Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90110 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_015	68449089		ankyrin-like protein [Monkeypox virus]	660	similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L	Community Requests	1N0Q	4.4%	Monkeypox virus

IDP90216 (show subtarget assignments)	8	expressed	No	MYXV_gp008	9633799	m005L	m005L, m5, M-T5	483	ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.	Community Requests	1N0R	8.5%	Myxoma virus	host range factor, host defense modulator	0

IDP90193 (show subtarget assignments)	8	cloned	No	AAM13637.1	20153176	CPXV198 CDS	CPXV198 protein	558	ankyrin-like protein	Community Requests	1N11	11.1%	Cowpox virus	conserved hypothetical proteins	0

IDP90184 (show subtarget assignments)	8	expressed	No	AAM13486.1	20153025	CPXV039 CDS	CPXV039 protein	473	ankyrin repeat protein	Community Requests	1N11	14.4%	Cowpox virus	conserved hypothetical proteins	0

IDP90207 (show subtarget assignments)	8	soluble	No	MYXV_gp152	9633784	m149R	m149R	490	ankyrin motif, similar to VACV-Cop:B4R	Community Requests	1N11	14.9%	Myxoma virus	host range factor	0

IDP90137 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_179	68449250		ankyrin-like protein [Monkeypox virus]	561	similar to VACV-COP-B4R, MPXV-ZAI96-B5R	Community Requests	1N11	11.2%	Monkeypox virus

IDP90178 (show subtarget assignments)	8	purified	No	AAM13472.1	20153011	VHR1	VHR1 or CPXV025 protein	668	ankyrin-like protein, CP77	Community Requests	1N11	10%	Cowpox virus	host range protein	0

IDP90119 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_029	68449103		ankyrin-like protein [Monkeypox virus]	442	similar to VACV-COP-M1L, MPXV-ZAI96-O1L	Community Requests	1N11	16.3%	Monkeypox virus

IDP00907 (show subtarget assignments)	1	in_crystallization_trials	No	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04485 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3430	115349058		conserved hypothetical protein [Yersinia...	206	conserved gene; putative drug target function;	Phase 4: April 2009	1N3B	62.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01858 (show subtarget assignments)	1	cloned	No	CBU_0993	29541575	def	peptide deformylase [Coxiella burnetii R...	170	Conserved; Drug target functions	Phase 3: June 2008	1N5N	47.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP90280 (show subtarget assignments)	8	selected	No	TGME49_004420	211965378		oocyst wall protein COWP, putative [Toxo...	499	Unpublished data from a differentiation mutagenesis screen indicate that the ooc...	Community Requests	1N7D	19%	Toxoplasma gondii

IDP91691 (show subtarget assignments)	8	selected	No	NP_001034438	86788132	EFEMP1	EGF-containing fibulin-like extracellula...	493	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1N7D	19.7%	Homo sapiens

IDP91694 (show subtarget assignments)	8	selected	No	NP_001989	51873055	FBLN2	fibulin-2 isoform b precursor [Homo sapi...	1184	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1N7D	8.7%	Homo sapiens

IDP04584 (show subtarget assignments)	1	purified	No	BAS0112	49183146		50S ribosomal protein L23 [Bacillus anth...	96	Proposed to be essential proteins	Phase 4: April 2009	1N88	43.8%	Bacillus anthracis

IDP91428 (show subtarget assignments)	8	soluble	No	VV1_0495	27363959		phospho-2-dehydro-3-deoxyheptonate aldol...	356	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1N8F	52%	Vibrio vulnificus

IDP05333 (show subtarget assignments)	1	cloned	No	BAS2031	49185042	-	aspartyl-tRNA synthetase [Bacillus anthr...	432	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1N9W	49.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP90308 (show subtarget assignments)	8	cloned	No	CT_700	3329154		hypothetical protein [Chlamydia trachoma...	441	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1NA0	6.3%	Chlamydia trachomatis

IDP05506 (show subtarget assignments)	1	soluble	No	CD1232	126698828		putative lipoprotein [Clostridium diffic...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NA0	15.8%	Clostridium difficile	Unknown function: General

IDP00323 (show subtarget assignments)	1	crystallized	No	Cj0858c	15792196	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	418	Drug Target Function	Phase 2: March 2008	1NAW	49%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00594 (show subtarget assignments)	0	work_stopped	No	YPO3569	16123713	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	420	Conserved Gene / Pathway	Phase 2: March 2008	1NAW	91.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91797 (show subtarget assignments)	8	in_crystallization_trials	No	CAA23892	43749		neomycin phosphotransferase [Escherichia...	264	other biological interest / Kinase	Community Requests	1ND4	100%	Escherichia coli

IDP91186 (show subtarget assignments)	1	in_crystallization_trials	No	CAA37605	47078		unnamed protein product [Streptomyces gr...	272	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ND4	39.8%	Streptomyces griseus

IDP92074 (show subtarget assignments)	8	selected	No	TGME49_095350	237844373		nucleoside diphosphate kinase, putative ...	155	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1NDL	66.5%	Toxoplasma gondii

IDP00965 (show subtarget assignments)	1	purified	No	STM1463	16764811	add	adenosine deaminase	333	Conserved Gene / Pathway	Phase 2: March 2008	1NDV	33.8%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02644 (show subtarget assignments)	1	purified	No	FTT0074	56707253	sdhA	succinate dehydrogenase, catalytic and N...	597	Conserved; Drug target functions	Phase 3: June 2008	1NEK	61.4%	Francisella tularensis	Energy metabolism	TCA cycle

IDP04070 (show subtarget assignments)	1	cloned	No	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP02194 (show subtarget assignments)	1	expressed	No	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP01445 (show subtarget assignments)	1	soluble	No	VC2088	15642088	sdhB	succinate dehydrogenase iron-sulfur subu...	236	Conserved Gene / Pathway	Phase 2: March 2008	1NEK	77.2%	Vibrio cholerae	Energy metabolism	TCA cycle

IDP91720 (show subtarget assignments)	8	selected	No	NP_068810	223468676	RELA	transcription factor p65 isoform 1 [Homo...	551	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1NFI	54.4%	Homo sapiens

IDP92135 (show subtarget assignments)	8	selected	No	TGME49_045670	211964661		pyruvate dehydrogenase, putative [Toxopl...	635	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1NI4	20.6%	Toxoplasma gondii

IDP00915 (show subtarget assignments)	1	in_crystallization_trials	No	STM0236	16763626	tilS	tRNA(Ile)-lysidine synthetase	430	Drug Target Function	Phase 2: March 2008	1NI5	75.3%	Salmonella enterica	Cellular processes	Cell division

IDP00465 (show subtarget assignments)	1	cloned	No	YPO1062	16121362	tilS	tRNA(Ile)-lysidine synthetase	460	Virulence Associated Factor	Phase 2: March 2008	1NI5	52.8%	Yersinia pestis	Cellular processes	Cell division

IDP02714 (show subtarget assignments)	1	purified	No	FTT1231	56708293	mesJ	PP-loop family protein [Francisella tula...	398	Conserved; Drug target functions	Phase 3: June 2008	1NI5	27.3%	Francisella tularensis	Cellular processes	Cell division

IDP90666 (show subtarget assignments)	8	purified	No	VC2242	15642240		mesJ protein [Vibrio cholerae O1 biovar ...	440	Predicted Essential	Community Requests	1NI5	44.1%	Vibrio cholerae

IDP01043 (show subtarget assignments)	1	soluble	No	STM2985	16766289	ygdK	putative FeS center assembly protein	147	Conserved Gene / Pathway	Phase 2: March 2008	1NI7	86.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00991 (show subtarget assignments)	1	in_crystallization_trials	No	STM2212	16765541	yeiR	putative cobalamin biosynthetic protein ...	328	Conserved Gene / Pathway	Phase 2: March 2008	1NIJ	18.9%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91683 (show subtarget assignments)	8	selected	No	MYC_HUMAN	0			439	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1NKP	18.9%	Homo sapiens

IDP04591 (show subtarget assignments)	1	cloned	No	BAS0138	49183172		50S ribosomal protein L17 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1NKW	50.8%	Bacillus anthracis

IDP04582 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0110	49183144		50S ribosomal protein L3 [Bacillus anthr...	210	Proposed to be essential proteins	Phase 4: April 2009	1NKW	53.3%	Bacillus anthracis

IDP04732 (show subtarget assignments)	1	cloned	No	BAS5341	49188325		50S ribosomal protein L34 [Bacillus anth...	44	Proposed to be essential proteins	Phase 4: April 2009	1NKW	65.9%	Bacillus anthracis

IDP01762 (show subtarget assignments)	1	soluble	No	FTT0557	56707687		AhpC/TSA family protein [Francisella tul...	174	Drug Target	Phase 3: June 2008	1NM3	54%	Francisella tularensis	Cellular processes	Detoxification

IDP91457 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0163	27363646		hypothetical protein VV1_0163 [Vibrio vu...	252	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1NMO	57.9%	Vibrio vulnificus

IDP04457 (show subtarget assignments)	1	soluble	No	YPO1386	115347145	ansB	putative L-asparaginase II precursor [Ye...	345	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1NNS	71.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02524 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1852	47527143	ilvC-2	ketol-acid reductoisomerase [Bacillus an...	335	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	56.1%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02330 (show subtarget assignments)	1	cloned	No	GBAA1419	47526691	ilvC-1	ketol-acid reductoisomerase [Bacillus an...	336	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	55.7%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP90757 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0632	15791992	ilvC	ketol-acid reductoisomerase [Campylobact...	340	Predicted Essential	Community Requests	1NP3	64.7%	Campylobacter jejuni

IDP02314 (show subtarget assignments)	1	cloned	No	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90721 (show subtarget assignments)	8	crystallized	No	YPO1610	16121878	aroE	shikimate 5-dehydrogenase [Yersinia pest...	292	Predicted Essential	Community Requests	1NPY	52.4%	Yersinia pestis

IDP90926 (show subtarget assignments)	8	purified	No	STM3859	16767143	aroE	shikimate 5-dehydrogenase [Salmonella ty...	272	Predicted Essential	Community Requests	1NPY	55.5%	Salmonella enterica

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP91015 (show subtarget assignments)	8	selected	No	y2404	22126288	psn	pesticin/yersiniabactin outer membrane r...	673	TonB-dependent outer membrane receptor (yersiniabactin-binding)	Community Requests	1NQF	23.8%	Yersinia pestis

IDP02587 (show subtarget assignments)	1	cloned	No	STM2571	16765891	murQ	N-acetylmuramic acid-6-phosphate etheras...	297	Conserved; Drug target functions	Phase 3: June 2008	1NRI	51.9%	Salmonella enterica	Unknown function	General

IDP91269 (show subtarget assignments)	8	soluble	No	NT05BA2958	49179731		acetyltransferase, GNAT family [Bacillus...	180	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1NSL	30.6%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP02783 (show subtarget assignments)	1	expressed	No	FTT0425c	56707572	asd	aspartate-semialdehyde dehydrogenase [Fr...	364	Conserved; Drug target functions	Phase 3: June 2008	1NWC	50%	Francisella tularensis	Amino acid biosynthesis	Aspartate family

IDP00870 (show subtarget assignments)	1	cloned	No	STM4470	16767715	yjgD	hypothetical protein STM4470	138	Conserved Gene / Pathway	Phase 2: March 2008	1NXI	54.3%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP05626 (show subtarget assignments)	1	soluble	No	CD1430	126699034		putative exported polysaccharide deacety...	274	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NY1	37.2%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91185 (show subtarget assignments)	8	cloned	No	AAC46367	2352978			477	virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...	Community Requests	1NY5	31.9%	Vibrio cholerae

IDP05080 (show subtarget assignments)	1	cloned	No	lmo1559	16803599	thrS	threonyl-tRNA synthetase [Listeria monoc...	640	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NYQ	72%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05335 (show subtarget assignments)	1	expressed	No	BAS2222	49185231	-	threonyl-tRNA synthetase [Bacillus anthr...	639	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NYQ	50.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05712 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4472	49187467	-	threonyl-tRNA synthetase [Bacillus anthr...	645	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NYQ	69.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP91167 (show subtarget assignments)	8	expressed	No	STM3401	16766690	aroE	shikimate 5-dehydrogenase	272	potential drug target / Shikimate pathway enzyme	Community Requests	1NYT	84.9%	Salmonella enterica

IDP02433 (show subtarget assignments)	1	expressed	No	CBU_0010	29540636	aroE	shikimate 5-dehydrogenase [Coxiella burn...	272	Conserved; Drug target functions	Phase 3: June 2008	1NYT	46.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP05224 (show subtarget assignments)	1	cloned	No	VC_0595	9655026		glutamyl-tRNA synthetase-related protein...	304	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	55.3%	Vibrio cholerae	Unknown function: General

IDP05342 (show subtarget assignments)	1	soluble	No	YPO3398	16123547	-	glutamyl-Q tRNA(Asp) synthetase [Yersini...	384	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	52.1%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05772 (show subtarget assignments)	1	cloned	No	Z3171	12516188	dacD	penicillin binding protein 6b [Escherich...	425	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZO	40.7%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00982 (show subtarget assignments)	1	soluble	No	STM2062	16765392	dacD	D-alanyl-D-alanine carboxypeptidase	390	Drug Target Function	Phase 2: March 2008	1NZO	45.1%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487 (show subtarget assignments)	1	soluble	No	VCA0270	15601038		D-alanyl-D-alanine carboxypeptidase	389	Drug Target Function	Phase 2: March 2008	1NZO	44.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02108 (show subtarget assignments)	1	in_crystallization_trials	No	STM3680	16766965	aldB	aldehyde dehydrogenase B [Salmonella typ...	512	Conserved; Drug target functions	Phase 3: June 2008	1NZW	40.6%	Salmonella enterica	Energy metabolism	Other

IDP05277 (show subtarget assignments)	1	expressed	No	YPO2630	16122843	glnS	glutaminyl-tRNA synthetase [Yersinia pes...	598	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1O0B	80.3%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP04607 (show subtarget assignments)	1	cloned	No	BAS3700	49186699		ribonuclease III [Bacillus anthracis str...	245	Proposed to be essential proteins	Phase 4: April 2009	1O0W	40%	Bacillus anthracis

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04300 (show subtarget assignments)	1	purified	No	CPF_0672	110798984	purE	phosphoribosylaminoimidazole carboxylase...	159	conserved gene; putative drug target function;	Phase 4: April 2009	1O4V	51.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90558 (show subtarget assignments)	8	purified	No	Cj0912c	15792241	cysM	cysteine synthase A [Campylobacter jejun...	299	Predicted Essential	Community Requests	1O58	52.5%	Campylobacter jejuni

IDP02241 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1129c	56708206		hypothetical protein FTT1129c [Francisel...	561	Drug Target	Phase 3: June 2008	1O5Z	11.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02768 (show subtarget assignments)	1	purified	No	GBAA4689	47529988	folC	folylpolyglutamate synthase [Bacillus an...	433	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1O5Z	34.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02773 (show subtarget assignments)	1	crystallized	No	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01715 (show subtarget assignments)	1	expressed	No	Cj0351	15791719	fliN	flagellar motor switch protein [Campylob...	102	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1O6A	29.4%	Campylobacter jejuni	Cell envelope	Other

IDP01658 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0059c	15791451	fliY	flagellar motor switch protein FliY [Cam...	280	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1O6A	15.4%	Campylobacter jejuni	Cell envelope	Other

IDP05282 (show subtarget assignments)	1	soluble	No	CD0228	126697799	fliN	flagellar motor switch protein [Clostrid...	104	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1O6A	23.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01225 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00691 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2103	57286319		UDP-N-acetylglucosamine 2-epimerase	375	Drug Target Function	Phase 2: March 2008	1O6C	61.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05731 (show subtarget assignments)	1	cloned	No	CD1033	126698617	mnaA	UDP-N-acetylglucosamine 2-epimerase [Clo...	374	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1O6C	60.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00652 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0151	57285354	cap5P	UDP-N-acetylglucosamine 2-epimerase Cap5...	391	Conserved Gene / Pathway	Phase 2: March 2008	1O6C	56%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05553 (show subtarget assignments)	1	soluble	No	lmo1136	16803176	-	hypothetical protein lmo1136 [Listeria m...	539	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.6%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP05666 (show subtarget assignments)	1	soluble	No	lmo0433	16802477	inlA	internalin A [Listeria monocytogenes EGD...	800	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	57.6%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP05548 (show subtarget assignments)	1	cloned	No	lmo0409	16802454	-	hypothetical protein lmo0409 [Listeria m...	821	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.8%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP05699 (show subtarget assignments)	1	cloned	No	lmo2396	16804434	-	hypothetical protein lmo2396 [Listeria m...	940	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	10.9%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP00403 (show subtarget assignments)	1	soluble	No	YPO1125	16121425	pal	peptidoglycan-associated outer membrane ...	168	Conserved Gene / Pathway	Phase 2: March 2008	1OAP	58.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00661 (show subtarget assignments)	1	purified	No	SACOL0827	57284289		acetyltransferase, putative	161	Drug Target Function	Phase 2: March 2008	1OCX	30.4%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP00964 (show subtarget assignments)	0	work_stopped	No	STM1439	16764787	ydhF	putative aldo/keto reductase	298	Conserved Gene / Pathway	Phase 2: March 2008	1OG6	88.9%	Salmonella enterica	Unknown function	General

IDP00606 (show subtarget assignments)	1	cloned	No	SACOL1933	57286280		ThiJ/PfpI family protein	171	Drug Target Function	Phase 2: March 2008	1OI4	48.8%	Staphylococcus aureus	Unknown function	General

IDP90543 (show subtarget assignments)	8	cloned	No	VC2182	15642181	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	295	Predicted Essential	Community Requests	1OJ4	58%	Vibrio cholerae

IDP90942 (show subtarget assignments)	8	expressed	No	A55_2372	124113375	ispE	4-diphosphocytidyl-2C-methyl-D-erythrito...	194	We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...	Community Requests	1OJ4	59.8%	Vibrio cholerae

IDP90560 (show subtarget assignments)	8	in_crystallization_trials	No	YPO2014	16122257	ipk	4-diphosphocytidyl-2-C-methyl-D-erythrit...	299	Predicted Essential	Community Requests	1OJ4	70.9%	Yersinia pestis

IDP90110
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_015

68449089

ankyrin-like protein [Monkeypox virus]

660

Community Requests

1N0Q

4.4%

Monkeypox virus

IDP90216
(show subtarget assignments)

8

expressed

No

MYXV_gp008

9633799

m005L

m005L, m5, M-T5

483

ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.

Community Requests

1N0R

8.5%

Myxoma virus

host range factor, host defense modulator

0

IDP90193
(show subtarget assignments)

8

cloned

No

AAM13637.1

20153176

CPXV198 CDS

CPXV198 protein

558

ankyrin-like protein

Community Requests

1N11

11.1%

Cowpox virus

conserved hypothetical proteins

0

IDP90184
(show subtarget assignments)

8

expressed

No

AAM13486.1

20153025

CPXV039 CDS

CPXV039 protein

473

ankyrin repeat protein

Community Requests

1N11

14.4%

Cowpox virus

conserved hypothetical proteins

0

IDP90207
(show subtarget assignments)

8

soluble

No

MYXV_gp152

9633784

m149R

490

ankyrin motif, similar to VACV-Cop:B4R

Community Requests

1N11

14.9%

Myxoma virus

host range factor

0

IDP90137
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_179

68449250

ankyrin-like protein [Monkeypox virus]

561

similar to VACV-COP-B4R, MPXV-ZAI96-B5R

Community Requests

1N11

11.2%

Monkeypox virus

IDP90178
(show subtarget assignments)

8

purified

No

AAM13472.1

20153011

VHR1

VHR1 or CPXV025 protein

668

ankyrin-like protein, CP77

Community Requests

1N11

10%

Cowpox virus

host range protein

0

IDP90119
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_029

68449103

ankyrin-like protein [Monkeypox virus]

442

similar to VACV-COP-M1L, MPXV-ZAI96-O1L

Community Requests

1N11

16.3%

Monkeypox virus

IDP00907
(show subtarget assignments)

1

in_crystallization_trials

No

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04485
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3430

115349058

conserved hypothetical protein [Yersinia...

206

conserved gene; putative drug target function;

Phase 4: April 2009

1N3B

62.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01858
(show subtarget assignments)

1

cloned

No

CBU_0993

29541575

def

peptide deformylase [Coxiella burnetii R...

170

Conserved; Drug target functions

Phase 3: June 2008

1N5N

47.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP90280
(show subtarget assignments)

8

selected

No

TGME49_004420

211965378

oocyst wall protein COWP, putative [Toxo...

499

Unpublished data from a differentiation mutagenesis screen indicate that the ooc...

Community Requests

1N7D

19%

Toxoplasma gondii

IDP91691
(show subtarget assignments)

8

selected

No

NP_001034438

86788132

EFEMP1

EGF-containing fibulin-like extracellula...

493

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1N7D

19.7%

Homo sapiens

IDP91694
(show subtarget assignments)

8

selected

No

NP_001989

51873055

FBLN2

fibulin-2 isoform b precursor [Homo sapi...

1184

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1N7D

8.7%

Homo sapiens

IDP04584
(show subtarget assignments)

1

purified

No

BAS0112

49183146

50S ribosomal protein L23 [Bacillus anth...

96

Proposed to be essential proteins

Phase 4: April 2009

1N88

43.8%

Bacillus anthracis

IDP91428
(show subtarget assignments)

8

soluble

No

VV1_0495

27363959

phospho-2-dehydro-3-deoxyheptonate aldol...

356

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1N8F

52%

Vibrio vulnificus

IDP05333
(show subtarget assignments)

1

cloned

No

BAS2031

49185042

-

aspartyl-tRNA synthetase [Bacillus anthr...

432

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1N9W

49.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP90308
(show subtarget assignments)

8

cloned

No

CT_700

3329154

hypothetical protein [Chlamydia trachoma...

441

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1NA0

6.3%

Chlamydia trachomatis

IDP05506
(show subtarget assignments)

1

soluble

No

CD1232

126698828

putative lipoprotein [Clostridium diffic...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NA0

15.8%

Clostridium difficile

Unknown function: General

IDP00323
(show subtarget assignments)

1

crystallized

No

Cj0858c

15792196

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

418

Drug Target Function

Phase 2: March 2008

1NAW

49%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00594
(show subtarget assignments)

0

work_stopped

No

YPO3569

16123713

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

420

Conserved Gene / Pathway

Phase 2: March 2008

1NAW

91.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91797
(show subtarget assignments)

8

in_crystallization_trials

No

CAA23892

43749

neomycin phosphotransferase [Escherichia...

264

other biological interest / Kinase

Community Requests

1ND4

100%

Escherichia coli

IDP91186
(show subtarget assignments)

1

in_crystallization_trials

No

CAA37605

47078

unnamed protein product [Streptomyces gr...

272

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ND4

39.8%

Streptomyces griseus

IDP92074
(show subtarget assignments)

8

selected

No

TGME49_095350

237844373

nucleoside diphosphate kinase, putative ...

155

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1NDL

66.5%

Toxoplasma gondii

IDP00965
(show subtarget assignments)

1

purified

No

STM1463

16764811

add

adenosine deaminase

333

Conserved Gene / Pathway

Phase 2: March 2008

1NDV

33.8%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02644
(show subtarget assignments)

1

purified

No

FTT0074

56707253

sdhA

succinate dehydrogenase, catalytic and N...

597

Conserved; Drug target functions

Phase 3: June 2008

1NEK

61.4%

Francisella tularensis

Energy metabolism

TCA cycle

IDP04070
(show subtarget assignments)

1

cloned

No

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP02194
(show subtarget assignments)

1

expressed

No

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP01445
(show subtarget assignments)

1

soluble

No

VC2088

15642088

sdhB

succinate dehydrogenase iron-sulfur subu...

236

Conserved Gene / Pathway

Phase 2: March 2008

1NEK

77.2%

Vibrio cholerae

Energy metabolism

TCA cycle

IDP91720
(show subtarget assignments)

8

selected

No

NP_068810

223468676

RELA

transcription factor p65 isoform 1 [Homo...

551

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1NFI

54.4%

Homo sapiens

IDP92135
(show subtarget assignments)

8

selected

No

TGME49_045670

211964661

pyruvate dehydrogenase, putative [Toxopl...

635

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1NI4

20.6%

Toxoplasma gondii

IDP00915
(show subtarget assignments)

1

in_crystallization_trials

No

STM0236

16763626

tilS

tRNA(Ile)-lysidine synthetase

430

Drug Target Function

Phase 2: March 2008

1NI5

75.3%

Salmonella enterica

Cellular processes

Cell division

IDP00465
(show subtarget assignments)

1

cloned

No

YPO1062

16121362

tilS

tRNA(Ile)-lysidine synthetase

460

Virulence Associated Factor

Phase 2: March 2008

1NI5

52.8%

Yersinia pestis

Cellular processes

Cell division

IDP02714
(show subtarget assignments)

1

purified

No

FTT1231

56708293

mesJ

PP-loop family protein [Francisella tula...

398

Conserved; Drug target functions

Phase 3: June 2008

1NI5

27.3%

Francisella tularensis

Cellular processes

Cell division

IDP90666
(show subtarget assignments)

8

purified

No

VC2242

15642240

mesJ protein [Vibrio cholerae O1 biovar ...

440

Predicted Essential

Community Requests

1NI5

44.1%

Vibrio cholerae

IDP01043
(show subtarget assignments)

1

soluble

No

STM2985

16766289

ygdK

putative FeS center assembly protein

147

Conserved Gene / Pathway

Phase 2: March 2008

1NI7

86.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00991
(show subtarget assignments)

1

in_crystallization_trials

No

STM2212

16765541

yeiR

putative cobalamin biosynthetic protein ...

328

Conserved Gene / Pathway

Phase 2: March 2008

1NIJ

18.9%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91683
(show subtarget assignments)

8

selected

No

MYC_HUMAN

0

439

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1NKP

18.9%

Homo sapiens

IDP04591
(show subtarget assignments)

1

cloned

No

BAS0138

49183172

50S ribosomal protein L17 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1NKW

50.8%

Bacillus anthracis

IDP04582
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0110

49183144

50S ribosomal protein L3 [Bacillus anthr...

210

Proposed to be essential proteins

Phase 4: April 2009

1NKW

53.3%

Bacillus anthracis

IDP04732
(show subtarget assignments)

1

cloned

No

BAS5341

49188325

50S ribosomal protein L34 [Bacillus anth...

44

Proposed to be essential proteins

Phase 4: April 2009

1NKW

65.9%

Bacillus anthracis

IDP01762
(show subtarget assignments)

1

soluble

No

FTT0557

56707687

AhpC/TSA family protein [Francisella tul...

174

Drug Target

Phase 3: June 2008

1NM3

54%

Francisella tularensis

Cellular processes

Detoxification

IDP91457
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0163

27363646

hypothetical protein VV1_0163 [Vibrio vu...

252

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1NMO

57.9%

Vibrio vulnificus

IDP04457
(show subtarget assignments)

1

soluble

No

YPO1386

115347145

ansB

putative L-asparaginase II precursor [Ye...

345

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1NNS

71.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02524
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1852

47527143

ilvC-2

ketol-acid reductoisomerase [Bacillus an...

335

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

56.1%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02330
(show subtarget assignments)

1

cloned

No

GBAA1419

47526691

ilvC-1

ketol-acid reductoisomerase [Bacillus an...

336

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

55.7%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP90757
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0632

15791992

ilvC

ketol-acid reductoisomerase [Campylobact...

340

Predicted Essential

Community Requests

1NP3

64.7%

Campylobacter jejuni

IDP02314
(show subtarget assignments)

1

cloned

No

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90721
(show subtarget assignments)

8

crystallized

No

YPO1610

16121878

aroE

shikimate 5-dehydrogenase [Yersinia pest...

292

Predicted Essential

Community Requests

1NPY

52.4%

Yersinia pestis

IDP90926
(show subtarget assignments)

8

purified

No

STM3859

16767143

aroE

shikimate 5-dehydrogenase [Salmonella ty...

272

Predicted Essential

Community Requests

1NPY

55.5%

Salmonella enterica

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP91015
(show subtarget assignments)

8

selected

No

y2404

22126288

psn

pesticin/yersiniabactin outer membrane r...

673

TonB-dependent outer membrane receptor (yersiniabactin-binding)

Community Requests

1NQF

23.8%

Yersinia pestis

IDP02587
(show subtarget assignments)

1

cloned

No

STM2571

16765891

murQ

N-acetylmuramic acid-6-phosphate etheras...

297

Conserved; Drug target functions

Phase 3: June 2008

1NRI

51.9%

Salmonella enterica

Unknown function

General

IDP91269
(show subtarget assignments)

8

soluble

No

NT05BA2958

49179731

acetyltransferase, GNAT family [Bacillus...

180

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1NSL

30.6%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP02783
(show subtarget assignments)

1

expressed

No

FTT0425c

56707572

asd

aspartate-semialdehyde dehydrogenase [Fr...

364

Conserved; Drug target functions

Phase 3: June 2008

1NWC

50%

Francisella tularensis

Amino acid biosynthesis

Aspartate family

IDP00870
(show subtarget assignments)

1

cloned

No

STM4470

16767715

yjgD

hypothetical protein STM4470

138

Conserved Gene / Pathway

Phase 2: March 2008

1NXI

54.3%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP05626
(show subtarget assignments)

1

soluble

No

CD1430

126699034

putative exported polysaccharide deacety...

274

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NY1

37.2%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91185
(show subtarget assignments)

8

cloned

No

AAC46367

2352978

477

virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...

Community Requests

1NY5

31.9%

Vibrio cholerae

IDP05080
(show subtarget assignments)

1

cloned

No

lmo1559

16803599

thrS

threonyl-tRNA synthetase [Listeria monoc...

640

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NYQ

72%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05335
(show subtarget assignments)

1

expressed

No

BAS2222

49185231

-

threonyl-tRNA synthetase [Bacillus anthr...

639

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NYQ

50.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05712
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4472

49187467

-

threonyl-tRNA synthetase [Bacillus anthr...

645

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NYQ

69.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP91167
(show subtarget assignments)

8

expressed

No

STM3401

16766690

aroE

shikimate 5-dehydrogenase

272

potential drug target / Shikimate pathway enzyme

Community Requests

1NYT

84.9%

Salmonella enterica

IDP02433
(show subtarget assignments)

1

expressed

No

CBU_0010

29540636

aroE

shikimate 5-dehydrogenase [Coxiella burn...

272

Conserved; Drug target functions

Phase 3: June 2008

1NYT

46.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP05224
(show subtarget assignments)

1

cloned

No

VC_0595

9655026

glutamyl-tRNA synthetase-related protein...

304

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

55.3%

Vibrio cholerae

Unknown function: General

IDP05342
(show subtarget assignments)

1

soluble

No

YPO3398

16123547

-

glutamyl-Q tRNA(Asp) synthetase [Yersini...

384

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

52.1%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05772
(show subtarget assignments)

1

cloned

No

Z3171

12516188

dacD

penicillin binding protein 6b [Escherich...

425

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZO

40.7%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00982
(show subtarget assignments)

1

soluble

No

STM2062

16765392

dacD

D-alanyl-D-alanine carboxypeptidase

390

Drug Target Function

Phase 2: March 2008

1NZO

45.1%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487
(show subtarget assignments)

1

soluble

No

VCA0270

15601038

D-alanyl-D-alanine carboxypeptidase

389

Drug Target Function

Phase 2: March 2008

1NZO

44.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02108
(show subtarget assignments)

1

in_crystallization_trials

No

STM3680

16766965

aldB

aldehyde dehydrogenase B [Salmonella typ...

512

Conserved; Drug target functions

Phase 3: June 2008

1NZW

40.6%

Salmonella enterica

Energy metabolism

Other

IDP05277
(show subtarget assignments)

1

expressed

No

YPO2630

16122843

glnS

glutaminyl-tRNA synthetase [Yersinia pes...

598

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1O0B

80.3%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP04607
(show subtarget assignments)

1

cloned

No

BAS3700

49186699

ribonuclease III [Bacillus anthracis str...

245

Proposed to be essential proteins

Phase 4: April 2009

1O0W

40%

Bacillus anthracis

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04300
(show subtarget assignments)

1

purified

No

CPF_0672

110798984

purE

phosphoribosylaminoimidazole carboxylase...

159

conserved gene; putative drug target function;

Phase 4: April 2009

1O4V

51.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90558
(show subtarget assignments)

8

purified

No

Cj0912c

15792241

cysM

cysteine synthase A [Campylobacter jejun...

299

Predicted Essential

Community Requests

1O58

52.5%

Campylobacter jejuni

IDP02241
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1129c

56708206

hypothetical protein FTT1129c [Francisel...

561

Drug Target

Phase 3: June 2008

1O5Z

11.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02768
(show subtarget assignments)

1

purified

No

GBAA4689

47529988

folC

folylpolyglutamate synthase [Bacillus an...

433

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1O5Z

34.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02773
(show subtarget assignments)

1

crystallized

No

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01715
(show subtarget assignments)

1

expressed

No

Cj0351

15791719

fliN

flagellar motor switch protein [Campylob...

102

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1O6A

29.4%

Campylobacter jejuni

Cell envelope

Other

IDP01658
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0059c

15791451

fliY

flagellar motor switch protein FliY [Cam...

280

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1O6A

15.4%

Campylobacter jejuni

Cell envelope

Other

IDP05282
(show subtarget assignments)

1

soluble

No

CD0228

126697799

fliN

flagellar motor switch protein [Clostrid...

104

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1O6A

23.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01225
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00691
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2103

57286319

UDP-N-acetylglucosamine 2-epimerase

375

Drug Target Function

Phase 2: March 2008

1O6C

61.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05731
(show subtarget assignments)

1

cloned

No

CD1033

126698617

mnaA

UDP-N-acetylglucosamine 2-epimerase [Clo...

374

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1O6C

60.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00652
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0151

57285354

cap5P

UDP-N-acetylglucosamine 2-epimerase Cap5...

391

Conserved Gene / Pathway

Phase 2: March 2008

1O6C

56%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05553
(show subtarget assignments)

1

soluble

No

lmo1136

16803176

-

hypothetical protein lmo1136 [Listeria m...

539

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.6%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP05666
(show subtarget assignments)

1

soluble

No

lmo0433

16802477

inlA

internalin A [Listeria monocytogenes EGD...

800

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

57.6%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP05548
(show subtarget assignments)

1

cloned

No

lmo0409

16802454

-

hypothetical protein lmo0409 [Listeria m...

821

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.8%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP05699
(show subtarget assignments)

1

cloned

No

lmo2396

16804434

-

hypothetical protein lmo2396 [Listeria m...

940

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

10.9%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP00403
(show subtarget assignments)

1

soluble

No

YPO1125

16121425

pal

peptidoglycan-associated outer membrane ...

168

Conserved Gene / Pathway

Phase 2: March 2008

1OAP

58.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00661
(show subtarget assignments)

1

purified

No

SACOL0827

57284289

acetyltransferase, putative

161

Drug Target Function

Phase 2: March 2008

1OCX

30.4%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP00964
(show subtarget assignments)

0

work_stopped

No

STM1439

16764787

ydhF

putative aldo/keto reductase

298

Conserved Gene / Pathway

Phase 2: March 2008

1OG6

88.9%

Salmonella enterica

Unknown function

General

IDP00606
(show subtarget assignments)

1

cloned

No

SACOL1933

57286280

ThiJ/PfpI family protein

171

Drug Target Function

Phase 2: March 2008

1OI4

48.8%

Staphylococcus aureus

Unknown function

General

IDP90543
(show subtarget assignments)

8

cloned

No

VC2182

15642181

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

295

Predicted Essential

Community Requests

1OJ4

58%

Vibrio cholerae

IDP90942
(show subtarget assignments)

8

expressed

No

A55_2372

124113375

ispE

4-diphosphocytidyl-2C-methyl-D-erythrito...

194

We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...

Community Requests

1OJ4

59.8%

Vibrio cholerae

IDP90560
(show subtarget assignments)

8

in_crystallization_trials

No

YPO2014

16122257

ipk

4-diphosphocytidyl-2-C-methyl-D-erythrit...

299

Predicted Essential

Community Requests

1OJ4

70.9%

Yersinia pestis