Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00427 (show subtarget assignments)	1	in_pdb 3FWW	No	YPO4119	16124227	glmU	bifunctional N-acetylglucosamine-1-phosp...	456	Drug Target Function	Phase 2: March 2008	3FWW	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90665 (show subtarget assignments)	8	in_crystallization_trials	No	VC2618	15642613	argD	bifunctional N-succinyldiaminopimelate-a...	403	Predicted Essential	Community Requests	2PB0	58.1%	Vibrio cholerae

IDP02721 (show subtarget assignments)	1	soluble	No	GBAA4007	47529300	coaBC	bifunctional phosphopantothenoylcysteine...	401	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90659 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0822	15792160	dfp	bifunctional phosphopantothenoylcysteine...	384	Predicted Essential	Community Requests	1E20	17.2%	Campylobacter jejuni

IDP90780 (show subtarget assignments)	8	soluble	No	VC0215	15640245		bifunctional phosphopantothenoylcysteine...	399	Predicted Essential	Community Requests	1U7U	32.8%	Vibrio cholerae

IDP90570 (show subtarget assignments)	8	in_pdb 4EHI	No	Cj0953c	15792282	purH	bifunctional phosphoribosylaminoimidazol...	510	Predicted Essential	Community Requests	3ZZM	39.2%	Campylobacter jejuni

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02302 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0203c	56707367	purH	bifunctional phosphoribosylaminoimidazol...	515	Drug Target	Phase 3: June 2008	3ZZM	47.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05540 (show subtarget assignments)	1	cloned	No	CD3515	126701139	glmU	bifunctional protein [Clostridium diffic...	459	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	4AAW	48.4%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP01179 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01118 (show subtarget assignments)	1	crystallized	No	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01186 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0298	81584380		Bifunctional purine biosynthesis protein...	511	Conserved Gene / Pathway	Phase 2: March 2008	3ZZM	44.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00091 (show subtarget assignments)	0	work_stopped	No	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90654 (show subtarget assignments)	8	expressed	No	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP91640 (show subtarget assignments)	8	cloned	No	NP_216900	15609521		bifunctional salicyl-AMP ligase/salicyl-...	565	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1MD9	42.1%	Mycobacterium tuberculosis

IDP91214 (show subtarget assignments)	8	expressed	No	Blon_1597	189439474	aroB	bifunctional shikimate kinase/3-dehydroq...	540	potential drug target / Shikimate pathway enzyme	Community Requests	3QBD	32.6%	Bifidobacterium longum

IDP00959 (show subtarget assignments)	1	soluble	No	STM1303	16764654	argD	bifunctional succinylornithine transamin...	408	Conserved Gene / Pathway	Phase 2: March 2008	2PB0	60.8%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP91002 (show subtarget assignments)	8	selected	No	y1919	22125812		bifunctional UDP-glucuronic acid decarbo...	667	virulence/pathogenesis / -	Community Requests	1Z7E	70.2%	Yersinia pestis

IDP90108 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_013	68449087		bifunctional zinc finger-like protein/E3...	242	similar to VARV BEN68-zinc finger-like protein	Community Requests	2ECW	8.3%	Monkeypox virus

IDP04178 (show subtarget assignments)	1	expressed	No	VC2718	15642712		bioH protein [Vibrio cholerae O1 biovar ...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1M33	49.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP91318 (show subtarget assignments)	8	cloned	No	VV2_0362	27366803		biopolymer transport protein [Vibrio vul...	185	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP90722 (show subtarget assignments)	8	in_pdb 3OUZ 3OUU	No	Cj1290c	15792613	accC	biotin carboxylase [Campylobacter jejuni...	443	Predicted Essential	Community Requests	3OUU	100%	Campylobacter jejuni

IDP90641 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0099	15791487	birA	biotin--protein ligase [Campylobacter je...	217	Predicted Essential	Community Requests	2EAY	27.2%	Campylobacter jejuni

IDP90597 (show subtarget assignments)	8	soluble	No	VC0319	15640346		biotin--protein ligase [Vibrio cholerae ...	320	Predicted Essential	Community Requests	1BIA	54.7%	Vibrio cholerae

IDP90933 (show subtarget assignments)	8	expressed	No	YPO3759	16123896	birA	biotin--protein ligase [Yersinia pestis ...	319	Predicted Essential	Community Requests	1BIA	75.2%	Yersinia pestis

IDP04033 (show subtarget assignments)	1	soluble	No	VC1950	15641952		biotin sulfoxide reductase [Vibrio chole...	815	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1E18	48.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02046 (show subtarget assignments)	1	soluble	No	CBU_1007	29541589	bioB	biotin synthase [Coxiella burnetii RSA 4...	321	Conserved; Drug target functions	Phase 3: June 2008	1R30	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01958 (show subtarget assignments)	1	expressed	No	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04719 (show subtarget assignments)	1	expressed	No	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP91266 (show subtarget assignments)	8	cloned	No	NT05BA1576	49178391		birA bifunctional protein [Bacillus anth...	326	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RIR	34.6%	Bacillus anthracis	Regulatory functions: Other

IDP02176 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP00055 (show subtarget assignments)	0	work_stopped	No	BA_3696	30258217		blasticidin S deaminase, putative	142	Virulence	Phase 1: October 2007	3B8F	99.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91999 (show subtarget assignments)	8	selected	No	SpneCM_010100004482	298254857		BlpC ABC transporter [Streptococcus pneu...	453	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP02741 (show subtarget assignments)	1	purified	No	GBAA1900	47527194		BNR repeat-containing protein [Bacillus ...	323	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP01322 (show subtarget assignments)	1	purified	No	VC2296	15642294		bolA protein	106	Conserved Gene / Pathway	Phase 2: March 2008	2DHM	50.9%	Vibrio cholerae	Cellular processes	Other

IDP90298 (show subtarget assignments)	8	selected	No	TGME49_120190	211967550		bradyzoite-specific surface protein, put...	398	TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...	Community Requests	2JKS	37.7%	Toxoplasma gondii

IDP02770 (show subtarget assignments)	1	cloned	No	GBAA2774	47528065	acoC	branched-chain alpha-keto acid dehydroge...	398	Essential; Drug target functions	Phase 3: June 2008	3DUF	33.2%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02829 (show subtarget assignments)	1	cloned	No	GBAA4382	47529677	bfmbB	branched-chain alpha-keto acid dehydroge...	439	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.4%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP91963 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100009553	298255821		branched-chain amino acid ABC transporte...	386	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3TD9	26.7%	Streptococcus pneumoniae

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP90704 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0269c	15791640	ilvE	branched-chain amino acid aminotransfera...	304	Predicted Essential	Community Requests	3U0G	55.6%	Campylobacter jejuni

IDP00475 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3808	16123942	livK	branched-chain amino acid-binding protei...	371	Virulence Associated Factor	Phase 2: March 2008	1USG	71.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00046 (show subtarget assignments)	1	in_pdb 3FOB	Yes	BA_3165	30257736		bromoperoxidase	278	Virulence	Phase 1: October 2007	3FOB	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91521 (show subtarget assignments)	8	selected	No	TGME49_040910	237834825		C2 domain-containing protein [Toxoplasma...	1990	potential drug target; virulence/pathogenesis / DOC2.1 was identified in a temperature sensitive host cell invasion/egress mutan...	Community Requests			Toxoplasma gondii

IDP91689 (show subtarget assignments)	8	selected	No	NP_000706	4502503	C4BPA	C4b-binding protein alpha chain precurso...	597	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2GSX	28.8%	Homo sapiens

IDP04180 (show subtarget assignments)	1	expressed	No	VCA0141	15600911		C4-dicarboxylate transport sensor protei...	684	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	9.9%	Vibrio cholerae	Regulatory functions	Other

IDP91662 (show subtarget assignments)	8	selected	No	NP_004351	4757960	CDH1	cadherin-1 preproprotein [Homo sapiens]	882	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1Q55	57.5%	Homo sapiens

IDP05159 (show subtarget assignments)	1	cloned	No	BA_1290	30255237	calY	camelysin [Bacillus anthracis str. Ames]...	197	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP91407 (show subtarget assignments)	8	purified	No	VV1_0729	27364183		cAMP-binding proteins - catabolite gene ...	187	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DN7	23.4%	Vibrio vulnificus

IDP91543 (show subtarget assignments)	8	selected	No	TGME49_057080	237831315		cAMP-specific 3',5'-cyclic phosphodieste...	1691	potential drug target / Phosphodiesterases are key regulators of cell signalling pathways and are attrac...	Community Requests	3ECM	6.6%	Toxoplasma gondii

IDP00267 (show subtarget assignments)	1	cloned	No	AAX48017_4-113	61652905	N/A	Capsid protein (C)	111	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.4%	Dengue virus	Unclassified	N/A

IDP00263 (show subtarget assignments)	1	cloned	No	AF180817_1-114	7329982	N/A	Capsid protein (C)	114	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.5%	Dengue virus	Unclassified	N/A

IDP00277 (show subtarget assignments)	1	cloned	No	AAA99437_5-114	323469	N/A	Capsid protein (C)	110	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	57.3%	Dengue virus	Unclassified	N/A

IDP01770 (show subtarget assignments)	1	expressed	No	Cj1447c	15792764	kpsT	capsular polysaccharide ABC transporter,...	220	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2BBS	26.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01977 (show subtarget assignments)	1	cloned	No	Cj1444c	15792762	kpsD	capsular polysaccharide ABC transporter,...	552	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP00639 (show subtarget assignments)	1	cloned	No	SACOL0114	57286663		capsular polysaccharide biosynthesis gly...	230	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00835 (show subtarget assignments)	1	purified	No	SACOL2685	57286588	cap1C	capsular polysaccharide biosynthesis pro...	255	Conserved Gene / Pathway	Phase 2: March 2008	3QY6	41.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00758 (show subtarget assignments)	1	soluble	No	SACOL0140	57285343	cap5E	capsular polysaccharide biosynthesis pro...	342	Conserved Gene / Pathway	Phase 2: March 2008	2GN4	38%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00651 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0143	57285346	cap5H	capsular polysaccharide biosynthesis pro...	208	Conserved Gene / Pathway	Phase 2: March 2008	3EEV	33.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00701 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0149	57285352	cap5N	capsular polysaccharide biosynthesis pro...	295	Conserved Gene / Pathway	Phase 2: March 2008	1Z45	22.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00702 (show subtarget assignments)	0	work_stopped	No	SACOL0150	57285353	cap5O	capsular polysaccharide biosynthesis pro...	420	Drug Target Function	Phase 2: March 2008	3OJL	98.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05213 (show subtarget assignments)	1	soluble	No	CD2769	126700385		capsular polysaccharide biosynthesis pro...	597	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2GN4	17.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91986 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006694	298255280		capsule biosynthesis integral membrane r...	481	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2XXP	74.6%	Streptococcus pneumoniae

IDP01167 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP01168 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0084	47566748		capsule synthesis trans-acting positive ...	483	Virulence Associated Factor	Phase 2: March 2008	3SQN	8.5%	Bacillus anthracis

IDP02673 (show subtarget assignments)	1	expressed	No	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP91960 (show subtarget assignments)	8	selected	No	SpneCM_010100008232	298255567		carbamate kinase [Streptococcus pneumoni...	423	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B7B	24.1%	Streptococcus pneumoniae

IDP00671 (show subtarget assignments)	1	purified	No	SACOL1215	57285958	carB	carbamoyl phosphate synthase large subun...	1057	Drug Target Function	Phase 2: March 2008	1BXR	49.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04425 (show subtarget assignments)	1	cloned	No	GBAA4025	47529318	carB	carbamoyl phosphate synthase large subun...	1072	conserved gene; putative drug target function;	Phase 4: April 2009	1BXR	49.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90807 (show subtarget assignments)	8	cloned	No	Cj0279	15791649	carB	carbamoyl phosphate synthase large subun...	1089	Predicted Essential	Community Requests	1BXR	55.3%	Campylobacter jejuni

IDP90592 (show subtarget assignments)	8	in_crystallization_trials	No	VC2389	15642386	carB	carbamoyl phosphate synthase large subun...	1076	Predicted Essential	Community Requests	1BXR	85.6%	Vibrio cholerae

IDP00528 (show subtarget assignments)	1	expressed	No	YPO0481	16120811	carA	carbamoyl phosphate synthase small subun...	391	Drug Target Function	Phase 2: March 2008	1BXR	84.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02722 (show subtarget assignments)	1	cloned	No	GBAA4026	47529319	carA	carbamoyl phosphate synthase small subun...	365	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1BXR	46.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90859 (show subtarget assignments)	8	expressed	No	Cj1494c	15792809	carA	carbamoyl phosphate synthase small subun...	372	Predicted Essential	Community Requests	1BXR	40.3%	Campylobacter jejuni

IDP02512 (show subtarget assignments)	1	soluble	No	FTT1663	56708674	carA	carbamoyl phosphate synthase small subun...	388	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1BXR	48.5%	Francisella tularensis	N/A	N/A

IDP90910 (show subtarget assignments)	8	soluble	No	VC2390	15642387		carbamoyl phosphate synthase small subun...	379	Predicted Essential	Community Requests	1CS0	82.3%	Vibrio cholerae

IDP90274 (show subtarget assignments)	8	selected	No	TGME49_015260	211968509		carbamoyl phosphate synthetase II [Toxop...	1699	Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...	Community Requests	1A9X	27.1%	Toxoplasma gondii

IDP91087 (show subtarget assignments)	8	expressed	No	BMA_3102	52427493		carbohydrate isomerase, KpsF/GutQ family...	327	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	30.9%	Burkholderia mallei	Energy metabolism: Sugars

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP00909 (show subtarget assignments)	0	work_stopped	No	STM0171	16763561	yadF	carbonic anhydrase	220	Conserved Gene / Pathway	Phase 2: March 2008	3QY1	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP02798 (show subtarget assignments)	1	purified	No	GBAA5049	47530348		carbonic anhydrase [Bacillus anthracis s...	187	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1G5C	34.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP05494 (show subtarget assignments)	1	soluble	No	CD0234	126697805	csrA	carbon storage regulator [Clostridium di...	70	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1T3O	47.1%	Clostridium difficile	Regulatory functions: RNA interactions

IDP01233 (show subtarget assignments)	1	purified	No	BA_5335	30259811	estA	carboxylesterase	246	Drug Target Function	Phase 2: March 2008	1R1D	79.3%	Bacillus anthracis	Cellular processes	Detoxification

IDP00781 (show subtarget assignments)	1	expressed	No	SACOL0845	57284307	est	carboxylesterase	246	Conserved Gene / Pathway	Phase 2: March 2008	1R1D	57.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP01059 (show subtarget assignments)	1	purified	No	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01809 (show subtarget assignments)	1	purified	No	FTT0258	56707414		carboxylesterase/phospholipase family pr...	222	Drug Target	Phase 3: June 2008	1FJ2	39.6%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP00675 (show subtarget assignments)	1	cloned	No	SACOL1455	57284564		carboxyl-terminal protease	496	Drug Target Function	Phase 2: March 2008	1FC6	20%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01804 (show subtarget assignments)	1	cloned	No	GBAA5414	47530727		carboxyl-terminal protease [Bacillus ant...	469	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FC6	19.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02080 (show subtarget assignments)	1	in_pdb 3KZ2 3IH1	No	GBAA2350	47527645	yqiQ	carboxyvinyl-carboxyphosphonate phosphor...	302	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IH1	100%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01678 (show subtarget assignments)	1	cloned	No	GBAA5591	47530913		cardiolipin synthetase domain-containing...	397	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP90586 (show subtarget assignments)	8	cloned	No	YPO2188	16122418	cls	cardiolipin synthetase [Yersinia pestis ...	486	Predicted Essential	Community Requests			Yersinia pestis

IDP00798 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1368	57284523	kataA	catalase	473	Conserved Gene / Pathway	Phase 2: March 2008	2ISA	63.4%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00420 (show subtarget assignments)	1	purified	No	YPO1207	16121498	katA	catalase	480	Virulence Associated Factor	Phase 2: March 2008	1M85	84.2%	Yersinia pestis	Cellular processes	Detoxification

IDP00427
(show subtarget assignments)

1

in_pdb
3FWW

No

YPO4119

16124227

glmU

bifunctional N-acetylglucosamine-1-phosp...

456

Drug Target Function

Phase 2: March 2008

3FWW

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90665
(show subtarget assignments)

8

in_crystallization_trials

No

VC2618

15642613

argD

bifunctional N-succinyldiaminopimelate-a...

403

Predicted Essential

Community Requests

2PB0

58.1%

Vibrio cholerae

IDP02721
(show subtarget assignments)

1

soluble

No

GBAA4007

47529300

coaBC

bifunctional phosphopantothenoylcysteine...

401

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90659
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0822

15792160

dfp

bifunctional phosphopantothenoylcysteine...

384

Predicted Essential

Community Requests

1E20

17.2%

Campylobacter jejuni

IDP90780
(show subtarget assignments)

8

soluble

No

VC0215

15640245

bifunctional phosphopantothenoylcysteine...

399

Predicted Essential

Community Requests

1U7U

32.8%

Vibrio cholerae

IDP90570
(show subtarget assignments)

8

in_pdb
4EHI

No

Cj0953c

15792282

purH

bifunctional phosphoribosylaminoimidazol...

510

Predicted Essential

Community Requests

3ZZM

39.2%

Campylobacter jejuni

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02302
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0203c

56707367

purH

bifunctional phosphoribosylaminoimidazol...

515

Drug Target

Phase 3: June 2008

3ZZM

47.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05540
(show subtarget assignments)

1

cloned

No

CD3515

126701139

glmU

bifunctional protein [Clostridium diffic...

459

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

4AAW

48.4%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP01179
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01118
(show subtarget assignments)

1

crystallized

No

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01186
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0298

81584380

Bifunctional purine biosynthesis protein...

511

Conserved Gene / Pathway

Phase 2: March 2008

3ZZM

44.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00091
(show subtarget assignments)

0

work_stopped

No

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90654
(show subtarget assignments)

8

expressed

No

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP91640
(show subtarget assignments)

8

cloned

No

NP_216900

15609521

bifunctional salicyl-AMP ligase/salicyl-...

565

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1MD9

42.1%

Mycobacterium tuberculosis

IDP91214
(show subtarget assignments)

8

expressed

No

Blon_1597

189439474

aroB

bifunctional shikimate kinase/3-dehydroq...

540

potential drug target / Shikimate pathway enzyme

Community Requests

3QBD

32.6%

Bifidobacterium longum

IDP00959
(show subtarget assignments)

1

soluble

No

STM1303

16764654

argD

bifunctional succinylornithine transamin...

408

Conserved Gene / Pathway

Phase 2: March 2008

2PB0

60.8%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP91002
(show subtarget assignments)

8

selected

No

y1919

22125812

bifunctional UDP-glucuronic acid decarbo...

667

virulence/pathogenesis / -

Community Requests

1Z7E

70.2%

Yersinia pestis

IDP90108
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_013

68449087

bifunctional zinc finger-like protein/E3...

242

similar to VARV BEN68-zinc finger-like protein

Community Requests

2ECW

8.3%

Monkeypox virus

IDP04178
(show subtarget assignments)

1

expressed

No

VC2718

15642712

bioH protein [Vibrio cholerae O1 biovar ...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1M33

49.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP91318
(show subtarget assignments)

8

cloned

No

VV2_0362

27366803

biopolymer transport protein [Vibrio vul...

185

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP90722
(show subtarget assignments)

8

in_pdb
3OUZ
3OUU

No

Cj1290c

15792613

accC

biotin carboxylase [Campylobacter jejuni...

443

Predicted Essential

Community Requests

3OUU

100%

Campylobacter jejuni

IDP90641
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0099

15791487

birA

biotin--protein ligase [Campylobacter je...

217

Predicted Essential

Community Requests

2EAY

27.2%

Campylobacter jejuni

IDP90597
(show subtarget assignments)

8

soluble

No

VC0319

15640346

biotin--protein ligase [Vibrio cholerae ...

320

Predicted Essential

Community Requests

1BIA

54.7%

Vibrio cholerae

IDP90933
(show subtarget assignments)

8

expressed

No

YPO3759

16123896

birA

biotin--protein ligase [Yersinia pestis ...

319

Predicted Essential

Community Requests

1BIA

75.2%

Yersinia pestis

IDP04033
(show subtarget assignments)

1

soluble

No

VC1950

15641952

biotin sulfoxide reductase [Vibrio chole...

815

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1E18

48.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02046
(show subtarget assignments)

1

soluble

No

CBU_1007

29541589

bioB

biotin synthase [Coxiella burnetii RSA 4...

321

Conserved; Drug target functions

Phase 3: June 2008

1R30

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01958
(show subtarget assignments)

1

expressed

No

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04719
(show subtarget assignments)

1

expressed

No

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP91266
(show subtarget assignments)

8

cloned

No

NT05BA1576

49178391

birA bifunctional protein [Bacillus anth...

326

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RIR

34.6%

Bacillus anthracis

Regulatory functions: Other

IDP02176
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP00055
(show subtarget assignments)

0

work_stopped

No

BA_3696

30258217

blasticidin S deaminase, putative

142

Virulence

Phase 1: October 2007

3B8F

99.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91999
(show subtarget assignments)

8

selected

No

SpneCM_010100004482

298254857

BlpC ABC transporter [Streptococcus pneu...

453

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP02741
(show subtarget assignments)

1

purified

No

GBAA1900

47527194

BNR repeat-containing protein [Bacillus ...

323

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP01322
(show subtarget assignments)

1

purified

No

VC2296

15642294

bolA protein

106

Conserved Gene / Pathway

Phase 2: March 2008

2DHM

50.9%

Vibrio cholerae

Cellular processes

Other

IDP90298
(show subtarget assignments)

8

selected

No

TGME49_120190

211967550

bradyzoite-specific surface protein, put...

398

TgSRS9 is one of the few in the SAG1 family that is expressed only in bradyzoite...

Community Requests

2JKS

37.7%

Toxoplasma gondii

IDP02770
(show subtarget assignments)

1

cloned

No

GBAA2774

47528065

acoC

branched-chain alpha-keto acid dehydroge...

398

Essential; Drug target functions

Phase 3: June 2008

3DUF

33.2%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02829
(show subtarget assignments)

1

cloned

No

GBAA4382

47529677

bfmbB

branched-chain alpha-keto acid dehydroge...

439

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.4%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP91963
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100009553

298255821

branched-chain amino acid ABC transporte...

386

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3TD9

26.7%

Streptococcus pneumoniae

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP90704
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0269c

15791640

ilvE

branched-chain amino acid aminotransfera...

304

Predicted Essential

Community Requests

3U0G

55.6%

Campylobacter jejuni

IDP00475
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3808

16123942

livK

branched-chain amino acid-binding protei...

371

Virulence Associated Factor

Phase 2: March 2008

1USG

71.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00046
(show subtarget assignments)

1

in_pdb
3FOB

Yes

BA_3165

30257736

bromoperoxidase

278

Virulence

Phase 1: October 2007

3FOB

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91521
(show subtarget assignments)

8

selected

No

TGME49_040910

237834825

C2 domain-containing protein [Toxoplasma...

1990

potential drug target; virulence/pathogenesis / DOC2.1 was identified in a temperature sensitive host cell invasion/egress mutan...

Community Requests

Toxoplasma gondii

IDP91689
(show subtarget assignments)

8

selected

No

NP_000706

4502503

C4BPA

C4b-binding protein alpha chain precurso...

597

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2GSX

28.8%

Homo sapiens

IDP04180
(show subtarget assignments)

1

expressed

No

VCA0141

15600911

C4-dicarboxylate transport sensor protei...

684

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

9.9%

Vibrio cholerae

Regulatory functions

Other

IDP91662
(show subtarget assignments)

8

selected

No

NP_004351

4757960

CDH1

cadherin-1 preproprotein [Homo sapiens]

882

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1Q55

57.5%

Homo sapiens

IDP05159
(show subtarget assignments)

1

cloned

No

BA_1290

30255237

calY

camelysin [Bacillus anthracis str. Ames]...

197

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP91407
(show subtarget assignments)

8

purified

No

VV1_0729

27364183

cAMP-binding proteins - catabolite gene ...

187

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DN7

23.4%

Vibrio vulnificus

IDP91543
(show subtarget assignments)

8

selected

No

TGME49_057080

237831315

cAMP-specific 3',5'-cyclic phosphodieste...

1691

potential drug target / Phosphodiesterases are key regulators of cell signalling pathways and are attrac...

Community Requests

3ECM

6.6%

Toxoplasma gondii

IDP00267
(show subtarget assignments)

1

cloned

No

AAX48017_4-113

61652905

N/A

Capsid protein (C)

111

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.4%

Dengue virus

Unclassified

N/A

IDP00263
(show subtarget assignments)

1

cloned

No

AF180817_1-114

7329982

N/A

Capsid protein (C)

114

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.5%

Dengue virus

Unclassified

N/A

IDP00277
(show subtarget assignments)

1

cloned

No

AAA99437_5-114

323469

N/A

Capsid protein (C)

110

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

57.3%

Dengue virus

Unclassified

N/A

IDP01770
(show subtarget assignments)

1

expressed

No

Cj1447c

15792764

kpsT

capsular polysaccharide ABC transporter,...

220

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2BBS

26.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01977
(show subtarget assignments)

1

cloned

No

Cj1444c

15792762

kpsD

capsular polysaccharide ABC transporter,...

552

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP00639
(show subtarget assignments)

1

cloned

No

SACOL0114

57286663

capsular polysaccharide biosynthesis gly...

230

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00835
(show subtarget assignments)

1

purified

No

SACOL2685

57286588

cap1C

capsular polysaccharide biosynthesis pro...

255

Conserved Gene / Pathway

Phase 2: March 2008

3QY6

41.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00758
(show subtarget assignments)

1

soluble

No

SACOL0140

57285343

cap5E

capsular polysaccharide biosynthesis pro...

342

Conserved Gene / Pathway

Phase 2: March 2008

2GN4

38%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00651
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0143

57285346

cap5H

capsular polysaccharide biosynthesis pro...

208

Conserved Gene / Pathway

Phase 2: March 2008

3EEV

33.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00701
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0149

57285352

cap5N

capsular polysaccharide biosynthesis pro...

295

Conserved Gene / Pathway

Phase 2: March 2008

1Z45

22.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00702
(show subtarget assignments)

0

work_stopped

No

SACOL0150

57285353

cap5O

capsular polysaccharide biosynthesis pro...

420

Drug Target Function

Phase 2: March 2008

3OJL

98.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05213
(show subtarget assignments)

1

soluble

No

CD2769

126700385

capsular polysaccharide biosynthesis pro...

597

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2GN4

17.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91986
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006694

298255280

capsule biosynthesis integral membrane r...

481

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2XXP

74.6%

Streptococcus pneumoniae

IDP01167
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP01168
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0084

47566748

capsule synthesis trans-acting positive ...

483

Virulence Associated Factor

Phase 2: March 2008

3SQN

8.5%

Bacillus anthracis

IDP02673
(show subtarget assignments)

1

expressed

No

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP91960
(show subtarget assignments)

8

selected

No

SpneCM_010100008232

298255567

carbamate kinase [Streptococcus pneumoni...

423

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B7B

24.1%

Streptococcus pneumoniae

IDP00671
(show subtarget assignments)

1

purified

No

SACOL1215

57285958

carB

carbamoyl phosphate synthase large subun...

1057

Drug Target Function

Phase 2: March 2008

1BXR

49.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04425
(show subtarget assignments)

1

cloned

No

GBAA4025

47529318

carB

carbamoyl phosphate synthase large subun...

1072

conserved gene; putative drug target function;

Phase 4: April 2009

1BXR

49.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90807
(show subtarget assignments)

8

cloned

No

Cj0279

15791649

carB

carbamoyl phosphate synthase large subun...

1089

Predicted Essential

Community Requests

1BXR

55.3%

Campylobacter jejuni

IDP90592
(show subtarget assignments)

8

in_crystallization_trials

No

VC2389

15642386

carB

carbamoyl phosphate synthase large subun...

1076

Predicted Essential

Community Requests

1BXR

85.6%

Vibrio cholerae

IDP00528
(show subtarget assignments)

1

expressed

No

YPO0481

16120811

carA

carbamoyl phosphate synthase small subun...

391

Drug Target Function

Phase 2: March 2008

1BXR

84.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02722
(show subtarget assignments)

1

cloned

No

GBAA4026

47529319

carA

carbamoyl phosphate synthase small subun...

365

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1BXR

46.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90859
(show subtarget assignments)

8

expressed

No

Cj1494c

15792809

carA

carbamoyl phosphate synthase small subun...

372

Predicted Essential

Community Requests

1BXR

40.3%

Campylobacter jejuni

IDP02512
(show subtarget assignments)

1

soluble

No

FTT1663

56708674

carA

carbamoyl phosphate synthase small subun...

388

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1BXR

48.5%

Francisella tularensis

N/A

IDP90910
(show subtarget assignments)

8

soluble

No

VC2390

15642387

carbamoyl phosphate synthase small subun...

379

Predicted Essential

Community Requests

1CS0

82.3%

Vibrio cholerae

IDP90274
(show subtarget assignments)

8

selected

No

TGME49_015260

211968509

carbamoyl phosphate synthetase II [Toxop...

1699

Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...

Community Requests

1A9X

27.1%

Toxoplasma gondii

IDP91087
(show subtarget assignments)

8

expressed

No

BMA_3102

52427493

carbohydrate isomerase, KpsF/GutQ family...

327

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

30.9%

Burkholderia mallei

Energy metabolism: Sugars

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP00909
(show subtarget assignments)

0

work_stopped

No

STM0171

16763561

yadF

carbonic anhydrase

220

Conserved Gene / Pathway

Phase 2: March 2008

3QY1

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP02798
(show subtarget assignments)

1

purified

No

GBAA5049

47530348

carbonic anhydrase [Bacillus anthracis s...

187

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1G5C

34.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP05494
(show subtarget assignments)

1

soluble

No

CD0234

126697805

csrA

carbon storage regulator [Clostridium di...

70

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1T3O

47.1%

Clostridium difficile

Regulatory functions: RNA interactions

IDP01233
(show subtarget assignments)

1

purified

No

BA_5335

30259811

estA

carboxylesterase

246

Drug Target Function

Phase 2: March 2008

1R1D

79.3%

Bacillus anthracis

Cellular processes

Detoxification

IDP00781
(show subtarget assignments)

1

expressed

No

SACOL0845

57284307

est

carboxylesterase

246

Conserved Gene / Pathway

Phase 2: March 2008

1R1D

57.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP01059
(show subtarget assignments)

1

purified

No

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01809
(show subtarget assignments)

1

purified

No

FTT0258

56707414

carboxylesterase/phospholipase family pr...

222

Drug Target

Phase 3: June 2008

1FJ2

39.6%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP00675
(show subtarget assignments)

1

cloned

No

SACOL1455

57284564

carboxyl-terminal protease

496

Drug Target Function

Phase 2: March 2008

1FC6

20%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01804
(show subtarget assignments)

1

cloned

No

GBAA5414

47530727

carboxyl-terminal protease [Bacillus ant...

469

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FC6

19.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02080
(show subtarget assignments)

1

in_pdb
3KZ2
3IH1

No

GBAA2350

47527645

yqiQ

carboxyvinyl-carboxyphosphonate phosphor...

302

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IH1

100%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01678
(show subtarget assignments)

1

cloned

No

GBAA5591

47530913

cardiolipin synthetase domain-containing...

397

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP90586
(show subtarget assignments)

8

cloned

No

YPO2188

16122418

cls

cardiolipin synthetase [Yersinia pestis ...

486

Predicted Essential

Community Requests

Yersinia pestis

IDP00798
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1368

57284523

kataA

catalase

473

Conserved Gene / Pathway

Phase 2: March 2008

2ISA

63.4%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00420
(show subtarget assignments)

1

purified

No

YPO1207

16121498

katA

catalase

480

Virulence Associated Factor

Phase 2: March 2008

1M85

84.2%

Yersinia pestis

Cellular processes

Detoxification