Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01001 (show subtarget assignments)	1	soluble	No	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01002 (show subtarget assignments)	1	in_pdb 3ERP	Yes	STM2406	16765732		putative oxidoreductase	332	Essential Gene	Phase 2: March 2008	3ERP	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00028 (show subtarget assignments)	1	purified	No	BA_0401	30253936		tellurium resistance protein	194	Virulence	Phase 1: October 2007	2KXT	57.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02222 (show subtarget assignments)	1	crystallized	No	lmo0484	16802527		heme-degrading monooxygenase IsdG [Liste...	121	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1TZ0	28.9%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP01965 (show subtarget assignments)	1	cloned	No	STM1786	16765127		hydrogenase-1 small subunit [Salmonella ...	372	Conserved; Drug target functions	Phase 3: June 2008	3UQY	80.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01777 (show subtarget assignments)	1	cloned	No	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00114 (show subtarget assignments)	1	purified	No	GVCV52ORF0478	9654887		Vibrio cholerae O1 biovar eltor str. N16...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3JVU	65.8%	Vibrio cholerae	Cell envelope	Surface structures

IDP02072 (show subtarget assignments)	1	soluble	No	FTT0554	56707684		hypothetical protein FTT0554 [Francisell...	90	Drug Target	Phase 3: June 2008	4ADZ	35.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01649 (show subtarget assignments)	1	expressed	No	CBU_0796	29541390		HIT family protein [Coxiella burnetii RS...	113	Conserved; Drug target functions	Phase 3: June 2008	1AV5	49.6%	Coxiella burnetii	Unknown function	General

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02258 (show subtarget assignments)	1	cloned	No	Cj0178	15791565		putative outer membrane siderophore rece...	755	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3CSL	24.9%	Campylobacter jejuni	Cell envelope	Other

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01683 (show subtarget assignments)	1	expressed	No	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01173 (show subtarget assignments)	1	cloned	No	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02275 (show subtarget assignments)	1	cloned	No	FTT1158c	56708229		Type IV pili glycosylation protein [Fran...	198	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis,Cell adhesion

IDP01026 (show subtarget assignments)	1	cloned	No	STM1267	16764618		putative cytoplasmic protein	82	Conserved Gene / Pathway	Phase 2: March 2008	2OXL	32.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00251 (show subtarget assignments)	1	cloned	No	MVEVgp1	9633623		Murray Valley encephalitis Envelope prot...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	78.1%	Murray Valley

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00252 (show subtarget assignments)	1	in_crystallization_trials	No		130516		St. Louis encephalitis virus Envelope pr...	407	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	2I69	70.5%	St. Louis

IDP01315 (show subtarget assignments)	1	cloned	No	VC0942	15640958		hypothetical protein VC0942	117	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01918 (show subtarget assignments)	1	cloned	No	lmo0514	16802557		hypothetical protein lmo0514 [Listeria m...	605	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	2OMZ	17.7%	Listeria monocytogenes	Cell envelope	Other

IDP01134 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2001	30256654		intracellular serine protease	316	Drug Target Function	Phase 2: March 2008	2WV7	52.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00253 (show subtarget assignments)	1	in_crystallization_trials	No	YFVgp1	9627245		Yellow fever virus Envelope protein	399	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1P58	43.8%	Yellow fever

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00029 (show subtarget assignments)	1	purified	No	BA_0404	30253939		tellurite resistance protein, putative	360	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01135 (show subtarget assignments)	1	expressed	No	BA_3911	30258425		renal dipeptidase family protein	307	Drug Target Function	Phase 2: March 2008	3LU2	45.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00254 (show subtarget assignments)	1	in_pdb 3P54	Yes		13272205		Japanese encephalitis virus Envelope pro...	406	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	3P54	98.3%	Japanese encephalitis

IDP01973 (show subtarget assignments)	1	expressed	No	Cj1440c	15792758		putative sugar transferase [Campylobacte...	407	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2Z86	15.5%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01662 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2583	16804621		hypothetical protein lmo2583 [Listeria m...	225	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	39.1%	Listeria monocytogenes	Regulatory functions	Other

IDP01164 (show subtarget assignments)	1	purified	No	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP01764 (show subtarget assignments)	1	cloned	No	Cj1434c	15792752		putative sugar transferase [Campylobacte...	445	Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...	Phase 3: June 2008	3L7I	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01181 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0085	38372318		2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	3F6M	64.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP01047 (show subtarget assignments)	1	cloned	No	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	34.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP01316 (show subtarget assignments)	1	in_crystallization_trials	No	VC1616	15641624		glutaredoxin, putative	77	Conserved Gene / Pathway	Phase 2: March 2008	2KLX	32.5%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00257 (show subtarget assignments)	1	in_crystallization_trials	No	MODVgp1	20177456		Modoc virus Envelope protein	393	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1SVB	41%	Modoc virus

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01684 (show subtarget assignments)	1	soluble	No	YPO3559	16123703		hypothetical protein YPO3559 [Yersinia p...	161	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00258 (show subtarget assignments)	1	in_crystallization_trials	No	MMLVgp1	22550316		Montana myotis leukoencephalitis Envelop...	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.6%	Montana myotis

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01673 (show subtarget assignments)	1	purified	No	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	3SLU	25.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01704 (show subtarget assignments)	1	expressed	No	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00060 (show subtarget assignments)	1	in_pdb 3UH9	Yes	BA_4109	46395774		Metallothiol transferase fosB 2 (Fosfomy...	139	Virulence	Phase 1: October 2007	3UH9	100%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01483 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0180	15600950		peptidase T	410	Drug Target Function	Phase 2: March 2008	1VIX	57.6%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01721 (show subtarget assignments)	1	cloned	No	Cj1031	15792358		putative outer membrane component of eff...	424	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	2VDD	21.4%	Campylobacter jejuni	Regulatory functions	Other

IDP01310 (show subtarget assignments)	1	purified	No	VC2251	15642249		outer membrane protein OmpH	169	Conserved Gene / Pathway	Phase 2: March 2008	1SG2	30.2%	Vibrio cholerae	Cell envelope	Other

IDP01484 (show subtarget assignments)	1	in_pdb 4EH1	No	VCA0183	15600953		nitric oxide dioxygenase	394	Conserved Gene / Pathway	Phase 2: March 2008	4EH1	61.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01347 (show subtarget assignments)	1	purified	No	VC2421	15642418		N-acetyl-anhydromuranmyl-L-alanine amida...	181	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	63%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01167 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP01352 (show subtarget assignments)	1	soluble	No	VCA0447	15601210		haemagglutinin associated protein	230	Conserved Gene / Pathway	Phase 2: March 2008	1G60	29.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00030 (show subtarget assignments)	1	purified	No	BA_0926	30254669		tellurium resistance protein, putative	401	Virulence	Phase 1: October 2007	2KXT	16%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01156 (show subtarget assignments)	1	expressed	No	BA_0798	30254389		ABC transporter, ATP-binding protein	224	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	50.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01625 (show subtarget assignments)	1	expressed	No	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	Phase 3: June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01144 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP01412 (show subtarget assignments)	1	purified	No	VC1122	15641135		cyclopropane-fatty-acyl-phospholipid syn...	432	Drug Target Function	Phase 2: March 2008	1KPI	18.7%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01073 (show subtarget assignments)	1	purified	No	STM4044	16767310		putative alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	42.6%	Salmonella enterica	Energy metabolism	Fermentation

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00061 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4399	30258896		hemolysin A	279	Virulence	Phase 1: October 2007	3HP7	58.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01442 (show subtarget assignments)	1	expressed	No	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01377 (show subtarget assignments)	1	cloned	No	VC0409	15640436		MSHA pilin protein MshA	178	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01081 (show subtarget assignments)	1	soluble	No	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	28.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01342 (show subtarget assignments)	1	soluble	No	VC1960	15641962		septum site-determining protein MinD	276	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	73.6%	Vibrio cholerae	Cellular processes	Cell division

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP02064 (show subtarget assignments)	1	cloned	No	YPO3878	16124011		putative fimbrial chaperone [Yersinia pe...	243	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.5%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP01180 (show subtarget assignments)	1	cloned	No	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01926 (show subtarget assignments)	1	cloned	No	lmo0931	16802971		hypothetical protein lmo0931 [Listeria m...	331	Known virulence-Intracellular Survival; PMID:17908209	Phase 3: June 2008	1VQZ	44.7%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP01087 (show subtarget assignments)	1	cloned	No	STM4465	16767710		ornithine carbamoyltransferase	334	Conserved Gene / Pathway	Phase 2: March 2008	3UPD	75.7%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP00573 (show subtarget assignments)	1	in_pdb 3GO9	No	YPO3991	16124118		putative insulinase family protease	499	Drug Target Function	Phase 2: March 2008	3GO9	98.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01168 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0084	47566748		capsule synthesis trans-acting positive ...	483	Virulence Associated Factor	Phase 2: March 2008	3SQN	8.5%	Bacillus anthracis

IDP00062 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4511	50400989		4-hydroxy-3-methylbut-2-enyl diphosphate...	316	Virulence	Phase 1: October 2007	3F7T	35.4%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01101 (show subtarget assignments)	1	expressed	No	GBAA_pXO1_0119	47566439		hypothetical protein GBAA_pXO1_0119	82	Virulence Associated Factor	Phase 2: March 2008	3SIK	52.4%	Bacillus anthracis

IDP01102 (show subtarget assignments)	1	soluble	No	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01103 (show subtarget assignments)	1	cloned	No	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01105 (show subtarget assignments)	1	purified	No	BA_2788	67460529		ATP-dependent Clp protease proteolytic s...	193	Drug Target Function	Phase 2: March 2008	3TT7	67.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01392 (show subtarget assignments)	1	purified	No	VC0648	15640668		lipoprotein NlpI	303	Conserved Gene / Pathway	Phase 2: March 2008	1XNF	44.2%	Vibrio cholerae	Cell envelope	Other

IDP02737 (show subtarget assignments)	1	expressed	No	GBAA1974	47527269		putative lipoprotein [Bacillus anthracis...	415	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Other

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP01001
(show subtarget assignments)

1

soluble

No

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01002
(show subtarget assignments)

1

in_pdb
3ERP

Yes

STM2406

16765732

putative oxidoreductase

332

Essential Gene

Phase 2: March 2008

3ERP

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00028
(show subtarget assignments)

1

purified

No

BA_0401

30253936

tellurium resistance protein

194

Virulence

Phase 1: October 2007

2KXT

57.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02222
(show subtarget assignments)

1

crystallized

No

lmo0484

16802527

heme-degrading monooxygenase IsdG [Liste...

121

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1TZ0

28.9%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP01965
(show subtarget assignments)

1

cloned

No

STM1786

16765127

hydrogenase-1 small subunit [Salmonella ...

372

Conserved; Drug target functions

Phase 3: June 2008

3UQY

80.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01777
(show subtarget assignments)

1

cloned

No

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00114
(show subtarget assignments)

1

purified

No

GVCV52ORF0478

9654887

Vibrio cholerae O1 biovar eltor str. N16...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3JVU

65.8%

Vibrio cholerae

Cell envelope

Surface structures

IDP02072
(show subtarget assignments)

1

soluble

No

FTT0554

56707684

hypothetical protein FTT0554 [Francisell...

90

Drug Target

Phase 3: June 2008

4ADZ

35.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01649
(show subtarget assignments)

1

expressed

No

CBU_0796

29541390

HIT family protein [Coxiella burnetii RS...

113

Conserved; Drug target functions

Phase 3: June 2008

1AV5

49.6%

Coxiella burnetii

Unknown function

General

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02258
(show subtarget assignments)

1

cloned

No

Cj0178

15791565

putative outer membrane siderophore rece...

755

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3CSL

24.9%

Campylobacter jejuni

Cell envelope

Other

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01683
(show subtarget assignments)

1

expressed

No

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01173
(show subtarget assignments)

1

cloned

No

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02275
(show subtarget assignments)

1

cloned

No

FTT1158c

56708229

Type IV pili glycosylation protein [Fran...

198

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis,Cell adhesion

IDP01026
(show subtarget assignments)

1

cloned

No

STM1267

16764618

putative cytoplasmic protein

82

Conserved Gene / Pathway

Phase 2: March 2008

2OXL

32.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00251
(show subtarget assignments)

1

cloned

No

MVEVgp1

9633623

Murray Valley encephalitis Envelope prot...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

78.1%

Murray Valley

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00252
(show subtarget assignments)

1

in_crystallization_trials

No

130516

St. Louis encephalitis virus Envelope pr...

407

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

2I69

70.5%

St. Louis

IDP01315
(show subtarget assignments)

1

cloned

No

VC0942

15640958

hypothetical protein VC0942

117

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01918
(show subtarget assignments)

1

cloned

No

lmo0514

16802557

hypothetical protein lmo0514 [Listeria m...

605

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

2OMZ

17.7%

Listeria monocytogenes

Cell envelope

Other

IDP01134
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2001

30256654

intracellular serine protease

316

Drug Target Function

Phase 2: March 2008

2WV7

52.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00253
(show subtarget assignments)

1

in_crystallization_trials

No

YFVgp1

9627245

Yellow fever virus Envelope protein

399

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1P58

43.8%

Yellow fever

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00029
(show subtarget assignments)

1

purified

No

BA_0404

30253939

tellurite resistance protein, putative

360

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01135
(show subtarget assignments)

1

expressed

No

BA_3911

30258425

renal dipeptidase family protein

307

Drug Target Function

Phase 2: March 2008

3LU2

45.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00254
(show subtarget assignments)

1

in_pdb
3P54

Yes

13272205

Japanese encephalitis virus Envelope pro...

406

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

3P54

98.3%

Japanese encephalitis

IDP01973
(show subtarget assignments)

1

expressed

No

Cj1440c

15792758

putative sugar transferase [Campylobacte...

407

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2Z86

15.5%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01662
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2583

16804621

hypothetical protein lmo2583 [Listeria m...

225

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

39.1%

Listeria monocytogenes

Regulatory functions

Other

IDP01164
(show subtarget assignments)

1

purified

No

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP01764
(show subtarget assignments)

1

cloned

No

Cj1434c

15792752

putative sugar transferase [Campylobacte...

445

Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...

Phase 3: June 2008

3L7I

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01181
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0085

38372318

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

3F6M

64.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP01047
(show subtarget assignments)

1

cloned

No

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

34.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP01316
(show subtarget assignments)

1

in_crystallization_trials

No

VC1616

15641624

glutaredoxin, putative

77

Conserved Gene / Pathway

Phase 2: March 2008

2KLX

32.5%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00257
(show subtarget assignments)

1

in_crystallization_trials

No

MODVgp1

20177456

Modoc virus Envelope protein

393

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1SVB

41%

Modoc virus

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01684
(show subtarget assignments)

1

soluble

No

YPO3559

16123703

hypothetical protein YPO3559 [Yersinia p...

161

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00258
(show subtarget assignments)

1

in_crystallization_trials

No

MMLVgp1

22550316

Montana myotis leukoencephalitis Envelop...

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.6%

Montana myotis

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01673
(show subtarget assignments)

1

purified

No

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

3SLU

25.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01704
(show subtarget assignments)

1

expressed

No

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00060
(show subtarget assignments)

1

in_pdb
3UH9

Yes

BA_4109

46395774

Metallothiol transferase fosB 2 (Fosfomy...

139

Virulence

Phase 1: October 2007

3UH9

100%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01483
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0180

15600950

peptidase T

410

Drug Target Function

Phase 2: March 2008

1VIX

57.6%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01721
(show subtarget assignments)

1

cloned

No

Cj1031

15792358

putative outer membrane component of eff...

424

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

2VDD

21.4%

Campylobacter jejuni

Regulatory functions

Other

IDP01310
(show subtarget assignments)

1

purified

No

VC2251

15642249

outer membrane protein OmpH

169

Conserved Gene / Pathway

Phase 2: March 2008

1SG2

30.2%

Vibrio cholerae

Cell envelope

Other

IDP01484
(show subtarget assignments)

1

in_pdb
4EH1

No

VCA0183

15600953

nitric oxide dioxygenase

394

Conserved Gene / Pathway

Phase 2: March 2008

4EH1

61.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01347
(show subtarget assignments)

1

purified

No

VC2421

15642418

N-acetyl-anhydromuranmyl-L-alanine amida...

181

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

63%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01167
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP01352
(show subtarget assignments)

1

soluble

No

VCA0447

15601210

haemagglutinin associated protein

230

Conserved Gene / Pathway

Phase 2: March 2008

1G60

29.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00030
(show subtarget assignments)

1

purified

No

BA_0926

30254669

tellurium resistance protein, putative

401

Virulence

Phase 1: October 2007

2KXT

16%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01156
(show subtarget assignments)

1

expressed

No

BA_0798

30254389

ABC transporter, ATP-binding protein

224

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

50.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01625
(show subtarget assignments)

1

expressed

No

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

Phase 3: June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01144
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP01412
(show subtarget assignments)

1

purified

No

VC1122

15641135

cyclopropane-fatty-acyl-phospholipid syn...

432

Drug Target Function

Phase 2: March 2008

1KPI

18.7%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01073
(show subtarget assignments)

1

purified

No

STM4044

16767310

putative alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

42.6%

Salmonella enterica

Energy metabolism

Fermentation

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00061
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4399

30258896

hemolysin A

279

Virulence

Phase 1: October 2007

3HP7

58.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01442
(show subtarget assignments)

1

expressed

No

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01377
(show subtarget assignments)

1

cloned

No

VC0409

15640436

MSHA pilin protein MshA

178

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01081
(show subtarget assignments)

1

soluble

No

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

28.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01342
(show subtarget assignments)

1

soluble

No

VC1960

15641962

septum site-determining protein MinD

276

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

73.6%

Vibrio cholerae

Cellular processes

Cell division

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP02064
(show subtarget assignments)

1

cloned

No

YPO3878

16124011

putative fimbrial chaperone [Yersinia pe...

243

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.5%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP01180
(show subtarget assignments)

1

cloned

No

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01926
(show subtarget assignments)

1

cloned

No

lmo0931

16802971

hypothetical protein lmo0931 [Listeria m...

331

Known virulence-Intracellular Survival; PMID:17908209

Phase 3: June 2008

1VQZ

44.7%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP01087
(show subtarget assignments)

1

cloned

No

STM4465

16767710

ornithine carbamoyltransferase

334

Conserved Gene / Pathway

Phase 2: March 2008

3UPD

75.7%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP00573
(show subtarget assignments)

1

in_pdb
3GO9

No

YPO3991

16124118

putative insulinase family protease

499

Drug Target Function

Phase 2: March 2008

3GO9

98.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01168
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0084

47566748

capsule synthesis trans-acting positive ...

483

Virulence Associated Factor

Phase 2: March 2008

3SQN

8.5%

Bacillus anthracis

IDP00062
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4511

50400989

4-hydroxy-3-methylbut-2-enyl diphosphate...

316

Virulence

Phase 1: October 2007

3F7T

35.4%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01101
(show subtarget assignments)

1

expressed

No

GBAA_pXO1_0119

47566439

hypothetical protein GBAA_pXO1_0119

82

Virulence Associated Factor

Phase 2: March 2008

3SIK

52.4%

Bacillus anthracis

IDP01102
(show subtarget assignments)

1

soluble

No

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01103
(show subtarget assignments)

1

cloned

No

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01105
(show subtarget assignments)

1

purified

No

BA_2788

67460529

ATP-dependent Clp protease proteolytic s...

193

Drug Target Function

Phase 2: March 2008

3TT7

67.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01392
(show subtarget assignments)

1

purified

No

VC0648

15640668

lipoprotein NlpI

303

Conserved Gene / Pathway

Phase 2: March 2008

1XNF

44.2%

Vibrio cholerae

Cell envelope

Other

IDP02737
(show subtarget assignments)

1

expressed

No

GBAA1974

47527269

putative lipoprotein [Bacillus anthracis...

415

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Other

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

Targets