Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00579 (show subtarget assignments)	1	cloned	No	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02717 (show subtarget assignments)	1	cloned	No	GBAA3854	47529142	chi36	extracellular exochitinase Chi36 [Bacill...	360	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N11	88.6%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01111 (show subtarget assignments)	1	cloned	No	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01845 (show subtarget assignments)	1	cloned	No	STM0017	16763407		hypothetical protein STM0017 [Salmonella...	147	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP02227 (show subtarget assignments)	1	cloned	No	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02720 (show subtarget assignments)	1	cloned	No	GBAA3950	47529240	infB	translation initiation factor IF-2 [Baci...	686	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1ZO1	42%	Bacillus anthracis	Protein synthesis	Translation factors

IDP01385 (show subtarget assignments)	1	cloned	No	VC0560	15640582		signal recognition particle protein	461	Drug Target Function	Phase 2: March 2008	2XXA	73.1%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01853 (show subtarget assignments)	1	cloned	No	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP02234 (show subtarget assignments)	1	cloned	No	FTT1094c	56708177		cytosol aminopeptidase family protein [F...	471	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IJ3	41.1%	Francisella tularensis	N/A	N/A

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02061 (show subtarget assignments)	1	cloned	No	CBU_0147	29540767	secA	preprotein translocase, SecA subunit [Co...	913	Conserved; Drug target functions	Phase 3: June 2008	2FSF	59.9%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP05054 (show subtarget assignments)	1	cloned	No	CD0250	126697821	fliH	flagellar assembly protein [Clostridium ...	243	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00275 (show subtarget assignments)	1	cloned	No	NP_056776_776-1127	159024209	N/A	NS1	352	Secreted from infected cells; stimulates protective immune responses (reason for...	Phase 3: June 2008			Dengue virus	host defense modulator	N/A

IDP01852 (show subtarget assignments)	1	cloned	No	GBAA5449	47530763	celA-3	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00587 (show subtarget assignments)	1	cloned	No	YPO1507	16121780	mglB	galactose-binding protein	335	Virulence Associated Factor	Phase 2: March 2008	1GCA	80.9%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP05066 (show subtarget assignments)	1	cloned	No	CD2654	126700268	mraY	phospho-N-acetylmuramoyl-pentapeptide-tr...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01851 (show subtarget assignments)	1	cloned	No	GBAA5427	47778402		endopeptidase lytE, putative [Bacillus a...	436	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H41	9.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP04365 (show subtarget assignments)	1	cloned	No	CPF_1523	110798905		sensory box histidine kinase [Clostridiu...	787	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	11.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04348 (show subtarget assignments)	1	cloned	No	CPF_2547	110801206		two component regulator [Clostridium per...	686	viruelnce factor;	Phase 4: April 2009			Clostridium perfringens	Unknown function	General

IDP00849 (show subtarget assignments)	1	cloned	No	SACOL2326	57285061	fosB	fosfomycin resistance protein FosB	139	Conserved Gene / Pathway	Phase 2: March 2008	3UH9	64.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04350 (show subtarget assignments)	1	cloned	No	STM1338_1_795	16764689	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Salmonella essential protein	Phase 4: April 2009	3PCO	92.6%	Salmonella enterica

IDP02051 (show subtarget assignments)	1	cloned	No	STM4141	16767399		putative cytoplasmic protein [Salmonella...	57	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP04351 (show subtarget assignments)	1	cloned	No	CPF_1213	110799898	kdpD	sensor histidine kinase KdpD [Clostridiu...	900	conserved gene; putative drug target function;	Phase 4: April 2009	2R8R	12.7%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP00846 (show subtarget assignments)	1	cloned	No	SACOL1177	57284462		hypothetical protein SACOL1177	43	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP04338 (show subtarget assignments)	1	cloned	No	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP04340 (show subtarget assignments)	1	cloned	No	BAS0122	49183156		50S ribosomal protein L5 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1IQ4	85.5%	Bacillus anthracis

IDP00450 (show subtarget assignments)	1	cloned	No	YPCD1.40	16082728	yscN	type III secretion system ATPase	439	Virulence Associated Factor	Phase 2: March 2008	2DPY	42.8%	Yersinia pestis	Energy metabolism	ATP-proton motive force interconversion

IDP00843 (show subtarget assignments)	1	cloned	No	SACOL1859	57284780		hypothetical protein SACOL1859	1016	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP02479 (show subtarget assignments)	1	cloned	No	lmo1287	16803327	parC	DNA topoisomerase IV subunit A [Listeria...	819	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	2INR	41.8%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP04342 (show subtarget assignments)	1	cloned	No	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04356 (show subtarget assignments)	1	cloned	No	YPO0509	115346318		hypothetical protein [Yersinia pestis CO...	540	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2XT4	9.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02042 (show subtarget assignments)	1	cloned	No	CBU_0875	29541467	asd	aspartate-semialdehyde dehydrogenase [Co...	340	Conserved; Drug target functions	Phase 3: June 2008	2QZ9	61.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00449 (show subtarget assignments)	1	cloned	No	YPO2706	16122910	yplA	phospholipase A	320	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04333 (show subtarget assignments)	1	cloned	No	VC2483	9657062		acetolactate synthase III, large subunit...	573	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	42.8%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02480 (show subtarget assignments)	1	cloned	No	GBAA5700	47531036	galE-2	UDP-glucose 4-epimerase [Bacillus anthra...	338	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3ENK	58.6%	Bacillus anthracis	Energy metabolism	Sugars

IDP02491 (show subtarget assignments)	1	cloned	No	YPO1811	16122063		short chain dehydrogenase [Yersinia pest...	688	Conserved; CD; Drug target functions	Phase 3: June 2008	3U0B	14.8%	Yersinia pestis	Central intermediary metabolism	Other

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00447 (show subtarget assignments)	1	cloned	No	YPCD1.71c	16082759	yopJ	targeted effector protein	288	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP01732 (show subtarget assignments)	1	cloned	No	STM1243	16764598		cold shock-like protein [Salmonella typh...	70	Conserved; Drug target functions	Phase 3: June 2008	2L15	48.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02045 (show subtarget assignments)	1	cloned	No	FTT0749c	56707864		hypothetical protein FTT0749c [Francisel...	328	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AIM	25.6%	Francisella tularensis	Central intermediary metabolism	Other

IDP00023 (show subtarget assignments)	1	cloned	No	BA_5594	30260051	papR	PapR	48	Drug Target Homolog	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Pathogenesis

IDP02052 (show subtarget assignments)	1	cloned	No	YPO2924	16123111		hypothetical protein YPO2924 [Yersinia p...	215	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP04337 (show subtarget assignments)	1	cloned	No	CPF_0720	110801161	splB	spore photoproduct lyase [Clostridium pe...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04358 (show subtarget assignments)	1	cloned	No	YPO0895	115346679	creC	putative histidine kinase sensor [Yersin...	472	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.8%	Yersinia pestis	Regulatory functions	Other

IDP04393 (show subtarget assignments)	1	cloned	No	CPF_1645	110798596	lonB	ATP-dependent protease LonB [Clostridium...	570	conserved gene; putative drug target function;	Phase 4: April 2009	3K1J	29.4%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00185 (show subtarget assignments)	1	cloned	No	YPO0639	16120963	-	hypothetical protein	460	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP00833 (show subtarget assignments)	1	cloned	No	SACOL2627	57286532	betA	choline dehydrogenase	569	Conserved Gene / Pathway	Phase 2: March 2008	3LJP	32.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02033 (show subtarget assignments)	1	cloned	No	Cj1135	15792460		glycosyltransferase [Campylobacter jejun...	515	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2Z86	14%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00444 (show subtarget assignments)	1	cloned	No	YPO0342	16120677		putative oxidoreductase Fe-S binding sub...	671	Drug Target Function	Phase 2: March 2008	2VDC	28.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP02034 (show subtarget assignments)	1	cloned	No	lmo0059	16802107		hypothetical protein lmo0059 [Listeria m...	83	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008	2BPS	27.7%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP04322 (show subtarget assignments)	1	cloned	No	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02031 (show subtarget assignments)	1	cloned	No	lmo2504	16804542		hypothetical protein lmo2504 [Listeria m...	436	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2GU1	17.2%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01718 (show subtarget assignments)	1	cloned	No	YPO3473	16123619		hypothetical protein YPO3473 [Yersinia p...	408	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3NFV	30.9%	Yersinia pestis	Cell envelope	Other

IDP02035 (show subtarget assignments)	1	cloned	No	Cj1141	15792466	neuB1	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1XUU	59%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02469 (show subtarget assignments)	1	cloned	No	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00184 (show subtarget assignments)	1	cloned	No	YPO0624	16120950	-	putative membrane protein	483	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP04317 (show subtarget assignments)	1	cloned	No	YPO0512	218927711		putative lipoprotein [Yersinia pestis CO...	163	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP01720 (show subtarget assignments)	1	cloned	No	Cj1128c	15792453	wlaD	general glycosylation pathway protein [C...	309	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	3BCV	16.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00824 (show subtarget assignments)	1	cloned	No	SACOL2418	57285148		IgG-binding protein SBI	436	Conserved Gene / Pathway	Phase 2: March 2008	2WY7	16.1%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP04308 (show subtarget assignments)	1	cloned	No	YPCD1.14n	40548797		hypothetical protein YPCD1.14n [Yersinia...	65	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP01714 (show subtarget assignments)	1	cloned	No	Cj0528c	15791889	flgB	flagellar basal body rod protein FlgB [C...	143	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP00183 (show subtarget assignments)	1	cloned	No	YPO0613	16120939	-	putative permease protein	293	Virulence	Phase 1: October 2007	2R6G	22.5%	Yersinia pestis

IDP01716 (show subtarget assignments)	1	cloned	No	Cj0687c	15792036	flgH	flagellar basal body L-ring protein [Cam...	232	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP02468 (show subtarget assignments)	1	cloned	No	Cj0914c	15792243		invasion antigen B [Campylobacter jejuni...	610	Known Predicted virulence-invasion; PMID:10339609	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02474 (show subtarget assignments)	1	cloned	No	Cj0922c	15792251	pebC	amino acid ABC transporter ATP-binding p...	242	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	2OLJ	52.5%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02036 (show subtarget assignments)	1	cloned	No	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01717 (show subtarget assignments)	1	cloned	No	Cj0968	15792296		putative periplasmic protein [Campylobac...	80	Predicted virulence-Adhesion of Campylobacter; Possible Vaccine Candidate	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP02025 (show subtarget assignments)	1	cloned	No	lmo0394	16802439		hypothetical protein lmo0394 [Listeria m...	227	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2XIV	19.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP02460 (show subtarget assignments)	1	cloned	No	YPO1675	16121939	cheD	methyl-accepting chemotaxis protein [Yer...	557	CD; Drug target functions	Phase 3: June 2008	3ZX6	43.3%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00436 (show subtarget assignments)	1	cloned	No	YPO3358	16123508	surE	stationary phase survival protein SurE	254	Conserved Gene / Pathway	Phase 2: March 2008	2V4N	79.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP04304 (show subtarget assignments)	1	cloned	No	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP00810 (show subtarget assignments)	1	cloned	No	SACOL1870	57284791		hypothetical protein SACOL1870	188	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	0	0

IDP00809 (show subtarget assignments)	1	cloned	No	SACOL1869	57284790	splA	serine protease SplA	238	Drug Target Function	Phase 2: March 2008	2W7S	84%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01706 (show subtarget assignments)	1	cloned	No	STM1438	16764786	ydhL	putative oxidoreductase [Salmonella typh...	79	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP00808 (show subtarget assignments)	1	cloned	No	SACOL1868	57284789	splB	serine protease SplB	240	Drug Target Function	Phase 2: March 2008	2VID	85%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00806 (show subtarget assignments)	1	cloned	No	SACOL1861	57284782	hsdS	type I restriction-modification enzyme, ...	399	Drug Target Function	Phase 2: March 2008	1YF2	27.8%	Staphylococcus aureus	DNA metabolism	Restriction/modification

IDP00434 (show subtarget assignments)	1	cloned	No	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00579
(show subtarget assignments)

1

cloned

No

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02717
(show subtarget assignments)

1

cloned

No

GBAA3854

47529142

chi36

extracellular exochitinase Chi36 [Bacill...

360

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N11

88.6%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01111
(show subtarget assignments)

1

cloned

No

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01845
(show subtarget assignments)

1

cloned

No

STM0017

16763407

hypothetical protein STM0017 [Salmonella...

147

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02227
(show subtarget assignments)

1

cloned

No

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02720
(show subtarget assignments)

1

cloned

No

GBAA3950

47529240

infB

translation initiation factor IF-2 [Baci...

686

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1ZO1

42%

Bacillus anthracis

Protein synthesis

Translation factors

IDP01385
(show subtarget assignments)

1

cloned

No

VC0560

15640582

signal recognition particle protein

461

Drug Target Function

Phase 2: March 2008

2XXA

73.1%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01853
(show subtarget assignments)

1

cloned

No

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP02234
(show subtarget assignments)

1

cloned

No

FTT1094c

56708177

cytosol aminopeptidase family protein [F...

471

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IJ3

41.1%

Francisella tularensis

N/A

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02061
(show subtarget assignments)

1

cloned

No

CBU_0147

29540767

secA

preprotein translocase, SecA subunit [Co...

913

Conserved; Drug target functions

Phase 3: June 2008

2FSF

59.9%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP05054
(show subtarget assignments)

1

cloned

No

CD0250

126697821

fliH

flagellar assembly protein [Clostridium ...

243

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00275
(show subtarget assignments)

1

cloned

No

NP_056776_776-1127

159024209

N/A

NS1

352

Secreted from infected cells; stimulates protective immune responses (reason for...

Phase 3: June 2008

Dengue virus

host defense modulator

N/A

IDP01852
(show subtarget assignments)

1

cloned

No

GBAA5449

47530763

celA-3

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00587
(show subtarget assignments)

1

cloned

No

YPO1507

16121780

mglB

galactose-binding protein

335

Virulence Associated Factor

Phase 2: March 2008

1GCA

80.9%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP05066
(show subtarget assignments)

1

cloned

No

CD2654

126700268

mraY

phospho-N-acetylmuramoyl-pentapeptide-tr...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01851
(show subtarget assignments)

1

cloned

No

GBAA5427

47778402

endopeptidase lytE, putative [Bacillus a...

436

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H41

9.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP04365
(show subtarget assignments)

1

cloned

No

CPF_1523

110798905

sensory box histidine kinase [Clostridiu...

787

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

11.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04348
(show subtarget assignments)

1

cloned

No

CPF_2547

110801206

two component regulator [Clostridium per...

686

viruelnce factor;

Phase 4: April 2009

Clostridium perfringens

Unknown function

General

IDP00849
(show subtarget assignments)

1

cloned

No

SACOL2326

57285061

fosB

fosfomycin resistance protein FosB

139

Conserved Gene / Pathway

Phase 2: March 2008

3UH9

64.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04350
(show subtarget assignments)

1

cloned

No

STM1338_1_795

16764689

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Salmonella essential protein

Phase 4: April 2009

3PCO

92.6%

Salmonella enterica

IDP02051
(show subtarget assignments)

1

cloned

No

STM4141

16767399

putative cytoplasmic protein [Salmonella...

57

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP04351
(show subtarget assignments)

1

cloned

No

CPF_1213

110799898

kdpD

sensor histidine kinase KdpD [Clostridiu...

900

conserved gene; putative drug target function;

Phase 4: April 2009

2R8R

12.7%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP00846
(show subtarget assignments)

1

cloned

No

SACOL1177

57284462

hypothetical protein SACOL1177

43

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

0

IDP04338
(show subtarget assignments)

1

cloned

No

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP04340
(show subtarget assignments)

1

cloned

No

BAS0122

49183156

50S ribosomal protein L5 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1IQ4

85.5%

Bacillus anthracis

IDP00450
(show subtarget assignments)

1

cloned

No

YPCD1.40

16082728

yscN

type III secretion system ATPase

439

Virulence Associated Factor

Phase 2: March 2008

2DPY

42.8%

Yersinia pestis

Energy metabolism

ATP-proton motive force interconversion

IDP00843
(show subtarget assignments)

1

cloned

No

SACOL1859

57284780

hypothetical protein SACOL1859

1016

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

0

IDP02479
(show subtarget assignments)

1

cloned

No

lmo1287

16803327

parC

DNA topoisomerase IV subunit A [Listeria...

819

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

2INR

41.8%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP04342
(show subtarget assignments)

1

cloned

No

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04356
(show subtarget assignments)

1

cloned

No

YPO0509

115346318

hypothetical protein [Yersinia pestis CO...

540

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2XT4

9.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02042
(show subtarget assignments)

1

cloned

No

CBU_0875

29541467

asd

aspartate-semialdehyde dehydrogenase [Co...

340

Conserved; Drug target functions

Phase 3: June 2008

2QZ9

61.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00449
(show subtarget assignments)

1

cloned

No

YPO2706

16122910

yplA

phospholipase A

320

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04333
(show subtarget assignments)

1

cloned

No

VC2483

9657062

acetolactate synthase III, large subunit...

573

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

42.8%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02480
(show subtarget assignments)

1

cloned

No

GBAA5700

47531036

galE-2

UDP-glucose 4-epimerase [Bacillus anthra...

338

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3ENK

58.6%

Bacillus anthracis

Energy metabolism

Sugars

IDP02491
(show subtarget assignments)

1

cloned

No

YPO1811

16122063

short chain dehydrogenase [Yersinia pest...

688

Conserved; CD; Drug target functions

Phase 3: June 2008

3U0B

14.8%

Yersinia pestis

Central intermediary metabolism

Other

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00447
(show subtarget assignments)

1

cloned

No

YPCD1.71c

16082759

yopJ

targeted effector protein

288

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP01732
(show subtarget assignments)

1

cloned

No

STM1243

16764598

cold shock-like protein [Salmonella typh...

70

Conserved; Drug target functions

Phase 3: June 2008

2L15

48.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02045
(show subtarget assignments)

1

cloned

No

FTT0749c

56707864

hypothetical protein FTT0749c [Francisel...

328

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AIM

25.6%

Francisella tularensis

Central intermediary metabolism

Other

IDP00023
(show subtarget assignments)

1

cloned

No

BA_5594

30260051

papR

PapR

48

Drug Target Homolog

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Pathogenesis

IDP02052
(show subtarget assignments)

1

cloned

No

YPO2924

16123111

hypothetical protein YPO2924 [Yersinia p...

215

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP04337
(show subtarget assignments)

1

cloned

No

CPF_0720

110801161

splB

spore photoproduct lyase [Clostridium pe...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04358
(show subtarget assignments)

1

cloned

No

YPO0895

115346679

creC

putative histidine kinase sensor [Yersin...

472

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.8%

Yersinia pestis

Regulatory functions

Other

IDP04393
(show subtarget assignments)

1

cloned

No

CPF_1645

110798596

lonB

ATP-dependent protease LonB [Clostridium...

570

conserved gene; putative drug target function;

Phase 4: April 2009

3K1J

29.4%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00185
(show subtarget assignments)

1

cloned

No

YPO0639

16120963

-

hypothetical protein

460

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP00833
(show subtarget assignments)

1

cloned

No

SACOL2627

57286532

betA

choline dehydrogenase

569

Conserved Gene / Pathway

Phase 2: March 2008

3LJP

32.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02033
(show subtarget assignments)

1

cloned

No

Cj1135

15792460

glycosyltransferase [Campylobacter jejun...

515

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2Z86

14%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00444
(show subtarget assignments)

1

cloned

No

YPO0342

16120677

putative oxidoreductase Fe-S binding sub...

671

Drug Target Function

Phase 2: March 2008

2VDC

28.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP02034
(show subtarget assignments)

1

cloned

No

lmo0059

16802107

hypothetical protein lmo0059 [Listeria m...

83

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

2BPS

27.7%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP04322
(show subtarget assignments)

1

cloned

No

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02031
(show subtarget assignments)

1

cloned

No

lmo2504

16804542

hypothetical protein lmo2504 [Listeria m...

436

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2GU1

17.2%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01718
(show subtarget assignments)

1

cloned

No

YPO3473

16123619

hypothetical protein YPO3473 [Yersinia p...

408

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3NFV

30.9%

Yersinia pestis

Cell envelope

Other

IDP02035
(show subtarget assignments)

1

cloned

No

Cj1141

15792466

neuB1

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1XUU

59%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02469
(show subtarget assignments)

1

cloned

No

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00184
(show subtarget assignments)

1

cloned

No

YPO0624

16120950

-

putative membrane protein

483

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP04317
(show subtarget assignments)

1

cloned

No

YPO0512

218927711

putative lipoprotein [Yersinia pestis CO...

163

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP01720
(show subtarget assignments)

1

cloned

No

Cj1128c

15792453

wlaD

general glycosylation pathway protein [C...

309

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

3BCV

16.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00824
(show subtarget assignments)

1

cloned

No

SACOL2418

57285148

IgG-binding protein SBI

436

Conserved Gene / Pathway

Phase 2: March 2008

2WY7

16.1%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP04308
(show subtarget assignments)

1

cloned

No

YPCD1.14n

40548797

hypothetical protein YPCD1.14n [Yersinia...

65

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP01714
(show subtarget assignments)

1

cloned

No

Cj0528c

15791889

flgB

flagellar basal body rod protein FlgB [C...

143

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP00183
(show subtarget assignments)

1

cloned

No

YPO0613

16120939

-

putative permease protein

293

Virulence

Phase 1: October 2007

2R6G

22.5%

Yersinia pestis

IDP01716
(show subtarget assignments)

1

cloned

No

Cj0687c

15792036

flgH

flagellar basal body L-ring protein [Cam...

232

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP02468
(show subtarget assignments)

1

cloned

No

Cj0914c

15792243

invasion antigen B [Campylobacter jejuni...

610

Known Predicted virulence-invasion; PMID:10339609

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02474
(show subtarget assignments)

1

cloned

No

Cj0922c

15792251

pebC

amino acid ABC transporter ATP-binding p...

242

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

2OLJ

52.5%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02036
(show subtarget assignments)

1

cloned

No

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01717
(show subtarget assignments)

1

cloned

No

Cj0968

15792296

putative periplasmic protein [Campylobac...

80

Predicted virulence-Adhesion of Campylobacter; Possible Vaccine Candidate

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP02025
(show subtarget assignments)

1

cloned

No

lmo0394

16802439

hypothetical protein lmo0394 [Listeria m...

227

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2XIV

19.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP02460
(show subtarget assignments)

1

cloned

No

YPO1675

16121939

cheD

methyl-accepting chemotaxis protein [Yer...

557

CD; Drug target functions

Phase 3: June 2008

3ZX6

43.3%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00436
(show subtarget assignments)

1

cloned

No

YPO3358

16123508

surE

stationary phase survival protein SurE

254

Conserved Gene / Pathway

Phase 2: March 2008

2V4N

79.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP04304
(show subtarget assignments)

1

cloned

No

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP00810
(show subtarget assignments)

1

cloned

No

SACOL1870

57284791

hypothetical protein SACOL1870

188

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

0

IDP00809
(show subtarget assignments)

1

cloned

No

SACOL1869

57284790

splA

serine protease SplA

238

Drug Target Function

Phase 2: March 2008

2W7S

84%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01706
(show subtarget assignments)

1

cloned

No

STM1438

16764786

ydhL

putative oxidoreductase [Salmonella typh...

79

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP00808
(show subtarget assignments)

1

cloned

No

SACOL1868

57284789

splB

serine protease SplB

240

Drug Target Function

Phase 2: March 2008

2VID

85%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00806
(show subtarget assignments)

1

cloned

No

SACOL1861

57284782

hsdS

type I restriction-modification enzyme, ...

399

Drug Target Function

Phase 2: March 2008

1YF2

27.8%

Staphylococcus aureus

DNA metabolism

Restriction/modification

IDP00434
(show subtarget assignments)

1

cloned

No

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family