0k3.6-1h/data/swissprot/ 3P52.pdbdupa 1XNG.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Nh3-Dependent Nad Synthetase From Campylobacter Jejuni Subsp. Jejuni Nctc 11168 In Complex With The Nitrate Ion[/h3] [p]E.V.Filippova, Z.Wawrzak, O.Onopriyenko, T.Skarina, A.Edwards, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3P52" target="blank"]3P52[/a] [small](deposited on 07-OCT-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1XNG.pdb3P52 a_3P52B1  1XNG3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13P52B1):,9<@,91 C?BGCC??H@HC!!?!  ??BBGC?CCC!!#!!HH@H?<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???|_W|$??@^ >@@9$F@"8?????@@@x@x@ ???333333?333333???#~j????333333? 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?\]kbŌlll?sf11/hũ-N>4&O=|8 Cܮm>>EhZ&͹)(kٰcccJu 1[1z6o70aB.5 В9H$M]^Dͭ#q N6pa wOde̙ٶm-_|a8MKMeȑ&u*J㽸ՒW6˥Е۲tM#77x33rhjmdfu:d8pJu:]>#G5jԁм77]^|sQymmqsr3).tH$9LDτ QE z#Ux60d2^9tLڮ4TQt$E-!-SxRY0=|}1m_Vu#}ǎRPFW4oClj⋝u\7> ɘ1Ӑt:2e V)KՋO?MZ͙+W8R1(:;w{++痛wYh᱔ԒcP{}v];/m`(KsQrIMZ}} tۭR~}/>>h17'FG6lPUfGNN:w' *ޝ8u8r%jvȹs=W!`_yA8uùRTP)\PD$e0,E^^?:u~,mb?}X- ѿ瀀}$K0ɫ[s``/PmY EFO>EpSks}Tn}|DLbe.zDwwtE[,+VL~hL νЮ]e >]'*3frѳq2/j[#D߾EPPj{gD SAA&e'EiN[II ʤuX0v3_SRRh__Q:+E֛< u;ԭAhKC!2YSڵǾ}%;e^^AE7 l B\ !!ڪMa7nTWiիLltZ۱Νqdffp&w7C~/^~}.^,ҕJdXYLASǢׯA3ը$4jDbB= ЩTLswW]Xd'FݷJ Ϸ~pgkXα:`uρ /Pmw?xTJ\nř3 in]01K>dI]wQ(bHL܇"/o*:lmp_"#uzN2O;;N}TOH_o{ IͷEڋbʔ&Fx79;%=;8|%||V Unse"<#||6"1B|bfddQ޵99YRx1k޼hժKuEquѱpt,! oˬ6|X?˼ #G!!bo=S%:6d?t'm|J5J<""~5N!p#k|*k֭ʻlXZv:DFCVaݼ9y$BJ("cm=>yuE R'Wqw#9ePr助7T?X[;s뗯o%- 3 fz:RSPP@l@XbT"GYjXaeub'm22ΛKV=kU̮XI$ZYHZ͙;whW ݪW&OMnAܼiYCJY&.|w&~~XI$trr{зꞞT?:GN- ;3"&!+:,HOgbss7oJ !7͏@:xxL"7w7vv֠T2$??ckG˖66E U)hAfWP*K$Hķ&  ΡTF2&Mߠ[t=aaPPeBr6mL۵3g)tW9;8ի(JIx3~6IDAT_xޟT!C6yWDǎKE!QQ HѾnu˖"Y3Ѭqc1Ii={ZavHX'tdfY֐m`vqIffTv0={f+g| Iz5DrMJv-Dm7,Z:nT-`MAJamݩT:Gufʾ*)CCEnnݦI/ٝ;&i@G{~ +\l~@eiER߈?P-Բ83EVGui@1{y[df~88u;22LU>&`Ӧ4k6?ٹ6HR$r5WeÆQu2 8w~|G<߸?1K~Z|S|p!O=e͟8\]׿UmGҍnqqM<<&`oߚgaQQxxz~PۺmMN?KX;viztN͛i\&,6˖}z!/HhTaڪe۷Kp*R^-&o4jCTK܍ś.3*z`jG8;wnAFHR Z &oQղrq,K7_Q9$dpq^^}GP~"?;.+WT,ܸqwB"(h`%,L,|ݿE ZS2̽de%%;ܼ#Ǐ" @ϸq[; q,ʕ GJ_Q"tF<۴1akʸy3ZP f?Vp XYفJdB Fɍ'7z|9v{nߚ-YƮ+Nyqilm]{/p-%QpmA?{{Zg׮V[ЌLTDMPbju6A'&)i'͚M)\nVKp 0wW9-Z رH,o呕Y.cbxwo&SmT7HHXEF.RR6ebUS @rN""-+sU)-]ŠT駿bW8uj- 9p`-;Kg(=wDVJ? }RzETFy,Z$FG=^2ʏ[K>[n!!KcLJ%CrrXe Z@^9Ξ}դ뷱)in-k2^#Y O.O=՟3 :6ΝTƆ}jiiZ/a=3S'\Q>`ٳ~ɪwx^2~iO{ !/AYŘ\X[ەg1ddQv6mҽib;"#}3܌gYW|D*VtC-WWHK# T*F~;dWn7o/.ݺ>x“ug_C]-6>&+sQAbgD?Cǎs됝GJ+s B !!ٻ8Plogk#GCZM^~>ǎ-ܧ v?ɛ7y: 8wȩSJhwRgzx NÅ ?ce偛'LDT~=ae % iH2ؽ4BX9b>}7nHW[[6ǜgϟ'SdhVxۣjPxUXDxU[Ri믧Rh >}}۲uEeQ$&f Rzs6w1#Gǚ {&+#w_z9K /0N};w /¼<~ڿspt4>{z- NW|FҥHM=[rO(n>Pbآ:ubî]Fy+V|…_׿޽噁аaC$ ;Gn"&}}jI];̥K{^~=M6*8[HNFVdeg%D²͖p("ۼoDDT]lLWNi0CdSX. k_kbѢ{b֬⠷ww+W=c˜1űcয়6)[t͚J<$&F MM }4ߛ{xX| ^dFEx4i2Tn6 ҷv#; Zf})07\Ȋ+k#{"#F̂깻h4z~Zg|Grh{qid2ڎٹddg#J9`|:)24Ujƣv|?23O`gGs P*iiWU+7 ![5n=hr}ҥiiXâN^$;;(0`N[Ot)K,b BSLNVj*8V\kkkZh+;=hըq -͛+fgGF~~9Edb2 ||;ԧAgʓ,O-kР+(znR.Mĕ+'~*sc2/E#F f2^i%a9wNƍS} v>̞'8{_;͛?)v's9)5%6nQE-Mާ}ql9^Kzz:IIgHMV[鯿ֳ'M}F&x fǼe+qF3gK.]槟Q4mچgA*-?X$%iCLHj5*mj*kΞ߇ ޽J!*jju !׮؅ ZЁzqE-[S;Ҝ932Mr9p`/'sixǟ(zK,rR7m2Ks4jB1rJo$/2mtϘ:-},)  C9{1:\]8Kuݘ1_\<Ӗ9(df2h4lm|z~E%RieS1qa,l$:ž8;WaHA׮IH HVPGpr>|j`g瀵!Vϼy/Xgo0hH r9 ++lx՝ZH 99̛7L݇RC~~.z_EQ̍Wԛ +It:>sT@)8zᤩuÆboY`JÉ{8yr/ＳDJMZ&{g?L-p/;ߡKxhy]lذd&L ...ॗGV>b/|T!<׮J_ 0[UbݏV`96={r[%X||P)44\[JСFs_y`fȢ%11'= Fy=>nܹ^3l}wo"|}w[7z3>g<^i,+:dSM+Sx81u|81Dye24 24 P $Z7kF=??l\*]+66lNN.ߎƿ|1*PIENDB`move=1000;blend=1000;3P52KK 9  j_j_WR֯j_ԿZ///jZjZAK/j_<o 6(JpS~_8d]mrڲZZ5ӫQfu8c̯yk'9j_=| iA6e1oVS#^έw8Cn F r=t֭t|,@jCX͞)XYzsXaपb4R#~,\)de+20`pS<^+犰ͩ[٢%nV{kH( "CjPΩV*2[$wƽuËkToIpP{V5fiH<,AVlq2(PsSlPuhh&lEtՐTHhT 6 QR'04|yQ!Č-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???3+$=?@ 8@9$G@R(<?y?y?y??@@@x@x@ ???333333?333333???#~j????333333? 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'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???û$=?+<L@$@?>8?>8?@??@@@x@x@ ???333333?333333???#~j????333333? 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b=8O:8v(|zKWw)7znA,"UOK=7^K_rpwg#O h Am b̴8p# dv-~iH_ _ԪXyH֏? y q&J{%>^L,Zhw]C4q8 Bj)q)pSE$'(w_Aƙjd)5v[xՆ^@oO1(nl482:wәu5xkNZ6*4kPYN.A👄]8ߛ: 'k͘_igXT|qm,j8$DWf%T[c}DBT@ȏ ܉#g_4iiu5Sa_|YeY^Q([٧ L }{f%Ѫ#I-5}6'1FY 䣩A@;ErFWTkvmGOKl[j1жz jkCp?GV50d$yi=I ?g7=KTRZƸ~F9q^9Ogj^i%By%diòYegTކ<#2cEE]g߂,RHzyuB,T>0m3c 9 =t~32Y=շ~ tٝHJң$:6#&ֆ_,W|+axw>`<"lc>v5fЌ=g$&7cr[[ڼs1n5*ԁ:~TDA?@ E="LY¸&fjF&On⹗0w~-HQGGi P'wѹ0| \nOE'P¸wLK <'B-αq:8j DHO@ "ξ?t{͛S$ ä|0H`+hinaJXUOWiE d5>t?B25dm6jjKkdyhܙ7Gϯ_|?* NMט~ϻp==nxT9zG#J г%}SKE{DA\VZ^A\)KPZE|UXMV!L1j`ðh*Qk _z(la<f -h6kDq܂Fa[8 56{@OiM4֌-S(QAC[g ^قc lAxB<[d?IENDB`move=1000;blend=1000;3P52$KK9  -  ȑHϪN=Q,.s YH6o}LGT T`l<DDe(? ,5A!6Qb,l8SXe%aRXQ"QH XN@5'?ϳ},bŌ )ͶI_5 \*Uv@ܣ뗠9/IF@ ]/Aemakvے/%okeAm_gdGlxVXi6M(PL&l0d͖,Y2d&!l 8"&ihSz_tq=װK_{j(pHK **  $$$8]"q=2 h°Q68+Ny_dI${]LU˘^ｅ|ڹtby'4HK%]R3+eUUU­pE,WH#|^-Q#׮u*Q'+‡ a¥B!Wa 5 !J぀Pr1fc؞\|M h Uܹv8 nʧ}PIuȷ0 `diA͡B:f6i,!AhVWSٝeyk#k0\40a @$ JTQ4㋷\„La @` .@jD ^ ]<,(r^vcqٱ _<.;}܂{[^a\*mzǖ'o-T et+mV]uy[熵hT0 ѭ 2r-A6@LaHChѓ4m4t&EJ׎Uxk쮷PxkVDMRmml3UgU箻okVmYuaegu\Fj*yYvEuWO([L͓')cC LdRjшh$(M2Lf LTL`f2BY3#f26L1@eR9@b c*CLYrƓ&Llr.j#ZiFCEFrZM2v%2J+{4 *P>H"D&Ӫ}d=;4Fbś6o}: c(LR>.\E8"99L؜D>ꓘ?~a?r+Eˉ/( _fzqǘNO )b͊ĆUϪ>|ru,V,#ȑlVH$A( AA@PPViiiiiiiiiiiiiiii< 6 44i|]ltxrC NQ6V,Bt2GJN MM@FQ2N raC"j MIȖ:RN+((++\,R*&xa R1\drh&'6$T0$gsU,ZaQQB5`asu#CH(fc&qhH"4 BfcH!`TDt`^`/& 6mmmmmmmm-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11XNGii| kOZjMi_!RP֭ikOZjMi_!RP֭i $"D"""$I"DD"A$IDH"B! H$B"""H$$HB!H$I$D!"  fUUUUU$J"""I$IUUUI*$URI$H$UURUTI$UUUU$UUU@I$O ubinding site for residue mg a 309ac21binding site for residue atp a 303ac5!$681ubinding site for residue mg b 308ac11binding site for residue atp b 304ac6!$6813P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+1XNGAfffL?p}7+3P52Afff333?p})?}}$??G G@K@f7?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13PNG  IHDRc IDATxyս>U>0 , ΰ BDQ\Ph5$'7/ϓ\MM&jk$"FC# [UQ5[LڍχWkOթS=|W$CAxTjs/)-,iZOK,irfk\}O(f| 2?ASWaEo8? H)1-#mْa ] RIR(%9A!'wTolsFA h`ׁdu/!4V(=Iu#+bZJIBp4ROU )% &4YPx -C3Ǐ&lӄ(T@H*. =% Ie5#=)C !݋RPǶRIY;$*Wh@G(l}xt/Ue_7-{LDt[F9$8dR׽蚆&t$MM@:F Oިq蚎&44MCZ _r2^4P`S4HIvtVy6r .D)ɋN0{{LFM-}_^>$nE=CBt*i/a7öh.l5@[7fHH*[lz,I  ;Vݗ!}eS7R lB9Cz<}ERy5KL21Mֶ& rS4f"<7=nM;%RBJftX(%ij==CtD+B6O]yh M!şWޮW=Nn#],c*](š;b YpA[ɂhh>ɞc&RJ@ Q[3D_=Ne)̫@)TtaP3J)SG PI+<`CY.N7 jN* AAZJ{L* ))vׂ+[YIYu­dRRPEިbR_M0L-G 'bzvԋmzHeaavXO H8+4O'TђMcln)crHߛʯZkW."3?/31fz=>p y`CUiYi%ŗ@fzcs10{,a10TJ3vL!&;}'il9ѝu3e9}vTa(֯kGJt$2Fq B3ظ%%0#甠DϾ3 |IJ W_ş^n84?"G:[NqTgwM[V_Mfz6MD'.L8bLO LE!S6%,ye"Ÿ*aOF(  rD(=f^IZZ&p[zcAITӴY]c7's=!9tt/Ұuj"[ {1">q i"<{ބt(L+aT>!OxoG 8|b4y7 8l_G;Ƕgǚ8QETGMgƆ7 / 3{r[}Տlbös=ʊsJlXZc,gVOytRRikktqj&zHƾ#0a,Rx5/`Y/d\S.tTM+&t4MC`ۀͺ$!_VZ10m&N鱭6&ys[4ԳqˉҠ!jGp}sЁ|i|^㊱Ų4IJ Tl~21)#+#]Vdv"!UkY)8||g3hH3 V-"J);fɡ[]u>p+cFC*#$on ͵U0ft) c;01135e%,-% d9x=~,$l䙏=ACEZ,Dl0u9í/TW[Ri:1MBeYJ8b,8g弻IuW!@:I=Oy=A ,,B)ɱS(I0jx+8H%:G?}TiJitU?P[xC8kz3kG;[9i x;I%1RXp2:@r '.՟ Dv vR q$ʼn/(o2j!#`8hD):'RXCsiL3R(c]d)IٜmNRy Lדz† 7 ÈŇm3EoB)/o ˗wDA@pTl`Ic@Pc аlҭFx d琚 )nrjwGRbY&^M7`SOقNOnג=dM5'R35p*Ο?Dbv6i -<>Ǔnkg(vD@uoIy*gv7DiȠkύ|ױHyYlV,rRfuēhJ:SZ0XM$#Jq[X2'C4,^F*8ܯ~J&4TUDJxJNFt"Fp@`:"fx=>V,JP!?5>G= mtV-JoMQn(FxJV9&R('zH$&%QJ2}Dy5sǪI!3%?M !>{N]UJڄRqM[6:ΐI7fcY&H[P$@ck)42RGI V,B1*iF74M oqKf_RWyιCǶcIivИ0uT8cg'lK7P)ʟG!EunH@,TZd|^?͊ybpaf̰x>[rx Λ{j>Ĕʒ[b۾Gx֕#/6> sxcv6t;D Hia>=7z28i7mhШCCC;v숻r%?ӎh` f'3J}z`{PJbZFaa݁Nuk9s`2L@. [/9o!00 74RzBN-$HxJ ŝh?E ̱=}ݪe_w4iXDq>'\Z0ى:Ŭc?63͵i8: ׷~?!Jۿө+ 2{XPr4sF+aF9i>Z >ֈ OG9ZY H  zx%q}ݴ 7ò hj9ۡ744גO\CatC1]ͮ=~y?~;=66!hlg0^:>rG{< |bKK໽2- ) df"sL!=- ѭtJwpAi<RD)|4k֬/K\1uVm`+mp EBr|b#D jXg| 7# JpRxu/mV-[p]wC*࿁ﾛ6vD}x'uM2x~ƍDͱCE1+;4CMIA);R.ntlxQQ<밌v ǒo$l2~>n0 O3*;i9OD˲eCk)+Ēip` +=Ǐa9}Zq}O<ϛޠZW^+'?\f2$hjS443fDMk 5{gfF.Ŵ vp=p7|33C}E]w۳ `),,`W:6mb^UV dG9v0$ \Á3uld䶫~ c΁pb-t2223<Ì3ȠP+y ' %/.beT"L+2lBE/ͻ^7rT; 7ѣG_ ] ĉ|jO>$/h\{2i$iiiAH'WytUY:WMWT՘25*-J Vk;([>7q\rD?d{y!0̐:n# <¡^z)-⣍m_2wvwy'EEEƛwù|ycnS?7KY("lt4NP[)P={ō7ٶm<Ȁ@ \r /|v Ǧb,iu'Z$wμ+BP,!3f`TBBhll}?)pW{crJ"jIlh-ţe*8~[)ҭYf}⦬Kν+>/F.r&6F:Ұ,yzx)zy{p?q^][>`ݯq4^`ڴik2/_}$+]6p}@׽"bhnK'l2!3Wiqܮw^-O_:{m۶徯_K/ĭ@sXt+i`a7u޴K0Omnv4հ \G̜tK\œ6?7c|Vx1f&~#ϪUHfmG$l"bۈ!:Gk`o9MLZ;E͍@ԥ/cmOhqgfʙ:ֽDVSJ:'Ψ9ر:.[P:__^{~{sl?6mcF1&l B*iџѬp5H7;8f q0:!χOG?bٝ}ǝ`쌮+oڙ(xiw;zW{< Ri|/,=[qf+ʽXASS|0l:QKDMRqf_1S.[8|#V:.5b%jIPKl}[l -!~az!.ogO@'֭>J nYu} ZX kۿv<^Ē%F[8XoSu]|K_⮻⭷bŊ\x\|Dq֭K!۔wL6btX n`R<иd=_ug^~! k^zA'?\~KtRQ:~wfDBzs6 C6a1}ww:rݝ y֭:hOA?`a3czɳ;g{x`Hއ /ޔ`l7wV:f'@v{n^9νgy]vo~3A#>-Ww][ThN5Fk>{cj8R%2ćEw>TJ FM;u+aǁٶoK=)Xkn^=nv⛆Qf$f=y{&Q2qԍ~+wo(*8j%mW ݏ@: 2F+7''闱`e|z=b,.^9~l|?0a =F&ϼ過kڟ/ ^M{Ow:/RM# l闁̟vic?2ā1Ip_[CMM Ofƍ?e.w%W# _^© ŗ݊5}R LF3rMӱϘǣl]k?>u=_q& kB۵ПQJ:,,iqEˮ=zr/RIB6Z q7iaGddK'n%E)-rP`ጕlѷg7ϽnV#vY Y~=]KCs-gk,mLv2O ͵44ld*PvhĒ|tds\D*Bt+XcIDAT㿺ɰ|6f241g!f9żyѳV/N-XVT{n233)((d|T;SSѽײ),MLJ9?WYy_XG tݻ,Z(.sx&@QM ńjO8˲#fӌ1ni 3㦕{Sv.o! F]wSN{y~ĥ\4VL^.\ɓٷo_7A O>$r Ji KaOYfr!d#=3+d>oNBDӅtt̲Vd "Ŋsntɓ'@?裘m:#7pwOD y1[QEhBgT|קw[ J+Nێ CFj6m>УQLR{qKsiN;?!|[9t9B~ ({nhm0B?M1͈] ca 34p*ݰ$ l"bm0#fJ%)OAbt o(((F0uf+/=@7&2c.יZp mghl9ř442lm$mS]AvFiٴKt8X93W> ==#G jhu4nz8=!i_Vᖡ-;(z# c4M0Bߝ 3^\M 4 4]d4е_q}m EBn#b1G v(pHC?Pm##_d°NجAP¼e8P4a{kLs=wo]o}_1#wjN.͙r!'/fM:2eR^7AeEB#K.E4NY|4}/$}DMhV(FCI])+|qn̮mb)j,pp$D8$ 5vvEdQWy>5ѿ|gΞ]# ژ;ekfyǤyG8b M$"+cE)lb_V9׶{K>;Jx]uCw#=y9W-lJPJpn8ʹիXswѳU$O(v.:V7ե6§w_:HԞ>rsafMZ9#= hbTCVF`7L;.]_g4+~ijko/v 4͵_t܉u\ݾ1>f cs)u%?E:uSStfg} - PRGӵ;$y}ᚕgtR|i vur- քnIvד/%>1,'|zL,ea)X%jS_謱X´LLt Ow{UVr_D4q?jIl |eGJ$TTni:P+j>.7 V~zW.۝>/sy<4?>|k_˗sM7󟏟Q#:jE3WmM6C(YoHˢ5@fz.iHK"-%ӂVa;9#8`W.T Ey4mW]HZZ_СC dee ki 5a|㩩3 O i)}Xc;Oց+MG l4bTn"!B^<*_@rK6lܧ?H(%фvxQiRSn&*,*@RIR|}xtUh9qDqnUzoöF=!#M(],]`z2r0j0^O >o Ke\4MCIw>T8*g!UdU7 _/愌/JΙ9#!t݃ϛi&Ehg3ɨW*;nN8)Alm!J v !0X<3=Mhxt]Ls&C{Nz]M(MƲ"}*e; Lt.X uÏW%_p4MGI@ys??6>> EMQY:]ٓ/ %4PD¶sI%9xl;2)){`P#glݼsDžH, hLQD)#m4#D0܊ϛJ/o0cR,i!(M#ŗw5cr8xlTjEB<"F*& + c۝`|u(N[̅ o!8LOo<0ȧ[}}iQ)nZe=C)ǏNT me Vޱ|ͮSIi;ڽ>L uq-mghj#nոQ(&r|m3"Yc;:mA+CKi٢.t4B)-{6tUoãy4I^>DV2Ȋ♮ڲLYŻbu'\xkBP2m_9״["MXҊ46Kf>PY6]9g#Zg(,i"+z0o8[HgN^h֕v8ҦE'Z+/x4f9`ԽpY,@ڂr7bDpEɽ3kwl4̓4<44,L*g=GvܨGtEFVtġc)ʟ@PY6'xD,+:RogM (Οi3BAQyHX~&j:6т谅[{S8%%<RIvIePJږLFZ&K\FSE$ ]Fx}54dEͶ44!A贴dn l/%r.|zRt z Ϥqm&2FSU6߉5% Lq[q^Ik\ ]UI%>q%e/{܈(d)q^ہ<7,B'#m-DB짦vUcI3@r O"aGO{Dm͆Ʊd566 )%G߹H[bP"6 *^x3?sΦi`ax16]l4#jJd5)K şތXRQs)p>v9,}M;cA)7lW{x;}G>`LUv-!D(ρdv:M_nEu=7+AQ{T{\phsEL*d|ьtv;ӌDGjww뻡B?)>>[_y`=S*aj"vTbY&[2s>LCs-P눭*ϞC} YbIENDB`move=1000;blend=1000;3P52KK UUUUUUUUUUUUUUUUP9( jTQRJU*WR5??ZZA֠֫֠֯(j֠jjI"IH<WW Wf#?UUUUUUUUUUUUUUUUU-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11XNGYii| kOZjMi_!RP֭ikOZjMi_!RP֭i $"D"""$I"DD"A$IDH"B! H$B"""H$$HB!H$I$D!"  fUUUUU$J"""I$IUUUI*$URI$H$UURUTI$UUUU$UUU@I$O ubinding site for residue mg a 309ac21binding site for residue atp a 303ac5!$681ubinding site for residue mg b 308ac11binding site for residue atp b 304ac6!$6813P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$?? A@p=@@88?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 28PNG  IHDRc IDATxwx\յLӨ[Ֆdr70zMB #/ B*!7$F $v( ) qU*5v8gF]fdy9>{fY{z>|8ph*mW\0ˇiAeNe!(+ZfD[v8LaP7 YV(+3>P*3YH$I#,#^ġMd_f&a2g vk#膎BLaPV!>pѪ[g!B ?=@Sk cŅ3;1}@ K Bi y)tL#@)%' f L[%4ukaRYWs#5%40M4M{{OțFz8iX[*p&|ƜM5S8c o~ȟ>`'L[zM1oJ6\gb:&!$fM^ή Gߗ&`:# CCϿ r#(zRQ<#ņ}GiN]^n^W w ^O n H$~[Rx)7"I2ՇAW9 g20 w>Gg.Y My*0g ,!qz9HglPOKɲ5e 2DYAVT~<1&Rib U"~\9{h!" Q-k4 LӌȒH ͟Evf M2~ 9+GE"|Y0}iyn꼳Y)ŖhD!N/(#<žtC P*z]7-% KhbX"i0oi($HįZ/ex:P59³Ϡ(*H'-DT sƾkƤUw YydgjM/Bx>KZ݈bs kz0b7u%HYiΛ[vk3p6H0oʩD H'olYKVz>B@QTodi0`+HZۭԔ,$W@]t$-{.4Y2\\$_=q`eD0` Om\LT jazЇ<_N/]*Y##5/.9ꦩ'u1.YVeUqa:Gwt;G`PdYE5eôz_Z%>qHp}l9d-ݎ2Qձ7bЄ'O? aJAy+w>a3o# j#l#،nh@ySWRF8ɞ^;_:~o)2pxд(Q19LaX Kx! 0iN$$ou=kr&חw6™L*Mg`ϥy_HMBU:R̙! ¶ٺa9:uC#  F: tc]“iKe S'mCxt=y>rkry) W,sl@Ua]kKľCk?m%,[j[i][k8\I]Aދzؼ%Z띿;$YA%dIbL=*jwP3 ]2h>6;QHNfmL)^-N9(JD$l3dnVȐm";I[qS[GhjC''b0t@1 ݱ\Ut{\ :=;&;ܙBO% n' RsxcIeⲯo$NS9m٠tZu2 ZwRY^F#-՘u"ZyG0ULx$Ir>_^6A8L>]Fjvhq(Ȓb/ މ9ZNWu`p)k$݌)8; *ћ#R`ƨ,cjˀȄGPHxbHd ihSVA Olyt8dY%kKD74:GI&FT׍(v/=w'8!;xLj@V SG >SHK`naM>##5JsroDs!hh8#9F,6"8SKNdvrfM>)1Q{w6h"3=#],[{wq(]Vkp̙r s 0gC[&u|>˭zrI' mN;>`'1" 3U l㜳z|n?.EU]VL>GfD q9 7GCMKT877녈:]/Pc/,p;P+HuyS{3g'55@_%q}aOg87[ 1i)eXtZ_NTף|uMN 9{VCJѢatCC74g{F씒ijI%(+_# TVTGoI+P3Ô44UcbP3sW\al޵>,J1t-1X tI;Ln5NkȐwgM^\~\{ϙ^o:i,J`"OCkk;| :w^0t"x9qjLa2!obݹNOM}%Yǧߧr^~.2 `P֓0,8KQ+WC86~n~ϋ%R/h2eә1m.러:_/"}7ͮE{&4l޽WQ]BϛZ@5̟}7\c\{'O ѨI@ì w ],juq z.9EW28o7믿ά JEUqYBi8Wݻ] {M`τJ: 3xc%sEUT8H;_Lwp*[B$в#L{qiɺQhAZ3 \+9p흍tR7y=P&P__O7x#.o6?0`f͚ł HMMvHL!Rzf<svz,\z+dN[6-vNI$xɪ۷A7~d?~X=_aGp;;],bgjl1LBѰ-X<6ZܩvQ@s[Y0H!拈AŒ2EZ7Vt;w<  ˖SrG/F4A'CMMQi }hZtկl}[[٬KAR-}z8BBb3ɯ RJȑC4VGs{݀PYe,yg߫/'&k0 v\þIesleq >gub[#[zW':x`u1>wJ*7"$ˢΏ,ۭMd >O*0Zl'\iBSo0ȁQjL,bv%IBih~gXnKr0(V=+f~̚5'x^z9nolƐIaN6*Vt}k+(+)-I?w[(}cy&84ֻ& K#q8eLKylaN̟"~75;<'y/b蘐gip$HuCo-e9`odgbs3/ۀdeem6N>d֭[jG[ub(ʛ@0DL۷osyւbZ[[yhL-s(a{6x~_PYBXHveV5ۙ8~6Ғ<4m ]xʊv[H4D}cymcaUKȶ˗+na:g'y0Ge l޼*vɞ҂NPB؁f{c6}Lqk:N' $d;PXe 3+kws#cG NN3o=N8I kpv7>8hxx=~4B`Z):Bwp7Zc)?IXQc!'h(zV;Fbz*Ē@BN cXUTiK-u6^Mi{TUU1wDŽ0*:},`i2y|*+Tˉ}u ׽D}|}!V*v4ԲIJHX8qJ8۴is]nRm&0:M`?μy=x6[khjX#Pp{B'Ap60.@$_x 4OM% Px[n塇bѢEdog> ; i’%wP\\/︃wcc07'QcIyBNLa ȟZ^yܪSBm4԰fah2~in!]k}}yB[~^xPꭥw:"C )?o #iX0t甑QH/G: G4׳`*|tܪxۇuUVq7rW>_\ VkYy_Lx횣o?&ϔ[F^v .ՃE ¨wY4pGC[o͛4iN^:N 蝸2KqQ|q=(l y܀cǁ8tx/`+ilRS2VMH4H8jy;; >5kpW#^#SA'8oȲvZ~jkk Äa L $I'%끪ɫ2tᗁ'>^)Ζl$\x3ryь(Ag6lQUWIDAT٦+>JQEjj*җ:|8C…ѵᯔR~7m_>5Д)Sxד2e˖%5+$`eYQ;T 4ukL4e˖9G"4J8 HQ$\r%l)//gʕTUUqgbYfُ=&'selכi"֤yȲ"+vp4fڴd (q˞HnV2&Tx\EQ0x=,T=Uq -pUEb8묳 -Ȓ$VVDܣ,u=1NO%?Ԕ, |4<\Eq 9\$tKGQ6)þGpVw} v9s~]wQSSÖ-[Xn֭;0qn$/hY<cr"p?'tWWS0M?IT Nj/ٳ)nt>'/MqY~!5% ,@0.cl8PVZ'G4jR$Ter0L=&rfN%˿{[sjEAc!+C$)n $\ $dںF$*ve~5kk}Lp̱Ґ w;ľ8o3euL|֐[V #uoPB 2سN qjFAce") Msi8/,t=?mz5}ܼ|r ' Dss3-MaE GT=QEoV&.Ic\f)9GY߻ju7ӧ}1 D.KYshL,g1`yk?ࡇ:#:f(.A85@͑n5p溋^KUy\) GϏFCBA˒]ֽMi ^@VZ>yv4Wp8NSٲeK¨GdjA`:P hI|M'y+,{22fPa)uBQ,#;/IqP`+phM2!o*nUu*1V/|qLaSPYAM>Z:e/_sK<܁kȲ#8OY\Q,cĉ9E햽$Y1kGHD# X4=B0NA$z._nTˋ$S]tbw&2DPdt̀_"0b*qU^Ij%?bTYV8RH4bE ~I|_49,S7bYq::-M^@$Lp‘n=Xi<3\tEz(E(0-Gc\<7V\W¤0$cFD?jz).c=QAILt]#js8D c+Cdy"V7tڵ>(̙L(+]eаS3l͓\ Y/&;ȾcbƠz>+.dlWhÆ ,_&qWJX ڮWݑ@VLHg;~?we ś~F7|fq%+'8PU7$Uđ}\x<v$]EnY%-% 4zH56 A·dA]H;xmxmvŧul_hk @U}\[jCL,jᤌ!-xWCS g5M5T"3-Yy(9YKns4Y"z Gym#Igqޝ:f8Ș'J"T!LGpb¥Z]KB)LzS444:E?0 ڛ1LE30uGtJ_o$aiM1oک|i%'rwח,eI@`I*Œ<&odABiQHֺGUEABr[G!Zחw,p7hko% QqhtCC5_0uwe76eټ q-/So3ƞ8,6-Xu>?,0 [XƱeiUQ44W[i))~<^za4]gضu@ ‘C\s8yJvF!~O;@X=e][BXݞsŵõ߄?R*?fPVc_|9dYFu~osz+WT@Ulmi.Rʺ 7*62D$$ZJ/@74TEvz!e))HtƦ,r+iuJ.=?S,&Q-LT pw(|;wdoqoE4Eqs)t\3Cedv4֒Ɏo1c._}/o| d{YOB71 s&3pM)1#)J n"jC#fN"x<)xݩx=)2XZRiH󇧿 " vy9l:H%ZRDM:[0IE[:~6M4M6Rz/^#<raa?%6o9SKNDhzǏaaKq v܀x bFö-*.BLvIVu`@ƶC4ֲ}Z:wk8BK{=J [ Z6*,v IYP"GQd047$p|w6q1dBv!\Ra 4W#I2a+n'4I8ruҵD0A{C8-*#(o*i~C{g'dak/]|74پn.8&L ͟,̚dM-7!(Z3 EJZJ6H'9(7IhzI:퀄Kuh$lP>ZlE!Zغ!O)9ln&EIld2kry5!cq)H"RW|膎qxKt+~+UL[k,Q EhlC ͕4K6) /E%j`M]sz+;ilHIs ZIM  ac0gE WiB80 \9aDH!QvTɑ$xЗͻ.MS);~B4j}*vQ\AK{=)txя0!oj~zMLӠϴ 4[>*.n޷Wn 3&-,Vc'IDpR8N9ˇ)L:l7jSJ^e.:CmB#:?[ }\wqoNbbl'v MFU{ ϫ=i]Qt=Hֿrgfk-Y!E:hlFVtT&iچҧkEv&W5Uqq㥽MJyyvɎJ gRTa x9uU.&M``:H稔v7u"tZ!;u݄gEWY < gQ? O}S9B{L>MI*8KJ-xqoQxas@[{[v&.H{+O֐{yFU v?.ƦS,{>i)ٴw6QTNjJ&\Pȍv!8"\'-'QZaETBccmFmgX6>*i0o /BvawF`_ŦQer"0]S3Zah+dR"([ .рXu饋%_FW>5 Xv wI2 $z´)ƒ9:]r л `_Q90s5^ٸ!7tqli1.J{6efi׋ߵI,I( /W?nsدC?XZ& ŴCറAu3mn1Cz揍irVX0A\] N^>mG%8e wgΫO00&*[}pT5FO'%IV,Av)/~o:>嫿xd+~th[E\;3t剟aZlX`eUvꐪX[Gq4~>Ѝ(0HO$ ,+^"TqG.Ʀ] 㤾*jv`f ֚4 Tz-^q&>;eVrMYo<,  A(ISˑ}QlՁ;RGIENDB`move=1000;blend=1000;3P52KK ?UUUUUUUUUUUUUUUUP9' jUEAAjHU)TQR*#Z?ZZHD$<WW Wf#?UUUUUUUUUUUUUUUUU-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11XNGYii| kOZjMi_!RP֭ikOZjMi_!RP֭i $"D"""$I"DD"A$IDH"B! H$B"""H$$HB!H$I$D!"  fUUUUU$J"""I$IUUUI*$URI$H$UURUTI$UUUU$UUU@I$O ubinding site for residue mg a 309ac21binding site for residue atp a 303ac5!$681ubinding site for residue mg b 308ac11binding site for residue atp b 304ac6!$6813P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???b,$b$??lg=@0@??????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3PNG  IHDRcIDATx{xT?KfHQpKxABDP*^VXgu<ۭ۪mk(" $ Aefy33I$LG_̙v~$..19mK%f\Č+q3x\bK̸qW<.1%f\Č+q3x\bK̸qW<.1%f\Č+q3x\b&iS`ˇNҁHHߏLKsڔ I{ o:kNmE9p4nk#P t֜AҔ<ngH:u!=B[ߝ(iIesz +BU>d%-'ӛ*0u-JJmY\?zJWn3h] ݑ5UK.)HN:H:]RAh̗wWOIJ,]j_V}0Z <]2%t: %5sW $I% 뎾ffV MXW&)34-|6Ժ%3 ԣo?O5y'3r֜E‹v;jE#) Ü(ޝRiSb&F" ;mH+pKxԬDC ӆW<+-Lh%x"磿N*\8ısf W<gѽ{wh5MW7=sҚ<0avIIIӦ W<piZ6U=Wb*++͉'ɓibqߙ̩@ڵKGzo׮]~vƘ7 )SQQO /qo@[)mDYY/_& Q\\Lnn._o |xG͡v\ M9991's@IIq7 1SY?-EVAff:_7/so>͛w.mk+ e)3gd˖-[oHOOĉYP(ď^}iӦ1 #C8m&XMriZVJŋYz5S6k> 1JW4zΏP̭hpNj^_ȷ;IlY% `&Yt|wIa +?q]ar܀f_|Qou>/|W4k?K,ł-J<ßO/K\x\lYoذA~' -S\YUrssYv-\|O2^ %Ip~/0c ֭[׃>i,[S;^'T駟fL:(l$\'Yt)K,i+WK.TUU֭[B~f}~ȑdeeqFXlO<QΙ39sУG:̙3ٴi?|3H8㏳pF8q".]b߾}l߾~;edd0vXt]'==<=;`L<M M &<RJ~Z}C2j(OB< }H4]*Z$WH)uuu5=Hg- ) i`zԶnw] X%2w /fmxUKB<ӲGׯKJ!mء3&{_wFO f~k],f˟R4]ڎ\] ~=FXXG'nf}LDmWv 7Aٙ9!uF̵]ro:OEv-\+hes߬_]RCԝOJlݻJՅgﳹ`%@TnmzMmoγx܎@"޿WPЮ]k5rY64=&Ƀw>_?yl/{>~Yy%:q%@!D L+f3%ݹhF ]PCwޠPJ]N hTLdrJ9tQ~Cnw*]ak2SOQQQm}OqC)%[j$qS)؏S}9zF̲:Ya>gyF5qh$v&qgь"TT!t#Ķ`YF"px6a? +D }m?jSGݖC|E>Wsrv#А /(zIt3[oIJSgK9s]WGݖHz56}_K8TǀGvRWlN} Eg$vYx44zZXm%A&fƾ&7+,T?i|8C6e1ep4k,י`{K6]PPMi;玶8c%Uxhfh,yg R sۮ*uxxZ?sHlOD4 @ѼHiF[öAJ&oE+45V&᡹?VD[ U*uZ#۲F5͋ǚil.Xi$2k 4 R8UHR6PHMs4qΣZ7G HSj V6~O5<ϒ] +]PTɥ)Hq5q}&4_Mܚ9ϞTSSw2s5u(<>٭#ےRWExx<2gmى߃Uٶw5;>6p꺋tڋ6)))\fhY"U%Y_RJD/=7~~WMsr:jC"x Cu 9Z_ٵg;x6@JOF'u +<q^Uu"K+=u&5%%%>|=qǍEH2iXY(5[nY=7M;:wFuF yCle=uS})ml}{5׳x]~'@At=dCT%Bi<戹&4st;ٽ6'n04#/HxDt~o .*ώF\`M3-~&OC4 pVݑ;X ;l~I͞l_!3I9ϸ=[k5G;.Xrl%\-0.{ t]HOFtrU0'W|KX&A{qWѽk/;bN  ;m^Bѵ' .p~yFRn[U"hVN:lYr%ψi^B=n!b9MKR<L魺֚3wڼ!)ЌsVOk>yj` P kSyS&&% Ixshn_܅BI^7 -!& 2ؑtJ邔P˩!#X\ 3H) Y i RN{%ƛ~.q±xTdӋ՟ig ATaI ]ϫ ƅxFi.caj0(* ŝCҹ~ mY16 =3)#.[S313'B0CDd4( [q"- A:0&xh &)4,aNGzYL9_oC%?ðdHɉΟpBfOu3r4ӭU .Q7_䍺|/#$D㷻%Du |H%]Ru$iF6qҨfS CgPΈ1[h[FH*^{5ͼuQX+"~фQBFţyz|x4l[hXkX :BHP ]>>3r]WM<]d (~Qn"DgMuJjǡfs=-crԾ/{!T wuL@p)BzP(ȱ2z]*}[/Ev]RRR;i7SbZMj /gi2&aj5w`晃_Tբf sy/7dgԗNFR8?fdi`, gpy>s/IՅ dVkId\?>km -Z~YRJ{eÑo`U5Zڶ䙞M;F({Gw˙ʜ#՟i\*uc8ׇ㧦WpD zawnj2.yd ö/k*̞4jf-.F"j%9xl=Pq5f=)Φ[M r-]-)o|jñSySk:@ hðHl& ;Fj;< FbO0*3'$՟f#5k _qs]:{`(]o}Tߏ׏Sd!ݐ~Yv矮yミ7zhV3'-iN,a=ƚ%պ 0YdKфp9;zuH p;]/U yյHwBJIqg Կ+gԧaZ˪ڭ@H8T1}|鉽-2.kJD:=B׃mbIxmz^iJںjNHUw3f]uIENDB`move=1000;blend=1000;3P52KK '9% j/UZAEE__j/_V)AJ Tj/֢j/j/ IH<W#'-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11XNGYii| kOZjMi_!RP֭ikOZjMi_!RP֭i $"D"""$I"DD"A$IDH"B! H$B"""H$$HB!H$I$D!"  fUUUUU$J"""I$IUUUI*$URI$H$UURUTI$UUUU$UUU@I$O ubinding site for residue mg a 309ac21binding site for residue atp a 303ac5!$681ubinding site for residue mg b 308ac11binding site for residue atp b 304ac6!$6813P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???jj$??;<@.@4?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4 PNG  IHDRc IDATxy|Tٲ'$- `EֶZ>>yj۟lV>U UEde' rܹ$!y^739gf>=|$iāI]I7i񤉛xMZ.ӟ4!y,^XrԩGI{N |8!9:t%K0c <3 I;HjkɼeQq(lYxqBozj6lؐtS.#g$oqmܹ?1c^;CJ?>R?ϋ.{aԩۗN2:mۖb꫌? #HqL6M?tYgu8z?|~_K MC^4+T(^Um~.\ȸ7]ܴnh7|I\wygyӯƭO MhhGυvf~M|gm>Q`cŬX,쟯^n{7 "jkkk>|xʳhѢ.4MCJ)m$ u٭.z3M7݄u.B`\{x^ϟ=<ӧ;w<FJ-%=1Iggn?̴]g„ PCxt/݇m>U~k;~Ni[=͉-dĒ7=4MG4Mym64MGtE!t:)>| | ǣsiRj[Yx nݪ&r$D Bǎ5N-%JK)-򞊋&̿w'W\5g@h ^o<.x 3&ƹfufJ\wuH)s|c/>$^OXfToɆ 7n!b@Je##p/*&%~qO /'eXI8܈e[Ĵ ,P uMG8 \.p#7S3f {.*sÆ _~Ǐ@`Ik7|vZ|>3vlsLu, D"- X5kg{ 'c&XO4#C7J3Vmx%,)Be'&pxzc+(ug9]+hk[=.X/COrx<7wxg%#=ֿAEg!s,.bٓ0PV()I0k򜄦7@'ЖѳB0$[ZM6nݺq&xҭtgL-iWVV" "VDBq,0x,NhQlق;-iiX5cҭ-Y;7TvwUtU(H,_lqTM ,Ѷf{!="X bRm ^p&#J'b} ;!S wLC8\);w{:;xUsf3LU<3&ݦ $HYV:1yNe}b,Li,X s/} rs"2!T cҋ)-x]b?-^]ogS)̽@C~iE00sNZ622s$|iSul_)?2YL‚";;!mc7Κ`y睌^.eb6gIJZ4fچ~5Fd)O晫oӊz V+@0#44?H^TbyfNCT;qS'JI r]Hv?k_i4z|_v^wwPXMөo< @NlBJ~ȧO;9%oxwӓ[F/B6[hy5 / m͜rYK‰64}#+V|ryxb^/Bx/܈y PXC}c k;6Ҷ]ǨR ,n|YDcI@O6'nTmiuim\:SAgU͗$ P3s_r#АBRU9wT."j[RJ Ÿgz)~a%Zdg!=HNV_lic8s6vkB/r_{oy#55MZ2 aɺ;fG6M]3303cmHkjкG"A}"* FU`ٲe<G`ܯO#Of{D眲 mz96"FPPāߚk Hrrs4&~K +wRDIR~m0bPD*W fsNUF E2^dXƟlp$b0g,*b G!û&#E]C EE< \uW0L40Lm2:ՁtѷYF8ĤїиGx-)Qcn%eS^@3q蚲ȍZ&}ƲU=#*$۶}mJph<.aChy?kw;JgӖ溙3xR JJ'qkI ټs)FgFpì߷R1mGj13m=qFh[P/=-Ka8p߾mj[ڷɝ8U]PTaF/0t,%&E'YOݞQ4Z -jDͭ5k{${}O̬NZ"D |7ͷ!Ǝ,ӊ:YэE<JH{C&slRڬۖW_tF 7:]8FC qyYұ*,؉C&,ؾoe: -mVo^ycD˾҇xcӰF0CFj7TȩLn/,d8l:ٙ9(,~Gi 6(3m{>tBL59cY]w +[.{7>5QD0a3v}BwKds1 #G_ 3LMm}iF8XڶgP`U9cLzIwVKǺH #D1‰Gq 9K22x >_elٺ?ʈ҉4k9xh/GN5c?u|ض=+4c(&>6]jV #.+pHS 3Qk²MBFs2ٶc#p*eTnዴ%Is~ OyVJ͊"Fȍ( 1a7=Sќ֩ĶMW'l桌-uۓ$|DE6JFzںȭ[#-%U_@su54jmWygp4G)0:ƑzJR'&a33?S3xMZi}6;عkD}HY}}`7, o u<_\5^| 4MED#t̓8VOۊy.8jh:ѥ1ٙN4ZSq,`7j\5fhÌ`Z'ihƒߗI{܈d//YCm]9;ǝyE^_-MBƸMu/m1_7G Sk,,3'pB ^ֲN3]ikգϕh+ [yt_Oɷ;ɼ*R$H :˜ VqG܍s KNf> ے<^]`ʘs% C[=DA ;!vmwi~N?u2W/ 47 M]N׈I}N| &,l U~+bZ2 U@~N!yme>V%vD=؈DKf Kܫ M E5x 66DE[4~->*2AJ<?et>&@  5 7+=b$|Y#?9}-iJjrvEr Rڭ8FO9YO~s ,mI,ˢ>tniM>r܂=(Bum:++v@nڵK 8ģӵ&}9CAJ!طGOMmGWgTGcS=ZsR}lXܯ ځ-6Tgr@YdF?‰#e%+C-,(Nh|MOڶs?j>՘AĩH̶ԧt>O?ܬ|rr].2eM%oPulebXawX#D0mv8P:`4HIb,+il߷Sū@G9a. (%3q UéU&,Cydr8RSBp8Ns7Yxt@´"|wIM^v!#*$]{DN]]h31.׋a#|#ttї ͊PQPquln)2 JF9﯉wS ,DRӿK5Nt.o%f n93nnF #`DD4MwYV$%ֺOE}""fP#o (v;T{҄atqY;CDO'C!N (WZmԾ'9V`O5œn0cKcThwhq=M9uj/1$±7kj`MLXӍe2&4 ;Ҽ%` `K- 4MÖ*NݰS!bZ3Ʈtw <v;j-Db]ta;¡So;IhZATƏ hƒyD'v=cK-"Q *t6i_-!}5W$Z*4#j/3avkNZ4/U+ӳĖIg_lOYIDATL3"Op{?y4#$'<ykwV-tNk(~ e9.ıh\J1iTIENDB`move=1000;blend=1000;3P52KK 3UUUUUUUUUUUUUUUUU9( jUJMjj֠֠P?j5?**jS**'j֠֠Ȉ""DG<WWm#?UUUUUUUUUUUUUUUUP-vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11XNGYii| kOZjMi_!RP֭ikOZjMi_!RP֭i $"D"""$I"DD"A$IDH"B! H$B"""H$$HB!H$I$D!"  fUUUUU$J"""I$IUUUI*$URI$H$UURUTI$UUUU$UUU@I$O ubinding site for residue mg a 309ac21binding site for residue atp a 303ac5!$681ubinding site for residue mg b 308ac11binding site for residue atp b 304ac6!$6813P52B11,9<@,9<t j_j_WR֯j_ԿZ///jZjZAK/j_ԿԿZ֥_T Կ/j_j_j_ZԵjZRj_Կ_KZ֨ Rj_ԿԿԿjkW/֥Կ" " " "?RRjZP@+R֥ԿUkR֯j_KRD@D@D@D ,]%7m pf!'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm'IUU?䈈I$B")UURHUUUUTE$I$B)"C0|?!  'IUUA$DDRI%UUURJ$᪪")%!BRI$H!pAIKmmmmmmmmm$IUUPCHJ""UU$ UUUUUHDRJI$"$0C!? @$IUUTDDE$UUUU!"NB"PB!%$I|!HBI?A$mmmmmmmm۴vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES 1Gmet->mse selenomethionine MOD_RES991Gmet->mse selenomethionine MOD_RESrr1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1Gmet->mse selenomethionine MOD_RES1G~binding site for residue no3 b 247ac27pp 1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES 1Hmet->mse selenomethionine MOD_RES881Hmet->mse selenomethionine MOD_RESqq1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hmet->mse selenomethionine MOD_RES1Hvbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue no3 a 247ac191met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESrr1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue no3 b 247ac27pp 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES 1met->mse selenomethionine MOD_RES881met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???0K;!l@/\)Mnh(3)-dependent nad(+) synthetase; chain: a, b; ec: 6.3.1.5; engineered: yes3P523p52P 3 2 1 BBB ??@ ab??????z^ Xno3 nitrate ionawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28 _ala  _mse   _asp  Htrp # !"" !$ Hgln $#%',$&%$(')(*+))- Hlys %-,.05-/.-102132436 Hile.6579=6876:;9<9:> Hthr7>=?AD>@?>BCAAE Hglu ?EDFHMEGFEIHJIKLJJN  Hlys FNMOQVNPONRQSRTSUTW  HmseOWVXZ^WYXW[Z\[]\_  Hcys X_^`bd_a`_cbe  Hasp`edfhlegfeihjkiim  Hphe fmlnpwmonmqprsqtqurvsvtux Hilenxwy{xzyx|}{~{| Hgln y Hglu  Hlys  Hval Hlys  _asn _ser  _gln  _ser  _gln  Egly Eval Eval Eleu Egly _leu _ser  _gly! _gly" Hile # Hasp           $ Hser  % Hala & Hleu# !"  $' Hval$#%'*$&%$()''+( Hala %+*,./+-,+0) Hthr,0/136021045337* Hleu1768:>7987;:<=;;?+ Hcys 8?>@BD?A@?CBE, Hlys @EDFHMEGFEIHJIKJLKN- Harg FNMOQXNPONRQSRTSUTVWUUY. Hala OYXZ\]Y[ZY^/ HleuZ^]_ae^`_^bacdbbf0 _lys _feginfhgfjikjlkmlo1 _glu gonprwoqposrtsuvttx2 _asnpxwy{xzyx|{}~||3 Evaly4 Ephe 5 Eala 6 Eleu7 Eleu8 _mse9 _pro: _thr; _gln < _ile= _ser > _asn? _lys @ Hala A HasnB HleuC Hglu D Hasp   E Hala        F Hleu G Harg " !#H Hleu#"$&*#%$#'&()''+I Hcys $+*,.0+-,+/.1J Hala ,1024513216K Hasp26579=6876:9;<::>L Hleu7>=?AE>@?>BACDBBFM _asn?FEGIMFHGFJIKLJJNN _leuGNMOQUNPONRQSTRRVO Eglu OVUWY^VXWVZY[Z\][[_P Etyr W_^`bj_a`_cbdecfcgdhehfgihkQ Elys `kjlnskmlkonpoqprqtR Eileltsuw{tvutxywzwx|S _ileu|{}|~}|T _glu }U _ileV Hgln W Hser X HileY HleuZ Hasp[ Hala \ Hphe ] Hile^ Glys _ Ggln ` _ser a _glu b _asnc _thrd _thr   e Hleu       f Hval g Hser  h Hleu !#' "! $#%&$$(i Hgly!(')+(*),j Hasn),+-/3,.-,0/12004k Hphe -4357>4654879:8;8<9=:=;<?l Hala 5?>@BC?A@?Dm Hala @DCEGHDFEDIn Harg EIHJLSIKJIMLNMONPOQRPPTo HileJTSUW[TVUTXYWZWX\p Harg U\[]_f\^]\`_a`bacbdeccgq Hmse]gfhjngihgkjlkmlor Hser honprtoqposrus Hleuputvx|uwvuyxz{yy}t Hleuv}|~}~}u Htyr ~v Haspw Htyr x Hser y Hala z Hleu{ _lys | _asn} Eser ~ Eleu Eval Bile _gly _thr _ser  _asn Hlys  Hser         Hglu    Hleu Hleu "&! #"$%##' Hleu '&(*.')('+*,-++/ _gly(/.02/103 _tyr03246:3543768977; _gly4;:<>;=<? _thr<?>@BE?A@?CDBBF _ile@FEGIMFHGFJKILIJN _tyr GNMOQYNPONRQSTRURVSWTWUVXWZ _glyOZY[]Z\[^ _asp[^]_ae^`_^bacdbbf _leu_fegimfhgfjikljjn _ala gnmoqrnpons _cys osrtvxsutswvy _ala tyxz|}y{zy~ Ephe z~}~~ Easn _pro _ile _gly _ser  _leu _tyr  Hlys  Hser  Hglu  Hile Htyr  Hala  Hleu Hala  Hlys  Htyr             _leu _asn ! _leu! "$(!#"!%$&'%%) _his ")(*,2)+*)-,./-0-1.1/03 Hglu *3246;354376879:88< Hasn4<;=?C<>=<@?AB@@D Hphe =DCEGNDFEDHGIJHKHLIMJMKLO HileEONPRVOQPOSTRURSW Hlys PWVXZ_WYXW[Z\[]\^]` _lys X`_ac`ba`dcedfegfi _phe ihjlsikjimlnompmqnrorpqt _ser jtsuwytvutxwz _tyr uzy{}z|{z~}~~ _thr{ Hlys  Hile Hasp Hglu  Hgly Hleu Hlys  Hala  Hleu Hglu  _thr _asn _asp Hglu  Hlys  Hleu    Hleu        Harg   Hthr!$ "#!!% _leu%$&(,%'&%)(*+))- _asp&-,.04-/.-1023115 Hpro.5:468;576598:49< Hser 6<;=?A<>=<@?B Hleu=BACEIBDCBFEGHFFJ HileCJIKMQJLKJNOMPMNR Hala KRQSUVRTSRW HmseSWVXZ^WYXW[Z\[]\_ HleuX_^`bf_a`_cbdeccg Hlys `gfhjogihgkjlkmlnmp Hasnhpoqswprqptsuvttx Harg qxwy{xzyx|{}|~}~ Hmsey Hgln  Hlys  _asn Gala  Gphe  Glys  Ggly _lys  _mse _pro Eglu  Eile _leu _glu  _mse _asp     Htrp        Hgln  " !# Hlys #"$&+#%$#'&(')(*), Hile$,+-/3,.-,01/2/04 Hthr-4357:46548977; Hglu 5;:<>C;=<;?>@?AB@@D  Hlys <DCEGLDFEDHGIHJIKJM  HmseEMLNPTMONMQPRQSRU  Hcys NUTVXZUWVUYX[  HaspV[Z\^b[]\[_^`a__c  Hphe \cbdfmcedcgfhigjgkhliljkn Hilednmoqunponrsqtqrv Hgln ovuwy~vxwvzy{z|}{{ Hglu w~ Hlys  Hval Hlys  _asn _ser  _gln  _ser  _gln  Egly Eval Eval Eleu Egly _leu _ser   _gly! _gly" Hile# Hasp   $ Hser        % Hala  & Hleu' Hval!$ "#!!%( Hala %$&()%'&%*) Hthr&*)+-0*,+*./--1* Hleu+1024813215467559+ Hcys 298:<>9;:9=<?, Hlys :?>@BG?A@?CBDCEDFEH- Harg @HGIKRHJIHLKMLNMONPQOOS. Hala ISRTVWSUTSX/ HleuTXWY[_XZYX\[]^\\`0 _lys Y`_ach`ba`dcedfegfi1 _glu aihjlqikjimlnmopnnr2 _asnjrqsuyrtsrvuwxvvz3 Evalszy{}z|{z~}}4 Ephe {5 Eala 6 Eleu7 Eleu8 _mse9 _pro: _thr; _gln < _ile= _ser > _asn? _lys @ Hala A HasnB HleuC Hglu D Hasp       E Hala          F Hleu        G Harg                       H Hleu     $     ! " # ! ! %I Hcys  % $ & ( * % ' & % ) ( +J Hala & + * , . / + - , + 0K Hasp , 0 / 1 3 7 0 2 1 0 4 3 5 6 4 4 8L Hleu 1 8 7 9 ; ? 8 : 9 8 < ; = > < < @M _asn 9 @ ? A C G @ B A @ D C E F D D HN _leu A H G I K O H J I H L K M N L L PO Eglu  I P O Q S X P R Q P T S U T V W U U YP Etyr  Q Y X Z \ d Y [ Z Y ] \ ^ _ ] ` ] a ^ b _ b ` a c b eQ Elys  Z e d f h m e g f e i h j i k j l k nR Eile f n m o q u n p o n r s q t q r vS _ile o v u w y } v x w v z { y | y z ~T _glu  w ~ }  ~  ~  U _ile   V Hgln   W Hser  X Hile  Y Hleu  Z Hasp  [ Hala  \ Hphe   ] Hile  ^ Glys   _ Ggln   ` _ser  a _glu   b _asn  c _thr  d _thr       e Hleu           f Hval           g Hser             h Hleu      !          "i Hgly  " ! # % " $ # &j Hasn # & % ' ) - & ( ' & * ) + , * * .k Hphe  ' . - / 1 8 . 0 / . 2 1 3 4 2 5 2 6 3 7 4 7 5 6 9l Hala / 9 8 : < = 9 ; : 9 >m Hala : > = ? A B > @ ? > Cn Harg  ? C B D F M C E D C G F H G I H J I K L J J No Hile D N M O Q U N P O N R S Q T Q R Vp Harg  O V U W Y ` V X W V Z Y [ Z \ [ ] \ ^ _ ] ] aq Hmse W a ` b d h a c b a e d f e g f ir Hser b i h j l n i k j i m l os Hleu j o n p r v o q p o s r t u s s wt Hleu p w v x z ~ w y x w { z | } { { u Htyr  x  ~    v Hasp  w Htyr   x Hser  y Hala  z Hleu  { _lys   | _asn  } Eser  ~ Eleu   Eval   Bile   _gly   _thr   _ser   _asn   Hlys     Hser             Hglu            Hleu                 Hleu                ! Hleu  ! " $ ( ! # " ! % $ & ' % % ) _gly " ) ( * , ) + * - _tyr * - , . 0 4 - / . - 1 0 2 3 1 1 5 _gly . 5 4 6 8 5 7 6 9 _thr 6 9 8 : < ? 9 ; : 9 = > < < @ _ile : @ ? A C G @ B A @ D E C F C D H _tyr  A H G I K S H J I H L K M N L O L P M Q N Q O P R Q T _gly I T S U W T V U X _asp U X W Y [ _ X Z Y X \ [ ] ^ \ \ ` _leu Y ` _ a c g ` b a ` d c e f d d h _ala a h g i k l h j i h m _cys i m l n p r m o n m q p s _ala n s r t v w s u t s x Ephe  t x w y { x z y x | { } ~ |  | } ~    Easn y   _pro   _ile   _gly   _ser   _leu   _tyr    Hlys    Hser   Hglu    Hile   Htyr    Hala   Hleu   Hala   Hlys    Htyr                    _leu          _asn                 _leu      "       !   # _his   # " $ & , # % $ # ' & ( ) ' * ' + ( + ) * - Hglu  $ - , . 0 5 - / . - 1 0 2 1 3 4 2 2 6 Hasn . 6 5 7 9 = 6 8 7 6 : 9 ; < : : > Hphe  7 > = ? A H > @ ? > B A C D B E B F C G D G E F I Hile ? 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! ! 7 7 7 7 7 p p , % p p #binding site for residue no3 a 2479ac1F:q=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine 99MOD_RESp=met->mse selenomethionine rrMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp#binding site for residue no3 b 2477ac20F89#binding site for residue no3 b 247ppac2F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine 88MOD_RESp=met->mse selenomethionine qqMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESpBK[@@?AA@@?AAA @@@?AAA A0A@ApAAAA@@?AAA AP@@@@?AAA APA@@?AAA0@@?AA@@?AAA AP@@@?AAA APA@@?AA@@?AAA @@@?AAA A0A@A`ApA@@?AAA0@@?AAA AP@@@@?AAA AP@@@?AAA APA@@?AA@@?AA@@?AAA @@@?AA@@?AAA AP@@@@?AA@@?AAA AP@@@@?A@@?AA@@?AA@@?AAA A0A@@@?A@@?AAA A0A@@@?AA@@?A@@?A@@?AAA0@@?AAA @@@?AA@@?AA@@?AAA A0A@@@?AA@@?AA@@?AA@@?AAA A0A@@@?AA@@?AAA APA@@?AAA 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1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 a a a a a 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 a a a a a 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 a a a a 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 a a a 6 6 6 6 6 6 6 6 b b 7 7 7 7 7 7 7 7 7 7 7 7 8 8 8 8 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 10 10 10 10 10 10 10 10 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 12 12 12 12 12 c c 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 d d d d d 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 d d d d d 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 d d d d 16 16 16 16 16 16 16 16 16 16 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 d d d 18 18 18 18 18 18 18 18 c c 19 19 19 19 19 19 19 19 19 19 19 19 20 20 20 20 20 20 20 21 21 21 21 21 21 21 21 21 21 21 21 22 22 22 22 22 22 22 22 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 24 24 24 24 24 b b0K;~F@/\)Mnh(3)-dependent nad(+) synthetase; chain: a, b; ec: 6.3.1.5; engineered: yes3P52B13p52P 3 2 1 BBB ??@ ab??????z^ Xno3 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