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Targets
Filter Targets:
Selection Phase:
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Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00254
(
show subtarget assignments
)
1
in_pdb
3P54
Yes
13272205
Japanese encephalitis virus Envelope pro...
406
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
98.3%
Japanese encephalitis
IDP90968
(
show subtarget assignments
)
8
selected
No
427
Planet Biotechnology company is currently developing an anthrax anti-toxin with ...
Community Requests
1HZH
62.3%
synthetic construct
IDP90949
(
show subtarget assignments
)
8
purified
No
ZZZ_0019
20986512
MAPK14
mitogen-activated protein kinase 14 isof...
360
Drug Target
Community Requests
1A9U
100%
Homo sapiens
IDP90950
(
show subtarget assignments
)
8
soluble
No
ZZZ_0018
51094326
MAPK-1
mitogen-activated protein kinase 1
532
Drug Target Homolog
Community Requests
3OHT
30.1%
Toxoplasma gondii
IDP04210
(
show subtarget assignments
)
1
expressed
No
ZZZ_0017
243
Effector protein
Phase 4: April 2009
2KXC
18.5%
Escherichia coli
IDP90100
(
show subtarget assignments
)
8
expressed
No
ZZZ_0016
849
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
1QVR
36.8%
Escherichia coli
IDP90099
(
show subtarget assignments
)
8
cloned
No
ZZZ_0015
1137
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90098
(
show subtarget assignments
)
8
purified
No
ZZZ_0014
196
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
3U66
19.4%
Escherichia coli
IDP90097
(
show subtarget assignments
)
8
cloned
No
ZZZ_0013
104
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90096
(
show subtarget assignments
)
8
expressed
No
ZZZ_0012
476
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90095
(
show subtarget assignments
)
8
soluble
No
ZZZ_0011
184
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90094
(
show subtarget assignments
)
8
cloned
No
ZZZ_0010
358
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90093
(
show subtarget assignments
)
8
expressed
No
ZZZ_0009
99
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90092
(
show subtarget assignments
)
8
purified
No
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90091
(
show subtarget assignments
)
8
expressed
No
ZZZ_0007
660
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
2P5Z
15.6%
Escherichia coli
IDP90090
(
show subtarget assignments
)
8
expressed
No
ZZZ_0006
310
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90089
(
show subtarget assignments
)
8
expressed
No
ZZZ_0005
600
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90088
(
show subtarget assignments
)
8
soluble
No
ZZZ_0004
140
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90087
(
show subtarget assignments
)
8
cloned
No
ZZZ_0003
168
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90086
(
show subtarget assignments
)
8
expressed
No
ZZZ_0002
492
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP90085
(
show subtarget assignments
)
8
purified
No
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91864
(
show subtarget assignments
)
8
selected
No
ZP_08398653
332522401
transcriptional regulator, Cro/CI family...
301
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus porcinus
IDP91804
(
show subtarget assignments
)
8
selected
No
ZP_04523236
237510521
putative polyketide synthase PksL (PKS) ...
4567
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2HG4
5.4%
Burkholderia pseudomallei
IDP91806
(
show subtarget assignments
)
8
selected
No
ZP_04520447
237507732
putative polyketide synthase PksJ (PKS) ...
5053
virulence/pathogenesis /
Emerging evidence suggests that natural products from pathogenic organisms are i...
Community Requests
2VSQ
5.6%
Burkholderia pseudomallei
IDP90084
(
show subtarget assignments
)
8
soluble
No
ZP_01795673
145640079
hypothetical protein CGSHiII_00674 [Haem...
148
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
28.4%
Haemophilus influenzae
IDP90083
(
show subtarget assignments
)
8
cloned
No
ZP_01795671
145640077
hypothetical protein CGSHiII_00664 [Haem...
219
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
35.6%
Haemophilus influenzae
IDP91809
(
show subtarget assignments
)
8
selected
No
ZEBOVgp2
10313992
VP35
VP35 [Zaire ebolavirus]
340
Justification: Zaire ebolavirus belongs to the Filoviruses genus, on which struc...
Community Requests
3KS4
40.3%
Zaire ebolavirus
IDP05118
(
show subtarget assignments
)
1
cloned
No
Z5902
12519310
putative helicase [Escherichia coli O157...
704
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1PJR
12.8%
Escherichia coli
Protein synthesis: Ribosomal proteins: synthesis and modification
IDP90250
(
show subtarget assignments
)
8
expressed
No
Z5515
15804553
argE
acetylornithine deacetylase [Escherichia...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
26.9%
Escherichia coli
IDP04209
(
show subtarget assignments
)
1
soluble
No
Z5142
15804250
hypothetical protein Z5142 [Escherichia ...
398
Effector protein
Phase 4: April 2009
3PCR
89.7%
Escherichia coli
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP05332
(
show subtarget assignments
)
1
soluble
No
Z4866
12518154
putative beta-ketoacyl-ACP synthase [Esc...
409
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
4EWG
59.7%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05085
(
show subtarget assignments
)
1
soluble
No
Z4863
12518151
putative 3-oxoacyl-[ACP] synthase [Esche...
389
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3KZU
31.9%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05084
(
show subtarget assignments
)
1
in_crystallization_trials
No
Z4803
12518085
putative ATP-dependent DNA helicase (tog...
202
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1OYW
33.7%
Escherichia coli
DNA metabolism: DNA replication, recombination, and repair
IDP90007
(
show subtarget assignments
)
8
cloned
No
Z4378
12517596
qseC
quorum sensing Escherichia coli regulato...
449
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3JZ3
47%
Escherichia coli
IDP90005
(
show subtarget assignments
)
8
soluble
No
Z4377
12517595
qseB
quorum sensing Escherichia coli regulato...
219
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3Q9S
41.1%
Escherichia coli
IDP05345
(
show subtarget assignments
)
1
soluble
No
Z3383
12516442
pbpG
penicillin-binding protein 7 [Escherichi...
313
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1XP4
25.9%
Escherichia coli
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05772
(
show subtarget assignments
)
1
cloned
No
Z3171
12516188
dacD
penicillin binding protein 6b [Escherich...
425
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1NZO
40.7%
Escherichia coli
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05344
(
show subtarget assignments
)
1
in_crystallization_trials
No
Z1549
12514420
putative beta-ketoacyl-[acyl carrier pro...
852
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1J3N
18.2%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05343
(
show subtarget assignments
)
1
soluble
No
Z1544
12514412
putative acyl-carrier protein synthase [...
122
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1FTE
36.1%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05304
(
show subtarget assignments
)
1
cloned
No
Z1313
12514147
helD
DNA helicase IV [Escherichia coli O157:H...
715
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2IS1
14.3%
Escherichia coli
DNA metabolism: DNA replication, recombination, and repair
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP05585
(
show subtarget assignments
)
1
soluble
No
Z0801
12513558
ybeK
putative tRNA synthetase [Escherichia co...
311
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1YOE
99.4%
Escherichia coli
Protein synthesis: tRNA aminoacylation
IDP05771
(
show subtarget assignments
)
1
cloned
No
Z0339
12513053
alpha replication protein of prophage CP...
777
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1KA8
9.5%
Escherichia coli
Mobile and extrachromosomal element functions: Prophage functions
IDP91769
(
show subtarget assignments
)
8
soluble
No
YPTB1890
51596222
yjcK
ribosomal-protein-alanine acetyltransfer...
185
drug resistance; innate immunity /
Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...
Community Requests
3R95
24.3%
Yersinia pseudotuberculosis
IDP91765
(
show subtarget assignments
)
8
purified
No
YPTB1885
51596217
ThiF family protein [Yersinia pseudotube...
577
other biological interest; innate immunity /
Yersinia pseudotuberculosis MccB-like (MccB homologs) - E.coli MccB catalyses ad...
Community Requests
3H5A
12.1%
Yersinia pseudotuberculosis
IDP01823
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPPCP1.05c
16082684
pst
pesticin [Yersinia pestis CO92]
357
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...
Phase 3: June 2008
4AQN
100%
Yersinia pestis
Regulatory functions
Other
IDP00427
(
show subtarget assignments
)
1
in_pdb
3FWW
No
YPO4119
16124227
glmU
bifunctional N-acetylglucosamine-1-phosp...
456
Drug Target Function
Phase 2: March 2008
3FWW
100%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90731
(
show subtarget assignments
)
8
soluble
No
YPO4101
16124209
rnpA
ribonuclease P [Yersinia pestis CO92]
119
Predicted Essential
Community Requests
2LJP
89.1%
Yersinia pestis
IDP90819
(
show subtarget assignments
)
8
purified
No
YPO4094
16124203
gyrB
DNA gyrase subunit B [Yersinia pestis CO...
804
Predicted Essential
Community Requests
1EI1
43.7%
Yersinia pestis
IDP04493
(
show subtarget assignments
)
1
cloned
No
YPO4089
115349677
pyridoxal-phosphate dependent enzyme [Ye...
320
putative drug target function;
Phase 4: April 2009
3HMK
36.6%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP90610
(
show subtarget assignments
)
8
soluble
No
YPO4071
16124184
glyS
glycyl-tRNA synthetase subunit beta [Yer...
689
Predicted Essential
Community Requests
Yersinia pestis
IDP00543
(
show subtarget assignments
)
1
purified
No
YPO4057
16124173
fdoH
formate dehydrogenase-O, iron-sulfur sub...
323
Conserved Gene / Pathway
Phase 2: March 2008
1KQF
70.9%
Yersinia pestis
Energy metabolism
Anaerobic
IDP00405
(
show subtarget assignments
)
1
purified
No
YPO4025
16124148
putative iron ABC transporter, ATP-bindi...
252
Conserved Gene / Pathway
Phase 2: March 2008
3FVQ
31.3%
Yersinia pestis
Transport and binding proteins
Unknown substrate
IDP00176
(
show subtarget assignments
)
1
cloned
No
YPO4024
16124147
-
putative iron transport permease
335
Virulence
Phase 1: October 2007
2QI9
23.9%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00516
(
show subtarget assignments
)
1
purified
No
YPO4022
16124145
putative iron transport protein
317
Conserved Gene / Pathway
Phase 2: March 2008
3GFV
34.4%
Yersinia pestis
Transport and binding proteins
Unknown substrate
IDP04154
(
show subtarget assignments
)
1
cloned
No
YPO4017
218931008
hutU
urocanate hydratase [Yersinia pestis CO9...
563
conserved gene; putative drug target function;
Phase 4: April 2009
1UWL
86.3%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00569
(
show subtarget assignments
)
1
purified
No
YPO4016
16124139
hutH
histidine ammonia-lyase
510
Drug Target Function
Phase 2: March 2008
1GK2
77.5%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00536
(
show subtarget assignments
)
1
purified
No
YPO4003
16124128
dppA
periplasmic dipeptide transport protein ...
535
Virulence Associated Factor
Phase 2: March 2008
1DPP
81.5%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00573
(
show subtarget assignments
)
1
in_pdb
3GO9
No
YPO3991
16124118
putative insulinase family protease
499
Drug Target Function
Phase 2: March 2008
3GO9
98.6%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04153
(
show subtarget assignments
)
1
cloned
No
YPO3975
218930970
opdA
oligopeptidase A [Yersinia pestis CO92]
680
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1S4B
30.7%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04409
(
show subtarget assignments
)
1
cloned
No
YPO3965
115349572
putative hybrid two-component system reg...
851
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
9.3%
Yersinia pestis
Regulatory functions
Other
IDP02650
(
show subtarget assignments
)
1
expressed
No
YPO3962
16124090
sugar-binding transport protein [Yersini...
314
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
2IOY
34.7%
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP90899
(
show subtarget assignments
)
8
soluble
No
YPO3949
16124077
asd
aspartate-semialdehyde dehydrogenase [Ye...
367
Predicted Essential
Community Requests
1BRM
83.4%
Yersinia pestis
IDP00553
(
show subtarget assignments
)
1
expressed
No
YPO3939
16124067
glgA
glycogen synthase
476
Drug Target Function
Phase 2: March 2008
2QZS
71.4%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP00226
(
show subtarget assignments
)
1
soluble
No
YPO3938
16124066
glgP
glycogen phosphorylase
815
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 1: October 2007
1EM6
49.9%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90247
(
show subtarget assignments
)
8
purified
No
YPO3928
115349537
argE
acetylornithine deacetylase [Yersinia pe...
389
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
26%
Yersinia pestis
IDP90617
(
show subtarget assignments
)
8
crystallized
No
YPO3927
16124057
argC
N-acetyl-gamma-glutamyl-phosphate reduct...
334
Predicted Essential
Community Requests
2G17
78.1%
Yersinia pestis
IDP00203
(
show subtarget assignments
)
1
in_pdb
3T7B
No
YPO3925
16124056
argB
acetylglutamate kinase
257
Virulence
Phase 1: October 2007
3T7B
100%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00537
(
show subtarget assignments
)
1
purified
No
YPO3924
16124055
argH
argininosuccinate lyase
457
Conserved Gene / Pathway
Phase 2: March 2008
1TJ7
88.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00515
(
show subtarget assignments
)
1
cloned
No
YPO3922
16124053
hemophore HasA
205
Virulence Associated Factor
Phase 2: March 2008
1B2V
29.8%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP04152
(
show subtarget assignments
)
1
cloned
No
YPO3919
218930919
HlyD family secretion protein [Yersinia ...
442
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00597
(
show subtarget assignments
)
1
purified
No
YPO3909
16124041
murI
glutamate racemase
287
Conserved Gene / Pathway
Phase 2: March 2008
2JFN
71.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02064
(
show subtarget assignments
)
1
cloned
No
YPO3878
16124011
putative fimbrial chaperone [Yersinia pe...
243
CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions
Phase 3: June 2008
3Q48
32.5%
Yersinia pestis
Protein fate
Protein folding and stabilization
IDP04151
(
show subtarget assignments
)
1
cloned
No
YPO3864
218930867
nfrC
UDP-N-acetylglucosamine 2-epimerase [Yer...
376
drug target; putative drug target function;
Phase 4: April 2009
1F6D
78.7%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00425
(
show subtarget assignments
)
1
purified
No
YPO3863
16123998
wecC
UDP-N-acetyl-D-mannosamine dehydrogenase...
420
Conserved Gene / Pathway
Phase 2: March 2008
3OJL
42.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90851
(
show subtarget assignments
)
8
purified
No
YPO3862
16123997
rffG
dTDP-D-glucose-4,6-dehydratase [Yersinia...
355
Predicted Essential
Community Requests
1BXK
82%
Yersinia pestis
IDP90675
(
show subtarget assignments
)
8
cloned
No
YPO3861
16123996
rffH
glucose-1-phosphate thymidylyltransferas...
293
Predicted Essential
Community Requests
1MC3
86.7%
Yersinia pestis
IDP00560
(
show subtarget assignments
)
1
soluble
No
YPO3852
16123987
hemY
putative protoheme IX biogenesis protein...
406
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Unknown function
General
IDP90867
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3850
16123985
hemD
uroporphyrinogen-III synthase [Yersinia ...
249
Predicted Essential
Community Requests
3MW8
33.7%
Yersinia pestis
IDP90777
(
show subtarget assignments
)
8
soluble
No
YPO3849
16123984
hemC
porphobilinogen deaminase [Yersinia pest...
313
Predicted Essential
Community Requests
1AH5
80.5%
Yersinia pestis
IDP00477
(
show subtarget assignments
)
1
purified
No
YPO3845
16123980
dapF
diaminopimelate epimerase
274
Conserved Gene / Pathway
Phase 2: March 2008
1GQZ
75.9%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP00445
(
show subtarget assignments
)
1
purified
No
YPO3843
16123978
xerC
site-specific tyrosine recombinase XerC ...
303
Conserved Gene / Pathway
Phase 2: March 2008
1A0P
35.6%
Yersinia pestis
DNA metabolism
DNA replication, recombination, and repair
IDP90755
(
show subtarget assignments
)
8
cloned
No
YPO3841
16123976
uvrD
DNA-dependent helicase II [Yersinia pest...
720
Predicted Essential
Community Requests
2IS1
83.3%
Yersinia pestis
IDP04492
(
show subtarget assignments
)
1
cloned
No
YPO3834
218930837
pldA
phospholipase A [Yersinia pestis CO92]
292
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
1FW2
69.2%
Yersinia pestis
Fatty acid and phospholipid metabolism
Degradation
IDP90873
(
show subtarget assignments
)
8
soluble
No
YPO3830
16123965
pldB
lysophospholipase L2 [Yersinia pestis CO...
337
Predicted Essential
Community Requests
Yersinia pestis
IDP01788
(
show subtarget assignments
)
1
crystallized
No
YPO3827
16123962
glpQ
glycerophosphodiester phosphodiesterase ...
371
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1YDY
71.7%
Yersinia pestis
Central intermediary metabolism
Other
IDP00549
(
show subtarget assignments
)
1
purified
No
YPO3814
16123948
ftsY
cell division protein
541
Conserved Gene / Pathway
Phase 2: March 2008
2YHS
63.7%
Yersinia pestis
Cellular processes
Cell division
IDP00547
(
show subtarget assignments
)
1
expressed
No
YPO3813
16123947
ftsE
cell division protein FtsE
222
Conserved Gene / Pathway
Phase 2: March 2008
3DHW
39.6%
Yersinia pestis
Cellular processes
Cell division
IDP00475
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3808
16123942
livK
branched-chain amino acid-binding protei...
371
Virulence Associated Factor
Phase 2: March 2008
1USG
71.7%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00586
(
show subtarget assignments
)
1
purified
No
YPO3789
16123923
metR
lysR-family transcriptional regulatory p...
317
Virulence Associated Factor
Phase 2: March 2008
1AL3
23.7%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP02472
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3785
16123919
hypothetical protein YPO3785 [Yersinia p...
276
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
1YWF
26.2%
Yersinia pestis
Energy metabolism
Sugars
IDP90893
(
show subtarget assignments
)
8
expressed
No
YPO3781
16123915
ubiE
ubiquinone/menaquinone biosynthesis meth...
251
Predicted Essential
Community Requests
2AVN
21.9%
Yersinia pestis
IDP90808
(
show subtarget assignments
)
8
selected
No
YPO3779
16123913
ubiB
putative ubiquinone biosynthesis protein...
543
Predicted Essential
Community Requests
Yersinia pestis
IDP90791
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3771
16123907
hemB
delta-aminolevulinic acid dehydratase [Y...
340
Predicted Essential
Community Requests
1B4K
66.8%
Yersinia pestis
IDP90802
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO3769
16123905
3-octaprenyl-4-hydroxybenzoate decarboxy...
498
Predicted Essential
Community Requests
2IDB
88.2%
Yersinia pestis
IDP00415
(
show subtarget assignments
)
1
expressed
No
YPO3767
16123903
fadA
3-ketoacyl-CoA thiolase
387
Virulence Associated Factor
Phase 2: March 2008
3GOA
79.8%
Yersinia pestis
Cellular processes
Detoxification
IDP00503
(
show subtarget assignments
)
1
purified
No
YPO3766
16123902
fadB
multifunctional fatty acid oxidation com...
729
Virulence Associated Factor
Phase 2: March 2008
1WDK
55.1%
Yersinia pestis
Cellular processes
Detoxification
IDP04491
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3765
218930769
pepQ
proline dipeptidase [Yersinia pestis CO9...
443
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3RVA
54.8%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP90863
(
show subtarget assignments
)
8
cloned
No
YPO3761
16123898
hemG
protoporphyrinogen oxidase [Yersinia pes...
177
Predicted Essential
Community Requests
Yersinia pestis
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