Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00301 (show subtarget assignments)	1	expressed	No	CBU_0983				291	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	3NVT	10.7%	Coxiella burnetii

IDP01858 (show subtarget assignments)	1	cloned	No	CBU_0993	29541575	def	peptide deformylase [Coxiella burnetii R...	170	Conserved; Drug target functions	Phase 3: June 2008	1N5N	47.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP02176 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02046 (show subtarget assignments)	1	soluble	No	CBU_1007	29541589	bioB	biotin synthase [Coxiella burnetii RSA 4...	321	Conserved; Drug target functions	Phase 3: June 2008	1R30	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01797 (show subtarget assignments)	1	cloned	No	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02060 (show subtarget assignments)	1	expressed	No	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01805 (show subtarget assignments)	1	soluble	No	CBU_1084	29541658		sensory box sensor histidine kinase/resp...	683	Conserved; Drug target functions	Phase 3: June 2008	2C2A	12.4%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01734 (show subtarget assignments)	1	cloned	No	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP01932 (show subtarget assignments)	1	cloned	No	CBU_1099	29541673	lepB-1	signal peptidase I [Coxiella burnetii RS...	259	Conserved; Drug target functions	Phase 3: June 2008	1T7D	33.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02200 (show subtarget assignments)	1	cloned	No	CBU_1103	29541677		transglycosylase, Slt family [Coxiella b...	425	Conserved; Drug target functions	Phase 3: June 2008	1QSA	16.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91586 (show subtarget assignments)	8	expressed	No	CBU_1107	29541681		hypothetical protein	306	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91587 (show subtarget assignments)	8	expressed	No	CBU_1108	29541682		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01735 (show subtarget assignments)	1	soluble	No	CBU_1129	29541703	nifS	cysteine desulfurase [Coxiella burnetii ...	396	Conserved; Drug target functions	Phase 3: June 2008	1P3W	57.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00300 (show subtarget assignments)	1	cloned	No	CBU_1153				548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	1GXB	10.4%	Coxiella burnetii

IDP01921 (show subtarget assignments)	1	expressed	No	CBU_1154	29541726	trpC	indole-3-glycerol phosphate synthase [Co...	257	Conserved; Drug target functions	Phase 3: June 2008	3QJA	37%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00302 (show subtarget assignments)	1	expressed	No	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02019 (show subtarget assignments)	1	cloned	No	CBU_1182	29541752	iscS	cysteine desulfurase [Coxiella burnetii ...	380	Conserved; Drug target functions	Phase 3: June 2008	1P3W	43.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01731 (show subtarget assignments)	1	expressed	No	CBU_1222	29541792	dapA	dihydrodipicolinate synthase [Coxiella b...	289	Conserved; Drug target functions	Phase 3: June 2008	3QZE	55.2%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP02021 (show subtarget assignments)	1	cloned	No	CBU_1240	29541810	gcp	O-sialoglycoprotein endopeptidase [Coxie...	339	Conserved; Drug target functions	Phase 3: June 2008	2IVN	36%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02160 (show subtarget assignments)	1	soluble	No	CBU_1245	29541815		GTP-binding protein [Coxiella burnetii R...	443	Conserved; Drug target functions	Phase 3: June 2008	2HJG	38.4%	Coxiella burnetii	Unknown function	General

IDP02030 (show subtarget assignments)	1	expressed	No	CBU_1255	29541825		geranyltranstransferase, putative [Coxie...	267	Conserved; Drug target functions	Phase 3: June 2008	3TS7	40.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02776 (show subtarget assignments)	1	expressed	No	CBU_1266	29541836	lipA	lipoic acid synthetase [Coxiella burneti...	315	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP02168 (show subtarget assignments)	1	expressed	No	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02646 (show subtarget assignments)	1	expressed	No	CBU_1290	29541858	dnaK	chaperone protein dnak [Coxiella burneti...	656	Conserved; Drug target functions	Phase 3: June 2008	2KHO	68.9%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02284 (show subtarget assignments)	1	soluble	No	CBU_1293	29541861	grpE	heat shock protein GrpE [Coxiella burnet...	204	Conserved; Drug target functions	Phase 3: June 2008	1DKG	35.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02225 (show subtarget assignments)	1	cloned	No	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01743 (show subtarget assignments)	1	purified	No	CBU_1350	29541915	glmM	phosphoglucosamine mutase [Coxiella burn...	446	Conserved; Drug target functions	Phase 3: June 2008	3PDK	44.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02022 (show subtarget assignments)	1	expressed	No	CBU_1351	29541916	folP	dihydropteroate synthase [Coxiella burne...	297	Conserved; Drug target functions	Phase 3: June 2008	3TR9	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP02062 (show subtarget assignments)	1	soluble	No	CBU_1357	29541922	csdB	selenocysteine lyase [Coxiella burnetii ...	405	Conserved; Drug target functions	Phase 3: June 2008	1I29	50.9%	Coxiella burnetii	Central intermediary metabolism	Other

IDP02511 (show subtarget assignments)	1	soluble	No	CBU_1359	29541924	sufC	ABC transporter, ATP-binding protein [Co...	244	Conserved; Drug target functions	Phase 3: June 2008	2D3W	63.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01815 (show subtarget assignments)	1	soluble	No	CBU_1382	29541947	uppS	undecaprenyl diphosphate synthase [Coxie...	237	Conserved; Drug target functions	Phase 3: June 2008	1JP3	49.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02071 (show subtarget assignments)	1	expressed	No	CBU_1388	29541953	map	methionine aminopeptidase, type I [Coxie...	258	Conserved; Drug target functions	Community Interest	1MAT	65.1%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01846 (show subtarget assignments)	1	soluble	No	CBU_1419	29541979		serine hydroxymethyltransferase [Coxiell...	419	Conserved; Drug target functions	Phase 3: June 2008	1DFO	68.5%	Coxiella burnetii	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02270 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1424	29541984	hemB	porphobilinogen synthase [Coxiella burne...	334	Conserved; Drug target functions	Phase 3: June 2008	1W1Z	48.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02682 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1502	29542061	era	GTP-binding protein Era [Coxiella burnet...	295	Conserved; Drug target functions	Phase 3: June 2008	1EGA	51.2%	Coxiella burnetii	Regulatory functions	RNA interactions

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02199 (show subtarget assignments)	1	expressed	No	CBU_1505	29542064	lepA	GTP-binding protein LepA [Coxiella burne...	614	Conserved; Drug target functions	Phase 3: June 2008	3CB4	69.9%	Coxiella burnetii	Unknown function	General

IDP01976 (show subtarget assignments)	1	in_pdb 3K96	Yes	CBU_1518	29542077	gpsA	glycerol-3-phosphate dehydrogenase (NAD+...	332	Conserved; Drug target functions	Phase 3: June 2008	3K96	100%	Coxiella burnetii	Energy metabolism	Other

IDP91609 (show subtarget assignments)	8	cloned	No	CBU_1524	29542083		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91608 (show subtarget assignments)	8	cloned	No	CBU_1525	29542084		hypothetical protein	382	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91606 (show subtarget assignments)	8	expressed	No	CBU_1532	29542091		hypothetical protein	145	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP01691 (show subtarget assignments)	1	cloned	No	CBU_1575	29542135	tolR	tolR protein [Coxiella burnetii RSA 493]...	147	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Other

IDP02540 (show subtarget assignments)	1	cloned	No	CBU_1584	29542144	shaE	monovalent cation/proton antiporter subu...	115	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01853 (show subtarget assignments)	1	cloned	No	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP02378 (show subtarget assignments)	1	cloned	No	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01689 (show subtarget assignments)	1	soluble	No	CBU_1708	29542266	sodB	superoxide dismutase (fe) [Coxiella burn...	193	Conserved; Drug target functions	Phase 3: June 2008	3TQJ	100%	Coxiella burnetii	Cellular processes	Detoxification

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02390 (show subtarget assignments)	1	cloned	No	CBU_1718	29542276	groEL	chaperonin, 60 kDa [Coxiella burnetii RS...	552	Conserved; Drug target functions	Phase 3: June 2008	2EU1	75.5%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01690 (show subtarget assignments)	1	soluble	No	CBU_1719	29542277	groES	chaperonin, 10 kDa [Coxiella burnetii RS...	96	Conserved; Drug target functions	Phase 3: June 2008	3NX6	58.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01659 (show subtarget assignments)	1	crystallized	No	CBU_1739	29542296		tetrapyrrole (Corrin/Porphyrin) methylas...	285	Conserved; Drug target functions	Phase 3: June 2008	3KWP	42.1%	Coxiella burnetii	Unknown function	General

IDP02415 (show subtarget assignments)	1	soluble	No	CBU_1761	29542318		sensory box sensor histidine kinase/resp...	657	Conserved; Drug target functions	Phase 3: June 2008	2C2A	11.6%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP02431 (show subtarget assignments)	1	crystallized	No	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91607 (show subtarget assignments)	8	cloned	No	CBU_1776	29542333		hypothetical protein	181	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01927 (show subtarget assignments)	1	expressed	No	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP02070 (show subtarget assignments)	1	expressed	No	CBU_1809	29542365		ABC transporter, ATP-binding protein [Co...	221	Conserved; Drug target functions	Phase 3: June 2008	1F3O	49.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91604 (show subtarget assignments)	8	cloned	No	CBU_1823	29542379		hypothetical protein	349	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91605 (show subtarget assignments)	8	cloned	No	CBU_1825	29542381		hypothetical protein	115	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP02675 (show subtarget assignments)	1	expressed	No	CBU_1842	29542398		GTP-binding protein YchF [Coxiella burne...	363	Conserved; Drug target functions	Phase 3: June 2008	1JAL	65.3%	Coxiella burnetii	Unknown function	General

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01624 (show subtarget assignments)	1	expressed	No	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01985 (show subtarget assignments)	1	expressed	No	CBU_1882	29542439	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	435	Conserved; Drug target functions	Phase 3: June 2008	4E77	60.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04631 (show subtarget assignments)	1	cloned	No	CBU_1891	215919282	pilQ	type II and III secretion system family ...	353	conserved gene;	Phase 4: April 2009			Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02159 (show subtarget assignments)	1	cloned	No	CBU_1892	29542449	aroK	shikimate kinase [Coxiella burnetii RSA ...	179	Conserved; Drug target functions	Phase 3: June 2008	3TRF	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02604 (show subtarget assignments)	1	expressed	No	CBU_1893	29542450	aroB	3-dehydroquinate synthase [Coxiella burn...	360	Conserved; Drug target functions	Phase 3: June 2008	3OKF	48.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01700 (show subtarget assignments)	1	expressed	No	CBU_1899	29542456		methyltransferase, putative [Coxiella bu...	193	Conserved; Drug target functions	Phase 3: June 2008	2FPO	51%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP01629 (show subtarget assignments)	1	cloned	No	CBU_1903	29542460	ftsY	signal recognition particle-docking prot...	324	Conserved; Drug target functions	Phase 3: June 2008	2YHS	58%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02371 (show subtarget assignments)	1	expressed	No	CBU_1904	29542461	ftsE	cell division ABC transporter, ATP-bindi...	217	Conserved; Drug target functions	Phase 3: June 2008	1F3O	38.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01628 (show subtarget assignments)	1	cloned	No	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91603 (show subtarget assignments)	8	cloned	No	CBU_1963	29542518		hypothetical protein	633	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01630 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1964	29542519	hemK	protein methyltransferase HemK [Coxiella...	277	Conserved; Drug target functions	Phase 3: June 2008	1T43	42.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP02522 (show subtarget assignments)	1	expressed	No	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP02165 (show subtarget assignments)	1	soluble	No	CBU_1993	29542548	folA	dihydrofolate reductase [Coxiella burnet...	161	Conserved; Drug target functions	Phase 3: June 2008	3TQ8	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04632 (show subtarget assignments)	1	cloned	No	CBU_2005	29655288	rstB	signal transduction histidine kinase-lik...	425	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.2%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP01995 (show subtarget assignments)	1	soluble	No	CBU_2012	29542567	hslU	heat shock protein HslVU, ATPase subunit...	447	Conserved; Drug target functions	Phase 3: June 2008	1DO0	67.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02069 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_2017	29542571	ubiE	ubiquinone/menaquinone biosynthesis meth...	250	Conserved; Drug target functions	Phase 3: June 2008	3SM3	19.6%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01631 (show subtarget assignments)	1	soluble	No	CBU_2024	29542577		cystathionine beta-synthase, putative [C...	316	Conserved; Drug target functions	Phase 3: June 2008	1JBQ	60.9%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP02211 (show subtarget assignments)	1	cloned	No	CBU_2025	29542578	metC	cystathionine beta-lyase [Coxiella burne...	387	Conserved; Drug target functions	Phase 3: June 2008	3E6G	63%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02212 (show subtarget assignments)	1	cloned	No	CBU_2048	29542599	metE	5-methyltetrahydropteroyltriglutamate--h...	775	Conserved; Drug target functions	Phase 3: June 2008	1U1H	48.5%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP91601 (show subtarget assignments)	8	cloned	No	CBU_2052	29542603		hypothetical protein	300	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91602 (show subtarget assignments)	8	expressed	No	CBU_2056	29542607		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91600 (show subtarget assignments)	8	cloned	No	CBU_2059	29542610		hypothetical protein	400	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP00319 (show subtarget assignments)	1	expressed	No	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02257 (show subtarget assignments)	1	expressed	No	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02179 (show subtarget assignments)	1	soluble	No	CBU_2090	29542640	proC	pyrroline-5-carboxylate reductase [Coxie...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	100%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP04031 (show subtarget assignments)	1	cloned	No	CBU_A0011	29648123		hypothetical protein CBUA0011 [Coxiella ...	56	drug target;	Phase 4: April 2009			Coxiella burnetii	Hypothetical proteins	Domain

IDP05096 (show subtarget assignments)	1	cloned	No	CD0015	126697581		putative cytosine/adenosine deaminase [C...	155	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WWR	48.1%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP00301
(show subtarget assignments)

1

expressed

No

CBU_0983

291

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

3NVT

10.7%

Coxiella burnetii

IDP01858
(show subtarget assignments)

1

cloned

No

CBU_0993

29541575

def

peptide deformylase [Coxiella burnetii R...

170

Conserved; Drug target functions

Phase 3: June 2008

1N5N

47.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP02176
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02046
(show subtarget assignments)

1

soluble

No

CBU_1007

29541589

bioB

biotin synthase [Coxiella burnetii RSA 4...

321

Conserved; Drug target functions

Phase 3: June 2008

1R30

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01797
(show subtarget assignments)

1

cloned

No

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02060
(show subtarget assignments)

1

expressed

No

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01805
(show subtarget assignments)

1

soluble

No

CBU_1084

29541658

sensory box sensor histidine kinase/resp...

683

Conserved; Drug target functions

Phase 3: June 2008

2C2A

12.4%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01734
(show subtarget assignments)

1

cloned

No

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP01932
(show subtarget assignments)

1

cloned

No

CBU_1099

29541673

lepB-1

signal peptidase I [Coxiella burnetii RS...

259

Conserved; Drug target functions

Phase 3: June 2008

1T7D

33.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02200
(show subtarget assignments)

1

cloned

No

CBU_1103

29541677

transglycosylase, Slt family [Coxiella b...

425

Conserved; Drug target functions

Phase 3: June 2008

1QSA

16.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91586
(show subtarget assignments)

8

expressed

No

CBU_1107

29541681

hypothetical protein

306

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91587
(show subtarget assignments)

8

expressed

No

CBU_1108

29541682

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01735
(show subtarget assignments)

1

soluble

No

CBU_1129

29541703

nifS

cysteine desulfurase [Coxiella burnetii ...

396

Conserved; Drug target functions

Phase 3: June 2008

1P3W

57.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00300
(show subtarget assignments)

1

cloned

No

CBU_1153

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

1GXB

10.4%

Coxiella burnetii

IDP01921
(show subtarget assignments)

1

expressed

No

CBU_1154

29541726

trpC

indole-3-glycerol phosphate synthase [Co...

257

Conserved; Drug target functions

Phase 3: June 2008

3QJA

37%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00302
(show subtarget assignments)

1

expressed

No

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02019
(show subtarget assignments)

1

cloned

No

CBU_1182

29541752

iscS

cysteine desulfurase [Coxiella burnetii ...

380

Conserved; Drug target functions

Phase 3: June 2008

1P3W

43.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01731
(show subtarget assignments)

1

expressed

No

CBU_1222

29541792

dapA

dihydrodipicolinate synthase [Coxiella b...

289

Conserved; Drug target functions

Phase 3: June 2008

3QZE

55.2%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP02021
(show subtarget assignments)

1

cloned

No

CBU_1240

29541810

gcp

O-sialoglycoprotein endopeptidase [Coxie...

339

Conserved; Drug target functions

Phase 3: June 2008

2IVN

36%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02160
(show subtarget assignments)

1

soluble

No

CBU_1245

29541815

GTP-binding protein [Coxiella burnetii R...

443

Conserved; Drug target functions

Phase 3: June 2008

2HJG

38.4%

Coxiella burnetii

Unknown function

General

IDP02030
(show subtarget assignments)

1

expressed

No

CBU_1255

29541825

geranyltranstransferase, putative [Coxie...

267

Conserved; Drug target functions

Phase 3: June 2008

3TS7

40.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02776
(show subtarget assignments)

1

expressed

No

CBU_1266

29541836

lipA

lipoic acid synthetase [Coxiella burneti...

315

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP02168
(show subtarget assignments)

1

expressed

No

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02646
(show subtarget assignments)

1

expressed

No

CBU_1290

29541858

dnaK

chaperone protein dnak [Coxiella burneti...

656

Conserved; Drug target functions

Phase 3: June 2008

2KHO

68.9%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02284
(show subtarget assignments)

1

soluble

No

CBU_1293

29541861

grpE

heat shock protein GrpE [Coxiella burnet...

204

Conserved; Drug target functions

Phase 3: June 2008

1DKG

35.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02225
(show subtarget assignments)

1

cloned

No

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01743
(show subtarget assignments)

1

purified

No

CBU_1350

29541915

glmM

phosphoglucosamine mutase [Coxiella burn...

446

Conserved; Drug target functions

Phase 3: June 2008

3PDK

44.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02022
(show subtarget assignments)

1

expressed

No

CBU_1351

29541916

folP

dihydropteroate synthase [Coxiella burne...

297

Conserved; Drug target functions

Phase 3: June 2008

3TR9

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP02062
(show subtarget assignments)

1

soluble

No

CBU_1357

29541922

csdB

selenocysteine lyase [Coxiella burnetii ...

405

Conserved; Drug target functions

Phase 3: June 2008

1I29

50.9%

Coxiella burnetii

Central intermediary metabolism

Other

IDP02511
(show subtarget assignments)

1

soluble

No

CBU_1359

29541924

sufC

ABC transporter, ATP-binding protein [Co...

244

Conserved; Drug target functions

Phase 3: June 2008

2D3W

63.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01815
(show subtarget assignments)

1

soluble

No

CBU_1382

29541947

uppS

undecaprenyl diphosphate synthase [Coxie...

237

Conserved; Drug target functions

Phase 3: June 2008

1JP3

49.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02071
(show subtarget assignments)

1

expressed

No

CBU_1388

29541953

map

methionine aminopeptidase, type I [Coxie...

258

Conserved; Drug target functions

Community Interest

1MAT

65.1%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01846
(show subtarget assignments)

1

soluble

No

CBU_1419

29541979

serine hydroxymethyltransferase [Coxiell...

419

Conserved; Drug target functions

Phase 3: June 2008

1DFO

68.5%

Coxiella burnetii

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02270
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1424

29541984

hemB

porphobilinogen synthase [Coxiella burne...

334

Conserved; Drug target functions

Phase 3: June 2008

1W1Z

48.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02682
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1502

29542061

era

GTP-binding protein Era [Coxiella burnet...

295

Conserved; Drug target functions

Phase 3: June 2008

1EGA

51.2%

Coxiella burnetii

Regulatory functions

RNA interactions

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02199
(show subtarget assignments)

1

expressed

No

CBU_1505

29542064

lepA

GTP-binding protein LepA [Coxiella burne...

614

Conserved; Drug target functions

Phase 3: June 2008

3CB4

69.9%

Coxiella burnetii

Unknown function

General

IDP01976
(show subtarget assignments)

1

in_pdb
3K96

Yes

CBU_1518

29542077

gpsA

glycerol-3-phosphate dehydrogenase (NAD+...

332

Conserved; Drug target functions

Phase 3: June 2008

3K96

100%

Coxiella burnetii

Energy metabolism

Other

IDP91609
(show subtarget assignments)

8

cloned

No

CBU_1524

29542083

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91608
(show subtarget assignments)

8

cloned

No

CBU_1525

29542084

hypothetical protein

382

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91606
(show subtarget assignments)

8

expressed

No

CBU_1532

29542091

hypothetical protein

145

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP01691
(show subtarget assignments)

1

cloned

No

CBU_1575

29542135

tolR

tolR protein [Coxiella burnetii RSA 493]...

147

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Other

IDP02540
(show subtarget assignments)

1

cloned

No

CBU_1584

29542144

shaE

monovalent cation/proton antiporter subu...

115

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01853
(show subtarget assignments)

1

cloned

No

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP02378
(show subtarget assignments)

1

cloned

No

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01689
(show subtarget assignments)

1

soluble

No

CBU_1708

29542266

sodB

superoxide dismutase (fe) [Coxiella burn...

193

Conserved; Drug target functions

Phase 3: June 2008

3TQJ

100%

Coxiella burnetii

Cellular processes

Detoxification

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02390
(show subtarget assignments)

1

cloned

No

CBU_1718

29542276

groEL

chaperonin, 60 kDa [Coxiella burnetii RS...

552

Conserved; Drug target functions

Phase 3: June 2008

2EU1

75.5%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01690
(show subtarget assignments)

1

soluble

No

CBU_1719

29542277

groES

chaperonin, 10 kDa [Coxiella burnetii RS...

96

Conserved; Drug target functions

Phase 3: June 2008

3NX6

58.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01659
(show subtarget assignments)

1

crystallized

No

CBU_1739

29542296

tetrapyrrole (Corrin/Porphyrin) methylas...

285

Conserved; Drug target functions

Phase 3: June 2008

3KWP

42.1%

Coxiella burnetii

Unknown function

General

IDP02415
(show subtarget assignments)

1

soluble

No

CBU_1761

29542318

sensory box sensor histidine kinase/resp...

657

Conserved; Drug target functions

Phase 3: June 2008

2C2A

11.6%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP02431
(show subtarget assignments)

1

crystallized

No

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91607
(show subtarget assignments)

8

cloned

No

CBU_1776

29542333

hypothetical protein

181

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01927
(show subtarget assignments)

1

expressed

No

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP02070
(show subtarget assignments)

1

expressed

No

CBU_1809

29542365

ABC transporter, ATP-binding protein [Co...

221

Conserved; Drug target functions

Phase 3: June 2008

1F3O

49.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91604
(show subtarget assignments)

8

cloned

No

CBU_1823

29542379

hypothetical protein

349

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91605
(show subtarget assignments)

8

cloned

No

CBU_1825

29542381

hypothetical protein

115

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP02675
(show subtarget assignments)

1

expressed

No

CBU_1842

29542398

GTP-binding protein YchF [Coxiella burne...

363

Conserved; Drug target functions

Phase 3: June 2008

1JAL

65.3%

Coxiella burnetii

Unknown function

General

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01624
(show subtarget assignments)

1

expressed

No

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01985
(show subtarget assignments)

1

expressed

No

CBU_1882

29542439

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

435

Conserved; Drug target functions

Phase 3: June 2008

4E77

60.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04631
(show subtarget assignments)

1

cloned

No

CBU_1891

215919282

pilQ

type II and III secretion system family ...

353

conserved gene;

Phase 4: April 2009

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02159
(show subtarget assignments)

1

cloned

No

CBU_1892

29542449

aroK

shikimate kinase [Coxiella burnetii RSA ...

179

Conserved; Drug target functions

Phase 3: June 2008

3TRF

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02604
(show subtarget assignments)

1

expressed

No

CBU_1893

29542450

aroB

3-dehydroquinate synthase [Coxiella burn...

360

Conserved; Drug target functions

Phase 3: June 2008

3OKF

48.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01700
(show subtarget assignments)

1

expressed

No

CBU_1899

29542456

methyltransferase, putative [Coxiella bu...

193

Conserved; Drug target functions

Phase 3: June 2008

2FPO

51%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP01629
(show subtarget assignments)

1

cloned

No

CBU_1903

29542460

ftsY

signal recognition particle-docking prot...

324

Conserved; Drug target functions

Phase 3: June 2008

2YHS

58%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02371
(show subtarget assignments)

1

expressed

No

CBU_1904

29542461

ftsE

cell division ABC transporter, ATP-bindi...

217

Conserved; Drug target functions

Phase 3: June 2008

1F3O

38.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01628
(show subtarget assignments)

1

cloned

No

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91603
(show subtarget assignments)

8

cloned

No

CBU_1963

29542518

hypothetical protein

633

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01630
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1964

29542519

hemK

protein methyltransferase HemK [Coxiella...

277

Conserved; Drug target functions

Phase 3: June 2008

1T43

42.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP02522
(show subtarget assignments)

1

expressed

No

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP02165
(show subtarget assignments)

1

soluble

No

CBU_1993

29542548

folA

dihydrofolate reductase [Coxiella burnet...

161

Conserved; Drug target functions

Phase 3: June 2008

3TQ8

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04632
(show subtarget assignments)

1

cloned

No

CBU_2005

29655288

rstB

signal transduction histidine kinase-lik...

425

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.2%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP01995
(show subtarget assignments)

1

soluble

No

CBU_2012

29542567

hslU

heat shock protein HslVU, ATPase subunit...

447

Conserved; Drug target functions

Phase 3: June 2008

1DO0

67.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02069
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_2017

29542571

ubiE

ubiquinone/menaquinone biosynthesis meth...

250

Conserved; Drug target functions

Phase 3: June 2008

3SM3

19.6%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01631
(show subtarget assignments)

1

soluble

No

CBU_2024

29542577

cystathionine beta-synthase, putative [C...

316

Conserved; Drug target functions

Phase 3: June 2008

1JBQ

60.9%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP02211
(show subtarget assignments)

1

cloned

No

CBU_2025

29542578

metC

cystathionine beta-lyase [Coxiella burne...

387

Conserved; Drug target functions

Phase 3: June 2008

3E6G

63%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02212
(show subtarget assignments)

1

cloned

No

CBU_2048

29542599

metE

5-methyltetrahydropteroyltriglutamate--h...

775

Conserved; Drug target functions

Phase 3: June 2008

1U1H

48.5%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP91601
(show subtarget assignments)

8

cloned

No

CBU_2052

29542603

hypothetical protein

300

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91602
(show subtarget assignments)

8

expressed

No

CBU_2056

29542607

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91600
(show subtarget assignments)

8

cloned

No

CBU_2059

29542610

hypothetical protein

400

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP00319
(show subtarget assignments)

1

expressed

No

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02257
(show subtarget assignments)

1

expressed

No

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02179
(show subtarget assignments)

1

soluble

No

CBU_2090

29542640

proC

pyrroline-5-carboxylate reductase [Coxie...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

100%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP04031
(show subtarget assignments)

1

cloned

No

CBU_A0011

29648123

hypothetical protein CBUA0011 [Coxiella ...

56

drug target;

Phase 4: April 2009

Coxiella burnetii

Hypothetical proteins

Domain

IDP05096
(show subtarget assignments)

1

cloned

No

CD0015

126697581

putative cytosine/adenosine deaminase [C...

155

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WWR

48.1%

Clostridium difficile

Transport and binding proteins: Unknown substrate