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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91185
(
show subtarget assignments
)
8
cloned
No
AAC46367
2352978
477
virulence/pathogenesis /
FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...
Community Requests
1NY5
31.9%
Vibrio cholerae
IDP90941
(
show subtarget assignments
)
8
expressed
No
NMPDR 214092.1.peg.4098
246
Predicted Essential
Community Requests
2PB0
66.3%
Yersinia pestis
IDP90097
(
show subtarget assignments
)
8
cloned
No
ZZZ_0013
104
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90968
(
show subtarget assignments
)
8
selected
No
427
Planet Biotechnology company is currently developing an anthrax anti-toxin with ...
Community Requests
1HZH
62.3%
synthetic construct
IDP91064
(
show subtarget assignments
)
1
cloned
No
y2422
21959284
144
other biological interest /
Identified in a mutant screen
Community Requests
Yersinia pestis
IDP90939
(
show subtarget assignments
)
8
expressed
No
NMPDR 243277.1.peg.3882
198
Predicted Essential
Community Requests
2AU3
34.3%
Vibrio cholerae
IDP90089
(
show subtarget assignments
)
8
expressed
No
ZZZ_0005
600
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90938
(
show subtarget assignments
)
8
cloned
No
NMPDR 243277.1.peg.3917
218
Predicted Essential
Community Requests
2JGV
22.5%
Vibrio cholerae
IDP90098
(
show subtarget assignments
)
8
purified
No
ZZZ_0014
196
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
3U66
19.4%
Escherichia coli
IDP90094
(
show subtarget assignments
)
8
cloned
No
ZZZ_0010
358
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90090
(
show subtarget assignments
)
8
expressed
No
ZZZ_0006
310
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90092
(
show subtarget assignments
)
8
purified
No
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90093
(
show subtarget assignments
)
8
expressed
No
ZZZ_0009
99
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP90086
(
show subtarget assignments
)
8
expressed
No
ZZZ_0002
492
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90100
(
show subtarget assignments
)
8
expressed
No
ZZZ_0016
849
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
1QVR
36.8%
Escherichia coli
IDP90095
(
show subtarget assignments
)
8
soluble
No
ZZZ_0011
184
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90096
(
show subtarget assignments
)
8
expressed
No
ZZZ_0012
476
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90099
(
show subtarget assignments
)
8
cloned
No
ZZZ_0015
1137
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP00300
(
show subtarget assignments
)
1
cloned
No
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP90612
(
show subtarget assignments
)
8
soluble
No
NMPDR 243277.1.peg.3916
281
Predicted Essential
Community Requests
1COZ
17.1%
Vibrio cholerae
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90087
(
show subtarget assignments
)
8
cloned
No
ZZZ_0003
168
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90554
(
show subtarget assignments
)
8
selected
No
NMPDR 243277.1.peg.3911
163
Predicted Essential
Community Requests
1DD8
81%
Vibrio cholerae
IDP90940
(
show subtarget assignments
)
8
cloned
No
NMPDR 243277.1.peg.3912
278
Predicted Essential
Community Requests
1DD8
61.9%
Vibrio cholerae
IDP90088
(
show subtarget assignments
)
8
soluble
No
ZZZ_0004
140
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91379
(
show subtarget assignments
)
8
purified
No
VV1_1473
27364857
Zn-dependent protease with chaperone fun...
331
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3C37
17.2%
Vibrio vulnificus
IDP91931
(
show subtarget assignments
)
8
expressed
No
SpneCM_010100007426
298255416
zinc transport system ATP-binding protei...
234
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3FVQ
30.8%
Streptococcus pneumoniae
IDP01947
(
show subtarget assignments
)
1
soluble
No
STM1656
16765000
zntB
zinc transporter [Salmonella typhimurium...
327
Conserved; Drug target functions
Phase 3: June 2008
3NVO
80.1%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP01826
(
show subtarget assignments
)
1
in_pdb
3LAY
No
STM4172
16767426
zraP
zinc resistance protein [Salmonella typh...
151
Conserved; Drug target functions
Phase 3: June 2008
3LAY
100%
Salmonella enterica
Unknown function
General
IDP05649
(
show subtarget assignments
)
1
expressed
No
Cj0464
6967934
recG
zinc protease-like protein [Campylobacte...
607
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1GM5
28.8%
Campylobacter jejuni
DNA metabolism: DNA replication, recombination, and repair
IDP01136
(
show subtarget assignments
)
1
soluble
No
BA_3942
30258453
zinc protease, insulinase family
413
Drug Target Function
Phase 2: March 2008
3HDI
63%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01428
(
show subtarget assignments
)
1
purified
No
VC1709
15641713
zinc protease, insulinase family
922
Drug Target Function
Phase 2: March 2008
3CWW
19%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02484
(
show subtarget assignments
)
1
expressed
No
GBAA3922
47529214
zinc protease [Bacillus anthracis str. '...
428
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HDI
24.1%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02657
(
show subtarget assignments
)
1
cloned
No
lmo0203
16802249
mpl
Zinc metalloproteinase precursor [Lister...
510
Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...
Phase 3: June 2008
1BQB
27.3%
Listeria monocytogenes
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91906
(
show subtarget assignments
)
8
selected
No
SpneCMD_010100004020
298229824
zinc metalloprotease ZmpB [Streptococcus...
1902
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP00872
(
show subtarget assignments
)
1
cloned
No
STM0138
16763528
yacG
zinc-binding protein
63
Conserved Gene / Pathway
Phase 2: March 2008
1LV3
85.7%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP91968
(
show subtarget assignments
)
8
in_crystallization_trials
No
SpneCM_010100007436
298255418
zinc-binding lipoprotein AdcA [Streptoco...
501
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2O1E
29.5%
Streptococcus pneumoniae
IDP01444
(
show subtarget assignments
)
1
soluble
No
VC2081
15642081
zinc ABC transporter, periplasmic zinc-b...
297
Conserved Gene / Pathway
Phase 2: March 2008
2OGW
44.3%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01321
(
show subtarget assignments
)
1
purified
No
VC2082
15642082
zinc ABC transporter, ATP-binding protei...
262
Conserved Gene / Pathway
Phase 2: March 2008
3FVQ
28.2%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01153
(
show subtarget assignments
)
1
cloned
No
BA_5712
30260159
yycI protein
280
Conserved Gene / Pathway
Phase 2: March 2008
2O3O
28.2%
Bacillus anthracis
Cellular processes
Cell division
IDP00451
(
show subtarget assignments
)
1
expressed
No
YPCD1.20
16082709
yopT
Yop targeted effector
322
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Surface structures
IDP91895
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000537
298254086
YitT family protein [Streptococcus pneum...
313
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91597
(
show subtarget assignments
)
8
cloned
No
BAA24464
2804528
YfiX [Bacillus subtilis]
610
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91588
(
show subtarget assignments
)
8
cloned
No
BAA24463
2804527
YfiW [Bacillus subtilis]
258
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP04093
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1907
218929023
irp5
yersiniabactin siderophore biosynthetic ...
525
drug target; virulence factor; conserved gene; putative drug target function;...
Phase 4: April 2009
1MD9
47.8%
Yersinia pestis
Cellular processes
Cell division
IDP00253
(
show subtarget assignments
)
1
in_crystallization_trials
No
YFVgp1
9627245
Yellow fever virus Envelope protein
399
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
1P58
43.8%
Yellow fever
IDP02023
(
show subtarget assignments
)
1
soluble
No
STM3661
16766946
xylA
xylose isomerase [Salmonella typhimurium...
440
Conserved; Drug target functions
Phase 3: June 2008
1A0D
51.6%
Salmonella enterica
Energy metabolism
Sugars
IDP91849
(
show subtarget assignments
)
8
selected
No
STER_1358
116628108
XRE family transcriptional regulator [St...
286
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91855
(
show subtarget assignments
)
8
selected
No
STER_1299
116628056
XRE family transcriptional regulator [St...
291
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91847
(
show subtarget assignments
)
8
selected
No
STER_0934
116627734
XRE family transcriptional regulator [St...
285
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91848
(
show subtarget assignments
)
8
selected
No
STER_1530
116628259
XRE family transcriptional regulator [St...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
IDP91851
(
show subtarget assignments
)
8
selected
No
SDEG_1013
251782424
XRE family transcriptional regulator [St...
295
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus dysgalactiae
IDP04120
(
show subtarget assignments
)
1
soluble
No
BAS1475
49184492
xanthine phosphoribosyltransferase [Baci...
197
Proposed to be essential proteins
Phase 4: April 2009
1Y0B
65%
Bacillus anthracis
IDP04009
(
show subtarget assignments
)
1
cloned
No
VC2277
15642275
xanthine-guanine phosphoribosyltransfera...
154
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1A95
68.8%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Salvage of nucleosides and nucleotides
IDP01115
(
show subtarget assignments
)
1
in_pdb
3IG4
No
BA_1901
30256561
xaa-pro aminopeptidase, putative
427
Drug Target Function
Phase 2: March 2008
3IG4
100%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP91181
(
show subtarget assignments
)
8
cloned
No
CT578
3329020
wall surface anchor family protein [Chla...
487
virulence/pathogenesis /
Targets that are in a network of interactions with CT670 and CT671. These protei...
Community Requests
Chlamydia trachomatis
IDP05717
(
show subtarget assignments
)
1
cloned
No
BA_1098
30254828
wall-associated domain protein [Bacillus...
178
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP91705
(
show subtarget assignments
)
8
selected
No
NP_004879
4757818
ATP6V1G1
V-type proton ATPase subunit G 1 [Homo s...
118
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2K88
27.1%
Homo sapiens
IDP91809
(
show subtarget assignments
)
8
selected
No
ZEBOVgp2
10313992
VP35
VP35 [Zaire ebolavirus]
340
Justification: Zaire ebolavirus belongs to the Filoviruses genus, on which struc...
Community Requests
3KS4
40.3%
Zaire ebolavirus
IDP00858
(
show subtarget assignments
)
1
purified
No
STM1342
16764693
btuD
vitamin B12-transporter ATPase
249
Conserved Gene / Pathway
Phase 2: March 2008
1L7V
80.3%
Salmonella enterica
Transport and binding proteins
Other
IDP02153
(
show subtarget assignments
)
1
expressed
No
CBU_0884
29541475
bipA
virulence regulator BipA [Coxiella burne...
602
Conserved; Drug target functions
Phase 3: June 2008
3E3X
34.6%
Coxiella burnetii
Cellular processes
Pathogenesis
IDP04699
(
show subtarget assignments
)
1
expressed
No
YPCD1.53
16082741
yscD
virulence protein [Yersinia pestis CO92]...
419
virulence factor; conserved gene;
Phase 4: April 2009
4A0E
28.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP01854
(
show subtarget assignments
)
1
expressed
No
STM1246
16764600
pagC
virulence membrane protein PAGC precurso...
185
Conserved; Drug target functions
Phase 3: June 2008
1ORM
34.1%
Salmonella enterica
Cellular processes
Pathogenesis
IDP90946
(
show subtarget assignments
)
8
cloned
No
BP1878
33592926
bvgA
virulence factors transcription regulato...
209
BvgA is the transcriptional activator for all known virulence genes in the human...
Community Requests
3C3W
31.6%
Bordetella pertussis
IDP91594
(
show subtarget assignments
)
8
cloned
No
BAS1375
49184392
-
virulence factor MprF
861
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus anthracis
IDP90117
(
show subtarget assignments
)
8
in_crystallization_trials
No
MPXV_ZAI1979_005_027
68449101
virokine protein [Monkeypox virus]
117
similar to VACV-COP-N1L, MPXV-ZAI96-P1L
Community Requests
2I39
89.7%
Monkeypox virus
IDP04537
(
show subtarget assignments
)
8
selected
No
CAC05780
12329049
virF
VirF, member of the AraC family of trans...
262
Shigella effector protein
Community Requests
3GBG
26.3%
Shigella flexneri
IDP91679
(
show subtarget assignments
)
8
selected
No
HHV8GK18_gp64
139472850
vIRF-3
vIRF-3 [Human herpesvirus 8]
566
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Human herpesvirus
IDP91056
(
show subtarget assignments
)
8
expressed
No
AAA42941
323448
viral polyprotein [Dengue virus 2]
3391
potential drug target /
A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...
Community Requests
2J7U
15.1%
Dengue virus
IDP91717
(
show subtarget assignments
)
8
selected
No
NP_054706
7669550
VCL
vinculin isoform meta-VCL [Homo sapiens]...
1134
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1TR2
94%
Homo sapiens
IDP91933
(
show subtarget assignments
)
8
selected
No
SpneCM_010100001964
298254365
VicX protein [Streptococcus pneumoniae s...
269
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP00132
(
show subtarget assignments
)
1
purified
No
VC_0288
9654699
VC0288
Vibrio cholerae O1 biovar eltor str. N16...
618
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2GP4
53.9%
Vibrio cholerae
Energy metabolism
Entner-Doudoroff
IDP00137
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC_0959
9655418
VC0959
Vibrio cholerae O1 biovar eltor str. N16...
291
Virulence
Phase 1: October 2007
3NQR
29.6%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00114
(
show subtarget assignments
)
1
purified
No
GVCV52ORF0478
9654887
Vibrio cholerae O1 biovar eltor str. N16...
345
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3JVU
65.8%
Vibrio cholerae
Cell envelope
Surface structures
IDP00134
(
show subtarget assignments
)
1
purified
No
VC_2250
9656811
VC2250
Vibrio cholerae O1 biovar eltor str. N16...
351
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3EH0
63%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01750
(
show subtarget assignments
)
1
in_pdb
3RJ4
3UXJ
3RZQ
3RZP
3S19
3UXV
3RJB
No
VC_0902
9655358
Vibrio cholerae O1 biovar eltor str. N16...
287
DRUG TARGET HOMOLOG
Phase 3: June 2008
3BP1
100%
Vibrio cholerae
N/A
N/A
IDP00133
(
show subtarget assignments
)
1
purified
No
VC_2095
9656644
VC2095
Vibrio cholerae O1 biovar eltor str. N16...
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
2FUV
70.3%
Vibrio cholerae
Energy metabolism
Sugars
IDP00147
(
show subtarget assignments
)
1
expressed
No
VC0780
15640799
vibD
vibriobactin synthase component D
261
Virulence
Phase 1: October 2007
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01401
(
show subtarget assignments
)
1
purified
No
VC0773
15640792
vibriobactin-specific isochorismate synt...
395
Drug Target Function
Phase 2: March 2008
3OS6
44.2%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01399
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0771
15640790
vibriobactin-specific isochorismatase
293
Conserved Gene / Pathway
Phase 2: March 2008
2FQ1
44.4%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01400
(
show subtarget assignments
)
1
expressed
No
VC0772
15640791
vibriobactin-specific 2,3-dihydroxybenzo...
543
Conserved Gene / Pathway
Phase 2: March 2008
1MD9
51.6%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00145
(
show subtarget assignments
)
1
expressed
No
VC0777
15640796
viuD
vibriobactin and enterobactin ABC transp...
350
Virulence
Phase 1: October 2007
2NQ2
30.6%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00146
(
show subtarget assignments
)
1
soluble
No
VC0778
15640797
viuG
vibriobactin and enterobactin ABC transp...
358
Virulence
Phase 1: October 2007
2QI9
28.2%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00148
(
show subtarget assignments
)
1
soluble
No
VCA0227
15600996
vctP
vibriobactin and enterobactin ABC transp...
333
Virulence
Phase 1: October 2007
3GFV
30.3%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00144
(
show subtarget assignments
)
1
soluble
No
VC0776
15640795
viuP
vibriobactin and enterobactin ABC transp...
325
Virulence
Phase 1: October 2007
3R5S
91.4%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00143
(
show subtarget assignments
)
1
soluble
No
VC0779
15640798
viuC
vibriobactin and enterobactin ABC transp...
279
Virulence
Phase 1: October 2007
1B0U
29%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP00149
(
show subtarget assignments
)
1
expressed
No
VCA0230
15600999
vctC
vibriobactin and enterobactin ABC transp...
254
Virulence
Phase 1: October 2007
2D62
28%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP90178
(
show subtarget assignments
)
8
purified
No
AAM13472.1
20153011
VHR1
VHR1 or CPXV025 protein
668
ankyrin-like protein, CP77
Community Requests
1N11
10%
Cowpox virus
host range protein
0
IDP91786
(
show subtarget assignments
)
8
selected
No
AAA98349
153077
vgh
vgh [Staphylococcus aureus]
299
drug resistance /
Hydrolase inactivating the B components of virginiamycin-like antibiotics
Community Requests
2Z2N
99.3%
Staphylococcus aureus
IDP91044
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFA0002
110556113
vanY
vanY [Enterococcus faecalis]
303
drug resistance /
A carboxypeptidase thought to be involved in breakdown of normal cell wall
Community Requests
Enterococcus faecalis
IDP91775
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAL27443
16612080
vanXYE
VanXYE [Enterococcus faecalis]
193
drug resistance /
D,D-dipeptidase/D,D-carboxypeptidase
Community Requests
Enterococcus faecalis
IDP92247
(
show subtarget assignments
)
8
selected
No
ABA71730
77380198
vanWG
VanWG [Enterococcus faecalis]
281
drug resistance /
Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...
Community Requests
Enterococcus faecalis
IDP91799
(
show subtarget assignments
)
8
selected
No
AAL27442
16612079
vanE
VanE [Enterococcus faecalis]
352
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1E4E
41.5%
Enterococcus faecalis
IDP91791
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAA24789
148330
vanH
vancomycin resistance protein [Enterococ...
322
drug resistance /
Dehydrogenase that reduces pyruvate to D-lactate, which is required to produce a...
Community Requests
3KB6
35.7%
Enterococcus faecium
IDP91878
(
show subtarget assignments
)
8
selected
No
pVEF1_014
121633839
vanB
VanA protein [Enterococcus faecium]
343
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
1E4E
98.8%
Enterococcus faecium
IDP90598
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3443
16123591
valS
valyl-tRNA synthetase [Yersinia pestis C...
965
Predicted Essential
Community Requests
1GAX
40.5%
Yersinia pestis
IDP90658
(
show subtarget assignments
)
8
cloned
No
VC2503
15642499
valS
valyl-tRNA synthetase [Vibrio cholerae O...
953
Predicted Essential
Community Requests
1GAX
38.8%
Vibrio cholerae
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