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Targets
Filter Targets:
Selection Phase:
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Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90098
(
show subtarget assignments
)
8
purified
No
ZZZ_0014
196
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
3U66
19.4%
Escherichia coli
IDP90940
(
show subtarget assignments
)
8
cloned
No
NMPDR 243277.1.peg.3912
278
Predicted Essential
Community Requests
1DD8
61.9%
Vibrio cholerae
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP90100
(
show subtarget assignments
)
8
expressed
No
ZZZ_0016
849
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
1QVR
36.8%
Escherichia coli
IDP90092
(
show subtarget assignments
)
8
purified
No
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90099
(
show subtarget assignments
)
8
cloned
No
ZZZ_0015
1137
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP90095
(
show subtarget assignments
)
8
soluble
No
ZZZ_0011
184
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90093
(
show subtarget assignments
)
8
expressed
No
ZZZ_0009
99
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90554
(
show subtarget assignments
)
8
selected
No
NMPDR 243277.1.peg.3911
163
Predicted Essential
Community Requests
1DD8
81%
Vibrio cholerae
IDP90096
(
show subtarget assignments
)
8
expressed
No
ZZZ_0012
476
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90612
(
show subtarget assignments
)
8
soluble
No
NMPDR 243277.1.peg.3916
281
Predicted Essential
Community Requests
1COZ
17.1%
Vibrio cholerae
IDP90094
(
show subtarget assignments
)
8
cloned
No
ZZZ_0010
358
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP00300
(
show subtarget assignments
)
1
cloned
No
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP90939
(
show subtarget assignments
)
8
expressed
No
NMPDR 243277.1.peg.3882
198
Predicted Essential
Community Requests
2AU3
34.3%
Vibrio cholerae
IDP90968
(
show subtarget assignments
)
8
selected
No
427
Planet Biotechnology company is currently developing an anthrax anti-toxin with ...
Community Requests
1HZH
62.3%
synthetic construct
IDP90097
(
show subtarget assignments
)
8
cloned
No
ZZZ_0013
104
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91369
(
show subtarget assignments
)
8
in_pdb
4DB3
No
VV1_2570
326424042
N-acetyl-D-glucosamine kinase [Vibrio vu...
303
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
4DB3
100%
Vibrio vulnificus
IDP91185
(
show subtarget assignments
)
8
cloned
No
AAC46367
2352978
477
virulence/pathogenesis /
FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...
Community Requests
1NY5
31.9%
Vibrio cholerae
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90087
(
show subtarget assignments
)
8
cloned
No
ZZZ_0003
168
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90086
(
show subtarget assignments
)
8
expressed
No
ZZZ_0002
492
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90941
(
show subtarget assignments
)
8
expressed
No
NMPDR 214092.1.peg.4098
246
Predicted Essential
Community Requests
2PB0
66.3%
Yersinia pestis
IDP90938
(
show subtarget assignments
)
8
cloned
No
NMPDR 243277.1.peg.3917
218
Predicted Essential
Community Requests
2JGV
22.5%
Vibrio cholerae
IDP90089
(
show subtarget assignments
)
8
expressed
No
ZZZ_0005
600
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90088
(
show subtarget assignments
)
8
soluble
No
ZZZ_0004
140
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90090
(
show subtarget assignments
)
8
expressed
No
ZZZ_0006
310
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91064
(
show subtarget assignments
)
1
cloned
No
y2422
21959284
144
other biological interest /
Identified in a mutant screen
Community Requests
Yersinia pestis
IDP00301
(
show subtarget assignments
)
1
expressed
No
CBU_0983
291
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
3NVT
10.7%
Coxiella burnetii
IDP01826
(
show subtarget assignments
)
1
in_pdb
3LAY
No
STM4172
16767426
zraP
zinc resistance protein [Salmonella typh...
151
Conserved; Drug target functions
Phase 3: June 2008
3LAY
100%
Salmonella enterica
Unknown function
General
IDP02366
(
show subtarget assignments
)
1
expressed
No
YPO2061
16122300
znuA
high-affinity zinc transporter periplasm...
318
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...
Phase 3: June 2008
2OGW
63.5%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP01947
(
show subtarget assignments
)
1
soluble
No
STM1656
16765000
zntB
zinc transporter [Salmonella typhimurium...
327
Conserved; Drug target functions
Phase 3: June 2008
3NVO
80.1%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP04694
(
show subtarget assignments
)
1
soluble
No
GBAA5714
47531051
yycG
sensory box histidine kinase YycG [Bacil...
613
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
15.3%
Bacillus anthracis
Regulatory functions
Protein interactions
IDP91199
(
show subtarget assignments
)
1
cloned
No
BSU40540
16081106
yybR
putative transcriptional regulator [Baci...
125
other biological interest /
YybR belongs to the MarR/DUF24 family of transcriptional regulators that are hig...
Community Requests
4A5M
100%
Bacillus subtilis
IDP04194
(
show subtarget assignments
)
1
cloned
No
CPF_2444
110799147
yyaC
putative sporulation protein YyaC [Clost...
176
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP04065
(
show subtarget assignments
)
1
cloned
No
CPF_2985
110800289
yyaC
putative sporulation protein YyaC [Clost...
196
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP04097
(
show subtarget assignments
)
1
cloned
No
CPF_2217
110801384
yunB
sporulation protein YunB [Clostridium pe...
229
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP01255
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_5132
30259616
yugI
general stress protein 13
114
Conserved Gene / Pathway
Phase 2: March 2008
2K4K
53.3%
Bacillus anthracis
Cellular processes
Adaptations to atypical conditions
IDP00081
(
show subtarget assignments
)
1
in_crystallization_trials
No
NT01ST5473
16422973
ytfP
putative cytoplasmic protein
114
Essential
Phase 1: October 2007
1XHS
92.1%
Salmonella enterica
Unknown function
General
IDP01622
(
show subtarget assignments
)
1
cloned
No
STM4396
16767642
ytfB
putative cell envelope opacity-associate...
211
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP04289
(
show subtarget assignments
)
1
expressed
No
YPCD1.35c
16082723
yscY
hypothetical protein YPCD1.35c [Yersinia...
114
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP91183
(
show subtarget assignments
)
8
in_pdb
3T7Y
No
CT091
15604810
yscU
type III secretion system protein [Chlam...
360
virulence/pathogenesis /
Targets that are in a network of interactions with CT670 and CT671. These protei...
Community Requests
3T7Y
26.7%
Chlamydia trachomatis
IDP04698
(
show subtarget assignments
)
1
cloned
No
YPCD1.46
16082734
yscT
needle complex export protein [Yersinia ...
261
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP04100
(
show subtarget assignments
)
1
cloned
No
YPCD1.45
16082733
yscS
needle complex export protein [Yersinia ...
88
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00450
(
show subtarget assignments
)
1
cloned
No
YPCD1.40
16082728
yscN
type III secretion system ATPase
439
Virulence Associated Factor
Phase 2: March 2008
2DPY
42.8%
Yersinia pestis
Energy metabolism
ATP-proton motive force interconversion
IDP00413
(
show subtarget assignments
)
1
soluble
No
YPCD1.60
16082748
yscK
type III secretion apparatus component
209
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04699
(
show subtarget assignments
)
1
expressed
No
YPCD1.53
16082741
yscD
virulence protein [Yersinia pestis CO92]...
419
virulence factor; conserved gene;
Phase 4: April 2009
4A0E
28.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP04434
(
show subtarget assignments
)
1
cloned
No
YPCD1.52
16082740
yscC
outer membrane secretin precursor [Yersi...
607
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2Y9K
6.9%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP01031
(
show subtarget assignments
)
0
work_stopped
No
STM3497
16766785
yrfH
ribosome-associated heat shock protein H...
133
Conserved Gene / Pathway
Phase 2: March 2008
1DM9
95.5%
Salmonella enterica
Protein synthesis
Other
IDP01056
(
show subtarget assignments
)
1
in_pdb
3R3R
Yes
STM3399
16766688
yrdA
putative ferripyochelin-binding protein ...
184
Conserved Gene / Pathway
Phase 2: March 2008
3R3R
100%
Salmonella enterica
Central intermediary metabolism
Other
IDP00075
(
show subtarget assignments
)
0
work_stopped
No
NTL01ST3174
16421824
yraO
putative phosphoheptose isomerase
196
Phase 1: October 2007
2YVA
98%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP02226
(
show subtarget assignments
)
1
crystallized
No
GBAA0164
47525422
yqjI
6-phosphogluconate dehydrogenase [Bacill...
469
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2W8Z
72.3%
Bacillus anthracis
Energy metabolism
Pentose phosphate pathway
IDP02080
(
show subtarget assignments
)
1
in_pdb
3KZ2
3IH1
No
GBAA2350
47527645
yqiQ
carboxyvinyl-carboxyphosphonate phosphor...
302
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3IH1
100%
Bacillus anthracis
Central intermediary metabolism
Other
IDP91770
(
show subtarget assignments
)
8
soluble
No
STM3096
16766397
yqgE
hypothetical protein
187
virulence/pathogenesis /
This protein has been shown to be involved in the regulation of Salmonella Typhi...
Community Requests
2AJ2
48.4%
Salmonella enterica
IDP90222
(
show subtarget assignments
)
1
in_pdb
3H2Y
No
BAS4233
49187229
YqeH
GTP-binding protein YqeH, possibly invol...
368
YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess in...
January 2009
3H2Y
100%
Bacillus anthracis
IDP90385
(
show subtarget assignments
)
8
cloned
No
CT_392
3328818
yprS
hypothetical protein [Chlamydia trachoma...
377
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00449
(
show subtarget assignments
)
1
cloned
No
YPO2706
16122910
yplA
phospholipase A
320
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP01833
(
show subtarget assignments
)
1
cloned
No
STM2476
16765796
ypfG
putative periplasmic protein [Salmonella...
347
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01747
(
show subtarget assignments
)
1
soluble
No
STM2407
16765733
ypeC
putative periplasmic protein [Salmonella...
108
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP04436
(
show subtarget assignments
)
1
expressed
No
YPCD1.97c
5832512
YPCD1.97c
putative transposase [Yersinia pestis CO...
308
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04353
(
show subtarget assignments
)
1
expressed
No
YPCD1.96c
5832511
YPCD1.96c
putative transposase [Yersinia pestis CO...
143
drug target; virulence factor; conserved gene; putative drug target function;...
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP04315
(
show subtarget assignments
)
1
expressed
No
YPCD1.93
5832508
YPCD1.93
putative transposase [Yersinia pestis CO...
88
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP04047
(
show subtarget assignments
)
1
cloned
No
YPCD1.92
5832507
YPCD1.92
hypothetical protein YPCD1.92 [Yersinia ...
109
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04314
(
show subtarget assignments
)
1
purified
No
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP04038
(
show subtarget assignments
)
1
expressed
No
YPCD1.65
5832485
YPCD1.65
putative transposase [Yersinia pestis CO...
102
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04354
(
show subtarget assignments
)
1
expressed
No
YPCD1.44
5832464
YPCD1.44
putative Yop secretion membrane protein ...
217
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cell envelope
Surface structures
IDP04273
(
show subtarget assignments
)
1
cloned
No
YPCD1.23
5832444
YPCD1.23
hypothetical protein YPCD1.23 [Yersinia ...
139
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04118
(
show subtarget assignments
)
1
cloned
No
YPCD1.22c
5832443
YPCD1.22c
hypothetical protein YPCD1.22c [Yersinia...
129
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04041
(
show subtarget assignments
)
1
cloned
No
YPCD1.16c
5832438
YPCD1.16c
hypothetical protein YPCD1.16c [Yersinia...
107
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP04696
(
show subtarget assignments
)
1
cloned
No
YPCD1.15c
5832437
YPCD1.15c
hypothetical protein YPCD1.15c [Yersinia...
152
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP04078
(
show subtarget assignments
)
1
expressed
No
YPCD1.09c
5832432
YPCD1.09c
hypothetical protein YPCD1.09c [Yersinia...
91
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
29.7%
Yersinia pestis
Hypothetical proteins
Conserved
IDP04288
(
show subtarget assignments
)
1
expressed
No
YPCD1.08c
5832431
YPCD1.08c
hypothetical protein YPCD1.08c [Yersinia...
99
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
28.3%
Yersinia pestis
IDP04061
(
show subtarget assignments
)
1
cloned
No
YPCD1.07
5832430
YPCD1.07
hypothetical protein YPCD1.07 [Yersinia ...
98
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04695
(
show subtarget assignments
)
1
expressed
No
YPCD1.01
5832424
YPCD1.01
putative transposase [Yersinia pestis CO...
340
virulence factor; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP00451
(
show subtarget assignments
)
1
expressed
No
YPCD1.20
16082709
yopT
Yop targeted effector
322
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Surface structures
IDP00447
(
show subtarget assignments
)
1
cloned
No
YPCD1.71c
16082759
yopJ
targeted effector protein
288
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP04697
(
show subtarget assignments
)
1
soluble
No
YPCD1.29c
16082717
yopB
secreted effector protein [Yersinia pest...
401
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP01621
(
show subtarget assignments
)
1
cloned
No
STM1984
16765321
yodD
putative cytoplasmic protein [Salmonella...
75
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01949
(
show subtarget assignments
)
0
work_stopped
No
STM1822
16765163
yoaB
putative translation initiation inhibito...
114
Conserved; Drug target functions
Phase 3: June 2008
3GTZ
99.1%
Salmonella enterica
Unknown function
General
IDP00099
(
show subtarget assignments
)
0
work_stopped
No
NT02SF1983
30041448
ynhD
putative ATP-binding component of a tran...
248
Conserved; CD; Drug target functions
Phase 1: October 2007
2D3W
99.6%
Shigella flexneri
Transport and binding proteins
Unknown substrate
IDP00875
(
show subtarget assignments
)
1
in_pdb
3G0M
No
STM1374
16764724
ynhA
cysteine desufuration protein SufE
138
Conserved Gene / Pathway
Phase 2: March 2008
3G0M
100%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP01530
(
show subtarget assignments
)
1
in_pdb
3EFV
3ETF
No
STM1524
16764869
yneI
putative succinate-semialdehyde dehydrog...
462
It is an essential gene in Salmonella which is important in energy metabolism.
Phase 3: June 2008
3EFV
100%
Salmonella enterica
IDP00080
(
show subtarget assignments
)
1
expressed
No
NT01ST5073
16422645
yneC
putative inner membrane protein
109
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3QMQ
70.6%
Salmonella enterica
Cell envelope
Other
IDP00086
(
show subtarget assignments
)
1
in_pdb
3DR6
3DR8
No
NT01ST1973
16420114
yncA
putative acyltransferase
171
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3DR6
100%
Salmonella enterica
Transport and binding proteins
Other
IDP90944
(
show subtarget assignments
)
8
cloned
No
STM1121
16764478
ymdF
putative cytoplasmic protein [Salmonella...
55
This is a protein with experimental and computational evidence for being secrete...
Community Requests
Salmonella enterica
IDP00943
(
show subtarget assignments
)
1
crystallized
No
STM0862
16764224
yliJ
putative glutathione S-transferase
208
Conserved Gene / Pathway
Phase 2: March 2008
4ECI
30.8%
Salmonella enterica
Cellular processes
Detoxification
IDP00130
(
show subtarget assignments
)
1
in_crystallization_trials
No
NT01ST5659
16767805
yjjV
putative deoxyribonuclease YjjV
257
Virulence
Phase 1: October 2007
1ZZM
76.7%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP01667
(
show subtarget assignments
)
1
expressed
No
FTT1782c
56708774
yjjK
putative ABC transporter ATP-binding pro...
559
Conserved; Drug target functions
Phase 3: June 2008
1YQT
27.3%
Francisella tularensis
Transport and binding proteins
Unknown substrate
IDP91819
(
show subtarget assignments
)
8
expressed
No
b4307
1790761
yjhQ
KpLE2 phage-like element; predicted acet...
181
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
Escherichia coli
IDP00870
(
show subtarget assignments
)
1
cloned
No
STM4470
16767715
yjgD
hypothetical protein STM4470
138
Conserved Gene / Pathway
Phase 2: March 2008
1NXI
54.3%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP02050
(
show subtarget assignments
)
1
soluble
No
STM4365
16767611
yjeT
putative inner membrane protein [Salmone...
65
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP01679
(
show subtarget assignments
)
1
cloned
No
FTT0738
56707853
yjeF
carbohydrate kinase family protein (YjeF...
514
Conserved; Drug target functions
Phase 3: June 2008
2AX3
28%
Francisella tularensis
Energy metabolism
Sugars
IDP02117
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM4356
16767602
yjeF
hypothetical protein STM4356 [Salmonella...
515
Conserved; Drug target functions
Phase 3: June 2008
2AX3
31.3%
Salmonella enterica
Unknown function
General
IDP01693
(
show subtarget assignments
)
1
in_pdb
3G1Z
No
STM4344
16767593
yjeA
lysyl-tRNA synthetase [Salmonella typhim...
325
DRUG TARGET HOMOLOG
Phase 3: June 2008
3G1Z
100%
Salmonella enterica
N/A
N/A
IDP91769
(
show subtarget assignments
)
8
soluble
No
YPTB1890
51596222
yjcK
ribosomal-protein-alanine acetyltransfer...
185
drug resistance; innate immunity /
Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...
Community Requests
3R95
24.3%
Yersinia pseudotuberculosis
IDP00868
(
show subtarget assignments
)
1
expressed
No
STM4171
16767425
yjaH
putative inner membrane protein
230
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Cell envelope
Other
IDP91021
(
show subtarget assignments
)
8
cloned
No
y2872
22126749
yiuR
putative outer membrane receptor [Yersin...
665
other biological interest /
putative iron-binding TonB-dependent outer membrane receptor
Community Requests
2HDF
38%
Yersinia pestis
IDP01072
(
show subtarget assignments
)
1
cloned
No
STM4003
16767268
yihI
hypothetical protein STM4003
171
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
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