Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05156 (show subtarget assignments)	1	soluble	No	BA_1093	30254823		putative S-layer protein [Bacillus anthr...	344	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	26.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP04574 (show subtarget assignments)	1	soluble	No	BAS0015	49183051		seryl-tRNA synthetase [Bacillus anthraci...	424	Proposed to be essential proteins	Phase 4: April 2009	2DQ3	57.8%	Bacillus anthracis

IDP05196 (show subtarget assignments)	1	cloned	No	CD0961	126698545		putative phage cell wall hydrolase [Clos...	656	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	8.1%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP05251 (show subtarget assignments)	1	cloned	No	lmo2747	16804784	serS	seryl-tRNA synthetase [Listeria monocyto...	427	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	56.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05011 (show subtarget assignments)	1	soluble	No	BA_4970	30259463		hypothetical protein BA_4970 [Bacillus a...	139	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP05217 (show subtarget assignments)	1	in_crystallization_trials	No	CD3421	126701044	hemC	porphobilinogen deaminase [Clostridium d...	301	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PDA	37.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04314 (show subtarget assignments)	1	purified	No	YPCD1.73c	5832493	YPCD1.73c	hypothetical protein YPCD1.73c [Yersinia...	149	virulence factor; conserved gene;	Phase 4: April 2009	1JSC	40.7%	Yersinia pestis

IDP04417 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0033	56707213	nuoC	NADH dehydrogenase I [Francisella tulare...	216	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2FUG	21.8%	Francisella tularensis

IDP05018 (show subtarget assignments)	1	purified	No	BA_2679	30257293		hypothetical protein BA_2679 [Bacillus a...	47	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04340 (show subtarget assignments)	1	cloned	No	BAS0122	49183156		50S ribosomal protein L5 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1IQ4	85.5%	Bacillus anthracis

IDP05014 (show subtarget assignments)	1	soluble	No	BA_1972	30256627		putative lipoprotein [Bacillus anthracis...	765	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05195 (show subtarget assignments)	1	soluble	No	CD0873	126698450		ABC transporter, substrate-binding lipop...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LKV	32.9%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP04658 (show subtarget assignments)	1	purified	No	FTT1736c	56708739	kdpD	two component sensor protein kdpD [Franc...	893	conserved gene;	Phase 4: April 2009	2R8R	11.4%	Francisella tularensis

IDP05311 (show subtarget assignments)	1	cloned	No	CD3014	126700634		PTS system, IIB component [Clostridium d...	106	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2R4Q	45.3%	Clostridium difficile	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP04326 (show subtarget assignments)	8	purified	No	CAC05800	12329069	ipaA	IpaA, secreted by the Mxi-Spa machinery,...	633	Shigella effector protein	Community Requests	2FM8	10.7%	Shigella flexneri

IDP05305 (show subtarget assignments)	1	cloned	No	CD2986	126700607	bacA2	undecaprenyl pyrophosphate phosphatase [...	283	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05357 (show subtarget assignments)	1	soluble	No	BA_0382	30253917		putative ABC transporter, substrate-bind...	332	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	25.9%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05602 (show subtarget assignments)	1	cloned	No	BA_4347	30258847		putative lipase/acylhydrolase [Bacillus ...	259	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP05303 (show subtarget assignments)	1	cloned	No	SACOL1685	57650511	aspS	aspartyl-tRNA synthetase [Staphylococcus...	588	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1C0A	54.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05067 (show subtarget assignments)	1	cloned	No	CD2664	126700278	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	484	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2WTZ	36.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04339 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0115	49183149		50S ribosomal protein L22 [Bacillus anth...	113	Proposed to be essential proteins	Phase 4: April 2009	1BXE	59.3%	Bacillus anthracis

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP04336 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05790	12329059	ospC1	OspC1, secreted by the Mxi-Spa secretion...	470	Shigella effector protein	Community Requests			Shigella flexneri

IDP05216 (show subtarget assignments)	1	cloned	No	CD3349	126700969	bclA3	putative exosporium glycoprotein [Clostr...	657	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.6%	Clostridium difficile	Unknown function: General

IDP04573 (show subtarget assignments)	1	crystallized	No	BAS0006	49183045		DNA gyrase subunit A [Bacillus anthracis...	823	Proposed to be essential proteins	Phase 4: April 2009	2XCO	42.9%	Bacillus anthracis

IDP05137 (show subtarget assignments)	1	soluble	No	CD0227	126697798		hypothetical protein CD0227 [Clostridium...	142	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2QUP	26.4%	Clostridium difficile	Hypothetical proteins: Conserved

IDP05053 (show subtarget assignments)	1	expressed	No	CD0242	126697813		hypothetical protein CD0242 [Clostridium...	214	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3D5N	18.7%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP04652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1432c	56708477	ppnK	inorganic phosphate/ATP-NAD kinase [Fran...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2AN1	41.6%	Francisella tularensis

IDP05168 (show subtarget assignments)	1	cloned	No	BA_1926	30256584		putative S-layer protein [Bacillus anthr...	331	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	17.5%	Bacillus anthracis	Cell envelope: Surface structures

IDP04414 (show subtarget assignments)	8	selected	No	CAC05786	12329055	sepA	SepA, extracellular serine protease of t...	1364	Shigella effector protein	Community Requests	1WXR	34.9%	Shigella flexneri

IDP05012 (show subtarget assignments)	1	cloned	No	BA_5070	30259559		cell wall surface anchor family protein ...	148	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP04597 (show subtarget assignments)	1	expressed	No	BAS1384	49184401		resB protein [Bacillus anthracis str. St...	541	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP05055 (show subtarget assignments)	1	cloned	No	CD0253	126697824	fliK	putative flagellar hook-length control p...	401	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05052 (show subtarget assignments)	1	expressed	No	CD0239	126697810	fliC	flagellin subunit [Clostridium difficile...	290	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3K8W	34.8%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05306 (show subtarget assignments)	1	cloned	No	CD2786	126700402		cell surface protein [Clostridium diffic...	525	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP05310 (show subtarget assignments)	1	soluble	No	CD0844	126698424		cell surface protein [Clostridium diffic...	313	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP04349 (show subtarget assignments)	1	expressed	No	STM0557_1_550	16763935		putative inner membrane protein [Salmone...	550	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04350 (show subtarget assignments)	1	cloned	No	STM1338_1_795	16764689	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Salmonella essential protein	Phase 4: April 2009	3PCO	92.6%	Salmonella enterica

IDP05140 (show subtarget assignments)	1	soluble	No	BAS0382	49183410	-	prolyl-tRNA synthetase [Bacillus anthrac...	508	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H4Q	48.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05054 (show subtarget assignments)	1	cloned	No	CD0250	126697821	fliH	flagellar assembly protein [Clostridium ...	243	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04588 (show subtarget assignments)	1	cloned	No	BAS0130	49183164		preprotein translocase subunit SecY [Bac...	433	Proposed to be essential proteins	Phase 4: April 2009	3DIN	43.8%	Bacillus anthracis

IDP04367 (show subtarget assignments)	1	cloned	No	BAS3563	49186564		PTS system, fructose-specific IIABC comp...	622	Proposed to be essential proteins	Phase 4: April 2009	2R4Q	11.4%	Bacillus anthracis

IDP05142 (show subtarget assignments)	1	cloned	No	BAS2027	49185038	-	isoleucyl-tRNA synthetase [Bacillus anth...	1033	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ILE	38.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP04368 (show subtarget assignments)	1	selected	No	BAS3746	49186745		isoleucyl-tRNA synthetase [Bacillus anth...	921	Proposed to be essential proteins	Phase 4: April 2009	1FFY	63.3%	Bacillus anthracis

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP05147 (show subtarget assignments)	1	cloned	No	BAS4903	49187891	-	methionyl-tRNA synthetase [Bacillus anth...	544	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RQG	38.7%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05139 (show subtarget assignments)	1	soluble	No	BAS0353	49183381	-	amino acid ABC transporter, solute bindi...	264	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQL	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05141 (show subtarget assignments)	1	cloned	No	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP04654 (show subtarget assignments)	1	purified	No	FTT1526c	56708560	idh	isocitrate dehydrogenase [Francisella tu...	747	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ITW	62.7%	Francisella tularensis

IDP05205 (show subtarget assignments)	1	cloned	No	CD1770	126699379	ogt2	methylated-DNA--protein-cysteine methylt...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2G7H	32.3%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP05138 (show subtarget assignments)	1	cloned	No	CD2874	126700490		putative drug/sodium antiporter [Clostri...	446	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010			Clostridium difficile	Transport and binding proteins: Other

IDP05307 (show subtarget assignments)	1	cloned	No	YPO0362	16120697	-	lysyl-tRNA synthetase [Yersinia pestis C...	325	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3A5Y	84%	Yersinia pestis	Unknown function: General

IDP05393 (show subtarget assignments)	1	expressed	No	BA_3225	30257788		hypothetical protein BA_3225 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05461 (show subtarget assignments)	1	selected	No	BA_1618	30255916		conserved repeat domain protein [Bacillu...	5017	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP05083 (show subtarget assignments)	1	cloned	No	lmo2444	16804482	-	hypothetical protein lmo2444 [Listeria m...	1310	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LPO	13.1%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP05219 (show subtarget assignments)	1	cloned	No	CD3567	126701193		putative cell wall hydrolase [Clostridiu...	516	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Sporulation and germination

IDP05157 (show subtarget assignments)	1	soluble	No	BA_1191	30254904		oligopeptide ABC transporter, oligopepti...	543	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05433 (show subtarget assignments)	1	soluble	No	lmo1730	16803770	-	hypothetical protein lmo1730 [Listeria m...	414	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3UOR	33.6%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05250 (show subtarget assignments)	1	soluble	No	lmo2446	16804484	-	hypothetical protein lmo2446 [Listeria m...	1091	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X2H	19%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP05312 (show subtarget assignments)	1	soluble	No	CD0895	126698472		metallo-beta-lactamase superfamily expor...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP04590 (show subtarget assignments)	1	expressed	No	BAS0136	49183170		30S ribosomal protein S11 [Bacillus anth...	129	Proposed to be essential proteins	Phase 4: April 2009	1VS5	65.9%	Bacillus anthracis

IDP05017 (show subtarget assignments)	1	cloned	No	BA_2521	30257145		putative lipoprotein [Bacillus anthracis...	52	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05066 (show subtarget assignments)	1	cloned	No	CD2654	126700268	mraY	phospho-N-acetylmuramoyl-pentapeptide-tr...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05417 (show subtarget assignments)	1	purified	No	BA_4788	30259274		conserved domain protein [Bacillus anthr...	152	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3SIK	82.9%	Bacillus anthracis	Hypothetical proteins: Domain

IDP05323 (show subtarget assignments)	1	cloned	No	lmo1275	16803315	topA	DNA topoisomerase I [Listeria monocytoge...	692	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2GAI	38.4%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP04592 (show subtarget assignments)	1	expressed	No	BAS0143	49183177		50S ribosomal protein L13 [Bacillus anth...	145	Proposed to be essential proteins	Phase 4: April 2009	1P85	56.6%	Bacillus anthracis

IDP05313 (show subtarget assignments)	1	soluble	No	BA_1061	30254794		putative lipoprotein [Bacillus anthracis...	274	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05392 (show subtarget assignments)	1	cloned	No	BA_3222	30257786		hypothetical protein BA_3222 [Bacillus a...	56	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05389 (show subtarget assignments)	1	cloned	No	BA_2660	30257276		hypothetical protein BA_2660 [Bacillus a...	31	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05060 (show subtarget assignments)	1	in_pdb 4DD5	Yes	CD1059	126698643	thlA1	acetyl-CoA acetyltransferase [Clostridiu...	396	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	4DD5	100%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05144 (show subtarget assignments)	1	soluble	No	BAS4556	49187550	-	tyrosyl-tRNA synthetase [Bacillus anthra...	418	Known drug target or ortholog of known drug target	Phase 5: 2010	2TS1	70.6%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05432 (show subtarget assignments)	1	cloned	No	BA_2714	30257323		hypothetical protein BA_2714 [Bacillus a...	31	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04381 (show subtarget assignments)	8	selected	No	CAC05791	12329060		unnamed protein product [Shigella flexne...	296	Shigella effector protein	Community Requests	3MKL	8.4%	Shigella flexneri

IDP05146 (show subtarget assignments)	1	cloned	No	BAS4784	49187774	-	glycyl-tRNA synthetase [Bacillus anthrac...	458	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	43.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05319 (show subtarget assignments)	1	soluble	No	BA_2848	30257448		putative oligopeptide ABC transporter, o...	540	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z23	29.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05354 (show subtarget assignments)	1	soluble	No	CD3043	126700661		hypothetical protein CD3043 [Clostridium...	342	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP04380 (show subtarget assignments)	1	cloned	No	STM3713_1_404	16766998	rfaL	O-antigen ligase [Salmonella typhimurium...	404	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05059 (show subtarget assignments)	1	soluble	No	CD0690	126698269		putative nucleotide phosphodiesterase [C...	655	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GVE	15.3%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP05057 (show subtarget assignments)	1	cloned	No	CD0266	126697838	fliA	RNA polymerase sigma factor for flagella...	233	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	38.2%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04395 (show subtarget assignments)	1	cloned	No	FTT0076	56707255	sucA	2-oxoglutarate dehydrogenase E1 componen...	941	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2JGD	47.8%	Francisella tularensis

IDP05315 (show subtarget assignments)	1	cloned	No	BAS0383	49183411	-	cell wall anchor domain-containing prote...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	23.6%	Bacillus anthracis	Cell envelope: Other

IDP05145 (show subtarget assignments)	1	soluble	No	BAS4679	49187670	-	hypothetical protein BAS4679 [Bacillus a...	357	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05317 (show subtarget assignments)	1	cloned	No	lmo0638	16802680	-	hypothetical protein lmo0638 [Listeria m...	209	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05318 (show subtarget assignments)	1	soluble	No	lmo0697	16802739	-	flagellar hook protein FlgE [Listeria mo...	411	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A69	30.6%	Listeria monocytogenes	Cellular processes: Chemotaxis and motility

IDP04383 (show subtarget assignments)	1	purified	No	BAS4455	49187450		phenylalanyl-tRNA synthetase subunit bet...	806	Proposed to be essential proteins	Phase 4: April 2009	2RHS	49.8%	Bacillus anthracis

IDP05143 (show subtarget assignments)	1	cloned	No	BAS4423	49187418	-	triple helix repeat-containing collagen ...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WCK	27.6%	Bacillus anthracis	Unknown function: General

IDP05081 (show subtarget assignments)	1	expressed	No	lmo2027	16804066	-	putative cell surface protein, internali...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y5Q	23.2%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05324 (show subtarget assignments)	1	cloned	No	CD3431	126701054		putative cobalamin biosynthesis kinase [...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VIS	24.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05167 (show subtarget assignments)	1	purified	No	lmo1333	16803373	-	hypothetical protein lmo1333 [Listeria m...	153	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP05065 (show subtarget assignments)	1	soluble	No	CD2469	126700086	spoIIP	putative stage II sporulation protein P ...	339	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cellular processes: Sporulation and germination

IDP05082 (show subtarget assignments)	1	cloned	No	lmo2179	16804218	-	peptidoglycan binding protein [Listeria ...	1152	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KT7	2.3%	Listeria monocytogenes	Regulatory functions: Other

IDP05322 (show subtarget assignments)	1	cloned	No	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05016 (show subtarget assignments)	1	soluble	No	BA_2056	30256706		putative lipoprotein [Bacillus anthracis...	59	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04396 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4797	49187787		pyridine nucleotide-disulphide oxidoredu...	331	Proposed to be essential proteins	Phase 4: April 2009	3LZW	76.7%	Bacillus anthracis

IDP90992 (show subtarget assignments)	8	cloned	No	y1333	22125232		DNA-binding transcriptional regulator Is...	185	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	3T8R	25.4%	Yersinia pestis

IDP90991 (show subtarget assignments)	8	cloned	No	y1282	22125182		formate acetyltransferase [Yersinia pest...	150	other biological interest / stress-response protein replacind PflA in PflA/PflB complex	Community Requests	1CM5	40%	Yersinia pestis

IDP05156
(show subtarget assignments)

1

soluble

No

BA_1093

30254823

putative S-layer protein [Bacillus anthr...

344

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

26.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP04574
(show subtarget assignments)

1

soluble

No

BAS0015

49183051

seryl-tRNA synthetase [Bacillus anthraci...

424

Proposed to be essential proteins

Phase 4: April 2009

2DQ3

57.8%

Bacillus anthracis

IDP05196
(show subtarget assignments)

1

cloned

No

CD0961

126698545

putative phage cell wall hydrolase [Clos...

656

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

8.1%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP05251
(show subtarget assignments)

1

cloned

No

lmo2747

16804784

serS

seryl-tRNA synthetase [Listeria monocyto...

427

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

56.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05011
(show subtarget assignments)

1

soluble

No

BA_4970

30259463

hypothetical protein BA_4970 [Bacillus a...

139

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP05217
(show subtarget assignments)

1

in_crystallization_trials

No

CD3421

126701044

hemC

porphobilinogen deaminase [Clostridium d...

301

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PDA

37.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04314
(show subtarget assignments)

1

purified

No

YPCD1.73c

5832493

YPCD1.73c

hypothetical protein YPCD1.73c [Yersinia...

149

virulence factor; conserved gene;

Phase 4: April 2009

1JSC

40.7%

Yersinia pestis

IDP04417
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0033

56707213

nuoC

NADH dehydrogenase I [Francisella tulare...

216

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2FUG

21.8%

Francisella tularensis

IDP05018
(show subtarget assignments)

1

purified

No

BA_2679

30257293

hypothetical protein BA_2679 [Bacillus a...

47

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04340
(show subtarget assignments)

1

cloned

No

BAS0122

49183156

50S ribosomal protein L5 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1IQ4

85.5%

Bacillus anthracis

IDP05014
(show subtarget assignments)

1

soluble

No

BA_1972

30256627

putative lipoprotein [Bacillus anthracis...

765

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05195
(show subtarget assignments)

1

soluble

No

CD0873

126698450

ABC transporter, substrate-binding lipop...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LKV

32.9%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP04658
(show subtarget assignments)

1

purified

No

FTT1736c

56708739

kdpD

two component sensor protein kdpD [Franc...

893

conserved gene;

Phase 4: April 2009

2R8R

11.4%

Francisella tularensis

IDP05311
(show subtarget assignments)

1

cloned

No

CD3014

126700634

PTS system, IIB component [Clostridium d...

106

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2R4Q

45.3%

Clostridium difficile

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP04326
(show subtarget assignments)

8

purified

No

CAC05800

12329069

ipaA

IpaA, secreted by the Mxi-Spa machinery,...

633

Shigella effector protein

Community Requests

2FM8

10.7%

Shigella flexneri

IDP05305
(show subtarget assignments)

1

cloned

No

CD2986

126700607

bacA2

undecaprenyl pyrophosphate phosphatase [...

283

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05357
(show subtarget assignments)

1

soluble

No

BA_0382

30253917

putative ABC transporter, substrate-bind...

332

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

25.9%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05602
(show subtarget assignments)

1

cloned

No

BA_4347

30258847

putative lipase/acylhydrolase [Bacillus ...

259

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP05303
(show subtarget assignments)

1

cloned

No

SACOL1685

57650511

aspS

aspartyl-tRNA synthetase [Staphylococcus...

588

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1C0A

54.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05067
(show subtarget assignments)

1

cloned

No

CD2664

126700278

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

484

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2WTZ

36.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04339
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0115

49183149

50S ribosomal protein L22 [Bacillus anth...

113

Proposed to be essential proteins

Phase 4: April 2009

1BXE

59.3%

Bacillus anthracis

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP04336
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05790

12329059

ospC1

OspC1, secreted by the Mxi-Spa secretion...

470

Shigella effector protein

Community Requests

Shigella flexneri

IDP05216
(show subtarget assignments)

1

cloned

No

CD3349

126700969

bclA3

putative exosporium glycoprotein [Clostr...

657

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.6%

Clostridium difficile

Unknown function: General

IDP04573
(show subtarget assignments)

1

crystallized

No

BAS0006

49183045

DNA gyrase subunit A [Bacillus anthracis...

823

Proposed to be essential proteins

Phase 4: April 2009

2XCO

42.9%

Bacillus anthracis

IDP05137
(show subtarget assignments)

1

soluble

No

CD0227

126697798

hypothetical protein CD0227 [Clostridium...

142

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2QUP

26.4%

Clostridium difficile

Hypothetical proteins: Conserved

IDP05053
(show subtarget assignments)

1

expressed

No

CD0242

126697813

hypothetical protein CD0242 [Clostridium...

214

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3D5N

18.7%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP04652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1432c

56708477

ppnK

inorganic phosphate/ATP-NAD kinase [Fran...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2AN1

41.6%

Francisella tularensis

IDP05168
(show subtarget assignments)

1

cloned

No

BA_1926

30256584

putative S-layer protein [Bacillus anthr...

331

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

17.5%

Bacillus anthracis

Cell envelope: Surface structures

IDP04414
(show subtarget assignments)

8

selected

No

CAC05786

12329055

sepA

SepA, extracellular serine protease of t...

1364

Shigella effector protein

Community Requests

1WXR

34.9%

Shigella flexneri

IDP05012
(show subtarget assignments)

1

cloned

No

BA_5070

30259559

cell wall surface anchor family protein ...

148

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP04597
(show subtarget assignments)

1

expressed

No

BAS1384

49184401

resB protein [Bacillus anthracis str. St...

541

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP05055
(show subtarget assignments)

1

cloned

No

CD0253

126697824

fliK

putative flagellar hook-length control p...

401

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05052
(show subtarget assignments)

1

expressed

No

CD0239

126697810

fliC

flagellin subunit [Clostridium difficile...

290

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3K8W

34.8%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05306
(show subtarget assignments)

1

cloned

No

CD2786

126700402

cell surface protein [Clostridium diffic...

525

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP05310
(show subtarget assignments)

1

soluble

No

CD0844

126698424

cell surface protein [Clostridium diffic...

313

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP04349
(show subtarget assignments)

1

expressed

No

STM0557_1_550

16763935

putative inner membrane protein [Salmone...

550

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04350
(show subtarget assignments)

1

cloned

No

STM1338_1_795

16764689

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Salmonella essential protein

Phase 4: April 2009

3PCO

92.6%

Salmonella enterica

IDP05140
(show subtarget assignments)

1

soluble

No

BAS0382

49183410

-

prolyl-tRNA synthetase [Bacillus anthrac...

508

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H4Q

48.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05054
(show subtarget assignments)

1

cloned

No

CD0250

126697821

fliH

flagellar assembly protein [Clostridium ...

243

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04588
(show subtarget assignments)

1

cloned

No

BAS0130

49183164

preprotein translocase subunit SecY [Bac...

433

Proposed to be essential proteins

Phase 4: April 2009

3DIN

43.8%

Bacillus anthracis

IDP04367
(show subtarget assignments)

1

cloned

No

BAS3563

49186564

PTS system, fructose-specific IIABC comp...

622

Proposed to be essential proteins

Phase 4: April 2009

2R4Q

11.4%

Bacillus anthracis

IDP05142
(show subtarget assignments)

1

cloned

No

BAS2027

49185038

-

isoleucyl-tRNA synthetase [Bacillus anth...

1033

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ILE

38.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP04368
(show subtarget assignments)

1

selected

No

BAS3746

49186745

isoleucyl-tRNA synthetase [Bacillus anth...

921

Proposed to be essential proteins

Phase 4: April 2009

1FFY

63.3%

Bacillus anthracis

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP05147
(show subtarget assignments)

1

cloned

No

BAS4903

49187891

-

methionyl-tRNA synthetase [Bacillus anth...

544

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RQG

38.7%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05139
(show subtarget assignments)

1

soluble

No

BAS0353

49183381

-

amino acid ABC transporter, solute bindi...

264

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQL

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05141
(show subtarget assignments)

1

cloned

No

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP04654
(show subtarget assignments)

1

purified

No

FTT1526c

56708560

idh

isocitrate dehydrogenase [Francisella tu...

747

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ITW

62.7%

Francisella tularensis

IDP05205
(show subtarget assignments)

1

cloned

No

CD1770

126699379

ogt2

methylated-DNA--protein-cysteine methylt...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2G7H

32.3%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP05138
(show subtarget assignments)

1

cloned

No

CD2874

126700490

putative drug/sodium antiporter [Clostri...

446

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

Clostridium difficile

Transport and binding proteins: Other

IDP05307
(show subtarget assignments)

1

cloned

No

YPO0362

16120697

-

lysyl-tRNA synthetase [Yersinia pestis C...

325

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3A5Y

84%

Yersinia pestis

Unknown function: General

IDP05393
(show subtarget assignments)

1

expressed

No

BA_3225

30257788

hypothetical protein BA_3225 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05461
(show subtarget assignments)

1

selected

No

BA_1618

30255916

conserved repeat domain protein [Bacillu...

5017

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP05083
(show subtarget assignments)

1

cloned

No

lmo2444

16804482

-

hypothetical protein lmo2444 [Listeria m...

1310

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LPO

13.1%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP05219
(show subtarget assignments)

1

cloned

No

CD3567

126701193

putative cell wall hydrolase [Clostridiu...

516

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Sporulation and germination

IDP05157
(show subtarget assignments)

1

soluble

No

BA_1191

30254904

oligopeptide ABC transporter, oligopepti...

543

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05433
(show subtarget assignments)

1

soluble

No

lmo1730

16803770

-

hypothetical protein lmo1730 [Listeria m...

414

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3UOR

33.6%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05250
(show subtarget assignments)

1

soluble

No

lmo2446

16804484

-

hypothetical protein lmo2446 [Listeria m...

1091

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X2H

19%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP05312
(show subtarget assignments)

1

soluble

No

CD0895

126698472

metallo-beta-lactamase superfamily expor...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP04590
(show subtarget assignments)

1

expressed

No

BAS0136

49183170

30S ribosomal protein S11 [Bacillus anth...

129

Proposed to be essential proteins

Phase 4: April 2009

1VS5

65.9%

Bacillus anthracis

IDP05017
(show subtarget assignments)

1

cloned

No

BA_2521

30257145

putative lipoprotein [Bacillus anthracis...

52

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05066
(show subtarget assignments)

1

cloned

No

CD2654

126700268

mraY

phospho-N-acetylmuramoyl-pentapeptide-tr...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05417
(show subtarget assignments)

1

purified

No

BA_4788

30259274

conserved domain protein [Bacillus anthr...

152

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3SIK

82.9%

Bacillus anthracis

Hypothetical proteins: Domain

IDP05323
(show subtarget assignments)

1

cloned

No

lmo1275

16803315

topA

DNA topoisomerase I [Listeria monocytoge...

692

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2GAI

38.4%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP04592
(show subtarget assignments)

1

expressed

No

BAS0143

49183177

50S ribosomal protein L13 [Bacillus anth...

145

Proposed to be essential proteins

Phase 4: April 2009

1P85

56.6%

Bacillus anthracis

IDP05313
(show subtarget assignments)

1

soluble

No

BA_1061

30254794

putative lipoprotein [Bacillus anthracis...

274

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05392
(show subtarget assignments)

1

cloned

No

BA_3222

30257786

hypothetical protein BA_3222 [Bacillus a...

56

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05389
(show subtarget assignments)

1

cloned

No

BA_2660

30257276

hypothetical protein BA_2660 [Bacillus a...

31

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05060
(show subtarget assignments)

1

in_pdb
4DD5

Yes

CD1059

126698643

thlA1

acetyl-CoA acetyltransferase [Clostridiu...

396

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

4DD5

100%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05144
(show subtarget assignments)

1

soluble

No

BAS4556

49187550

-

tyrosyl-tRNA synthetase [Bacillus anthra...

418

Known drug target or ortholog of known drug target

Phase 5: 2010

2TS1

70.6%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05432
(show subtarget assignments)

1

cloned

No

BA_2714

30257323

hypothetical protein BA_2714 [Bacillus a...

31

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04381
(show subtarget assignments)

8

selected

No

CAC05791

12329060

unnamed protein product [Shigella flexne...

296

Shigella effector protein

Community Requests

3MKL

8.4%

Shigella flexneri

IDP05146
(show subtarget assignments)

1

cloned

No

BAS4784

49187774

-

glycyl-tRNA synthetase [Bacillus anthrac...

458

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

43.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05319
(show subtarget assignments)

1

soluble

No

BA_2848

30257448

putative oligopeptide ABC transporter, o...

540

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z23

29.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05354
(show subtarget assignments)

1

soluble

No

CD3043

126700661

hypothetical protein CD3043 [Clostridium...

342

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP04380
(show subtarget assignments)

1

cloned

No

STM3713_1_404

16766998

rfaL

O-antigen ligase [Salmonella typhimurium...

404

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05059
(show subtarget assignments)

1

soluble

No

CD0690

126698269

putative nucleotide phosphodiesterase [C...

655

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GVE

15.3%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP05057
(show subtarget assignments)

1

cloned

No

CD0266

126697838

fliA

RNA polymerase sigma factor for flagella...

233

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

38.2%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04395
(show subtarget assignments)

1

cloned

No

FTT0076

56707255

sucA

2-oxoglutarate dehydrogenase E1 componen...

941

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2JGD

47.8%

Francisella tularensis

IDP05315
(show subtarget assignments)

1

cloned

No

BAS0383

49183411

-

cell wall anchor domain-containing prote...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

23.6%

Bacillus anthracis

Cell envelope: Other

IDP05145
(show subtarget assignments)

1

soluble

No

BAS4679

49187670

-

hypothetical protein BAS4679 [Bacillus a...

357

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05317
(show subtarget assignments)

1

cloned

No

lmo0638

16802680

-

hypothetical protein lmo0638 [Listeria m...

209

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05318
(show subtarget assignments)

1

soluble

No

lmo0697

16802739

-

flagellar hook protein FlgE [Listeria mo...

411

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A69

30.6%

Listeria monocytogenes

Cellular processes: Chemotaxis and motility

IDP04383
(show subtarget assignments)

1

purified

No

BAS4455

49187450

phenylalanyl-tRNA synthetase subunit bet...

806

Proposed to be essential proteins

Phase 4: April 2009

2RHS

49.8%

Bacillus anthracis

IDP05143
(show subtarget assignments)

1

cloned

No

BAS4423

49187418

-

triple helix repeat-containing collagen ...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WCK

27.6%

Bacillus anthracis

Unknown function: General

IDP05081
(show subtarget assignments)

1

expressed

No

lmo2027

16804066

-

putative cell surface protein, internali...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y5Q

23.2%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05324
(show subtarget assignments)

1

cloned

No

CD3431

126701054

putative cobalamin biosynthesis kinase [...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VIS

24.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05167
(show subtarget assignments)

1

purified

No

lmo1333

16803373

-

hypothetical protein lmo1333 [Listeria m...

153

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP05065
(show subtarget assignments)

1

soluble

No

CD2469

126700086

spoIIP

putative stage II sporulation protein P ...

339

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cellular processes: Sporulation and germination

IDP05082
(show subtarget assignments)

1

cloned

No

lmo2179

16804218

-

peptidoglycan binding protein [Listeria ...

1152

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KT7

2.3%

Listeria monocytogenes

Regulatory functions: Other

IDP05322
(show subtarget assignments)

1

cloned

No

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05016
(show subtarget assignments)

1

soluble

No

BA_2056

30256706

putative lipoprotein [Bacillus anthracis...

59

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04396
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4797

49187787

pyridine nucleotide-disulphide oxidoredu...

331

Proposed to be essential proteins

Phase 4: April 2009

3LZW

76.7%

Bacillus anthracis

IDP90992
(show subtarget assignments)

8

cloned

No

y1333

22125232

DNA-binding transcriptional regulator Is...

185

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

3T8R

25.4%

Yersinia pestis

IDP90991
(show subtarget assignments)

8

cloned

No

y1282

22125182

formate acetyltransferase [Yersinia pest...

150

other biological interest / stress-response protein replacind PflA in PflA/PflB complex

Community Requests

1CM5

40%

Yersinia pestis