Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04451 (show subtarget assignments)	1	cloned	No	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Community Interest	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP04453 (show subtarget assignments)	1	cloned	No	YPO1055	115346834	fabZ	(3R)-hydroxymyristoyl-(acyl carrier prot...	181	conserved gene; putative drug target function;	Phase 4: April 2009	1U1Z	44.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04459 (show subtarget assignments)	1	cloned	No	YPO1472	115347226		conserved hypothetical protein [Yersinia...	782	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	40.7%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04463 (show subtarget assignments)	1	cloned	No	YPO1959	115347684	narR	nitrate/nitrite sensor protein [Yersinia...	593	conserved gene; putative drug target function;	Phase 4: April 2009	3EZH	8.4%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04468 (show subtarget assignments)	1	cloned	No	YPO2205	115347912	trpC	tryptophan biosynthesis protein TrpCF [Y...	475	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PII	69.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04470 (show subtarget assignments)	1	cloned	No	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04476 (show subtarget assignments)	1	cloned	No	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04481 (show subtarget assignments)	1	cloned	No	YPO3204	115348844	nmpB	phosphate regulon sensor protein PhoR [Y...	438	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Yersinia pestis	Regulatory functions	Other

IDP04486 (show subtarget assignments)	1	cloned	No	YPO3597	115349218		conserved hypothetical protein [Yersinia...	448	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04492 (show subtarget assignments)	1	cloned	No	YPO3834	218930837	pldA	phospholipase A [Yersinia pestis CO92]	292	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1FW2	69.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP04493 (show subtarget assignments)	1	cloned	No	YPO4089	115349677		pyridoxal-phosphate dependent enzyme [Ye...	320	putative drug target function;	Phase 4: April 2009	3HMK	36.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04499 (show subtarget assignments)	1	cloned	No	VC0869	15640885		phosphoribosylformylglycinamidine syntha...	1297	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	73.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04501 (show subtarget assignments)	1	cloned	No	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04503 (show subtarget assignments)	1	cloned	No	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04504 (show subtarget assignments)	1	cloned	No	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP04518 (show subtarget assignments)	1	cloned	No	CPF_2883	110799727		putative lipoprotein [Clostridium perfri...	361	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04523 (show subtarget assignments)	1	cloned	No	STM0884_1_447	16764245	ulaA	ascorbate-specific PTS system enzyme IIC...	447	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04525 (show subtarget assignments)	1	cloned	No	STM1556_1_483	16764900		putative Na+/H+ antiporter [Salmonella t...	483	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04527 (show subtarget assignments)	1	cloned	No	STM1824_1_454	16765165	pabB	para-aminobenzoate synthase component I ...	454	Salmonella essential protein	Phase 4: April 2009	1K0E	76.2%	Salmonella enterica

IDP04532 (show subtarget assignments)	1	cloned	No	STM3301_1_390	16766597	obgE	GTPase ObgE [Salmonella typhimurium LT2]...	390	Salmonella essential protein	Phase 4: April 2009	1LNZ	42.1%	Salmonella enterica

IDP04533 (show subtarget assignments)	1	cloned	No	STM4154_1_1407	16767408	rpoC	DNA-directed RNA polymerase subunit beta...	1407	Salmonella essential protein	Phase 4: April 2009	3IYD	98.6%	Salmonella enterica

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04544 (show subtarget assignments)	1	cloned	No	VC2713	9657310		osmolarity sensor protein EnvZ [Vibrio c...	438	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	16.7%	Vibrio cholerae	Regulatory functions	Other

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04549 (show subtarget assignments)	1	cloned	No	CPF_0346	110800626		putative lioprotein [Clostridium perfrin...	184	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP04555 (show subtarget assignments)	1	cloned	No	STM2272_1_878	16765599	gyrA	DNA gyrase subunit A [Salmonella typhimu...	878	Salmonella essential protein	Phase 4: April 2009	3NUH	57.7%	Salmonella enterica

IDP04556 (show subtarget assignments)	1	cloned	No	YPO3008	218930055		putative two-component sensor histidine ...	514	putative drug target function;	Phase 4: April 2009	2C2A	16%	Yersinia pestis	Regulatory functions	Other

IDP04562 (show subtarget assignments)	1	cloned	No	CPF_1080	110798737		putative lipoprotein [Clostridium perfri...	185	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04564 (show subtarget assignments)	1	cloned	No	CPF_1610	110800230		putative lipoprotein [Clostridium perfri...	125	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04567 (show subtarget assignments)	1	cloned	No	CPF_2099	110800052		putative lipoprotein [Clostridium perfri...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04571 (show subtarget assignments)	1	cloned	No	BAS0002	49183041		DNA polymerase III subunit beta [Bacillu...	379	Proposed to be essential proteins	Phase 4: April 2009	2AWA	42%	Bacillus anthracis

IDP04575 (show subtarget assignments)	1	cloned	No	BAS0037	49183072		methionyl-tRNA synthetase [Bacillus anth...	660	Proposed to be essential proteins	Phase 4: April 2009	4DLP	36.2%	Bacillus anthracis

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP04578 (show subtarget assignments)	1	cloned	No	BAS0089	49183123		cysteinyl-tRNA synthetase [Bacillus anth...	465	Proposed to be essential proteins	Phase 4: April 2009	1LI5	45.6%	Bacillus anthracis

IDP04579 (show subtarget assignments)	1	cloned	No	BAS0098	49183132		50S ribosomal protein L1 [Bacillus anthr...	230	Proposed to be essential proteins	Phase 4: April 2009	3QOY	56.3%	Bacillus anthracis

IDP04580 (show subtarget assignments)	1	cloned	No	BAS0103	49183137		DNA-directed RNA polymerase subunit beta...	1203	Proposed to be essential proteins	Phase 4: April 2009	2GHO	53.6%	Bacillus anthracis

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP04586 (show subtarget assignments)	1	cloned	No	BAS0117	49183151		50S ribosomal protein L16 [Bacillus anth...	144	Proposed to be essential proteins	Phase 4: April 2009	1VSA	60.4%	Bacillus anthracis

IDP04588 (show subtarget assignments)	1	cloned	No	BAS0130	49183164		preprotein translocase subunit SecY [Bac...	433	Proposed to be essential proteins	Phase 4: April 2009	3DIN	43.8%	Bacillus anthracis

IDP04591 (show subtarget assignments)	1	cloned	No	BAS0138	49183172		50S ribosomal protein L17 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1NKW	50.8%	Bacillus anthracis

IDP04593 (show subtarget assignments)	1	cloned	No	BAS0144	49183178		30S ribosomal protein S9 [Bacillus anthr...	130	Proposed to be essential proteins	Phase 4: April 2009	1VS5	55.4%	Bacillus anthracis

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04604 (show subtarget assignments)	1	cloned	No	BAS3678	49186677		30S ribosomal protein S2 [Bacillus anthr...	233	Proposed to be essential proteins	Phase 4: April 2009	1FJG	56.2%	Bacillus anthracis

IDP04606 (show subtarget assignments)	1	cloned	No	BAS3692	49186691		tRNA (guanine-N(1)-)-methyltransferase [...	244	Proposed to be essential proteins	Phase 4: April 2009	3KY7	62.3%	Bacillus anthracis

IDP04607 (show subtarget assignments)	1	cloned	No	BAS3700	49186699		ribonuclease III [Bacillus anthracis str...	245	Proposed to be essential proteins	Phase 4: April 2009	1O0W	40%	Bacillus anthracis

IDP04611 (show subtarget assignments)	1	cloned	No	BAS3754	49186753		sporulation sigma factor SigG [Bacillus ...	289	Proposed to be essential proteins	Phase 4: April 2009	1L0O	37%	Bacillus anthracis

IDP04612 (show subtarget assignments)	1	cloned	No	BAS3764	49186763		phospho-N-acetylmuramoyl-pentapeptide-tr...	324	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP04613 (show subtarget assignments)	1	cloned	No	BAS3890	49186888		M20/M25/M40 family peptidase [Bacillus a...	376	Proposed to be essential proteins	Phase 4: April 2009	1YSJ	35.6%	Bacillus anthracis

IDP04615 (show subtarget assignments)	1	cloned	No	BAS4297	49187293		aspartyl-tRNA synthetase [Bacillus anthr...	591	Proposed to be essential proteins	Phase 4: April 2009	1EQR	52.7%	Bacillus anthracis

IDP04618 (show subtarget assignments)	1	cloned	No	BAS4456	49187451		phenylalanyl-tRNA synthetase subunit alp...	344	Proposed to be essential proteins	Phase 4: April 2009	2RHQ	57.6%	Bacillus anthracis

IDP04620 (show subtarget assignments)	1	cloned	No	BAS4482	49187477		DNA polymerase I [Bacillus anthracis str...	891	Proposed to be essential proteins	Phase 4: April 2009	3TAN	45%	Bacillus anthracis

IDP04621 (show subtarget assignments)	1	cloned	No	BAS4494	49187489		acetyl-CoA carboxylase carboxyltransfera...	324	Proposed to be essential proteins	Phase 4: April 2009	2F9I	60.2%	Bacillus anthracis

IDP04625 (show subtarget assignments)	1	cloned	No	BAS5050	49188036		glycosyl transferase, group 4 family pro...	357	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP04626 (show subtarget assignments)	1	cloned	No	BAS5178	49188164		peptide chain release factor 1 [Bacillus...	358	Proposed to be essential proteins	Phase 4: April 2009	1ZBT	59.2%	Bacillus anthracis

IDP04627 (show subtarget assignments)	8	cloned	No	BAS5321	49188305		replicative DNA helicase [Bacillus anthr...	453	Proposed to be essential proteins	Community Requests	2VYE	75.3%	Bacillus anthracis

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP04631 (show subtarget assignments)	1	cloned	No	CBU_1891	215919282	pilQ	type II and III secretion system family ...	353	conserved gene;	Phase 4: April 2009			Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP04637 (show subtarget assignments)	1	cloned	No	FTT0371c	56707522	folC	FolC bifunctional protein [Francisella t...	393	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1W78	29.8%	Francisella tularensis

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04662 (show subtarget assignments)	1	cloned	No	GBAA0650	47525929		sensor histidine kinase [Bacillus anthra...	463	putative drug target function;	Phase 4: April 2009	2C2A	17.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04663 (show subtarget assignments)	1	cloned	No	BAS5325	49188309		30S ribosomal protein S18 [Bacillus anth...	77	Proposed to be essential proteins	Phase 4: April 2009	1P6G	50.6%	Bacillus anthracis

IDP04667 (show subtarget assignments)	1	cloned	No	GBAA1313	47526578		sensor histidine kinase [Bacillus anthra...	466	putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04668 (show subtarget assignments)	1	cloned	No	GBAA1327	47526592		phaP protein [Bacillus anthracis str. 'A...	174	conserved gene; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04678 (show subtarget assignments)	1	cloned	No	GBAA2560	47527849		sensor histidine kinase [Bacillus anthra...	385	putative drug target function;	Phase 4: April 2009	3DGE	20.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04682 (show subtarget assignments)	1	cloned	No	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP04693 (show subtarget assignments)	1	cloned	No	GBAA5598	47530920		sensor histidine kinase [Bacillus anthra...	376	drug target; putative drug target function;	Phase 4: April 2009	3GIG	26.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04696 (show subtarget assignments)	1	cloned	No	YPCD1.15c	5832437	YPCD1.15c	hypothetical protein YPCD1.15c [Yersinia...	152	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP04698 (show subtarget assignments)	1	cloned	No	YPCD1.46	16082734	yscT	needle complex export protein [Yersinia ...	261	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04700 (show subtarget assignments)	1	cloned	No	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04702 (show subtarget assignments)	1	cloned	No	YPO0272	218927479		putative type III secretion apparatus pr...	264	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04704 (show subtarget assignments)	1	cloned	No	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04705 (show subtarget assignments)	1	cloned	No	YPO0499	115346308		hypothetical protein [Yersinia pestis CO...	337	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04707 (show subtarget assignments)	1	cloned	No	BAS0113	49183147		50S ribosomal protein L2 [Bacillus anthr...	276	Proposed to be essential proteins	Phase 4: April 2009	1VSA	65%	Bacillus anthracis

IDP04709 (show subtarget assignments)	1	cloned	No	YPO0501	115346310		conserved hypothetical protein [Yersinia...	503	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04712 (show subtarget assignments)	1	cloned	No	YPO0514	115346324		putative OmpA-family membrane protein [Y...	536	virulence factor; putative drug target function;	Phase 4: April 2009	2L26	9%	Yersinia pestis	Cell envelope	Other

IDP04451
(show subtarget assignments)

1

cloned

No

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Community Interest

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair

IDP04453
(show subtarget assignments)

1

cloned

No

YPO1055

115346834

fabZ

(3R)-hydroxymyristoyl-(acyl carrier prot...

181

conserved gene; putative drug target function;

Phase 4: April 2009

1U1Z

44.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04459
(show subtarget assignments)

1

cloned

No

YPO1472

115347226

conserved hypothetical protein [Yersinia...

782

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

40.7%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04463
(show subtarget assignments)

1

cloned

No

YPO1959

115347684

narR

nitrate/nitrite sensor protein [Yersinia...

593

conserved gene; putative drug target function;

Phase 4: April 2009

3EZH

8.4%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04468
(show subtarget assignments)

1

cloned

No

YPO2205

115347912

trpC

tryptophan biosynthesis protein TrpCF [Y...

475

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PII

69.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04470
(show subtarget assignments)

1

cloned

No

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04476
(show subtarget assignments)

1

cloned

No

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04481
(show subtarget assignments)

1

cloned

No

YPO3204

115348844

nmpB

phosphate regulon sensor protein PhoR [Y...

438

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Yersinia pestis

Regulatory functions

Other

IDP04486
(show subtarget assignments)

1

cloned

No

YPO3597

115349218

conserved hypothetical protein [Yersinia...

448

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04492
(show subtarget assignments)

1

cloned

No

YPO3834

218930837

pldA

phospholipase A [Yersinia pestis CO92]

292

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1FW2

69.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP04493
(show subtarget assignments)

1

cloned

No

YPO4089

115349677

pyridoxal-phosphate dependent enzyme [Ye...

320

putative drug target function;

Phase 4: April 2009

3HMK

36.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04499
(show subtarget assignments)

1

cloned

No

VC0869

15640885

phosphoribosylformylglycinamidine syntha...

1297

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

73.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04501
(show subtarget assignments)

1

cloned

No

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04503
(show subtarget assignments)

1

cloned

No

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04504
(show subtarget assignments)

1

cloned

No

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP04518
(show subtarget assignments)

1

cloned

No

CPF_2883

110799727

putative lipoprotein [Clostridium perfri...

361

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04523
(show subtarget assignments)

1

cloned

No

STM0884_1_447

16764245

ulaA

ascorbate-specific PTS system enzyme IIC...

447

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04525
(show subtarget assignments)

1

cloned

No

STM1556_1_483

16764900

putative Na+/H+ antiporter [Salmonella t...

483

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04527
(show subtarget assignments)

1

cloned

No

STM1824_1_454

16765165

pabB

para-aminobenzoate synthase component I ...

454

Salmonella essential protein

Phase 4: April 2009

1K0E

76.2%

Salmonella enterica

IDP04532
(show subtarget assignments)

1

cloned

No

STM3301_1_390

16766597

obgE

GTPase ObgE [Salmonella typhimurium LT2]...

390

Salmonella essential protein

Phase 4: April 2009

1LNZ

42.1%

Salmonella enterica

IDP04533
(show subtarget assignments)

1

cloned

No

STM4154_1_1407

16767408

rpoC

DNA-directed RNA polymerase subunit beta...

1407

Salmonella essential protein

Phase 4: April 2009

3IYD

98.6%

Salmonella enterica

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04544
(show subtarget assignments)

1

cloned

No

VC2713

9657310

osmolarity sensor protein EnvZ [Vibrio c...

438

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

16.7%

Vibrio cholerae

Regulatory functions

Other

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04549
(show subtarget assignments)

1

cloned

No

CPF_0346

110800626

putative lioprotein [Clostridium perfrin...

184

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP04555
(show subtarget assignments)

1

cloned

No

STM2272_1_878

16765599

gyrA

DNA gyrase subunit A [Salmonella typhimu...

878

Salmonella essential protein

Phase 4: April 2009

3NUH

57.7%

Salmonella enterica

IDP04556
(show subtarget assignments)

1

cloned

No

YPO3008

218930055

putative two-component sensor histidine ...

514

putative drug target function;

Phase 4: April 2009

2C2A

16%

Yersinia pestis

Regulatory functions

Other

IDP04562
(show subtarget assignments)

1

cloned

No

CPF_1080

110798737

putative lipoprotein [Clostridium perfri...

185

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04564
(show subtarget assignments)

1

cloned

No

CPF_1610

110800230

putative lipoprotein [Clostridium perfri...

125

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04567
(show subtarget assignments)

1

cloned

No

CPF_2099

110800052

putative lipoprotein [Clostridium perfri...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04571
(show subtarget assignments)

1

cloned

No

BAS0002

49183041

DNA polymerase III subunit beta [Bacillu...

379

Proposed to be essential proteins

Phase 4: April 2009

2AWA

42%

Bacillus anthracis

IDP04575
(show subtarget assignments)

1

cloned

No

BAS0037

49183072

methionyl-tRNA synthetase [Bacillus anth...

660

Proposed to be essential proteins

Phase 4: April 2009

4DLP

36.2%

Bacillus anthracis

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP04578
(show subtarget assignments)

1

cloned

No

BAS0089

49183123

cysteinyl-tRNA synthetase [Bacillus anth...

465

Proposed to be essential proteins

Phase 4: April 2009

1LI5

45.6%

Bacillus anthracis

IDP04579
(show subtarget assignments)

1

cloned

No

BAS0098

49183132

50S ribosomal protein L1 [Bacillus anthr...

230

Proposed to be essential proteins

Phase 4: April 2009

3QOY

56.3%

Bacillus anthracis

IDP04580
(show subtarget assignments)

1

cloned

No

BAS0103

49183137

DNA-directed RNA polymerase subunit beta...

1203

Proposed to be essential proteins

Phase 4: April 2009

2GHO

53.6%

Bacillus anthracis

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP04586
(show subtarget assignments)

1

cloned

No

BAS0117

49183151

50S ribosomal protein L16 [Bacillus anth...

144

Proposed to be essential proteins

Phase 4: April 2009

1VSA

60.4%

Bacillus anthracis

IDP04588
(show subtarget assignments)

1

cloned

No

BAS0130

49183164

preprotein translocase subunit SecY [Bac...

433

Proposed to be essential proteins

Phase 4: April 2009

3DIN

43.8%

Bacillus anthracis

IDP04591
(show subtarget assignments)

1

cloned

No

BAS0138

49183172

50S ribosomal protein L17 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1NKW

50.8%

Bacillus anthracis

IDP04593
(show subtarget assignments)

1

cloned

No

BAS0144

49183178

30S ribosomal protein S9 [Bacillus anthr...

130

Proposed to be essential proteins

Phase 4: April 2009

1VS5

55.4%

Bacillus anthracis

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04604
(show subtarget assignments)

1

cloned

No

BAS3678

49186677

30S ribosomal protein S2 [Bacillus anthr...

233

Proposed to be essential proteins

Phase 4: April 2009

1FJG

56.2%

Bacillus anthracis

IDP04606
(show subtarget assignments)

1

cloned

No

BAS3692

49186691

tRNA (guanine-N(1)-)-methyltransferase [...

244

Proposed to be essential proteins

Phase 4: April 2009

3KY7

62.3%

Bacillus anthracis

IDP04607
(show subtarget assignments)

1

cloned

No

BAS3700

49186699

ribonuclease III [Bacillus anthracis str...

245

Proposed to be essential proteins

Phase 4: April 2009

1O0W

40%

Bacillus anthracis

IDP04611
(show subtarget assignments)

1

cloned

No

BAS3754

49186753

sporulation sigma factor SigG [Bacillus ...

289

Proposed to be essential proteins

Phase 4: April 2009

1L0O

37%

Bacillus anthracis

IDP04612
(show subtarget assignments)

1

cloned

No

BAS3764

49186763

phospho-N-acetylmuramoyl-pentapeptide-tr...

324

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP04613
(show subtarget assignments)

1

cloned

No

BAS3890

49186888

M20/M25/M40 family peptidase [Bacillus a...

376

Proposed to be essential proteins

Phase 4: April 2009

1YSJ

35.6%

Bacillus anthracis

IDP04615
(show subtarget assignments)

1

cloned

No

BAS4297

49187293

aspartyl-tRNA synthetase [Bacillus anthr...

591

Proposed to be essential proteins

Phase 4: April 2009

1EQR

52.7%

Bacillus anthracis

IDP04618
(show subtarget assignments)

1

cloned

No

BAS4456

49187451

phenylalanyl-tRNA synthetase subunit alp...

344

Proposed to be essential proteins

Phase 4: April 2009

2RHQ

57.6%

Bacillus anthracis

IDP04620
(show subtarget assignments)

1

cloned

No

BAS4482

49187477

DNA polymerase I [Bacillus anthracis str...

891

Proposed to be essential proteins

Phase 4: April 2009

3TAN

45%

Bacillus anthracis

IDP04621
(show subtarget assignments)

1

cloned

No

BAS4494

49187489

acetyl-CoA carboxylase carboxyltransfera...

324

Proposed to be essential proteins

Phase 4: April 2009

2F9I

60.2%

Bacillus anthracis

IDP04625
(show subtarget assignments)

1

cloned

No

BAS5050

49188036

glycosyl transferase, group 4 family pro...

357

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP04626
(show subtarget assignments)

1

cloned

No

BAS5178

49188164

peptide chain release factor 1 [Bacillus...

358

Proposed to be essential proteins

Phase 4: April 2009

1ZBT

59.2%

Bacillus anthracis

IDP04627
(show subtarget assignments)

8

cloned

No

BAS5321

49188305

replicative DNA helicase [Bacillus anthr...

453

Proposed to be essential proteins

Community Requests

2VYE

75.3%

Bacillus anthracis

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP04631
(show subtarget assignments)

1

cloned

No

CBU_1891

215919282

pilQ

type II and III secretion system family ...

353

conserved gene;

Phase 4: April 2009

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP04637
(show subtarget assignments)

1

cloned

No

FTT0371c

56707522

folC

FolC bifunctional protein [Francisella t...

393

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1W78

29.8%

Francisella tularensis

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04662
(show subtarget assignments)

1

cloned

No

GBAA0650

47525929

sensor histidine kinase [Bacillus anthra...

463

putative drug target function;

Phase 4: April 2009

2C2A

17.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04663
(show subtarget assignments)

1

cloned

No

BAS5325

49188309

30S ribosomal protein S18 [Bacillus anth...

77

Proposed to be essential proteins

Phase 4: April 2009

1P6G

50.6%

Bacillus anthracis

IDP04667
(show subtarget assignments)

1

cloned

No

GBAA1313

47526578

sensor histidine kinase [Bacillus anthra...

466

putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04668
(show subtarget assignments)

1

cloned

No

GBAA1327

47526592

phaP protein [Bacillus anthracis str. 'A...

174

conserved gene; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04678
(show subtarget assignments)

1

cloned

No

GBAA2560

47527849

sensor histidine kinase [Bacillus anthra...

385

putative drug target function;

Phase 4: April 2009

3DGE

20.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04682
(show subtarget assignments)

1

cloned

No

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP04693
(show subtarget assignments)

1

cloned

No

GBAA5598

47530920

sensor histidine kinase [Bacillus anthra...

376

drug target; putative drug target function;

Phase 4: April 2009

3GIG

26.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04696
(show subtarget assignments)

1

cloned

No

YPCD1.15c

5832437

YPCD1.15c

hypothetical protein YPCD1.15c [Yersinia...

152

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP04698
(show subtarget assignments)

1

cloned

No

YPCD1.46

16082734

yscT

needle complex export protein [Yersinia ...

261

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04700
(show subtarget assignments)

1

cloned

No

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04702
(show subtarget assignments)

1

cloned

No

YPO0272

218927479

putative type III secretion apparatus pr...

264

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04704
(show subtarget assignments)

1

cloned

No

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04705
(show subtarget assignments)

1

cloned

No

YPO0499

115346308

hypothetical protein [Yersinia pestis CO...

337

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04707
(show subtarget assignments)

1

cloned

No

BAS0113

49183147

50S ribosomal protein L2 [Bacillus anthr...

276

Proposed to be essential proteins

Phase 4: April 2009

1VSA

65%

Bacillus anthracis

IDP04709
(show subtarget assignments)

1

cloned

No

YPO0501

115346310

conserved hypothetical protein [Yersinia...

503

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04712
(show subtarget assignments)

1

cloned

No

YPO0514

115346324

putative OmpA-family membrane protein [Y...

536

virulence factor; putative drug target function;

Phase 4: April 2009

2L26

9%

Yersinia pestis

Cell envelope

Other

Targets