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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91244
(
show subtarget assignments
)
8
soluble
No
HP0663
0
365
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1UM0
100%
Helicobacter pylori
Amino acid biosynthesis: Aromatic amino acid family
IDP91660
(
show subtarget assignments
)
8
selected
No
LAMA5_HUMAN
0
3695
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
9.6%
Homo sapiens
IDP91668
(
show subtarget assignments
)
8
selected
No
Q914E0_9ENTO
0
2194
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJD
20.6%
Human echovirus
IDP91744
(
show subtarget assignments
)
8
selected
No
Q76ZW2_VACCW
0
190
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1OYI
39.5%
Vaccinia virus
IDP91053
(
show subtarget assignments
)
8
in_crystallization_trials
No
ENC0002
0
247
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
42.1%
Enterobacter cloacae
IDP91741
(
show subtarget assignments
)
8
selected
No
Q6V4L4_STRPY
0
397
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
22.4%
Streptococcus pyogenes
IDP91674
(
show subtarget assignments
)
8
selected
No
CGA1_HELPY
0
1147
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3IEC
6.9%
Helicobacter pylori
IDP91089
(
show subtarget assignments
)
8
soluble
No
NT06FT0892
0
323
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
31.9%
Francisella tularensis
Energy metabolism: Sugars
IDP91747
(
show subtarget assignments
)
8
selected
No
Q8WLQ7_HUMAN
0
79
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1D5M
94.9%
Homo sapiens
IDP91738
(
show subtarget assignments
)
8
selected
No
Q5YB85_STRSG
0
598
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
15.1%
Streptococcus sp.
IDP91749
(
show subtarget assignments
)
8
selected
No
Q9DUM3_HHV8
0
1036
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3H0G
9.3%
Human herpesvirus
IDP91739
(
show subtarget assignments
)
8
selected
No
Q6V4K9_STRPY
0
310
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2XNX
17.1%
Streptococcus pyogenes
IDP91669
(
show subtarget assignments
)
8
selected
No
AGSK1_HUMAN
0
129
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Homo sapiens
IDP91742
(
show subtarget assignments
)
8
selected
No
Q6V4L9_STRPY
0
391
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2TMA
18.4%
Streptococcus pyogenes
IDP91757
(
show subtarget assignments
)
8
selected
No
VF01_VACCW
0
226
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2VTY
73%
Vaccinia virus
IDP91754
(
show subtarget assignments
)
8
selected
No
TVB1_HUMAN
0
116
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3UTP
80.2%
Homo sapiens
IDP91732
(
show subtarget assignments
)
8
selected
No
O67990_VIBMI
0
628
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y3U
16.6%
Vibrio mimicus
IDP91240
(
show subtarget assignments
)
8
cloned
No
HP1280
0
335
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1KGZ
39.4%
Helicobacter pylori
Amino acid biosynthesis: Aromatic amino acid family
IDP91748
(
show subtarget assignments
)
8
selected
No
Q933J5_PSEAE
0
453
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1R4T
30.5%
Pseudomonas aeruginosa
IDP91746
(
show subtarget assignments
)
8
selected
No
Q8BDF8_9POXV
0
500
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Vaccinia virus
IDP91667
(
show subtarget assignments
)
8
selected
No
POLG_CXB3W
0
2185
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJD
20.7%
Coxsackievirus B3
IDP91672
(
show subtarget assignments
)
8
selected
No
ARP4_STRPY
0
386
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1I84
19.7%
Streptococcus pyogenes
IDP91683
(
show subtarget assignments
)
8
selected
No
MYC_HUMAN
0
439
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1NKP
18.9%
Homo sapiens
IDP91666
(
show subtarget assignments
)
8
selected
No
NS1_I68A0
0
237
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3F5T
77.2%
Influenza A
IDP91733
(
show subtarget assignments
)
8
selected
No
P88946_HHV8
0
449
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DLL
6.9%
Human herpesvirus
IDP91675
(
show subtarget assignments
)
8
selected
No
CREB3_HUMAN
0
395
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Homo sapiens
IDP91751
(
show subtarget assignments
)
8
selected
No
STRP_STREQ
0
440
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1BML
81.1%
Streptococcus dysgalactiae
IDP91753
(
show subtarget assignments
)
8
selected
No
TSST_STAAU
0
234
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJ0
82.5%
Staphylococcus aureus
IDP91752
(
show subtarget assignments
)
8
selected
No
TIP_SHV2C
0
256
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Herpesvirus saimiri
IDP91670
(
show subtarget assignments
)
8
selected
No
ANTR2_HUMAN
0
489
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SHU
37%
Homo sapiens
IDP91755
(
show subtarget assignments
)
8
selected
No
TXD11_HUMAN
0
958
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2B5E
7%
Homo sapiens
IDP91756
(
show subtarget assignments
)
8
selected
No
VF01_VACCP
0
206
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2VTY
81.1%
Vaccinia virus
IDP91745
(
show subtarget assignments
)
8
selected
No
Q846V4_STAAU
0
660
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A1D
45.6%
Staphylococcus aureus
IDP91743
(
show subtarget assignments
)
8
selected
No
Q76ZN6_VACCW
0
219
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2VGA
90.9%
Vaccinia virus
IDP91735
(
show subtarget assignments
)
8
selected
No
Q4W8J9_STAAU
0
663
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2A1D
29.9%
Staphylococcus aureus
IDP91737
(
show subtarget assignments
)
8
selected
No
Q5WMC9_ECOLX
0
550
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1F02
11.1%
Escherichia coli
IDP91736
(
show subtarget assignments
)
8
selected
No
Q51451_PSEAE
0
453
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1R4T
30.7%
Pseudomonas aeruginosa
IDP91678
(
show subtarget assignments
)
8
selected
No
H5_VACCW
0
203
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
Vaccinia virus
IDP91680
(
show subtarget assignments
)
8
cloned
No
INLB_LISMO
0
630
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1M9S
93.7%
Listeria monocytogenes
IDP91676
(
show subtarget assignments
)
8
selected
No
DNJA3_HUMAN
0
480
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3LZ8
19.6%
Homo sapiens
IDP91734
(
show subtarget assignments
)
8
selected
No
PTN11_HUMAN
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2SHP
88%
Homo sapiens
IDP91740
(
show subtarget assignments
)
8
selected
No
Q6V4L1_STRPY
0
398
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2XNX
14.6%
Streptococcus pyogenes
IDP91671
(
show subtarget assignments
)
8
selected
No
VK03_VACCC
0
88
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1LUZ
98.9%
Vaccinia virus
IDP91684
(
show subtarget assignments
)
8
selected
No
NCAP_CVHSA
0
422
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SSK
32.9%
SARS coronavirus
IDP91681
(
show subtarget assignments
)
8
selected
No
LAMC3_HUMAN
0
1587
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2Y38
8.9%
Homo sapiens
IDP91758
(
show subtarget assignments
)
8
selected
No
VWF_HUMAN
0
2813
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1SQ0
7.5%
Homo sapiens
IDP91673
(
show subtarget assignments
)
8
selected
No
CD44_HUMAN
0
742
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1POZ
21.4%
Homo sapiens
IDP91750
(
show subtarget assignments
)
8
selected
No
SPG2_STRSG
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2KN4
12.1%
Streptococcus sp.
IDP01183
(
show subtarget assignments
)
1
purified
No
BA_0266
60389755
10 kDa chaperonin (Protein Cpn10) (groES...
94
Conserved Gene / Pathway
Phase 2: March 2008
1WNR
66%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP90887
(
show subtarget assignments
)
8
cloned
No
YPO0104
16120451
menA
1,4-dihydroxy-2-naphthoate octaprenyltra...
305
Predicted Essential
Community Requests
Yersinia pestis
IDP00985
(
show subtarget assignments
)
1
soluble
No
STM2076
16765406
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosy...
245
Conserved Gene / Pathway
Phase 2: March 2008
2Y85
35.1%
Salmonella enterica
Amino acid biosynthesis
Histidine family
IDP01917
(
show subtarget assignments
)
1
soluble
No
GBAA1429
47526701
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosy...
239
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1VZW
36.5%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP90547
(
show subtarget assignments
)
8
crystallized
No
Cj1601
15792906
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosy...
243
Predicted Essential
Community Requests
2X30
33.7%
Campylobacter jejuni
IDP91401
(
show subtarget assignments
)
8
soluble
No
VV1_0994
27364429
16 kDa heat shock protein A [Vibrio vuln...
144
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91051
(
show subtarget assignments
)
8
in_crystallization_trials
No
PRM0001
81687074
rmtC
16S rRNA methylase [Proteus mirabilis]
281
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
29.2%
Proteus mirabilis
IDP91052
(
show subtarget assignments
)
8
in_crystallization_trials
No
PSA0001
116063829
rmtD
16S rRNA methylase [Pseudomonas aerugino...
247
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
42.5%
Pseudomonas aeruginosa
IDP00073
(
show subtarget assignments
)
1
crystallized
No
NT01ST3324
16421221
rimM
16S rRNA processing protein
182
Essential
Phase 1: October 2007
3H9N
63.2%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP91456
(
show subtarget assignments
)
8
purified
No
VV1_0246
27363727
16S rRNA uridine-516 pseudouridylate syn...
347
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3DH3
45%
Vibrio vulnificus
IDP91360
(
show subtarget assignments
)
8
cloned
No
VV1_2843
27366125
16S rRNA uridine-516 pseudouridylate syn...
233
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1KSK
55.4%
Vibrio vulnificus
IDP90287
(
show subtarget assignments
)
8
purified
No
TGME49_021210
211967615
18 kDa cyclophilin [Toxoplasma gondii ME...
179
Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...
Community Requests
1AK4
53.6%
Toxoplasma gondii
IDP02367
(
show subtarget assignments
)
1
soluble
No
GBAA0213
47525471
1-acyl-sn-glycerol-3-phosphate acyltrans...
201
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00914
(
show subtarget assignments
)
1
soluble
No
STM0220
16763610
dxr
1-deoxy-D-xylulose 5-phosphate reductois...
398
Conserved Gene / Pathway
Phase 2: March 2008
1K5H
88.7%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00499
(
show subtarget assignments
)
1
in_pdb
3IIE
No
YPO1048
16121348
dxr
1-deoxy-D-xylulose 5-phosphate reductois...
398
Conserved Gene / Pathway
Phase 2: March 2008
3IIE
100%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP90655
(
show subtarget assignments
)
8
expressed
No
Cj1346c
15792669
dxr
1-deoxy-D-xylulose 5-phosphate reductois...
356
Predicted Essential
Community Requests
1R0K
36.2%
Campylobacter jejuni
IDP04402
(
show subtarget assignments
)
1
cloned
No
VC2254
15642252
1-deoxy-D-xylulose 5-phosphate reductois...
402
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1K5H
60.9%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02217
(
show subtarget assignments
)
1
purified
No
FTT1018c
56708107
dxs
1-deoxy-D-xylulose-5-phosphate synthase ...
615
Conserved; Drug target functions
Phase 3: June 2008
2O1S
56.3%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
OtherPyridoxine,Thiamine
IDP90880
(
show subtarget assignments
)
8
purified
No
YPO3177
16123339
dxs
1-deoxy-D-xylulose-5-phosphate synthase ...
619
Predicted Essential
Community Requests
2O1S
82.7%
Yersinia pestis
IDP00089
(
show subtarget assignments
)
0
work_stopped
No
NT01ST0526
16418927
dxs
1-deoxyxylulose-5-phosphate synthase; fl...
620
Essential
Phase 1: October 2007
2O1S
96.3%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02618
(
show subtarget assignments
)
1
cloned
No
STM2205
16765535
fruK
1-phosphofructokinase [Salmonella typhim...
312
Conserved; Drug target functions
Phase 3: June 2008
3CQD
31.1%
Salmonella enterica
Energy metabolism
Glycolysis/gluconeogenesis
IDP01785
(
show subtarget assignments
)
1
expressed
No
CBU_0667
29541271
dapD
2,3,4,5-tetrahydropyridine-2,6-dicarboxy...
271
Conserved; Drug target functions
Phase 3: June 2008
1KGQ
62.7%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP00571
(
show subtarget assignments
)
1
in_pdb
3GOS
No
YPO1041
16121341
dapD
2,3,4,5-tetrahydropyridine-2-carboxylate...
274
Virulence Associated Factor
Phase 2: March 2008
3GOS
100%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP01143
(
show subtarget assignments
)
1
in_pdb
3R8Y
No
BA_4194
30258698
2,3,4,5-tetrahydropyridine-2-carboxylate...
240
Drug Target Function
Phase 2: March 2008
3R8Y
100%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
IDP05126
(
show subtarget assignments
)
1
expressed
No
BA_4346
30258846
cpdB
2',3'-cyclic-nucleotide 2'-phosphodieste...
774
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3JYF
20.7%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides: Other
IDP00926
(
show subtarget assignments
)
1
soluble
No
STM0597
16763974
entB
2,3-dihydro-2,3-dihydroxybenzoate synthe...
285
Conserved Gene / Pathway
Phase 2: March 2008
2FQ1
88.4%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00927
(
show subtarget assignments
)
1
soluble
No
STM0598
16763975
entA
2,3-dihydroxybenzoate-2,3-dehydrogenase ...
251
Conserved Gene / Pathway
Phase 2: March 2008
2FWM
89.2%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP04313
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA2368
47527663
entA
2,3-dihydroxybenzoate-2,3-dehydrogenase ...
258
virulence factor; putative drug target function;
Phase 4: April 2009
2FWM
45.7%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Menaquinone and ubiquinone
IDP04676
(
show subtarget assignments
)
1
in_crystallization_trials
No
GBAA2370
47527665
dhbE
2,3-dihydroxybenzoate-AMP ligase [Bacill...
538
putative drug target function;
Phase 4: April 2009
1MD9
71.6%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02408
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1418
16121698
23S rRNA m(2)G2445 methyltransferase [Ye...
706
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3V8V
74.8%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91436
(
show subtarget assignments
)
8
cloned
No
VV1_0484
27363948
rluD
23S rRNA pseudouridine synthase D [Vibri...
325
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1QYU
69.8%
Vibrio vulnificus
IDP00551
(
show subtarget assignments
)
1
soluble
No
YPO0589
16120918
fadH
2,4-dienoyl-CoA reductase
673
Virulence Associated Factor
Phase 2: March 2008
1PS9
72.5%
Yersinia pestis
Fatty acid and phospholipid metabolism
Degradation
IDP01438
(
show subtarget assignments
)
1
expressed
No
VC1993
15641995
2,4-dienoyl-CoA reductase
666
Drug Target Function
Phase 2: March 2008
1PS9
56.6%
Vibrio cholerae
Fatty acid and phospholipid metabolism
Degradation
IDP01051
(
show subtarget assignments
)
1
expressed
No
STM3219
16766518
fadH
2,4-dieonyl-CoA reductase
672
Drug Target Function
Phase 2: March 2008
1PS9
85.6%
Salmonella enterica
Fatty acid and phospholipid metabolism
Degradation
IDP91528
(
show subtarget assignments
)
8
in_crystallization_trials
No
lpg1841
52629179
com1
27 kDa outer membrane protein [Legionell...
261
virulence/pathogenesis /
Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...
Community Requests
3GYK
25.7%
Legionella pneumophila
IDP00580
(
show subtarget assignments
)
1
purified
No
YPO0059
16120412
kbl
2-amino-3-ketobutyrate coenzyme A ligase...
403
Conserved Gene / Pathway
Phase 2: March 2008
1FC4
82.9%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP02561
(
show subtarget assignments
)
1
purified
No
FTT0714c
56707833
kbl
2-amino-3-ketobutyrate coenzyme A ligase...
398
Conserved; Drug target functions
Phase 3: June 2008
1FC4
62.1%
Francisella tularensis
Energy metabolism
Amino acids and amines
IDP01999
(
show subtarget assignments
)
1
soluble
No
FTT0942c
56708039
folK
2-amino-4-hydroxy-6-hydroxymethyldihydro...
421
Conserved; Drug target functions
Phase 3: June 2008
3MCM
99.1%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP04085
(
show subtarget assignments
)
1
expressed
No
VC0525
15640547
2-amino-4-hydroxy-6-hydroxymethyldihydro...
195
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2BMB
30.8%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Folic acid
IDP00520
(
show subtarget assignments
)
1
in_pdb
3F6M
3FPI
No
YPO3360
16123510
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
162
Conserved Gene / Pathway
Phase 2: March 2008
3F6M
100%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP01038
(
show subtarget assignments
)
1
in_pdb
3GHZ
No
STM2929
16766235
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
159
Drug Target Function
Phase 2: March 2008
3GHZ
100%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP01381
(
show subtarget assignments
)
1
purified
No
VC0529
15640551
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
158
Drug Target Function
Phase 2: March 2008
1GX1
74.7%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00331
(
show subtarget assignments
)
1
in_pdb
3RE3
Yes
FTT1128
56708205
ispF
2C-methyl-D-erythritol 2,4-cyclodiphosph...
159
Drug Target Function
Phase 2: March 2008
3RE3
100%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP05659
(
show subtarget assignments
)
1
cloned
No
lmo0236
16802282
-
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
157
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1GX1
61.8%
Listeria monocytogenes
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
IDP01181
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0085
38372318
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
158
Drug Target Function
Phase 2: March 2008
3F6M
64.6%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP00339
(
show subtarget assignments
)
1
expressed
No
FTT0711
56707830
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
229
Drug Target Function
Phase 2: March 2008
1H3M
37.1%
Francisella tularensis
IDP02564
(
show subtarget assignments
)
1
purified
No
GBAA0084
47525340
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
226
Conserved; Drug target functions
Phase 3: June 2008
1W77
36.7%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP90579
(
show subtarget assignments
)
8
soluble
No
VC0528
15640550
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
232
We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...
Community Requests
1H3M
53.9%
Vibrio cholerae
IDP01337
(
show subtarget assignments
)
1
in_pdb
3E9A
No
VC2175
15642174
2-dehydro-3-deoxyphosphooctonate aldolas...
283
Conserved Gene / Pathway
Phase 2: March 2008
3E9A
100%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90656
(
show subtarget assignments
)
8
purified
No
Cj0384c
15791751
kdsA
2-dehydro-3-deoxyphosphooctonate aldolas...
271
Predicted Essential
Community Requests
1FWN
55.7%
Campylobacter jejuni
IDP02378
(
show subtarget assignments
)
1
cloned
No
CBU_1675
29542234
kdsA
2-dehydro-3-deoxyphosphooctonate aldolas...
280
Conserved; Drug target functions
Phase 3: June 2008
3T4C
62.5%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04504
(
show subtarget assignments
)
1
cloned
No
VC2307
15642305
2-dehydropantoate 2-reductase [Vibrio ch...
296
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KS9
43.2%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Pantothenate and coenzyme A
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