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Targets
Filter Targets:
Selection Phase:
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Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 10 of 60, showing 100 records out of 5973 total, starting on record 901
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91465
(
show subtarget assignments
)
8
expressed
No
VPA1380
28901235
putative OspB protein [Vibrio parahaemol...
295
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP04647
(
show subtarget assignments
)
1
purified
No
FTT1127
56604696
Rhodanese-like family protein [Francisel...
252
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YT8
18.3%
Francisella tularensis
IDP91375
(
show subtarget assignments
)
8
purified
No
VV1_2191
27365520
hypothetical protein VV1_2191 [Vibrio vu...
107
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91376
(
show subtarget assignments
)
8
purified
No
VV1_1694
27365055
hypothetical protein VV1_1694 [Vibrio vu...
151
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1IB8
29.8%
Vibrio vulnificus
IDP91374
(
show subtarget assignments
)
8
cloned
No
VV1_1919
27365265
outermembrane lipoprotein [Vibrio vulnif...
110
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05670
(
show subtarget assignments
)
1
cloned
No
lmo0617
16802659
-
hypothetical protein lmo0617 [Listeria m...
164
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91377
(
show subtarget assignments
)
8
cloned
No
VV1_1569
27364938
acpS
4'-phosphopantetheinyl transferase [Vibr...
126
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3OTA
73%
Vibrio vulnificus
IDP91403
(
show subtarget assignments
)
8
expressed
No
VV1_0950
27364390
integral membrane protein [Vibrio vulnif...
86
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91624
(
show subtarget assignments
)
8
expressed
No
BAB35497
13361540
ECs2074
hypothetical protein [Escherichia coli O...
222
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP91385
(
show subtarget assignments
)
8
soluble
No
VV1_1465
27364849
pyrB
aspartate carbamoyltransferase catalytic...
309
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2BE7
76.4%
Vibrio vulnificus
IDP05242
(
show subtarget assignments
)
1
cloned
No
lmo2079
16804118
-
hypothetical protein lmo2079 [Listeria m...
380
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04060
(
show subtarget assignments
)
8
selected
No
CAC05813
12329082
mxiI
MxiI, component of the Mxi-Spa secretion...
97
Shigella effector protein
Community Requests
Shigella flexneri
IDP04528
(
show subtarget assignments
)
1
expressed
No
STM2257_1_289
16765585
napH
quinol dehydrogenase membrane component ...
289
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP91379
(
show subtarget assignments
)
8
purified
No
VV1_1473
27364857
Zn-dependent protease with chaperone fun...
331
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3C37
17.2%
Vibrio vulnificus
IDP91384
(
show subtarget assignments
)
8
in_pdb
3UPD
Yes
VV1_1466
27364850
ornithine carbamoyltransferase [Vibrio v...
334
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3UPD
100%
Vibrio vulnificus
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP91378
(
show subtarget assignments
)
8
cloned
No
VV1_1552
27364921
2-octaprenyl-6-methoxyphenyl hydroxylase...
391
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2X3N
21.2%
Vibrio vulnificus
IDP04523
(
show subtarget assignments
)
1
cloned
No
STM0884_1_447
16764245
ulaA
ascorbate-specific PTS system enzyme IIC...
447
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04581
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0108
49183142
elongation factor Tu [Bacillus anthracis...
395
Proposed to be essential proteins
Phase 4: April 2009
3U2Q
75.4%
Bacillus anthracis
IDP04524
(
show subtarget assignments
)
1
in_pdb
3Q58
Yes
STM1129_1_226
16764486
N-acetylmannosamine-6-phosphate 2-epimer...
226
Salmonella essential protein
Phase 4: April 2009
3Q58
100%
Salmonella enterica
IDP04525
(
show subtarget assignments
)
1
cloned
No
STM1556_1_483
16764900
putative Na+/H+ antiporter [Salmonella t...
483
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04526
(
show subtarget assignments
)
1
expressed
No
STM1637_1_516
16764981
putative inner membrane protein [Salmone...
516
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP91382
(
show subtarget assignments
)
8
purified
No
VV1_1470
27364854
histone acetyltransferase HPA2 [Vibrio v...
164
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX0
18.9%
Vibrio vulnificus
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP04580
(
show subtarget assignments
)
1
cloned
No
BAS0103
49183137
DNA-directed RNA polymerase subunit beta...
1203
Proposed to be essential proteins
Phase 4: April 2009
2GHO
53.6%
Bacillus anthracis
IDP05256
(
show subtarget assignments
)
1
cloned
No
BA_1805
30256080
hypothetical protein BA_1805 [Bacillus a...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04534
(
show subtarget assignments
)
8
selected
No
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP04636
(
show subtarget assignments
)
1
soluble
No
FTT0238
56707395
aroE1
shikimate 5-dehydrogenase [Francisella t...
257
drug target; conserved gene;
Phase 4: April 2009
3O8Q
36.8%
Francisella tularensis
IDP91584
(
show subtarget assignments
)
8
expressed
No
CBU_0425
29541034
hypothetical protein
455
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP04539
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05775
12329044
ospD1
OspD1, secreted by the Mxi-Spa secretion...
225
Shigella effector protein
Community Requests
Shigella flexneri
IDP04055
(
show subtarget assignments
)
1
cloned
No
STM0301_1_836
16763684
safC
putative fimbrial usher [Salmonella typh...
836
Salmonella essential protein
Phase 4: April 2009
3RFZ
37%
Salmonella enterica
IDP91386
(
show subtarget assignments
)
8
cloned
No
VV1_1450
27364835
cell shape-determining protein [Vibrio v...
296
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2J5U
19.3%
Vibrio vulnificus
IDP91387
(
show subtarget assignments
)
8
in_pdb
3VCZ
No
VV1_1463
27364847
putative translation initiation inhibito...
129
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3VCZ
100%
Vibrio vulnificus
IDP04533
(
show subtarget assignments
)
1
cloned
No
STM4154_1_1407
16767408
rpoC
DNA-directed RNA polymerase subunit beta...
1407
Salmonella essential protein
Phase 4: April 2009
3IYD
98.6%
Salmonella enterica
IDP04530
(
show subtarget assignments
)
1
soluble
No
STM2519_1_490
16765839
engA
GTP-binding protein EngA [Salmonella typ...
490
Salmonella essential protein
Phase 4: April 2009
2HJG
36.1%
Salmonella enterica
IDP91389
(
show subtarget assignments
)
8
cloned
No
VV1_1437
27364822
Type II secretory pathway, component Exe...
282
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04637
(
show subtarget assignments
)
1
cloned
No
FTT0371c
56707522
folC
FolC bifunctional protein [Francisella t...
393
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1W78
29.8%
Francisella tularensis
IDP04045
(
show subtarget assignments
)
1
soluble
No
FTT1747
56708745
outer membrane protein [Francisella tula...
191
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Francisella tularensis
IDP04532
(
show subtarget assignments
)
1
cloned
No
STM3301_1_390
16766597
obgE
GTPase ObgE [Salmonella typhimurium LT2]...
390
Salmonella essential protein
Phase 4: April 2009
1LNZ
42.1%
Salmonella enterica
IDP91582
(
show subtarget assignments
)
8
cloned
No
CBU_0295
29540908
hypothetical protein
489
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91391
(
show subtarget assignments
)
8
cloned
No
VV1_1292
27364692
mutL
DNA mismatch repair protein [Vibrio vuln...
664
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B62
36.4%
Vibrio vulnificus
IDP04640
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0559c
56707689
cmk
cytidylate kinase [Francisella tularensi...
221
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1CKE
47.1%
Francisella tularensis
IDP91393
(
show subtarget assignments
)
8
cloned
No
VV1_1096
27364519
chromosome segregation ATPase [Vibrio vu...
265
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04535
(
show subtarget assignments
)
8
selected
No
CAC05816
12329085
mxiN
MxiN, putative component of the Mxi-Spa ...
231
Shigella effector protein
Community Requests
Shigella flexneri
IDP04538
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05770
12329039
ospB
OspB, protein secreted by the Mxi-Spa se...
288
Shigella effector protein
Community Requests
Shigella flexneri
IDP91392
(
show subtarget assignments
)
8
expressed
No
VV1_1289
27364689
hypothetical protein VV1_1289 [Vibrio vu...
373
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04120
(
show subtarget assignments
)
1
soluble
No
BAS1475
49184492
xanthine phosphoribosyltransferase [Baci...
197
Proposed to be essential proteins
Phase 4: April 2009
1Y0B
65%
Bacillus anthracis
IDP91464
(
show subtarget assignments
)
8
soluble
No
VV1_0086
27363570
P2-like prophage tail protein X [Vibrio ...
68
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91401
(
show subtarget assignments
)
8
soluble
No
VV1_0994
27364429
16 kDa heat shock protein A [Vibrio vuln...
144
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04537
(
show subtarget assignments
)
8
selected
No
CAC05780
12329049
virF
VirF, member of the AraC family of trans...
262
Shigella effector protein
Community Requests
3GBG
26.3%
Shigella flexneri
IDP04057
(
show subtarget assignments
)
1
purified
No
BAS0125
49183159
50S ribosomal protein L6 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1C04
74.9%
Bacillus anthracis
IDP91394
(
show subtarget assignments
)
8
purified
No
VV1_1133
27364552
hypothetical protein VV1_1133 [Vibrio vu...
201
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04536
(
show subtarget assignments
)
8
selected
No
CAC05826
12329095
spa32
Spa32, secreted by and component of the ...
292
Shigella effector protein
Community Requests
Shigella flexneri
IDP91396
(
show subtarget assignments
)
8
crystallized
No
VV1_1047
27364479
fmt
methionyl-tRNA formyltransferase [Vibrio...
315
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3Q0I
83.2%
Vibrio vulnificus
IDP04642
(
show subtarget assignments
)
1
expressed
No
FTT0716
56707835
upp
uracil phosphoribosyltransferase [Franci...
214
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2EHJ
69.2%
Francisella tularensis
IDP91397
(
show subtarget assignments
)
8
cloned
No
VV1_1074
27364497
transposase [Vibrio vulnificus CMCP6]
177
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP90258
(
show subtarget assignments
)
8
in_pdb
3KY7
No
SAR1216
49483403
trmD
putative tRNA (guanine-7-)-methyltransfe...
245
Potential drug target
Community Requests
3KY7
100%
Staphylococcus aureus
IDP91480
(
show subtarget assignments
)
8
expressed
No
VPA1327
28901182
putative exoenzyme T [Vibrio parahaemoly...
236
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP90256
(
show subtarget assignments
)
8
crystallized
No
SAR0409
49482642
guaA
bifunctional GMP synthase/glutamine amid...
513
(From requestor) Identified potential S. aureus drug target. Would like to devel...
Community Requests
1GPM
51.2%
Staphylococcus aureus
IDP91404
(
show subtarget assignments
)
8
soluble
No
VV1_0879
27364327
ribosome-associated heat shock protein i...
128
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1DM9
64.8%
Vibrio vulnificus
IDP05278
(
show subtarget assignments
)
1
cloned
No
BA_5456
30259924
hypothetical protein BA_5456 [Bacillus a...
49
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04654
(
show subtarget assignments
)
1
purified
No
FTT1526c
56708560
idh
isocitrate dehydrogenase [Francisella tu...
747
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1ITW
62.7%
Francisella tularensis
IDP04589
(
show subtarget assignments
)
1
expressed
No
BAS0135
49183169
30S ribosomal protein S13 [Bacillus anth...
121
Proposed to be essential proteins
Phase 4: April 2009
1FJG
63.9%
Bacillus anthracis
IDP04075
(
show subtarget assignments
)
8
selected
No
CAC05807
12329076
icsB
IcsB, function unknown [Shigella flexner...
494
Shigella effector protein
Community Requests
Shigella flexneri
IDP91405
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0801
27364250
dehydrogenase [Vibrio vulnificus CMCP6]
313
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3GDO
15%
Vibrio vulnificus
IDP04574
(
show subtarget assignments
)
1
soluble
No
BAS0015
49183051
seryl-tRNA synthetase [Bacillus anthraci...
424
Proposed to be essential proteins
Phase 4: April 2009
2DQ3
57.8%
Bacillus anthracis
IDP05689
(
show subtarget assignments
)
1
cloned
No
lmo1654
16803694
-
putative cellsurface protein [Listeria m...
164
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91412
(
show subtarget assignments
)
8
soluble
No
VV1_0715
27364170
transcriptional regulator [Vibrio vulnif...
183
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05653
(
show subtarget assignments
)
1
cloned
No
lmo0146
16802194
-
hypothetical protein lmo0146 [Listeria m...
68
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91406
(
show subtarget assignments
)
8
cloned
No
VV1_0798
27364247
ADP-heptose--LPS heptosyltransferase II ...
352
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1PSW
50.3%
Vibrio vulnificus
IDP91407
(
show subtarget assignments
)
8
purified
No
VV1_0729
27364183
cAMP-binding proteins - catabolite gene ...
187
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3DN7
23.4%
Vibrio vulnificus
IDP91408
(
show subtarget assignments
)
8
soluble
No
VV1_0725
27364179
cysN
sulfate adenylyltransferase subunit 1 [V...
476
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1ZUN
54.8%
Vibrio vulnificus
IDP04066
(
show subtarget assignments
)
8
selected
No
CAC05819
12329088
mxiE
MxiE, similarities to transcriptional ac...
210
Shigella effector protein
Community Requests
Shigella flexneri
IDP05662
(
show subtarget assignments
)
1
soluble
No
lmo0303
16802349
-
putaive secreted, lysin rich protein [Li...
184
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP91413
(
show subtarget assignments
)
8
cloned
No
VV1_0714
27364169
hypothetical protein VV1_0714 [Vibrio vu...
69
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05275
(
show subtarget assignments
)
1
soluble
No
lmo2686
16804723
-
hypothetical protein lmo2686 [Listeria m...
177
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04652
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT1432c
56708477
ppnK
inorganic phosphate/ATP-NAD kinase [Fran...
296
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2AN1
41.6%
Francisella tularensis
IDP04555
(
show subtarget assignments
)
1
cloned
No
STM2272_1_878
16765599
gyrA
DNA gyrase subunit A [Salmonella typhimu...
878
Salmonella essential protein
Phase 4: April 2009
3NUH
57.7%
Salmonella enterica
IDP04554
(
show subtarget assignments
)
1
cloned
No
STM0791_1_506
16764154
hutH
histidine ammonia-lyase [Salmonella typh...
506
Salmonella essential protein
Phase 4: April 2009
1GK2
76.5%
Salmonella enterica
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP04559
(
show subtarget assignments
)
8
selected
No
CAC05871
12329140
ospE1
OspE1, secreted by the Mxi-Spa secretion...
88
Shigella effector protein
Community Requests
Shigella flexneri
IDP04558
(
show subtarget assignments
)
8
selected
No
CAC05811
12329080
mxiG
MxiG, component of the Mxi-Spa secretion...
371
Shigella effector protein
Community Requests
4A4Y
34%
Shigella flexneri
IDP04572
(
show subtarget assignments
)
1
soluble
No
BAS0005
49183044
DNA gyrase subunit B [Bacillus anthracis...
640
Proposed to be essential proteins
Phase 4: April 2009
1EI1
34.4%
Bacillus anthracis
IDP04650
(
show subtarget assignments
)
1
expressed
No
FTT1302
56708360
hypothetical protein FTT_1302 [Francisel...
276
drug target; conserved gene;
Phase 4: April 2009
3GBP
88.3%
Francisella tularensis
IDP91417
(
show subtarget assignments
)
8
in_pdb
3V4G
No
VV1_0674
27364131
arginine repressor [Vibrio vulnificus CM...
156
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3V4G
100%
Vibrio vulnificus
IDP04651
(
show subtarget assignments
)
1
cloned
No
FTT1417
56708464
carbon-nitrogen hydrolase [Francisella t...
261
drug target; conserved gene;
Phase 4: April 2009
2E11
34.3%
Francisella tularensis
IDP04571
(
show subtarget assignments
)
1
cloned
No
BAS0002
49183041
DNA polymerase III subunit beta [Bacillu...
379
Proposed to be essential proteins
Phase 4: April 2009
2AWA
42%
Bacillus anthracis
IDP04067
(
show subtarget assignments
)
1
purified
No
BAS4417
49187412
thioredoxin [Bacillus anthracis str. Ste...
104
Proposed to be essential proteins
Phase 4: April 2009
2GZY
75%
Bacillus anthracis
IDP04576
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0076
49183111
lysyl-tRNA synthetase [Bacillus anthraci...
499
Proposed to be essential proteins
Phase 4: April 2009
3A74
77.6%
Bacillus anthracis
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04578
(
show subtarget assignments
)
1
cloned
No
BAS0089
49183123
cysteinyl-tRNA synthetase [Bacillus anth...
465
Proposed to be essential proteins
Phase 4: April 2009
1LI5
45.6%
Bacillus anthracis
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP91421
(
show subtarget assignments
)
8
soluble
No
VV1_0568
27364030
NTP pyrophosphohydrolase [Vibrio vulnifi...
133
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1MUT
42.9%
Vibrio vulnificus
IDP04577
(
show subtarget assignments
)
1
cloned
No
BAS0087
49183121
glutamyl-tRNA synthetase [Bacillus anthr...
485
Proposed to be essential proteins
Phase 4: April 2009
2O5R
44.4%
Bacillus anthracis
IDP91842
(
show subtarget assignments
)
8
cloned
No
SPG_1268
194397142
positive transcriptional regulator MutRf...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91841
(
show subtarget assignments
)
8
selected
No
stu0182
55820280
MutR family transcriptional regulator [S...
238
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus thermophilus
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