Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00850 (show subtarget assignments)	1	purified	No	SACOL2389	57285120		transcriptional regulatory protein DegU,...	217	Conserved Gene / Pathway	Phase 2: March 2008	1A04	31.3%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP02023 (show subtarget assignments)	1	soluble	No	STM3661	16766946	xylA	xylose isomerase [Salmonella typhimurium...	440	Conserved; Drug target functions	Phase 3: June 2008	1A0D	51.6%	Salmonella enterica	Energy metabolism	Sugars

IDP91466 (show subtarget assignments)	8	soluble	No	VV1_0078	27363563		site-specific recombinase XerC [Vibrio v...	234	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1A0P	20.1%	Vibrio vulnificus

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP00445 (show subtarget assignments)	1	purified	No	YPO3843	16123978	xerC	site-specific tyrosine recombinase XerC ...	303	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	35.6%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP05241 (show subtarget assignments)	1	cloned	No	lmo1955	16803994	-	hypothetical protein lmo1955 [Listeria m...	297	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	43.8%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP04653 (show subtarget assignments)	1	expressed	No	FTT1503	56708541	xerC	integrase/recombinase XerC [Francisella ...	292	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A0P	34.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00446 (show subtarget assignments)	1	purified	No	YPO0892	16121197	xerD	site-specific tyrosine recombinase XerD ...	299	Conserved Gene / Pathway	Phase 2: March 2008	1A0P	80.9%	Yersinia pestis	DNA metabolism	DNA replication, recombination, and repair

IDP05681 (show subtarget assignments)	1	cloned	No	lmo1277	16803317	codV	hypothetical protein lmo1277 [Listeria m...	300	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	35%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP00418 (show subtarget assignments)	1	crystallized	No	YPO0910	16121215	pepP	proline aminopeptidase P II	437	Drug Target Function	Phase 2: March 2008	1A16	81.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01514 (show subtarget assignments)	1	purified	No	VCA0518	15601278		fructose-specific PTS IIA/HPr components...	400	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	11.5%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00505 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1298	16121580	fruB	fructose-specific PTS IIA/HPr components...	377	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00885 (show subtarget assignments)	1	purified	No	STM2206	16765536	fruF	fructose-specific PTS IIA/HPr components...	376	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17.3%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00818 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2148	57286362		PTS system, mannitol-specific IIA compon...	144	Drug Target Function	Phase 2: March 2008	1A3A	34.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01118 (show subtarget assignments)	1	crystallized	No	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04388 (show subtarget assignments)	1	soluble	No	VC2751	15642744		adenosine deaminase [Vibrio cholerae O1 ...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A4L	32.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP92021 (show subtarget assignments)	8	selected	No	TGME49_005720	237837011		adenosine/AMP deaminase domain containin...	366	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1A4L	25.7%	Toxoplasma gondii

IDP90644 (show subtarget assignments)	8	in_crystallization_trials	No	STM1201	16764556	holB	DNA polymerase III subunit delta' [Salmo...	334	Predicted Essential	Community Requests	1A5T	79%	Salmonella enterica

IDP91261 (show subtarget assignments)	8	soluble	No	NT05BA0041	49176992		DNA polymerase III, delta prime subunit ...	327	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A5T	20.2%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP90607 (show subtarget assignments)	8	purified	No	VC2015	15642017		DNA polymerase III subunit delta' [Vibri...	324	Predicted Essential	Community Requests	1A5T	33%	Vibrio cholerae

IDP90924 (show subtarget assignments)	8	purified	No	YPO1606	16121874	holB	DNA polymerase III subunit delta' [Yersi...	340	Predicted Essential	Community Requests	1A5T	51.5%	Yersinia pestis

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP90548 (show subtarget assignments)	8	cloned	No	Cj0960c	15792289	rnpA	ribonuclease P protein component [Campyl...	108	Predicted Essential	Community Requests	1A6F	27.9%	Campylobacter jejuni

IDP01812 (show subtarget assignments)	1	cloned	No	FTT1764c	56708759		ferredoxin [Francisella tularensis subsp...	107	Conserved; Drug target functions	Phase 3: June 2008	1A6L	64.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP91274 (show subtarget assignments)	8	soluble	No	NT05BA4272	49181014		acetyl-CoA carboxylase, biotin carboxyl ...	164	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A6X	23.2%	Bacillus anthracis	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90751 (show subtarget assignments)	8	cloned	No	Cj1291c	15792614	accB	acetyl-CoA carboxylase biotin carboxyl c...	151	Predicted Essential	Community Requests	1A6X	27.2%	Campylobacter jejuni

IDP90589 (show subtarget assignments)	8	soluble	No	VC0296	15640324		acetyl-CoA carboxylase [Vibrio cholerae ...	196	Predicted Essential	Community Requests	1A6X	37.2%	Vibrio cholerae

IDP01749 (show subtarget assignments)	1	purified	No	Cj1224	15792548		putative iron-binding protein [Campyloba...	199	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1A7D	18.1%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01891 (show subtarget assignments)	1	purified	No	STM3464	16766752	prkB	putative phosphoribulokinase [Salmonella...	289	Conserved; Drug target functions	Phase 3: June 2008	1A7J	50.5%	Salmonella enterica	Energy metabolism	Sugars

IDP01471 (show subtarget assignments)	1	purified	No	VC2613	15642608		phosphoribulokinase	289	Conserved Gene / Pathway	Phase 2: March 2008	1A7J	51.6%	Vibrio cholerae	Energy metabolism	Sugars

IDP02096 (show subtarget assignments)	1	cloned	No	YPO0178	16120519	prk	phosphoribulokinase 1 [Yersinia pestis C...	289	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1A7J	49.5%	Yersinia pestis	Energy metabolism	Photosynthesis

IDP04687 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04009 (show subtarget assignments)	1	cloned	No	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP00421 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1331	16121613	potF	putrescine transporter subunit: periplas...	369	Virulence Associated Factor	Phase 2: March 2008	1A99	82.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02388 (show subtarget assignments)	1	soluble	No	YPO1407	16121687		hypothetical protein YPO1407 [Yersinia p...	618	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1A9U	25.6%	Yersinia pestis	Cell envelope	Other

IDP90949 (show subtarget assignments)	8	purified	No	ZZZ_0019	20986512	MAPK14	mitogen-activated protein kinase 14 isof...	360	Drug Target	Community Requests	1A9U	100%	Homo sapiens

IDP90274 (show subtarget assignments)	8	selected	No	TGME49_015260	211968509		carbamoyl phosphate synthetase II [Toxop...	1699	Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...	Community Requests	1A9X	27.1%	Toxoplasma gondii

IDP00574 (show subtarget assignments)	1	cloned	No	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00192 (show subtarget assignments)	1	cloned	No	YPO0947	16121251	-	putative virulence determinant	3110	Virulence	Phase 1: October 2007	1AF0	2.9%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00989 (show subtarget assignments)	1	purified	No	STM2183	16765513	cdd	cytidine deaminase	294	Conserved Gene / Pathway	Phase 2: March 2008	1AF2	87.4%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01459 (show subtarget assignments)	1	soluble	No	VC2420	161581987		flavodoxin	172	Conserved Gene / Pathway	Phase 2: March 2008	1AG9	45.3%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01446 (show subtarget assignments)	1	in_crystallization_trials	No	VC2099	15642099		flavodoxin FldA	175	Conserved Gene / Pathway	Phase 2: March 2008	1AG9	75.4%	Vibrio cholerae	Energy metabolism	Electron transport

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP90777 (show subtarget assignments)	8	soluble	No	YPO3849	16123984	hemC	porphobilinogen deaminase [Yersinia pest...	313	Predicted Essential	Community Requests	1AH5	80.5%	Yersinia pestis

IDP90701 (show subtarget assignments)	8	soluble	No	Cj0545	15791906	hemC	porphobilinogen deaminase [Campylobacter...	307	Predicted Essential	Community Requests	1AH5	47.9%	Campylobacter jejuni

IDP01663 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90821 (show subtarget assignments)	8	soluble	No	VC0120	15640152	hemC	porphobilinogen deaminase [Vibrio choler...	317	Predicted Essential	Community Requests	1AH5	73.5%	Vibrio cholerae

IDP02205 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0259	56707415	hemC	hydroxymethylbilane synthase (porphobili...	300	Conserved; Drug target functions	Phase 3: June 2008	1AH5	54.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01069 (show subtarget assignments)	1	soluble	No	STM3938	16767209	hemC	porphobilinogen deaminase	318	Conserved Gene / Pathway	Phase 2: March 2008	1AH5	87.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02257 (show subtarget assignments)	1	expressed	No	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02620 (show subtarget assignments)	1	cloned	No	lmo0205	16802251	plcB	phospholipase C [Listeria monocytogenes ...	289	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...	Phase 3: June 2008	1AH7	32.5%	Listeria monocytogenes	Cellular processes	Toxin production and resistance

IDP02148 (show subtarget assignments)	1	cloned	No	GBAA0133	47525389	infA	translation initiation factor IF-1 [Baci...	72	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AH9	72.2%	Bacillus anthracis	Protein synthesis	Translation factors

IDP90643 (show subtarget assignments)	8	soluble	No	VC0638	15640658		dihydropteroate synthase [Vibrio cholera...	278	Predicted Essential	Community Requests	1AJ0	55.8%	Vibrio cholerae

IDP90642 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0585	15791945	folP	dihydropteroate synthase [Campylobacter ...	380	Predicted Essential	Community Requests	1AJ0	25.8%	Campylobacter jejuni

IDP90287 (show subtarget assignments)	8	purified	No	TGME49_021210	211967615		18 kDa cyclophilin [Toxoplasma gondii ME...	179	Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...	Community Requests	1AK4	53.6%	Toxoplasma gondii

IDP01228 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4283	30258785		peptidyl-prolyl cis-trans isomerase, cyc...	145	Conserved Gene / Pathway	Phase 2: March 2008	1AK4	42.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02287 (show subtarget assignments)	1	purified	No	FTT1161	56708232	adk	adenylate kinase [Francisella tularensis...	218	Drug Target	Phase 3: June 2008	1AKE	56.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00480 (show subtarget assignments)	1	soluble	No	YPO3118	16123283	adk	adenylate kinase	214	Conserved Gene / Pathway	Phase 2: March 2008	1AKE	87.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP91820 (show subtarget assignments)	8	soluble	No	b0474	1786680	adk	adenylate kinase [Escherichia coli str. ...	214	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1AKE	100%	Escherichia coli

IDP04500 (show subtarget assignments)	1	crystallized	No	VC0986	15641001	adk	adenylate kinase [Vibrio cholerae O1 bio...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AKE	73.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00519 (show subtarget assignments)	1	cloned	No	YPO3446	16123594	argI	ornithine carbamoyltransferase subunit I...	335	Conserved Gene / Pathway	Phase 2: March 2008	1AKM	79.1%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00586 (show subtarget assignments)	1	purified	No	YPO3789	16123923	metR	lysR-family transcriptional regulatory p...	317	Virulence Associated Factor	Phase 2: March 2008	1AL3	23.7%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02111 (show subtarget assignments)	1	in_crystallization_trials	No	STM3694	16766979	lldD	L-lactate dehydrogenase [Salmonella typh...	396	Conserved; Drug target functions	Phase 3: June 2008	1AL7	32.6%	Salmonella enterica	Energy metabolism	Aerobic

IDP05504 (show subtarget assignments)	1	purified	No	CD0869	126698446	modA	putative molybdenum ABC transporter,subs...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	31.9%	Clostridium difficile	Transport and binding proteins: Anions

IDP05678 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1041	16803081	-	hypothetical protein lmo1041 [Listeria m...	256	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	30.9%	Listeria monocytogenes	Transport and binding proteins: Cations and iron carrying compounds

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP04512 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2342	110798786	modA	molybdate ABC transporter, molybdate-bin...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AMF	33.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90700 (show subtarget assignments)	8	soluble	No	Cj0196c	15791583	purF	amidophosphoribosyltransferase [Campylob...	445	Predicted Essential	Community Requests	1AO0	46.3%	Campylobacter jejuni

IDP00665 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1079	57285865	purF	amidophosphoribosyltransferase	494	Drug Target Function	Phase 2: March 2008	1AO0	51%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01497 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0820	15601575	groEL	chaperonin GroEL	530	Conserved Gene / Pathway	Phase 2: March 2008	1AON	74.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP02516 (show subtarget assignments)	1	purified	No	FTT1696	56708705	groEL	chaperonin GroEL [Francisella tularensis...	544	Conserved; Drug target functions	Phase 3: June 2008	1AON	73.3%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1695	56708704	groES	co-chaperonin GroES [Francisella tularen...	95	Conserved; Drug target functions	Phase 3: June 2008	1AON	56.8%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01312 (show subtarget assignments)	1	crystallized	No	VCA0819	15601574	groES	co-chaperonin GroES	96	Conserved Gene / Pathway	Phase 2: March 2008	1AON	65.6%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP00459 (show subtarget assignments)	1	cloned	No	YPO3371	16123520	cysI	sulfite reductase [NADPH] hemoprotein be...	576	Conserved Gene / Pathway	Phase 2: March 2008	1AOP	68.4%	Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP91825 (show subtarget assignments)	8	expressed	No	b3403	1789807	pck	phosphoenolpyruvate carboxykinase [Esche...	540	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1AQ2	100%	Escherichia coli

IDP01986 (show subtarget assignments)	1	soluble	No	YPO0138	16120481	pckA	phosphoenolpyruvate carboxykinase [Yersi...	539	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1AQ2	87.2%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP90532 (show subtarget assignments)	8	soluble	No	VC2391	15642388		dihydrodipicolinate reductase [Vibrio ch...	269	Predicted Essential	Community Requests	1ARZ	63.9%	Vibrio cholerae

IDP90934 (show subtarget assignments)	8	crystallized	No	YPO0480	16120810	dapB	dihydrodipicolinate reductase [Yersinia ...	273	Predicted Essential	Community Requests	1ARZ	79.5%	Yersinia pestis

IDP92107 (show subtarget assignments)	8	selected	No	TGME49_091640	237838437		aspartate carbamoyltransferase [Toxoplas...	423	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1AT1	30.5%	Toxoplasma gondii

IDP05339 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1622	57651958	glyS	glycyl-tRNA synthetase [Staphylococcus a...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	41.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05146 (show subtarget assignments)	1	cloned	No	BAS4784	49187774	-	glycyl-tRNA synthetase [Bacillus anthrac...	458	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	43.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP90621 (show subtarget assignments)	8	soluble	No	Cj0931c	15792260	argH	argininosuccinate lyase [Campylobacter j...	460	Predicted Essential	Community Requests	1AUW	44.8%	Campylobacter jejuni

IDP01649 (show subtarget assignments)	1	expressed	No	CBU_0796	29541390		HIT family protein [Coxiella burnetii RS...	113	Conserved; Drug target functions	Phase 3: June 2008	1AV5	49.6%	Coxiella burnetii	Unknown function	General

IDP01517 (show subtarget assignments)	1	expressed	No	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP04277 (show subtarget assignments)	1	cloned	No	BAS3960	49186958		PTS system, glucose-specific IIABC compo...	687	Proposed to be essential proteins	Phase 4: April 2009	1AX3	14.7%	Bacillus anthracis

IDP00703 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0250	57286711		PTS system, IIA component	263	Conserved Gene / Pathway	Phase 2: March 2008	1AX3	21.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01646 (show subtarget assignments)	1	soluble	No	GBAA5119	47530423	glgP	glycogen phosphorylase [Bacillus anthrac...	802	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AXR	46.5%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91441 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0468	27363935		response regulator [Vibrio vulnificus CM...	229	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1B00	45.9%	Vibrio vulnificus

IDP02820 (show subtarget assignments)	1	purified	No	lmo2196	16804235		hypothetical protein lmo2196 [Listeria m...	558	Known virulence-Intracellular Survival; PMID:11083832	Phase 3: June 2008	1B05	30.1%	Listeria monocytogenes	Cellular processes	DNA transformation

IDP05387 (show subtarget assignments)	1	purified	No	BA_2041	30256692		putative oligopeptide ABC transporter, o...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05711 (show subtarget assignments)	1	soluble	No	BAS1732	49184745	-	oligopeptide ABC transporter, solute bin...	519	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05600 (show subtarget assignments)	1	soluble	No	BA_3645	30258170		putative oligopeptide ABC transporter, o...	562	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05149 (show subtarget assignments)	1	purified	No	BA_0194	30253701		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	30.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05713 (show subtarget assignments)	1	cloned	No	BA_0189	30253696		oligopeptide ABC transporter, oligopepti...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP91952 (show subtarget assignments)	8	selected	No	SpneCM_010100008682	298255656		AmiA protein [Streptococcus pneumoniae s...	659	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B05	23.4%	Streptococcus pneumoniae

IDP05599 (show subtarget assignments)	1	purified	No	BA_3642	30258168		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP00850
(show subtarget assignments)

1

purified

No

SACOL2389

57285120

transcriptional regulatory protein DegU,...

217

Conserved Gene / Pathway

Phase 2: March 2008

1A04

31.3%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP02023
(show subtarget assignments)

1

soluble

No

STM3661

16766946

xylA

xylose isomerase [Salmonella typhimurium...

440

Conserved; Drug target functions

Phase 3: June 2008

1A0D

51.6%

Salmonella enterica

Energy metabolism

Sugars

IDP91466
(show subtarget assignments)

8

soluble

No

VV1_0078

27363563

site-specific recombinase XerC [Vibrio v...

234

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1A0P

20.1%

Vibrio vulnificus

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP00445
(show subtarget assignments)

1

purified

No

YPO3843

16123978

xerC

site-specific tyrosine recombinase XerC ...

303

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

35.6%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP05241
(show subtarget assignments)

1

cloned

No

lmo1955

16803994

-

hypothetical protein lmo1955 [Listeria m...

297

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

43.8%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP04653
(show subtarget assignments)

1

expressed

No

FTT1503

56708541

xerC

integrase/recombinase XerC [Francisella ...

292

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A0P

34.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00446
(show subtarget assignments)

1

purified

No

YPO0892

16121197

xerD

site-specific tyrosine recombinase XerD ...

299

Conserved Gene / Pathway

Phase 2: March 2008

1A0P

80.9%

Yersinia pestis

DNA metabolism

DNA replication, recombination, and repair

IDP05681
(show subtarget assignments)

1

cloned

No

lmo1277

16803317

codV

hypothetical protein lmo1277 [Listeria m...

300

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

35%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP00418
(show subtarget assignments)

1

crystallized

No

YPO0910

16121215

pepP

proline aminopeptidase P II

437

Drug Target Function

Phase 2: March 2008

1A16

81.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01514
(show subtarget assignments)

1

purified

No

VCA0518

15601278

fructose-specific PTS IIA/HPr components...

400

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

11.5%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00505
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1298

16121580

fruB

fructose-specific PTS IIA/HPr components...

377

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00885
(show subtarget assignments)

1

purified

No

STM2206

16765536

fruF

fructose-specific PTS IIA/HPr components...

376

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17.3%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00818
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2148

57286362

PTS system, mannitol-specific IIA compon...

144

Drug Target Function

Phase 2: March 2008

1A3A

34.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01118
(show subtarget assignments)

1

crystallized

No

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04388
(show subtarget assignments)

1

soluble

No

VC2751

15642744

adenosine deaminase [Vibrio cholerae O1 ...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A4L

32.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP92021
(show subtarget assignments)

8

selected

No

TGME49_005720

237837011

adenosine/AMP deaminase domain containin...

366

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1A4L

25.7%

Toxoplasma gondii

IDP90644
(show subtarget assignments)

8

in_crystallization_trials

No

STM1201

16764556

holB

DNA polymerase III subunit delta' [Salmo...

334

Predicted Essential

Community Requests

1A5T

79%

Salmonella enterica

IDP91261
(show subtarget assignments)

8

soluble

No

NT05BA0041

49176992

DNA polymerase III, delta prime subunit ...

327

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A5T

20.2%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP90607
(show subtarget assignments)

8

purified

No

VC2015

15642017

DNA polymerase III subunit delta' [Vibri...

324

Predicted Essential

Community Requests

1A5T

33%

Vibrio cholerae

IDP90924
(show subtarget assignments)

8

purified

No

YPO1606

16121874

holB

DNA polymerase III subunit delta' [Yersi...

340

Predicted Essential

Community Requests

1A5T

51.5%

Yersinia pestis

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP90548
(show subtarget assignments)

8

cloned

No

Cj0960c

15792289

rnpA

ribonuclease P protein component [Campyl...

108

Predicted Essential

Community Requests

1A6F

27.9%

Campylobacter jejuni

IDP01812
(show subtarget assignments)

1

cloned

No

FTT1764c

56708759

ferredoxin [Francisella tularensis subsp...

107

Conserved; Drug target functions

Phase 3: June 2008

1A6L

64.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP91274
(show subtarget assignments)

8

soluble

No

NT05BA4272

49181014

acetyl-CoA carboxylase, biotin carboxyl ...

164

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A6X

23.2%

Bacillus anthracis

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90751
(show subtarget assignments)

8

cloned

No

Cj1291c

15792614

accB

acetyl-CoA carboxylase biotin carboxyl c...

151

Predicted Essential

Community Requests

1A6X

27.2%

Campylobacter jejuni

IDP90589
(show subtarget assignments)

8

soluble

No

VC0296

15640324

acetyl-CoA carboxylase [Vibrio cholerae ...

196

Predicted Essential

Community Requests

1A6X

37.2%

Vibrio cholerae

IDP01749
(show subtarget assignments)

1

purified

No

Cj1224

15792548

putative iron-binding protein [Campyloba...

199

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1A7D

18.1%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01891
(show subtarget assignments)

1

purified

No

STM3464

16766752

prkB

putative phosphoribulokinase [Salmonella...

289

Conserved; Drug target functions

Phase 3: June 2008

1A7J

50.5%

Salmonella enterica

Energy metabolism

Sugars

IDP01471
(show subtarget assignments)

1

purified

No

VC2613

15642608

phosphoribulokinase

289

Conserved Gene / Pathway

Phase 2: March 2008

1A7J

51.6%

Vibrio cholerae

Energy metabolism

Sugars

IDP02096
(show subtarget assignments)

1

cloned

No

YPO0178

16120519

prk

phosphoribulokinase 1 [Yersinia pestis C...

289

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1A7J

49.5%

Yersinia pestis

Energy metabolism

Photosynthesis

IDP04687
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04009
(show subtarget assignments)

1

cloned

No

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP00421
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1331

16121613

potF

putrescine transporter subunit: periplas...

369

Virulence Associated Factor

Phase 2: March 2008

1A99

82.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02388
(show subtarget assignments)

1

soluble

No

YPO1407

16121687

hypothetical protein YPO1407 [Yersinia p...

618

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1A9U

25.6%

Yersinia pestis

Cell envelope

Other

IDP90949
(show subtarget assignments)

8

purified

No

ZZZ_0019

20986512

MAPK14

mitogen-activated protein kinase 14 isof...

360

Drug Target

Community Requests

1A9U

100%

Homo sapiens

IDP90274
(show subtarget assignments)

8

selected

No

TGME49_015260

211968509

carbamoyl phosphate synthetase II [Toxop...

1699

Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...

Community Requests

1A9X

27.1%

Toxoplasma gondii

IDP00574
(show subtarget assignments)

1

cloned

No

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00192
(show subtarget assignments)

1

cloned

No

YPO0947

16121251

-

putative virulence determinant

3110

Virulence

Phase 1: October 2007

1AF0

2.9%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00989
(show subtarget assignments)

1

purified

No

STM2183

16765513

cdd

cytidine deaminase

294

Conserved Gene / Pathway

Phase 2: March 2008

1AF2

87.4%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01459
(show subtarget assignments)

1

soluble

No

VC2420

161581987

flavodoxin

172

Conserved Gene / Pathway

Phase 2: March 2008

1AG9

45.3%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01446
(show subtarget assignments)

1

in_crystallization_trials

No

VC2099

15642099

flavodoxin FldA

175

Conserved Gene / Pathway

Phase 2: March 2008

1AG9

75.4%

Vibrio cholerae

Energy metabolism

Electron transport

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP90777
(show subtarget assignments)

8

soluble

No

YPO3849

16123984

hemC

porphobilinogen deaminase [Yersinia pest...

313

Predicted Essential

Community Requests

1AH5

80.5%

Yersinia pestis

IDP90701
(show subtarget assignments)

8

soluble

No

Cj0545

15791906

hemC

porphobilinogen deaminase [Campylobacter...

307

Predicted Essential

Community Requests

1AH5

47.9%

Campylobacter jejuni

IDP01663
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90821
(show subtarget assignments)

8

soluble

No

VC0120

15640152

hemC

porphobilinogen deaminase [Vibrio choler...

317

Predicted Essential

Community Requests

1AH5

73.5%

Vibrio cholerae

IDP02205
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0259

56707415

hemC

hydroxymethylbilane synthase (porphobili...

300

Conserved; Drug target functions

Phase 3: June 2008

1AH5

54.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01069
(show subtarget assignments)

1

soluble

No

STM3938

16767209

hemC

porphobilinogen deaminase

318

Conserved Gene / Pathway

Phase 2: March 2008

1AH5

87.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02257
(show subtarget assignments)

1

expressed

No

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02620
(show subtarget assignments)

1

cloned

No

lmo0205

16802251

plcB

phospholipase C [Listeria monocytogenes ...

289

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...

Phase 3: June 2008

1AH7

32.5%

Listeria monocytogenes

Cellular processes

Toxin production and resistance

IDP02148
(show subtarget assignments)

1

cloned

No

GBAA0133

47525389

infA

translation initiation factor IF-1 [Baci...

72

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AH9

72.2%

Bacillus anthracis

Protein synthesis

Translation factors

IDP90643
(show subtarget assignments)

8

soluble

No

VC0638

15640658

dihydropteroate synthase [Vibrio cholera...

278

Predicted Essential

Community Requests

1AJ0

55.8%

Vibrio cholerae

IDP90642
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0585

15791945

folP

dihydropteroate synthase [Campylobacter ...

380

Predicted Essential

Community Requests

1AJ0

25.8%

Campylobacter jejuni

IDP90287
(show subtarget assignments)

8

purified

No

TGME49_021210

211967615

18 kDa cyclophilin [Toxoplasma gondii ME...

179

Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...

Community Requests

1AK4

53.6%

Toxoplasma gondii

IDP01228
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4283

30258785

peptidyl-prolyl cis-trans isomerase, cyc...

145

Conserved Gene / Pathway

Phase 2: March 2008

1AK4

42.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02287
(show subtarget assignments)

1

purified

No

FTT1161

56708232

adk

adenylate kinase [Francisella tularensis...

218

Drug Target

Phase 3: June 2008

1AKE

56.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00480
(show subtarget assignments)

1

soluble

No

YPO3118

16123283

adk

adenylate kinase

214

Conserved Gene / Pathway

Phase 2: March 2008

1AKE

87.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP91820
(show subtarget assignments)

8

soluble

No

b0474

1786680

adk

adenylate kinase [Escherichia coli str. ...

214

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1AKE

100%

Escherichia coli

IDP04500
(show subtarget assignments)

1

crystallized

No

VC0986

15641001

adk

adenylate kinase [Vibrio cholerae O1 bio...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AKE

73.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00519
(show subtarget assignments)

1

cloned

No

YPO3446

16123594

argI

ornithine carbamoyltransferase subunit I...

335

Conserved Gene / Pathway

Phase 2: March 2008

1AKM

79.1%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00586
(show subtarget assignments)

1

purified

No

YPO3789

16123923

metR

lysR-family transcriptional regulatory p...

317

Virulence Associated Factor

Phase 2: March 2008

1AL3

23.7%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02111
(show subtarget assignments)

1

in_crystallization_trials

No

STM3694

16766979

lldD

L-lactate dehydrogenase [Salmonella typh...

396

Conserved; Drug target functions

Phase 3: June 2008

1AL7

32.6%

Salmonella enterica

Energy metabolism

Aerobic

IDP05504
(show subtarget assignments)

1

purified

No

CD0869

126698446

modA

putative molybdenum ABC transporter,subs...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

31.9%

Clostridium difficile

Transport and binding proteins: Anions

IDP05678
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1041

16803081

-

hypothetical protein lmo1041 [Listeria m...

256

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

30.9%

Listeria monocytogenes

Transport and binding proteins: Cations and iron carrying compounds

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP04512
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2342

110798786

modA

molybdate ABC transporter, molybdate-bin...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AMF

33.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90700
(show subtarget assignments)

8

soluble

No

Cj0196c

15791583

purF

amidophosphoribosyltransferase [Campylob...

445

Predicted Essential

Community Requests

1AO0

46.3%

Campylobacter jejuni

IDP00665
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1079

57285865

purF

amidophosphoribosyltransferase

494

Drug Target Function

Phase 2: March 2008

1AO0

51%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01497
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0820

15601575

groEL

chaperonin GroEL

530

Conserved Gene / Pathway

Phase 2: March 2008

1AON

74.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP02516
(show subtarget assignments)

1

purified

No

FTT1696

56708705

groEL

chaperonin GroEL [Francisella tularensis...

544

Conserved; Drug target functions

Phase 3: June 2008

1AON

73.3%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1695

56708704

groES

co-chaperonin GroES [Francisella tularen...

95

Conserved; Drug target functions

Phase 3: June 2008

1AON

56.8%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01312
(show subtarget assignments)

1

crystallized

No

VCA0819

15601574

groES

co-chaperonin GroES

96

Conserved Gene / Pathway

Phase 2: March 2008

1AON

65.6%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP00459
(show subtarget assignments)

1

cloned

No

YPO3371

16123520

cysI

sulfite reductase [NADPH] hemoprotein be...

576

Conserved Gene / Pathway

Phase 2: March 2008

1AOP

68.4%

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP91825
(show subtarget assignments)

8

expressed

No

b3403

1789807

pck

phosphoenolpyruvate carboxykinase [Esche...

540

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1AQ2

100%

Escherichia coli

IDP01986
(show subtarget assignments)

1

soluble

No

YPO0138

16120481

pckA

phosphoenolpyruvate carboxykinase [Yersi...

539

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1AQ2

87.2%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP90532
(show subtarget assignments)

8

soluble

No

VC2391

15642388

dihydrodipicolinate reductase [Vibrio ch...

269

Predicted Essential

Community Requests

1ARZ

63.9%

Vibrio cholerae

IDP90934
(show subtarget assignments)

8

crystallized

No

YPO0480

16120810

dapB

dihydrodipicolinate reductase [Yersinia ...

273

Predicted Essential

Community Requests

1ARZ

79.5%

Yersinia pestis

IDP92107
(show subtarget assignments)

8

selected

No

TGME49_091640

237838437

aspartate carbamoyltransferase [Toxoplas...

423

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1AT1

30.5%

Toxoplasma gondii

IDP05339
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1622

57651958

glyS

glycyl-tRNA synthetase [Staphylococcus a...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

41.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05146
(show subtarget assignments)

1

cloned

No

BAS4784

49187774

-

glycyl-tRNA synthetase [Bacillus anthrac...

458

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

43.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP90621
(show subtarget assignments)

8

soluble

No

Cj0931c

15792260

argH

argininosuccinate lyase [Campylobacter j...

460

Predicted Essential

Community Requests

1AUW

44.8%

Campylobacter jejuni

IDP01649
(show subtarget assignments)

1

expressed

No

CBU_0796

29541390

HIT family protein [Coxiella burnetii RS...

113

Conserved; Drug target functions

Phase 3: June 2008

1AV5

49.6%

Coxiella burnetii

Unknown function

General

IDP01517
(show subtarget assignments)

1

expressed

No

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP04277
(show subtarget assignments)

1

cloned

No

BAS3960

49186958

PTS system, glucose-specific IIABC compo...

687

Proposed to be essential proteins

Phase 4: April 2009

1AX3

14.7%

Bacillus anthracis

IDP00703
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0250

57286711

PTS system, IIA component

263

Conserved Gene / Pathway

Phase 2: March 2008

1AX3

21.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01646
(show subtarget assignments)

1

soluble

No

GBAA5119

47530423

glgP

glycogen phosphorylase [Bacillus anthrac...

802

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AXR

46.5%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91441
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0468

27363935

response regulator [Vibrio vulnificus CM...

229

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1B00

45.9%

Vibrio vulnificus

IDP02820
(show subtarget assignments)

1

purified

No

lmo2196

16804235

hypothetical protein lmo2196 [Listeria m...

558

Known virulence-Intracellular Survival; PMID:11083832

Phase 3: June 2008

1B05

30.1%

Listeria monocytogenes

Cellular processes

DNA transformation

IDP05387
(show subtarget assignments)

1

purified

No

BA_2041

30256692

putative oligopeptide ABC transporter, o...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05711
(show subtarget assignments)

1

soluble

No

BAS1732

49184745

-

oligopeptide ABC transporter, solute bin...

519

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05600
(show subtarget assignments)

1

soluble

No

BA_3645

30258170

putative oligopeptide ABC transporter, o...

562

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05149
(show subtarget assignments)

1

purified

No

BA_0194

30253701

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

30.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05713
(show subtarget assignments)

1

cloned

No

BA_0189

30253696

oligopeptide ABC transporter, oligopepti...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP91952
(show subtarget assignments)

8

selected

No

SpneCM_010100008682

298255656

AmiA protein [Streptococcus pneumoniae s...

659

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B05

23.4%

Streptococcus pneumoniae

IDP05599
(show subtarget assignments)

1

purified

No

BA_3642

30258168

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines