^Y3.6-1h/data/swissprot/ 3LWZ.pdbdupa 1UQR.pdb([html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.65 Angstrom Resolution Crystal Structure Of Type Ii 3- Dehydroquinate Dehydratase (Aroq) From Yersinia Pestis[/h3] [p]G.Minasov, S.H.Light, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3LWZ" target="blank"]3LWZ[/a] [small](deposited on 24-FEB-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1UQR.pdb3LWZ a_3LWZB1  1UQR3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 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ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ/   UUUUUUUUUUUUUUUUUUUUUUUUT@UUUQUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU*j*?"5֭jJHR"QRG֨?*U(?U֫UiH꺪֢G֨?EGZZkR?֨?ETkOjOjփO[ZUV_]TETGOoT(UFZխU_ZkR:UTEDDkTEQQ5'TZ! ( WfWWW #UUUUUUUUUUUUUUUUUUUUUUUUTUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUP~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???}}$??t<@@I;@A@F@?6=?6=?6=??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2&PNG  IHDRc IDATxyTՙw}YfEZPqEE5dԁ8L37!&LLwLF1ƉA'QD\1 FٕޫVݺ[jP|=Ty90(2;jƎl-?G6tq9<8n7 5{U_I8XS y'O(gЙ~| 0{'9ِ|-YχUpTTqDcmh:h!pI$+Wsv$֙H-EDRN/ýdQly:"" z 5nhhZXO9i!GIWΉC*"KNʂՔ+8V(x浟Rly,0^wI,膎nha(lIIjnJ 7D8X[۟P}#Vx::D1f2o5z($P,;S4IMETIͼZM7oa:cL مCv" 2mh9v8*6@@" ~Dג膆㴺9|w@ EhjR!Ɖ'",zUJ MIr ( !9nYr0}Elm` KV"JY?n[Li95yjDA0t8j2N<w9( aݟa5pF D[JTicswUguaVYyx>w``цaK׵a4X(NBU6\QR_gQ{C\!RœP2Fo:/O׼fvH$P,9G= .D$0GX0~Y]]y&xl@. ˔s'5X1.Պb ư[PC JQ Z;=aE8d'dX"$J8`&EQb|QpXvOJjRr971Vkh-'S:*D6"VJ5pPIjIjo&O-AD@wt;=| oQhj=bQԤ%4Z2ZڏU#1 #`ohmP?KK1qL*) UAz`ѥY!w?ȒPD|{@pv6Gkd$}L? 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'BbL3AZ0 -Xx! 7R$N<&BIk'xxxxxxxxxxxxCJ}ΜVY,UxAl mh7^ொk+IB<%sk*]3-$%~ -OK [H$ M4,+`ÆlxϏ#6ݑ$G׶I3g v۹̛wr !K3& ҹslI<&3۸ bR tڑyΕ"k\XB nIENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ3   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUDUUUUUj*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT("HEJTQZj*5UIRkRJ$THmj꺨֟TQ֫TjZ֤u]UkQQ֩?j#֢ZkUTjO HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHO(WWUWfW W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUU3UUT*$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???$??z@@+@*@?????@@@x@x@ ???333333?333333???#~j????333333? 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s7}2evహZ WGcdI ?#M)1d% OgPA)x̬";" 1aBIPG|;!?ɓ'sWG{…w(]=7{ng.Y|n}/ԞkGv"F'5iry?:Va߾#ZZZ}hx|7a/;G4aTf4 m.(FUq"@lW4 ~Ʈ]ex<`羜;v}שּׁw\#t,ghCG;Z*AХs{w4*jw RA0܅ߠp$V0c0u͇+< ā WXunQ8:=LW H2OG+$x/t@+#GnshZfAyyyFzBCK? u;< .$Y+QҤ~y^ ,f .~f鄣#Z[; /J8 ]=;CCVMW':pzyɧ$i`?0hS2f!%#XizڝXXe%4H2_'Ek=k֬,%w.&ƵvmО#t/؈{x@׌%q?[_,8_&T}jԧ)|ut% q<4{M'@kǫn緰w)ϙ|6g/: P|xUhmk@:z|fub:nfEt h7;ɺ@aⓏ9vHqfީg`s :3c¢C5<Z2 {_16Tju N$BA`,W>[wL^ ϟÞ 'x;gKL`Cmd,yabw'9T(̔СsUD@]a4`P44!]D #)43[j|‘hf Ă~V`|,?"8)zdQ׹K+xih%Rv͘1!=EM9&I ~b쯙w`A| ]v`:`κA$U!d9`d[*Ĩhwe?vJ@6.l{KǕ(F&zi ^<ٲ`1qS{zL(_Qsq]­3|9 ]D02Z+{MJCM,W`论r?b6Edg xͨB4FU,FNs-p4*4yq%-?ټNm!_yIWoŇO=թN~N $gSW$hP4]CQl.܎dXW07W1qTյ_.EZ|kafb _M;_BDJ6#^#E@ȓB:=bd J\0d}3<6#eIDVOO1sz?\~SoNAmI_}ͧό#3U.]#r J"i*n}sjuģt8*n71g6k9:$B4SŶkhrQU&Ou'FQc̛z!K҂e*Pla+p!F2k+tp?TEϽ+uƾq|9o0 H4߄ mF&1Ǯu3_ 0cyhe]F3/3Ԧo[$\8E ў7|O$ەϫkc6u\Bqeu1$sJP8]R_הrQ^L}"Un4 ;蔩 hVo=[+𔕔cd9sX 4./ij05v4/#Ex{HW:h,%#(-䙕O[ cdP^Eyua:ZDF/'^\r {/ƍm.f <`*4x"Ɇ#QUxCfɭFxOQ\0+kA޽2zȶ$m4!!0D5"`v*<b>tUz2=X:Jr E,M&kvZpbr%Te%diiȞ(1t]C2o󘀎2/goFsQANh{{1IsQVlkD7,qV=ԣ>ʆ  !I'8hdAb4 >;'7!I( 5a%鹙;"`Ԏ瀞iaȄ"~*k3kW3}˹9ut4UMR@ A54 'Je͇))Ƙ=L6yC I& afL"ɸd Evq`JnERRJV#Gaau!v,dAQ㝶Fϧ[E]Bu} (_FvV!rj3SD679B1- /E]Kr#"xK_ۙ f luD8'  {DDc!t]tXq2|)fFBb0;\(IbabJU*f$- ;NWTT|nghAU:uiϤ¾ꉁƌ`tC&0x86XAcݼF2A崬 lMu2EC5Vo*kwvرY,Vo$3l:EyeZ[bM׺Lce![=Ȳ7ح.$ɂbГhAj2FcA1$IfuvrIu{ͱZzVӨq "QPfuQV2.lQͪZE=8!4 Q`8xzB}KPS\cM7h ضD0KK2cpavYTPF4`,4V)+'lwSR0ڭ h`kva +HmS2 irG E| ז$Dvf]ĴqG[ f5zK: ' FGCd\l Ş4}@PO4Pw?a7 c*9Y̚t&,:~$Q" t&dsxq%/Ќ?[Ӟ'HO8⑧µML&7LEQ^$h4N{6yej۞ql6Ux rj*tSB;hTSglW~FLu (%]- ֏DџˑC}aܕC;3 - QUHJrI76~ VN$xy rM1+ d p9q`]1e%fvi4 &]6 dnsulOmX-vDb&XXDJ4S[4EUk:pfovSrغW__ߤ6=9'D,ٌ("Ne]f$P3-Y2c8|L:>hy|+M|((p ;ہd"7DB5]*VcG+Ҏp9r%+vՁ(J=v{"vb|CL[֯z {.9Qp EcI1i̜y/=v54q`YYv~˻˹'3ՅFn> ׇwIDAT]0pȟrm=boa.`.QZʾkoX$Eq]?fʔu9 e0 GNR^OFDj4h$βņ/Bek5w+@=P<]S. /|n4$l%t5SqG&\$ F%~͏BdG~6‚H>W ^I]6 `HwL %l4^kIÓ?.DDxA(kp4(ϡQ4Map(M4%B$l)c$ɂن.yUS5b0ހB3,?[kh:#]eIENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ2   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUU?j*?"5֭jZQRG֨?*U[jUT֪5WUZTZGփTQMjGG֨?ZiI_BAIkT꺪֫iZEjH֫ZJEJU%UEJ]UDTDFITQZRJ(WWUW WfW#UUUUUUUUUUUUUUUUUUUUUUUUUU*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUIUUUUUUUUUY~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???xp$??p-?@N*@µ3@?s?s?s??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5#JPNG  IHDRc IDATxܽwTevYzJQE|bMhL FM${D#bE J]Xvާ{qgfwݙeAܹ3wy[I@@B@e4-̩G '_|z#0vl ϯܞT%3t `5}WFz.$#K2%ǓEaQXT5 Y)@D2!HOϟS[ÇLfj驨V:s Je9Ջ$MF=,"8e[ij& %^]AB p} х"#V\gla ! <>jas%uB>PYT[JtCl4~%0#wKŎ D74tRCc9?zϷ$KȲ Hzs_ƿVMX rᢟvjSoJxC& ZijfSy{0EHDa$)em_ a+=YR0 -ccvpTtrVd)6UQh $}^jȧ+(nDؼC Ǫ݊bgtt*u.t h~$V$‘ v[:l7 [8$ʫwt97͞(b%әG3oqyã@`04VlNF1y\tc'k!8l#ϨBGއ0AU}x6 !x!D7M0gڙ4k0δgp$ bM([QI} w(?sTٕd(+&7s<\iHzX- uj_:FtB q49a16ГmF銪bK WW}Iy՗9hbQU"hn! 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D]Xr6Xof?gg?oBx"B$jIʋz̆ >?=wI$i&@#Bn4]e,I/ioo/stll|0D2iw}/=#!i~)p-8<@D!d& :{׽L9ELvq:84 Θp-݅.*OĒAIQ=} W}A#wQ_cSd.;.$I0XZFJT;JYERM)Vn[URjH@x"j^w <"~*5'-(txHBQ5\()DUm+o?1jO"qi FF37ܴo{ʰZMW%BZʞd(U8xh~UnyqNɮ__e?yd Ӕאl9ৼM(O40ȥCo|r4"ZLw?ᦼ-W*]OCwJ[/; Ӡ'q &Zr.D,{o65bÆw^$1~{Þ{ ϵ5.W;L4Px0Gj:J< < O H7ouGKߍnDcAbHns2ʲs*䉩u(WrxٴIQkZpph"%7ᤫ,cjB2CŲJyf$Ԙh!%fm,˂]¥7dC$ˤ1k%;#]aQ]>ڊ)Lw2?Px @yn_5<"hh)4 EȲYצKzOȮjKj7/p2Ze"bD*Cc=#]w~ iC wbS& i`P$Pȩ‡sbW uZn>=6j|)  iH=vs4Gޠ7ԁn|SWq+>t  ip'h7ivtC9qiXz:pF|FUvĔ g|35_LL4C}$4|*IENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ/   UUUUUUUUUUUUUUUUUUTUUUUTDQQUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTJ_HjZR*SZ*֢R?T([*OU֫UiH꺪֢G֨?EGZZkR?֨?ETkOjOjփO[ZUV_]TETGOoT(UFZխU_ZkR:UTEDDkTEQQ5'h?$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$'( W WfWW#UUUUUUUUUUUUUUUUUUT* TUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUV~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???$??RXA@ t5@?y?y?y??@@@x@x@ ???333333?333333???#~j????333333? 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SZ,nn;v7!2Iaۥ~zd3B^_D‰~:̰ȡ?zۭ.\VWo-BYYY +Ls19f>]EDe$IvZR:j}ғO,ʫ_a;P Ӊ: 6OXv$( Eq#b Sqq1=XyC$ѧ%]g)Y4皤9l7}d7 y[W0:w;8n,r4;]Kh;y}75[fpY9 Ī?pʞ`w麴?k"JF3g^Fˋ$I_6hon{cz禛nb|sKzG?MMM_F Jav#Ikq(.S?!INN,YqZϒ`VfOe陶Wr˅_&zն㏣:o&Ol>a濉^\E@/~{H*]dtC;e9I'@&dHRlW$e<0VC 3MjdŅ,(ǓCq1N󲞠_EQ@>n-eӞ׻WU3ʽp4@~N 0 9.C>OaٶƩn8İAHL7Ws7]~_oȨo:Js@h,Kq3gEQB?u4Q(7EJZKZ/އν66^mG_aqRgU-ƍ) D!dYfu6U+R3dH$ F њluN/!o2+|]x5iaxs)$uz"*+3ozϏa3i P7H4L Ic`PߑTwHjm aZBb'9#ҧ``zH# 7S^aJ|r}a7w)P}O'ǜK 'I1D-q-vLY^dʔv~r+ hnE`QFjpdάӷp"nc$l T哟Sϓˌ d-cd$ST0~3ECX4AFۇ斺AՕS Ah"U 5i Яp0C5{M`&G]6seqOFh,ӳD 4œ He$ԡWݚӫs\4U#FPP{v XOSK XPMT B`f 4]CSSֱgNɔ)S{V Y)+)nF)᧊Ct~)/oa1.YѬ6˩:+)Wcwz*B$aFaha҅yzP~ ؕz[ $k@YB-uf/]G`p ;Do$ct<_!$*q-FSKM7Acp,H(Ҍq<(Ǜ")!RTS1{#TTv~'ITDIrC4е.P4܊hWh Th 7Z*޾ɒE=[dډ;hP]CEe9G((,td`{{QՙHCBٮ;uJG\zR5`Vt!k!nBx;0Peªp ZBM-m(\XD9cI6Cstۀ}}Dz_oZ5.?kx= Ăs$!Q\ɀ <>% nم?XGS8elv=] G]MY.jsfm:B(ڥvm4p`Q2j1||Ǣgegp8H}h)˙ʥ4++wq|+h 5qpՏ8H. 4 ;IK)Z;tIh=X@B`Vv_E]Si 5mh8m PT-)?ʬ}L{}'}{n{膎HH5kEFc(hޥ&Μy9q5FKP4@LqbjPOE~Vl(`=}IHd4aߩ?X]2ᜤ{?Ol֌IENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ1   UUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUj*?R*U*HU*UiH֭j*?QDj#Wh?U֫UiH꺪֢G֨?EGZZkR?֨?ETkOjOjփO[ZUV_]TETGOoT(UFZխU_ZkR:UTEDDkTEQQ5'h?$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$'(WW WWfW#UUUUUUUUUUUUUUUUUUUUUU3Q" UUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???@8$??MB@O"@@^6@?2?2?2??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8DPNG  IHDRc IDATxyU{}&3d&L!,!H@ˢ^D+WܟQdM[ @Lfߗޫ}g ~tթS~9y$@o W="ZhzP8q_ IƒbEddYiO;4ma`[xFK`K0jbY?xtz[F%@YV@n KK?%.G2rTxLJw|Ci/FYc-z~mkQHxy(ww= G2y,@DSٺN[p HR,vCC::;l'D.;s BGy{yFaA?B"ʡ=m>BFjs.|WoC74s{/I(bAX0 o^ap( }H E0`v&oZЃEk`r,Zr3&(6*w7پMD  Q)/fGe$$S sY*gC1J[DC1 OiѼQQs|*PV 9>itt5rjFRrYƴ'Eg5s21sN0 0p:<IH=nIgefW>+0 h!nhVQ@ +ν3[*:;]vڸ1KpڤtMS ~? w|Zk߼G[p]|`aXvdqn85~^ p$?E(164~Dg]%ʑ#<*7BIV)E%˨}'Fa`ügO=I7^슚x- WlԣjaAi|;&DtAT~]껻_0P$@Q,جQ]iDMA:8Դk =8lMaulGs=Sx!j$DD FB6Wu;m2((GŒ7Xu4*0tfwfM"a.? 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ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ3   UUUUUUUUUUUUUUUUUUUUUEUUUUUUEUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUj*?R?W꺪#Zj֪5խEG(QDTUHUR[jUT֪5WUZTZGփTQMjGDTORj#֟ԟ$THmj꺨֟TQ֫TjZ֤u]UEJ]UDTDFITQRZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?(WWfW#UUUUUUUUUUUUUUUUUUUUUAUUUUUUHJUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUJUUUUUUUUUUUUUUUUUUUUUUUUUTUT~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???"$?? ݤ5@)<7@U;@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 90PNG  IHDRc IDATxyUU[2I&! =- !!EP ^ū p41 d$T9?g' 7'UN!~_6v+a,4MCSݠO.@ofpinv[CD 8u;PY ݈` M0dM+?!7]z/RJt#̣Of S ,2kB:{ZPt80"q?zP)%wvC^Z:@Ol~}4Ui %Vɢi/{h8HŁ*Zh8@Da"z"gɂjA\=515]>0) KwÈǚBU4up; @7u Sgv!δoh (h  X=F11 wdHOZ F[<C(qF% '˗C!@HG )*j6PQS};VqH +.Ͼ~/BB+"MuR`aL`, wQwpwZ5lv'~QUn.5!̘W64dI i+žp4Ȃc.d_f*6c JܒSf`̅dgYOnGWSSnFs{=-tYr_\0![7dH5 SH) s3=34ܸ\}BR aӎ߁) 0RnqUowܝWH݌,|yH 0߷Sਬۄ&9FsN6璗SinO}̍Tk1ˡ'ޚ-Y =}UpRJ\q㾔x̙v40U9N4 B*ڱo KoVlrS覎Ksb:(>m*#p$h{-y~7vmzG8вvإq˥qIqnkONSS_ۭ!4^ A,PG^U\<Qp"DGgX4j c:] ;)%x#ڎFXaG]7hlR [ByynF8#Ivy&4zýv! 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ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ2  ? UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ(UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUj*?"5֭jZZTZGփH?ZT_"J"*UEJU_ZkR:E(_j*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?(WW WWfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUT UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???$??D@.@|7A@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13H1PNG  IHDRc IDATxy|T3 ’YDeDD պ[jkgj[u[Q+FAYLf;3&L!s=33{s,s G V̻#p8KGN$EozE.!55p(MSQ'uΟ`weБ>Eiֱe~vH4]AGuyBDABGGuAk 8^p#V@+qP6I4!ґ9m]~U QE[riΘ{%V`A뇦 Gy.>d9 (4{jPY C-$`wu0ƅ8 T֕6YoоhtŷL*ʀkbA•EH6PQ3`0 YMv}7 Y)ºw~%!⓾J_DH#"F4tCD/?2ȳpƏTF@@nA>_͗ݐ- Dsó ItZ4B(ۜT]'LX*je4gO[~(>_#N  "f*jvǦd "O&lzzkh*)dFq(at]#cz s9 oBz˩+fbw8/bu A ]C4TUAJ8oG0dGM>{gδu_#-5Uwۍ2k߸MS:=-`Y>@"FM@@3jv2p8İ7 o\}~yAuZ|Md?|eYUS4+<$Ԇrs9h( Fp0U5"`jo^\q`@ ӯӫc6 |þn»*50If=W=E}AAl;UEV^%BgDF cfi *$t?*I2qÅUT71rNnXHjGTj "+2o=-F&-fLf-q6̴&V[8F]E QH^Zy-iq4Ya9x"#.f'uC-j٫fO=3&+ګF#,ٰ|Y;K J0&m䣙8Q8l.A$Yp{,SİB2]Ð oy.鶢OiEI4uA?p V,f{r"4$4]Eut]nKb ä13krXFK~v!/¡_::dbo2]I}nynEcD|7`b G&ߠ[|[ENFAeUMoFιO4_ $0Hk"s8u@%EnUՕ 4 [((AU|7<:$3f1$=5!"#s3<$E^XYC(CQ$m]GQe|7,){u^H{ܫIq#F<}gM_͌)KQ!n\[֡: 095]CV R 'TK =5ŁӞθQ'ҺAP PTI8qN~gm p:2P9a%5; )Np:ұ[fPQA,0SpMjSsN~~!R2q\}nTQ۸N(ll3}Lm{_4L|U}FFXⰦHjqPvs@'+-Ł@#[cGd BQb%i yRS2Iw᰹h*"r~Ba?US)b԰/m5<]d2mBF ̨a_%&Bzj.v[*{ltemݔG3]1L~2Yo車kag'Ի+jGU})Ghءn.IRD %2WJV̫T%$1niE a%טa^g-7Q-nփN)~>iw $DM>%9 nz'^&"?rPzҕ斺j EQspꩧyEG3ymJ+Jb*JS%zw5XvZMJpӱٰmH}zӖS7ŷtYN)#s' Ow掿/;۝?>~_tAt3ӕE+##驹4!+2r8L(F^[3L=#Ѽq|jMu#Fhwx㏩Xh~l4/&ɂkX"~X+!&լc2>?1ÏcD8$_MGUUV8Qwc2uz;> G" GNCD\LV`0M;_+yVK #HƋ~yW~I]A@L4f͚Վ8뀻K^%// f৕+W;.;9쭥]>!f[vpS rչ= ^#moSR2tO{6vBA6~vxQZQB0쥹6gThB5V-QBG?{ܻ=z4Ne_vlQA1Vtg6YU0aݾ W7j6' (|/A_ZQbDh۟#ηŻOC<ᄈ 4Q\IPsw~w'A b^S s:aǍ;9? }F䪶!}=C61' /ԩxA~r{c8L';=:SfG ECŢj*Qz^a`'fo- % 8ʏOKáqnJ0*W_U ʬ[|_ð)笳սձ&͆)+m-]óo&N m{6hFE&X4ꈼ蚎& fUy?~N51)U$|ٳy7صZ$TUxmٲ.vX4{w5}{xҊ!/uM4+ 77);ޅN~n!#3F'QADABL3;~x壴x,se-^'$T^ӕөS3fFC8evrɅIʐ5~Ni5-(/j>]7R둴( b% )/^;7 ӛ] /wy={2FQ(4O=_u[ǦMvw[+۷/|Uַ[fabD+֤~_ db{Ayw.=?{sk}YɲB44MAVج$io_̞={?~|O%t.2͛i|i40lIB'.<HR4%e*`lA7>~{>#<=_r Ckkk嗍_nݢ9)U6;@י}YxvN6DPz5]w] ̍z$İ=|5*zUo[% UUm\xmq1䉙it^{_eʕr%jGk^zvG*uu x?Ȇo5\+;u3uBGgEcưB:SuuuuӞ* K1%Pʺ=ޛ 4M%a7m0~>;WZQiiitM̛7~̞Qz\briN7\Q$m+ĭ_gݿ5kp?¡>vKj~j#1IfV'凶s 1Hq <VIbw!a9Hz:ݹLLie5kկ[nY;eeWI,_%@?gK9P5;)*(iaK'{ٹL"O# ;X7oW/qe0vZxn+es;ok*Jy8x^$FE Aعo+N^9Qأ5F cEabÆ ܝ-p(--=:}GSJBx&On1CSO0aL,fnD ͕d PuRiL|:[:NP4Y1.}woٙ y|xPҺTPǎ~"OmmhmXz`51*8̘|zhk7.86$]se)륳۬Yp\.-K&쩆WmtyBDBJ `ԖD USiTCXt]dd[ yzi "FZ%B5 ^^.z^[M; q~ mw\,TUPܲvU͐c :` gnYl, qWxX{eQӑ I?'?IyI'dN%\zbHK%ܛɥ9sEEiu6C#1|O:by"(Tz&w.Ҥ3wN6m=%\~pSٲWJ$SYCl2#"p|}x6bX^'0My]Ә`yc;RyykjQZZʳ>PZ={=™Isfx|Tbb;ztfQ]_$q5d0vL![aqD·+Ɛ:Go~:z=7t?8W^id4W`#Ø(k]!;}$("&$QBM(Ax晫я طhJ`hWÕW^=DR=N}CVAp!+!!C0CQC<6㥗^G׵<(z鍊/SO=ŲDز=N4SE ՓFV¨)J("7Kohj.PR LОQzx p`iJbelz^6?|{K1_8QV'&Ɍkkginn>LwE}u]#5%_wbO34TMFu'J\ls.͙MVz>TG&NG:a%_^gRE SU'_{njb߾͓&1gΙ\ve,"jYG\2Fu=B| G.[oiv 驹1DUU$ O!͙M~NQtwשܥ+~ݖ iFH,`Hl`1<WJu[}Ҝ9~d%?BP8`DWttfVَasa:YH)w0PHFKD#p:xlo>qw2m4.0Mb2HnMnMAUa&+(۟d2q~Į#&Ⱕ2`:Gq& VB aH'''-BM4㳝1.]q +!*BVMl  ƕiOG:/LC_\.O+8yLGMfq#ݙfu"f{΃E.d%Ȕ'i*ood 斚R)tC|{=/[2FFWݦ**(FdOjJ)v::8}(RsHsfc:T4IykvH"BFNC5JvlEU"Ri@92SwPSE V SMCs%VZrME9aˎn_j$ф@H1w|l#?g#rs g#V-dFExç0nԉTՕVB{bH( }^& IcN"+-I2S\IE.a/POXR7+Vkߧ4` 7?KrJe6ܕFxڦ j# pyXW"apMt$ jIDDN(,f+D>}hLUI=ej5C̜4 +*H62P x+YQ:2Hud2p|v[ h}  h4q툣Zkvi a9@-LcC/$(m6^~ dX+.\r+Ͻ65Ml쭋fbxv!ޯi:i c^R3_##r! `C4!($"`| N<QE ŁlKP,~ a]p/>Lݷ))' ՑM ˁvi c2l|Z##rSQc6~-STP@d9v@%Ilp_ Dd<H6K dBӴl3Zgj#IfAdߟR&_Wh4S} Qgc0.#ALjc2ϐgql"ik̋XlX͎cKh2Li#?eWN<\4]3"ʱh.tDES5OC!Ba1 gk ~htWʈktN& $Hh>{|"[ʞILt2n;k"&ل{@".:җHh?L q N1# R5 9B>DaV,Wk:BLƫnTM/zޘhʲU8bAxXL'ϓ!YVPCi.A|ƯR9}'y?\衇ԤȲY1:KVqQD|yLȚ۫;D&׾3e x ~$I( ي|^94MO@#iXD՜u4(_#5;yLQF%O\6:"c^:%tȒLb\'w"ߍ[>O>;Ǥ^bbTٱĩHtڙ3zD%jTՋQNdX 3-. 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ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZD   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUAUUUUPU@UEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUj*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oJ*TT(**TTMjDT*TTZR"*RU%II*փO[ZUV_]TETGOoT(UFZխU_ZkR:UTEDDkTEQQ5'h?$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$'(WWUW{WfW W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUIUUUUEIUHD5UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???d\$??C@;1@@D@?ҟ?ҟ?ҟ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15+,PNG  IHDRc IDATxw|߻{t:ɒ,˒\ޅ;66S L KBG !$!$ЌC3ldcM]2?$YNd5e<$Œ ɻcҼ1ZD@yV:'m6 P27ἱ\|KϽKt]SoQ~0B܂!t.:9U i;$5`ؐF]fuFoUjEU} Y5 IG0T~GO,i-aųN[HPO8j1~䜄9nJ=Jmoߏ! js~ aWܻ8zwtB$|zBa?MZ^KHt$X,6_[_?p*n]s/;Ho9/.X'FLK>}.ffq "ÕböcQl(I 'οMW ]a#TBz_%Y<0hPVMY]'Õ"[ _ ̟mp٢Tfїn.>U-f䰻Y)7;3LwSlA[+lAedI!jL=x膆aDF}h Y1cS6,xMa@Vv˼~NG5V,E0yQl*5]*LË?Ԑ>w,IH"+j({T80뼻fZ:yE߾3[]H$XXL M=K@D Z`(m*w~! sOhxws_5Vn;Ls4ϻ8eCM ƢX) ]Cˑ2[A}͍Ģؐ$\u A]],!ˠ=N+tz[QcQ{{+!!qemu]ah=//,OltCe;^QȒ"[}oCh499nmDQdVMjUPi6Oϻ8QU\u2pY. 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A'Mc숙jMi :4 ʋ/v,]bM-O*1[\r2`9ڜ}%%mΝr0 hי ՐP '4kۋ;^N[x5boMS0u(7!tCa|m+L%Gȣ_ó+~N]&]df슻UC} Q~BaHC! ʛokG0aN `{YdyRH ` GAtc83'Ow(h 67+M;>`܈Y"~ŊbaizF7L=hy̸(Ovf> ۛ)c?PGU>62ߨvJ,(_ǟkZ4* * ̂/@0!Pp.eI5OLYz|4jip汉=8u(0hhfWG$  l)>4]eF*dk7y.O/5 QX3.g&Px׽؋V| dfem~NLO6BU^]zYd"!ҹ<Ӌ"& s7pމ7s)w` ,Ol\||6mC^hlfp0l6'N/QC6'txߚFN# ?1&ŋ۞;ܙ/Wxqع]߄$ImO~:30vN/tg<@\x07Vo{{IENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ)   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZ*UUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUj*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDEJ*֨?EG*UGZE(RRR֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB(WWWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUPUUUUUUQ%JUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???C;$??>@@ 23@@^!?``?``?``??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16 1PNG  IHDRc IDATxw`TU?LzC$R#)EADWׂu-Ze]4A:H)w&L&!hxf;<9OnYcE ID Au`-)dYBed |>/^_=~UStMSǀ@^(c~vnyگ)  i ; Yv"  "("z!؎ܞMa:: 7]i`}!NÅ躊ki&핔؏ibVqh}ab4y}- 3 3L0 01MM;lR^ n[ܛVbik:i:Épǿ<r_e:i]cO>M/[ib&;HU~6g(@Vu]C74"tDM@?uDi NӏQ2ˁm=#U/CQTnD(;k vL(U&"h1v#\Kz-gO@Ld_Vwp`+cF74SXr%D2봌ҊMnt CALpMc=v>s¯xk /qȗo;nD lEO3,y9gqz¹n6]IΫ>ԮAtqrNc}nג[E#t[/&'"(3v\uaaΡ]!1UُrL0&h!:ͻ??IǞtDC07"zadptOuNMGӕi0t+jˉqƑ>Q8u|&IbQU? 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CHUϋ^0Rz; ,:tB?EFnJ?w'aF'MD7tTRyѧuGCmXtIk(<0(,9.$ (JZ˖P|a?{aS> GL Cc,)ʚb*hڥM; Yw,lfT_KMsdgn2!늵**+04eD8qNތ;jV HdAc-e1vj;we"C%GhW=СC1$2qU7MXW"ŭm GPk/qsBDFBёH>Dtݱk hC'6̙þ}:仳H I%3>r3#չnU'x q<5vU\J "yJNsL6V6 kۿ/lٲ{x#zDQD$$)'&VdɣΉcG>[wDh,\c4vlFΨ<2֯_z$.{%".Gݥ,`Fxfd}G&gM[Ni7cK2vi+L;7o̐L5ОH^x!7wc}\8O?' !6ԤtrL0ohSɳ#M v@!뗴?!sDrw!ՖsUM 2ɦ]cqȕh9믿: }8ZRZa" |@nۙ" Fn2:t*%A4+1&Tו;[LLYr KDQFe:L{ g5\lhTݏ1MqÎ?!W>oGDQE/ ?3+Xdi " ѬofƗr$JBȖuET+B|1)WU04ՇkĺªUMK0DAgĹq:bp9c|^(K JtO򹇷D$QB;'O;'lד3#wo,ĴZ?d+·*6tC]Neu9cyGrrrt8Eyh'>ߋ.ŋ oߠ 1۾l۪~%Ass:佇6բ ҥ+v4 :;&MUrݔWUttZ^ ߏ~ ϋ.EVok;ҪMw#2 )1F=T1{2#)Ը)+;b]e y߆՗,9TS<]WNU]Wδz(:Ņ,$.*]9aƻPUk.[C|l1xb=$J䅐s>ji"-,2)I1ׇkws&,00L[jwۍ/OQ^~2zTME3|}'p,ޅ G[/&Œ̙9,zOearOZ6z(JIֳa冶<U5$'5IYaWhd$cwx- 0' +cd^MoBү_?rrrHڶd'G/wj=U%Q]̾qZ ;wѫW"9934U8i q)ȢW>3Ӈ**f<N84MO]ֶ\9Ȓ#B4D 3r`b4X<L_FP.JP؇~4]aE^uˎ[lQ~A! 9X_?…#iA> ozqS[_Rɫ=A`kI騚´B@nl?|Ԇ9|gMU**G[X:Xw=AtGs:iĸzSΤwZ&;nɃt5~9|d_sU5W^MF$DAF%҇6)l2 .b6UJ0kO? ^>(キv§SU[W(H̙i-!FLBJRORSzRS[qT/G\nPkkٟ=|Ap˞`(+͛6l^{-y ={QW令`c9fN!9qNYjxdͶMzr|7)NCz4t޽gyɓ'_5/^2VZW=hOՔ`Y"μy Q@QkJVr$Ɂi!<']B>YȲđ"K|oF9n wW:5 v6d㯣b ,9&{V?>ƍO?eӦLIhD5`/<*E4GvR2Mϒ=q.L`[?ode;X- ʬ %JrIqM^Jɖ?~<}נh;1aIz`QeA7".2ҲIMGr89\'h]jQIxƔ;7{SUS?; snm Z +qכOO5&RN kZ$}t)5UWOvscm i$ĥMM7&:ic3x{*s9t8Ēl Nd $&&"]SšU{x[vքgtPDD9x4-@ ʪY~Kjq.g_D@IpaZUucO?Ǖo@U}hIA%x K4r "j{֗ުvc YrtjuCCDjM5 +w-r46ҧy_׵k1}`DTEF2Ӈ َ(!"~Ջx)`yj ]<_< >PUkyZhL㖶(;w)4%ǚDTݫkQgk&Qz& OlL곎#T/WK[>$yV @$Dgej}nSX2SG/"`4M +hёcACc+X-i٨_q 'zȼ't]kd$g=._ӯLʪ )0ubyMď yFrJjb:$U gL3d(#:lFy#Mv`+&\EDnT/ƜMORFC:)/i&_I0 Aq&s!AAψ$:O[i$SK0{Έ-t4?&ۻh"i rE _9Voy#4e;l$Ilc >He9-?/(0+])'!"hGtzZ`?57f Gz;rF]rXrUi[1 0( 8P5h~[絃6Ņgni%~KoFeL@y:vWCL 9_ZW&?[ApG';,n i𗗣S)vP(oEpuJ5눢=H2y>~34q|ءX"_4&rϵ/XO@y~,hSXYƜ>H3O3=I< ibADd7v &O'xlHsο{o'0|dƁ-=_ZFfVdYQn63=g`1EB&O'%WGA|լGݻRөQ4 E&qGv֘4t9WtIENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ(   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU*j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! TTHmj"*_)J[j#jVkUW֚Ԏj*?uUQ'QDTkMjIZ! (WWW #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU UUTTUUUUUUUUUUUUUUUUUUUUU~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???ތ$??TD@`d,@!@?D?D?D??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 176PNG  IHDRc IDATxy|Tξe_IB!웬 +uZ׺Tkm?u VZ[q׊( ";ȾMvqg&3d@kL23g<9*4{6!TZ̥t ΀,$ }#fO>7/-?o1yI6[!!BT'*TP0y5=㓯"t'Q ?I ڗQ{?_myGj9+I !}\JDqw__㠓'T^JB\d$K%(}TU=D>>U Z~ *CZa!,}|JߤAT&;:IiMjAoBd$)>=>W./:Y,$ s@_p3/6tdb60mdH"x*v"qJ2@M;{փN!lc >$IEAQ%@@(~% @Ya6}p&c{o[&\HR*BU;%(j |CBBud=HV&:dI$_>P8zi1ύ(ʲ7G#E (1PQUE$MްT MB~.O|?>A7 z"PΣ{2DIU :Ndm5kۖ&_l/__m@#}t0I$<$}ߌ g2v, zUU W<޽HDm]2^]1 r?GB JU$G?Jr+߃*H^oB$fnUO>4dIǪ yG?=/6~D@3>RۓS~˘Q (~voz'{"lRf*: ^o&'mIg(ܞVZپo[N<)st3.e>I&Pw)`whjeX1H}vr>[ii=[;8oTDS'Wm4)ӕ@R;14NևOp `Ͽ[jg_Kj&̙z!K hBdS%l$헠3!IRƤ/^EBx&g5`6QhB9`gS(I@Sݰ՛ L#)͝@@JpV|>~X$S(jvDxU;G_)u1 3F }_r2Q>[zKX_>ˏWdF U ZmuF%>yG/ 7w4G^LF X@pkaW,kש $ ϭE&*uLz#@ tW TpnNKqK ҈sd@h! Us! w!mTDq^#t=II 7U `4U\#W:OXj8rg16oMNp1aK(Kڇw?wI #wW-CFs'Pl$$/Ɠ6| %g/z|fIϟLj}Ń tʬx[=,|[mԘynAE(hRPhۖ!o8ˊ&Q\I]S%PBMf?c )4WgOqy;VQlF}%v| "Qӽ1}ܩح ~ǝ i㯣(gIG_$B |DxmvpCBa@Wp=՞j q7ndwv3.=Ē $u߱s:;f,'rͯjQ t:ϒ?j1^Dn`f {og$:dD48tPI4cK^X}ڶ-gO⬳:a…Q-[Ǝ;ӟSF'+A9C(BcS#pZqƎd⫯J8./sH;hOwCWM_|1VlVYR(}&(VIY? ^<үYvjjyᅵJ 1@1^)eM ^z,[TҝN8Uxs!6=pjӮ aҨ,bL7?ɸ餕%1O/8$:2$;'tH ' gڴ&ʷ@Bn~$I,Vnu]BB8[5+kC:::8زp3 eNAUx"BIwL FG#v,6K*)LRY f.-2;zh"`e˭kшcwkIj@Du@uu5#il>@KĶW.qJW7Ur S ֭~ᏺDr( -q4_EVB<ĵhAfk~{ ??ۭ3,IfN!bb7ngo;ͭWmf8IzTj$NIK 8!X0D0Xw^ yy),Yiy~S8TW;y3N8Ky_ٱcK. Ď!8҆Ϧ /wBPQO/]!I?x ɎdӲG>͍7?^v8NK`yʕ+9c׿N:t(!4mebW0ܙP.2'b?3N=uɵy'yݷzqgmm q꫰qH^{Æ QGX@cDþ~&EO;l&ύZBZJeHwsϝtC5vS5'O_ojjnk?3bsu8=d=?Gqiumݶ8}vߔqMy׼K"}aGǵM[ֹ _{/cԶP̣:>{Wsqg&3'''湝q{8=]Z]acg/u)w>!T$ʯ;$wOZ8iǛ6Uzu9o?>FSpl෇z;'x:.]]w݅dɒ% ]WG >kcs*k5cOM8GWI_ $hGlYsfIE,D=1W\13=ϯ~j4|\~466+V'$\w(Ͻ+Z]x.dY$5\n@Ew%&%LhPsUu; Vڣ϶8L-ݚs-ԅ/2%ҥqSEZϝwW\YXxq!#ݥ\O}O0!4ez3[g_oυ+iwp7;w6a6N:idR}Qn3hO?媫J?n71M,_~]AZ^5}N碋bJmuؒՈj\Y# yz!s-ZQGņ ⢋.{J !TJKGfMt(Bc@ZR. 'I}#kc{%%P۸}`sHMM/`zjr gʔ{ ~y!gPjqM7ێ:Ey#1̸oRRtٳd3]" Q ?ӸR'K%&Ǜ+}Eoд0g N'?"@f--i#QPJees1s̡$ +Ct|~뮋ޞ dzڱSx‹ (o˒$qYM.Gnôb@h_my37zI q8>f͚%uם@59Ed˗'=M7… ]wi?r{{6lQU>Xd 9Evz1L^Nv7wZ;K~Yϟ~AU~x6FΏ'Rݰ! ㍏Ziko`4D=(\.z]ߏon]E7"ڈPTϏ=jh/ h?[fL<|7'SrF{8q5b6GkE P]]' xm&}E";Ӳ=~7^;=s\*|O5mH&ߟUq&tؓggz2\{>7k֬a1~|n^x ^|emL0&Eˇ_^Jxקr+ִV $ g,y: o@8넟w{alT{vO> hEt7W"brW’%Hq> h0c2L#8=skހ{頩wR0)hٺK~y4~sY_*瑨iǞYs絏b^up8,>~Ň?C"x4.EEE̞=A=xCXv-l] _v< k=PUO缸[k/v䓯q>0a Ȓ̏N-0 TM@0x|K#QEwpee%| \y啱4%I sG0~c(4Ac#FI>iSh@;] s=k8GsOreFK; @6$I;/ ߡHcbQ'a3s7\7 `+Wȑ9A/BO̙3)--gIx͒%w#RSR1̸;ک鬥 36K*};TTnoIbԐ 3t`a4:X vS UσqS\I8[[x;bM6 zF>m΋#G¶mqF'2H Ҫ5\ɽUULݞ*\6]mb^ζ%)XL,&5lΏ-T"dN:h. }386*Y|sw9o"ŖR P^^NOˏ>$kyG>dۃA'4}5.!ԝ/}́ vwg 54G6HXk= @eσBČ9w~IP|AzJV9(I,oywV}/8`I '/yfZZZ+lXV, fBϛxr iARL!7Pu 1rT&36m̙WEk"~^IDAT  dZdfK!P z$*IHtBǠ7"!sG!T ߭v؀"S75ߎ8'sYγׅ;`[yNb*.w' -?gqCؼaFiFV[˷FQR)-V@$dIkhЛ@HwmG$ sGlܱ9""8O&7NL|؛^"ܩJYÌ?T[)L%So.oË'c6[piw7䉳k׿[ʒp|O?}ҢXMd__*h0$sSS;e xW6|KJ =im #L'3u)yjsNI[+VOD=(C'}L\"ϐqI$#$sS,zA} vCk!eU8F0{4w٨LV! XvfMZȗߊF㰧nUd]5 >q8,_ƌ76kͭحd}U)yJ&b41,fcr-feeGx .rN ŞI^3 )_I|QU $21FN^f FanYCsH62Kh=TaX#r=>6w3_WoZh?1fL(boX#v]Ϟ-TV}͗6 8VW# ;itVspEsy y>sOu5`Dc1b~"hP3='C\U[ŋc!"4IԼEBQpRlY,~9~FiD&= ɡYˍܠ7*%S}MFY1ƴuJj4{"*Ν;>3<_=.Ңf5@h"z% Ɇ`Z0uF&<;5MF+B]Et&O"\3Fiw%S).#=%W>vtY0i15_h2X4#~ <W_}5"I ()hj鴗$t-Lա ) .9>Kk ™o;wgHLii# G7صƔu}+dN-KOɂqw8qy4!8#<_}o~n7GoAo\(w$PiiKQL/॥WG+\V6,ΥA=rohN56swR0tOvw muݒ]6 |d=2ZB6஻"=]5ffJj^IKP8Rmtx.6~׻MM GU"} viEK[Ϥщ ]MDozw (~gσ`@G#m*:KSO宻 ?plo@ɣ*P?j= G "n7?*vEvw 2yWmBZƯu8@UdYF ?& ?Y.y[J|ebj6LU 0eL| *Cr:f̝~1 f]p,]ъ$_3pɓ ~m.b*hs5v("EUB#Lp"*[=?/~wҢ II% E%S*nkZ~6j9{ K?ND7aEpu8\<5WR OM{t]1t:˷{\tm+> ,{?_+: =I^WG m&~4'6@hbخQoFC>[juJͷgЛ8 9:YifXB 'uFkx뭷x͛Ǟeϫ9'lؾ-<4V'0x^2%TEY[=4q9cI !3uFUU D~1ӦM&yZ,ueDC^@/sނ,zٓdqwlk1s1䁠0נ7Fn X)(Ȓbm7e^Fz&c'ú`1ۑ%%CgD~'HKݔM=3E謢%K2zE ~&N$UXL!c0m`>&g U;htVajHcs8f3t}jsk kZč-Ut\VUI0cL~m&.Dem7WRQ۱K:V{y9:2HKaOV*( $edcgZ1ٓ%Şu޷1fb ݑKvz!ÑKPҒAc0*jܟ()lb$ݑGk;l$ r#Kfj˓>0z1ZJlnKb!duX+'iԛ^[Ö^g j'Sda4ZHwbw ?&+3O;յT7boCi zS#Tmdc2ZJQoA [v GD.%Aq #ZoK IPv IYgMdbƎ _SmIii.'f|#C" }kXMʫ7'3~0'Z0lX{(U^^6he$%TPir'NٴM>BuɟӋ"\i?ݞ6 IOGש@~* -{`̲N3~?P׸O0yke'ur,kAfqwZ@)ARZDd8nHV4jrVv; eƔLjM?t:]>(}4;*шQT?`dɴq)yeCPn`r?Q׸'O)NzȲ |-m(J<.0 4Ej ζH0vجy ʘҠ |-NN {E$O Lh W;OmSEP5"E(%h[T0e_w"?Q7 (>jf7G NP=+JᕂN hD82N)(}\Rl'vjk斶:lTۊfA*¾z5AϾzK(K'  8N0}𐾓XIs7>m~IENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ3  ? UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU**j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDTQQ֨?W֩kVUEGT""J֢RUTEDDkTT(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?(WWUWfW W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQBT~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???$??r@@`B7@GA"@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? 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ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ  ? 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ZG]UkkUUDUDEGZ_ZkUZU#ZUIUQ*֨?j*5UO֤(WW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUB~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???$??K9@*8@Zd@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 21`3PNG  IHDRc IDATxw`U_ܙM@=4LAQȨh*X(WQ~-묫(A7In8 C\sLƎ}$I7~9hB:s!I.W~ѩ1oڵة6&ĥխ7v 㢡! v蚃sa2)FAzJMoIzړ;tt HOn nCB1`Ӯ$Kν3+L8q'b칎ۂY,rӥT70"V+^GRBA,f[30k:ruʚbQT.1cN;Kټy n_-H e'~G܏'Bt^H44Mtx}nNYjq_񒞒I6#I2~ŇY6'1tLl# аZlm ̘)1'g;eDlB@wWLsxcml7/1>XupB*M}%~'$5W<l3eIeN /US$&J=O9y^} N}[/A Bm9Fk*}\nMa2Y8+Lp Ȳ "|~o}LΟ$ HA dBLHHTSU[iȲ,0t"<[pmu] !>]"}[4u4&j˂Cл@vU)m]v/xlv8lV+$>,CWya*sUMncZ1:~EFOLA=Oф;?`ywt=7::.#g^A]=xGwװp]IJgB4MmQwU>8qq Ɇ$K9X _VyDHNN&9%V~ͫ]Yʁdf&#w[ F 8$@Hq,XVϯ;&Ƀ$=%e/ѫ1$I#b&..#8UU oڿ)#Є>4?/ [a%&YW5!ذ$npne{>շG7.8]! _up[* -AQ}\}~,1 fކH U.4$T8. M% ůz}^lV6}nԻi=(!Z7I{cݮUFjRǒ!(,CNa|cIT^}u3dӐxE178 2X&;T?- #eU1w_ߋ$8R%٘Lpe= IՁFUU$IbrG4z;ԇa'Mzzx^<ߛQeub{xǽ7(ʕFmkֈ%N_~g_)}X|[33\1>8n}#x}M@pGJw~UAjcj$I6L@rn'yu$fBfaewl߷&x'gs5S*Wrm h|#vh;ΖQT/g܈sزVϽa긋e`a#4WzUFMQhJya=u޽z=x^F</Ba}G_)`9v\pA>ӧ_kӗ+7uIG:tRzF|\rpIYĿ?~KfIJBfUSPTun'u NqIj>]ҧSZF붾n0GÑҝHĚ-qٜ?ܢ !IKܿʚ"J*PPqԑ?# h@]C5e{pW9 ;q@7MUP5?Jtk@Na:wS[̘1[om;AS0{5H_^<8g,{{VKf َ,=~7{$IT8\]~GCK^ w~<z ~2ԩi%=s)$]ٮ6à1MV& W/OϾUqUFqs?tzp"і]D=!+!G21rdf%1v$f[2:$I-.GŢ IPU[JQ^vXw̯ 򦄤{$]cBCB 7}aN VdYbڴ!'cIN,R'@o@e’.s8.s>jW}ctԑ0fݿ69&'11d 26HrcNP[I4ԟגgb4.y-೗Ǧ>R3tQP"ϸH gmk_O;3<ןIB|fVNG3VXLVddhGxkoVV6~ߏՔjGQ=x Թ$%,m^f'$Zi*OOF$匍g"*wh\ lʃaއ'CT,b Pxtw"IygOl[$ 6|^ dgJD?UUP?fFṰ4Mh5zCv ,n wc=J*LD$$I]y f4ǜhꭆi84%S #k;)d}ҪCA"IvG}O|+?%]y]Ȓݏ/hܖp_$i*NW΢׿%KAHM͎_0UP*%યlw_l3 Z4h/%R)&egqdٌdFTe_CC@9} TYS0}Jw*W}ծ2ٌ@$!øfl6= LNij8$FP ]ۿP:$I&_>IQyp}~)g@fza{Ӊv _>݇㆚r(,BM/5%ҒZmԕSVya3,zw 5Q.REUuBŏ_{o#b>W%91{̨)8Zx=Rzj?*Ek8kdSUSQȲ@h tω pB@W R{7=aW#%Ám>8[ 1AxfםPSWήCLl&Ζ8ImQ~=6C,~̘9w"{l!3у`d 8llJyu kGi-[ނP_Fo=I[@Ug"~f3, Oᨦ(50*j7X\݊Cٯxmǻ5vo_ )!UUx먩+uMR|wzKr ǭM{˼yL%R{!zj:=.f #N !Z-B4J^O'W]8ʃzfDung?!.'MFT>qZ]3d[;8n{oa-. ⡮IUmIȇKvf$} YoIN$Ya*+Vꫯ9vi&x@wj]9,| *kKӁp"  v!OF$}ӡoH#N,S[u?8b Fo="6ˡ sx;K#f2Et] #SJě>~*& Ζ@>$ŧa̿o`ʕ|>.y喇~;/j*VXi7gK0j*lYp;ܾ#uQT\ !xl[M2VPttUh ?ԩSټys8=2|r^`ѢE͈`2DpEoadV B$zʥoI,= ^M& MHv f+3.weΜ9m㪫bرgNihhu!G>Ԋw*בFB\ BUVrVFBrP5?WuABAg8P7RU[JIA*c[Xjav>yy̌:猥dg 2r)<[:q<ҥKNg8p{\\XE)< C$f~4 P2Tq^,눼zyE?Gp3~IFj6~G}c Gndf/_Κ5k;FDG9HNnSKIjKsWsͅ~6]4G)`h7udɡ,E3|$Rw+ d֯HJHï+|/-lӦM<|Kh!UDo4܍.$ f`S40=I,U5$8RZ6}Jj YyT8 7ng`1YPT5EL1(>1xx-Jv4-{L>}"VuO-ѽG6QU[BA.*ksWA3']$=>wLW^f @!^#/<&2wir[ իC;/% -Xl>q<n<(g,6K}=Kۅ)KPUg]EYNvzd7o 3T۱tU|evٕ@Ĕ3&'ѓfw7c< vSVyjwubk͚B,|FUM jTϻ3?~'RE1pR 4a҆/ƲPzq,INW)IԻkhX6Ə87")R,sƵ Uld ґeqI.ȑ#8]eY@j VfsAii) ,":i@4ǜ(F7tv7tޖUFum)6èey=VMUpb0X3Ζ "‡ 8W]u۶*(! y@0jHVE'br!Wʚ"* w;YB϶pںJ*]>wWtH2z2-Z7tkРAEH@vE-l^wD̪¨D'!%~+]. 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WC5]KUm)9!222&7;xrU/7_[IIq9֮]no!4VyjG;v,snbnA` W twSUSB->X"1pn $Y#$4M Թ]جq / P6N'϶z9iOO!BrM7׿.GoV+^0 Y6'ң߶Lc\u`h2'$l8^m<,w"&ٌV0^TTMEH:ŁIIz,[ sua/v/}HR|::=/Zp!SNųɂ$.)dBFo=wqZ=W_ѥu ' u PɷX-6$R29r>QO2`v[<?+GKek˗3J((q|"UJ) IMjjjxbb6=ֹ\BQMdd8{"IIIg6[#B DhkxG I _sƑfdB?#̲% ~}\UUav,B}U|ܹsy뭷zx<ԣi+ @QLdܶ@xl M鑶"?cx"ٲ퐜q#9!j>JNϟhFn_ڟ&;s0S'\*(QTwִ/ "_pj7_n~+˛InzMA&0ܟh3fG)N8K1-nx"NzFbǨFRr%wt6Ku$G}s\*!_ŏ~A}xt)f4g^mv|! 糯G n0/g'eee.[S:Ѣ量ü3 ,X,f+ يlĈm{VW}E1y%/nϯxha6ckc93gdѼkɼggBN$H#;s;q{]x9g^kJzC@W8ĹS~IuSY'д "QN'^_#S\zN4#$X|uB}o-˲Iu u{\K?=BCO?_o~[.~_ K<~*I0IrOyꩧx7X~=/wH g3aOeh6{~(+ :\ U/F\NbQ/Gh -#a$;pٮ,xf3+Wdn`C&ܬQ8Bu`l 9ؾ};.{/{ow" +74s18@P(E ɗ끄"b,2-[G}ĴiӸ#p <-& r bB&uq8묳"6hU,>gˮP`1T ?iBD@Bz?s1uT96n =>9st:;ݿ4B }nBlJ+݃nS@Q} yUm i}u')@Cщo `޼ymj6l@BBQgeSv))))СCf:nCUS[h]H"p㏓ʌ3"Y`M\.˖-G)CCdJR8X:߹0`xzeÍgz|lݺLFCB!BДIOdd'kE䗿v7qVO|L1>?axʰN8FΉn ;-е^ G_?~<,Z Eӯ#Zn-yf . ?F(f~QoIAGt!%?z vTc=!ObFyz3zӃCČ f1<==A!ObFyz3zӃCČ f1<==A!ObFyz3zӃCČ f1<==A!ObFyz3zӃCČ8Rb IENDB`move=1000;blend=1000;1UQR??ѵ#U?֪?֟Z֢ZiUQQD֗ԏkOZUGkUT֤֫ZZ֨5֪ij*5֟ZUGjG֫ZR?TkU?jZ֨?KZjGZjZ֢ZiUQQDkUT֤֫ZkTkTQTkUUS_ԏkOԏkOI!$HI$I $BI!$HI$$I$BI!$HI$$I $@I!$HI$$I $@I!$O ?mp fB!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!LȈDDUUULȈUUL̈UUUS2""312"#3UUUUS2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUU0LȈDDLUUULȈUUL̈UUUS2""312"#3UUUUUS32""#13333UUUTȈUUL̈UUUL̈DDDDDDDLUUUP2""#1335UUUS2""#5UUT̈UUUS2""312"#3UUUUUT2""#1335UUUS2""#5UUS33""#5UUUT̈DDDDDDDLUUUS3"""333UUUU3"""3UUU332""3UUUU32""312"#3UUUUUUA3"""3335UUUS2""#5UUT̈UUUS2""312"#3UUUUS2""#1333335UUUS2""#5UUT̈UUUS2""312"#3UUUUA3"""333333UUUU3"""3UUULȈUUUU3""#13""35UUUUU2""#135UUUL̈UUTȈUUUTȈDDDDDLȈUUUS0I/vbinding site for residue so4 a1148ac2Je1vbinding site for residue so4 b1147ac3B\1vbinding site for residue so4 b1148ac41vbinding site for residue so4 c1154ac5D^1vbinding site for residue so4 c1155ac61vbinding site for residue so4 c1156ac71vbinding site for residue so4 d1152ac8Jd1vbinding site for residue so4 d1153ac91~binding site for residue so4 d1154bc1 1vbinding site for residue so4 e1147bc2Ga1vbinding site for residue so4 e1148bc31vbinding site for residue so4 e1149bc41vbinding site for residue so4 f1153bc6D_1vbinding site for residue so4 f1155bc81vbinding site for residue so4 g1147bc9D^1vbinding site for residue so4 h1155cc2D^1vbinding site for residue so4 h1156cc31vbinding site for residue so4 h1157cc41vbinding site for residue so4 i1147cc5E_1vbinding site for residue so4 j1147cc6Jd1 vbinding site for residue so4 j1148cc71 ~binding site for residue so4 j1149cc8 1 vbinding site for residue so4 k1152cc9Jd1 ~binding site for residue so4 k1153dc1 1 vbinding site for residue so4 l1148dc4B\1 3LWZB1'C0C%7 j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZ_ZkUZU#Z]UDTDFITQZRփHBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB[jUTkVUiH֭j*?QDj#A$EGZuU$F_MjGUV֨?Ej*?GZE(֢ZRWR#*?Z֢QDZR5֭jZuUEG*"#Z(ZiUS?A$!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!?Z_HjZ֤kV֨?E֢W꺪#ZU#ZTQZBA[j#iHZGQQ??ZH?֩?mjWUZuQQ?QQ֨?W֩kVUiH꺪֢WUQRGEF֪ԟx<W $",tm{UcB f2PU" "#5UUPȈDDDU UPȈDDDD@DADDȈUUU 2"""33US5UBffDDB""&jfDDFf fb" "f "dDFfȈDD3UT0B(9̈DDDDL̈UUP̈DDfjfjD@#5UUS33""!T5US2""30s0a333""35UUT*̀$DDf""&fj(EUAUUT332""CUT32""33Q2"#3UUUB̈DDTUPjDDDFj(332""#135LU 5PDDDfffdDD"""*3""#1333""35UUT*3"""3UUTȈDDDU UT̈DDDȈUUU  UP`"""3UUU ̈DDEPU ̈DDDDLDLUUP"""#135U3UT jffdDD"""jfdDDf`f""&b "&DDfjj̈DDLA5UC T"a ȈDDDDADȈUUU ȈD@fj`D"3UUU332""CUU3""#3330332"#3UUUBZ-~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 13LWZ&   UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU *j*?"5֭jZZTZGփH?Z_HjUW֚Ԏj*?QDj#A oT(#j#TQEF֤֯h?! ZG]UkkUUDUDEGZT_*U"*UEJU_ZkR:UTEDDkTEQQ5$T(W WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUZUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU~binding site for residue bme a 151ac1gi}} 1~binding site for residue gol a 153ac3LPoo 1~binding site for residue gol a 154ac4Y]`` 1~binding site for residue bme b 151ac7gi}} 1~binding site for residue gol b 152ac8LPoo 1vbinding site for residue gol b 154bc1Y]1vbinding site for residue bme c 151bc2j~1~binding site for residue gol c 152bc3OSrr 1vbinding site for residue gol c 154bc5Yt1~binding site for residue bme d 151bc6hj~~ 1vbinding site for residue edo d 152bc71=1~binding site for residue gol d 153bc8MQpp 1~binding site for residue gol d 154bc9Wrww 1vbinding site for residue gol d 156cc2lm1~binding site for residue gol d 157cc3Z^aa 1~binding site for residue gol d 158cc4%(./ 1?333333?333333?333333???????@???{z$??A5@G"@`%? ^? ^? ^??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 22$PNG  IHDRc IDATxwTǿlEziD1[|Q$-X%(Q1Eрb "EwKGNq0.̗|rsg~{QI4It]I4iIx$MZ}zKtfR'ųd,˪y> ;v^RȺ6mZN35^UHջwo9eʔ ydyGjx5u^<?=wnvѡC4M#33xZrZ`ʔ)_׋L0;SvڢtR̙3YzuԾ;Pib:B=:^ w8;dx+5^SxAxk^(((((LɧFq@AA"R @Br vQ8Stp>%\z&0>E?{cƽ5@1@1 L$?q900 sV`{p z3xztJp ,n7lvp4cRw;sP A21E} ȥjKw}iaYrj(!0f'iި=}@HYwӡ9XRp%Mvv69]CN2?{?g/UUiSj**}g"Jn#dI1ג_sp;'#3Lt Ä.J;2|y-9ו=/xݻhۢLnN6ٹf )*.GH~O?47nߎ{QU MQ[Ƒ#)+Q,2ܙ]Y ܮsp#7&'' G8r(vOKdg'Õ˕KDa>uu^%?{&MWˑG8zHOm۶8¹MT o<0,QR9.4+/%cUMw8u(CT#!ӴkyBV_׃z6lHߟbXASmζA0ǾS\\DqqE%Ŕ1 :}q M5h>K =Lwƥ4UQ5| MN%ZvWDU5< RXOaQxvo=VTUs4EUQ09;c^H)f]uVѮew~8qST\aGl۳2< 6Mh{NоEɯs;fÎ% ~qnu8MY)p<-wB]n=?!(45\N_(X|Lwfk:A4U9ѣ}6sA~=lKY _=Vx+K|(\'qq=ic^(E %ܫ/!7;&vzy摝I{l`AL3~lv"vg$##,2XvṈ qpy&Bc++|xEB?"qW;s`?GOel+^ױ6?e>FQUVo#( \?ꡊ/^ QsrQ^}>^JN\3 ӏaAs\˦QUMpd3bҷʼy7fe]ÙeY(}dl q2?6f}4;&'5p]@L/~'91,'h\{Lq#]iNJ{ٞFLXM`ճKk[v/tY8EuF7ftǞ:9h37]RjHH³9C0|}1h"0bYb+%>=}ϪMaˮMg^n  7aޫ:P8I+f=a3Dҳ L0 LDXM6G>*B8ءer?gAl [v`랕l-BXL[[o. rgf8w9&wcxx|˥s;:WMji9Ps~+QUR85e!0du`=[DJ2r),me7X>F_szw[PGfvWe͚5ܹÇs1&MĢEK.a\s5\C^{#G|\谠(QRgΥqTٓp/a`3VDHG*Kc~4ͅ.,{/RJ 3#hzV4՞[xWqyf>Ә^{-[laB{I&Nxexzx^=~YUeN6zEx JkR/a6falرo>RHط:^]hݬKԾזy(겅5{ۥۺQ 7ejk.reʕ;6#F0k,֯_'pULԑ.UB6K(.)@*/_m"%:,)"|w/'0tXA Ҭa>Q$#MâѴh躛m{a\2\FfΜ9L4}`Ak^m>B&g5Ey0; ϣy=x}{8S{0bD#Fp /}02VU~TvGsk֬a~pB>ͻn>s*@ 9͙ͯ\].,r&y5 خ-x(7S#,c,kXpO05}˺C ?aib& 2ܶˈMv֡1"O:. ,_<Kqftw=P j/"gW_曕"= bY&nn kL<.zti|nl1wxn,w_6Hi1cFX03f̰w ~Ǯ Fo4iL5m7MUXGpջiѹgs/I<.cAaV <oصkWiZ ͔rfU%Ǩyj 5anl|ͻfU{qzQt` `C\mų|r^z饸=LJZYo̫<~8BX_iTJm{ӇoOqq1tԉݻwWH s,MWY]]Y*1%L #U75.֭]bEJ4|a.Y `EQZz1u,ZEEabZJNgԨQň'U _* b<%'''fc9rb/~g unׁhܑ_axcnռvf+!6lX: A_X88"ri<eIv;A&.@A#?447L*^VRHLHh6PcI5 '2bJ9?cz;]w;ܸkc[ݮL&!J)0M@З5N%5Z\ dW=tY勘>6zr1?>}\ 8g;EAJ(IѴnEQɎ=VO5*>@u3 `UEAa4MS(5|>?S/^yx=XXffK~i{ VjTn]؟_2D ?~˦gOşTj+}N>],a94 $w?}VL;>ch&le%#CuR<_5k^{mB۫V0dٺ~CZIz@UpU-gCʸ9x]Ix[=%Cv&;; rcJrhq}ቈ*ZGy|}*5>I,_Ѵ 6l87쥠eW''?;m4, KWuV<3gdΜ>X|[פ B ),.(1ǹnhKRa,-GmmVy32/PuׇU!EB gԩl!x=;ѱG_t{8i4kXH_W ƃ>ȑ#+u%U`?\ѢE lBnhժUiίKaРvF6wh B"iդ3G xVCy>|[nۍv:O=۷o["" |I?`X}E%Ÿ]C8!q^+2Y簄?mKZtb <8j߸q㢖ΜLO}S=fSTnذ!|fݪڡ@ ^1@ i *J33ҴYwWĩN5A?rrƢEPʈ5X)fφq;N{h3CWH$ %vc߼6nY#î:/`ӧÆ QO 0J _^W7gG H{Bp k|9oq**^;=u~>h󓟄?C߿eDtO tR믳aoΉ'^08fƏپ};[ne;YxqBԦ7}gc>J͛W}z|Z'̙3'*jʉzJ*Z| Bif|R;֎ƳxX)VpPVWN`O :aN5Ճn6^=1 x ^xޘBQtU}!,/g kΤLxO#jիiժUkߑ@i@SEr?GQۿD?^3 OgU=q&Ѽy}yڵ+9994nܘ ҮeϰN% 88IAi 2;K۾y <犄\uL3|π[ACJ~Ia…k׎cY*]ql]p3B b\zFDd `""6ZF}t\ ʸK-U(]/:]Oˑ?EC"( B >Y*~tCo2B!x\zMdebAe' uM+HSqיO Hq,!~G?Ǐ0xܮ,\tYdĉL.4쑃!L.Qi$PͻFJɡ}Q5İv-MWEƇCؙˆ?#Ý˕[@nbJ F OP9N;U=/W|RZ4YXԦ7{Kf~wKgr{^>ׄnK0-<_'!{fkU8s~ݦ啷q)FQ`xxh3l{ z"k!)l+v6d~|=CTppw6\ܶMDWuTMCX"a#y]ҨAKTEe{l h@ˑRV.Wڭ+/9_˥mͩTq>|o Z5팦jde';3Lw.nwi:da9VvAN☦~IDATVRJZS~:'!>Lhע{^&5ꀦjhFff.Ydspg:##^]Y!%+6_gm8BJ>X\ vҬQ;TUGUT3둕KfF.nWfTҩMo2desET: wKlc4߬NW6lH:Eݶ/.ݍەźm +VJkD$O P΃Kr4kPyߕK}1cHxrr%EH@;!w' vuǔ~sV}3|0rsg+B"hݬ[+߫Xt#,E j0ߧ<_C 8NAǨRM=|3FԦw8T(TEThkڴ4TCEBL71ov5kTdwD-5|+F筷&0a[lR\v-eo&}1CCkjĝOgR*GEn]CW#ϟYy͙UE#꘡׮EO=)*a$y-͜9E:H?`܈C]4ͺSUIx,ʅV5CbH)9Qt|?$#}]Ry==6!5ë 'cZ~6r񘿮|SkRp,{~< >(%|MM!([WU-Qk