsutw _glytwvxzwyx{ _prox{z|~{}|{~z _leu| Hmse Hhis  Hval Hile Hala  Hala   Hlys   Hala   Hval  Hgly  Hphe  Hlys  Hphe  Hasn _leu _ser  Hasp    Hglu         Htrp  !  " Hlys "!#%*"$#"&%'&(')(+ Hval#+*,.1+-,+/0..2 Htyr ,2135=24326578696:7;8;9:<;> Hala 3>=?AB>@?>C Hlys ?CBDFKCEDCGFHGIHJIL Hgln DLKMOTLNMLPOQPRSQQU HvalMUTVX[UWVUYZXX\ Harg V\[]_f\^]\`_a`bacbdeccg Hthr]gfhjmgihgkljjn Hasnhnmoqunponrqstrrv  Hala ovuwyzvxwv{! Hgln w{z|~{}|{~" Hval|# Hleu$ Hala % Hasn& Hval' Hleu( Hmse) Hasp* _arg + _lys , _phe - Elys . Eleu/ Gval0 Gser    1 Gasp               2 _gly  3 _thr             4 _asp                 5 _asn     $     ! " # ! ! %6 _his   % $ & ( . % ' & % ) ( * + ) , ) - * - + , /7 Eleu & / . 0 2 6 / 1 0 / 3 2 4 5 3 3 78 Eval 0 7 6 8 : = 7 9 8 7 ; < : : >9 Eleu 8 > = ? A E > @ ? > B A C D B B F: Emse ? F E G I M F H G F J I K J L K N; Eser G N M O Q S N P O N R Q T< _phe  O T S U W ^ T V U T X W Y Z X [ X \ Y ] Z ] [ \ _= _leu U _ ^ ` b f _ a ` _ c b d e c c g> _asp ` g f h j n g i h g k j l m k k o? _arg  h o n p r y o q p o s r t s u t v u w x v v z@ _glu  p z y { } z | { z ~ }  ~   A _phe  { B _ser C Hgly D Hlys  E Hasp F Hala G Hasp H Hleu I Hala J Hleu K Hgly L Hasn M Gala N _gly O Eile P Ethr Q _ala R Easn S Elys        T _asn          U _thr           V _val               W _pro      !         "X _gly  " ! # % " $ # &Y _glu  # & % ' ) . & ( ' & * ) + * , - + + /Z _ile ' / . 0 2 6 / 1 0 / 3 4 2 5 2 3 7[ _arg  0 7 6 8 : A 7 9 8 7 ; : < ; = < > = ? @ > > B\ _ser 8 B A C E G B D C B F E H] _pro C H M G I K N H J I H L K M G L O^ _phe  I O N P R Y O Q P O S R T U S V S W T X U X V W Z_ _ile P Z Y [ ] a Z \ [ Z ^ _ ] ` ] ^ b` _thr [ b a c e h b d c b f g e e ia _ser c i h j l n i k j i m l ob Egly j o n p r o q p sc Eleu p s r t v z s u t s w v x y w w {d Earg  t { z | ~ { } | {  ~  e Eleu | f Egly g _thr h Hpro i Hala j Hleu k Hthr l Hala m Harg  n _gly o _phe  p _lys  q Hglu  r Hlys  s Hglu  t Hmse u Hglu             v Hile       w Hval              x Hser             y Hasn     $     ! " # ! ! %z Htyr   % $ & ( 0 % ' & % ) ( * + ) , ) - * . + . , - / . 1{ Hile & 1 0 2 4 8 1 3 2 1 5 6 4 7 4 5 9| Hala 2 9 8 : < = 9 ; : 9 >} Hasp : > = ? A E > @ ? > B A C D B B F~ Hile ? 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