Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04690 (show subtarget assignments)	1	expressed	No	GBAA5029	47530328		sensor histidine kinase [Bacillus anthra...	418	putative drug target function;	Phase 4: April 2009	3D36	17.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04675 (show subtarget assignments)	1	soluble	No	GBAA2291	47527591		sensor histidine kinase [Bacillus anthra...	377	putative drug target function;	Phase 4: April 2009	3A0R	26.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04397 (show subtarget assignments)	1	expressed	No	GBAA3230	47528520		sensor histidine kinase [Bacillus anthra...	457	putative drug target function;	Phase 4: April 2009	2C2A	17.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01736 (show subtarget assignments)	1	expressed	No	GBAA5503	47530821		sensor histidine kinase [Bacillus anthra...	476	Conserved; Drug target functions	Phase 3: June 2008	2C2A	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02338 (show subtarget assignments)	1	cloned	No	GBAA1456	47526731		sensor histidine kinase [Bacillus anthra...	351	Conserved; Drug target functions	Phase 3: June 2008	3EHH	14.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04430 (show subtarget assignments)	1	purified	No	GBAA4921	47530215		sensor histidine kinase [Bacillus anthra...	484	putative drug target function;	Phase 4: April 2009	2C2A	16.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP90001 (show subtarget assignments)	8	cloned	No	FTT0094c	56603762	qseC	sensor histidine kinase	475	Drug Target (Community Request)	Community Requests	3A0R	15.8%	Francisella tularensis

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP02681 (show subtarget assignments)	1	soluble	No	STM3682	16766967	selB	selenocysteinyl-tRNA-specific translatio...	616	Conserved; Drug target functions	Phase 3: June 2008	1D8T	19%	Salmonella enterica	Protein synthesis	Translation factors

IDP02062 (show subtarget assignments)	1	soluble	No	CBU_1357	29541922	csdB	selenocysteine lyase [Coxiella burnetii ...	405	Conserved; Drug target functions	Phase 3: June 2008	1I29	50.9%	Coxiella burnetii	Central intermediary metabolism	Other

IDP91926 (show subtarget assignments)	8	selected	No	SpneCM_010100003840	298254733	scpB	segregation and condensation protein B [...	189	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2Z99	29.6%	Streptococcus pneumoniae

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP00631 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1537	57284636	scpB	segregation and condensation protein B	180	Conserved Gene / Pathway	Phase 2: March 2008	1T6S	23.9%	Staphylococcus aureus	Cellular processes	Cell division

IDP90286 (show subtarget assignments)	8	in_pdb 3UKS	No	TGME49_035700	211966629		sedoheptulose-1,7 bisphosphatase, putati...	330	Unpublished data indicate that the Calvin cycle enzyme sedoheptulose-1,7-bisphos...	Community Requests	3UKS	100%	Toxoplasma gondii

IDP04440 (show subtarget assignments)	1	cloned	No	YPO0266	115346083		secretion system apparatus protein [Yers...	682	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2X49	15.4%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90324 (show subtarget assignments)	8	expressed	No	CT088	15604807	sycE	secretion chaperone [Chlamydia trachomat...	146	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91363 (show subtarget assignments)	8	expressed	No	VV1_2834	27366116		secreted hydrolase [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ICH	28.6%	Vibrio vulnificus

IDP90106 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_011	68449085		secreted epidermal growth factor-like pr...	142	similar to VACV-COP-C11R, MPXV-ZAI96-D3R	Community Requests	1K36	16.2%	Monkeypox virus

IDP04697 (show subtarget assignments)	1	soluble	No	YPCD1.29c	16082717	yopB	secreted effector protein [Yersinia pest...	401	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01707 (show subtarget assignments)	1	crystallized	No	STM1631	16764975	sseJ	secreted effector protein [Salmonella ty...	408	VIRULENCE FACTOR	Phase 3: June 2008	3CXB	10%	Salmonella enterica	N/A	N/A

IDP01023 (show subtarget assignments)	1	in_crystallization_trials	No	STM1051	16764411	sseI	secreted effector protein [Phage Gifsy-2...	322	Virulence Associated Factor	Phase 2: March 2008	3CXB	15.8%	Salmonella enterica	Unknown function	General

IDP01014 (show subtarget assignments)	1	in_crystallization_trials	No	STM2780	16766091	pipB2	secreted effector protein	350	Virulence Associated Factor	Phase 2: March 2008	2LEZ	41.4%	Salmonella enterica	Unknown function	General

IDP05583 (show subtarget assignments)	1	soluble	No	BA_2249	30256893		SCO1/SenC family lipoprotein [Bacillus a...	195	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XZO	45.6%	Bacillus anthracis	Unknown function: General

IDP02514 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0116	29540736	mraW	S-adenosyl-methyltransferase MraW [Coxie...	307	Conserved; Drug target functions	Phase 3: June 2008	1WG8	46.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP05529 (show subtarget assignments)	1	cloned	No	CD2658	126700272	mraW	S-adenosyl-methyltransferase [Clostridiu...	318	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WG8	41.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04616 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4313	49187308		S-adenosylmethionine:tRNA ribosyltransfe...	350	Proposed to be essential proteins	Phase 4: April 2009	1YY3	71.4%	Bacillus anthracis

IDP90798 (show subtarget assignments)	8	in_crystallization_trials	No	VC0472	15640499		S-adenosylmethionine synthetase [Vibrio ...	385	Predicted Essential	Community Requests	1FUG	87.5%	Vibrio cholerae

IDP92043 (show subtarget assignments)	8	selected	No	TGME49_040690	237834781		S-adenosylmethionine synthetase, putativ...	415	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2P02	60.5%	Toxoplasma gondii

IDP90872 (show subtarget assignments)	8	expressed	No	Cj1096c	15792421	metK	S-adenosylmethionine synthetase [Campylo...	398	Predicted Essential	Community Requests	3IML	41.7%	Campylobacter jejuni

IDP01626 (show subtarget assignments)	1	cloned	No	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00748 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1837	57284761	metK	S-adenosylmethionine synthetase	397	Drug Target Function	Phase 2: March 2008	1FUG	62.2%	Staphylococcus aureus	Central intermediary metabolism	One-carbon metabolism

IDP90538 (show subtarget assignments)	8	soluble	No	YPO3412	16123561	speD	S-adenosylmethionine decarboxylase [Yers...	264	Predicted Essential	Community Requests			Yersinia pestis

IDP92073 (show subtarget assignments)	8	selected	No	TGME49_088860	237838049		ruvB-like 2 protein, putative [Toxoplasm...	508	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2XSZ	49.2%	Toxoplasma gondii

IDP92077 (show subtarget assignments)	8	selected	No	TGME49_097370	237843739		ruvB-like 1, putative [Toxoplasma gondii...	463	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	62.9%	Toxoplasma gondii

IDP92030 (show subtarget assignments)	8	selected	No	TGME49_019590	237842827		ruvB-like 1, putative [Toxoplasma gondii...	492	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	55.9%	Toxoplasma gondii

IDP90973 (show subtarget assignments)	8	selected	No	AND4_00045	163803697		RTX toxin RtxA [Vibrio sp. AND4]	525	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Vibrio sp.

IDP00167 (show subtarget assignments)	8	in_pdb 3FZY	Yes	VC1451	4455065	rtxA	RTX toxin RtxA	4545	Virulence	Community Requests	3EEB	4.6%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00166 (show subtarget assignments)	1	expressed	No	VC1450	15641461	rtxC	RTX toxin activating protein	153	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP02236 (show subtarget assignments)	1	cloned	No	FTT1108	56708186		rRNA methyltransferase [Francisella tula...	250	Drug Target	Phase 3: June 2008	1IPA	29.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP90535 (show subtarget assignments)	8	soluble	No	VC2695	15642690		rRNA methylase [Vibrio cholerae O1 biova...	158	Predicted Essential	Community Requests	3N4J	58.5%	Vibrio cholerae

IDP91589 (show subtarget assignments)	8	expressed	No	BAB41266	13699967	ermA	rRNA methylase [Staphylococcus aureus su...	243	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP91784 (show subtarget assignments)	8	soluble	No	SA1480	15927234	ermA	rRNA methylase Erm(A) [Staphylococcus au...	243	drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP02288 (show subtarget assignments)	1	cloned	No	FTT0932	56708030		ROK family protein [Francisella tularens...	283	Drug Target	Phase 3: June 2008	2YHY	29.2%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00802 (show subtarget assignments)	1	cloned	No	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04193 (show subtarget assignments)	1	cloned	No	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP05022 (show subtarget assignments)	1	cloned	No	CD1145	126698740	mreB2	rod shape-determining protein MreB [Clos...	353	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	54.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01231 (show subtarget assignments)	1	purified	No	BA_4684	30259179	mreB	rod shape-determining protein MreB	339	Drug Target Function	Phase 2: March 2008	1JCE	52.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05051 (show subtarget assignments)	1	cloned	No	CD0127	126697699	mreB1	rod shape-determining protein Mbl [Clost...	339	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	52.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02813 (show subtarget assignments)	1	cloned	No	Cj0367c	15791734		RND efflux system, membrane fusion prote...	367	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1T5E	29.2%	Campylobacter jejuni	Regulatory functions	Other

IDP01853 (show subtarget assignments)	1	cloned	No	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP90601 (show subtarget assignments)	0	work_stopped	No	YPO0643	16120968	rpoD	RNA polymerase sigma factor RpoD [Yersin...	612	Predicted Essential	Community Requests	3IYD	92%	Yersinia pestis

IDP90734 (show subtarget assignments)	8	selected	No	VC0517	15640541		RNA polymerase sigma factor RpoD [Vibrio...	625	Predicted Essential	Community Requests	3IYD	78.1%	Vibrio cholerae

IDP90733 (show subtarget assignments)	8	cloned	No	Cj1001	15792328	rpoD	RNA polymerase sigma factor RpoD [Campyl...	622	Predicted Essential	Community Requests	3IYD	35.9%	Campylobacter jejuni

IDP05057 (show subtarget assignments)	1	cloned	No	CD0266	126697838	fliA	RNA polymerase sigma factor for flagella...	233	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	38.2%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP91281 (show subtarget assignments)	8	expressed	No	NT05BA5437	49182125		RNA polymerase sigma-70 factor, ECF subf...	175	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1OR7	22.5%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP01177 (show subtarget assignments)	1	cloned	No	BA_4515	30259020	sigA	RNA polymerase sigma-43 factor	373	Conserved Gene / Pathway	Phase 2: March 2008	1L9U	51.2%	Bacillus anthracis	Transcription	Transcription factors

IDP01628 (show subtarget assignments)	1	cloned	No	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP91272 (show subtarget assignments)	8	cloned	No	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP91278 (show subtarget assignments)	8	cloned	No	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP92036 (show subtarget assignments)	8	selected	No	TGME49_033720	237837845		RNA polymerase, putative [Toxoplasma gon...	149	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F3I	36.9%	Toxoplasma gondii

IDP91416 (show subtarget assignments)	8	cloned	No	VV1_0692	27364149		RNA polymerase factor sigma-54 [Vibrio v...	487	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2AHQ	7.2%	Vibrio vulnificus

IDP02351 (show subtarget assignments)	1	cloned	No	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP02549 (show subtarget assignments)	1	purified	No	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP01987 (show subtarget assignments)	1	soluble	No	YPO0155	16120498	rpe	ribulose-phosphate 3-epimerase [Yersinia...	225	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3INP	63.1%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP92047 (show subtarget assignments)	8	selected	No	TGME49_047670	237835673		ribulose-phosphate 3-epimerase [Toxoplas...	230	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OVP	50%	Toxoplasma gondii

IDP90710 (show subtarget assignments)	8	crystallized	No	Cj0451	15791815	rep	ribulose-phosphate 3-epimerase [Campylob...	215	Predicted Essential	Community Requests	1RPX	48.4%	Campylobacter jejuni

IDP91595 (show subtarget assignments)	8	selected	No	AAC64366	3661463	arr-2	ribosylating transferase ARR-2 [Pseudomo...	150	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2HW2	51.3%	Pseudomonas aeruginosa

IDP04731 (show subtarget assignments)	1	crystallized	No	BAS3675	49186674		ribosome recycling factor [Bacillus anth...	185	Proposed to be essential proteins	Phase 4: April 2009	1IS1	50.8%	Bacillus anthracis

IDP00913 (show subtarget assignments)	0	work_stopped	No	STM0219	16763609	frr	ribosome recycling factor	185	Conserved Gene / Pathway	Phase 2: March 2008	1EK8	94.1%	Salmonella enterica	Protein synthesis	Translation factors

IDP91434 (show subtarget assignments)	8	soluble	No	VV1_0486	27363950		ribosome-associated protein Y [Vibrio vu...	107	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1IMU	50.5%	Vibrio vulnificus

IDP91404 (show subtarget assignments)	8	soluble	No	VV1_0879	27364327		ribosome-associated heat shock protein i...	128	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1DM9	64.8%	Vibrio vulnificus

IDP01031 (show subtarget assignments)	0	work_stopped	No	STM3497	16766785	yrfH	ribosome-associated heat shock protein H...	133	Conserved Gene / Pathway	Phase 2: March 2008	1DM9	95.5%	Salmonella enterica	Protein synthesis	Other

IDP04609 (show subtarget assignments)	1	soluble	No	BAS3712	49186711		ribosome-associated GTPase [Bacillus ant...	293	Proposed to be essential proteins	Phase 4: April 2009	1T9H	63.4%	Bacillus anthracis

IDP02683 (show subtarget assignments)	1	cloned	No	GBAA2008	47527306		ribosome-associated GTPase [Bacillus ant...	364	Conserved; Essential;	Phase 3: June 2008	1T9H	25.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04372 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0427	115346239	b4371	ribosomal RNA small subunit methyltransf...	347	conserved gene; putative drug target function;	Phase 4: April 2009	2PJD	68%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP92092 (show subtarget assignments)	8	selected	No	TGME49_020940	237841293		ribosomal RNA large subunit methyltransf...	342	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2PLW	25.7%	Toxoplasma gondii

IDP91447 (show subtarget assignments)	8	expressed	No	VV1_0393	27363861		ribosomal protein L22 [Vibrio vulnificus...	180	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DTE	18.3%	Vibrio vulnificus

IDP92052 (show subtarget assignments)	8	selected	No	TGME49_053800	237840277		ribosomal protein L15, putative [Toxopla...	287	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP91276 (show subtarget assignments)	8	soluble	No	NT05BA4392	49181134		ribosomal protein L11 methyltransferase ...	312	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3GRZ	26.9%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP91769 (show subtarget assignments)	8	soluble	No	YPTB1890	51596222	yjcK	ribosomal-protein-alanine acetyltransfer...	185	drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...	Community Requests	3R95	24.3%	Yersinia pseudotuberculosis

IDP04648 (show subtarget assignments)	1	selected	No	FTT1245	56708307	rluD	ribosomal large subunit pseudouridine sy...	332	drug target; conserved gene;	Phase 4: April 2009	1V9F	43.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04605 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3689	49186688		ribosomal biogenesis GTPase [Bacillus an...	296	Proposed to be essential proteins	Phase 4: April 2009	1PUJ	67.2%	Bacillus anthracis

IDP04170 (show subtarget assignments)	1	cloned	No	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01180 (show subtarget assignments)	1	cloned	No	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04206 (show subtarget assignments)	1	cloned	No	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90686 (show subtarget assignments)	8	crystallized	No	Cj0918c	15792247	prsA	ribose-phosphate pyrophosphokinase [Camp...	309	Predicted Essential	Community Requests	3DAH	57.1%	Campylobacter jejuni

IDP05406 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0669	30254269	rbsB	ribose ABC transporter, ribose-binding p...	308	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IOY	51.9%	Bacillus anthracis	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01508 (show subtarget assignments)	1	expressed	No	VCA0127	15600898		ribose ABC transporter protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	48.1%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP92040 (show subtarget assignments)	8	selected	No	TGME49_039310	237834547		ribose 5-phosphate isomerase, putative [...	259	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2F8M	42.5%	Toxoplasma gondii

IDP01719 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5560	47530880		ribose-5-phosphate isomerase B [Bacillus...	147	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HE8	55.1%	Bacillus anthracis	Energy metabolism	Sugars

IDP02119 (show subtarget assignments)	1	in_pdb 3KWM	No	FTT1208	56708271	rpiA	ribose-5-phosphate isomerase A [Francise...	224	Conserved; Drug target functions	Phase 3: June 2008	3KWM	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP90989 (show subtarget assignments)	8	soluble	No	y1222	22125124	nrdF	ribonucleotide-diphosphate reductase sub...	323	other biological interest / iron-regulated reductase	Community Requests	3N37	78.3%	Yersinia pestis

IDP02619 (show subtarget assignments)	1	cloned	No	GBAA1372	47526645	nrdF	ribonucleotide-diphosphate reductase sub...	322	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	4DR0	58.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP90990 (show subtarget assignments)	8	selected	No	y1223	22125125	nrdE	ribonucleotide-diphosphate reductase sub...	716	iron-regulated reductase	Community Requests	1PEM	72.6%	Yersinia pestis

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP90664 (show subtarget assignments)	8	cloned	No	Cj0024	15791423	nrdA	ribonucleotide-diphosphate reductase sub...	789	Predicted Essential	Community Requests	3HNC	33.7%	Campylobacter jejuni

IDP04416 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4049	49187047		ribonuclease Z [Bacillus anthracis str. ...	307	Proposed to be essential proteins	Phase 4: April 2009	1Y44	61.2%	Bacillus anthracis

IDP90731 (show subtarget assignments)	8	soluble	No	YPO4101	16124209	rnpA	ribonuclease P [Yersinia pestis CO92]	119	Predicted Essential	Community Requests	2LJP	89.1%	Yersinia pestis

IDP04690
(show subtarget assignments)

1

expressed

No

GBAA5029

47530328

sensor histidine kinase [Bacillus anthra...

418

putative drug target function;

Phase 4: April 2009

3D36

17.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04675
(show subtarget assignments)

1

soluble

No

GBAA2291

47527591

sensor histidine kinase [Bacillus anthra...

377

putative drug target function;

Phase 4: April 2009

3A0R

26.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04397
(show subtarget assignments)

1

expressed

No

GBAA3230

47528520

sensor histidine kinase [Bacillus anthra...

457

putative drug target function;

Phase 4: April 2009

2C2A

17.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01736
(show subtarget assignments)

1

expressed

No

GBAA5503

47530821

sensor histidine kinase [Bacillus anthra...

476

Conserved; Drug target functions

Phase 3: June 2008

2C2A

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02338
(show subtarget assignments)

1

cloned

No

GBAA1456

47526731

sensor histidine kinase [Bacillus anthra...

351

Conserved; Drug target functions

Phase 3: June 2008

3EHH

14.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04430
(show subtarget assignments)

1

purified

No

GBAA4921

47530215

sensor histidine kinase [Bacillus anthra...

484

putative drug target function;

Phase 4: April 2009

2C2A

16.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP90001
(show subtarget assignments)

8

cloned

No

FTT0094c

56603762

qseC

sensor histidine kinase

475

Drug Target (Community Request)

Community Requests

3A0R

15.8%

Francisella tularensis

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP02681
(show subtarget assignments)

1

soluble

No

STM3682

16766967

selB

selenocysteinyl-tRNA-specific translatio...

616

Conserved; Drug target functions

Phase 3: June 2008

1D8T

19%

Salmonella enterica

Protein synthesis

Translation factors

IDP02062
(show subtarget assignments)

1

soluble

No

CBU_1357

29541922

csdB

selenocysteine lyase [Coxiella burnetii ...

405

Conserved; Drug target functions

Phase 3: June 2008

1I29

50.9%

Coxiella burnetii

Central intermediary metabolism

Other

IDP91926
(show subtarget assignments)

8

selected

No

SpneCM_010100003840

298254733

scpB

segregation and condensation protein B [...

189

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2Z99

29.6%

Streptococcus pneumoniae

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP00631
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1537

57284636

scpB

segregation and condensation protein B

180

Conserved Gene / Pathway

Phase 2: March 2008

1T6S

23.9%

Staphylococcus aureus

Cellular processes

Cell division

IDP90286
(show subtarget assignments)

8

in_pdb
3UKS

No

TGME49_035700

211966629

sedoheptulose-1,7 bisphosphatase, putati...

330

Unpublished data indicate that the Calvin cycle enzyme sedoheptulose-1,7-bisphos...

Community Requests

3UKS

100%

Toxoplasma gondii

IDP04440
(show subtarget assignments)

1

cloned

No

YPO0266

115346083

secretion system apparatus protein [Yers...

682

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2X49

15.4%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90324
(show subtarget assignments)

8

expressed

No

CT088

15604807

sycE

secretion chaperone [Chlamydia trachomat...

146

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91363
(show subtarget assignments)

8

expressed

No

VV1_2834

27366116

secreted hydrolase [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ICH

28.6%

Vibrio vulnificus

IDP90106
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_011

68449085

secreted epidermal growth factor-like pr...

142

similar to VACV-COP-C11R, MPXV-ZAI96-D3R

Community Requests

1K36

16.2%

Monkeypox virus

IDP04697
(show subtarget assignments)

1

soluble

No

YPCD1.29c

16082717

yopB

secreted effector protein [Yersinia pest...

401

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01707
(show subtarget assignments)

1

crystallized

No

STM1631

16764975

sseJ

secreted effector protein [Salmonella ty...

408

VIRULENCE FACTOR

Phase 3: June 2008

3CXB

10%

Salmonella enterica

N/A

IDP01023
(show subtarget assignments)

1

in_crystallization_trials

No

STM1051

16764411

sseI

secreted effector protein [Phage Gifsy-2...

322

Virulence Associated Factor

Phase 2: March 2008

3CXB

15.8%

Salmonella enterica

Unknown function

General

IDP01014
(show subtarget assignments)

1

in_crystallization_trials

No

STM2780

16766091

pipB2

secreted effector protein

350

Virulence Associated Factor

Phase 2: March 2008

2LEZ

41.4%

Salmonella enterica

Unknown function

General

IDP05583
(show subtarget assignments)

1

soluble

No

BA_2249

30256893

SCO1/SenC family lipoprotein [Bacillus a...

195

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XZO

45.6%

Bacillus anthracis

Unknown function: General

IDP02514
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0116

29540736

mraW

S-adenosyl-methyltransferase MraW [Coxie...

307

Conserved; Drug target functions

Phase 3: June 2008

1WG8

46.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP05529
(show subtarget assignments)

1

cloned

No

CD2658

126700272

mraW

S-adenosyl-methyltransferase [Clostridiu...

318

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WG8

41.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04616
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4313

49187308

S-adenosylmethionine:tRNA ribosyltransfe...

350

Proposed to be essential proteins

Phase 4: April 2009

1YY3

71.4%

Bacillus anthracis

IDP90798
(show subtarget assignments)

8

in_crystallization_trials

No

VC0472

15640499

S-adenosylmethionine synthetase [Vibrio ...

385

Predicted Essential

Community Requests

1FUG

87.5%

Vibrio cholerae

IDP92043
(show subtarget assignments)

8

selected

No

TGME49_040690

237834781

S-adenosylmethionine synthetase, putativ...

415

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2P02

60.5%

Toxoplasma gondii

IDP90872
(show subtarget assignments)

8

expressed

No

Cj1096c

15792421

metK

S-adenosylmethionine synthetase [Campylo...

398

Predicted Essential

Community Requests

3IML

41.7%

Campylobacter jejuni

IDP01626
(show subtarget assignments)

1

cloned

No

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00748
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1837

57284761

metK

S-adenosylmethionine synthetase

397

Drug Target Function

Phase 2: March 2008

1FUG

62.2%

Staphylococcus aureus

Central intermediary metabolism

One-carbon metabolism

IDP90538
(show subtarget assignments)

8

soluble

No

YPO3412

16123561

speD

S-adenosylmethionine decarboxylase [Yers...

264

Predicted Essential

Community Requests

Yersinia pestis

IDP92073
(show subtarget assignments)

8

selected

No

TGME49_088860

237838049

ruvB-like 2 protein, putative [Toxoplasm...

508

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2XSZ

49.2%

Toxoplasma gondii

IDP92077
(show subtarget assignments)

8

selected

No

TGME49_097370

237843739

ruvB-like 1, putative [Toxoplasma gondii...

463

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

62.9%

Toxoplasma gondii

IDP92030
(show subtarget assignments)

8

selected

No

TGME49_019590

237842827

ruvB-like 1, putative [Toxoplasma gondii...

492

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

55.9%

Toxoplasma gondii

IDP90973
(show subtarget assignments)

8

selected

No

AND4_00045

163803697

RTX toxin RtxA [Vibrio sp. AND4]

525

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Vibrio sp.

IDP00167
(show subtarget assignments)

8

in_pdb
3FZY

Yes

VC1451

4455065

rtxA

RTX toxin RtxA

4545

Virulence

Community Requests

3EEB

4.6%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00166
(show subtarget assignments)

1

expressed

No

VC1450

15641461

rtxC

RTX toxin activating protein

153

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02236
(show subtarget assignments)

1

cloned

No

FTT1108

56708186

rRNA methyltransferase [Francisella tula...

250

Drug Target

Phase 3: June 2008

1IPA

29.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP90535
(show subtarget assignments)

8

soluble

No

VC2695

15642690

rRNA methylase [Vibrio cholerae O1 biova...

158

Predicted Essential

Community Requests

3N4J

58.5%

Vibrio cholerae

IDP91589
(show subtarget assignments)

8

expressed

No

BAB41266

13699967

ermA

rRNA methylase [Staphylococcus aureus su...

243

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP91784
(show subtarget assignments)

8

soluble

No

SA1480

15927234

ermA

rRNA methylase Erm(A) [Staphylococcus au...

243

drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP02288
(show subtarget assignments)

1

cloned

No

FTT0932

56708030

ROK family protein [Francisella tularens...

283

Drug Target

Phase 3: June 2008

2YHY

29.2%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00802
(show subtarget assignments)

1

cloned

No

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04193
(show subtarget assignments)

1

cloned

No

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP05022
(show subtarget assignments)

1

cloned

No

CD1145

126698740

mreB2

rod shape-determining protein MreB [Clos...

353

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

54.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01231
(show subtarget assignments)

1

purified

No

BA_4684

30259179

mreB

rod shape-determining protein MreB

339

Drug Target Function

Phase 2: March 2008

1JCE

52.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05051
(show subtarget assignments)

1

cloned

No

CD0127

126697699

mreB1

rod shape-determining protein Mbl [Clost...

339

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

52.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02813
(show subtarget assignments)

1

cloned

No

Cj0367c

15791734

RND efflux system, membrane fusion prote...

367

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1T5E

29.2%

Campylobacter jejuni

Regulatory functions

Other

IDP01853
(show subtarget assignments)

1

cloned

No

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP90601
(show subtarget assignments)

0

work_stopped

No

YPO0643

16120968

rpoD

RNA polymerase sigma factor RpoD [Yersin...

612

Predicted Essential

Community Requests

3IYD

92%

Yersinia pestis

IDP90734
(show subtarget assignments)

8

selected

No

VC0517

15640541

RNA polymerase sigma factor RpoD [Vibrio...

625

Predicted Essential

Community Requests

3IYD

78.1%

Vibrio cholerae

IDP90733
(show subtarget assignments)

8

cloned

No

Cj1001

15792328

rpoD

RNA polymerase sigma factor RpoD [Campyl...

622

Predicted Essential

Community Requests

3IYD

35.9%

Campylobacter jejuni

IDP05057
(show subtarget assignments)

1

cloned

No

CD0266

126697838

fliA

RNA polymerase sigma factor for flagella...

233

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

38.2%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP91281
(show subtarget assignments)

8

expressed

No

NT05BA5437

49182125

RNA polymerase sigma-70 factor, ECF subf...

175

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1OR7

22.5%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP01177
(show subtarget assignments)

1

cloned

No

BA_4515

30259020

sigA

RNA polymerase sigma-43 factor

373

Conserved Gene / Pathway

Phase 2: March 2008

1L9U

51.2%

Bacillus anthracis

Transcription

Transcription factors

IDP01628
(show subtarget assignments)

1

cloned

No

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP91272
(show subtarget assignments)

8

cloned

No

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP91278
(show subtarget assignments)

8

cloned

No

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP92036
(show subtarget assignments)

8

selected

No

TGME49_033720

237837845

RNA polymerase, putative [Toxoplasma gon...

149

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F3I

36.9%

Toxoplasma gondii

IDP91416
(show subtarget assignments)

8

cloned

No

VV1_0692

27364149

RNA polymerase factor sigma-54 [Vibrio v...

487

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2AHQ

7.2%

Vibrio vulnificus

IDP02351
(show subtarget assignments)

1

cloned

No

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP02549
(show subtarget assignments)

1

purified

No

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP01987
(show subtarget assignments)

1

soluble

No

YPO0155

16120498

rpe

ribulose-phosphate 3-epimerase [Yersinia...

225

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3INP

63.1%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP92047
(show subtarget assignments)

8

selected

No

TGME49_047670

237835673

ribulose-phosphate 3-epimerase [Toxoplas...

230

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OVP

50%

Toxoplasma gondii

IDP90710
(show subtarget assignments)

8

crystallized

No

Cj0451

15791815

rep

ribulose-phosphate 3-epimerase [Campylob...

215

Predicted Essential

Community Requests

1RPX

48.4%

Campylobacter jejuni

IDP91595
(show subtarget assignments)

8

selected

No

AAC64366

3661463

arr-2

ribosylating transferase ARR-2 [Pseudomo...

150

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2HW2

51.3%

Pseudomonas aeruginosa

IDP04731
(show subtarget assignments)

1

crystallized

No

BAS3675

49186674

ribosome recycling factor [Bacillus anth...

185

Proposed to be essential proteins

Phase 4: April 2009

1IS1

50.8%

Bacillus anthracis

IDP00913
(show subtarget assignments)

0

work_stopped

No

STM0219

16763609

frr

ribosome recycling factor

185

Conserved Gene / Pathway

Phase 2: March 2008

1EK8

94.1%

Salmonella enterica

Protein synthesis

Translation factors

IDP91434
(show subtarget assignments)

8

soluble

No

VV1_0486

27363950

ribosome-associated protein Y [Vibrio vu...

107

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1IMU

50.5%

Vibrio vulnificus

IDP91404
(show subtarget assignments)

8

soluble

No

VV1_0879

27364327

ribosome-associated heat shock protein i...

128

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1DM9

64.8%

Vibrio vulnificus

IDP01031
(show subtarget assignments)

0

work_stopped

No

STM3497

16766785

yrfH

ribosome-associated heat shock protein H...

133

Conserved Gene / Pathway

Phase 2: March 2008

1DM9

95.5%

Salmonella enterica

Protein synthesis

Other

IDP04609
(show subtarget assignments)

1

soluble

No

BAS3712

49186711

ribosome-associated GTPase [Bacillus ant...

293

Proposed to be essential proteins

Phase 4: April 2009

1T9H

63.4%

Bacillus anthracis

IDP02683
(show subtarget assignments)

1

cloned

No

GBAA2008

47527306

ribosome-associated GTPase [Bacillus ant...

364

Conserved; Essential;

Phase 3: June 2008

1T9H

25.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04372
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0427

115346239

b4371

ribosomal RNA small subunit methyltransf...

347

conserved gene; putative drug target function;

Phase 4: April 2009

2PJD

68%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP92092
(show subtarget assignments)

8

selected

No

TGME49_020940

237841293

ribosomal RNA large subunit methyltransf...

342

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2PLW

25.7%

Toxoplasma gondii

IDP91447
(show subtarget assignments)

8

expressed

No

VV1_0393

27363861

ribosomal protein L22 [Vibrio vulnificus...

180

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DTE

18.3%

Vibrio vulnificus

IDP92052
(show subtarget assignments)

8

selected

No

TGME49_053800

237840277

ribosomal protein L15, putative [Toxopla...

287

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP91276
(show subtarget assignments)

8

soluble

No

NT05BA4392

49181134

ribosomal protein L11 methyltransferase ...

312

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3GRZ

26.9%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP91769
(show subtarget assignments)

8

soluble

No

YPTB1890

51596222

yjcK

ribosomal-protein-alanine acetyltransfer...

185

drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...

Community Requests

3R95

24.3%

Yersinia pseudotuberculosis

IDP04648
(show subtarget assignments)

1

selected

No

FTT1245

56708307

rluD

ribosomal large subunit pseudouridine sy...

332

drug target; conserved gene;

Phase 4: April 2009

1V9F

43.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04605
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3689

49186688

ribosomal biogenesis GTPase [Bacillus an...

296

Proposed to be essential proteins

Phase 4: April 2009

1PUJ

67.2%

Bacillus anthracis

IDP04170
(show subtarget assignments)

1

cloned

No

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01180
(show subtarget assignments)

1

cloned

No

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04206
(show subtarget assignments)

1

cloned

No

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90686
(show subtarget assignments)

8

crystallized

No

Cj0918c

15792247

prsA

ribose-phosphate pyrophosphokinase [Camp...

309

Predicted Essential

Community Requests

3DAH

57.1%

Campylobacter jejuni

IDP05406
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0669

30254269

rbsB

ribose ABC transporter, ribose-binding p...

308

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IOY

51.9%

Bacillus anthracis

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01508
(show subtarget assignments)

1

expressed

No

VCA0127

15600898

ribose ABC transporter protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

48.1%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP92040
(show subtarget assignments)

8

selected

No

TGME49_039310

237834547

ribose 5-phosphate isomerase, putative [...

259

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2F8M

42.5%

Toxoplasma gondii

IDP01719
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5560

47530880

ribose-5-phosphate isomerase B [Bacillus...

147

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HE8

55.1%

Bacillus anthracis

Energy metabolism

Sugars

IDP02119
(show subtarget assignments)

1

in_pdb
3KWM

No

FTT1208

56708271

rpiA

ribose-5-phosphate isomerase A [Francise...

224

Conserved; Drug target functions

Phase 3: June 2008

3KWM

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP90989
(show subtarget assignments)

8

soluble

No

y1222

22125124

nrdF

ribonucleotide-diphosphate reductase sub...

323

other biological interest / iron-regulated reductase

Community Requests

3N37

78.3%

Yersinia pestis

IDP02619
(show subtarget assignments)

1

cloned

No

GBAA1372

47526645

nrdF

ribonucleotide-diphosphate reductase sub...

322

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

4DR0

58.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP90990
(show subtarget assignments)

8

selected

No

y1223

22125125

nrdE

ribonucleotide-diphosphate reductase sub...

716

iron-regulated reductase

Community Requests

1PEM

72.6%

Yersinia pestis

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP90664
(show subtarget assignments)

8

cloned

No

Cj0024

15791423

nrdA

ribonucleotide-diphosphate reductase sub...

789

Predicted Essential

Community Requests

3HNC

33.7%

Campylobacter jejuni

IDP04416
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4049

49187047

ribonuclease Z [Bacillus anthracis str. ...

307

Proposed to be essential proteins

Phase 4: April 2009

1Y44

61.2%

Bacillus anthracis

IDP90731
(show subtarget assignments)

8

soluble

No

YPO4101

16124209

rnpA

ribonuclease P [Yersinia pestis CO92]

119

Predicted Essential

Community Requests

2LJP

89.1%

Yersinia pestis