+3.6-1h/data/swissprot/ 3O8Q.pdbdupa 1NYT.pdbY[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.45 Angstrom Resolution Crystal Structure Of Shikimate 5- Dehydrogenase (Aroe) From Vibrio Cholerae[/h3] [p]G.Minasov, S.H.Light, L.Shuvalova, L.Papazisi, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3O8Q" target="blank"]3O8Q[/a] [small](deposited on 03-AUG-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1NYT.pdb3O8Q a_3O8QB1  1NYT3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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{axLE$I!֯$3KǴZ2>"M@,-]FL \WqjhZQP+shTƬ vf/7F,iY^FU[yF.Sn0E<(Ih`Y.I-lC@6Ir pyO>—jy* ʊo(jWɲ1Q4*!| IA"q7y(-*SyT6(ڥ^HM* Y3,FN$iB ϻKAOaM^EDѤthEɆϻO>ɧ@ѯ"IRIs.Fyʼ޿۵X]mYE-i{?K|+O,*yNقHqpMWnvןcz,d}K=" (`$@g`Y fR:SpN(sU(JQ( ˅Z/ϋ${:M2wFyjAU)_ ?$b<.$їQ}!|\h|<Q(M(-xl.(qa,/7$ QJ^ qݏ"e1" bi/Cd,xEirҋܾENAeoV_BUD'uw(LHEZt]KO(0}D E@NK?}DQHq_jZư}@HRThO=1%A0"2{-& ~q|Μ-3~Xn^%jgȜC_^~Aeo>/SDF?i_8R++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES13O8Q6+$* I$I$I$I$I*+    MJA4=sV9ЅSդœَc!wN0 ,d‰Y2d "0BHDDE (XP8a2dpMdf;9G*"F6ٌdb()fXc1[Xn!v. & &D.fTrꪟO^[RMsQB53Op$ '=ͅAMII jI`SZ99{֭$I@P4=5-9si<R8qN{>p/!y*@Ґ4}`tc&W!0  JZh\q!;DxѠ 0 q+FPIH{mBIㅃrBCh ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@???g0(g$=?v|:R#?E?E?.E??@@@x@x@ ???333333?333333???#~j????333333? 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<ư)q쾼PCTJ;>%j0q(7L$(Y?to(H{F,b}&j\4뀋ŷ\&BW4-,F;/$z4@C?=wEyNDT, 3(ӟ_RDPN d c`Y7!'F @$N11'ί~mePC@} Ӳ%WGzq &q #j!U6bM[W Awmjn9Cݍ_ڰl2۶xOx_lkl= m\$^y'{4C-r(H@:w;z#3PM`הx; } t܋EO#xIng\PL j3ܳŝ>R)5Cv;hh#&GXR| na)~Ly9bVEap= pprN I72 ;ڠIgC~3QTl9uXY1~=Kjf#0Q,F5fO#EAz`* j]}Z.l**ER`Gx&P;Ơf ;ƑeS`Hhy6^}!dRx;3Fun:.;sG{~dy l9p2-^̖SO%Y:8nj[-O툂[1Qԋ'0TBn[ؿ?idQ 1#"BKJB@Ȼx\Q9 qBXUho_D=09x5i°ІRr`e .A^ Qk]=Z|ST|߲=<+^E0<ƿ۞/m(" za-Ħ9#Y-dx^g#'s_wkᗺ; f; (Оn|m0}[8SmN>߁- 23<~(- .%['xcO[q@We1Hl8';cԹƗyW y6 &1s?\[d#1zE`WCԧ+׬QϷ(91Mm202וea_ph Į홙d!8Vɛ"Sk\"?KFBB{(m"៎%k6?9l]w>j`13&873?$50jx^Ef$O 5} s?4n؁S!ThdAvlle(,8i0~Y=UМwt j$FҗCj$?f35ۓdQ33 ̹n l@'ĩ&ilV,J Jֶǡ+pr pJ/ [kO1bd2)g.Ҟ 3SL-{>^=R,wirB͹v,ܲìիcԚ=PbiӘ _Y; 0 kZMpܘAJԨ,B_+8&x4?l@ƍ旮.A5?Q}$88nwcev0'fw[uwy5v[` Ou!y0Y_d }G?fpxfG`E>0ڶ ~*nS2c~ְO)c5v31ǠU| `gq?7ύρy䞇x'l(R {o*򼭇Q xKPL~mHj.ɝ (.o_X~@ j$Fq!zfeea!Pk90Gć; *ԛT A$9{RCHYCbYFd#/%e= *5 ;Ix15axqݱJsƙ` 3``>-2ttq b8 ܌瞃\ .`23kYtvtfhv}%`}QLQMQr>A^țRDƅ(]DTjJ?Ͷ\aSfh0"fl)OѪmg6]x~|f%Z>s`TL<} <4KÄaoU=Ÿ}y'ɉ 9DQOGU8q[K5 ܏O{m:?Q2H. >2'^F&^m=iS[d63P,6̢D]cP 3t1k:NNxl/a8ǚ(BC!82T+܆5c| M[-1ߝu-K0j $&+ 4S l*V:$m=C~D8Z}lECoX"P'$p/DO!G/;o|sl[Qt_c](O'Z g:\a5W17jf-/'E%%䍀Ghս&TT²;g0 n]q Ъ}y5WA}* /w/+b`)GWrYKIR.iVrb2Ф+ڋF{MhZJ XmO<{hGXBB &[#[WdYT^V/H]JDsi,4ץϻ,+(`12mسe!yImKz ^x3vHw82Y}Q} z]"nGǞ X5/@O@w!#n/B<62n]?ϴɛX̫?౫+Vd6.EU ]4>8h Vw/3-prlj+^B Ө"q-[N*gwK>rw[Vނ_(P񈢪pMyx2}fIBԎBq2W`kQO@Ga 43\ dFBWl)tTp!~Z(D{ץQ @vI A., C~ 2g J niyWr~mpP)Z!/)!4n6Mpk[-8W*crPOT AM U(?ZyG chN Q-ŌBZ'N-w+u'Zd>AB,jŲ|J䠘J|E~& YKTwZ;;'N lF7@A $CP }iAtk>pY: =ؠ#+${w"YmMG{~^DDLw5RHZG++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES11NYT<& & < ֟i!Z֪HZT(Cu[HkT(CZ_֨P kUS֠UUTPZHO֖CԟZB뭮HkT(CZ_֨P kUS֠j ZKZZ֩?]muR ֗B??֠_֠jZJ֯ZԟB?[]ujCZBB?[ZZZj UT_H$ $I DH"B!$D! I H$ $I"DD"!H$HDHDDH$ $I H$HB"DI"DDDD@$I H$HB"DI"DDDD@$&u fI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$$DDI$mlDDD[ml""ImdEl""I$DDm$Hml""$m@H$ $$I%mHmm-m$DDI$mlDDD[ml""ImdEl""I$DDm$Hmm""$m$DDI I$ $DDI-mDDmmI-mHI-m$$m$DDmȋm$DDHmmI$%m$DDImmI""@I$$$I$mImm$mOwbinding site for residue so4 a 1402ac1u1wbinding site for residue so4 a 1403ac21binding site for residue so4 a 1404ac3 1binding site for residue nap a 1401bc6>A 1binding site for residue dtv a 1405bc7;>AV*1wbinding site for residue so4 b 1412ac4u1wbinding site for residue so4 b 1413ac51wbinding site for residue so4 b 1414ac61binding site for residue nap b 1411bc8>A 1wbinding site for residue so4 c 1423ac8=A1wbinding site for residue so4 c 1425bc1=B1binding site for residue nap c 1421bc9~1wbinding site for residue so4 d 1432bc3uu1wbinding site for residue so4 d 1433bc4=A1binding site for residue nap d 1431cc1>f 13O8QC++    MJA4=sV9ЅSդœَc!wN0 ,d‰Y2d "0BHDDE (XP8a2dpMdf;9G*"F6ٌdb()fXc1[Xn!v. & &D.fTrꪟO^[RMsQB53Op$ '=ͅAMII jI`SZ99{֭$I@P4=5-9si<R8qN{>p/!y*@Ґ4pLÇO xCpL<(lhPrdM<$: *:|`Ѳϔ:6|B ,20"H2>2>>0 $ @$ #fč0THDqQP0$ <F͔$D83ÅƎ$0`ٓDĆłX,:\ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@??+1NYTAfffL?p}4+3O8QAfff333?p}2?i i$??/?\ x6? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16APNG  IHDRc IDATxw|\g=gFZdYU$.! 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Xs8( w]@Մ,Ϛu6r O<%%%􈌑:Yb Ԋ<ӧOg͚pJD7.ۏ7ٲy2xms2Pv5nn.(Vđ %c!)Nb;o'| [QUMfv5k|'6sټm}Cvsڃ7Vse[>` Mw-̺4$G\No̾ _?J?Tw <^ho??s=7n'Nd޼y9뮻 2{l 5}t{#JNGQlL5O>_gn 5Vx\џ0˦;Hz)aY8;RO#/<@r:)tp yV\ɢ'Č}:tKہɤU|9g#GDQh0bηDLOm~W0rLWZ0Id.zDϟsc7]t)k׮~i/ߟI+ؼٿ?Jx!J Ɛϖ{JΙ-$E/ͫxXT\vOGZGZ)6p[ `VZ߯OR7{P xi1ewFXXw֭kM,j:H.]b奞 =y _d+:msBL"W,L]b/[{,Yyb7|[c*K>M/ H 7\6hl5V\V VgxEGaPq=__H{cޘ_ȓH~w>y~T7{uhr,Xo?Qwptv>~06ļ~g(6#Lc˻9ғ Mn7`~ 0f fzX:YZeRߕĻロ;_{ض~p*K>W 'EUu<d?z+/'#/׈j $a_E=cـ mТ NSy!'U@c~'㮼M^oS?׽%Sɂ'4 ΛC]݋D]W{E3b@u쌂 Z1HSOɇ۷Sv3+赇c'5[O<.m۷0MȘ'^Qݯ.x Ez"@k4;gHǧCujGj=aFHK$5MEC( ㆟/7K$,_'K1D| l#L驱dIevpͰrt IDATASn~Df6Qݦ9AE0Ls0ng =C[5"fۤ9LҘ4Z =&݈v:܄BD5XIC/D6gě‘[!M:Vb۸z:^\rE5",CM5VD#{OJS魧VN>D#][d74\ag2~:i[asظB=BHYbhWN u^1iݴ輮?'#O1(6sk4#iL+/--foIo$4^%4-NtX&Q7oZS0@SG'bZӹ[ѤƑ}(ӿC -O|ɕni,| |Lk%Ds0@CӉL{H&?pQUE3MS,Sú+Rˣ;Q;6aobY7X@J~??&#&ZFR=+Gi3I[ih%iQt'V0mܟ*G&5J `5Ԥ5(26&ǑOq=3*/%vkN~f RuFƪ`StGKktvV?PR0ZV6XBaz|).T6Q*q:c;(#n;U: Cy:M Êܽ[5bVWF:Q;eD zbC'f'<&e;l_ܔԵfX3Q{"O0eEQiI5ǏХ5 A$ڹ=B(̘O]H۪ZA>oeDO$[;JmC2Ht\#x`]acIC\yz!c)vl6Z„YQ4)&]j[R>Xnxh?TmXb[6.zN'A :͎͈Lbͷ ͡s>nU9kΰ7JgdZv'k2з>~.k)1$c"œ):~y:8nkkI2VPZĪi*rtSV=ec>"ꌄJ<"|Ciei<1nd7H4khj4I]5 dhY]*/T8fI!hʧÆT7?FWaSMW"#KFK Da5 qҧw<:sJ4 /SKQV8; xQ/9J N`9PZw%;(/[#i%L($Iu@bɳ{͖0xPԒ);("FEZL<%cBN("(~ f#iD0P#HrmM a0ҷomTO2j|*.AW}Gc02cjD(B ~M-ƚJsKM- 4'Kl{s CYRM 1|zT`ͅ$u!OIiF5][dT7D˦tFD \GS0zxE}REOC ,X[Yϭ6ef,iæ/ =/ɓGlA¼Ty0mT6p++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES11NYT& &  ֟i!Z֪HZT(Cu[HkT(CZ_֨P kUS֠UUTPZHO֖CԟZB뭮HkT(CZ_֨P kUS֠j ZKZZ֩?]muR ֗B??֠_֠jZJ֯ZԟB?[]ujCZBB?[ZZZj UT_H$ $I DH"B!$D! I H$ $I"DD"!H$HDHDDH$ $I H$HB"DI"DDDD@$I H$HB"DI"DDDD@$&u fI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$$DDI$mlDDD[ml""ImdEl""I$DDm$Hml""$m@H$ $$I%mHmm-m$DDI$mlDDD[ml""ImdEl""I$DDm$Hmm""$m$DDI I$ $DDI-mDDmmI-mHI-m$$m$DDmȋm$DDHmmI$%m$DDImmI""@I$$$I$mImm$mOwbinding site for residue so4 a 1402ac1u1wbinding site for residue so4 a 1403ac21binding site for residue so4 a 1404ac3 1binding site for residue nap a 1401bc6>A 1binding site for residue dtv a 1405bc7;>AV*1wbinding site for residue so4 b 1412ac4u1wbinding site for residue so4 b 1413ac51wbinding site for residue so4 b 1414ac61binding site for residue nap b 1411bc8>A 1wbinding site for residue so4 c 1423ac8=A1wbinding site for residue so4 c 1425bc1=B1binding site for residue nap c 1421bc9~1wbinding site for residue so4 d 1432bc3uu1wbinding site for residue so4 d 1433bc4=A1binding site for residue nap d 1431cc1>f 13O8Q4 + UUUUUUUUUUUUU_UUUUUUU_+UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ uU$GTU%UEJUQR"R֗UUDU/UVkUVQRGIA$D!HB $I'WWfW#$ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@???JJ$??Ђ!@`>-@̌3? Զ? Զ? Զ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3#PNG  IHDRc IDATxyչUݳo̰:,.l!ěk5^Uzykb4q&qD& =]uǩiOMwUW9U<9 tμeRǫs0UGo$l ABV0R!ưRWwλa4 )BgotyaSB H!R")MPKu*)eҘ eԵH)h+q_Co`V"P@=)ɥ3nBϼw[?-;Xc6n]öۚߢiu<ۖ>wP+"lԧ?̌Ǝ8MѭE}tC}x~nS.87f|=QD7FRwg>Dvf{wRCől}^vySmSRC+o.u6E'#y"L4ȡR#t@ B.˗H%I-#m)$-{"k*r%5%7/*gmk>{s9Yl\2BHi쒻 FВ:Ӗ@nhhqJ i%-ܒǖ"5hh (q)&?si3rθ$if~̞ڃ`@cFLe?qWױa#ıHa`Ez4Mi:ŅP\4i jt ՍGsR "4D$RUAYѳD2{RVosЁc5*ܮ"fnvsƂa|jp:D\'loR8Di)W_ֵ6 =l5Π.I9V]ױ Gnv!#DH!n]c:p,Q\E]c%7U:#l"oGH1&k/\i0P8Hk ͮKUklAJɱ LLcϋ網;q}:sکᨳp0eylݽ}3g? i rDs=j 0 Z$ß۶JaSI#G"#Gqjo2`yYhj#n)PG^N  Prӕs"@z1lqŃnyzN/iߔ6E!w;Wa#HCS UIۤtd9St5̱0! %.Z\GCGJЬEI֎%ȂJ^N?ˊ Oͺ=EZitڃy#w>۵64W\CkGʱKH"i7 *.%ӟ5!{Csugw[#FJK;svΟ}+9 >ă$yUT]p)D⮃ah"K*JCaj(Mk`p hX5WNP]wNtx٬XGF5 %yljFuaE,H@Ht@Ƕzǃ`3P py 5G1M8Js#? n ِH[H)<]C4Ξx)/W -X~M?HX u5G%EC.R~xKNW0\ch42i7,v#"@CuE<ͥ9HxX:WaN W5ХzFb@iJ!L&#QdJLaXJpj_z6 ]4$Ǫuچc|Q#bYEdfd+I#4#Ѕ@ǃ!)@<}vz_ y22,@)B9+r)TSSO)#@5#>s@aҪYy8yc҆_$i>4gٶ|,b< tZZ-U[9W\x2 C[<_㼷g}l陎}f-"̼YR_/m%Q_.ߵC˛4\L2||8IŅ1ͰCa&P!2Ꚅyǜ{kagDXi? 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IX߲BM@zeuO^yaq5| iEgY0z- ZҤ0RGս'L3l; 4poIԊ.EHo!^, a뺲"bg3z<-W1}^BL3 BcQ}\f@?rk>7M#͋B0[:p⹳jH~_[rH/* #ò)ccY8 h8%G y蛋ICf!#%K! p$Akð45Mo 58gOsaёh{l1́o;ư$lU%Z͎/;mdSL9ݒ8U$~noT|T*F t"S׫ePIHQrz|%k8g).ozc45 ]1?sJVۦ !;+$|_u'37yaP8@kpobXK8$>N62xSHvV Q?~P?rwH0DX b/q۔)SXr%gqF0~(wwDzW&AzG/.&V{fF6։THGYYd3dT3,LI1­C-Z AZMZ-I'P!Ԋa H5V1f͚Űaâ}*iT[V*_&2oh)!'!ƶhp4F >ͱ\RpijjF/K_W7 v۷oge= J):B'֝ F\f 7RN|3rJ 0&M>j&İьs?>z+VW_}`ꄋ#Ih"t~2EJbH1+gRl5DOGUBMT;vt0 vxN*) "݁a:B& 5R 66#l"d%n馛,C6̪u_W^]0 e7MI&Y[UR6~@vgƕ%:Ԧ~;ܴAnB4zwzO}--Wew>A?㶞TJܻw/ee{3l!Rk3JdzmS`}:7 :ys-*P Å&D<ڂ ~sEE؃N̠NO_M7x ̴>$Ͻ$^x6p=QHoaȐ!Pu_|6o͛Sٖ(6ou=O?/83fTƕSᴑә0r:dngjC ɝ͛Gyy97pCy%;wty8rDN(+c1-ߢƍz;3qdȷ #pFʟGYݙm̝~v$~<Gaem.eenHz)aey~< <j}{LRJB PqnjJk9^#7UR8\sKKR]]ͪ=N?κuH͛#c<?7ԶX\Ck@= 7VR\ű}T*jp{]%'yLӤ*N͌5˗/gÆ gc _kVy/[է["% 5 GilۍeYIJ[gҥG4m[~=s\{@! 32x!^M-pR" r"8 PJ|x78v :E`|3Ӂ6fAJk9/vLiey'9v۷oپh`|)-_|1'BN~V";;L' H<enZKi2_rngɓxz[x 8z( T8͝;&΅\>Dm4ڊ'Ny'a۶m ґ/OIzNFF~_&L| >+ծm@s嗳w^>n*ge; p;rT u{k<[z&RJ(`Κ?wXzO 앢H ;e4TzϏߗo<.''덴#$R4!DiV ƺTO&tdT&P3];dж27n!vZNbh椛;qdhRʐv>l]a$++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES11NYT& &  ֟i!Z֪HZT(Cu[HkT(CZ_֨P kUS֠UUTPZHO֖CԟZB뭮HkT(CZ_֨P kUS֠j ZKZZ֩?]muR ֗B??֠_֠jZJ֯ZԟB?[]ujCZBB?[ZZZj UT_H$ $I DH"B!$D! I H$ $I"DD"!H$HDHDDH$ $I H$HB"DI"DDDD@$I H$HB"DI"DDDD@$&u fI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$$DDI$mlDDD[ml""ImdEl""I$DDm$Hml""$m@H$ $$I%mHmm-m$DDI$mlDDD[ml""ImdEl""I$DDm$Hmm""$m$DDI I$ $DDI-mDDmmI-mHI-m$$m$DDmȋm$DDHmmI$%m$DDImmI""@I$$$I$mImm$mOwbinding site for residue so4 a 1402ac1u1wbinding site for residue so4 a 1403ac21binding site for residue so4 a 1404ac3 1binding site for residue nap a 1401bc6>A 1binding site for residue dtv a 1405bc7;>AV*1wbinding site for residue so4 b 1412ac4u1wbinding site for residue so4 b 1413ac51wbinding site for residue so4 b 1414ac61binding site for residue nap b 1411bc8>A 1wbinding site for residue so4 c 1423ac8=A1wbinding site for residue so4 c 1425bc1=B1binding site for residue nap c 1421bc9~1wbinding site for residue so4 d 1432bc3uu1wbinding site for residue so4 d 1433bc4=A1binding site for residue nap d 1431cc1>f 13O8Q1 + *+UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU uU$GZjEHJ"JTKAuUZUTkTEA$I$BBIIWcWfW#$ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@???c<4c$??tS@ G@ B?@:C?@:C?@:C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4`;PNG  IHDRc IDATxwx3;-YrE+`cwB $% BH^# !P:Z CS+6jmvf̎vU_$k,kʙ3{Ϝd&+{wOcp83>=MI3 [.P *jmOR= aͧGCeI$ vHMM!S__G @n܈POyCafzjpKk/`|]m~(Eqt]C7t Pz!Bq$dΜz f`QG{^,RէO(,L=T֔pY?@('eo.bqk|ŋWIsa?hasa~Qik:NEAQHҸbLQ©xtH l>|v? @hj}]omx]FEAr1ϩ(ޡ^Ȳں#xCmJp70 unS[W]j 87>zEmnJ SQUD^W@(\Wݲ,e/(:;nWc#;E@E!  ._ ,s-k5RQuU bjs%fG4nWjGGNOokV@+Ӱ'K7>j:5M4*,}eF =p81 O=Wλ'`-GNx~X N/‘=W/AOa,3Ss0b&JU0ae7e咑el5-)zw @DS-M=zgӶ7  `-(+ʻ\ւhZGxŖ[af6n}=Ͽc>[4Cc ! j*7 ͟r1.]$]ϼsθ +˝gUet#BY徤w`SM 6jAN>CQW]u#͸dۏu1|H)nP7!1yt ;֢FB ܊IoeIAAe `/N‘g/k}"K'Fs{k5M'Z;ZyLiO3įj_U2P#!j+Yaoc_vt]u e2(,/D74H0"M<;nr#D}̜ O8y9JP0pÜז@o<gLX,;PYSy,>@r"z"nTE=^AeMj_yR Ԋ{WnrΎ)=%;dUkLj!̰ BǭZ$@d$$#g\nʩ>HE3ɀ`M퍮Ty/^_&v $@k^XӾŬmr*Cqy\jٻ}:^*-|h>L4M53ai璞WRY[B0dZO{Sz0?P &bMVd~df#@Xr\pOx}~9}aNC$0?ZJ ݸA5u8;SR=œiJbLTo&PU5|+ΓtLy̛/ʾT֖ٛn=haj_9%{qA'f6y onǀ ؗ#`9ʕsx:,NNI>ͼ*_{+;-x 0LwU#AM^Ws']$8RŞ1HCQ@v۵qV,rDW1 @,c/u@ZՁ5]>I](iLԩpUfFsFh;#O^47Alu:g+Oʈ oh]Jnb~3RIx^IsmC uu|{5֘<>cXL{79uo05$Y&@e} aZ͊]Fzֽ݈ CC&s <о͏͏A Gs$B{$$ b]bsZum#A39Wnhx?+g[?͟>Y&H^XKxkc9咣>b'2,+Z}d?M$ģ!宆fC!M }5j8ҨׯK|kcM;޹HRsٌVoYjd>c{($>Lt@?b^oo|U=T: $I@5旕Kc5ha% 2c?ZL޿S/$Dk p  IN5ZQ] >Xc{qānv!)ݘ2f))ttlkH]Ǽ>`bܾ7>Εkڦv)J,Or@ȇ=v"1h2nWcc<T.W|s_{ϴL I:v !$A Tg\U[j%$ Lި0=XUF HY X+I!+9Ҹ1n3ƭDB^fÖ8 3ƭ5>S(Ek#tq9HȦR$Q^랪6tCo~KG5R]l!*ݒś?剁mV~b1On,TT$ G8Ozq9=fAA-Q dpH4eRj*Y@ xx}rرH$2*ś?5#z} mG'J1ѓTo^ 8~2@ uj!P%I# ɦ,PLm;,MEv )dwzfxGL)cj Mg`S{#Т#2F̜:4Q(0V)s{>w "Z\!,^wY1šeMߞ!(۞C!ȲYQ% :: u5|I.H Tw&ʿ!ΙueWwH1TA2[;o$9Ler5@0\O5J+ӉDB(# n_NU4/5cjJ*|;!q-|FQM^_|p?_4{~R7c87?HͪF\) $Ifβ$6wݝwRp ÉכCV4myD6sTY#H^rMoWN'F">z1Y.0te"{w\]@g;(,ͣL"<F.ͤ`>i^w:bɟd蝛oY1g2:$ɑ|vb|'qF;Do{!C~G W@5HCTTW/j{ǟ {9\s 7l0]r Ԛ+Ƴz0 TooN1_1n%#cov9@54Au ,OlMz N@5u*+|Mdp(|i/cZV,x xf'nW*ZDE3T!@-P,cI1cưl2~_ <\r =+V\q<]gfBm-+WnCBgPSR ;G|}`W*j$ [X#NtQ۰rdk-6v>"j'ҥKNJHc,xiF=0zl,v*B>%[kƨ1D2G?>yc)?@@ӕIZJ7{e+_78N)60~JRQu]ZÄ 5jۘ ۬=Lb./"xaM?}c(s i#ϴM;; DTZJ5xTcA?{-#9Rse_%AfÙ6mg 9Q4 2tpNDS9R}ʃlԹ pCZY7̡Cɉڋ{wG7W[4;7TO7bƭn@;3zS\M Wͻ;uCoRt)xݩ])x=uģ ƩmT9?IeHݐC8BDӘn2KIDATɸ`sx=li-Λo6/硇jG*ٙy?`9JYjld`l<) 2rH1:x (A9yN0._O''Լau3e n|,Κzo~&}Yo^֭cܹ弭5kְj*֬ibX6@r6LJ VM!Ϫ7XtA' BȖ0b$ΜҐ'pv3=ro&_qQL !}bz;Afڵ/_[ ,$ʷkDc,yV!FB5~‘@mA~^ghX1Ȳ= GV@T4*s:Q|xO,[/ŋwΌ\y??ߎs3mq+LX:Ʀ?FZjݤyQGRn!N'.nMP+UH xit* U 7'W Q#At;& 2ο/~B.7[n#t8O~4v,$q>%ujT5, iAf5џR^^FyEe奔&3zLY|ĠIH8ݵeп5E98,*507E*\LO_Ik?'|￈P8'2:j5%ꫨ")No"S,x8E zHH$d|XŹgބ̕2Wrֶdز_Qdt4K _ysq':nl" Qo䮻,E]@j+h\/oRU[J mgjP3 z,$ Z5^ U04ȞHM㐎C(!Oe!m=f5l6=XbEKoȲٳlܘoJ P#av3:s!5(U cr|_" ʤ% !|/‘gM̞^wTח()NoR3(Cv NG^ <(iŷi*N޽{[zySDw]{]~zq轉ꏛ ~t部5l(Z-BkabwmR+Eed#Oeޏ3&j+UPB [{YX2 ۶*)*K\QB2!?#ίkn&(ẕGHTy'smxu,m@O%ϋmX aP'#5ȲNt:=(.A> ד˶W5Ÿ7f@؟Ɗa-`(qsG0צy([($@B{gmj[,5}Ƙagt+)mvCkc)繓/lqĉG$^OC0Mw,妛^bĠ19O!"mh3j$PRY2J3͈i[`_I8\WPT Yv#{%é̂iqz_( kָwAђM*Mk3,ǹ: 1KH#lhN<]14j!=Wkz&$HBlB P`O( vOJ> I.jV`H(Nwl;B#v$Iݭ_ 4D@VZ.ky /VQSFEӎ^q^G^'ϼ]W-32P~oq+I,rXoY6d.XWC#I*quM7J;EqյXSf`a'pٲk3:7'.4=bip"(wtvҍ\S œ$+2f ?( |bʓ8:uڹvͳƶz[F p搝ރ<4<.݄֡@Ї?T?Xif_'%I>MNQ6ƭTd咑Czja 1uUHˈ3xΚL4h e Y1I:IWS曶O X_Ŗo.+Ζe9n7?¾{oV%'*&ZhD>Ik*LKT4 G]BXx=Uܾ[~e[EUkNaf}W`[X`Y= Z8a<7IqtB|JJ]pB< `lkq+Ѕu=qdbO۷P,r G:~&VW⿊<`egR<xiD0POc֯v!ȒԐrlKHȲЩR+}8Aɳ-I @ d~^.JIL1d3 IBJ%Z'_M^K~ەeјՙtaC .!Vbie ,&EY',y d;yxitNJTfmw+1T܄zy9S-9nw*^w j$H0dJ~"ZΚ0G뚄 ABc"F '0y&X JJNk5u;]^\N/nWYR,p8\Fp$d*!]_)mc<ˀJ"՛I7 +V.ʄ!J|Nl4 M|;J&É5Ƀ)VDYmƇTIٳ'i]L7 |2~OdP|y֮ݻ7q_q"nX?,A8v;y߁u߶p[oR~kU9rxXw$NL~~'sIDq<'a$It'sIDq<'a$It'sIDIrIENDB`move=1000;blend=1000;3O8QB1>++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES11NYT& &  ֟i!Z֪HZT(Cu[HkT(CZ_֨P kUS֠UUTPZHO֖CԟZB뭮HkT(CZ_֨P kUS֠j ZKZZ֩?]muR ֗B??֠_֠jZJ֯ZԟB?[]ujCZBB?[ZZZj UT_H$ $I DH"B!$D! I H$ $I"DD"!H$HDHDDH$ $I H$HB"DI"DDDD@$I H$HB"DI"DDDD@$&u fI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$$DDI$mlDDD[ml""ImdEl""I$DDm$Hml""$m@H$ $$I%mHmm-m$DDI$mlDDD[ml""ImdEl""I$DDm$Hmm""$m$DDI I$ $DDI-mDDmmI-mHI-m$$m$DDmȋm$DDHmmI$%m$DDImmI""@I$$$I$mImm$mOwbinding site for residue so4 a 1402ac1u1wbinding site for residue so4 a 1403ac21binding site for residue so4 a 1404ac3 1binding site for residue nap a 1401bc6>A 1binding site for residue dtv a 1405bc7;>AV*1wbinding site for residue so4 b 1412ac4u1wbinding site for residue so4 b 1413ac51wbinding site for residue so4 b 1414ac61binding site for residue nap b 1411bc8>A 1wbinding site for residue so4 c 1423ac8=A1wbinding site for residue so4 c 1425bc1=B1binding site for residue nap c 1421bc9~1wbinding site for residue so4 d 1432bc3uu1wbinding site for residue so4 d 1433bc4=A1binding site for residue nap d 1431cc1>f 13O8QA + UUUUUU_꪿UUUUU_UUUW*+UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP uU$GZjJQR"QD'IRTREJuuUQKAuUZUTkTEA$I$BBIIW WfW#9? ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@???WW$??@?@C?@C?@C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5/PNG  IHDRc IDATxwT̙-²ԥ(H,`5j5bjx5W_rM1-(]P(RP"m;)3}gg Ӟ||- A iI<=H=A!OFyz4zӃC$ iI<=H=A!OFyz4zӃC$ iI<=H=A!OFyz4zӃC$ iI<=H=A!Oh+"+ IHHȒ4-ʞuu@Sg8`E$~YFFr%K2BӣuG&OA$IFdt]C74 CG @l%dƭxC%O܁\nt]0ttCPui,dJ"ˍV^̎-ɓ߫EUt]Eգ*|L.,uP\n$IRnG/u6Xծ{fsp.T5@ U ѵh٫i=:Rѭ~B aTזuH0Pe#J?J$BѭFNE<2 Y:%MWuۀ[??5]:Bmf{%@Ůk'͛ Ȓvݫ`0Haaazwd [˃$I#!FVfzBMIGFz뭬[ypxNI;BRGF (*Ƅ Bڔn̘1L0cQ }UwF<.$I\h[y [P M[f%7o0%r{O߾} ~;mlN3Wݭp+h}d.-'|mx=~ 7#%}>ă>]Wn]dXjcms9?NݎLt#yK"kp+ k |[ٲgau^}JíxرwCwq9qQXXE]6?BF.\-}2p@((()SpWUt%.deW_W_9Ϝ9q1tPn>Ԇ}4ll({w@ _Fϛ7x?O׿u9Rq.6,[e˖?)(_Z3k3rH.&/Y%Klv6WUW78~7RRRByy9555TVVRRR'L;jMg͸E $y]JQHH w4a_َV#==6oRf$9>M駟n8Xq۝}fW_mpn-A8ܪ:s  K.\5 O0Tso¹%@*dMygXl\|1:d8 ]4;osje]oZ]ܾm۶`6vY~>ct̚r QSWIT ja\2 2OIㆅ%Ewu1y+ Զ)?,_.C\Z8 ^vezMy97,\ذ6b4m W.3 ?[iϣ.\M(\K8D$$ʫu+yyӹa /@  q@`^hS: ,H9(*2'/O>I&1vXLnnCn^-rIkh,g[$7͸}GBF 0 a‘:4=! v6Y2hU5O^vr52U?EO3{(zV0bL0t^/2裏Z<&KVMF 'Ib&ze KɴТCU/*==%hʬ)?BBvV$'^7 wedFm-͚5nVaWq% 9{̨9dff>aԩSYr%`l:M)?aFèZj0L3|(BSxMIg A wؽ;uP>ϡݍPdIn81jGHHx<<7n| H9 |g'6<=.~̙flڴo\gj N=Rs4 Ϯ UԦ8`/Q ՁZk@ PymT!Ղs8pm<(.7.\e3DjwW>$Id^7o@W7<S77q%Ѧ{=dzȃA`Ųv?Tuܥx~_'2Mah! 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BAҹw~ְ%{dכp\+86 '[=pk1ES2nmW_/~` B $*k6n_цV[ܳ)UYVg~X.#+d@mQaE Ƒ&QOY.݋kCnG"d3^]?3m4͛\+l4$]vmas1$ICY}[6ay snj!\*4v#|Iu{dphB HU5a5ι]0lf;bOm5s $I")++cdee͠A0 o=S1'1Ә8r v{,NƏIY^R(mE*Z~=(Lb:a8/6#6[Ğ9W=ؒ0m5!td@:(0T-bG)5=V&/@5 um >8t iL:%!2!ShZ9;زJ,˸nzV0t\!Iؾc+ 4^xlz!n^}*L0|n5i\.w[l{ќy晔DQ LIf4_&pk^xU7Sx;?hV&7') -7D8LYgvShQ#r[oO%kXf \s `/^d /Yf$#!7o7]ojݍ7$%￟hu F lwr,CC`~3ϛ6?׷ku72Zqp\8)ylͻ6+-iYyVP 7[9[neݗۑp+\.*ㆎ5kb" ^O7wy Q )*C0c扬\@]%,9fU3 _2qDyB]vs6?f$h^"n\DfS@߾nNy‘2ouMWY#uɶҵli+,]v{Q\s c5^wjCW 4MmR{MGoFyy9%%%XEE7PۇM{fNݻy뭷8p@ϥjQ*3fK5Z$Oq܁}Ǹ>䰣t=FX "K.XLBӣ ɿd-xXa$sw=먮-cBZLΛu+E}G(\"mlذ@ %K{<(ʣ <ټӦ~?/ᅾT ڼ a8E?z*-43Ff-)?wq^1uFyv 8CVï}#!V| 7@(RG(`ASiSpŹSR 8"Zv7_gMjQ{զC mehSSWAu]eUl-YM߼`{ @4tw@Figʲ1$ƣp'a!?.fUvO!PaUIInE&fHm/}.?~\," |b~OV;EĢW."^09[BU0`%*j &bkI,}md+l2#P`~a>o:zd^߻3mH2G7Ges2| wGwFMtwbw#@< @JɱYbgcVL" 5P5i 8GͲ9V:cu(.7>}j`Z,IeU eCъ z)N.믧۷'ʷ.O>iЖE&9Sc[ |ƅl!Ig6t9U۶F)M fjEOZ7>M< W}7 +Dբ,]lMS8$ew\QmKy`WXy$aXx[6IꪐBv6Nj/#<”)S8䓛<RkT-$IN(]<njI :\–G/0$|\ ,8Qb,Yc ]dumRdO!G<9=I8&,?[ڽSڙ6m.xC#/7zXl{e= ˊzU5XԆ߫?h$rrl]ަg!X|6RRUeY7ܥKc5ظ9$IuDzٱwMy;ewdDzl;H.i"RNC Cӊnw%/[bnѪu58gk&l-RAΘx_DÊ3rd\bGqfSk7g3אhׇ{=:2΄}vw`+Oh($mh}O׾U>U>B;bGz܊L`'lY{$ĩ!~ҥf4d7&G R^=ht}",5xmܱ".II9f8N;3eqlݺ!1qZ|91{, I֑Ǟ,mw@~6&Ќp9Gpl'Q',7ؖd3H<!۷2nv~-pەWbA\kE$ɌNinHʇwpI}ԉLsoG{8X9Z{V -1_+crgk./^p|\y\Ks#!Qn1Ӝ,C*$2 t# s5:'$)$g0G$Dn&IDAT͆-(vg:xz6$ 0f&1h3Qťwp׎E|{c¨Y OYDzZvr &S⛷,))NYdJMvv몵. GT c:^oC]jw yӯf*;&I|DM]EJ28p!DP^JO[;]Rvbs zyeѿ0QҼS< CsJK y.V'h!ˮ̓ 0kQ7,=ҭg2|JmaρdՋ,[G;~ ޷q'N?'e)'8`g%CDDHy~at5)m3rd@}c7ųeYJ2}dsPg; hCD}2a?rSc&+#&4EFB<[ĞߣjaF><*Z^߲CN~5 =5#) v|)n銳) Lq lyfg{Vp۶#Q6l2%;=KMmt,d[ı< Չ54Cs.#uԆ)*Ŧ+ؾ}6NUDNJCq)IL:R30w ]7I"PW?ogʳ+< 2%M7jJ0TC0 Dՠ9CYTT=Cͱp'e3aϿsoqg{ m^Ȳ \|:`$I YdejZaE9qai~ѣjP3,R71M75><'"(Z:LnH74zJMJ2xuyws8Jq8RGvF% $qIxݎ}H74T=j~J8ZG$Z8w(yx6y8l Ff\+Rx vy;ȓ5y±VyדG`INV4cQSmiA{`ΉW @#E|JH?kpݸ'#I{E PW﷫O] ۠/ o0*J]NY&S\a=tjq_ef;|,3|D0[JV!K29}Wr v#OI8IG`8x:FpɯTe&0䫮| `/֟wx L'4C 3RǍ1k*bÛN"mqTςl'C]׉Ä#"0H[ W!2ҲӜ?YVߗFGd !B^/XG[ҹ0i\ۍ[qvvd/€H4_lTiY~_&^eYeIAQYMnzŞu/Y ܊'^nڊ}N HYA&-һrگh=Yl8'ao9T!$Gx<79ٗ,rmϛnNEg IOD$A&,bBu *Kν\(|V'#L!͓A~N!}r0vgQo/l/m8 ^ ߕ|8=GHgı1bб}D܁<1jj* ~apG*Ex'#HΧ,Lܔ4 D">]k3'_@ YCtgYIqNvmz%?ӟKD 2|DҼH߼A~Gr:М+ EԐ>Jab4-1#f`/0 PhKh#y.}H3cۃmi#I$EY]oU# ͦfT'͛A^v $=- ^ke N7sS^U-LTi+ͿI$d+AkMh5y.}$㮌UURvҜ~|s4٭H$NIH4aS٣HHvi~ۚ<$j@qQo5|Yg1u^if"SN>BrE~1RR I=@nތk sʾe Hal \d[NDhmg[yrf' &Ês GCDfׅ$BF2Bw Yw6͎#5ɢQsq׫CхF4b5q$svU@ !VDCS} 8h9T(_u1h~t>=򐙝E$2!KjUS(EXL.,KhNC1$H9S";7nf XT;ϾTej6HNh#s64jjGFZ/ideg^dek3\d[L=39#du]Q5@j|x,8b .:i$d@`_ē`E 5uI,aa!퀙YJ:G9U84D] j/}rHeV<8" X!.̏kRY¶cYTH8 R-Eaj4^s0`C܁#A++ uU$GZj#h?Zj֨?H$ $B!BBI I?Z UtcB, f" DDB%UU@j !""I%UUTDHEUU UT""I$DDIUUURI*UC 2""$0$I$ I$""%UP*IP UI$$"A*U$DDA$T""EI$DDIUUUHUC 0ȈaI$AI$ 01I$TB J TJ ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES11NYT& &  ֟i!Z֪HZT(Cu[HkT(CZ_֨P kUS֠UUTPZHO֖CԟZB뭮HkT(CZ_֨P kUS֠j ZKZZ֩?]muR ֗B??֠_֠jZJ֯ZԟB?[]ujCZBB?[ZZZj UT_H$ $I DH"B!$D! I H$ $I"DD"!H$HDHDDH$ $I H$HB"DI"DDDD@$I H$HB"DI"DDDD@$&u fI$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$$DDI$mlDDD[ml""ImdEl""I$DDm$Hml""$m@H$ $$I%mHmm-m$DDI$mlDDD[ml""ImdEl""I$DDm$Hmm""$m$DDI I$ $DDI-mDDmmI-mHI-m$$m$DDmȋm$DDHmmI$%m$DDImmI""@I$$$I$mImm$mOwbinding site for residue so4 a 1402ac1u1wbinding site for residue so4 a 1403ac21binding site for residue so4 a 1404ac3 1binding site for residue nap a 1401bc6>A 1binding site for residue dtv a 1405bc7;>AV*1wbinding site for residue so4 b 1412ac4u1wbinding site for residue so4 b 1413ac51wbinding site for residue so4 b 1414ac61binding site for residue nap b 1411bc8>A 1wbinding site for residue so4 c 1423ac8=A1wbinding site for residue so4 c 1425bc1=B1binding site for residue nap c 1421bc9~1wbinding site for residue so4 d 1432bc3uu1wbinding site for residue so4 d 1433bc4=A1binding site for residue nap d 1431cc1>f 13O8Q> + UUUUUUUUUUUUUUUUUU+UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ uU$GZj#h?*JQRUR"R($ $I"BHOWWUWfW#OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT ubinding site for residue na a 279ac11vbinding site for residue so4 a 280ac2=A1vbinding site for residue so4 a 281ac3>B1vbinding site for residue so4 a 282ac41sbinding site for residue na b 2ac6GI1vbinding site for residue so4 b 279ac7?C1glu->pca pyroglutamic acid MOD_RES1?333333?333333?333333???????@???0K; ?shikimate 5-dehydrogenase i alpha; chain: a; ec: 1.1.1.25; engineered: yes; mol_id: 2; molecule: shikimate 5-dehydrogenase i alpha; chain: b; ec: 1.1.1.25; engineered: yes; mutation: yes3O8Q3o8q P 21 21 21Bc{B|C׍???ab??? AAMHHHHMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW+aaf , ffffffctft , fffffff fff, fff fffff ffffffff ffffff ff ffff ffffffffff  fffffffff ffffccfff tbbff fffffBff , fffffff Uff Bfff ,fffff ffffffff ffffff fBf , fUffff , ffffffffffff , fffffffBBff, fBfff={maana'aaso4saaso42s]qAaaso43s header aaepe1Xepe.4-(2-hydroxyethyl)-1-piperazine ethanesulfonibbna'bbso4stA0+awaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193bwb194bwb195bwb196bwb197bwb198bwb199bwb200bwb201bwb202bwb203bwb204bwb205bwb206bwb207bwb208bwb209bwb210bwb211bwb212bwb213bwb214bwb215bwb216bwb217bwb218bwb219bwb220bwb221bwb222bwb223bwb224bwb225bwb226bwb227bwb228bwb229bwb230bwb231bwb232bwb233bwb234bwb235bwb236bwb237bwb238bwb239bwb240bwb241bwb242bwb243bwb244bwb245bwb246bwb247bwb248bwb249bwb250bwb251bwb252bwb253bwb254bwb255bwb256bwb257bwb258bwb259bwb260bwb261bwb262bwb263bwb264bwb265bwb266bwb267bwb268 _ile  Basp     Bgln$  "" !# _tyr #"$&.#%$#'&()'*'+(,),*+-,/  Eala $/.023/10/4  Eval04357:46548977;  Ephe 5;:<>E;=<;?>@A?B?C@DADBCF  _gly<FEGIFHGJ  _asnGJIKMQJLKJNMOPNNR _proKRWQSUXRTSRVUWQVY _ileSYXZ\`aY[ZY]^\_\]c _asn ZbZc`dhaeipbfpcgdebjckhlnimojkjkq _his deqprtzqsrqutvwuxuyvywx{ _ser r{z|~{}|{~ _lys | Hser  Hpro Hphe  Hile Hhis  Hthr Hleu Hphe  Hala  Harg, Hgln  Hthr  _gln$    ! _gln        " _ser    # Bmet !#'( "! $#%$&%*$ _ile !)!*'+/(,07)-7*.+,)13*24/506/0128% _tyr +,879;C8:98<;=><?<@=A>A?@BAD& Ethr9DCEGJDFEDHIGGK' Eala EKJLNOKMLKP( Egln LPOQSXPRQPTSUTVWUUY) _cyss QYXZ\^Y[ZY]\ _* _valZ_^`be_a`_cdbbf+ _pro`fkegilfhgfjikejm, _valgmlnpsmonmqrppt- _aspntsuw{tvutxwyzxx|. _glyu|{}|~}/ Hphe }0 Hthr1 Hglu 2 Hala 3 Hala 4 Hlys 5 Hhis 6 Hphe 7 Hphe 8 Hala 9 _gln : _gly; Bgly < _arg,= Egly > Ecys ? Easn    @ Eval      A _thr B _val!"'' #%$&!"!"(C _pro(-')+.(*)(,+-',/D _phe )/.029/10/32453637485867:E Hlys 0:9;=B:<;:>=?>@?A@CF Hglu ;CBDFKCEDCGFHGIJHHLG Hglu DLKMOTLNMLPOQPRSQQUH Hala MUTVXYUWVUZI Htyr VZY[]eZ\[Z^]_`^a^b_c`cabdcfJ Harg [fegipfhgfjikjlkmlnommqK Hphe gqprt{qsrqutvwuxuyvzwzxy|L _ala r|{}|~}|M _asp}N Earg,O EleuP _thrQ Hglu R Harg S Hala T Harg U HleuV Hala W _glyX _ala Y _valZ _asn[ Ethr\ Eleu] Elys          ^ Elys _ _leu ` _asp !#' "! $#%&$$(a _asp!(')+/(*)(,+-.,,0b _gly)0/130214c _glu 14357<46548798:;99=d Eile5=<>@D=?>=AB@C@AEe Eleu>EDFHLEGFEIHJKIIMf EglyFMLNPMONQg EaspNQPRTXQSRQUTVWUUYh _asnRYXZ\`Y[ZY]\^_]]ai _thrZa`bdgacbaefddhj Haspbhgikohjihlkmnllpk Hglyipoqsprqtl Hglu qtsuw|tvutxwyxz{yy}m Hglyu}|~}~n Hleu~o Hvalp Hgln q Haspr Hleus Hleut Hala u _gln v _gln w _valx _leuy _leuz _lys { _gly| _ala } Ethr~ Eile Eleu Eleu          Eile  _gly _ala  ! _gly! "$!#"% Hgly"%$&(%'&) Hala &)(*,-)+*). Hala *.-/12.0/.3 Harg /3246=3543768798:9;<::> Hgly4>=?A>@?B Hval?BACEHBDCBFGEEI HleuCIHJLPIKJIMLNOMMQ Hlys JQPRTYQSRQUTVUWVXWZ HproRZ_Y[]`Z\[Z^]_Y^a Hleu[a`bdhacbaedfgeei Hleubihjlpikjimlnommq Gaspjqprtxqsrqutvwuuy Ggln ryxz|y{zy}|~}~~ _gln z _pro _ala  Eser  Eile Ethr Eval Ethr Easn _arg  _thr Hphe  Hala  Hlys  Hala  Hglu  Hgln  Hleu           Hala  Hglu ! " Hleu"!#%)"$#"&%'(&&* _val#*)+-0*,+*./--1 Gala +1024513216 Gala 26579:6876; Gtyr 7;:<>F;=<;?>@A?B?C@DADBCEDG _gly<GFHJGIHK _glu HKJLNSKMLKONPOQRPPT EvalLTSUWZTVUTXYWW[ Elys U[Z\^c[]\[_^`_a`bad Eala \dceghdfedi Egln eihjlqikjimlnmopnnr Eala jrqsuvrtsrw Gphe swvxzwyxw{z|}{~{|}~ Gglu x Ggln  _leu _lys  _gln  _ser  Btyr  _asp Eval Eile Eile Easn _ser  _thr _ser  _ala  _ser  _leu        _pro      _ala  _ile ! _asp! "$(!#"!%$&'%%) Gpro").(*,/)+*)-,.(-0 Gval*0/136021045337 Gile1768:>7987;<:=:;? Bphe 8?>@BI?A@?CBDECFCGDHEHFGJ _ser @JIKMOJLKJNMP _ser KPOQSUPRQPTSV _arg QVUWY`VXWVZY[Z\[]\^_]]a _ser Wa`bdfacbaedg Evalbgfhjmngihgkljjp Ecys hohpmqunrvyosyptqrowpxuvz Etyr qrzy{}z|{z~}~~ Basp{ _met _met _tyr  _gly _lys  _gly _tyr  _thr Hval Hphe  Hasn Hgln  Htrp  Hala  Harg           Hgln  _his !  " _gly "!#%&"$#( _cys #'#(%)-&*.1'+1(,)*'/(0-.2 _ala )*2135624327 Egln 3768:?7987;:<;=><<@ Eala 8@?ACD@BA@E EileAEDFHLEGFEIJHKHIM _aspFMLNPTMONMQPRSQQU _glyNUTVXUWVY HleuVYXZ\`Y[ZY]\^_]]a HglyZa`bdacbe Hmetbedfhlegfeihjikjm Hleufmlnptmonmqprsqqu Hvalnutvx{uwvuyzxx| Hgly v|{}|~} Hgln$}} Hala  Hala  Hglu  Hser  Hphe  Hmet Hleu Htrp  Harg  _gly _leu _arg  _pro _gly Hthr  Hlys$             Hgln   " !#  Hile#"$&*#%$#'(&)&'+  Hleu$+*,.2+-,+/.01//3  Harg ,3246=>3543768798:9;<::@  Hglu$4?4@=AE>BFO?CO@DAB?G@HEIFJGKMHLNIJIJP HleuABPOQSWPRQPTSUVTTX Harg QXWY[bXZYX\[]\^]_^`a__c Hlys Ycbdfkcedcgfhgihjil Hasndlkmoslnmlpoqrppt Hleumtsuw{tvutxwyzxx| _glu u|{}|~}| _gly} _ala  _leu  _pca _ile Easp Egln  Etyr   Eala   Eval  Ephe   Egly  _asn _pro _ile _asn            _his              _ser               _lys$           '   '         !  "  # $ ! % " & # $ ( Hser   ( ' ) + - ( * ) ( , + . Hpro ) . 3 - / 1 4 . 0 / . 2 1 3 - 2 5 Hphe  / 5 4 6 8 ? 5 7 6 5 9 8 : ; 9 < 9 = : > ; > < = @ Hile 6 @ ? A C G @ B A @ D E C F C D H Hhis  A H G I K Q H J I H L K M N L O L P M P N O R Hthr I R Q S U X R T S R V W U U Y Hleu S Y X Z \ ` Y [ Z Y ] \ ^ _ ] ] a Hphe  Z a ` b d k a c b a e d f g e h e i f j g j h i l Hala b l k m o p q l n m l s Harg, m r m s p t x q u y r v s w t u r z s { x | y } z ~ {  | } ~    Hgln  t u   Hthr   _gln   ! _gln   " _ser  # Emet  $ Eile  % Etyr   & Ethr  ' Eala  ( Egln$  ) Ecyss ] * _val  + _pro  , _val     - _asp             . _gly     / Hphe                         0 Hthr      !        "1 Hglu   " ! # % * " $ # " & % ' & ( ) ' ' +2 Hala # + * , . / + - , + 03 Hala , 0 / 1 3 4 5 0 2 1 0 74 Hlys$ 1 6 1 7 4 8 < 5 9 = F 6 : F 7 ; 8 9 6 > 7 ? < @ = A > B ? C @ D A E B C G5 Hhis  8 9 G F H J P G I H G K J L M K N K O L O M N Q6 Hphe  H Q P R T [ Q S R Q U T V W U X U Y V Z W Z X Y \7 Hphe  R \ [ ] _ f \ ^ ] \ ` _ a b ` c ` d a e b e c d g8 Hala ] g f h j k g i h g l9 _gln  h l k m o t l n m l p o q p r s q q u: _gly m u t v x u w v y; _gly v y x z | y { z }< _arg  z } | ~ }  ~ }  = Egly ~  > Ecys  ? Easn  @ Eval  A _thr  B _val  C _pro  D _phe   E Hlys   F Hglu   G Hglu   H Hala  I Htyr   J Harg          K Hphe              L _ala           M _asp                 N Earg      ! (    " ! # " $ # % $ & ' % % )O Eleu  ) ( * , 0 ) + * ) - , . / - - 1P _thr * 1 0 2 4 7 8 1 3 2 1 5 6 4 4 :Q Hglu$ 2 9 2 : 7 ; ? 8 < @ I 9 = I : > ; < 9 A : B ? 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a a a a a a 1 1 1 1 1 1 1 1 1 1 1 1 1 a a a a a a 2 2 2 2 2 2 2 2 2 2 2 2 a a a a 3 3 3 3 3 3 3 3 3 a a 4 4 4 4 4 4 4 4 a a a a a a a a 5 5 5 5 5 5 5 5 5 5 5 5 5 b b b b b 6 6 6 6 6 6 6 6 6 6 6 6 6 b b b b b b 7 7 7 7 7 7 7 7 7 7 7 7 7 8 8 8 b b b b b 9 9 9 b b b b b b 10 10 10 b b b b b b b b b 11 11 11 11 11 11 11 11 11 11 b b b 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 13 13 13 13 13 13 13 13 13 13 13 13 13 13 c c c c c c c 14 14 14 14 14 14 14 14 14 14 14 14 14 14 c c c c c c c 15 15 15 15 15 15 15 15 15 15 15 15 c c c c 16 16 16 16 16 16 16 16 16 c c 17 17 17 17 17 17 17 17 c c c c c c c c 18 18 18 18 18 18 18 18 18 18 18 18 18 d d d d d 19 19 19 19 19 19 19 19 19 19 19 19 19 d d d d d d 20 20 20 20 20 20 20 20 20 20 20 20 21 21 21 21 d d d d d 22 22 22 d d d d 23 23 23 23 23 d d d d 24 24 24 24 24 24 24 24 24 24 d d d 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 26 26 26 26 26 26 26 26 26 26 26 26 26 260K; ?shikimate 5-dehydrogenase i alpha; chain: a; ec: 1.1.1.25; engineered: yes; mol_id: 2; molecule: shikimate 5-dehydrogenase i alpha; chain: b; ec: 1.1.1.25; engineered: yes; mutation: yes3O8QB13o8q P 21 21 21Bc{B|C׍???ab??? 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