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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00252
(
show subtarget assignments
)
1
in_crystallization_trials
No
130516
St. Louis encephalitis virus Envelope pr...
407
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
2I69
70.5%
St. Louis
IDP92559
(
show subtarget assignments
)
8
selected
No
1MWR_A
24987837
Chain A, Structure Of Semet Penicillin B...
646
potential drug target /
Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...
Community Requests
1MWR
97.4%
Staphylococcus aureus
IDP92560
(
show subtarget assignments
)
8
selected
No
1PYY_A
37927671
Chain A, Double Mutant Pbp2x T338aM339F ...
702
potential drug target /
Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...
Community Requests
1PYY
100%
Streptococcus pneumoniae
IDP92563
(
show subtarget assignments
)
8
selected
No
3E90_B
221046696
Chain B, West Nile Vi Rus Ns2b-Ns3protea...
198
potential drug target /
We have identified a number of small molecule inhibitor to West Nile and/or deng...
Community Requests
3E90
100%
West Nile
IDP92561
(
show subtarget assignments
)
8
selected
No
3EQV_A
209870568
Chain A, Crystal Structure Of Penicillin...
542
potential drug target /
Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...
Community Requests
3EQV
99.8%
Neisseria gonorrhoeae
IDP92564
(
show subtarget assignments
)
8
selected
No
3L6P_A
290560467
Chain A, Crystal Structure Of Dengue Vir...
236
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
3L6P
100%
Dengue virus
IDP91092
(
show subtarget assignments
)
8
soluble
No
A1S_1236
193076931
D-arabinose 5-phosphate isomerase [Acine...
325
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
32.9%
Acinetobacter baumannii
IDP91095
(
show subtarget assignments
)
8
in_pdb
3POL
No
A1S_1557
193077192
3-deoxy-manno-octulosonate cytidylyltran...
253
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3POL
100%
Acinetobacter baumannii
IDP90942
(
show subtarget assignments
)
8
expressed
No
A55_2372
124113375
ispE
4-diphosphocytidyl-2C-methyl-D-erythrito...
194
We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...
Community Requests
1OJ4
59.8%
Vibrio cholerae
IDP91868
(
show subtarget assignments
)
8
in_pdb
4F0Y
4EVY
No
AAA21889
455437
aac(6')-Ig
aminoglycoside 6'-N-acetyltransferase [A...
145
drug resistance /
confers resistance to aminoglycoside antibiotics by acetylation
Community Requests
4EVY
100%
Acinetobacter haemolyticus
IDP91787
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAA24786
148325
vanC
D-alanine-D-alanine ligase-related prote...
343
drug resistance /
D-Ala:D-Ser ligase
Community Requests
1E4E
39%
Enterococcus gallinarum
IDP91791
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAA24789
148330
vanH
vancomycin resistance protein [Enterococ...
322
drug resistance /
Dehydrogenase that reduces pyruvate to D-lactate, which is required to produce a...
Community Requests
3KB6
35.7%
Enterococcus faecium
IDP91779
(
show subtarget assignments
)
8
in_pdb
4E8I
4E8J
No
AAA26652
153043
lincosamide resistance protein [Staphylo...
161
drug resistance /
Resistance to lincosamides
Community Requests
4E8I
100%
Staphylococcus haemolyticus
IDP91546
(
show subtarget assignments
)
8
in_pdb
4E8L
No
AAA26683
398085
vat
acetyltransferase [Staphylococcus aureus...
219
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4E8L
100%
Staphylococcus aureus
IDP91056
(
show subtarget assignments
)
8
expressed
No
AAA42941
323448
viral polyprotein [Dengue virus 2]
3391
potential drug target /
A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...
Community Requests
2J7U
15.1%
Dengue virus
IDP92565
(
show subtarget assignments
)
8
selected
No
AAA66406
807601
nonstructural protein 1, partial [Dengue...
886
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
2WZQ
38.7%
Dengue virus
IDP91786
(
show subtarget assignments
)
8
selected
No
AAA98349
153077
vgh
vgh [Staphylococcus aureus]
299
drug resistance /
Hydrolase inactivating the B components of virginiamycin-like antibiotics
Community Requests
2Z2N
99.3%
Staphylococcus aureus
IDP00276
(
show subtarget assignments
)
1
soluble
No
AAA99437_115-280
323469
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
56%
Dengue virus
N/A
IDP00278
(
show subtarget assignments
)
1
selected
No
AAA99437_1474-2092
323469
N/A
NS3 RNA Helicase
619
Polyprotein processing, RNA replication
Phase 3: June 2008
2VBC
78.9%
Dengue virus
Transcription
N/A
IDP00279
(
show subtarget assignments
)
1
selected
No
AAA99437_2243-2483
323469
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00277
(
show subtarget assignments
)
1
cloned
No
AAA99437_5-114
323469
N/A
Capsid protein (C)
110
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
57.3%
Dengue virus
Unclassified
N/A
IDP00265
(
show subtarget assignments
)
1
selected
No
AAA99437_775-1129
323469
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP91871
(
show subtarget assignments
)
8
selected
No
AAB05624
1209528
vanYB
D,D-carboxypeptidase [Enterococcus faeca...
268
drug resistance /
confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...
Community Requests
Enterococcus faecalis
IDP91773
(
show subtarget assignments
)
8
purified
No
AAB05628
1209532
vanXB
D,D-dipeptidase [Enterococcus faecalis]
202
drug resistance /
D,D-dipeptidase
Community Requests
1R44
74.8%
Enterococcus faecalis
IDP91808
(
show subtarget assignments
)
8
selected
No
AAB07788
924760
CTCF
CTCF [Homo sapiens]
727
innate immunity /
CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...
Community Requests
1X6H
10.2%
Homo sapiens
IDP91796
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAB49832
1854639
gentamicin resistance protein [Enterococ...
306
other biological interest /
Kinase
Community Requests
3TDV
100%
Enterococcus gallinarum
IDP91792
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAB58447
2145190
aph
spectinomycin phosphotransferase [Legion...
331
other biological interest /
Kinase
Community Requests
3I0O
100%
Legionella pneumophila
IDP91634
(
show subtarget assignments
)
8
selected
No
AAC16023
2429143
exoU
ExoU [Pseudomonas aeruginosa]
687
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
4AKX
95.8%
Pseudomonas aeruginosa
IDP91777
(
show subtarget assignments
)
8
purified
No
AAC33914
3513664
sul1
Sul1 dihydropteroate synthase [Escherich...
279
drug resistance /
Dihydropteroate synthase (sulfonamide resistance)
Community Requests
1EYE
35.1%
Escherichia coli
IDP91869
(
show subtarget assignments
)
8
in_pdb
4E8O
No
AAC41391
547387
aac(6')-Ih
aac(6')-Ih [Acinetobacter baumannii]
146
drug resistance /
confers resistance to aminoglycoside antibiotics by acetylation
Community Requests
4E8O
100%
Acinetobacter baumannii
IDP91185
(
show subtarget assignments
)
8
cloned
No
AAC46367
2352978
477
virulence/pathogenesis /
FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...
Community Requests
1NY5
31.9%
Vibrio cholerae
IDP91595
(
show subtarget assignments
)
8
selected
No
AAC64366
3661463
arr-2
ribosylating transferase ARR-2 [Pseudomo...
150
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2HW2
51.3%
Pseudomonas aeruginosa
IDP02588
(
show subtarget assignments
)
6
cloned
No
AAC67800
3328615
gseA
KDO Transferase [Chlamydia trachomatis D...
431
KdtA is responsible for the formation of the genus-specific lipopolysaccharide e...
Phase 3: June 2008
2XCI
26.5%
Chlamydia trachomatis
N/A
N/A
IDP01697
(
show subtarget assignments
)
6
cloned
No
AAC68008
3328839
lpxB
Lipid A Disaccharide Synthase [Chlamydia...
607
LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...
Phase 3: June 2008
Chlamydia trachomatis
N/A
N/A
IDP91545
(
show subtarget assignments
)
8
expressed
No
AAC78336
3892237
ereA2
erythromycin esterase [Providencia stuar...
408
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Providencia stuartii
IDP91596
(
show subtarget assignments
)
8
selected
No
AAD02118
4104708
vanXst
D-ala-D-ala dipeptidase [Streptomyces to...
208
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1R44
62%
Streptomyces toyocaensis
IDP90254
(
show subtarget assignments
)
8
selected
No
AAK67494
21263110
ie1
IE1 protein [Human herpesvirus 6]
1078
(From requester) The IE1 protein of HHV-6, one of the first viral proteins synth...
Community Requests
Human herpesvirus
IDP92062
(
show subtarget assignments
)
8
selected
No
AAK85305
22073900
putative glutathione/thioredoxin peroxid...
251
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2P5Q
24.7%
Toxoplasma gondii
IDP91799
(
show subtarget assignments
)
8
selected
No
AAL27442
16612079
vanE
VanE [Enterococcus faecalis]
352
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1E4E
41.5%
Enterococcus faecalis
IDP91775
(
show subtarget assignments
)
8
in_crystallization_trials
No
AAL27443
16612080
vanXYE
VanXYE [Enterococcus faecalis]
193
drug resistance /
D,D-dipeptidase/D,D-carboxypeptidase
Community Requests
Enterococcus faecalis
IDP90204
(
show subtarget assignments
)
8
cloned
No
AAM13452.1
20152991
CPXV006 CDS
CPXV006 protein
619
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90169
(
show subtarget assignments
)
8
expressed
No
AAM13454.1
20152993
CPXV008 CDS
CPXV008 protein
672
Potential drug target. Shikimate pathway enzyme
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90170
(
show subtarget assignments
)
8
selected
No
AAM13458.1
20152997
CPXV011 CDS
CPXV011 protein
658
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90171
(
show subtarget assignments
)
8
cloned
No
AAM13460.1
20152999
CPXV013 CDS
CPXV013 protein
523
kelch-like protein
Community Requests
3HVE
10.1%
Cowpox virus
conserved hypothetical proteins
0
IDP90172
(
show subtarget assignments
)
8
cloned
No
AAM13463.1
20153002
CPXV016 CDS
CPXV016 protein
764
ankyrin repeat protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90173
(
show subtarget assignments
)
8
cloned
No
AAM13464.1
20153003
CPXV017 CDS
CPXV017 protein
435
ankyrin repeat protein
Community Requests
2BKG
9.9%
Cowpox virus
conserved hypothetical proteins
0
IDP90205
(
show subtarget assignments
)
8
expressed
No
AAM13465.1
20153004
CPXV018 CDS
CPXV018 protein, VO18
171
similar to MPV-Z-N3R
Community Requests
Cowpox virus
host defense modulator
0
IDP90174
(
show subtarget assignments
)
8
cloned
No
AAM13466.1
20153005
CPXV019 CDS
CPXV019 protein
796
ankyrin repeat protein
Community Requests
3HG0
3.8%
Cowpox virus
conserved hypothetical proteins
0
IDP90175
(
show subtarget assignments
)
8
expressed
No
AAM13468.1
20153007
VGF
CPXV021 protein or CPXV VGF protein
139
similar to viral growth factor C11R vaccinia virus
Community Requests
1K36
15.8%
Cowpox virus
host range protein
0
IDP90176
(
show subtarget assignments
)
8
expressed
No
AAM13470.1
20153009
CPXV023 CDS
CPXV023 protein
242
zinc-finger-like protein
Community Requests
2ECW
8.3%
Cowpox virus
host defense modulator
0
IDP90177
(
show subtarget assignments
)
8
expressed
No
AAM13471.1
20153010
CPXV024 CDS
CPXV024 protein
126
Orthopoxvirus interleukin 18 binding protein; plays a key role in the activation...
Community Requests
3F62
80.2%
Cowpox virus
host defense modulator
0
IDP90178
(
show subtarget assignments
)
8
purified
No
AAM13472.1
20153011
VHR1
VHR1 or CPXV025 protein
668
ankyrin-like protein, CP77
Community Requests
1N11
10%
Cowpox virus
host range protein
0
IDP90179
(
show subtarget assignments
)
8
cloned
No
AAM13473.1
20153012
CPXV025 CDS
CPXV026 protein
63
ankyrin-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90180
(
show subtarget assignments
)
8
cloned
No
AAM13474.1
20153013
CPXV027 CDS
CPXV027 protein
632
ankyrin-like protein
Community Requests
3NOC
5.4%
Cowpox virus
conserved hypothetical proteins
0
IDP90181
(
show subtarget assignments
)
8
cloned
No
AAM13478.1
20153017
CPXV031 CDS
CPXV031 protein
69
kelch-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90182
(
show subtarget assignments
)
8
soluble
No
AAM13479.1
20153018
CPXV032
CPXV032 protein
125
kelch-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90183
(
show subtarget assignments
)
8
cloned
No
AAM13482.1
20153021
CPXV035 CDS
CPXV035 protein
512
kelch-like protein
Community Requests
2XN4
12.7%
Cowpox virus
conserved hypothetical proteins
0
IDP90184
(
show subtarget assignments
)
8
expressed
No
AAM13486.1
20153025
CPXV039 CDS
CPXV039 protein
473
ankyrin repeat protein
Community Requests
1N11
14.4%
Cowpox virus
conserved hypothetical proteins
0
IDP90185
(
show subtarget assignments
)
0
work_stopped
No
AAM13488.1
20153027
CPXV041 CDS
CPXV041 protein
284
K1L like Host range protein
Community Requests
3KEA
95.1%
Cowpox virus
host defense modulator
0
IDP90186
(
show subtarget assignments
)
8
cloned
No
AAM13489.1
20153028
SPI3
SPI3 or CPXV042 protein
373
serine protease inhibitor 3
Community Requests
3LW2
28.7%
Cowpox virus
host defense modulator
0
IDP90187
(
show subtarget assignments
)
8
cloned
No
AAM13490.1
20153029
CPXV043 CDS
CPXV043 protein
88
IFN resistance, K3L like
Community Requests
1LUZ
90.9%
Cowpox virus
host defense modulator
0
IDP90188
(
show subtarget assignments
)
8
cloned
No
AAM13496.1
20153035
CPXV050 CDS
CPXV050 protein
480
kelch-like protein
Community Requests
3II7
12.3%
Cowpox virus
conserved hypothetical proteins
0
IDP90189
(
show subtarget assignments
)
8
cloned
No
AAM13616.1
20153155
CPXV175 CDS
CPXV175 protein
277
CD47-like putative membrane proteinÂ
Community Requests
2JJS
13%
Cowpox virus
host defense modulator
0
IDP90190
(
show subtarget assignments
)
8
cloned
No
AAM13631.1
20153170
CrmC
CrmC or CPXV191 protein
186
soluble vTNF receptor CrmC
Community Requests
3ALQ
30.6%
Cowpox virus
host defense modulator
0
IDP90191
(
show subtarget assignments
)
8
expressed
No
AAM13632.1
20153171
CPXV193 CDS
CPXV193 protein
563
kelch-like protein
Community Requests
3II7
13%
Cowpox virus
conserved hypothetical proteins
0
IDP90192
(
show subtarget assignments
)
8
cloned
No
AAM13635.1
20153174
CPXV196 CDS
CPXV196 protein
299
serine-threonine kinase
Community Requests
2KTY
40.7%
Cowpox virus
Unknown function
0
IDP90193
(
show subtarget assignments
)
8
cloned
No
AAM13637.1
20153176
CPXV198 CDS
CPXV198 protein
558
ankyrin-like protein
Community Requests
1N11
11.1%
Cowpox virus
conserved hypothetical proteins
0
IDP90194
(
show subtarget assignments
)
8
expressed
No
AAM13639.1
20153178
CPXV200 CDS
CPXV200 protein
179
ankyrin-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90195
(
show subtarget assignments
)
8
soluble
No
AAM13642.1
20153181
CPXV203 CDS
CPXV203 protein
225
ER-localized, MHC-I inhibitor
Community Requests
Cowpox virus
host defense modulator
0
IDP90196
(
show subtarget assignments
)
8
cloned
No
AAM13643.1
20153182
CPXV204 CDS
CPXV204 protein
501
kelch-like protein
Community Requests
2VPJ
14%
Cowpox virus
conserved hypothetical proteins
0
IDP90197
(
show subtarget assignments
)
8
soluble
No
AAM13645.1
20153184
CPXV206 CDS
CPXV206 protein
285
serine-threonine kinase
Community Requests
2KTY
32.1%
Cowpox virus
Unknown function
0
IDP90198
(
show subtarget assignments
)
8
expressed
No
AAM13648.1
20153187
CPXV209
CPXV209 protein
326
soluble secreted IL-1 binding protein
Community Requests
3O4O
28.5%
Cowpox virus
host defense modulator
0
IDP90199
(
show subtarget assignments
)
8
cloned
No
AAM13650.1
20153189
CPXV211 CDS
CPXV211 protein
574
ankyrin-like protein
Community Requests
3F6Q
5.6%
Cowpox virus
conserved hypothetical proteins
0
IDP90200
(
show subtarget assignments
)
8
purified
No
AAM13652.1
20153191
CPXV213 CDS
CPXV213 protein
800
ankyrin-like protein
Community Requests
Cowpox virus
conserved hypothetical proteins
0
IDP90201
(
show subtarget assignments
)
8
cloned
No
AAM13653.1
20153192
CPXV215 CDS
CPXV215 Protein
557
kelch-like protein
Community Requests
2VPJ
12.2%
Cowpox virus
conserved hypothetical proteins
0
IDP90202
(
show subtarget assignments
)
8
cloned
No
AAM13655.1
20153194
CPXV217 CDS
CPXV217 protein
372
serine-protease inhibitor (SPI-1)
Community Requests
1F0C
40.9%
Cowpox virus
host defense modulator
0
IDP90203
(
show subtarget assignments
)
8
selected
No
AAM13658.1
20153197
CPXV220 CDS
CPXV220 protein
579
ankyrin-like protein
Community Requests
2FO1
10.4%
Cowpox virus
conserved hypothetical proteins
0
IDP91783
(
show subtarget assignments
)
8
in_pdb
4EBK
4EBJ
No
AAM76670
30171089
ant4'-IIb
aminoglycoside nucleotidyltransferase [P...
251
drug resistance /
Aminoglycoside nucleotidyltransferase (ant4'-IIb) gene (aminoglycoside resistanc...
Community Requests
4EBJ
98.8%
Pseudomonas aeruginosa
IDP92566
(
show subtarget assignments
)
8
selected
No
AAO83387
29725867
polyprotein, partial [Dengue virus 4]
263
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
2VBC
67.7%
Dengue virus
IDP91774
(
show subtarget assignments
)
8
in_pdb
4F78
No
AAQ16272
33355852
vanXYG
D,D-dipeptidase/D,D-carboxypeptidase [En...
254
drug resistance /
D,D-dipeptidase/D,D-carboxypeptidase
Community Requests
Enterococcus faecalis
IDP91879
(
show subtarget assignments
)
8
selected
No
AAQ16273
33355853
vanG
D-Ala:D-Ser ligase [Enterococcus faecali...
349
drug resistance /
The proteins play important roles in vancomycin resistance of Entercocci.
Community Requests
3SE7
46.4%
Enterococcus faecalis
IDP91801
(
show subtarget assignments
)
8
purified
No
AAQ16565
33356632
DAHP synthetase [Toxoplasma gondii]
615
potential drug target /
The presence of the shikimate pathway in a large number of pathogenic organisms,...
Community Requests
2B7O
28.6%
Toxoplasma gondii
IDP91772
(
show subtarget assignments
)
8
expressed
No
AAR87481
40548828
sul3
dihydropteroate synthase [Escherichia co...
242
drug resistance /
Dihydropteroate synthase (sulfonamide resistance)
Community Requests
1TWS
36.4%
Escherichia coli
IDP92064
(
show subtarget assignments
)
8
selected
No
AAT47115
48857019
putative thioredoxin peroxidase TPX1/2 [...
333
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2P5Q
18.6%
Toxoplasma gondii
IDP92063
(
show subtarget assignments
)
8
selected
No
AAT47116
48857021
putative thioredoxin peroxidase TPX1/1 [...
252
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2P5Q
24.6%
Toxoplasma gondii
IDP91781
(
show subtarget assignments
)
8
purified
No
AAV80411
56155277
tetO
TetO [Enterococcus faecalis]
639
drug resistance /
Tetracycline resistance
Community Requests
1DAR
27.9%
Enterococcus faecalis
IDP02589
(
show subtarget assignments
)
0
work_stopped
No
AAW36394
57284300
gapA1
glyceraldehyde 3-phosphate dehydrogenase...
336
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), gapC, catalyzes the oxidative ...
Phase 3: June 2008
3K73
100%
Staphylococcus aureus
N/A
N/A
IDP91189
(
show subtarget assignments
)
1
in_pdb
4DE4
4DFB
4DFU
Yes
AAW59417
57918602
aph(2'')-Id
APH(2'')-Id [Enterococcus faecium]
301
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3LZH
100%
Enterococcus faecium
IDP91527
(
show subtarget assignments
)
8
cloned
No
AAX13509
89214483
etpA
EtpA [Escherichia coli ETEC H10407]
1767
virulence/pathogenesis /
The EtpA ETEC two-partner secretion (TPS) exoprotein [PMID: 16552055] is a highl...
Community Requests
3AK5
11.2%
Escherichia coli
IDP05773
(
show subtarget assignments
)
1
in_pdb
3OQ3
No
AAX23681
60547415
soluble interferon-alpha/beta receptor [...
358
essential/virulence/pathogenesis /
An ortholog of IDP90145 (EVM166), a monkeypox target. The description of the mou...
Phase 5: 2010
3OQ3
91.6%
Ectromelia virus
IDP00266
(
show subtarget assignments
)
1
cloned
No
AAX48017_114-279
61652905
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
57.2%
Dengue virus
N/A
IDP00282
(
show subtarget assignments
)
1
cloned
No
AAX48017_2243-2483
61652905
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00268
(
show subtarget assignments
)
1
cloned
No
AAX48017_2488-3387
61652905
N/A
NS5 methyl transferase and RNA polymeras...
900
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
54.7%
Dengue virus
Transcription
N/A
IDP00267
(
show subtarget assignments
)
1
cloned
No
AAX48017_4-113
61652905
N/A
Capsid protein (C)
111
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.4%
Dengue virus
Unclassified
N/A
IDP00280
(
show subtarget assignments
)
1
purified
No
AAX48017_51-545
604449
N/A
Envelope (E)
495
Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...
Phase 3: June 2008
3UAJ
79.2%
Dengue virus
N/A
IDP00281
(
show subtarget assignments
)
1
cloned
No
AAX48017_776-1130
61652905
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP91798
(
show subtarget assignments
)
8
purified
No
AAX82592
62422020
aph(6)-Ia
aminoglycoside-6-phosphotransferase Ia [...
307
other biological interest /
Kinase
Community Requests
Streptomyces griseus
IDP92247
(
show subtarget assignments
)
8
selected
No
ABA71730
77380198
vanWG
VanWG [Enterococcus faecalis]
281
drug resistance /
Community-requested targets (Patrice Courvalin, Pasteur Institute). Gene is foun...
Community Requests
Enterococcus faecalis
IDP92086
(
show subtarget assignments
)
8
selected
No
ABB03945
77819088
SOD1
iron-containing superoxide dismutase [To...
201
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2A03
59.7%
Toxoplasma gondii
IDP90081
(
show subtarget assignments
)
8
cloned
No
ABD79034.1
89892477
M2
matrix protein 2 [Influenza A virus (A/U...
96
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2L0J
42.7%
Influenza A
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