Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04601 (show subtarget assignments)	1	in_pdb 3RHI	Yes	BAS3574	49186575		DNA-binding protein HU [Bacillus anthrac...	90	Proposed to be essential proteins	Phase 4: April 2009	3RHI	100%	Bacillus anthracis

IDP04603 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3670	49186669		prolyl-tRNA synthetase [Bacillus anthrac...	566	Proposed to be essential proteins	Phase 4: April 2009	2J3L	58.1%	Bacillus anthracis

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04604 (show subtarget assignments)	1	cloned	No	BAS3678	49186677		30S ribosomal protein S2 [Bacillus anthr...	233	Proposed to be essential proteins	Phase 4: April 2009	1FJG	56.2%	Bacillus anthracis

IDP04612 (show subtarget assignments)	1	cloned	No	BAS3764	49186763		phospho-N-acetylmuramoyl-pentapeptide-tr...	324	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP04593 (show subtarget assignments)	1	cloned	No	BAS0144	49183178		30S ribosomal protein S9 [Bacillus anthr...	130	Proposed to be essential proteins	Phase 4: April 2009	1VS5	55.4%	Bacillus anthracis

IDP04592 (show subtarget assignments)	1	expressed	No	BAS0143	49183177		50S ribosomal protein L13 [Bacillus anth...	145	Proposed to be essential proteins	Phase 4: April 2009	1P85	56.6%	Bacillus anthracis

IDP04595 (show subtarget assignments)	1	soluble	No	BAS0565	49183590		nicotinate phosphoribosyltransferase [Ba...	487	Proposed to be essential proteins	Phase 4: April 2009	2F7F	61.4%	Bacillus anthracis

IDP04590 (show subtarget assignments)	1	expressed	No	BAS0136	49183170		30S ribosomal protein S11 [Bacillus anth...	129	Proposed to be essential proteins	Phase 4: April 2009	1VS5	65.9%	Bacillus anthracis

IDP04589 (show subtarget assignments)	1	expressed	No	BAS0135	49183169		30S ribosomal protein S13 [Bacillus anth...	121	Proposed to be essential proteins	Phase 4: April 2009	1FJG	63.9%	Bacillus anthracis

IDP04591 (show subtarget assignments)	1	cloned	No	BAS0138	49183172		50S ribosomal protein L17 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1NKW	50.8%	Bacillus anthracis

IDP04596 (show subtarget assignments)	1	in_crystallization_trials	No	BAS1099	49184119		tryptophanyl-tRNA synthetase [Bacillus a...	329	Proposed to be essential proteins	Phase 4: April 2009	3PRH	73.9%	Bacillus anthracis

IDP04586 (show subtarget assignments)	1	cloned	No	BAS0117	49183151		50S ribosomal protein L16 [Bacillus anth...	144	Proposed to be essential proteins	Phase 4: April 2009	1VSA	60.4%	Bacillus anthracis

IDP04585 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0116	49183150		30S ribosomal protein S3 [Bacillus anthr...	219	Proposed to be essential proteins	Phase 4: April 2009	1VS5	54.3%	Bacillus anthracis

IDP04587 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0118	49183152		50S ribosomal protein L29 [Bacillus anth...	66	Proposed to be essential proteins	Phase 4: April 2009	1R73	45.5%	Bacillus anthracis

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP04582 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0110	49183144		50S ribosomal protein L3 [Bacillus anthr...	210	Proposed to be essential proteins	Phase 4: April 2009	1NKW	53.3%	Bacillus anthracis

IDP04584 (show subtarget assignments)	1	purified	No	BAS0112	49183146		50S ribosomal protein L23 [Bacillus anth...	96	Proposed to be essential proteins	Phase 4: April 2009	1N88	43.8%	Bacillus anthracis

IDP04588 (show subtarget assignments)	1	cloned	No	BAS0130	49183164		preprotein translocase subunit SecY [Bac...	433	Proposed to be essential proteins	Phase 4: April 2009	3DIN	43.8%	Bacillus anthracis

IDP04597 (show subtarget assignments)	1	expressed	No	BAS1384	49184401		resB protein [Bacillus anthracis str. St...	541	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP04613 (show subtarget assignments)	1	cloned	No	BAS3890	49186888		M20/M25/M40 family peptidase [Bacillus a...	376	Proposed to be essential proteins	Phase 4: April 2009	1YSJ	35.6%	Bacillus anthracis

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP04576 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0076	49183111		lysyl-tRNA synthetase [Bacillus anthraci...	499	Proposed to be essential proteins	Phase 4: April 2009	3A74	77.6%	Bacillus anthracis

IDP04578 (show subtarget assignments)	1	cloned	No	BAS0089	49183123		cysteinyl-tRNA synthetase [Bacillus anth...	465	Proposed to be essential proteins	Phase 4: April 2009	1LI5	45.6%	Bacillus anthracis

IDP04574 (show subtarget assignments)	1	soluble	No	BAS0015	49183051		seryl-tRNA synthetase [Bacillus anthraci...	424	Proposed to be essential proteins	Phase 4: April 2009	2DQ3	57.8%	Bacillus anthracis

IDP04573 (show subtarget assignments)	1	crystallized	No	BAS0006	49183045		DNA gyrase subunit A [Bacillus anthracis...	823	Proposed to be essential proteins	Phase 4: April 2009	2XCO	42.9%	Bacillus anthracis

IDP04575 (show subtarget assignments)	1	cloned	No	BAS0037	49183072		methionyl-tRNA synthetase [Bacillus anth...	660	Proposed to be essential proteins	Phase 4: April 2009	4DLP	36.2%	Bacillus anthracis

IDP04579 (show subtarget assignments)	1	cloned	No	BAS0098	49183132		50S ribosomal protein L1 [Bacillus anthr...	230	Proposed to be essential proteins	Phase 4: April 2009	3QOY	56.3%	Bacillus anthracis

IDP04570 (show subtarget assignments)	1	soluble	No	FTT0153	56707323	rplS	50S ribosomal protein L19 [Francisella t...	115	drug target; conserved gene;	Phase 4: April 2009	1VS6	58.3%	Francisella tularensis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04571 (show subtarget assignments)	1	cloned	No	BAS0002	49183041		DNA polymerase III subunit beta [Bacillu...	379	Proposed to be essential proteins	Phase 4: April 2009	2AWA	42%	Bacillus anthracis

IDP04567 (show subtarget assignments)	1	cloned	No	CPF_2099	110800052		putative lipoprotein [Clostridium perfri...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04572 (show subtarget assignments)	1	soluble	No	BAS0005	49183044		DNA gyrase subunit B [Bacillus anthracis...	640	Proposed to be essential proteins	Phase 4: April 2009	1EI1	34.4%	Bacillus anthracis

IDP04580 (show subtarget assignments)	1	cloned	No	BAS0103	49183137		DNA-directed RNA polymerase subunit beta...	1203	Proposed to be essential proteins	Phase 4: April 2009	2GHO	53.6%	Bacillus anthracis

IDP04562 (show subtarget assignments)	1	cloned	No	CPF_1080	110798737		putative lipoprotein [Clostridium perfri...	185	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04560 (show subtarget assignments)	1	in_pdb 3NUA	Yes	CPF_0673	110799762	purC	phosphoribosylaminoimidazole-succinocarb...	235	conserved gene; putative drug target function;	Phase 4: April 2009	3NUA	100%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04555 (show subtarget assignments)	1	cloned	No	STM2272_1_878	16765599	gyrA	DNA gyrase subunit A [Salmonella typhimu...	878	Salmonella essential protein	Phase 4: April 2009	3NUH	57.7%	Salmonella enterica

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP04556 (show subtarget assignments)	1	cloned	No	YPO3008	218930055		putative two-component sensor histidine ...	514	putative drug target function;	Phase 4: April 2009	2C2A	16%	Yersinia pestis	Regulatory functions	Other

IDP04564 (show subtarget assignments)	1	cloned	No	CPF_1610	110800230		putative lipoprotein [Clostridium perfri...	125	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04549 (show subtarget assignments)	1	cloned	No	CPF_0346	110800626		putative lioprotein [Clostridium perfrin...	184	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04581 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0108	49183142		elongation factor Tu [Bacillus anthracis...	395	Proposed to be essential proteins	Phase 4: April 2009	3U2Q	75.4%	Bacillus anthracis

IDP04614 (show subtarget assignments)	1	purified	No	BAS4131	49187128		glycine cleavage system aminomethyltrans...	366	Proposed to be essential proteins	Phase 4: April 2009	1YX2	66.1%	Bacillus anthracis

IDP04679 (show subtarget assignments)	1	expressed	No	GBAA2644	47527936	kinB-2	sporulation kinase B [Bacillus anthracis...	422	putative drug target function;	Phase 4: April 2009	3D36	27.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04530 (show subtarget assignments)	1	soluble	No	STM2519_1_490	16765839	engA	GTP-binding protein EngA [Salmonella typ...	490	Salmonella essential protein	Phase 4: April 2009	2HJG	36.1%	Salmonella enterica

IDP04529 (show subtarget assignments)	1	crystallized	No	STM2481_1_1037	16765801	acrD	aminoglycoside/multidrug efflux system [...	1037	Salmonella essential protein	Phase 4: April 2009	1IWG	66.2%	Salmonella enterica

IDP04532 (show subtarget assignments)	1	cloned	No	STM3301_1_390	16766597	obgE	GTPase ObgE [Salmonella typhimurium LT2]...	390	Salmonella essential protein	Phase 4: April 2009	1LNZ	42.1%	Salmonella enterica

IDP04527 (show subtarget assignments)	1	cloned	No	STM1824_1_454	16765165	pabB	para-aminobenzoate synthase component I ...	454	Salmonella essential protein	Phase 4: April 2009	1K0E	76.2%	Salmonella enterica

IDP04526 (show subtarget assignments)	1	expressed	No	STM1637_1_516	16764981		putative inner membrane protein [Salmone...	516	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04528 (show subtarget assignments)	1	expressed	No	STM2257_1_289	16765585	napH	quinol dehydrogenase membrane component ...	289	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04533 (show subtarget assignments)	1	cloned	No	STM4154_1_1407	16767408	rpoC	DNA-directed RNA polymerase subunit beta...	1407	Salmonella essential protein	Phase 4: April 2009	3IYD	98.6%	Salmonella enterica

IDP04523 (show subtarget assignments)	1	cloned	No	STM0884_1_447	16764245	ulaA	ascorbate-specific PTS system enzyme IIC...	447	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04520 (show subtarget assignments)	1	purified	No	Z0985	15800520		hypothetical protein Z0985 [Escherichia ...	326	Effector protein	Phase 4: April 2009			Escherichia coli

IDP04524 (show subtarget assignments)	1	in_pdb 3Q58	Yes	STM1129_1_226	16764486		N-acetylmannosamine-6-phosphate 2-epimer...	226	Salmonella essential protein	Phase 4: April 2009	3Q58	100%	Salmonella enterica

IDP04518 (show subtarget assignments)	1	cloned	No	CPF_2883	110799727		putative lipoprotein [Clostridium perfri...	361	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04525 (show subtarget assignments)	1	cloned	No	STM1556_1_483	16764900		putative Na+/H+ antiporter [Salmonella t...	483	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04540 (show subtarget assignments)	1	purified	No	CPF_0511	110801291		sensor histidine kinase [Clostridium per...	516	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	18.2%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04513 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2363	110799064		putative thiamin biosynthesis lipoprotei...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1VRM	29.2%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04512 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2342	110798786	modA	molybdate ABC transporter, molybdate-bin...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AMF	33.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP04509 (show subtarget assignments)	1	selected	No	CPF_0440	110800446		iron compound ABC transporter, iron comp...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PT1	37.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04515 (show subtarget assignments)	1	expressed	No	CPF_2673	110799735		putative sensor histidine kinase [Clostr...	583	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13.9%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP04505 (show subtarget assignments)	1	soluble	No	VCA0531	15601291		sensor histidine kinase [Vibrio cholerae...	497	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.9%	Vibrio cholerae	Regulatory functions	Other

IDP04507 (show subtarget assignments)	1	crystallized	No	VCA1079	9658525		pyridoxamine 5`-phosphate oxidase [Vibri...	211	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1G76	65.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04503 (show subtarget assignments)	1	cloned	No	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04502 (show subtarget assignments)	1	purified	No	VC1136	9655608		amidotransferase HisH [Vibrio cholerae O...	203	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KA9	36.9%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04504 (show subtarget assignments)	1	cloned	No	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04497 (show subtarget assignments)	1	soluble	No	VC0768	9655215		GMP synthase [Vibrio cholerae O1 biovar ...	517	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	80.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04496 (show subtarget assignments)	1	expressed	No	VC0675	15640694	thyA	thymidylate synthase [Vibrio cholerae O1...	283	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3V8H	35.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04498 (show subtarget assignments)	1	purified	No	VC0791	15640810		sensor kinase citA [Vibrio cholerae O1 b...	565	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2J80	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP04494 (show subtarget assignments)	1	expressed	No	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04493 (show subtarget assignments)	1	cloned	No	YPO4089	115349677		pyridoxal-phosphate dependent enzyme [Ye...	320	putative drug target function;	Phase 4: April 2009	3HMK	36.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04495 (show subtarget assignments)	1	soluble	No	VC0622	15640642		sensory box sensor histidine kinase/resp...	1177	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP04499 (show subtarget assignments)	1	cloned	No	VC0869	15640885		phosphoribosylformylglycinamidine syntha...	1297	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	73.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04490 (show subtarget assignments)	1	in_pdb 3MJF	No	YPO3729	218930734	purD	phosphoribosylamine--glycine ligase [Yer...	428	conserved gene; putative drug target function;	Phase 4: April 2009	3MJF	100%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04491 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3765	218930769	pepQ	proline dipeptidase [Yersinia pestis CO9...	443	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RVA	54.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04487 (show subtarget assignments)	1	expressed	No	YPO3598	115349219		putative membrane protein [Yersinia pest...	255	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3U66	17.3%	Yersinia pestis	Cell envelope	Other

IDP04486 (show subtarget assignments)	1	cloned	No	YPO3597	115349218		conserved hypothetical protein [Yersinia...	448	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04488 (show subtarget assignments)	1	expressed	No	YPO3685	115349305	yhcQ	putative HlyD family secretion protein [...	311	conserved gene; putative drug target function;	Phase 4: April 2009	2F1M	17%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04601
(show subtarget assignments)

1

in_pdb
3RHI

Yes

BAS3574

49186575

DNA-binding protein HU [Bacillus anthrac...

90

Proposed to be essential proteins

Phase 4: April 2009

3RHI

100%

Bacillus anthracis

IDP04603
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3670

49186669

prolyl-tRNA synthetase [Bacillus anthrac...

566

Proposed to be essential proteins

Phase 4: April 2009

2J3L

58.1%

Bacillus anthracis

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04604
(show subtarget assignments)

1

cloned

No

BAS3678

49186677

30S ribosomal protein S2 [Bacillus anthr...

233

Proposed to be essential proteins

Phase 4: April 2009

1FJG

56.2%

Bacillus anthracis

IDP04612
(show subtarget assignments)

1

cloned

No

BAS3764

49186763

phospho-N-acetylmuramoyl-pentapeptide-tr...

324

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP04593
(show subtarget assignments)

1

cloned

No

BAS0144

49183178

30S ribosomal protein S9 [Bacillus anthr...

130

Proposed to be essential proteins

Phase 4: April 2009

1VS5

55.4%

Bacillus anthracis

IDP04592
(show subtarget assignments)

1

expressed

No

BAS0143

49183177

50S ribosomal protein L13 [Bacillus anth...

145

Proposed to be essential proteins

Phase 4: April 2009

1P85

56.6%

Bacillus anthracis

IDP04595
(show subtarget assignments)

1

soluble

No

BAS0565

49183590

nicotinate phosphoribosyltransferase [Ba...

487

Proposed to be essential proteins

Phase 4: April 2009

2F7F

61.4%

Bacillus anthracis

IDP04590
(show subtarget assignments)

1

expressed

No

BAS0136

49183170

30S ribosomal protein S11 [Bacillus anth...

129

Proposed to be essential proteins

Phase 4: April 2009

1VS5

65.9%

Bacillus anthracis

IDP04589
(show subtarget assignments)

1

expressed

No

BAS0135

49183169

30S ribosomal protein S13 [Bacillus anth...

121

Proposed to be essential proteins

Phase 4: April 2009

1FJG

63.9%

Bacillus anthracis

IDP04591
(show subtarget assignments)

1

cloned

No

BAS0138

49183172

50S ribosomal protein L17 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1NKW

50.8%

Bacillus anthracis

IDP04596
(show subtarget assignments)

1

in_crystallization_trials

No

BAS1099

49184119

tryptophanyl-tRNA synthetase [Bacillus a...

329

Proposed to be essential proteins

Phase 4: April 2009

3PRH

73.9%

Bacillus anthracis

IDP04586
(show subtarget assignments)

1

cloned

No

BAS0117

49183151

50S ribosomal protein L16 [Bacillus anth...

144

Proposed to be essential proteins

Phase 4: April 2009

1VSA

60.4%

Bacillus anthracis

IDP04585
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0116

49183150

30S ribosomal protein S3 [Bacillus anthr...

219

Proposed to be essential proteins

Phase 4: April 2009

1VS5

54.3%

Bacillus anthracis

IDP04587
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0118

49183152

50S ribosomal protein L29 [Bacillus anth...

66

Proposed to be essential proteins

Phase 4: April 2009

1R73

45.5%

Bacillus anthracis

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP04582
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0110

49183144

50S ribosomal protein L3 [Bacillus anthr...

210

Proposed to be essential proteins

Phase 4: April 2009

1NKW

53.3%

Bacillus anthracis

IDP04584
(show subtarget assignments)

1

purified

No

BAS0112

49183146

50S ribosomal protein L23 [Bacillus anth...

96

Proposed to be essential proteins

Phase 4: April 2009

1N88

43.8%

Bacillus anthracis

IDP04588
(show subtarget assignments)

1

cloned

No

BAS0130

49183164

preprotein translocase subunit SecY [Bac...

433

Proposed to be essential proteins

Phase 4: April 2009

3DIN

43.8%

Bacillus anthracis

IDP04597
(show subtarget assignments)

1

expressed

No

BAS1384

49184401

resB protein [Bacillus anthracis str. St...

541

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP04613
(show subtarget assignments)

1

cloned

No

BAS3890

49186888

M20/M25/M40 family peptidase [Bacillus a...

376

Proposed to be essential proteins

Phase 4: April 2009

1YSJ

35.6%

Bacillus anthracis

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP04576
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0076

49183111

lysyl-tRNA synthetase [Bacillus anthraci...

499

Proposed to be essential proteins

Phase 4: April 2009

3A74

77.6%

Bacillus anthracis

IDP04578
(show subtarget assignments)

1

cloned

No

BAS0089

49183123

cysteinyl-tRNA synthetase [Bacillus anth...

465

Proposed to be essential proteins

Phase 4: April 2009

1LI5

45.6%

Bacillus anthracis

IDP04574
(show subtarget assignments)

1

soluble

No

BAS0015

49183051

seryl-tRNA synthetase [Bacillus anthraci...

424

Proposed to be essential proteins

Phase 4: April 2009

2DQ3

57.8%

Bacillus anthracis

IDP04573
(show subtarget assignments)

1

crystallized

No

BAS0006

49183045

DNA gyrase subunit A [Bacillus anthracis...

823

Proposed to be essential proteins

Phase 4: April 2009

2XCO

42.9%

Bacillus anthracis

IDP04575
(show subtarget assignments)

1

cloned

No

BAS0037

49183072

methionyl-tRNA synthetase [Bacillus anth...

660

Proposed to be essential proteins

Phase 4: April 2009

4DLP

36.2%

Bacillus anthracis

IDP04579
(show subtarget assignments)

1

cloned

No

BAS0098

49183132

50S ribosomal protein L1 [Bacillus anthr...

230

Proposed to be essential proteins

Phase 4: April 2009

3QOY

56.3%

Bacillus anthracis

IDP04570
(show subtarget assignments)

1

soluble

No

FTT0153

56707323

rplS

50S ribosomal protein L19 [Francisella t...

115

drug target; conserved gene;

Phase 4: April 2009

1VS6

58.3%

Francisella tularensis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04571
(show subtarget assignments)

1

cloned

No

BAS0002

49183041

DNA polymerase III subunit beta [Bacillu...

379

Proposed to be essential proteins

Phase 4: April 2009

2AWA

42%

Bacillus anthracis

IDP04567
(show subtarget assignments)

1

cloned

No

CPF_2099

110800052

putative lipoprotein [Clostridium perfri...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04572
(show subtarget assignments)

1

soluble

No

BAS0005

49183044

DNA gyrase subunit B [Bacillus anthracis...

640

Proposed to be essential proteins

Phase 4: April 2009

1EI1

34.4%

Bacillus anthracis

IDP04580
(show subtarget assignments)

1

cloned

No

BAS0103

49183137

DNA-directed RNA polymerase subunit beta...

1203

Proposed to be essential proteins

Phase 4: April 2009

2GHO

53.6%

Bacillus anthracis

IDP04562
(show subtarget assignments)

1

cloned

No

CPF_1080

110798737

putative lipoprotein [Clostridium perfri...

185

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04560
(show subtarget assignments)

1

in_pdb
3NUA

Yes

CPF_0673

110799762

purC

phosphoribosylaminoimidazole-succinocarb...

235

conserved gene; putative drug target function;

Phase 4: April 2009

3NUA

100%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04555
(show subtarget assignments)

1

cloned

No

STM2272_1_878

16765599

gyrA

DNA gyrase subunit A [Salmonella typhimu...

878

Salmonella essential protein

Phase 4: April 2009

3NUH

57.7%

Salmonella enterica

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP04556
(show subtarget assignments)

1

cloned

No

YPO3008

218930055

putative two-component sensor histidine ...

514

putative drug target function;

Phase 4: April 2009

2C2A

16%

Yersinia pestis

Regulatory functions

Other

IDP04564
(show subtarget assignments)

1

cloned

No

CPF_1610

110800230

putative lipoprotein [Clostridium perfri...

125

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04549
(show subtarget assignments)

1

cloned

No

CPF_0346

110800626

putative lioprotein [Clostridium perfrin...

184

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04581
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0108

49183142

elongation factor Tu [Bacillus anthracis...

395

Proposed to be essential proteins

Phase 4: April 2009

3U2Q

75.4%

Bacillus anthracis

IDP04614
(show subtarget assignments)

1

purified

No

BAS4131

49187128

glycine cleavage system aminomethyltrans...

366

Proposed to be essential proteins

Phase 4: April 2009

1YX2

66.1%

Bacillus anthracis

IDP04679
(show subtarget assignments)

1

expressed

No

GBAA2644

47527936

kinB-2

sporulation kinase B [Bacillus anthracis...

422

putative drug target function;

Phase 4: April 2009

3D36

27.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04530
(show subtarget assignments)

1

soluble

No

STM2519_1_490

16765839

engA

GTP-binding protein EngA [Salmonella typ...

490

Salmonella essential protein

Phase 4: April 2009

2HJG

36.1%

Salmonella enterica

IDP04529
(show subtarget assignments)

1

crystallized

No

STM2481_1_1037

16765801

acrD

aminoglycoside/multidrug efflux system [...

1037

Salmonella essential protein

Phase 4: April 2009

1IWG

66.2%

Salmonella enterica

IDP04532
(show subtarget assignments)

1

cloned

No

STM3301_1_390

16766597

obgE

GTPase ObgE [Salmonella typhimurium LT2]...

390

Salmonella essential protein

Phase 4: April 2009

1LNZ

42.1%

Salmonella enterica

IDP04527
(show subtarget assignments)

1

cloned

No

STM1824_1_454

16765165

pabB

para-aminobenzoate synthase component I ...

454

Salmonella essential protein

Phase 4: April 2009

1K0E

76.2%

Salmonella enterica

IDP04526
(show subtarget assignments)

1

expressed

No

STM1637_1_516

16764981

putative inner membrane protein [Salmone...

516

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04528
(show subtarget assignments)

1

expressed

No

STM2257_1_289

16765585

napH

quinol dehydrogenase membrane component ...

289

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04533
(show subtarget assignments)

1

cloned

No

STM4154_1_1407

16767408

rpoC

DNA-directed RNA polymerase subunit beta...

1407

Salmonella essential protein

Phase 4: April 2009

3IYD

98.6%

Salmonella enterica

IDP04523
(show subtarget assignments)

1

cloned

No

STM0884_1_447

16764245

ulaA

ascorbate-specific PTS system enzyme IIC...

447

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04520
(show subtarget assignments)

1

purified

No

Z0985

15800520

hypothetical protein Z0985 [Escherichia ...

326

Effector protein

Phase 4: April 2009

Escherichia coli

IDP04524
(show subtarget assignments)

1

in_pdb
3Q58

Yes

STM1129_1_226

16764486

N-acetylmannosamine-6-phosphate 2-epimer...

226

Salmonella essential protein

Phase 4: April 2009

3Q58

100%

Salmonella enterica

IDP04518
(show subtarget assignments)

1

cloned

No

CPF_2883

110799727

putative lipoprotein [Clostridium perfri...

361

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04525
(show subtarget assignments)

1

cloned

No

STM1556_1_483

16764900

putative Na+/H+ antiporter [Salmonella t...

483

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04540
(show subtarget assignments)

1

purified

No

CPF_0511

110801291

sensor histidine kinase [Clostridium per...

516

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

18.2%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04513
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2363

110799064

putative thiamin biosynthesis lipoprotei...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1VRM

29.2%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04512
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2342

110798786

modA

molybdate ABC transporter, molybdate-bin...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AMF

33.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP04509
(show subtarget assignments)

1

selected

No

CPF_0440

110800446

iron compound ABC transporter, iron comp...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PT1

37.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04515
(show subtarget assignments)

1

expressed

No

CPF_2673

110799735

putative sensor histidine kinase [Clostr...

583

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13.9%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP04505
(show subtarget assignments)

1

soluble

No

VCA0531

15601291

sensor histidine kinase [Vibrio cholerae...

497

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.9%

Vibrio cholerae

Regulatory functions

Other

IDP04507
(show subtarget assignments)

1

crystallized

No

VCA1079

9658525

pyridoxamine 5`-phosphate oxidase [Vibri...

211

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1G76

65.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04503
(show subtarget assignments)

1

cloned

No

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04502
(show subtarget assignments)

1

purified

No

VC1136

9655608

amidotransferase HisH [Vibrio cholerae O...

203

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KA9

36.9%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04504
(show subtarget assignments)

1

cloned

No

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04497
(show subtarget assignments)

1

soluble

No

VC0768

9655215

GMP synthase [Vibrio cholerae O1 biovar ...

517

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

80.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04496
(show subtarget assignments)

1

expressed

No

VC0675

15640694

thyA

thymidylate synthase [Vibrio cholerae O1...

283

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3V8H

35.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04498
(show subtarget assignments)

1

purified

No

VC0791

15640810

sensor kinase citA [Vibrio cholerae O1 b...

565

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2J80

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP04494
(show subtarget assignments)

1

expressed

No

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04493
(show subtarget assignments)

1

cloned

No

YPO4089

115349677

pyridoxal-phosphate dependent enzyme [Ye...

320

putative drug target function;

Phase 4: April 2009

3HMK

36.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04495
(show subtarget assignments)

1

soluble

No

VC0622

15640642

sensory box sensor histidine kinase/resp...

1177

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP04499
(show subtarget assignments)

1

cloned

No

VC0869

15640885

phosphoribosylformylglycinamidine syntha...

1297

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

73.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04490
(show subtarget assignments)

1

in_pdb
3MJF

No

YPO3729

218930734

purD

phosphoribosylamine--glycine ligase [Yer...

428

conserved gene; putative drug target function;

Phase 4: April 2009

3MJF

100%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04491
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3765

218930769

pepQ

proline dipeptidase [Yersinia pestis CO9...

443

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RVA

54.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04487
(show subtarget assignments)

1

expressed

No

YPO3598

115349219

putative membrane protein [Yersinia pest...

255

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3U66

17.3%

Yersinia pestis

Cell envelope

Other

IDP04486
(show subtarget assignments)

1

cloned

No

YPO3597

115349218

conserved hypothetical protein [Yersinia...

448

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04488
(show subtarget assignments)

1

expressed

No

YPO3685

115349305

yhcQ

putative HlyD family secretion protein [...

311

conserved gene; putative drug target function;

Phase 4: April 2009

2F1M

17%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

Targets