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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05082
(
show subtarget assignments
)
1
cloned
No
lmo2179
16804218
-
peptidoglycan binding protein [Listeria ...
1152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
2.3%
Listeria monocytogenes
Regulatory functions: Other
IDP05002
(
show subtarget assignments
)
1
cloned
No
lmo0086
16802134
-
hypothetical protein lmo0086 [Listeria m...
1959
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3TUF
2.8%
Listeria monocytogenes
IDP00192
(
show subtarget assignments
)
1
cloned
No
YPO0947
16121251
-
putative virulence determinant
3110
Virulence
Phase 1: October 2007
1AF0
2.9%
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP91916
(
show subtarget assignments
)
8
selected
No
SpneCM_010100001122
298254201
spermidine/putrescine ABC transporter, p...
2168
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3D31
3.1%
Streptococcus pneumoniae
IDP92138
(
show subtarget assignments
)
8
selected
No
TGME49_073450
237833297
sufB/sufD domain-containing protein [Tox...
1267
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1VH4
3.3%
Toxoplasma gondii
IDP01916
(
show subtarget assignments
)
1
cloned
No
lmo0327
16802372
hypothetical protein lmo0327 [Listeria m...
1348
Predicted virulence-Invasion; Predicted involvement or location on the cell wall...
Phase 3: June 2008
3M18
3.5%
Listeria monocytogenes
Central intermediary metabolism
Other
IDP91511
(
show subtarget assignments
)
8
purified
No
VV2_0479
27366913
autotransporter adhesin [Vibrio vulnific...
5206
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3EEB
3.7%
Vibrio vulnificus
IDP90174
(
show subtarget assignments
)
8
cloned
No
AAM13466.1
20153005
CPXV019 CDS
CPXV019 protein
796
ankyrin repeat protein
Community Requests
3HG0
3.8%
Cowpox virus
conserved hypothetical proteins
0
IDP00401
(
show subtarget assignments
)
1
cloned
No
YPO2490
161486873
putative hemolysin
2531
Virulence Associated Factor
Phase 2: March 2008
1RWR
3.9%
Yersinia pestis
Viral functions
General
IDP91949
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007099
298255351
pneumococcal histidine triad protein E [...
1039
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2CS7
4.2%
Streptococcus pneumoniae
IDP92143
(
show subtarget assignments
)
8
selected
No
TGME49_068560
237832503
RAD2 endonuclease, putative [Toxoplasma ...
2004
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1UL1
4.4%
Toxoplasma gondii
IDP90110
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_015
68449089
ankyrin-like protein [Monkeypox virus]
660
similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L
Community Requests
1N0Q
4.4%
Monkeypox virus
IDP00167
(
show subtarget assignments
)
8
in_pdb
3FZY
Yes
VC1451
4455065
rtxA
RTX toxin RtxA
4545
Virulence
Community Requests
3EEB
4.6%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00181
(
show subtarget assignments
)
1
soluble
No
YPO0363
16120698
-
putative membrane transport protein
1119
Similar to Essential SALTY
Phase 1: October 2007
2OAU
5%
Yersinia pestis
DNA metabolism
DNA replication, recombination, and repair
IDP05321
(
show subtarget assignments
)
1
cloned
No
CD1857
126699466
putative conjugative transposon cell wal...
720
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2K1G
5%
Clostridium difficile
Unknown function: General
IDP90111
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_017
68449091
ankyrin-like protein [Monkeypox virus]
630
similar to VACV-COP-C9L, MPXV-ZAI96-D9L
Community Requests
3NOC
5.1%
Monkeypox virus
IDP91924
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007441
298255419
pneumococcal histidine triad protein B [...
574
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2CS7
5.1%
Streptococcus pneumoniae
IDP90146
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_193
68449265
ankyrin-like protein [Monkeypox virus]
789
similar to VACV-COP-B20R, MPXV-ZAI96-B17R
Community Requests
1MJ0
5.2%
Monkeypox virus
IDP91804
(
show subtarget assignments
)
8
selected
No
ZP_04523236
237510521
putative polyketide synthase PksL (PKS) ...
4567
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2HG4
5.4%
Burkholderia pseudomallei
IDP90180
(
show subtarget assignments
)
8
cloned
No
AAM13474.1
20153013
CPXV027 CDS
CPXV027 protein
632
ankyrin-like protein
Community Requests
3NOC
5.4%
Cowpox virus
conserved hypothetical proteins
0
IDP91805
(
show subtarget assignments
)
8
selected
No
GBP346_B0724
235002726
putative polyketide synthase PksL (PKS) ...
4567
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2HG4
5.4%
Burkholderia pseudomallei
IDP91981
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000172
298254015
serine protease [Streptococcus pneumonia...
2143
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3AFG
5.5%
Streptococcus pneumoniae
IDP05068
(
show subtarget assignments
)
1
soluble
No
CD2735
126700350
cell surface protein [Clostridium diffic...
475
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KQ8
5.5%
Clostridium difficile
Cell envelope: Other
IDP90199
(
show subtarget assignments
)
8
cloned
No
AAM13650.1
20153189
CPXV211 CDS
CPXV211 protein
574
ankyrin-like protein
Community Requests
3F6Q
5.6%
Cowpox virus
conserved hypothetical proteins
0
IDP00502
(
show subtarget assignments
)
1
selected
No
YPO2045
16122284
putative hemolysin
1576
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
5.6%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91806
(
show subtarget assignments
)
8
selected
No
ZP_04520447
237507732
putative polyketide synthase PksJ (PKS) ...
5053
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2VSQ
5.6%
Burkholderia pseudomallei
IDP90302
(
show subtarget assignments
)
0
work_stopped
No
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP91490
(
show subtarget assignments
)
8
expressed
No
VP1695
28898469
putative type III export protein PscD [V...
433
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
4A0E
5.8%
Vibrio parahaemolyticus
IDP05105
(
show subtarget assignments
)
1
cloned
No
CD1374
126698975
hypothetical protein CD1374 [Clostridium...
1743
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4D9S
5.9%
Clostridium difficile
Regulatory functions: Other
IDP05329
(
show subtarget assignments
)
1
soluble
No
BA_0815
30254405
purple acid phosphatase/fibronectin doma...
819
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2HY1
6%
Bacillus anthracis
Unknown function: General
IDP05668
(
show subtarget assignments
)
1
soluble
No
lmo0576
16802619
-
hypothetical protein lmo0576 [Listeria m...
487
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
6%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP04043
(
show subtarget assignments
)
1
soluble
No
VCA0565
15601324
sensor histidine kinase [Vibrio cholerae...
499
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1BXD
6%
Vibrio cholerae
Regulatory functions
Other
IDP90218
(
show subtarget assignments
)
8
soluble
No
MYXV_gp151
9633783
m148R
m148R
675
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
2J8S
6.1%
Myxoma virus
host range factor
0
IDP05555
(
show subtarget assignments
)
1
cloned
No
lmo1413
16803453
-
peptidoglycan binding protein [Listeria ...
439
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KVZ
6.2%
Listeria monocytogenes
Cell envelope: Other
IDP90308
(
show subtarget assignments
)
8
cloned
No
CT_700
3329154
hypothetical protein [Chlamydia trachoma...
441
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1NA0
6.3%
Chlamydia trachomatis
IDP91488
(
show subtarget assignments
)
8
cloned
No
VP1696
28898470
putative type III secretion protein YscC...
632
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2Y9K
6.3%
Vibrio parahaemolyticus
IDP04163
(
show subtarget assignments
)
1
expressed
No
VC1349
15641361
sensory box sensor histidine kinase/resp...
1331
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
6.5%
Vibrio cholerae
Regulatory functions
Other
IDP04166
(
show subtarget assignments
)
1
cloned
No
VC1653
15641658
sensory box sensor histidine kinase/resp...
1146
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
6.6%
Vibrio cholerae
Regulatory functions
Other
IDP04495
(
show subtarget assignments
)
1
soluble
No
VC0622
15640642
sensory box sensor histidine kinase/resp...
1177
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
6.6%
Vibrio cholerae
Regulatory functions
Other
IDP91543
(
show subtarget assignments
)
8
selected
No
TGME49_057080
237831315
cAMP-specific 3',5'-cyclic phosphodieste...
1691
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3ECM
6.6%
Toxoplasma gondii
IDP01670
(
show subtarget assignments
)
1
cloned
No
GBAA0156
47525414
hypothetical protein GBAA0156 [Bacillus ...
496
Conserved;
Phase 3: June 2008
2KQ1
6.7%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP05697
(
show subtarget assignments
)
1
soluble
No
lmo2178
16804217
-
peptidoglycan binding protein [Listeria ...
1599
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
6.9%
Listeria monocytogenes
Regulatory functions: Other
IDP04434
(
show subtarget assignments
)
1
cloned
No
YPCD1.52
16082740
yscC
outer membrane secretin precursor [Yersi...
607
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2Y9K
6.9%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91733
(
show subtarget assignments
)
8
selected
No
P88946_HHV8
0
449
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DLL
6.9%
Human herpesvirus
IDP91674
(
show subtarget assignments
)
8
selected
No
CGA1_HELPY
0
1147
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IEC
6.9%
Helicobacter pylori
IDP92129
(
show subtarget assignments
)
8
selected
No
TGME49_007990
237840609
ftsJ-like methyltransferase domain-conta...
981
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1EIZ
6.9%
Toxoplasma gondii
IDP00484
(
show subtarget assignments
)
1
cloned
No
YPO1417
16121697
putative iron-sulfur binding protein
370
Conserved Gene / Pathway
Phase 2: March 2008
2PIA
7%
Yersinia pestis
Energy metabolism
Electron transport
IDP91755
(
show subtarget assignments
)
8
selected
No
TXD11_HUMAN
0
958
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2B5E
7%
Homo sapiens
IDP05762
(
show subtarget assignments
)
1
soluble
No
lmo2119
16804158
-
hypothetical protein lmo2119 [Listeria m...
453
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KXY
7.1%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP01908
(
show subtarget assignments
)
1
cloned
No
STM1392
16764742
ssrA
sensor kinase [Salmonella typhimurium LT...
920
Conserved; Drug target functions
Phase 3: June 2008
2C2A
7.1%
Salmonella enterica
Energy metabolism
Anaerobic
IDP05436
(
show subtarget assignments
)
1
soluble
No
lmo2085
16804124
-
peptidoglycan binding protein [Listeria ...
562
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3IRP
7.1%
Listeria monocytogenes
Regulatory functions: Other
IDP92058
(
show subtarget assignments
)
8
selected
No
ACN59873
224590780
prex
plastid replication-repair enzyme [Toxop...
2579
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1D8Y
7.2%
Toxoplasma gondii
IDP91416
(
show subtarget assignments
)
8
cloned
No
VV1_0692
27364149
RNA polymerase factor sigma-54 [Vibrio v...
487
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2AHQ
7.2%
Vibrio vulnificus
IDP91696
(
show subtarget assignments
)
8
selected
No
NP_002283
119703755
LAMB2
laminin subunit beta-2 precursor [Homo s...
1798
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
7.3%
Homo sapiens
IDP02312
(
show subtarget assignments
)
1
expressed
No
GBAA2190
47778017
FtsK/SpoIIIE family protein [Bacillus an...
1342
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2IUT
7.4%
Bacillus anthracis
Cellular processes
Cell division
IDP05182
(
show subtarget assignments
)
1
soluble
No
BA_4984
30259476
gerHA
spore germination protein GerHA [Bacillu...
747
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3FBY
7.5%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP00797
(
show subtarget assignments
)
1
expressed
No
SACOL1250
57285989
chromosome segregation SMC protein, puta...
1188
Conserved Gene / Pathway
Phase 2: March 2008
1W1W
7.5%
Staphylococcus aureus
Cellular processes
Cell division
IDP05567
(
show subtarget assignments
)
1
soluble
No
lmo2576
16804614
-
pepdidoglycan bound protein [Listeria mo...
1530
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
7.5%
Listeria monocytogenes
Cell envelope: Other
IDP91758
(
show subtarget assignments
)
8
selected
No
VWF_HUMAN
0
2813
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SQ0
7.5%
Homo sapiens
IDP02799
(
show subtarget assignments
)
1
cloned
No
GBAA4787
47778326
hypothetical protein GBAA4787 [Bacillus ...
885
Conserved;
Phase 3: June 2008
3SIK
7.6%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP05536
(
show subtarget assignments
)
1
cloned
No
CD3145
126700762
putative serine-aspartate-rich surface a...
1190
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1YO8
7.6%
Clostridium difficile
Unknown function: General
IDP01952
(
show subtarget assignments
)
1
cloned
No
Cj1432c
15792750
putative sugar transferase [Campylobacte...
1031
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
2IV7
7.7%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04484
(
show subtarget assignments
)
1
purified
No
YPO3381
115349009
barA
two-component regulatory protein [Yersin...
930
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
7.8%
Yersinia pestis
Regulatory functions
Other
IDP00590
(
show subtarget assignments
)
1
cloned
No
YPO1078
16121379
mltD
predicted membrane-bound lytic murein tr...
475
Drug Target Function
Phase 2: March 2008
1E0G
7.8%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05132
(
show subtarget assignments
)
1
cloned
No
CD0262
126697834
flhB
bifunctional flagellar biosynthesis prot...
604
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2JLH
7.9%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP02181
(
show subtarget assignments
)
1
cloned
No
YPO0256
16120593
two-component sensor/regulator [Yersinia...
939
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
2C2A
8%
Yersinia pestis
Regulatory functions
Other
IDP04543
(
show subtarget assignments
)
1
expressed
No
VC2453
9657030
sensor histidine kinase/response regulat...
927
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
8.1%
Vibrio cholerae
Regulatory functions
Other
IDP05196
(
show subtarget assignments
)
1
cloned
No
CD0961
126698545
putative phage cell wall hydrolase [Clos...
656
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3H41
8.1%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP05353
(
show subtarget assignments
)
1
cloned
No
CD2903
126700520
putative phage cell wall hydrolase [Clos...
656
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3H41
8.1%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP05745
(
show subtarget assignments
)
1
expressed
No
CD2787
126700403
cwp84
cell surface protein (putative cell surf...
803
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1FH0
8.2%
Clostridium difficile
Cell envelope: Other
IDP92075
(
show subtarget assignments
)
8
selected
No
TGME49_095690
237844421
ubiquinone/menaquinone biosynthesis meth...
392
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1XXL
8.2%
Toxoplasma gondii
IDP04036
(
show subtarget assignments
)
1
cloned
No
CPF_1970
110800938
smc
chromosome segregation protein SMC [Clos...
1185
conserved gene; putative drug target function;
Phase 4: April 2009
3AUX
8.2%
Clostridium perfringens
Cellular processes
Cell division
IDP05657
(
show subtarget assignments
)
1
cloned
No
lmo0175
16802221
-
peptidoglycan binding protein [Listeria ...
415
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
8.2%
Listeria monocytogenes
Unclassified: Role category not yet assigned
IDP90176
(
show subtarget assignments
)
8
expressed
No
AAM13470.1
20153009
CPXV023 CDS
CPXV023 protein
242
zinc-finger-like protein
Community Requests
2ECW
8.3%
Cowpox virus
host defense modulator
0
IDP90108
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_013
68449087
bifunctional zinc finger-like protein/E3...
242
similar to VARV BEN68-zinc finger-like protein
Community Requests
2ECW
8.3%
Monkeypox virus
IDP04463
(
show subtarget assignments
)
1
cloned
No
YPO1959
115347684
narR
nitrate/nitrite sensor protein [Yersinia...
593
conserved gene; putative drug target function;
Phase 4: April 2009
3EZH
8.4%
Yersinia pestis
Energy metabolism
Anaerobic
IDP05346
(
show subtarget assignments
)
1
soluble
No
CD1036
126698620
cell surface protein (putative N-acetylm...
677
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3NE8
8.4%
Clostridium difficile
Cell envelope: Other
IDP04381
(
show subtarget assignments
)
8
selected
No
CAC05791
12329060
unnamed protein product [Shigella flexne...
296
Shigella effector protein
Community Requests
3MKL
8.4%
Shigella flexneri
IDP00948
(
show subtarget assignments
)
1
expressed
No
STM1060
16764419
putative iron-sulfur protein
369
Conserved Gene / Pathway
Phase 2: March 2008
1ROE
8.4%
Salmonella enterica
Energy metabolism
Electron transport
IDP05754
(
show subtarget assignments
)
1
cloned
No
lmo0627
16802669
-
pepdidoglycan bound protein [Listeria mo...
1582
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1D2P
8.4%
Listeria monocytogenes
Energy metabolism: Electron transport
IDP05107
(
show subtarget assignments
)
1
soluble
No
CD1751
126699358
cell surface protein (putative cell surf...
795
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1VSN
8.4%
Clostridium difficile
Cell envelope: Other
IDP02817
(
show subtarget assignments
)
1
cloned
No
lmo2185
16804224
hypothetical protein lmo2185 [Listeria m...
569
Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...
Phase 3: June 2008
2O6P
8.4%
Listeria monocytogenes
Unclassified
Role category not yet assigned
IDP91037
(
show subtarget assignments
)
8
cloned
No
SAHV_0560
156978891
sdrD
Ser-Asp rich fibrinogen-binding, bone si...
1385
virulence/pathogenesis /
Sdr family proteins are interesting cell surface proteins in Staphylococcus aure...
Community Requests
3IS1
8.5%
Staphylococcus aureus
IDP01168
(
show subtarget assignments
)
1
expressed
No
GBAA_pXO2_0084
47566748
capsule synthesis trans-acting positive ...
483
Virulence Associated Factor
Phase 2: March 2008
3SQN
8.5%
Bacillus anthracis
IDP90216
(
show subtarget assignments
)
8
expressed
No
MYXV_gp008
9633799
m005L
m005L, m5, M-T5
483
ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.
Community Requests
1N0R
8.5%
Myxoma virus
host range factor, host defense modulator
0
IDP90292
(
show subtarget assignments
)
8
cloned
No
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP02758
(
show subtarget assignments
)
1
cloned
No
GBAA_pXO2_0073
47566739
signal peptidase i, (pxo2-59) [Bacillus ...
183
Drug target motif;
Phase 3: June 2008
1B12
8.7%
Bacillus anthracis
N/A
N/A
IDP91694
(
show subtarget assignments
)
8
selected
No
NP_001989
51873055
FBLN2
fibulin-2 isoform b precursor [Homo sapi...
1184
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1N7D
8.7%
Homo sapiens
IDP90345
(
show subtarget assignments
)
8
cloned
No
CT157
15604876
phospholipase D endonuclease superfamily...
404
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1BYR
8.9%
Chlamydia trachomatis
IDP91681
(
show subtarget assignments
)
8
selected
No
LAMC3_HUMAN
0
1587
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
8.9%
Homo sapiens
IDP92552
(
show subtarget assignments
)
8
selected
No
NP_071445
11545912
NOD2
nucleotide-binding oligomerization domai...
1040
innate immunity /
JUSTIFICATION:NOD2 is a cytoplasmic protein containing 1040 residus and three fu...
Community Requests
1DFJ
9%
Homo sapiens
IDP00514
(
show subtarget assignments
)
1
selected
No
YPO3721
16123859
hemolysin
1635
Conserved Gene / Pathway
Phase 2: March 2008
3FY3
9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP04712
(
show subtarget assignments
)
1
cloned
No
YPO0514
115346324
putative OmpA-family membrane protein [Y...
536
virulence factor; putative drug target function;
Phase 4: April 2009
2L26
9%
Yersinia pestis
Cell envelope
Other
IDP05663
(
show subtarget assignments
)
1
selected
No
lmo0333
16802378
-
hypothetical protein lmo0333 [Listeria m...
1778
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1ZIW
9.1%
Listeria monocytogenes
Cellular processes: Pathogenesis
IDP91552
(
show subtarget assignments
)
8
expressed
No
BAB38718
13364773
ECs5295
hypothetical protein [Escherichia coli O...
735
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3DU1
9.1%
Escherichia coli
IDP00753
(
show subtarget assignments
)
1
cloned
No
SACOL0052
57286607
glycosyl transferase, group 1 family pro...
503
Conserved Gene / Pathway
Phase 2: March 2008
2F9F
9.1%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP92116
(
show subtarget assignments
)
8
selected
No
TGME49_060680
237831887
DNA primase small subunit, putative [Tox...
509
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1G71
9.2%
Toxoplasma gondii
IDP92027
(
show subtarget assignments
)
8
selected
No
TGME49_017580
237844055
DNA-directed RNA polymerases III, 39 kDa...
325
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2DK5
9.2%
Toxoplasma gondii
IDP91749
(
show subtarget assignments
)
8
selected
No
Q9DUM3_HHV8
0
1036
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3H0G
9.3%
Human herpesvirus
IDP04356
(
show subtarget assignments
)
1
cloned
No
YPO0509
115346318
hypothetical protein [Yersinia pestis CO...
540
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2XT4
9.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
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