Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00059 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4013	30258522		fibronectin/fibrinogen-binding protein, ...	569	Virulence	Phase 1: October 2007	3DOA	22.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP90581 (show subtarget assignments)	8	soluble	No	Cj0543	15791904	proS	prolyl-tRNA synthetase [Campylobacter je...	569	Predicted Essential	Community Requests	2J3L	42.8%	Campylobacter jejuni

IDP05650 (show subtarget assignments)	1	soluble	No	Cj0543	6968007	proS	hypothetical protein Cj0539 [Campylobact...	569	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	42.8%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP00833 (show subtarget assignments)	1	cloned	No	SACOL2627	57286532	betA	choline dehydrogenase	569	Conserved Gene / Pathway	Phase 2: March 2008	3LJP	32.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP90275 (show subtarget assignments)	8	soluble	No	TGME49_030450	211965620		GMP synthase, putative [Toxoplasma gondi...	569	Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...	Community Requests	1GPM	51%	Toxoplasma gondii

IDP02817 (show subtarget assignments)	1	cloned	No	lmo2185	16804224		hypothetical protein lmo2185 [Listeria m...	569	Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...	Phase 3: June 2008	2O6P	8.4%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP05230 (show subtarget assignments)	1	soluble	No	lmo1319	16803359	proS	prolyl-tRNA synthetase [Listeria monocyt...	568	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	63%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05180 (show subtarget assignments)	1	soluble	No	BA_3644	30258169		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TCF	29.6%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05599 (show subtarget assignments)	1	purified	No	BA_3642	30258168		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP02404 (show subtarget assignments)	1	cloned	No	GBAA2730	47528021		neutral protease [Bacillus anthracis str...	567	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	25.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90830 (show subtarget assignments)	8	expressed	No	YPO2527	16122746	menD	2-succinyl-6-hydroxy-2,4-cyclohexadiene-...	567	Predicted Essential	Community Requests	2JLA	69%	Yersinia pestis

IDP05337 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1282	57651833	proS	prolyl-tRNA synthetase [Staphylococcus a...	567	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	55.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP02384 (show subtarget assignments)	1	expressed	No	GBAA3202	47528494	hscC	chaperone protein hscC [Bacillus anthrac...	566	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V7Y	38%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP91679 (show subtarget assignments)	8	selected	No	HHV8GK18_gp64	139472850	vIRF-3	vIRF-3 [Human herpesvirus 8]	566	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests			Human herpesvirus

IDP04603 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3670	49186669		prolyl-tRNA synthetase [Bacillus anthrac...	566	Proposed to be essential proteins	Phase 4: April 2009	2J3L	58.1%	Bacillus anthracis

IDP02401 (show subtarget assignments)	1	cloned	No	Cj0574	15791934	ilvI	acetolactate synthase 3 catalytic subuni...	566	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1JSC	40.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP90382 (show subtarget assignments)	8	expressed	No	CT_350	3328771		hypothetical protein [Chlamydia trachoma...	566	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05550 (show subtarget assignments)	1	expressed	No	lmo0481	16802524	-	hypothetical protein lmo0481 [Listeria m...	566	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91640 (show subtarget assignments)	8	cloned	No	NP_216900	15609521		bifunctional salicyl-AMP ligase/salicyl-...	565	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1MD9	42.1%	Mycobacterium tuberculosis

IDP04498 (show subtarget assignments)	1	purified	No	VC0791	15640810		sensor kinase citA [Vibrio cholerae O1 b...	565	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2J80	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP02702 (show subtarget assignments)	1	cloned	No	GBAA3442	47528726		neutral protease [Bacillus anthracis str...	565	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	24.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01133 (show subtarget assignments)	1	in_pdb 3SKS	Yes	BA_1353	30255290		oligoendopeptidase F, putative	564	Drug Target Function	Phase 2: March 2008	3SKS	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91899 (show subtarget assignments)	8	selected	No	SpneCM_010100002520	298254473		ABC transporter, ATP-binding/permease pr...	564	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	39.1%	Streptococcus pneumoniae

IDP05719 (show subtarget assignments)	1	soluble	No	BA_1903	30256563		peptidase, M23/M37 family [Bacillus anth...	564	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3SLU	15.2%	Bacillus anthracis	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP02787 (show subtarget assignments)	1	cloned	No	FTT0697	56707817	ftsI	penicillin binding protein (peptidoglyca...	564	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3OC2	37.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02335 (show subtarget assignments)	1	expressed	No	GBAA2583	47527873		hypothetical protein GBAA2583 [Bacillus ...	563	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3SKS	26.3%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04154 (show subtarget assignments)	1	cloned	No	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP92098 (show subtarget assignments)	8	selected	No	TGME49_090670	211966125		cytosol aminopeptidase [Toxoplasma gondi...	563	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3KQX	41.2%	Toxoplasma gondii

IDP90191 (show subtarget assignments)	8	expressed	No	AAM13632.1	20153171	CPXV193 CDS	CPXV193 protein	563	kelch-like protein	Community Requests	3II7	13%	Cowpox virus	conserved hypothetical proteins	0

IDP91443 (show subtarget assignments)	8	cloned	No	VV1_0417	27363885		putative chitinase [Vibrio vulnificus CM...	563	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3CQL	15.5%	Vibrio vulnificus

IDP00506 (show subtarget assignments)	1	expressed	No	YPO2491	16122712		putative hemolysin activator protein	562	Conserved Gene / Pathway	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05141 (show subtarget assignments)	1	cloned	No	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP00472 (show subtarget assignments)	1	expressed	No	YPO0598	16120927		putative hemolysin activator protein	562	Virulence Associated Factor	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90959 (show subtarget assignments)	8	cloned	No	PP2258	81441302		Sensory box protein	562	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	2R6O	20.6%	Pseudomonas putida

IDP05436 (show subtarget assignments)	1	soluble	No	lmo2085	16804124	-	peptidoglycan binding protein [Listeria ...	562	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IRP	7.1%	Listeria monocytogenes	Regulatory functions: Other

IDP01792 (show subtarget assignments)	1	expressed	No	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP05600 (show subtarget assignments)	1	soluble	No	BA_3645	30258170		putative oligopeptide ABC transporter, o...	562	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90137 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_179	68449250		ankyrin-like protein [Monkeypox virus]	561	similar to VACV-COP-B4R, MPXV-ZAI96-B5R	Community Requests	1N11	11.2%	Monkeypox virus

IDP02241 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1129c	56708206		hypothetical protein FTT1129c [Francisel...	561	Drug Target	Phase 3: June 2008	1O5Z	11.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP00431 (show subtarget assignments)	1	selected	No	YPO3720	16123858	shlB	hemolysin activator protein	561	Virulence Associated Factor	Phase 2: March 2008	2QDZ	25%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP92059 (show subtarget assignments)	8	selected	No	TGME49_061950	237832039		ATP synthase beta chain, putative [Toxop...	560	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2W6E	69.3%	Toxoplasma gondii

IDP00832 (show subtarget assignments)	1	in_pdb 3IB3 3III	No	SACOL2612	57286517		hydrolase, CocE/NonD family	560	Drug Target Function	Phase 2: March 2008	3IB3	100%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01981 (show subtarget assignments)	1	soluble	No	STM1969	16765307	fliF	flagellar MS-ring protein [Salmonella ty...	560	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP90323 (show subtarget assignments)	8	cloned	No	CT082	15604801		hypothetical protein CT082 [Chlamydia tr...	560	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP01667 (show subtarget assignments)	1	expressed	No	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	Phase 3: June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP00150 (show subtarget assignments)	1	purified	No	VC0402	15640429	mshL	MSHA biogenesis protein MshL	559	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP02820 (show subtarget assignments)	1	purified	No	lmo2196	16804235		hypothetical protein lmo2196 [Listeria m...	558	Known virulence-Intracellular Survival; PMID:11083832	Phase 3: June 2008	1B05	30.1%	Listeria monocytogenes	Cellular processes	DNA transformation

IDP90193 (show subtarget assignments)	8	cloned	No	AAM13637.1	20153176	CPXV198 CDS	CPXV198 protein	558	ankyrin-like protein	Community Requests	1N11	11.1%	Cowpox virus	conserved hypothetical proteins	0

IDP91578 (show subtarget assignments)	8	cloned	No	BAB37984	13364036	ECs4561	translocated intimin receptor Tir [Esche...	558	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2ZQK	12.2%	Escherichia coli

IDP05644 (show subtarget assignments)	1	cloned	No	CD3230	126700850	bclA2	exosporium glycoprotein [Clostridium dif...	558	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.3%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP01132 (show subtarget assignments)	1	soluble	No	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02470 (show subtarget assignments)	1	purified	No	lmo0865	16802906		hypothetical protein lmo0865 [Listeria m...	557	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	1TUO	26.2%	Listeria monocytogenes	Energy metabolism	Sugars

IDP05723 (show subtarget assignments)	1	expressed	No	BA_3001	30257589		alkaline phosphatase [Bacillus anthracis...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A52	25.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP90201 (show subtarget assignments)	8	cloned	No	AAM13653.1	20153192	CPXV215 CDS	CPXV215 Protein	557	kelch-like protein	Community Requests	2VPJ	12.2%	Cowpox virus	conserved hypothetical proteins	0

IDP02460 (show subtarget assignments)	1	cloned	No	YPO1675	16121939	cheD	methyl-accepting chemotaxis protein [Yer...	557	CD; Drug target functions	Phase 3: June 2008	3ZX6	43.3%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP05112 (show subtarget assignments)	1	cloned	No	CD2246	126699864	cspC	putative germination-specific protease [...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3EIF	22.3%	Clostridium difficile	Unknown function: General

IDP05453 (show subtarget assignments)	1	in_crystallization_trials	No	BAS5213	49188199	-	arginyl-tRNA synthetase [Bacillus anthra...	556	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.8%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05197 (show subtarget assignments)	1	cloned	No	CD1131	126698725		putative solute-binding lipoprotein [Clo...	556	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3RQT	19.8%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP05027 (show subtarget assignments)	1	purified	No	BA_0231	30253731		putative oligopeptide ABC transporter, o...	555	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	27.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05215 (show subtarget assignments)	1	cloned	No	CD3091	126700708	treA	trehalose-6-phosphate hydrolase [Clostri...	555	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1UOK	50.2%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05277 (show subtarget assignments)	1	expressed	No	YPO2630	16122843	glnS	glutaminyl-tRNA synthetase [Yersinia pes...	598	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1O0B	80.3%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP04501 (show subtarget assignments)	1	cloned	No	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP05184 (show subtarget assignments)	1	purified	No	BA_5305	30259782		conserved domain protein [Bacillus anthr...	554	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP01710 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA0371	47525642		glycosyl hydrolase family protein [Bacil...	554	Conserved; Drug target functions	Phase 3: June 2008	2ZE0	67%	Bacillus anthracis	Energy metabolism	Sugars

IDP91533 (show subtarget assignments)	8	selected	No	TC_0727	7190756	omcB	OmcB [Chlamydia muridarum Nigg]	554	vaccine candidate / Vaccine formulation	Community Requests			Chlamydia muridarum

IDP05058 (show subtarget assignments)	1	in_crystallization_trials	No	CD0468	126698044	malL	oligo-1,6-glucosidase [Clostridium diffi...	554	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2ZE0	44%	Clostridium difficile	Energy metabolism: Sugars

IDP01089 (show subtarget assignments)	1	soluble	No	STM4533	16767777	tsr	methyl-accepting chemotaxis protein I	553	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	49.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP90209 (show subtarget assignments)	8	expressed	No	MYXV_gp144	9633776	m140R	m140R	553	kelch motif, similar to VACV-Cop:A55R	Community Requests	1U6D	14.3%	Myxoma virus	unknown, conserved protein	0

IDP05505 (show subtarget assignments)	1	cloned	No	CD1029	126698613		putative cell wall anchored protein [Clo...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Regulatory functions: Other

IDP05255 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90415 (show subtarget assignments)	8	cloned	No	CT_443	3328874	omcB	60kDa Cysteine-Rich OMP [Chlamydia trach...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00953 (show subtarget assignments)	1	in_crystallization_trials	No	STM1183	16764539	flgK	flagellar hook-associated protein FlgK	553	Conserved Gene / Pathway	Phase 2: March 2008	2D4Y	83.5%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP05566 (show subtarget assignments)	1	soluble	No	lmo2569	16804607	-	hypothetical protein lmo2569 [Listeria m...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3O9P	26.7%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Plasmid functions

IDP05387 (show subtarget assignments)	1	purified	No	BA_2041	30256692		putative oligopeptide ABC transporter, o...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01883 (show subtarget assignments)	1	expressed	No	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP90347 (show subtarget assignments)	8	soluble	No	CT205	15604925	pfkA_1	diphosphate--fructose-6-phosphate 1-phos...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KZH	36.9%	Chlamydia trachomatis

IDP01308 (show subtarget assignments)	1	expressed	No	VC1516	15641524		iron-sulfur cluster-binding protein	553	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Energy metabolism	Electron transport

IDP00070 (show subtarget assignments)	0	work_stopped	No	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP92051 (show subtarget assignments)	8	selected	No	TGME49_051620	237836211		flap endonuclease-1, putative [Toxoplasm...	552	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1UL1	31%	Toxoplasma gondii

IDP01977 (show subtarget assignments)	1	cloned	No	Cj1444c	15792762	kpsD	capsular polysaccharide ABC transporter,...	552	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP04095 (show subtarget assignments)	1	expressed	No	YPO1987	115347708		hypothetical protein [Yersinia pestis CO...	552	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02390 (show subtarget assignments)	1	cloned	No	CBU_1718	29542276	groEL	chaperonin, 60 kDa [Coxiella burnetii RS...	552	Conserved; Drug target functions	Phase 3: June 2008	2EU1	75.5%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02507 (show subtarget assignments)	1	cloned	No	FTT1298	56708357	ubiB	2-polyprenylphenol 6-hydroxylase [Franci...	552	Conserved; Drug target functions	Phase 3: June 2008			Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP92133 (show subtarget assignments)	8	selected	No	TGME49_033110	211965834		inosine-5'-monophosphate dehydrogenase, ...	551	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1JCN	53.6%	Toxoplasma gondii

IDP91075 (show subtarget assignments)	8	cloned	No	jhp0343	15611411	msbA	multi-drug resistance protein [Helicobac...	551	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	31.4%	Helicobacter pylori

IDP91720 (show subtarget assignments)	8	selected	No	NP_068810	223468676	RELA	transcription factor p65 isoform 1 [Homo...	551	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1NFI	54.4%	Homo sapiens

IDP91330 (show subtarget assignments)	8	soluble	No	VV2_0263	27366712		ABC transporter ATPase [Vibrio vulnificu...	551	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91699 (show subtarget assignments)	8	selected	No	NP_002750	4506103	EIF2AK2	interferon-induced, double-stranded RNA-...	551	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A19	50.6%	Homo sapiens

IDP05038 (show subtarget assignments)	1	expressed	No	BA_1902	30256562		multicopper oxidase family protein [Baci...	551	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3T6V	25.8%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP91737 (show subtarget assignments)	8	selected	No	Q5WMC9_ECOLX	0			550	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1F02	11.1%	Escherichia coli

IDP01329 (show subtarget assignments)	1	in_pdb 3HJB	No	VC0374	15640401	pgi	glucose-6-phosphate isomerase	550	Drug Target Function	Phase 2: March 2008	3HJB	99.8%	Vibrio cholerae	Energy metabolism	Glycolysis/gluconeogenesis

IDP01001 (show subtarget assignments)	1	soluble	No	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP05350 (show subtarget assignments)	1	cloned	No	CD3192	126700811		cell surface protein [Clostridium diffic...	550	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP01236 (show subtarget assignments)	1	expressed	No	BA_5514	30259974		glycosyl transferase, group 1 family pro...	550	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02125 (show subtarget assignments)	1	cloned	No	STM4453	16767699	treC	trehalose-6-phosphate hydrolase [Salmone...	550	Conserved; Drug target functions	Phase 3: June 2008	1UOK	44.7%	Salmonella enterica	Energy metabolism	Other

IDP04349 (show subtarget assignments)	1	expressed	No	STM0557_1_550	16763935		putative inner membrane protein [Salmone...	550	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05455 (show subtarget assignments)	1	soluble	No	BA_0223	30253724		conserved hypothetical protein [Bacillus...	549	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP91611 (show subtarget assignments)	8	expressed	No	BAB37278	13363327	ECs3855	putative enterotoxin [Escherichia coli O...	549	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP01862 (show subtarget assignments)	1	soluble	No	GBAA5510	47530828	tagH	teichoic acids export protein ATP-bindin...	549	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1F3O	12.4%	Bacillus anthracis	Transport and binding proteins	Other

IDP00059
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4013

30258522

fibronectin/fibrinogen-binding protein, ...

569

Virulence

Phase 1: October 2007

3DOA

22.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP90581
(show subtarget assignments)

8

soluble

No

Cj0543

15791904

proS

prolyl-tRNA synthetase [Campylobacter je...

569

Predicted Essential

Community Requests

2J3L

42.8%

Campylobacter jejuni

IDP05650
(show subtarget assignments)

1

soluble

No

Cj0543

6968007

proS

hypothetical protein Cj0539 [Campylobact...

569

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

42.8%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP00833
(show subtarget assignments)

1

cloned

No

SACOL2627

57286532

betA

choline dehydrogenase

569

Conserved Gene / Pathway

Phase 2: March 2008

3LJP

32.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP90275
(show subtarget assignments)

8

soluble

No

TGME49_030450

211965620

GMP synthase, putative [Toxoplasma gondi...

569

Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...

Community Requests

1GPM

51%

Toxoplasma gondii

IDP02817
(show subtarget assignments)

1

cloned

No

lmo2185

16804224

hypothetical protein lmo2185 [Listeria m...

569

Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...

Phase 3: June 2008

2O6P

8.4%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP05230
(show subtarget assignments)

1

soluble

No

lmo1319

16803359

proS

prolyl-tRNA synthetase [Listeria monocyt...

568

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

63%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05180
(show subtarget assignments)

1

soluble

No

BA_3644

30258169

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TCF

29.6%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05599
(show subtarget assignments)

1

purified

No

BA_3642

30258168

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP02404
(show subtarget assignments)

1

cloned

No

GBAA2730

47528021

neutral protease [Bacillus anthracis str...

567

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

25.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90830
(show subtarget assignments)

8

expressed

No

YPO2527

16122746

menD

2-succinyl-6-hydroxy-2,4-cyclohexadiene-...

567

Predicted Essential

Community Requests

2JLA

69%

Yersinia pestis

IDP05337
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1282

57651833

proS

prolyl-tRNA synthetase [Staphylococcus a...

567

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

55.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP02384
(show subtarget assignments)

1

expressed

No

GBAA3202

47528494

hscC

chaperone protein hscC [Bacillus anthrac...

566

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V7Y

38%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP91679
(show subtarget assignments)

8

selected

No

HHV8GK18_gp64

139472850

vIRF-3

vIRF-3 [Human herpesvirus 8]

566

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

Human herpesvirus

IDP04603
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3670

49186669

prolyl-tRNA synthetase [Bacillus anthrac...

566

Proposed to be essential proteins

Phase 4: April 2009

2J3L

58.1%

Bacillus anthracis

IDP02401
(show subtarget assignments)

1

cloned

No

Cj0574

15791934

ilvI

acetolactate synthase 3 catalytic subuni...

566

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1JSC

40.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP90382
(show subtarget assignments)

8

expressed

No

CT_350

3328771

hypothetical protein [Chlamydia trachoma...

566

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05550
(show subtarget assignments)

1

expressed

No

lmo0481

16802524

-

hypothetical protein lmo0481 [Listeria m...

566

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91640
(show subtarget assignments)

8

cloned

No

NP_216900

15609521

bifunctional salicyl-AMP ligase/salicyl-...

565

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1MD9

42.1%

Mycobacterium tuberculosis

IDP04498
(show subtarget assignments)

1

purified

No

VC0791

15640810

sensor kinase citA [Vibrio cholerae O1 b...

565

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2J80

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP02702
(show subtarget assignments)

1

cloned

No

GBAA3442

47528726

neutral protease [Bacillus anthracis str...

565

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

24.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01133
(show subtarget assignments)

1

in_pdb
3SKS

Yes

BA_1353

30255290

oligoendopeptidase F, putative

564

Drug Target Function

Phase 2: March 2008

3SKS

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91899
(show subtarget assignments)

8

selected

No

SpneCM_010100002520

298254473

ABC transporter, ATP-binding/permease pr...

564

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

39.1%

Streptococcus pneumoniae

IDP05719
(show subtarget assignments)

1

soluble

No

BA_1903

30256563

peptidase, M23/M37 family [Bacillus anth...

564

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3SLU

15.2%

Bacillus anthracis

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP02787
(show subtarget assignments)

1

cloned

No

FTT0697

56707817

ftsI

penicillin binding protein (peptidoglyca...

564

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3OC2

37.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02335
(show subtarget assignments)

1

expressed

No

GBAA2583

47527873

hypothetical protein GBAA2583 [Bacillus ...

563

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3SKS

26.3%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04154
(show subtarget assignments)

1

cloned

No

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP92098
(show subtarget assignments)

8

selected

No

TGME49_090670

211966125

cytosol aminopeptidase [Toxoplasma gondi...

563

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3KQX

41.2%

Toxoplasma gondii

IDP90191
(show subtarget assignments)

8

expressed

No

AAM13632.1

20153171

CPXV193 CDS

CPXV193 protein

563

kelch-like protein

Community Requests

3II7

13%

Cowpox virus

conserved hypothetical proteins

0

IDP91443
(show subtarget assignments)

8

cloned

No

VV1_0417

27363885

putative chitinase [Vibrio vulnificus CM...

563

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3CQL

15.5%

Vibrio vulnificus

IDP00506
(show subtarget assignments)

1

expressed

No

YPO2491

16122712

putative hemolysin activator protein

562

Conserved Gene / Pathway

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05141
(show subtarget assignments)

1

cloned

No

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP00472
(show subtarget assignments)

1

expressed

No

YPO0598

16120927

putative hemolysin activator protein

562

Virulence Associated Factor

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90959
(show subtarget assignments)

8

cloned

No

PP2258

81441302

Sensory box protein

562

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

2R6O

20.6%

Pseudomonas putida

IDP05436
(show subtarget assignments)

1

soluble

No

lmo2085

16804124

-

peptidoglycan binding protein [Listeria ...

562

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IRP

7.1%

Listeria monocytogenes

Regulatory functions: Other

IDP01792
(show subtarget assignments)

1

expressed

No

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP05600
(show subtarget assignments)

1

soluble

No

BA_3645

30258170

putative oligopeptide ABC transporter, o...

562

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90137
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_179

68449250

ankyrin-like protein [Monkeypox virus]

561

similar to VACV-COP-B4R, MPXV-ZAI96-B5R

Community Requests

1N11

11.2%

Monkeypox virus

IDP02241
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1129c

56708206

hypothetical protein FTT1129c [Francisel...

561

Drug Target

Phase 3: June 2008

1O5Z

11.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP00431
(show subtarget assignments)

1

selected

No

YPO3720

16123858

shlB

hemolysin activator protein

561

Virulence Associated Factor

Phase 2: March 2008

2QDZ

25%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP92059
(show subtarget assignments)

8

selected

No

TGME49_061950

237832039

ATP synthase beta chain, putative [Toxop...

560

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2W6E

69.3%

Toxoplasma gondii

IDP00832
(show subtarget assignments)

1

in_pdb
3IB3
3III

No

SACOL2612

57286517

hydrolase, CocE/NonD family

560

Drug Target Function

Phase 2: March 2008

3IB3

100%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01981
(show subtarget assignments)

1

soluble

No

STM1969

16765307

fliF

flagellar MS-ring protein [Salmonella ty...

560

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP90323
(show subtarget assignments)

8

cloned

No

CT082

15604801

hypothetical protein CT082 [Chlamydia tr...

560

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP01667
(show subtarget assignments)

1

expressed

No

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

Phase 3: June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP00150
(show subtarget assignments)

1

purified

No

VC0402

15640429

mshL

MSHA biogenesis protein MshL

559

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02820
(show subtarget assignments)

1

purified

No

lmo2196

16804235

hypothetical protein lmo2196 [Listeria m...

558

Known virulence-Intracellular Survival; PMID:11083832

Phase 3: June 2008

1B05

30.1%

Listeria monocytogenes

Cellular processes

DNA transformation

IDP90193
(show subtarget assignments)

8

cloned

No

AAM13637.1

20153176

CPXV198 CDS

CPXV198 protein

558

ankyrin-like protein

Community Requests

1N11

11.1%

Cowpox virus

conserved hypothetical proteins

0

IDP91578
(show subtarget assignments)

8

cloned

No

BAB37984

13364036

ECs4561

translocated intimin receptor Tir [Esche...

558

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2ZQK

12.2%

Escherichia coli

IDP05644
(show subtarget assignments)

1

cloned

No

CD3230

126700850

bclA2

exosporium glycoprotein [Clostridium dif...

558

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.3%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP01132
(show subtarget assignments)

1

soluble

No

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02470
(show subtarget assignments)

1

purified

No

lmo0865

16802906

hypothetical protein lmo0865 [Listeria m...

557

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

1TUO

26.2%

Listeria monocytogenes

Energy metabolism

Sugars

IDP05723
(show subtarget assignments)

1

expressed

No

BA_3001

30257589

alkaline phosphatase [Bacillus anthracis...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A52

25.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP90201
(show subtarget assignments)

8

cloned

No

AAM13653.1

20153192

CPXV215 CDS

CPXV215 Protein

557

kelch-like protein

Community Requests

2VPJ

12.2%

Cowpox virus

conserved hypothetical proteins

0

IDP02460
(show subtarget assignments)

1

cloned

No

YPO1675

16121939

cheD

methyl-accepting chemotaxis protein [Yer...

557

CD; Drug target functions

Phase 3: June 2008

3ZX6

43.3%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP05112
(show subtarget assignments)

1

cloned

No

CD2246

126699864

cspC

putative germination-specific protease [...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3EIF

22.3%

Clostridium difficile

Unknown function: General

IDP05453
(show subtarget assignments)

1

in_crystallization_trials

No

BAS5213

49188199

-

arginyl-tRNA synthetase [Bacillus anthra...

556

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.8%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05197
(show subtarget assignments)

1

cloned

No

CD1131

126698725

putative solute-binding lipoprotein [Clo...

556

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3RQT

19.8%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP05027
(show subtarget assignments)

1

purified

No

BA_0231

30253731

putative oligopeptide ABC transporter, o...

555

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

27.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05215
(show subtarget assignments)

1

cloned

No

CD3091

126700708

treA

trehalose-6-phosphate hydrolase [Clostri...

555

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1UOK

50.2%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05277
(show subtarget assignments)

1

expressed

No

YPO2630

16122843

glnS

glutaminyl-tRNA synthetase [Yersinia pes...

598

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1O0B

80.3%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP04501
(show subtarget assignments)

1

cloned

No

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP05184
(show subtarget assignments)

1

purified

No

BA_5305

30259782

conserved domain protein [Bacillus anthr...

554

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP01710
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA0371

47525642

glycosyl hydrolase family protein [Bacil...

554

Conserved; Drug target functions

Phase 3: June 2008

2ZE0

67%

Bacillus anthracis

Energy metabolism

Sugars

IDP91533
(show subtarget assignments)

8

selected

No

TC_0727

7190756

omcB

OmcB [Chlamydia muridarum Nigg]

554

vaccine candidate / Vaccine formulation

Community Requests

Chlamydia muridarum

IDP05058
(show subtarget assignments)

1

in_crystallization_trials

No

CD0468

126698044

malL

oligo-1,6-glucosidase [Clostridium diffi...

554

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2ZE0

44%

Clostridium difficile

Energy metabolism: Sugars

IDP01089
(show subtarget assignments)

1

soluble

No

STM4533

16767777

tsr

methyl-accepting chemotaxis protein I

553

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

49.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP90209
(show subtarget assignments)

8

expressed

No

MYXV_gp144

9633776

m140R

553

kelch motif, similar to VACV-Cop:A55R

Community Requests

1U6D

14.3%

Myxoma virus

unknown, conserved protein

0

IDP05505
(show subtarget assignments)

1

cloned

No

CD1029

126698613

putative cell wall anchored protein [Clo...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Regulatory functions: Other

IDP05255
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90415
(show subtarget assignments)

8

cloned

No

CT_443

3328874

omcB

60kDa Cysteine-Rich OMP [Chlamydia trach...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00953
(show subtarget assignments)

1

in_crystallization_trials

No

STM1183

16764539

flgK

flagellar hook-associated protein FlgK

553

Conserved Gene / Pathway

Phase 2: March 2008

2D4Y

83.5%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP05566
(show subtarget assignments)

1

soluble

No

lmo2569

16804607

-

hypothetical protein lmo2569 [Listeria m...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3O9P

26.7%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Plasmid functions

IDP05387
(show subtarget assignments)

1

purified

No

BA_2041

30256692

putative oligopeptide ABC transporter, o...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01883
(show subtarget assignments)

1

expressed

No

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP90347
(show subtarget assignments)

8

soluble

No

CT205

15604925

pfkA_1

diphosphate--fructose-6-phosphate 1-phos...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KZH

36.9%

Chlamydia trachomatis

IDP01308
(show subtarget assignments)

1

expressed

No

VC1516

15641524

iron-sulfur cluster-binding protein

553

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Energy metabolism

Electron transport

IDP00070
(show subtarget assignments)

0

work_stopped

No

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP92051
(show subtarget assignments)

8

selected

No

TGME49_051620

237836211

flap endonuclease-1, putative [Toxoplasm...

552

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1UL1

31%

Toxoplasma gondii

IDP01977
(show subtarget assignments)

1

cloned

No

Cj1444c

15792762

kpsD

capsular polysaccharide ABC transporter,...

552

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP04095
(show subtarget assignments)

1

expressed

No

YPO1987

115347708

hypothetical protein [Yersinia pestis CO...

552

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP02390
(show subtarget assignments)

1

cloned

No

CBU_1718

29542276

groEL

chaperonin, 60 kDa [Coxiella burnetii RS...

552

Conserved; Drug target functions

Phase 3: June 2008

2EU1

75.5%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02507
(show subtarget assignments)

1

cloned

No

FTT1298

56708357

ubiB

2-polyprenylphenol 6-hydroxylase [Franci...

552

Conserved; Drug target functions

Phase 3: June 2008

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP92133
(show subtarget assignments)

8

selected

No

TGME49_033110

211965834

inosine-5'-monophosphate dehydrogenase, ...

551

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1JCN

53.6%

Toxoplasma gondii

IDP91075
(show subtarget assignments)

8

cloned

No

jhp0343

15611411

msbA

multi-drug resistance protein [Helicobac...

551

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

31.4%

Helicobacter pylori

IDP91720
(show subtarget assignments)

8

selected

No

NP_068810

223468676

RELA

transcription factor p65 isoform 1 [Homo...

551

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1NFI

54.4%

Homo sapiens

IDP91330
(show subtarget assignments)

8

soluble

No

VV2_0263

27366712

ABC transporter ATPase [Vibrio vulnificu...

551

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91699
(show subtarget assignments)

8

selected

No

NP_002750

4506103

EIF2AK2

interferon-induced, double-stranded RNA-...

551

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A19

50.6%

Homo sapiens

IDP05038
(show subtarget assignments)

1

expressed

No

BA_1902

30256562

multicopper oxidase family protein [Baci...

551

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3T6V

25.8%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP91737
(show subtarget assignments)

8

selected

No

Q5WMC9_ECOLX

0

550

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1F02

11.1%

Escherichia coli

IDP01329
(show subtarget assignments)

1

in_pdb
3HJB

No

VC0374

15640401

pgi

glucose-6-phosphate isomerase

550

Drug Target Function

Phase 2: March 2008

3HJB

99.8%

Vibrio cholerae

Energy metabolism

Glycolysis/gluconeogenesis

IDP01001
(show subtarget assignments)

1

soluble

No

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP05350
(show subtarget assignments)

1

cloned

No

CD3192

126700811

cell surface protein [Clostridium diffic...

550

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP01236
(show subtarget assignments)

1

expressed

No

BA_5514

30259974

glycosyl transferase, group 1 family pro...

550

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02125
(show subtarget assignments)

1

cloned

No

STM4453

16767699

treC

trehalose-6-phosphate hydrolase [Salmone...

550

Conserved; Drug target functions

Phase 3: June 2008

1UOK

44.7%

Salmonella enterica

Energy metabolism

Other

IDP04349
(show subtarget assignments)

1

expressed

No

STM0557_1_550

16763935

putative inner membrane protein [Salmone...

550

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05455
(show subtarget assignments)

1

soluble

No

BA_0223

30253724

conserved hypothetical protein [Bacillus...

549

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP91611
(show subtarget assignments)

8

expressed

No

BAB37278

13363327

ECs3855

putative enterotoxin [Escherichia coli O...

549

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP01862
(show subtarget assignments)

1

soluble

No

GBAA5510

47530828

tagH

teichoic acids export protein ATP-bindin...

549

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1F3O

12.4%

Bacillus anthracis

Transport and binding proteins

Other