Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02643 (show subtarget assignments)	1	in_pdb 3RUY	No	GBAA1154	47526421	rocD	ornithine--oxo-acid transaminase [Bacill...	396	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3RUY	98.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02647 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0537	16802580		allantoate amidohydrolase [Listeria mono...	423	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3N5F	38.1%	Listeria monocytogenes	Energy metabolism	Amino acids and amines

IDP02640 (show subtarget assignments)	1	purified	No	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0890	16764251	artI	arginine transport system [Salmonella ty...	243	Conserved; Drug target functions	Phase 3: June 2008	2Y7I	51.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01961 (show subtarget assignments)	1	soluble	No	STM1692	16765035	sapA	peptide transport protein [Salmonella ty...	549	Conserved; Drug target functions	Phase 3: June 2008	1DPP	34.1%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02381 (show subtarget assignments)	1	expressed	No	GBAA2279	47527580	proV-1	glycine betaine/L-proline ABC transporte...	315	Conserved; Drug target functions	Phase 3: June 2008	1Z47	36.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01411 (show subtarget assignments)	1	purified	No	VC1095	15641108		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	28%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01033 (show subtarget assignments)	1	soluble	No	STM3815	16767100	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01959 (show subtarget assignments)	1	soluble	No	STM1679	16765022	mppA	periplasmic murein tripeptide transport ...	537	Conserved; Drug target functions	Phase 3: June 2008	3O9P	89.2%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01410 (show subtarget assignments)	1	in_crystallization_trials	No	VC1091	15641104		oligopeptide ABC transporter, periplasmi...	543	Conserved Gene / Pathway	Phase 2: March 2008	2Z23	53.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP04198 (show subtarget assignments)	1	soluble	No	CPF_2555	110799167		oligopeptide/dipeptide ABC transporter, ...	580	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XOC	29.8%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00526 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01146 (show subtarget assignments)	1	cloned	No	BA_0235	30253735		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	26.8%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP00978 (show subtarget assignments)	1	purified	No	STM1951	16765289	yecC	putative amino-acid ABC transporter ATP-...	250	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00972 (show subtarget assignments)	1	expressed	No	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01149 (show subtarget assignments)	1	purified	No	BA_1195	30254908		oligopeptide ABC transporter, ATP-bindin...	311	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	30.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01147 (show subtarget assignments)	1	expressed	No	BA_0639	30254242		amino acid ABC transporter, ATP-binding ...	243	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	60.5%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01418 (show subtarget assignments)	1	purified	No	VC1424	15641435		spermidine/putrescine ABC transporter, p...	345	Conserved Gene / Pathway	Phase 2: March 2008	1POT	61.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01301 (show subtarget assignments)	1	expressed	No	VC0170	15640200		peptide ABC transporter, ATP-binding pro...	571	Conserved Gene / Pathway	Phase 2: March 2008	1YQT	22.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01768 (show subtarget assignments)	1	purified	No	YPO3633	16123775		putative periplasmic binding protein [Ye...	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...	Phase 3: June 2008	3D02	49.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00933 (show subtarget assignments)	1	purified	No	STM0662	16764039	gltL	glutamate/aspartate transporter	241	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00210 (show subtarget assignments)	1	crystallized	No	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01336 (show subtarget assignments)	1	purified	No	VC1428	15641439	potA	putrescine/spermidine ABC transporter AT...	377	Conserved Gene / Pathway	Phase 2: March 2008	2D62	41.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01145 (show subtarget assignments)	1	expressed	No	BA_0188	30253695		oligopeptide ABC transporter, ATP-bindin...	257	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	34.6%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP00203 (show subtarget assignments)	1	in_pdb 3T7B	No	YPO3925	16124056	argB	acetylglutamate kinase	257	Virulence	Phase 1: October 2007	3T7B	100%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02339 (show subtarget assignments)	1	expressed	No	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00475 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3808	16123942	livK	branched-chain amino acid-binding protei...	371	Virulence Associated Factor	Phase 2: March 2008	1USG	71.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00474 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2512	16122733	glnH	glutamine ABC transporter periplasmic pr...	247	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	78.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01395 (show subtarget assignments)	1	purified	No	VC0704	15640723		spermidine/putrescine ABC transporter, p...	359	Conserved Gene / Pathway	Phase 2: March 2008	3TTK	27.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01641 (show subtarget assignments)	1	cloned	No	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01427 (show subtarget assignments)	1	purified	No	VC1684	15641688		peptide ABC transporter, ATP-binding pro...	262	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	33.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP00428 (show subtarget assignments)	1	expressed	No	YPO2355	16122579	sapA	peptide transport periplasmic protein pr...	548	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	36.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02249 (show subtarget assignments)	1	expressed	No	YPO0955	16121258		hypothetical protein YPO0955 [Yersinia p...	323	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2R79	22%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02058 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0075	16120426	cpxP	periplasmic stress adaptor protein CpxP ...	162	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3ITF	41.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00421 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1331	16121613	potF	putrescine transporter subunit: periplas...	369	Virulence Associated Factor	Phase 2: March 2008	1A99	82.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01968 (show subtarget assignments)	1	purified	No	STM1954	16765292	fliY	cystine transporter subunit [Salmonella ...	266	Conserved; Drug target functions	Phase 3: June 2008	2YLN	35%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01687 (show subtarget assignments)	1	cloned	No	Cj0740	15792089		hypothetical protein Cj0740 [Campylobact...	54	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP01120 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02403 (show subtarget assignments)	1	expressed	No	Cj1024c	15792351		sigma-54 dependent DNA-binding response ...	433	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3DZD	36%	Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP01683 (show subtarget assignments)	1	expressed	No	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01699 (show subtarget assignments)	1	purified	No	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00738 (show subtarget assignments)	1	cloned	No	SACOL0994	57284368	oppF	oligopeptide ABC transporter, ATP-bindin...	313	Drug Target Function	Phase 2: March 2008	2YZ2	27.2%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00737 (show subtarget assignments)	1	expressed	No	SACOL0993	57284367	oppD	oligopeptide ABC transporter, ATP-bindin...	360	Drug Target Function	Phase 2: March 2008	1B0U	25%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01971 (show subtarget assignments)	1	soluble	No	STM3065	16766366	yggE	hypothetical protein STM3065 [Salmonella...	248	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00732 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2473	57286467		peptide ABC transporter, ATP-binding pro...	271	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	31.7%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00730 (show subtarget assignments)	1	soluble	No	SACOL2453	57286449		amino acid ABC transporter, ATP-binding ...	408	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	27.5%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP04270 (show subtarget assignments)	1	cloned	No	CPF_2226	110799081	potD	spermidine/putrescine ABC transporter, s...	360	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	4EQB	40.3%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP00715 (show subtarget assignments)	1	cloned	No	SACOL1414	57286065		peptide ABC transporter, ATP-binding pro...	233	Conserved Gene / Pathway	Phase 2: March 2008	3QF4	30.8%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00713 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1108	57285894		spermidine/putrescine ABC transporter, A...	364	Conserved Gene / Pathway	Phase 2: March 2008	2D62	40.4%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00712 (show subtarget assignments)	1	cloned	No	SACOL0998	57284372		oligopeptide ABC transporter, ATP-bindin...	326	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	29.1%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00711 (show subtarget assignments)	1	soluble	No	SACOL0997	57284371		oligopeptide ABC transporter, ATP-bindin...	328	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	26.8%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00696 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2410	57285141		amino acid ABC transporter, ATP-binding ...	243	Drug Target Function	Phase 2: March 2008	2OLJ	52.3%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01355 (show subtarget assignments)	1	soluble	No	VC0008	15640040		amino acid ABC transporter, ATP-binding ...	245	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	51.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01419 (show subtarget assignments)	1	in_crystallization_trials	No	VC1425	15641436		spermidine/putrescine ABC transporter, p...	366	Conserved Gene / Pathway	Phase 2: March 2008	1POT	52.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02029 (show subtarget assignments)	1	in_crystallization_trials	No	STM2844	16766150		hypothetical protein STM2844 [Salmonella...	269	Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01414 (show subtarget assignments)	1	purified	No	VC1359	15641371		amino acid ABC transporter, ATP-binding ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02198 (show subtarget assignments)	1	cloned	No	YPO1273	16121558		putative substrate-binding transport pro...	602	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1XOC	21.6%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP04113 (show subtarget assignments)	1	selected	No	YPO2627	115348319	glmD	putative glucosamine-6-phosphate isomera...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CD5	85.7%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04112 (show subtarget assignments)	1	cloned	No	YPO2626	115348318	nagA	putative N-acetylglucosamine-6-phosphate...	381	drug target; putative drug target function;	Phase 4: April 2009	1YMY	75.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP01927 (show subtarget assignments)	1	expressed	No	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP04718 (show subtarget assignments)	1	cloned	No	YPO0838	218928014		putative acetylglucosamine-6-phosphate d...	388	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2VHL	36.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP01334 (show subtarget assignments)	1	in_pdb 3IV8 3EGJ	Yes	VC0994	15641009	nagA	N-acetylglucosamine-6-phosphate deacetyl...	378	Drug Target Function	Phase 2: March 2008	3EGJ	100%	Vibrio cholerae	Central intermediary metabolism	Amino sugars

IDP04717 (show subtarget assignments)	1	cloned	No	YPO0832	218928008	agaZ	putative tagatose 6-phosphate kinase [Ye...	432	conserved gene; putative drug target function;	Phase 4: April 2009	2FIQ	51.6%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04473 (show subtarget assignments)	1	expressed	No	YPO2624	115348316	nagD	putative N-acetylglucosamine metabolism ...	250	conserved gene; putative drug target function;	Phase 4: April 2009	2C4N	86%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP01677 (show subtarget assignments)	1	soluble	No	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP00693 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2145	57286359	glmS	D-fructose-6-phosphate amidotransferase ...	601	Drug Target Function	Phase 2: March 2008	1JXA	41.4%	Staphylococcus aureus	Central intermediary metabolism	Amino sugars

IDP00340 (show subtarget assignments)	1	in_pdb 3TBF	No	FTT0388	56707537	glmS	Glucosamine--fructose-6-phosphate aminot...	612	Drug Target Function	Phase 2: March 2008	3TBF	60.8%	Francisella tularensis	Central intermediary metabolism	Amino sugars

IDP00657 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0761	57285726	nagA	N-acetylglucosamine-6-phosphate deacetyl...	393	Drug Target Function	Phase 2: March 2008	2VHL	45.8%	Staphylococcus aureus	Central intermediary metabolism	Amino sugars

IDP02603 (show subtarget assignments)	1	expressed	No	GBAA4274	47529567	nagA	N-acetylglucosamine-6-phosphate deacetyl...	380	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VHL	44%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP01908 (show subtarget assignments)	1	cloned	No	STM1392	16764742	ssrA	sensor kinase [Salmonella typhimurium LT...	920	Conserved; Drug target functions	Phase 3: June 2008	2C2A	7.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02006 (show subtarget assignments)	1	expressed	No	STM2285	16765612	glpB	anaerobic glycerol-3-phosphate dehydroge...	419	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Anaerobic

IDP02643
(show subtarget assignments)

1

in_pdb
3RUY

No

GBAA1154

47526421

rocD

ornithine--oxo-acid transaminase [Bacill...

396

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3RUY

98.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02647
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0537

16802580

allantoate amidohydrolase [Listeria mono...

423

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3N5F

38.1%

Listeria monocytogenes

Energy metabolism

Amino acids and amines

IDP02640
(show subtarget assignments)

1

purified

No

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0890

16764251

artI

arginine transport system [Salmonella ty...

243

Conserved; Drug target functions

Phase 3: June 2008

2Y7I

51.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01961
(show subtarget assignments)

1

soluble

No

STM1692

16765035

sapA

peptide transport protein [Salmonella ty...

549

Conserved; Drug target functions

Phase 3: June 2008

1DPP

34.1%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02381
(show subtarget assignments)

1

expressed

No

GBAA2279

47527580

proV-1

glycine betaine/L-proline ABC transporte...

315

Conserved; Drug target functions

Phase 3: June 2008

1Z47

36.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01411
(show subtarget assignments)

1

purified

No

VC1095

15641108

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

28%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01033
(show subtarget assignments)

1

soluble

No

STM3815

16767100

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01959
(show subtarget assignments)

1

soluble

No

STM1679

16765022

mppA

periplasmic murein tripeptide transport ...

537

Conserved; Drug target functions

Phase 3: June 2008

3O9P

89.2%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01410
(show subtarget assignments)

1

in_crystallization_trials

No

VC1091

15641104

oligopeptide ABC transporter, periplasmi...

543

Conserved Gene / Pathway

Phase 2: March 2008

2Z23

53.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP04198
(show subtarget assignments)

1

soluble

No

CPF_2555

110799167

oligopeptide/dipeptide ABC transporter, ...

580

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XOC

29.8%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00526
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01146
(show subtarget assignments)

1

cloned

No

BA_0235

30253735

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

26.8%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP00978
(show subtarget assignments)

1

purified

No

STM1951

16765289

yecC

putative amino-acid ABC transporter ATP-...

250

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00972
(show subtarget assignments)

1

expressed

No

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01149
(show subtarget assignments)

1

purified

No

BA_1195

30254908

oligopeptide ABC transporter, ATP-bindin...

311

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

30.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01147
(show subtarget assignments)

1

expressed

No

BA_0639

30254242

amino acid ABC transporter, ATP-binding ...

243

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

60.5%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01418
(show subtarget assignments)

1

purified

No

VC1424

15641435

spermidine/putrescine ABC transporter, p...

345

Conserved Gene / Pathway

Phase 2: March 2008

1POT

61.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01301
(show subtarget assignments)

1

expressed

No

VC0170

15640200

peptide ABC transporter, ATP-binding pro...

571

Conserved Gene / Pathway

Phase 2: March 2008

1YQT

22.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01768
(show subtarget assignments)

1

purified

No

YPO3633

16123775

putative periplasmic binding protein [Ye...

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...

Phase 3: June 2008

3D02

49.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00933
(show subtarget assignments)

1

purified

No

STM0662

16764039

gltL

glutamate/aspartate transporter

241

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00210
(show subtarget assignments)

1

crystallized

No

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01336
(show subtarget assignments)

1

purified

No

VC1428

15641439

potA

putrescine/spermidine ABC transporter AT...

377

Conserved Gene / Pathway

Phase 2: March 2008

2D62

41.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01145
(show subtarget assignments)

1

expressed

No

BA_0188

30253695

oligopeptide ABC transporter, ATP-bindin...

257

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

34.6%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP00203
(show subtarget assignments)

1

in_pdb
3T7B

No

YPO3925

16124056

argB

acetylglutamate kinase

257

Virulence

Phase 1: October 2007

3T7B

100%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02339
(show subtarget assignments)

1

expressed

No

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00475
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3808

16123942

livK

branched-chain amino acid-binding protei...

371

Virulence Associated Factor

Phase 2: March 2008

1USG

71.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00474
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2512

16122733

glnH

glutamine ABC transporter periplasmic pr...

247

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

78.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01395
(show subtarget assignments)

1

purified

No

VC0704

15640723

spermidine/putrescine ABC transporter, p...

359

Conserved Gene / Pathway

Phase 2: March 2008

3TTK

27.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01641
(show subtarget assignments)

1

cloned

No

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01427
(show subtarget assignments)

1

purified

No

VC1684

15641688

peptide ABC transporter, ATP-binding pro...

262

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

33.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP00428
(show subtarget assignments)

1

expressed

No

YPO2355

16122579

sapA

peptide transport periplasmic protein pr...

548

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

36.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02249
(show subtarget assignments)

1

expressed

No

YPO0955

16121258

hypothetical protein YPO0955 [Yersinia p...

323

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2R79

22%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02058
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0075

16120426

cpxP

periplasmic stress adaptor protein CpxP ...

162

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3ITF

41.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00421
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1331

16121613

potF

putrescine transporter subunit: periplas...

369

Virulence Associated Factor

Phase 2: March 2008

1A99

82.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01968
(show subtarget assignments)

1

purified

No

STM1954

16765292

fliY

cystine transporter subunit [Salmonella ...

266

Conserved; Drug target functions

Phase 3: June 2008

2YLN

35%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01687
(show subtarget assignments)

1

cloned

No

Cj0740

15792089

hypothetical protein Cj0740 [Campylobact...

54

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP01120
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02403
(show subtarget assignments)

1

expressed

No

Cj1024c

15792351

sigma-54 dependent DNA-binding response ...

433

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3DZD

36%

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP01683
(show subtarget assignments)

1

expressed

No

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01699
(show subtarget assignments)

1

purified

No

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00738
(show subtarget assignments)

1

cloned

No

SACOL0994

57284368

oppF

oligopeptide ABC transporter, ATP-bindin...

313

Drug Target Function

Phase 2: March 2008

2YZ2

27.2%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00737
(show subtarget assignments)

1

expressed

No

SACOL0993

57284367

oppD

oligopeptide ABC transporter, ATP-bindin...

360

Drug Target Function

Phase 2: March 2008

1B0U

25%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01971
(show subtarget assignments)

1

soluble

No

STM3065

16766366

yggE

hypothetical protein STM3065 [Salmonella...

248

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00732
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2473

57286467

peptide ABC transporter, ATP-binding pro...

271

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

31.7%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00730
(show subtarget assignments)

1

soluble

No

SACOL2453

57286449

amino acid ABC transporter, ATP-binding ...

408

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

27.5%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP04270
(show subtarget assignments)

1

cloned

No

CPF_2226

110799081

potD

spermidine/putrescine ABC transporter, s...

360

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

4EQB

40.3%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP00715
(show subtarget assignments)

1

cloned

No

SACOL1414

57286065

peptide ABC transporter, ATP-binding pro...

233

Conserved Gene / Pathway

Phase 2: March 2008

3QF4

30.8%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00713
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1108

57285894

spermidine/putrescine ABC transporter, A...

364

Conserved Gene / Pathway

Phase 2: March 2008

2D62

40.4%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00712
(show subtarget assignments)

1

cloned

No

SACOL0998

57284372

oligopeptide ABC transporter, ATP-bindin...

326

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

29.1%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00711
(show subtarget assignments)

1

soluble

No

SACOL0997

57284371

oligopeptide ABC transporter, ATP-bindin...

328

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

26.8%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00696
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2410

57285141

amino acid ABC transporter, ATP-binding ...

243

Drug Target Function

Phase 2: March 2008

2OLJ

52.3%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01355
(show subtarget assignments)

1

soluble

No

VC0008

15640040

amino acid ABC transporter, ATP-binding ...

245

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

51.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01419
(show subtarget assignments)

1

in_crystallization_trials

No

VC1425

15641436

spermidine/putrescine ABC transporter, p...

366

Conserved Gene / Pathway

Phase 2: March 2008

1POT

52.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02029
(show subtarget assignments)

1

in_crystallization_trials

No

STM2844

16766150

hypothetical protein STM2844 [Salmonella...

269

Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01414
(show subtarget assignments)

1

purified

No

VC1359

15641371

amino acid ABC transporter, ATP-binding ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02198
(show subtarget assignments)

1

cloned

No

YPO1273

16121558

putative substrate-binding transport pro...

602

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1XOC

21.6%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP04113
(show subtarget assignments)

1

selected

No

YPO2627

115348319

glmD

putative glucosamine-6-phosphate isomera...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CD5

85.7%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04112
(show subtarget assignments)

1

cloned

No

YPO2626

115348318

nagA

putative N-acetylglucosamine-6-phosphate...

381

drug target; putative drug target function;

Phase 4: April 2009

1YMY

75.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP01927
(show subtarget assignments)

1

expressed

No

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP04718
(show subtarget assignments)

1

cloned

No

YPO0838

218928014

putative acetylglucosamine-6-phosphate d...

388

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2VHL

36.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP01334
(show subtarget assignments)

1

in_pdb
3IV8
3EGJ

Yes

VC0994

15641009

nagA

N-acetylglucosamine-6-phosphate deacetyl...

378

Drug Target Function

Phase 2: March 2008

3EGJ

100%

Vibrio cholerae

Central intermediary metabolism

Amino sugars

IDP04717
(show subtarget assignments)

1

cloned

No

YPO0832

218928008

agaZ

putative tagatose 6-phosphate kinase [Ye...

432

conserved gene; putative drug target function;

Phase 4: April 2009

2FIQ

51.6%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04473
(show subtarget assignments)

1

expressed

No

YPO2624

115348316

nagD

putative N-acetylglucosamine metabolism ...

250

conserved gene; putative drug target function;

Phase 4: April 2009

2C4N

86%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP01677
(show subtarget assignments)

1

soluble

No

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP00693
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2145

57286359

glmS

D-fructose-6-phosphate amidotransferase ...

601

Drug Target Function

Phase 2: March 2008

1JXA

41.4%

Staphylococcus aureus

Central intermediary metabolism

Amino sugars

IDP00340
(show subtarget assignments)

1

in_pdb
3TBF

No

FTT0388

56707537

glmS

Glucosamine--fructose-6-phosphate aminot...

612

Drug Target Function

Phase 2: March 2008

3TBF

60.8%

Francisella tularensis

Central intermediary metabolism

Amino sugars

IDP00657
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0761

57285726

nagA

N-acetylglucosamine-6-phosphate deacetyl...

393

Drug Target Function

Phase 2: March 2008

2VHL

45.8%

Staphylococcus aureus

Central intermediary metabolism

Amino sugars

IDP02603
(show subtarget assignments)

1

expressed

No

GBAA4274

47529567

nagA

N-acetylglucosamine-6-phosphate deacetyl...

380

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VHL

44%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP01908
(show subtarget assignments)

1

cloned

No

STM1392

16764742

ssrA

sensor kinase [Salmonella typhimurium LT...

920

Conserved; Drug target functions

Phase 3: June 2008

2C2A

7.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02006
(show subtarget assignments)

1

expressed

No

STM2285

16765612

glpB

anaerobic glycerol-3-phosphate dehydroge...

419

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Anaerobic

Targets