Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02006 (show subtarget assignments)	1	expressed	No	STM2285	16765612	glpB	anaerobic glycerol-3-phosphate dehydroge...	419	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Energy metabolism	Anaerobic

IDP01989 (show subtarget assignments)	1	purified	No	STM2646	16765966	yfiD	autonomous glycyl radical cofactor GrcA ...	127	Conserved; Drug target functions	Phase 3: June 2008	1CM5	38.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP00543 (show subtarget assignments)	1	purified	No	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP04463 (show subtarget assignments)	1	cloned	No	YPO1959	115347684	narR	nitrate/nitrite sensor protein [Yersinia...	593	conserved gene; putative drug target function;	Phase 4: April 2009	3EZH	8.4%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02362 (show subtarget assignments)	1	cloned	No	GBAA1923	47777980	ldh	L-lactate dehydrogenase [Bacillus anthra...	314	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PQD	64.6%	Bacillus anthracis	Energy metabolism	Anaerobic

IDP02190 (show subtarget assignments)	1	expressed	No	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP00930 (show subtarget assignments)	1	expressed	No	STM0612	16763989		putative hydrogenase protein	185	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	30.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01908 (show subtarget assignments)	1	cloned	No	STM1392	16764742	ssrA	sensor kinase [Salmonella typhimurium LT...	920	Conserved; Drug target functions	Phase 3: June 2008	2C2A	7.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01930 (show subtarget assignments)	1	expressed	No	STM1578	16764922	narY	nitrate reductase 2 beta subunit [Salmon...	514	Conserved; Essential; Drug target functions	Phase 3: June 2008	1Q16	79%	Salmonella enterica	Energy metabolism	Anaerobic

IDP00878 (show subtarget assignments)	1	expressed	No	STM4306	16767556		putative anaerobic dimethylsulfoxide red...	208	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	29.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01867 (show subtarget assignments)	1	cloned	No	YPO0160	16120503	nirD	nitrite reductase small subunit [Yersini...	108	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2JZA	71.3%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01841 (show subtarget assignments)	1	purified	No	STM2549	16765869	asrB	anaerobic sulfite reductase subunit B [S...	272	Conserved; Drug target functions	Phase 3: June 2008	1KRH	18.8%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01474 (show subtarget assignments)	1	expressed	No	VC2657	15642652		fumarate reductase iron-sulfur subunit	252	Conserved Gene / Pathway	Phase 2: March 2008	1KF6	69%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP01518 (show subtarget assignments)	1	purified	No	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP02018 (show subtarget assignments)	1	expressed	No	STM2530	16765850		putative anaerobic dimethylsulfoxide red...	801	Conserved; Drug target functions	Phase 3: June 2008	1DMR	30.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP04512 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2342	110798786	modA	molybdate ABC transporter, molybdate-bin...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AMF	33.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP00935 (show subtarget assignments)	1	purified	No	STM0783	16764147	modC	molybdate transporter ATP-binding protei...	352	Conserved Gene / Pathway	Phase 2: March 2008	3D31	29.5%	Salmonella enterica	Transport and binding proteins	Anions

IDP00934 (show subtarget assignments)	0	work_stopped	No	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP02180 (show subtarget assignments)	1	cloned	No	Cj0299	15791667		putative periplasmic beta-lactamase [Cam...	257	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	1E3U	34.6%	Campylobacter jejuni	Transport and binding proteins	Anions

IDP00717 (show subtarget assignments)	1	cloned	No	SACOL1421	57286072		phosphate ABC transporter, ATP-binding p...	283	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.9%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP00716 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1420	57286071		phosphate transport system protein PhoU,...	213	Conserved Gene / Pathway	Phase 2: March 2008	1T72	31%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP01340 (show subtarget assignments)	1	expressed	No	VCA0073	15600844		phosphate ABC transporter, ATP-binding p...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	37.1%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01333 (show subtarget assignments)	1	purified	No	VC0726	15640745		phosphate ABC transporter, ATP-binding p...	273	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	33%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01150 (show subtarget assignments)	1	expressed	No	BA_4493	34582388		Phosphate import ATP-binding protein pst...	271	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.8%	Bacillus anthracis	Transport and binding proteins	Anions

IDP02059 (show subtarget assignments)	1	expressed	No	YPO1353	16121633		chorismate mutase [Yersinia pestis CO92]...	186	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2GBB	83.9%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02833 (show subtarget assignments)	1	cloned	No	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02414 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1154c	56708225	aroB	3-dehydroquinate synthase [Francisella t...	359	Conserved; Drug target functions	Phase 3: June 2008	3OKF	44.3%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP01058 (show subtarget assignments)	1	in_crystallization_trials	No	STM3486	16766774	aroB	3-dehydroquinate synthase	362	Conserved Gene / Pathway	Phase 2: March 2008	3OKF	62.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02625 (show subtarget assignments)	1	cloned	No	GBAA4457	47529752	aroK	shikimate kinase [Bacillus anthracis str...	165	Conserved; Drug target functions	Phase 3: June 2008	1ZUH	35.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00539 (show subtarget assignments)	1	purified	No	YPO2751	16122955	aroC	chorismate synthase	361	Conserved Gene / Pathway	Phase 2: March 2008	1R52	45%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP01013 (show subtarget assignments)	1	purified	No	STM2670	16765985	aroF	phospho-2-dehydro-3-deoxyheptonate aldol...	356	Conserved Gene / Pathway	Phase 2: March 2008	1GG1	51.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP02836 (show subtarget assignments)	1	crystallized	No	GBAA4423	47529716	aroQ	3-dehydroquinate dehydratase [Bacillus a...	146	Conserved; Drug target functions	Phase 3: June 2008	1GQO	57.5%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04468 (show subtarget assignments)	1	cloned	No	YPO2205	115347912	trpC	tryptophan biosynthesis protein TrpCF [Y...	475	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PII	69.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00950 (show subtarget assignments)	1	soluble	No	STM1119	16764477	wraB	TrpR binding protein WrbA	198	Conserved Gene / Pathway	Phase 2: March 2008	2R96	94.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00946 (show subtarget assignments)	1	expressed	No	STM0978	16764338	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	427	Conserved Gene / Pathway	Phase 2: March 2008	1G6S	89.5%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00012 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2953	61211623		3-phosphoshikimate 1-carboxyvinyltransfe...	429	Drug Target Homolog	Phase 1: October 2007	3RMT	66.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01921 (show subtarget assignments)	1	expressed	No	CBU_1154	29541726	trpC	indole-3-glycerol phosphate synthase [Co...	257	Conserved; Drug target functions	Phase 3: June 2008	3QJA	37%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02604 (show subtarget assignments)	1	expressed	No	CBU_1893	29542450	aroB	3-dehydroquinate synthase [Coxiella burn...	360	Conserved; Drug target functions	Phase 3: June 2008	3OKF	48.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00482 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1758	16122014	manX	PTS system, mannose-specific IIAB compon...	324	Virulence Associated Factor	Phase 2: March 2008	2JZH	45.4%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02159 (show subtarget assignments)	1	cloned	No	CBU_1892	29542449	aroK	shikimate kinase [Coxiella burnetii RSA ...	179	Conserved; Drug target functions	Phase 3: June 2008	3TRF	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00461 (show subtarget assignments)	1	expressed	No	YPO3285	16123440	tyrA	bifunctional chorismate mutase/prephenat...	373	Conserved Gene / Pathway	Phase 2: March 2008	2PV7	47.2%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02501 (show subtarget assignments)	1	cloned	No	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00856 (show subtarget assignments)	1	purified	No	STM0388	16763768	aroL	shikimate kinase II	181	Conserved Gene / Pathway	Phase 2: March 2008	1SHK	48.6%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00847 (show subtarget assignments)	1	expressed	No	SACOL1404	57284558	trpG	anthranilate synthase, glutamine amidotr...	188	Drug Target Function	Phase 2: March 2008	1QDL	34.2%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP02320 (show subtarget assignments)	1	purified	No	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02318 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01866 (show subtarget assignments)	1	crystallized	No	FTT1772c	56708766	trpA	tryptophan synthase subunit alpha [Franc...	269	Drug Target	Phase 3: June 2008	3NAV	61%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00441 (show subtarget assignments)	1	expressed	No	YPO2207	16122435	trpG	anthranilate synthase component II	192	Drug Target Function	Phase 2: March 2008	1I7Q	87.5%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00440 (show subtarget assignments)	1	purified	No	YPO2208	16122436	trpE	anthranilate synthase component I	521	Conserved Gene / Pathway	Phase 2: March 2008	1I7Q	79.7%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP04293 (show subtarget assignments)	1	in_pdb 3OXP	Yes	YPO2569	218929655		phosphotransferase enzyme II, A componen...	147	conserved gene; putative drug target function;	Phase 4: April 2009	3OXP	100%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00804 (show subtarget assignments)	1	expressed	No	SACOL1787	57286221		bifunctional 3-deoxy-7-phosphoheptulonat...	363	Drug Target Function	Phase 2: March 2008	3NVT	66.9%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP04232 (show subtarget assignments)	1	cloned	No	CPF_0693	110799915	aroE	shikimate 5-dehydrogenase [Clostridium p...	271	conserved gene; putative drug target function;	Phase 4: April 2009	3FBT	46.9%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP01842 (show subtarget assignments)	1	in_pdb 3SLH 4EGR 3ROI	Yes	CBU_0526	29541129	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	438	Conserved; Drug target functions	Phase 3: June 2008	3ROI	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02433 (show subtarget assignments)	1	expressed	No	CBU_0010	29540636	aroE	shikimate 5-dehydrogenase [Coxiella burn...	272	Conserved; Drug target functions	Phase 3: June 2008	1NYT	46.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00350 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00349 (show subtarget assignments)	1	expressed	No	lmo1632	16803672	trpG	hypothetical protein lmo1632	201	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1I1Q	39.3%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00348 (show subtarget assignments)	1	in_pdb 3TFC 3NVT	No	lmo1600	16803640	aroA	bifunctional 3-deoxy-7-phosphoheptulonat...	361	Drug Target Function	Phase 2: March 2008	3NVT	100%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP04176 (show subtarget assignments)	1	in_pdb 3OKF	No	VC2628	15642623	aroB	3-dehydroquinate synthase [Vibrio choler...	366	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3OKF	100%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02271 (show subtarget assignments)	1	crystallized	No	FTT1155c	56708226	aroK	shikimate kinase I [Francisella tularens...	176	Conserved; Drug target functions	Phase 3: June 2008	1KAG	58%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP04161 (show subtarget assignments)	1	cloned	No	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00342 (show subtarget assignments)	1	cloned	No	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00338 (show subtarget assignments)	1	cloned	No	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00337 (show subtarget assignments)	1	expressed	No	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP04177 (show subtarget assignments)	1	crystallized	No	VC2629	9657219		shikimate kinase [Vibrio cholerae O1 bio...	174	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KAG	81%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00330 (show subtarget assignments)	1	purified	No	Cj0345	15791713	trpE	putative anthranilate synthase component...	416	Drug Target Function	Phase 2: March 2008	1QDL	32%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP04160 (show subtarget assignments)	1	in_pdb 3NAV	No	VC1169	9655645		tryptophan synthase, alpha subunit [Vibr...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3NAV	100%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00009 (show subtarget assignments)	1	soluble	No	BA_1538	38372188		3-dehydroquinate synthase	363	Drug Target Homolog	Phase 1: October 2007	1XAG	38.3%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00322 (show subtarget assignments)	1	expressed	No	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP00319 (show subtarget assignments)	1	expressed	No	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00315 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01199 (show subtarget assignments)	1	purified	No	BA_1537	67460530		Chorismate synthase 1 (5-enolpyruvylshik...	390	Drug Target Function	Phase 2: March 2008	1QXO	59%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01196 (show subtarget assignments)	1	expressed	No	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02435 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0152	16120495	aroB	3-dehydroquinate synthase [Yersinia pest...	362	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3OKF	63.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP04090 (show subtarget assignments)	1	crystallized	No	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP00302 (show subtarget assignments)	1	expressed	No	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01211 (show subtarget assignments)	1	crystallized	No	BA_2958	30257549		chorismate mutase/phospho-2-dehydro-3-de...	358	Drug Target Function	Phase 2: March 2008	3NVT	69.8%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01813 (show subtarget assignments)	1	purified	No	GBAA1253	47526519	trpB	tryptophan synthase subunit beta [Bacill...	397	Conserved; Drug target functions	Phase 3: June 2008	1X1Q	63%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02405 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP01871 (show subtarget assignments)	1	cloned	No	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP00586 (show subtarget assignments)	1	purified	No	YPO3789	16123923	metR	lysR-family transcriptional regulatory p...	317	Virulence Associated Factor	Phase 2: March 2008	1AL3	23.7%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00585 (show subtarget assignments)	1	expressed	No	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00584 (show subtarget assignments)	1	soluble	No	YPO0117	16120462	metF	5,10-methylenetetrahydrofolate reductase...	294	Virulence Associated Factor	Phase 2: March 2008	1ZP3	86.4%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02060 (show subtarget assignments)	1	expressed	No	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04704 (show subtarget assignments)	1	cloned	No	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00571 (show subtarget assignments)	1	in_pdb 3GOS	No	YPO1041	16121341	dapD	2,3,4,5-tetrahydropyridine-2-carboxylate...	274	Virulence Associated Factor	Phase 2: March 2008	3GOS	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01080 (show subtarget assignments)	0	work_stopped	No	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP02006
(show subtarget assignments)

1

expressed

No

STM2285

16765612

glpB

anaerobic glycerol-3-phosphate dehydroge...

419

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Energy metabolism

Anaerobic

IDP01989
(show subtarget assignments)

1

purified

No

STM2646

16765966

yfiD

autonomous glycyl radical cofactor GrcA ...

127

Conserved; Drug target functions

Phase 3: June 2008

1CM5

38.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP00543
(show subtarget assignments)

1

purified

No

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP04463
(show subtarget assignments)

1

cloned

No

YPO1959

115347684

narR

nitrate/nitrite sensor protein [Yersinia...

593

conserved gene; putative drug target function;

Phase 4: April 2009

3EZH

8.4%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02362
(show subtarget assignments)

1

cloned

No

GBAA1923

47777980

ldh

L-lactate dehydrogenase [Bacillus anthra...

314

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PQD

64.6%

Bacillus anthracis

Energy metabolism

Anaerobic

IDP02190
(show subtarget assignments)

1

expressed

No

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP00930
(show subtarget assignments)

1

expressed

No

STM0612

16763989

putative hydrogenase protein

185

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

30.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01908
(show subtarget assignments)

1

cloned

No

STM1392

16764742

ssrA

sensor kinase [Salmonella typhimurium LT...

920

Conserved; Drug target functions

Phase 3: June 2008

2C2A

7.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01930
(show subtarget assignments)

1

expressed

No

STM1578

16764922

narY

nitrate reductase 2 beta subunit [Salmon...

514

Conserved; Essential; Drug target functions

Phase 3: June 2008

1Q16

79%

Salmonella enterica

Energy metabolism

Anaerobic

IDP00878
(show subtarget assignments)

1

expressed

No

STM4306

16767556

putative anaerobic dimethylsulfoxide red...

208

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

29.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01867
(show subtarget assignments)

1

cloned

No

YPO0160

16120503

nirD

nitrite reductase small subunit [Yersini...

108

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2JZA

71.3%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01841
(show subtarget assignments)

1

purified

No

STM2549

16765869

asrB

anaerobic sulfite reductase subunit B [S...

272

Conserved; Drug target functions

Phase 3: June 2008

1KRH

18.8%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01474
(show subtarget assignments)

1

expressed

No

VC2657

15642652

fumarate reductase iron-sulfur subunit

252

Conserved Gene / Pathway

Phase 2: March 2008

1KF6

69%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP01518
(show subtarget assignments)

1

purified

No

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP02018
(show subtarget assignments)

1

expressed

No

STM2530

16765850

putative anaerobic dimethylsulfoxide red...

801

Conserved; Drug target functions

Phase 3: June 2008

1DMR

30.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP04512
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2342

110798786

modA

molybdate ABC transporter, molybdate-bin...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AMF

33.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP00935
(show subtarget assignments)

1

purified

No

STM0783

16764147

modC

molybdate transporter ATP-binding protei...

352

Conserved Gene / Pathway

Phase 2: March 2008

3D31

29.5%

Salmonella enterica

Transport and binding proteins

Anions

IDP00934
(show subtarget assignments)

0

work_stopped

No

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP02180
(show subtarget assignments)

1

cloned

No

Cj0299

15791667

putative periplasmic beta-lactamase [Cam...

257

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

1E3U

34.6%

Campylobacter jejuni

Transport and binding proteins

Anions

IDP00717
(show subtarget assignments)

1

cloned

No

SACOL1421

57286072

phosphate ABC transporter, ATP-binding p...

283

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.9%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP00716
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1420

57286071

phosphate transport system protein PhoU,...

213

Conserved Gene / Pathway

Phase 2: March 2008

1T72

31%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP01340
(show subtarget assignments)

1

expressed

No

VCA0073

15600844

phosphate ABC transporter, ATP-binding p...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

37.1%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01333
(show subtarget assignments)

1

purified

No

VC0726

15640745

phosphate ABC transporter, ATP-binding p...

273

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

33%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01150
(show subtarget assignments)

1

expressed

No

BA_4493

34582388

Phosphate import ATP-binding protein pst...

271

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.8%

Bacillus anthracis

Transport and binding proteins

Anions

IDP02059
(show subtarget assignments)

1

expressed

No

YPO1353

16121633

chorismate mutase [Yersinia pestis CO92]...

186

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2GBB

83.9%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02833
(show subtarget assignments)

1

cloned

No

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02414
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1154c

56708225

aroB

3-dehydroquinate synthase [Francisella t...

359

Conserved; Drug target functions

Phase 3: June 2008

3OKF

44.3%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP01058
(show subtarget assignments)

1

in_crystallization_trials

No

STM3486

16766774

aroB

3-dehydroquinate synthase

362

Conserved Gene / Pathway

Phase 2: March 2008

3OKF

62.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02625
(show subtarget assignments)

1

cloned

No

GBAA4457

47529752

aroK

shikimate kinase [Bacillus anthracis str...

165

Conserved; Drug target functions

Phase 3: June 2008

1ZUH

35.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00539
(show subtarget assignments)

1

purified

No

YPO2751

16122955

aroC

chorismate synthase

361

Conserved Gene / Pathway

Phase 2: March 2008

1R52

45%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP01013
(show subtarget assignments)

1

purified

No

STM2670

16765985

aroF

phospho-2-dehydro-3-deoxyheptonate aldol...

356

Conserved Gene / Pathway

Phase 2: March 2008

1GG1

51.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP02836
(show subtarget assignments)

1

crystallized

No

GBAA4423

47529716

aroQ

3-dehydroquinate dehydratase [Bacillus a...

146

Conserved; Drug target functions

Phase 3: June 2008

1GQO

57.5%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04468
(show subtarget assignments)

1

cloned

No

YPO2205

115347912

trpC

tryptophan biosynthesis protein TrpCF [Y...

475

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PII

69.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00950
(show subtarget assignments)

1

soluble

No

STM1119

16764477

wraB

TrpR binding protein WrbA

198

Conserved Gene / Pathway

Phase 2: March 2008

2R96

94.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00946
(show subtarget assignments)

1

expressed

No

STM0978

16764338

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

427

Conserved Gene / Pathway

Phase 2: March 2008

1G6S

89.5%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00012
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2953

61211623

3-phosphoshikimate 1-carboxyvinyltransfe...

429

Drug Target Homolog

Phase 1: October 2007

3RMT

66.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01921
(show subtarget assignments)

1

expressed

No

CBU_1154

29541726

trpC

indole-3-glycerol phosphate synthase [Co...

257

Conserved; Drug target functions

Phase 3: June 2008

3QJA

37%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02604
(show subtarget assignments)

1

expressed

No

CBU_1893

29542450

aroB

3-dehydroquinate synthase [Coxiella burn...

360

Conserved; Drug target functions

Phase 3: June 2008

3OKF

48.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00482
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1758

16122014

manX

PTS system, mannose-specific IIAB compon...

324

Virulence Associated Factor

Phase 2: March 2008

2JZH

45.4%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02159
(show subtarget assignments)

1

cloned

No

CBU_1892

29542449

aroK

shikimate kinase [Coxiella burnetii RSA ...

179

Conserved; Drug target functions

Phase 3: June 2008

3TRF

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00461
(show subtarget assignments)

1

expressed

No

YPO3285

16123440

tyrA

bifunctional chorismate mutase/prephenat...

373

Conserved Gene / Pathway

Phase 2: March 2008

2PV7

47.2%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02501
(show subtarget assignments)

1

cloned

No

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00856
(show subtarget assignments)

1

purified

No

STM0388

16763768

aroL

shikimate kinase II

181

Conserved Gene / Pathway

Phase 2: March 2008

1SHK

48.6%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00847
(show subtarget assignments)

1

expressed

No

SACOL1404

57284558

trpG

anthranilate synthase, glutamine amidotr...

188

Drug Target Function

Phase 2: March 2008

1QDL

34.2%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP02320
(show subtarget assignments)

1

purified

No

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02318
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01866
(show subtarget assignments)

1

crystallized

No

FTT1772c

56708766

trpA

tryptophan synthase subunit alpha [Franc...

269

Drug Target

Phase 3: June 2008

3NAV

61%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00441
(show subtarget assignments)

1

expressed

No

YPO2207

16122435

trpG

anthranilate synthase component II

192

Drug Target Function

Phase 2: March 2008

1I7Q

87.5%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00440
(show subtarget assignments)

1

purified

No

YPO2208

16122436

trpE

anthranilate synthase component I

521

Conserved Gene / Pathway

Phase 2: March 2008

1I7Q

79.7%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP04293
(show subtarget assignments)

1

in_pdb
3OXP

Yes

YPO2569

218929655

phosphotransferase enzyme II, A componen...

147

conserved gene; putative drug target function;

Phase 4: April 2009

3OXP

100%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00804
(show subtarget assignments)

1

expressed

No

SACOL1787

57286221

bifunctional 3-deoxy-7-phosphoheptulonat...

363

Drug Target Function

Phase 2: March 2008

3NVT

66.9%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP04232
(show subtarget assignments)

1

cloned

No

CPF_0693

110799915

aroE

shikimate 5-dehydrogenase [Clostridium p...

271

conserved gene; putative drug target function;

Phase 4: April 2009

3FBT

46.9%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP01842
(show subtarget assignments)

1

in_pdb
3SLH
4EGR
3ROI

Yes

CBU_0526

29541129

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

438

Conserved; Drug target functions

Phase 3: June 2008

3ROI

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02433
(show subtarget assignments)

1

expressed

No

CBU_0010

29540636

aroE

shikimate 5-dehydrogenase [Coxiella burn...

272

Conserved; Drug target functions

Phase 3: June 2008

1NYT

46.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00350
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00349
(show subtarget assignments)

1

expressed

No

lmo1632

16803672

trpG

hypothetical protein lmo1632

201

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1I1Q

39.3%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00348
(show subtarget assignments)

1

in_pdb
3TFC
3NVT

No

lmo1600

16803640

aroA

bifunctional 3-deoxy-7-phosphoheptulonat...

361

Drug Target Function

Phase 2: March 2008

3NVT

100%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP04176
(show subtarget assignments)

1

in_pdb
3OKF

No

VC2628

15642623

aroB

3-dehydroquinate synthase [Vibrio choler...

366

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3OKF

100%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02271
(show subtarget assignments)

1

crystallized

No

FTT1155c

56708226

aroK

shikimate kinase I [Francisella tularens...

176

Conserved; Drug target functions

Phase 3: June 2008

1KAG

58%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP04161
(show subtarget assignments)

1

cloned

No

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00342
(show subtarget assignments)

1

cloned

No

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00338
(show subtarget assignments)

1

cloned

No

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00337
(show subtarget assignments)

1

expressed

No

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP04177
(show subtarget assignments)

1

crystallized

No

VC2629

9657219

shikimate kinase [Vibrio cholerae O1 bio...

174

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KAG

81%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00330
(show subtarget assignments)

1

purified

No

Cj0345

15791713

trpE

putative anthranilate synthase component...

416

Drug Target Function

Phase 2: March 2008

1QDL

32%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP04160
(show subtarget assignments)

1

in_pdb
3NAV

No

VC1169

9655645

tryptophan synthase, alpha subunit [Vibr...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3NAV

100%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00009
(show subtarget assignments)

1

soluble

No

BA_1538

38372188

3-dehydroquinate synthase

363

Drug Target Homolog

Phase 1: October 2007

1XAG

38.3%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00322
(show subtarget assignments)

1

expressed

No

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP00319
(show subtarget assignments)

1

expressed

No

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00315
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01199
(show subtarget assignments)

1

purified

No

BA_1537

67460530

Chorismate synthase 1 (5-enolpyruvylshik...

390

Drug Target Function

Phase 2: March 2008

1QXO

59%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01196
(show subtarget assignments)

1

expressed

No

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02435
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0152

16120495

aroB

3-dehydroquinate synthase [Yersinia pest...

362

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3OKF

63.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP04090
(show subtarget assignments)

1

crystallized

No

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP00302
(show subtarget assignments)

1

expressed

No

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01211
(show subtarget assignments)

1

crystallized

No

BA_2958

30257549

chorismate mutase/phospho-2-dehydro-3-de...

358

Drug Target Function

Phase 2: March 2008

3NVT

69.8%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01813
(show subtarget assignments)

1

purified

No

GBAA1253

47526519

trpB

tryptophan synthase subunit beta [Bacill...

397

Conserved; Drug target functions

Phase 3: June 2008

1X1Q

63%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02405
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP01871
(show subtarget assignments)

1

cloned

No

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP00586
(show subtarget assignments)

1

purified

No

YPO3789

16123923

metR

lysR-family transcriptional regulatory p...

317

Virulence Associated Factor

Phase 2: March 2008

1AL3

23.7%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00585
(show subtarget assignments)

1

expressed

No

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00584
(show subtarget assignments)

1

soluble

No

YPO0117

16120462

metF

5,10-methylenetetrahydrofolate reductase...

294

Virulence Associated Factor

Phase 2: March 2008

1ZP3

86.4%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02060
(show subtarget assignments)

1

expressed

No

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04704
(show subtarget assignments)

1

cloned

No

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00571
(show subtarget assignments)

1

in_pdb
3GOS

No

YPO1041

16121341

dapD

2,3,4,5-tetrahydropyridine-2-carboxylate...

274

Virulence Associated Factor

Phase 2: March 2008

3GOS

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01080
(show subtarget assignments)

0

work_stopped

No

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

Targets