(skip to main content)
Home
Target List
Selection
Community Requests
Clones
Screenings
XML files
Diffraction Images
Progress
Homolog Search
Clustering
Statistics
News
Help
Log In
Consortium
Overview
Investigators
Experiments
X-ray Structures
NMR Structures
Electronic Structure Description
Publications
Resources
Clustering
Related Sites
Progress
Collaborators
Basecamp
Contact Us
Log In
Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
In
IDP#
NCBI GI
LOCUS TAG
Search
Page 11 of 60, showing 100 records out of 5973 total, starting on record 1001
previous
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
next
CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91510
(
show subtarget assignments
)
8
cloned
No
VP1664
28898438
putative type III secretion protein [Vib...
126
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP04708
(
show subtarget assignments
)
1
purified
No
BAS0114
49183148
30S ribosomal protein S19 [Bacillus anth...
92
Proposed to be essential proteins
Phase 4: April 2009
1FJG
66.3%
Bacillus anthracis
IDP91514
(
show subtarget assignments
)
8
expressed
No
VV2_1517
27367864
agglutination protein [Vibrio vulnificus...
436
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YC9
16.5%
Vibrio vulnificus
IDP91513
(
show subtarget assignments
)
8
expressed
No
VV2_1516
27367863
HlyD family secretion protein [Vibrio vu...
442
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91512
(
show subtarget assignments
)
8
cloned
No
VV2_0404
27366843
cytolysin [Vibrio vulnificus CMCP6]
468
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XEZ
25.9%
Vibrio vulnificus
IDP91578
(
show subtarget assignments
)
8
cloned
No
BAB37984
13364036
ECs4561
translocated intimin receptor Tir [Esche...
558
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2ZQK
12.2%
Escherichia coli
IDP04098
(
show subtarget assignments
)
1
cloned
No
YPCD1.50
5832470
YPCD1.50
hypothetical protein YPCD1.50 [Yersinia ...
32
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05581
(
show subtarget assignments
)
1
cloned
No
BA_1407
30255341
hypothetical protein BA_1407 [Bacillus a...
51
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91072
(
show subtarget assignments
)
8
cloned
No
YPO2588
16122801
-
putative ABC transport protein
631
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
32.2%
Yersinia pestis
IDP04731
(
show subtarget assignments
)
1
crystallized
No
BAS3675
49186674
ribosome recycling factor [Bacillus anth...
185
Proposed to be essential proteins
Phase 4: April 2009
1IS1
50.8%
Bacillus anthracis
IDP91522
(
show subtarget assignments
)
8
selected
No
TGGT1_033230
221484314
conserved hypothetical protein [Toxoplas...
610
potential drug target /
Identified in yeast two-hybrid screen with MORN1 as bait and named MIP1 for MORN...
Community Requests
Toxoplasma gondii
IDP91046
(
show subtarget assignments
)
8
in_pdb
4ECL
No
EFE0004
33355854
vanTG
serine racemase [Enterococcus faecalis]
712
drug resistance /
Putative serine racemase involved in synthesis of D-Ala-D-Ser, a component of va...
Community Requests
4ECL
52.5%
Enterococcus faecalis
IDP91073
(
show subtarget assignments
)
8
cloned
No
YPO1395
16121675
msbA
probable transport ATP-binding protein
582
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3B5W
85.2%
Yersinia pestis
IDP91521
(
show subtarget assignments
)
8
selected
No
TGME49_040910
237834825
C2 domain-containing protein [Toxoplasma...
1990
potential drug target; virulence/pathogenesis /
DOC2.1 was identified in a temperature sensitive host cell invasion/egress mutan...
Community Requests
Toxoplasma gondii
IDP04730
(
show subtarget assignments
)
1
cloned
No
BAS4284
49187280
alanyl-tRNA synthetase [Bacillus anthrac...
880
Proposed to be essential proteins
Phase 4: April 2009
1RIQ
26.3%
Bacillus anthracis
IDP91528
(
show subtarget assignments
)
8
in_crystallization_trials
No
lpg1841
52629179
com1
27 kDa outer membrane protein [Legionell...
261
virulence/pathogenesis /
Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...
Community Requests
3GYK
25.7%
Legionella pneumophila
IDP91524
(
show subtarget assignments
)
8
selected
No
TGME49_046110
237835443
hypothetical protein TGME49_046110 [Toxo...
386
potential drug target /
Paralog of MIP1 (=MORN1 Interacting Protein 1 or MIP1; GI 237838237) and MLP2 (=...
Community Requests
Toxoplasma gondii
IDP91526
(
show subtarget assignments
)
8
in_crystallization_trials
No
lpg1815
52842042
oxyR
hydrogen peroxide-inducible genes activa...
296
other biological interest /
The Legionella pneumophila OxyR is a member of the LysR family that is no longer...
Community Requests
1I6A
28.4%
Legionella pneumophila
IDP91530
(
show subtarget assignments
)
8
purified
No
VC1268
15641281
hypothetical protein VC1268 [Vibrio chol...
524
other biological interest /
We have recently established that D-amino acids are important signal molecules t...
Community Requests
Vibrio cholerae
IDP91529
(
show subtarget assignments
)
8
soluble
No
VC_1312
9655801
alanine racemase, putative [Vibrio chole...
428
other biological interest /
The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...
Community Requests
4ECL
24.8%
Vibrio cholerae
IDP91532
(
show subtarget assignments
)
8
selected
No
TC_0728
7190757
omcA
OmcA [Chlamydia muridarum Nigg]
88
vaccine candidate /
Vaccine formulation
Community Requests
Chlamydia muridarum
IDP91531
(
show subtarget assignments
)
8
soluble
No
VC1887
15641889
hypothetical protein VC1887 [Vibrio chol...
266
potential drug target /
Vc1887 was found in a knockout screen for determinants of cell shape by action o...
Community Requests
Vibrio cholerae
IDP91023
(
show subtarget assignments
)
8
cloned
No
y2980
22126857
hypothetical protein y2980 [Yersinia pes...
180
other biological interest /
-
Community Requests
Yersinia pestis
IDP05032
(
show subtarget assignments
)
1
cloned
No
BA_1198
30255151
hypothetical protein BA_1198 [Bacillus a...
47
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04588
(
show subtarget assignments
)
1
cloned
No
BAS0130
49183164
preprotein translocase subunit SecY [Bac...
433
Proposed to be essential proteins
Phase 4: April 2009
3DIN
43.8%
Bacillus anthracis
IDP04336
(
show subtarget assignments
)
8
in_crystallization_trials
No
CAC05790
12329059
ospC1
OspC1, secreted by the Mxi-Spa secretion...
470
Shigella effector protein
Community Requests
Shigella flexneri
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP05272
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo1649
16803689
-
hypothetical protein lmo1649 [Listeria m...
171
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP04335
(
show subtarget assignments
)
1
cloned
No
STM1543_1_428
16764888
putative transport protein [Salmonella t...
428
Salmonella essential protein
Phase 4: April 2009
1PW4
23.4%
Salmonella enterica
IDP91034
(
show subtarget assignments
)
8
selected
No
SDY_P055
82524461
ospC1
OspC1 [Shigella dysenteriae Sd197]
470
virulence/pathogenesis /
A cell surface protein of S. dysenteriae and putative virulence factor secreted ...
Community Requests
Shigella dysenteriae
IDP04314
(
show subtarget assignments
)
1
purified
No
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP04326
(
show subtarget assignments
)
8
purified
No
CAC05800
12329069
ipaA
IpaA, secreted by the Mxi-Spa machinery,...
633
Shigella effector protein
Community Requests
2FM8
10.7%
Shigella flexneri
IDP91082
(
show subtarget assignments
)
8
cloned
No
CPF_1776
110800219
ABC transporter, permease/ATP-binding pr...
589
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
39.2%
Clostridium perfringens
IDP91033
(
show subtarget assignments
)
8
cloned
No
SAR0023
49240405
sasH
putative 5'-nucleotidase [Staphylococcus...
786
virulence/pathogenesis /
An uncharacterized cell surface protein of staph. aureus with an anchor site for...
Community Requests
2Z1A
22.5%
Staphylococcus aureus
IDP91081
(
show subtarget assignments
)
8
cloned
No
CD2817
126700433
ABC transporter, ATP-binding/permease pr...
596
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
39.4%
Clostridium difficile
IDP91080
(
show subtarget assignments
)
8
cloned
No
Cj0803
6968244
msbA
lipid export ABC transport protein
580
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
2HYD
31.6%
Campylobacter jejuni
IDP04340
(
show subtarget assignments
)
1
cloned
No
BAS0122
49183156
50S ribosomal protein L5 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1IQ4
85.5%
Bacillus anthracis
IDP91090
(
show subtarget assignments
)
8
cloned
No
aq_1546
15606685
kpsF
polysialic acid capsule expression prote...
322
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
25.5%
Aquifex aeolicus
IDP04339
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0115
49183149
50S ribosomal protein L22 [Bacillus anth...
113
Proposed to be essential proteins
Phase 4: April 2009
1BXE
59.3%
Bacillus anthracis
IDP91056
(
show subtarget assignments
)
8
expressed
No
AAA42941
323448
viral polyprotein [Dengue virus 2]
3391
potential drug target /
A structure of the co-complex between Dengue 2 strain 16681 full length NS3 and ...
Community Requests
2J7U
15.1%
Dengue virus
IDP91091
(
show subtarget assignments
)
8
cloned
No
APL_0387
126096663
kpsF
arabinose-5-phosphate isomerase [Actinob...
311
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
27%
Actinobacillus pleuropneumoniae
IDP05603
(
show subtarget assignments
)
1
cloned
No
BA_4709
30259202
hypothetical protein BA_4709 [Bacillus a...
50
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91092
(
show subtarget assignments
)
8
soluble
No
A1S_1236
193076931
D-arabinose 5-phosphate isomerase [Acine...
325
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
32.9%
Acinetobacter baumannii
IDP91093
(
show subtarget assignments
)
0
work_stopped
No
BPSL0538
52208591
conserved hypothetical protein [Burkhold...
327
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
30.9%
Burkholderia pseudomallei
IDP91106
(
show subtarget assignments
)
8
in_pdb
3QFK
Yes
SAOUHSC_00107
88193920
hypothetical protein SAOUHSC_00107 [Stap...
511
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QFK
99.8%
Staphylococcus aureus
IDP91052
(
show subtarget assignments
)
8
in_crystallization_trials
No
PSA0001
116063829
rmtD
16S rRNA methylase [Pseudomonas aerugino...
247
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3B89
42.5%
Pseudomonas aeruginosa
IDP91095
(
show subtarget assignments
)
8
in_pdb
3POL
No
A1S_1557
193077192
3-deoxy-manno-octulosonate cytidylyltran...
253
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3POL
100%
Acinetobacter baumannii
IDP91096
(
show subtarget assignments
)
8
soluble
No
BPSL0876
52208929
kdsB
putative 3-deoxy-manno-octulosonate cyti...
278
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
3K8D
49.6%
Burkholderia pseudomallei
IDP91143
(
show subtarget assignments
)
8
in_pdb
3R2T
Yes
SAOUHSC_00393
88194188
superantigen-like protein [Staphylococcu...
232
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R2T
100%
Staphylococcus aureus
IDP91194
(
show subtarget assignments
)
8
cloned
No
BAS4090
49187088
-
Stage III sporulation protein AH
223
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
32.7%
Bacillus anthracis
IDP91163
(
show subtarget assignments
)
8
cloned
No
VC1507
15641516
phospho-2-dehydro-3-deoxyheptonate aldol...
395
potential drug target /
Shikimate pathway enzyme
Community Requests
1GG1
48.9%
Vibrio cholerae
IDP91154
(
show subtarget assignments
)
8
in_pdb
3QFG
Yes
SAOUHSC_00808
88194568
hypothetical protein SAOUHSC_00808 [Stap...
242
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QFG
93.4%
Staphylococcus aureus
IDP04357
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0894
56707995
purCD
fusion protein PurC/PurD [Francisella tu...
770
conserved gene; putative drug target function;
Phase 4: April 2009
2YRW
20.3%
Francisella tularensis
IDP91058
(
show subtarget assignments
)
8
soluble
No
FTT_0468
56707610
surA
peptidyl-prolyl cis-trans isomerase (PPI...
473
virulence/pathogenesis /
Gene encodes a SurA orthologue which has shown to be important for virulence in ...
Community Requests
1M5Y
19.5%
Francisella tularensis
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP91059
(
show subtarget assignments
)
8
soluble
No
FTT_1472c
56708512
ppiC
peptidyl-prolyl cis-trans isomerase [Fra...
92
virulence/pathogenesis /
Gene encodes a SurA orthologue which has shown to be important for virulence in ...
Community Requests
1JNS
47.8%
Francisella tularensis
IDP91170
(
show subtarget assignments
)
8
cloned
No
lmo2236
16804275
-
similar to oxidoreductase
289
potential drug target /
Shikimate pathway enzyme
Community Requests
3TNL
52.6%
Listeria monocytogenes
IDP91171
(
show subtarget assignments
)
8
expressed
No
CT_370
9087121
RecName: Full=Shikimate biosynthesis pro...
478
potential drug target /
Shikimate pathway enzyme
Community Requests
2EGG
18.2%
Chlamydia trachomatis
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP91179
(
show subtarget assignments
)
8
expressed
No
y2283
22126168
hypothetical protein y2283 [Yersinia pes...
291
other biological interest /
Other biological interest
Community Requests
2PZ0
24.7%
Yersinia pestis
IDP91543
(
show subtarget assignments
)
8
selected
No
TGME49_057080
237831315
cAMP-specific 3',5'-cyclic phosphodieste...
1691
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3ECM
6.6%
Toxoplasma gondii
IDP91545
(
show subtarget assignments
)
8
expressed
No
AAC78336
3892237
ereA2
erythromycin esterase [Providencia stuar...
408
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Providencia stuartii
IDP91183
(
show subtarget assignments
)
8
in_pdb
3T7Y
No
CT091
15604810
yscU
type III secretion system protein [Chlam...
360
virulence/pathogenesis /
Targets that are in a network of interactions with CT670 and CT671. These protei...
Community Requests
3T7Y
26.7%
Chlamydia trachomatis
IDP91387
(
show subtarget assignments
)
8
in_pdb
3VCZ
No
VV1_1463
27364847
putative translation initiation inhibito...
129
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3VCZ
100%
Vibrio vulnificus
IDP04350
(
show subtarget assignments
)
1
cloned
No
STM1338_1_795
16764689
pheT
phenylalanyl-tRNA synthetase subunit bet...
795
Salmonella essential protein
Phase 4: April 2009
3PCO
92.6%
Salmonella enterica
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP91193
(
show subtarget assignments
)
8
cloned
No
BAS4092
49187090
-
Stage III sporulation protein AF
210
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP91025
(
show subtarget assignments
)
8
in_crystallization_trials
No
y3037
22126914
modA
molybdate transporter periplasmic protei...
263
other biological interest /
-
Community Requests
3R26
63.9%
Yersinia pestis
IDP04367
(
show subtarget assignments
)
1
cloned
No
BAS3563
49186564
PTS system, fructose-specific IIABC comp...
622
Proposed to be essential proteins
Phase 4: April 2009
2R4Q
11.4%
Bacillus anthracis
IDP91540
(
show subtarget assignments
)
8
selected
No
FTN_0549
118423054
sspA
stringent starvation protein A [Francise...
210
virulence/pathogenesis /
SspA is a critical regulator of virulence gene expression in F. tularensis.
Community Requests
3LYK
31.4%
Francisella novicida
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP91621
(
show subtarget assignments
)
8
soluble
No
BAB35649
13361692
ECs2226
hypothetical protein [Escherichia coli O...
123
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
35%
Escherichia coli
IDP05242
(
show subtarget assignments
)
1
cloned
No
lmo2079
16804118
-
hypothetical protein lmo2079 [Listeria m...
380
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05662
(
show subtarget assignments
)
1
soluble
No
lmo0303
16802349
-
putaive secreted, lysin rich protein [Li...
184
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91186
(
show subtarget assignments
)
1
in_crystallization_trials
No
CAA37605
47078
unnamed protein product [Streptomyces gr...
272
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ND4
39.8%
Streptomyces griseus
IDP05221
(
show subtarget assignments
)
1
expressed
No
BA_4349
30258849
hypothetical protein BA_4349 [Bacillus a...
62
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05237
(
show subtarget assignments
)
1
soluble
No
lmo1653
16803693
-
putative cellsurface protein [Listeria m...
201
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04368
(
show subtarget assignments
)
1
selected
No
BAS3746
49186745
isoleucyl-tRNA synthetase [Bacillus anth...
921
Proposed to be essential proteins
Phase 4: April 2009
1FFY
63.3%
Bacillus anthracis
IDP91188
(
show subtarget assignments
)
1
crystallized
No
CAA24743
40923
unnamed protein product [Escherichia col...
341
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OVC
100%
Escherichia coli
IDP91541
(
show subtarget assignments
)
8
selected
No
TGME49_118680
237841017
3',5'--cyclic-nucleotide phosphodiestera...
812
potential drug target /
Phosphodiesterases are key regulators of cell signalling pathways and are attrac...
Community Requests
3QI3
13.8%
Toxoplasma gondii
IDP05653
(
show subtarget assignments
)
1
cloned
No
lmo0146
16802194
-
hypothetical protein lmo0146 [Listeria m...
68
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP91619
(
show subtarget assignments
)
8
soluble
No
BAB36095
13362140
ECs2672
hypothetical protein [Escherichia coli O...
379
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1G9U
13.5%
Escherichia coli
IDP91191
(
show subtarget assignments
)
1
in_pdb
4EJ7
3R78
No
CAJ77079
90265397
aphA1
Aminoglycoside phosphotransferase [Acine...
271
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R78
100%
Acinetobacter baumannii
IDP91190
(
show subtarget assignments
)
1
in_crystallization_trials
No
EF_A0061
29345308
6'-aminoglycoside N-acetyltransferase [E...
479
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R6Z
20%
Enterococcus faecalis
IDP04383
(
show subtarget assignments
)
1
purified
No
BAS4455
49187450
phenylalanyl-tRNA synthetase subunit bet...
806
Proposed to be essential proteins
Phase 4: April 2009
2RHS
49.8%
Bacillus anthracis
IDP91020
(
show subtarget assignments
)
8
in_crystallization_trials
No
y2842
22126718
hypothetical protein y2842 [Yersinia pes...
378
other biological interest /
putative periplasmic iron-binding protein
Community Requests
2ETV
22.8%
Yersinia pestis
IDP91032
(
show subtarget assignments
)
8
cloned
No
Y1069
31795399
toxin [Yersinia pestis KIM]
587
virulence/pathogenesis /
survival factor of Y pestis in the flea
Community Requests
1F0I
22.7%
Yersinia pestis
IDP91022
(
show subtarget assignments
)
8
cloned
No
y2966
22126843
ompC
outer membrane porin protein C [Yersinia...
374
drug resistance /
outer membrane porin
Community Requests
2IXX
67.9%
Yersinia pestis
IDP91195
(
show subtarget assignments
)
8
cloned
No
BAS4091
49187089
-
Stage III sporulation protein AG
220
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP91198
(
show subtarget assignments
)
8
cloned
No
BAS5131
49188117
-
stage II sporulation protein
301
essential/virulence/pathogenesis /
Essential proteins
Community Requests
3TUF
33.6%
Bacillus anthracis
IDP04005
(
show subtarget assignments
)
1
purified
No
BAS4355
49187350
valyl-tRNA synthetase [Bacillus anthraci...
881
Proposed to be essential proteins
Phase 4: April 2009
1GAX
42.6%
Bacillus anthracis
IDP91196
(
show subtarget assignments
)
8
soluble
No
BAS4097
49187095
-
Stage III sporulation protein AA
308
essential/virulence/pathogenesis /
Essential proteins
Community Requests
Bacillus anthracis
IDP05175
(
show subtarget assignments
)
1
expressed
No
lmo1656
16803696
-
hypothetical protein lmo1656 [Listeria m...
143
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP04003
(
show subtarget assignments
)
1
cloned
No
BAS0126
49183160
50S ribosomal protein L18 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1OVY
75.8%
Bacillus anthracis
IDP04107
(
show subtarget assignments
)
1
purified
No
BAS0120
49183154
50S ribosomal protein L14 [Bacillus anth...
122
Proposed to be essential proteins
Phase 4: April 2009
1C04
86.9%
Bacillus anthracis
IDP91952
(
show subtarget assignments
)
8
selected
No
SpneCM_010100008682
298255656
AmiA protein [Streptococcus pneumoniae s...
659
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1B05
23.4%
Streptococcus pneumoniae
IDP91951
(
show subtarget assignments
)
8
in_crystallization_trials
No
SpneCM_010100010278
298255964
general stress protein GSP-781 [Streptoc...
392
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2K3A
9.4%
Streptococcus pneumoniae
previous
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
next
Filter Columns
Filter Columns:
Target Id
Locus Tag
Priority
Stage
Has Screening
Ncbi Gi
Gene Name
Common Name
Length
Justification
Project
Homolog Pdb Id
Homolog Sequence Identity
Organism
Tigr Main Role
Tigr Sub Role
