Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05133 (show subtarget assignments)	1	cloned	No	CD0264	126697836	flhF	flagellar biosynthesis regulator FlhF [C...	338	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J37	26%	Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP90115 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_024	68449098		kelch-like protein [Monkeypox virus]	176	similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L	Community Requests	2XN4	26.1%	Monkeypox virus

IDP04470 (show subtarget assignments)	1	cloned	No	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01517 (show subtarget assignments)	1	expressed	No	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP02597 (show subtarget assignments)	1	expressed	No	YPO3472	16123618		putative sugar binding protein [Yersinia...	437	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1EU8	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01036 (show subtarget assignments)	1	in_crystallization_trials	No	STM2897	16766203	invE	invasion protein	372	Conserved Gene / Pathway	Phase 2: March 2008	2VJ5	26.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP01020 (show subtarget assignments)	1	expressed	No	STM2110	16765440	wcaF	putative colanic acid biosynthesis acety...	184	Essential Gene	Phase 2: March 2008	3SRT	26.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00214 (show subtarget assignments)	1	expressed	No	YPO2252	16122476	-	putative toxin transport protein	712	Virulence	Phase 1: October 2007	2YL4	26.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01990 (show subtarget assignments)	0	work_stopped	No	Cj1435c	15792753		hypothetical protein Cj1435c [Campylobac...	211	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FVV	26.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00778 (show subtarget assignments)	1	cloned	No	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00417 (show subtarget assignments)	1	cloned	No	YPO2604	16122817	pbpA	penicillin-binding protein 2	631	Drug Target Function	Phase 2: March 2008	3OC2	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406 (show subtarget assignments)	1	cloned	No	YPO3410	16123559		hypothetical protein YPO3410	115	Virulence Associated Factor	Phase 2: March 2008	3UTK	26.1%	Yersinia pestis	Cell envelope	Other

IDP05698 (show subtarget assignments)	1	cloned	No	lmo2186	16804225	-	hypothetical protein lmo2186 [Listeria m...	207	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O6P	26.1%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP90758 (show subtarget assignments)	8	cloned	No	VC1149	15641162		glutamate decarboxylase, putative [Vibri...	548	Predicted Essential	Community Requests	2OKJ	26.1%	Vibrio cholerae

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05156 (show subtarget assignments)	1	soluble	No	BA_1093	30254823		putative S-layer protein [Bacillus anthr...	344	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	26.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP90812 (show subtarget assignments)	8	soluble	No	YPO3117	16123282	hemH	ferrochelatase [Yersinia pestis CO92]	320	Predicted Essential	Community Requests	2QD2	26.2%	Yersinia pestis

IDP02472 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3785	16123919		hypothetical protein YPO3785 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1YWF	26.2%	Yersinia pestis	Energy metabolism	Sugars

IDP04639 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP92004 (show subtarget assignments)	8	selected	No	SpneCM_010100007049	298255341		sortase, SrtB family protein [Streptococ...	332	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1RZ2	26.2%	Streptococcus pneumoniae

IDP02470 (show subtarget assignments)	1	purified	No	lmo0865	16802906		hypothetical protein lmo0865 [Listeria m...	557	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	1TUO	26.2%	Listeria monocytogenes	Energy metabolism	Sugars

IDP04070 (show subtarget assignments)	1	cloned	No	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91498 (show subtarget assignments)	8	expressed	No	VP1675	28898449		translocation protein in type III secret...	351	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2JLH	26.2%	Vibrio parahaemolyticus

IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01132 (show subtarget assignments)	1	soluble	No	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02057 (show subtarget assignments)	1	soluble	No	Cj1311	15792634	neuA2	acylneuraminate cytidylyltransferase [Ca...	232	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1QWJ	26.3%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP05595 (show subtarget assignments)	1	soluble	No	BA_3346	30257889		putative 6-aminohexanoate-dimer hydrolas...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WYB	26.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP01708 (show subtarget assignments)	1	expressed	No	Cj0241c	15791613		putative iron-binding protein [Campyloba...	133	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AVK	26.3%	Campylobacter jejuni	Cellular processes	Other

IDP02399 (show subtarget assignments)	1	cloned	No	GBAA2559	47527848		D-alanyl-D-alanine carboxypeptidase fami...	338	Drug target motif; Drug target functions	Phase 3: June 2008	1XP4	26.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02335 (show subtarget assignments)	1	expressed	No	GBAA2583	47527873		hypothetical protein GBAA2583 [Bacillus ...	563	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3SKS	26.3%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP91987 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100008765	298255669		ABC transporter substrate-binding protei...	335	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3IX1	26.3%	Streptococcus pneumoniae

IDP04730 (show subtarget assignments)	1	cloned	No	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP04537 (show subtarget assignments)	8	selected	No	CAC05780	12329049	virF	VirF, member of the AraC family of trans...	262	Shigella effector protein	Community Requests	3GBG	26.3%	Shigella flexneri

IDP01144 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP05050 (show subtarget assignments)	1	purified	No	BA_5330	30259806		iron compound ABC transporter, iron comp...	333	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GFV	26.4%	Bacillus anthracis	Transport and binding proteins: Cations and iron carrying compounds

IDP05631 (show subtarget assignments)	1	crystallized	No	CD1979	126699588		ABC transporter, substrate-binding prote...	337	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	26.4%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP02210 (show subtarget assignments)	1	cloned	No	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP01628 (show subtarget assignments)	1	cloned	No	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP05137 (show subtarget assignments)	1	soluble	No	CD0227	126697798		hypothetical protein CD0227 [Clostridium...	142	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2QUP	26.4%	Clostridium difficile	Hypothetical proteins: Conserved

IDP05444 (show subtarget assignments)	1	soluble	No	lmo0768	16802810	-	hypothetical protein lmo0768 [Listeria m...	417	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	26.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP04110 (show subtarget assignments)	1	expressed	No	YPO2440	218929529	yfeB	ATP-binding transport protein [Yersinia ...	296	virulence factor; conserved gene;	Phase 4: April 2009	3GFO	26.4%	Yersinia pestis	Unknown function	General

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04140 (show subtarget assignments)	1	cloned	No	YPO3116	115348760	ascD	cdp-6-deoxy-delta-3,4-glucoseen reductas...	329	virulence factor; putative drug target function;	Phase 4: April 2009	1KRH	26.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05744 (show subtarget assignments)	1	cloned	No	CD2744	126700359	relA	putative GTP pyrophosphokinase [Clostrid...	735	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VJ7	26.4%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01206 (show subtarget assignments)	1	purified	No	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04675 (show subtarget assignments)	1	soluble	No	GBAA2291	47527591		sensor histidine kinase [Bacillus anthra...	377	putative drug target function;	Phase 4: April 2009	3A0R	26.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91816 (show subtarget assignments)	8	cloned	No	b2463	1788806	maeB	fused malic enzyme predicted oxidoreduct...	759	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1WW8	26.5%	Escherichia coli

IDP02588 (show subtarget assignments)	6	cloned	No	AAC67800	3328615	gseA	KDO Transferase [Chlamydia trachomatis D...	431	KdtA is responsible for the formation of the genus-specific lipopolysaccharide e...	Phase 3: June 2008	2XCI	26.5%	Chlamydia trachomatis	N/A	N/A

IDP02805 (show subtarget assignments)	1	expressed	No	Cj1129c	15792454	wlaC	general glycosylation pathway protein [C...	359	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3L01	26.5%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02224 (show subtarget assignments)	1	cloned	No	YPO0616	16120942		putative glycosyl hydrolase [Yersinia pe...	727	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	2X40	26.5%	Yersinia pestis	Energy metabolism	Sugars

IDP01924 (show subtarget assignments)	1	purified	No	lmo0692	16802734	cheA	two-component sensor histidine kinase Ch...	618	Known virulence-Regulation; PMID:15155625	Phase 3: June 2008	1B3Q	26.5%	Listeria monocytogenes	Cellular processes	Chemotaxis and motility

IDP04447 (show subtarget assignments)	1	expressed	No	YPO0690	218927881		putative type II secretion protein [Yers...	428	putative drug target function;	Phase 4: April 2009	2OAP	26.6%	Yersinia pestis	Cell envelope	Surface structures

IDP00346 (show subtarget assignments)	1	cloned	No	lmo0489	16802532		hypothetical protein lmo0489	664	Drug Target Function	Phase 2: March 2008	3K30	26.6%	Listeria monocytogenes	Energy metabolism	Electron transport

IDP05361 (show subtarget assignments)	1	cloned	No	BA_1162	30254880		alpha-amylase family protein [Bacillus a...	433	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1CYG	26.7%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05120 (show subtarget assignments)	1	in_crystallization_trials	No	CD0236	126697807	fliS2	flagellar protein [Clostridium difficile...	116	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VH6	26.7%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00962 (show subtarget assignments)	1	cloned	No	STM1427	16764775	cfa	cyclopropane fatty acyl phospholipid syn...	382	Drug Target Function	Phase 2: March 2008	1KP9	26.7%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02276 (show subtarget assignments)	1	expressed	No	YPO0860	16121168		sugar-binding periplasmic protein [Yersi...	333	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	26.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02300 (show subtarget assignments)	1	soluble	No	GBAA1860	47527151		alpha/beta fold family hydrolase [Bacill...	307	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3HJU	26.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP00822 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2253	57285032	femX	femX protein	421	Conserved Gene / Pathway	Phase 2: March 2008	1LRZ	26.7%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05164 (show subtarget assignments)	1	purified	No	BA_1735	30256021		putative ABC transporter, substrate-bind...	341	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EDP	26.7%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP91183 (show subtarget assignments)	8	in_pdb 3T7Y	No	CT091	15604810	yscU	type III secretion system protein [Chlam...	360	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests	3T7Y	26.7%	Chlamydia trachomatis

IDP05566 (show subtarget assignments)	1	soluble	No	lmo2569	16804607	-	hypothetical protein lmo2569 [Listeria m...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3O9P	26.7%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Plasmid functions

IDP91963 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100009553	298255821		branched-chain amino acid ABC transporte...	386	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3TD9	26.7%	Streptococcus pneumoniae

IDP01770 (show subtarget assignments)	1	expressed	No	Cj1447c	15792764	kpsT	capsular polysaccharide ABC transporter,...	220	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2BBS	26.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02802 (show subtarget assignments)	1	cloned	No	GBAA3471	47528757		short chain dehydrogenase/reductase fami...	234	Conserved; Essential;	Phase 3: June 2008	1SNY	26.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP90249 (show subtarget assignments)	8	soluble	No	VC2645	15642640		acetylornithine deacetylase [Vibrio chol...	378	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	26.8%	Vibrio cholerae

IDP00711 (show subtarget assignments)	1	soluble	No	SACOL0997	57284371		oligopeptide ABC transporter, ATP-bindin...	328	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	26.8%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP02291 (show subtarget assignments)	1	cloned	No	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01146 (show subtarget assignments)	1	cloned	No	BA_0235	30253735		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	26.8%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP04693 (show subtarget assignments)	1	cloned	No	GBAA5598	47530920		sensor histidine kinase [Bacillus anthra...	376	drug target; putative drug target function;	Phase 4: April 2009	3GIG	26.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91276 (show subtarget assignments)	8	soluble	No	NT05BA4392	49181134		ribosomal protein L11 methyltransferase ...	312	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3GRZ	26.9%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90206 (show subtarget assignments)	8	soluble	No	MYXV_gp149	9633781	m146R	m146R	108	virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L	Community Requests	2I39	26.9%	Myxoma virus	host defense modulator	0

IDP04687 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90250 (show subtarget assignments)	8	expressed	No	Z5515	15804553	argE	acetylornithine deacetylase [Escherichia...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3IC1	26.9%	Escherichia coli

IDP90248 (show subtarget assignments)	8	purified	No	BAS0467	49183495		acetylornithine deacetylase [Bacillus an...	426	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3PFO	27%	Bacillus anthracis

IDP02158 (show subtarget assignments)	1	cloned	No	Cj1617	15792922	chuD	putative haemin uptake system periplasmi...	268	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3GFV	27%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP91091 (show subtarget assignments)	8	cloned	No	APL_0387	126096663	kpsF	arabinose-5-phosphate isomerase [Actinob...	311	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	27%	Actinobacillus pleuropneumoniae

IDP00332 (show subtarget assignments)	1	purified	No	FTT1673	56708683	ribA	riboflavin biosynthesis protein ribA/GTP...	403	Drug Target Function	Phase 2: March 2008	1G57	27%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05369 (show subtarget assignments)	1	soluble	No	BA_4597	30259097		iron compound ABC transporter, iron comp...	315	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2PHZ	27%	Bacillus anthracis	Transport and binding proteins: Cations and iron carrying compounds

IDP91242 (show subtarget assignments)	8	cloned	No	HP0773	2313904		predicted coding region HP0773 [Helicoba...	363	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3BO9	27%	Helicobacter pylori

IDP00017 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4333	81581445	ribBA	Riboflavin biosynthesis protein ribBA [I...	397	Drug Target Homolog	Phase 1: October 2007	2BZ0	27%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP92037 (show subtarget assignments)	8	selected	No	TGME49_033820	237837865		DNA polymerase delta small subunit, puta...	492	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3E0J	27%	Toxoplasma gondii

IDP01120 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP91705 (show subtarget assignments)	8	selected	No	NP_004879	4757818	ATP6V1G1	V-type proton ATPase subunit G 1 [Homo s...	118	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2K88	27.1%	Homo sapiens

IDP00313 (show subtarget assignments)	1	expressed	No	CBU_0647	29653985	ribA	riboflavin biosynthesis protein RibA	406	Drug Target Function	Phase 2: March 2008	2BZ0	27.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90274 (show subtarget assignments)	8	selected	No	TGME49_015260	211968509		carbamoyl phosphate synthetase II [Toxop...	1699	Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...	Community Requests	1A9X	27.1%	Toxoplasma gondii

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00101 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF2638	30041803	mrp	putative ATPase	369	Essential	Phase 1: October 2007	2PH1	27.1%	Shigella flexneri	Unknown function	General

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05526 (show subtarget assignments)	1	soluble	No	CD1319	126698918		putative polysaccharide deacetylase [Clo...	247	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J13	27.1%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00718 (show subtarget assignments)	1	soluble	No	SACOL1434	57286085		alanine racemase family protein	361	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	27.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91612 (show subtarget assignments)	8	purified	No	BAB36911	13362959	ECs3488	hypothetical protein [Escherichia coli O...	140	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	27.1%	Escherichia coli

IDP02529 (show subtarget assignments)	1	cloned	No	Cj0003	15791402	gyrB	DNA gyrase subunit B [Campylobacter jeju...	769	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1EI1	27.2%	Campylobacter jejuni	Cell envelope	Other

IDP05652 (show subtarget assignments)	1	cloned	No	lmo0129	16802177	-	hypothetical protein lmo0129 [Listeria m...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3NE8	27.2%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00109 (show subtarget assignments)	1	in_crystallization_trials	No	NT01SF4517	30043269	recF	Rec protein	357	Essential	Phase 1: October 2007	2O5V	27.2%	Shigella flexneri	DNA metabolism	DNA replication, recombination, and repair

IDP90641 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0099	15791487	birA	biotin--protein ligase [Campylobacter je...	217	Predicted Essential	Community Requests	2EAY	27.2%	Campylobacter jejuni

IDP05133
(show subtarget assignments)

1

cloned

No

CD0264

126697836

flhF

flagellar biosynthesis regulator FlhF [C...

338

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J37

26%

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP90115
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_024

68449098

kelch-like protein [Monkeypox virus]

176

similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L

Community Requests

2XN4

26.1%

Monkeypox virus

IDP04470
(show subtarget assignments)

1

cloned

No

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01517
(show subtarget assignments)

1

expressed

No

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP02597
(show subtarget assignments)

1

expressed

No

YPO3472

16123618

putative sugar binding protein [Yersinia...

437

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1EU8

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01036
(show subtarget assignments)

1

in_crystallization_trials

No

STM2897

16766203

invE

invasion protein

372

Conserved Gene / Pathway

Phase 2: March 2008

2VJ5

26.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP01020
(show subtarget assignments)

1

expressed

No

STM2110

16765440

wcaF

putative colanic acid biosynthesis acety...

184

Essential Gene

Phase 2: March 2008

3SRT

26.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00214
(show subtarget assignments)

1

expressed

No

YPO2252

16122476

-

putative toxin transport protein

712

Virulence

Phase 1: October 2007

2YL4

26.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01990
(show subtarget assignments)

0

work_stopped

No

Cj1435c

15792753

hypothetical protein Cj1435c [Campylobac...

211

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FVV

26.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00778
(show subtarget assignments)

1

cloned

No

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00417
(show subtarget assignments)

1

cloned

No

YPO2604

16122817

pbpA

penicillin-binding protein 2

631

Drug Target Function

Phase 2: March 2008

3OC2

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406
(show subtarget assignments)

1

cloned

No

YPO3410

16123559

hypothetical protein YPO3410

115

Virulence Associated Factor

Phase 2: March 2008

3UTK

26.1%

Yersinia pestis

Cell envelope

Other

IDP05698
(show subtarget assignments)

1

cloned

No

lmo2186

16804225

-

hypothetical protein lmo2186 [Listeria m...

207

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O6P

26.1%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP90758
(show subtarget assignments)

8

cloned

No

VC1149

15641162

glutamate decarboxylase, putative [Vibri...

548

Predicted Essential

Community Requests

2OKJ

26.1%

Vibrio cholerae

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05156
(show subtarget assignments)

1

soluble

No

BA_1093

30254823

putative S-layer protein [Bacillus anthr...

344

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

26.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP90812
(show subtarget assignments)

8

soluble

No

YPO3117

16123282

hemH

ferrochelatase [Yersinia pestis CO92]

320

Predicted Essential

Community Requests

2QD2

26.2%

Yersinia pestis

IDP02472
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3785

16123919

hypothetical protein YPO3785 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1YWF

26.2%

Yersinia pestis

Energy metabolism

Sugars

IDP04639
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP92004
(show subtarget assignments)

8

selected

No

SpneCM_010100007049

298255341

sortase, SrtB family protein [Streptococ...

332

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1RZ2

26.2%

Streptococcus pneumoniae

IDP02470
(show subtarget assignments)

1

purified

No

lmo0865

16802906

hypothetical protein lmo0865 [Listeria m...

557

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

1TUO

26.2%

Listeria monocytogenes

Energy metabolism

Sugars

IDP04070
(show subtarget assignments)

1

cloned

No

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91498
(show subtarget assignments)

8

expressed

No

VP1675

28898449

translocation protein in type III secret...

351

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2JLH

26.2%

Vibrio parahaemolyticus

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01132
(show subtarget assignments)

1

soluble

No

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02057
(show subtarget assignments)

1

soluble

No

Cj1311

15792634

neuA2

acylneuraminate cytidylyltransferase [Ca...

232

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1QWJ

26.3%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP05595
(show subtarget assignments)

1

soluble

No

BA_3346

30257889

putative 6-aminohexanoate-dimer hydrolas...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WYB

26.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP01708
(show subtarget assignments)

1

expressed

No

Cj0241c

15791613

putative iron-binding protein [Campyloba...

133

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AVK

26.3%

Campylobacter jejuni

Cellular processes

Other

IDP02399
(show subtarget assignments)

1

cloned

No

GBAA2559

47527848

D-alanyl-D-alanine carboxypeptidase fami...

338

Drug target motif; Drug target functions

Phase 3: June 2008

1XP4

26.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02335
(show subtarget assignments)

1

expressed

No

GBAA2583

47527873

hypothetical protein GBAA2583 [Bacillus ...

563

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3SKS

26.3%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP91987
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100008765

298255669

ABC transporter substrate-binding protei...

335

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3IX1

26.3%

Streptococcus pneumoniae

IDP04730
(show subtarget assignments)

1

cloned

No

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP04537
(show subtarget assignments)

8

selected

No

CAC05780

12329049

virF

VirF, member of the AraC family of trans...

262

Shigella effector protein

Community Requests

3GBG

26.3%

Shigella flexneri

IDP01144
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP05050
(show subtarget assignments)

1

purified

No

BA_5330

30259806

iron compound ABC transporter, iron comp...

333

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GFV

26.4%

Bacillus anthracis

Transport and binding proteins: Cations and iron carrying compounds

IDP05631
(show subtarget assignments)

1

crystallized

No

CD1979

126699588

ABC transporter, substrate-binding prote...

337

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

26.4%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP02210
(show subtarget assignments)

1

cloned

No

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP01628
(show subtarget assignments)

1

cloned

No

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP05137
(show subtarget assignments)

1

soluble

No

CD0227

126697798

hypothetical protein CD0227 [Clostridium...

142

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2QUP

26.4%

Clostridium difficile

Hypothetical proteins: Conserved

IDP05444
(show subtarget assignments)

1

soluble

No

lmo0768

16802810

-

hypothetical protein lmo0768 [Listeria m...

417

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

26.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP04110
(show subtarget assignments)

1

expressed

No

YPO2440

218929529

yfeB

ATP-binding transport protein [Yersinia ...

296

virulence factor; conserved gene;

Phase 4: April 2009

3GFO

26.4%

Yersinia pestis

Unknown function

General

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04140
(show subtarget assignments)

1

cloned

No

YPO3116

115348760

ascD

cdp-6-deoxy-delta-3,4-glucoseen reductas...

329

virulence factor; putative drug target function;

Phase 4: April 2009

1KRH

26.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05744
(show subtarget assignments)

1

cloned

No

CD2744

126700359

relA

putative GTP pyrophosphokinase [Clostrid...

735

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VJ7

26.4%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01206
(show subtarget assignments)

1

purified

No

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04675
(show subtarget assignments)

1

soluble

No

GBAA2291

47527591

sensor histidine kinase [Bacillus anthra...

377

putative drug target function;

Phase 4: April 2009

3A0R

26.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91816
(show subtarget assignments)

8

cloned

No

b2463

1788806

maeB

fused malic enzyme predicted oxidoreduct...

759

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1WW8

26.5%

Escherichia coli

IDP02588
(show subtarget assignments)

6

cloned

No

AAC67800

3328615

gseA

KDO Transferase [Chlamydia trachomatis D...

431

KdtA is responsible for the formation of the genus-specific lipopolysaccharide e...

Phase 3: June 2008

2XCI

26.5%

Chlamydia trachomatis

N/A

IDP02805
(show subtarget assignments)

1

expressed

No

Cj1129c

15792454

wlaC

general glycosylation pathway protein [C...

359

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3L01

26.5%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02224
(show subtarget assignments)

1

cloned

No

YPO0616

16120942

putative glycosyl hydrolase [Yersinia pe...

727

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

2X40

26.5%

Yersinia pestis

Energy metabolism

Sugars

IDP01924
(show subtarget assignments)

1

purified

No

lmo0692

16802734

cheA

two-component sensor histidine kinase Ch...

618

Known virulence-Regulation; PMID:15155625

Phase 3: June 2008

1B3Q

26.5%

Listeria monocytogenes

Cellular processes

Chemotaxis and motility

IDP04447
(show subtarget assignments)

1

expressed

No

YPO0690

218927881

putative type II secretion protein [Yers...

428

putative drug target function;

Phase 4: April 2009

2OAP

26.6%

Yersinia pestis

Cell envelope

Surface structures

IDP00346
(show subtarget assignments)

1

cloned

No

lmo0489

16802532

hypothetical protein lmo0489

664

Drug Target Function

Phase 2: March 2008

3K30

26.6%

Listeria monocytogenes

Energy metabolism

Electron transport

IDP05361
(show subtarget assignments)

1

cloned

No

BA_1162

30254880

alpha-amylase family protein [Bacillus a...

433

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1CYG

26.7%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05120
(show subtarget assignments)

1

in_crystallization_trials

No

CD0236

126697807

fliS2

flagellar protein [Clostridium difficile...

116

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VH6

26.7%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00962
(show subtarget assignments)

1

cloned

No

STM1427

16764775

cfa

cyclopropane fatty acyl phospholipid syn...

382

Drug Target Function

Phase 2: March 2008

1KP9

26.7%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02276
(show subtarget assignments)

1

expressed

No

YPO0860

16121168

sugar-binding periplasmic protein [Yersi...

333

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

26.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02300
(show subtarget assignments)

1

soluble

No

GBAA1860

47527151

alpha/beta fold family hydrolase [Bacill...

307

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3HJU

26.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP00822
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2253

57285032

femX

femX protein

421

Conserved Gene / Pathway

Phase 2: March 2008

1LRZ

26.7%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05164
(show subtarget assignments)

1

purified

No

BA_1735

30256021

putative ABC transporter, substrate-bind...

341

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EDP

26.7%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP91183
(show subtarget assignments)

8

in_pdb
3T7Y

No

CT091

15604810

yscU

type III secretion system protein [Chlam...

360

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

3T7Y

26.7%

Chlamydia trachomatis

IDP05566
(show subtarget assignments)

1

soluble

No

lmo2569

16804607

-

hypothetical protein lmo2569 [Listeria m...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3O9P

26.7%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Plasmid functions

IDP91963
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100009553

298255821

branched-chain amino acid ABC transporte...

386

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3TD9

26.7%

Streptococcus pneumoniae

IDP01770
(show subtarget assignments)

1

expressed

No

Cj1447c

15792764

kpsT

capsular polysaccharide ABC transporter,...

220

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2BBS

26.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02802
(show subtarget assignments)

1

cloned

No

GBAA3471

47528757

short chain dehydrogenase/reductase fami...

234

Conserved; Essential;

Phase 3: June 2008

1SNY

26.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP90249
(show subtarget assignments)

8

soluble

No

VC2645

15642640

acetylornithine deacetylase [Vibrio chol...

378

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

26.8%

Vibrio cholerae

IDP00711
(show subtarget assignments)

1

soluble

No

SACOL0997

57284371

oligopeptide ABC transporter, ATP-bindin...

328

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

26.8%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP02291
(show subtarget assignments)

1

cloned

No

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01146
(show subtarget assignments)

1

cloned

No

BA_0235

30253735

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

26.8%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP04693
(show subtarget assignments)

1

cloned

No

GBAA5598

47530920

sensor histidine kinase [Bacillus anthra...

376

drug target; putative drug target function;

Phase 4: April 2009

3GIG

26.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91276
(show subtarget assignments)

8

soluble

No

NT05BA4392

49181134

ribosomal protein L11 methyltransferase ...

312

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3GRZ

26.9%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90206
(show subtarget assignments)

8

soluble

No

MYXV_gp149

9633781

m146R

108

virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L

Community Requests

2I39

26.9%

Myxoma virus

host defense modulator

0

IDP04687
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90250
(show subtarget assignments)

8

expressed

No

Z5515

15804553

argE

acetylornithine deacetylase [Escherichia...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3IC1

26.9%

Escherichia coli

IDP90248
(show subtarget assignments)

8

purified

No

BAS0467

49183495

acetylornithine deacetylase [Bacillus an...

426

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3PFO

27%

Bacillus anthracis

IDP02158
(show subtarget assignments)

1

cloned

No

Cj1617

15792922

chuD

putative haemin uptake system periplasmi...

268

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3GFV

27%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP91091
(show subtarget assignments)

8

cloned

No

APL_0387

126096663

kpsF

arabinose-5-phosphate isomerase [Actinob...

311

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

27%

Actinobacillus pleuropneumoniae

IDP00332
(show subtarget assignments)

1

purified

No

FTT1673

56708683

ribA

riboflavin biosynthesis protein ribA/GTP...

403

Drug Target Function

Phase 2: March 2008

1G57

27%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05369
(show subtarget assignments)

1

soluble

No

BA_4597

30259097

iron compound ABC transporter, iron comp...

315

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2PHZ

27%

Bacillus anthracis

Transport and binding proteins: Cations and iron carrying compounds

IDP91242
(show subtarget assignments)

8

cloned

No

HP0773

2313904

predicted coding region HP0773 [Helicoba...

363

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3BO9

27%

Helicobacter pylori

IDP00017
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4333

81581445

ribBA

Riboflavin biosynthesis protein ribBA [I...

397

Drug Target Homolog

Phase 1: October 2007

2BZ0

27%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP92037
(show subtarget assignments)

8

selected

No

TGME49_033820

237837865

DNA polymerase delta small subunit, puta...

492

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3E0J

27%

Toxoplasma gondii

IDP01120
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP91705
(show subtarget assignments)

8

selected

No

NP_004879

4757818

ATP6V1G1

V-type proton ATPase subunit G 1 [Homo s...

118

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2K88

27.1%

Homo sapiens

IDP00313
(show subtarget assignments)

1

expressed

No

CBU_0647

29653985

ribA

riboflavin biosynthesis protein RibA

406

Drug Target Function

Phase 2: March 2008

2BZ0

27.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90274
(show subtarget assignments)

8

selected

No

TGME49_015260

211968509

carbamoyl phosphate synthetase II [Toxop...

1699

Mutation of the rate-limiting enzyme carbamoyl phosphate synthetase II (CPSII) d...

Community Requests

1A9X

27.1%

Toxoplasma gondii

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00101
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF2638

30041803

mrp

putative ATPase

369

Essential

Phase 1: October 2007

2PH1

27.1%

Shigella flexneri

Unknown function

General

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05526
(show subtarget assignments)

1

soluble

No

CD1319

126698918

putative polysaccharide deacetylase [Clo...

247

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J13

27.1%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00718
(show subtarget assignments)

1

soluble

No

SACOL1434

57286085

alanine racemase family protein

361

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

27.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91612
(show subtarget assignments)

8

purified

No

BAB36911

13362959

ECs3488

hypothetical protein [Escherichia coli O...

140

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

27.1%

Escherichia coli

IDP02529
(show subtarget assignments)

1

cloned

No

Cj0003

15791402

gyrB

DNA gyrase subunit B [Campylobacter jeju...

769

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1EI1

27.2%

Campylobacter jejuni

Cell envelope

Other

IDP05652
(show subtarget assignments)

1

cloned

No

lmo0129

16802177

-

hypothetical protein lmo0129 [Listeria m...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3NE8

27.2%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00109
(show subtarget assignments)

1

in_crystallization_trials

No

NT01SF4517

30043269

recF

Rec protein

357

Essential

Phase 1: October 2007

2O5V

27.2%

Shigella flexneri

DNA metabolism

DNA replication, recombination, and repair

IDP90641
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0099

15791487

birA

biotin--protein ligase [Campylobacter je...

217

Predicted Essential

Community Requests

2EAY

27.2%

Campylobacter jejuni