Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05455 (show subtarget assignments)	1	soluble	No	BA_0223	30253724		conserved hypothetical protein [Bacillus...	549	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP91611 (show subtarget assignments)	8	expressed	No	BAB37278	13363327	ECs3855	putative enterotoxin [Escherichia coli O...	549	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP02113 (show subtarget assignments)	1	in_crystallization_trials	No	STM3901	16767177	ilvG	acetolactate synthase 2 catalytic subuni...	548	Conserved; Drug target functions	Phase 3: June 2008	1YBH	46.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP01485 (show subtarget assignments)	1	soluble	No	VCA0220	15600989		hemolysin secretion protein HylB	548	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	16.4%	Vibrio cholerae	Transport and binding proteins	Other

IDP01665 (show subtarget assignments)	1	soluble	No	YPO3001	16123182		putative pyridine nucleotide-disulphide ...	548	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	3ICR	58%	Yersinia pestis	Cellular processes	Detoxification

IDP00428 (show subtarget assignments)	1	expressed	No	YPO2355	16122579	sapA	peptide transport periplasmic protein pr...	548	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	36.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05423 (show subtarget assignments)	1	cloned	No	lmo0263	16802309	inlH	internalin H [Listeria monocytogenes EGD...	548	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H6U	55.7%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP90758 (show subtarget assignments)	8	cloned	No	VC1149	15641162		glutamate decarboxylase, putative [Vibri...	548	Predicted Essential	Community Requests	2OKJ	26.1%	Vibrio cholerae

IDP00305 (show subtarget assignments)	1	cloned	No	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01175 (show subtarget assignments)	1	expressed	No	BA_2825	30257427		peptidase M3 family protein	548	Drug Target Function	Phase 2: March 2008	3CE2	22.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00133 (show subtarget assignments)	1	purified	No	VC_2095	9656644	VC2095	Vibrio cholerae O1 biovar eltor str. N16...	548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2FUV	70.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP00300 (show subtarget assignments)	1	cloned	No	CBU_1153				548	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	1GXB	10.4%	Coxiella burnetii

IDP00556 (show subtarget assignments)	1	cloned	No	YPO2686	16122891	pgm	phosphoglucomutase	547	Drug Target Function	Phase 2: March 2008	2FUV	82.4%	Yersinia pestis	Energy metabolism	Sugars

IDP01047 (show subtarget assignments)	1	cloned	No	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	34.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP04179 (show subtarget assignments)	1	cloned	No	VCA0068	15600839		methyl-accepting chemotaxis protein [Vib...	547	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3ZX6	18.3%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP01694 (show subtarget assignments)	1	purified	No	YPO3335	16123488	fumA	fumarate hydratase, class I [Yersinia pe...	547	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2ISB	10.1%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02090 (show subtarget assignments)	1	cloned	No	STM3577	16766863	tcp	methyl-accepting transmembrane citrate/p...	547	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	40%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01752 (show subtarget assignments)	1	selected	No	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01084 (show subtarget assignments)	1	purified	No	STM4377	161353573	aidB	putative acyl-CoA dehydrogenase	546	Conserved Gene / Pathway	Phase 2: March 2008	3DJL	84.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP92101 (show subtarget assignments)	8	selected	No	TGME49_032340	237837613		protein phosphatase 2C, putative [Toxopl...	546	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2I0O	17.9%	Toxoplasma gondii

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP05149 (show subtarget assignments)	1	purified	No	BA_0194	30253701		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	30.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05150 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0195	30253702		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90914 (show subtarget assignments)	8	purified	No	YPO2710	16122914	nadB	L-aspartate oxidase [Yersinia pestis CO9...	545	Predicted Essential	Community Requests	1CHU	82%	Yersinia pestis

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00074 (show subtarget assignments)	0	work_stopped	No	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02266 (show subtarget assignments)	1	purified	No	Cj0043	15791442	flgE	flagellar hook protein [Campylobacter je...	545	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	3A69	25.6%	Campylobacter jejuni	Cell envelope	Surface structures

IDP01975 (show subtarget assignments)	1	cloned	No	Cj1442c	15792760		hypothetical protein Cj1442c [Campylobac...	544	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2FFU	10.5%	Campylobacter jejuni	Central intermediary metabolism	Other

IDP05147 (show subtarget assignments)	1	cloned	No	BAS4903	49187891	-	methionyl-tRNA synthetase [Bacillus anth...	544	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RQG	38.7%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP02183 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0414	56707563	pgm	phosphoglucomutase [Francisella tularens...	544	Drug Target	Phase 3: June 2008	1C47	54.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02516 (show subtarget assignments)	1	purified	No	FTT1696	56708705	groEL	chaperonin GroEL [Francisella tularensis...	544	Conserved; Drug target functions	Phase 3: June 2008	1AON	73.3%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01184 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0267	41016866		60 kDa chaperonin (Protein Cpn60) (groEL...	544	Conserved Gene / Pathway	Phase 2: March 2008	1WE3	67.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP00065 (show subtarget assignments)	1	expressed	No	BA_5409	30259882		macrolide efflux pump, putative	544	Virulence	Phase 1: October 2007	1YQT	24.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP92104 (show subtarget assignments)	8	selected	No	TGME49_026400	237833991		lipoic acid synthase [Toxoplasma gondii ...	543	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP05157 (show subtarget assignments)	1	soluble	No	BA_1191	30254904		oligopeptide ABC transporter, oligopepti...	543	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90808 (show subtarget assignments)	8	selected	No	YPO3779	16123913	ubiB	putative ubiquinone biosynthesis protein...	543	Predicted Essential	Community Requests			Yersinia pestis

IDP01400 (show subtarget assignments)	1	expressed	No	VC0772	15640791		vibriobactin-specific 2,3-dihydroxybenzo...	543	Conserved Gene / Pathway	Phase 2: March 2008	1MD9	51.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01410 (show subtarget assignments)	1	in_crystallization_trials	No	VC1091	15641104		oligopeptide ABC transporter, periplasmi...	543	Conserved Gene / Pathway	Phase 2: March 2008	2Z23	53.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP92561 (show subtarget assignments)	8	selected	No	3EQV_A	209870568		Chain A, Crystal Structure Of Penicillin...	542	potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...	Community Requests	3EQV	99.8%	Neisseria gonorrhoeae

IDP00034 (show subtarget assignments)	1	expressed	No	BA_1346	30255285		internalin, putative	542	Virulence	Phase 1: October 2007	2OMT	21.6%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00549 (show subtarget assignments)	1	purified	No	YPO3814	16123948	ftsY	cell division protein	541	Conserved Gene / Pathway	Phase 2: March 2008	2YHS	63.7%	Yersinia pestis	Cellular processes	Cell division

IDP01940 (show subtarget assignments)	1	cloned	No	STM1626	16764970	trg	methyl-accepting chemotaxis protein III ...	541	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	35.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP04597 (show subtarget assignments)	1	expressed	No	BAS1384	49184401		resB protein [Bacillus anthracis str. St...	541	Proposed to be essential proteins	Phase 4: April 2009			Bacillus anthracis

IDP91214 (show subtarget assignments)	8	expressed	No	Blon_1597	189439474	aroB	bifunctional shikimate kinase/3-dehydroq...	540	potential drug target / Shikimate pathway enzyme	Community Requests	3QBD	32.6%	Bifidobacterium longum

IDP02733 (show subtarget assignments)	1	in_pdb 3M5P 3Q7I 3Q88 3LJK	Yes	FTT1315c	56708372	pgi	glucose-6-phosphate isomerase [Francisel...	540	Conserved; Drug target functions	Phase 3: June 2008	3LJK	99.8%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP90868 (show subtarget assignments)	8	in_crystallization_trials	No	YPO2912	16123101	nadE	NAD synthetase [Yersinia pestis CO92]	540	Predicted Essential	Community Requests	3N05	44.6%	Yersinia pestis

IDP05319 (show subtarget assignments)	1	soluble	No	BA_2848	30257448		putative oligopeptide ABC transporter, o...	540	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z23	29.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP91825 (show subtarget assignments)	8	expressed	No	b3403	1789807	pck	phosphoenolpyruvate carboxykinase [Esche...	540	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1AQ2	100%	Escherichia coli

IDP04356 (show subtarget assignments)	1	cloned	No	YPO0509	115346318		hypothetical protein [Yersinia pestis CO...	540	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2XT4	9.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90902 (show subtarget assignments)	8	in_crystallization_trials	No	STM2641	16765961	nadB	L-aspartate oxidase [Salmonella typhimur...	540	Predicted Essential	Community Requests	1CHU	89.6%	Salmonella enterica

IDP90389 (show subtarget assignments)	8	cloned	No	CT_384	3328809		hypothetical protein [Chlamydia trachoma...	539	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05553 (show subtarget assignments)	1	soluble	No	lmo1136	16803176	-	hypothetical protein lmo1136 [Listeria m...	539	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.6%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01986 (show subtarget assignments)	1	soluble	No	YPO0138	16120481	pckA	phosphoenolpyruvate carboxykinase [Yersi...	539	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1AQ2	87.2%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP91964 (show subtarget assignments)	8	purified	No	SpneCM_010100007935	298255513		ABC transporter, substrate-binding prote...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3OMB	28.4%	Streptococcus pneumoniae

IDP04676 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04223 (show subtarget assignments)	8	selected	No	CAC05808	12329077	ipgD	IpgD, secreted by the Mxi-Spa machinery,...	538	Shigella effector protein	Community Requests			Shigella flexneri

IDP91695 (show subtarget assignments)	8	selected	No	NP_002255	222144293	KPNA1	importin subunit alpha-1 [Homo sapiens]	538	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3TJ3	83.1%	Homo sapiens

IDP91940 (show subtarget assignments)	8	selected	No	SpneCM_010100006879	298255307		ABC transporter, ATP-binding protein [St...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	25.4%	Streptococcus pneumoniae

IDP00685 (show subtarget assignments)	1	purified	No	SACOL2016	57284887	groEL	chaperonin GroEL	538	Drug Target Function	Phase 2: March 2008	3RTK	59.3%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP91980 (show subtarget assignments)	8	selected	No	SpneCM_010100004697	298254896		hypothetical protein SpneCM_04697 [Strep...	537	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP01959 (show subtarget assignments)	1	soluble	No	STM1679	16765022	mppA	periplasmic murein tripeptide transport ...	537	Conserved; Drug target functions	Phase 3: June 2008	3O9P	89.2%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP04712 (show subtarget assignments)	1	cloned	No	YPO0514	115346324		putative OmpA-family membrane protein [Y...	536	virulence factor; putative drug target function;	Phase 4: April 2009	2L26	9%	Yersinia pestis	Cell envelope	Other

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP02546 (show subtarget assignments)	1	expressed	No	Cj1143	15792468	neuA1	acylneuraminate cytidylyltransferase [Ca...	536	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1EYR	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90339 (show subtarget assignments)	8	cloned	No	CT050	15604769		hypothetical protein CT050 [Chlamydia tr...	536	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3H0G	10.8%	Chlamydia trachomatis

IDP02607 (show subtarget assignments)	1	expressed	No	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP05166 (show subtarget assignments)	1	soluble	No	BA_1921	30256579		amidase family protein [Bacillus anthrac...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	36%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP92110 (show subtarget assignments)	8	selected	No	TGME49_001380	237836313		chorismate synthase, putative [Toxoplasm...	536	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1R52	36.9%	Toxoplasma gondii

IDP92067 (show subtarget assignments)	8	selected	No	TGME49_069430	237832673		hexaprenyl pyrophosphate synthetase prot...	536	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3APZ	23.9%	Toxoplasma gondii

IDP05713 (show subtarget assignments)	1	cloned	No	BA_0189	30253696		oligopeptide ABC transporter, oligopepti...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90502 (show subtarget assignments)	8	purified	No	Q9KPA4	22653875		RecName: Full=L-aspartate oxidase; Short...	535	Predicted Essential	Community Requests	1CHU	75.3%	Vibrio cholerae

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP91315 (show subtarget assignments)	8	expressed	No	VV2_0482	27366916		ABC-type bacteriocin/lantibiotic exporte...	535	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HYD	32.7%	Vibrio vulnificus

IDP01868 (show subtarget assignments)	1	cloned	No	GBAA5583	47530904	ctrA	CTP synthetase [Bacillus anthracis str. ...	535	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1S1M	56.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04158 (show subtarget assignments)	1	expressed	No	VC1088	15641101		sensor histidine kinase [Vibrio cholerae...	534	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3D36	13.5%	Vibrio cholerae	Regulatory functions	Other

IDP91055 (show subtarget assignments)	8	cloned	No	NP_818933	29611985		nonstructural protein nsP1 [Western equi...	533	potential drug target / A structure of the nsP1 from Western Equine encephalitis virus (WEEV) nonstructu...	Community Requests			Western equine

IDP00322 (show subtarget assignments)	1	expressed	No	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP90950 (show subtarget assignments)	8	soluble	No	ZZZ_0018	51094326	MAPK-1	mitogen-activated protein kinase 1	532	Drug Target Homolog	Community Requests	3OHT	30.1%	Toxoplasma gondii

IDP02426 (show subtarget assignments)	1	cloned	No	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP05158 (show subtarget assignments)	1	cloned	No	BA_1197	30255150		oligopeptide ABC transporter, oligopepti...	532	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3O9P	29.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP91233 (show subtarget assignments)	8	expressed	No	NT04EC1775	26107994	trpD	Anthranilate synthase component II [Esch...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91301 (show subtarget assignments)	8	expressed	No	STM1724	16765068	trpD	anthranilate phosphoribosyltransferase	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.1%	Salmonella enterica

IDP00487 (show subtarget assignments)	1	purified	No	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP91288 (show subtarget assignments)	8	soluble	No	SPA1153	56413351	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Salmonella enterica

IDP91224 (show subtarget assignments)	8	cloned	No	SF1266	24112662	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	46.7%	Shigella flexneri

IDP02482 (show subtarget assignments)	1	expressed	No	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01497 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0820	15601575	groEL	chaperonin GroEL	530	Conserved Gene / Pathway	Phase 2: March 2008	1AON	74.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP91451 (show subtarget assignments)	8	expressed	No	VV1_0382	27363851		ATP-dependent endonuclease [Vibrio vulni...	530	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02705 (show subtarget assignments)	1	cloned	No	lmo0202	16802248	hly	listeriolysin O precursor [Listeria mono...	529	Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162	Phase 3: June 2008	3HVN	41%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05043 (show subtarget assignments)	1	soluble	No	BA_3162	30257734		putative 5'-nucleotidase [Bacillus anthr...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05499 (show subtarget assignments)	1	soluble	No	BA_4322	30258823		5'-nucleotidase family protein [Bacillus...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.2%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91646 (show subtarget assignments)	8	purified	No	NP_217928	15610547		inosine 5'-monophosphate dehydrogenase [...	529	drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...	Community Requests	3TSB	50.3%	Mycobacterium tuberculosis

IDP05030 (show subtarget assignments)	1	soluble	No	BA_0898	30254646		N-acetylmuramoyl-L-alanine amidase, fami...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	18.1%	Bacillus anthracis	Cell envelope: Surface structures

IDP90948 (show subtarget assignments)	8	cloned	No	M5005_Spy_1720	71911533	mga	trans-acting positive regulator [Strepto...	529	The multiple gene regulator of the Group A Streptococcus (Mga) is an established...	Community Requests			Streptococcus pyogenes

IDP05031 (show subtarget assignments)	1	soluble	No	BA_0908	30254654		oligopeptide ABC transporter, oligopepti...	528	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	30.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05455
(show subtarget assignments)

1

soluble

No

BA_0223

30253724

conserved hypothetical protein [Bacillus...

549

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP91611
(show subtarget assignments)

8

expressed

No

BAB37278

13363327

ECs3855

putative enterotoxin [Escherichia coli O...

549

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP02113
(show subtarget assignments)

1

in_crystallization_trials

No

STM3901

16767177

ilvG

acetolactate synthase 2 catalytic subuni...

548

Conserved; Drug target functions

Phase 3: June 2008

1YBH

46.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP01485
(show subtarget assignments)

1

soluble

No

VCA0220

15600989

hemolysin secretion protein HylB

548

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

16.4%

Vibrio cholerae

Transport and binding proteins

Other

IDP01665
(show subtarget assignments)

1

soluble

No

YPO3001

16123182

putative pyridine nucleotide-disulphide ...

548

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

3ICR

58%

Yersinia pestis

Cellular processes

Detoxification

IDP00428
(show subtarget assignments)

1

expressed

No

YPO2355

16122579

sapA

peptide transport periplasmic protein pr...

548

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

36.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP05423
(show subtarget assignments)

1

cloned

No

lmo0263

16802309

inlH

internalin H [Listeria monocytogenes EGD...

548

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H6U

55.7%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP90758
(show subtarget assignments)

8

cloned

No

VC1149

15641162

glutamate decarboxylase, putative [Vibri...

548

Predicted Essential

Community Requests

2OKJ

26.1%

Vibrio cholerae

IDP00305
(show subtarget assignments)

1

cloned

No

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01175
(show subtarget assignments)

1

expressed

No

BA_2825

30257427

peptidase M3 family protein

548

Drug Target Function

Phase 2: March 2008

3CE2

22.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00133
(show subtarget assignments)

1

purified

No

VC_2095

9656644

VC2095

Vibrio cholerae O1 biovar eltor str. N16...

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2FUV

70.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP00300
(show subtarget assignments)

1

cloned

No

CBU_1153

548

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

1GXB

10.4%

Coxiella burnetii

IDP00556
(show subtarget assignments)

1

cloned

No

YPO2686

16122891

pgm

phosphoglucomutase

547

Drug Target Function

Phase 2: March 2008

2FUV

82.4%

Yersinia pestis

Energy metabolism

Sugars

IDP01047
(show subtarget assignments)

1

cloned

No

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

34.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP04179
(show subtarget assignments)

1

cloned

No

VCA0068

15600839

methyl-accepting chemotaxis protein [Vib...

547

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3ZX6

18.3%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP01694
(show subtarget assignments)

1

purified

No

YPO3335

16123488

fumA

fumarate hydratase, class I [Yersinia pe...

547

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2ISB

10.1%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02090
(show subtarget assignments)

1

cloned

No

STM3577

16766863

tcp

methyl-accepting transmembrane citrate/p...

547

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

40%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01752
(show subtarget assignments)

1

selected

No

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01084
(show subtarget assignments)

1

purified

No

STM4377

161353573

aidB

putative acyl-CoA dehydrogenase

546

Conserved Gene / Pathway

Phase 2: March 2008

3DJL

84.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP92101
(show subtarget assignments)

8

selected

No

TGME49_032340

237837613

protein phosphatase 2C, putative [Toxopl...

546

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2I0O

17.9%

Toxoplasma gondii

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP05149
(show subtarget assignments)

1

purified

No

BA_0194

30253701

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

30.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05150
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0195

30253702

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90914
(show subtarget assignments)

8

purified

No

YPO2710

16122914

nadB

L-aspartate oxidase [Yersinia pestis CO9...

545

Predicted Essential

Community Requests

1CHU

82%

Yersinia pestis

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00074
(show subtarget assignments)

0

work_stopped

No

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02266
(show subtarget assignments)

1

purified

No

Cj0043

15791442

flgE

flagellar hook protein [Campylobacter je...

545

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

3A69

25.6%

Campylobacter jejuni

Cell envelope

Surface structures

IDP01975
(show subtarget assignments)

1

cloned

No

Cj1442c

15792760

hypothetical protein Cj1442c [Campylobac...

544

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2FFU

10.5%

Campylobacter jejuni

Central intermediary metabolism

Other

IDP05147
(show subtarget assignments)

1

cloned

No

BAS4903

49187891

-

methionyl-tRNA synthetase [Bacillus anth...

544

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RQG

38.7%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP02183
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0414

56707563

pgm

phosphoglucomutase [Francisella tularens...

544

Drug Target

Phase 3: June 2008

1C47

54.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02516
(show subtarget assignments)

1

purified

No

FTT1696

56708705

groEL

chaperonin GroEL [Francisella tularensis...

544

Conserved; Drug target functions

Phase 3: June 2008

1AON

73.3%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01184
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0267

41016866

60 kDa chaperonin (Protein Cpn60) (groEL...

544

Conserved Gene / Pathway

Phase 2: March 2008

1WE3

67.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP00065
(show subtarget assignments)

1

expressed

No

BA_5409

30259882

macrolide efflux pump, putative

544

Virulence

Phase 1: October 2007

1YQT

24.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP92104
(show subtarget assignments)

8

selected

No

TGME49_026400

237833991

lipoic acid synthase [Toxoplasma gondii ...

543

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP05157
(show subtarget assignments)

1

soluble

No

BA_1191

30254904

oligopeptide ABC transporter, oligopepti...

543

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90808
(show subtarget assignments)

8

selected

No

YPO3779

16123913

ubiB

putative ubiquinone biosynthesis protein...

543

Predicted Essential

Community Requests

Yersinia pestis

IDP01400
(show subtarget assignments)

1

expressed

No

VC0772

15640791

vibriobactin-specific 2,3-dihydroxybenzo...

543

Conserved Gene / Pathway

Phase 2: March 2008

1MD9

51.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01410
(show subtarget assignments)

1

in_crystallization_trials

No

VC1091

15641104

oligopeptide ABC transporter, periplasmi...

543

Conserved Gene / Pathway

Phase 2: March 2008

2Z23

53.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP92561
(show subtarget assignments)

8

selected

No

3EQV_A

209870568

Chain A, Crystal Structure Of Penicillin...

542

potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...

Community Requests

3EQV

99.8%

Neisseria gonorrhoeae

IDP00034
(show subtarget assignments)

1

expressed

No

BA_1346

30255285

internalin, putative

542

Virulence

Phase 1: October 2007

2OMT

21.6%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00549
(show subtarget assignments)

1

purified

No

YPO3814

16123948

ftsY

cell division protein

541

Conserved Gene / Pathway

Phase 2: March 2008

2YHS

63.7%

Yersinia pestis

Cellular processes

Cell division

IDP01940
(show subtarget assignments)

1

cloned

No

STM1626

16764970

trg

methyl-accepting chemotaxis protein III ...

541

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

35.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP04597
(show subtarget assignments)

1

expressed

No

BAS1384

49184401

resB protein [Bacillus anthracis str. St...

541

Proposed to be essential proteins

Phase 4: April 2009

Bacillus anthracis

IDP91214
(show subtarget assignments)

8

expressed

No

Blon_1597

189439474

aroB

bifunctional shikimate kinase/3-dehydroq...

540

potential drug target / Shikimate pathway enzyme

Community Requests

3QBD

32.6%

Bifidobacterium longum

IDP02733
(show subtarget assignments)

1

in_pdb
3M5P
3Q7I
3Q88
3LJK

Yes

FTT1315c

56708372

pgi

glucose-6-phosphate isomerase [Francisel...

540

Conserved; Drug target functions

Phase 3: June 2008

3LJK

99.8%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP90868
(show subtarget assignments)

8

in_crystallization_trials

No

YPO2912

16123101

nadE

NAD synthetase [Yersinia pestis CO92]

540

Predicted Essential

Community Requests

3N05

44.6%

Yersinia pestis

IDP05319
(show subtarget assignments)

1

soluble

No

BA_2848

30257448

putative oligopeptide ABC transporter, o...

540

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z23

29.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP91825
(show subtarget assignments)

8

expressed

No

b3403

1789807

pck

phosphoenolpyruvate carboxykinase [Esche...

540

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1AQ2

100%

Escherichia coli

IDP04356
(show subtarget assignments)

1

cloned

No

YPO0509

115346318

hypothetical protein [Yersinia pestis CO...

540

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2XT4

9.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90902
(show subtarget assignments)

8

in_crystallization_trials

No

STM2641

16765961

nadB

L-aspartate oxidase [Salmonella typhimur...

540

Predicted Essential

Community Requests

1CHU

89.6%

Salmonella enterica

IDP90389
(show subtarget assignments)

8

cloned

No

CT_384

3328809

hypothetical protein [Chlamydia trachoma...

539

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05553
(show subtarget assignments)

1

soluble

No

lmo1136

16803176

-

hypothetical protein lmo1136 [Listeria m...

539

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.6%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01986
(show subtarget assignments)

1

soluble

No

YPO0138

16120481

pckA

phosphoenolpyruvate carboxykinase [Yersi...

539

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1AQ2

87.2%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP91964
(show subtarget assignments)

8

purified

No

SpneCM_010100007935

298255513

ABC transporter, substrate-binding prote...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3OMB

28.4%

Streptococcus pneumoniae

IDP04676
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04223
(show subtarget assignments)

8

selected

No

CAC05808

12329077

ipgD

IpgD, secreted by the Mxi-Spa machinery,...

538

Shigella effector protein

Community Requests

Shigella flexneri

IDP91695
(show subtarget assignments)

8

selected

No

NP_002255

222144293

KPNA1

importin subunit alpha-1 [Homo sapiens]

538

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3TJ3

83.1%

Homo sapiens

IDP91940
(show subtarget assignments)

8

selected

No

SpneCM_010100006879

298255307

ABC transporter, ATP-binding protein [St...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

25.4%

Streptococcus pneumoniae

IDP00685
(show subtarget assignments)

1

purified

No

SACOL2016

57284887

groEL

chaperonin GroEL

538

Drug Target Function

Phase 2: March 2008

3RTK

59.3%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP91980
(show subtarget assignments)

8

selected

No

SpneCM_010100004697

298254896

hypothetical protein SpneCM_04697 [Strep...

537

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP01959
(show subtarget assignments)

1

soluble

No

STM1679

16765022

mppA

periplasmic murein tripeptide transport ...

537

Conserved; Drug target functions

Phase 3: June 2008

3O9P

89.2%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP04712
(show subtarget assignments)

1

cloned

No

YPO0514

115346324

putative OmpA-family membrane protein [Y...

536

virulence factor; putative drug target function;

Phase 4: April 2009

2L26

9%

Yersinia pestis

Cell envelope

Other

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP02546
(show subtarget assignments)

1

expressed

No

Cj1143

15792468

neuA1

acylneuraminate cytidylyltransferase [Ca...

536

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1EYR

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90339
(show subtarget assignments)

8

cloned

No

CT050

15604769

hypothetical protein CT050 [Chlamydia tr...

536

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3H0G

10.8%

Chlamydia trachomatis

IDP02607
(show subtarget assignments)

1

expressed

No

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP05166
(show subtarget assignments)

1

soluble

No

BA_1921

30256579

amidase family protein [Bacillus anthrac...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

36%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP92110
(show subtarget assignments)

8

selected

No

TGME49_001380

237836313

chorismate synthase, putative [Toxoplasm...

536

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1R52

36.9%

Toxoplasma gondii

IDP92067
(show subtarget assignments)

8

selected

No

TGME49_069430

237832673

hexaprenyl pyrophosphate synthetase prot...

536

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3APZ

23.9%

Toxoplasma gondii

IDP05713
(show subtarget assignments)

1

cloned

No

BA_0189

30253696

oligopeptide ABC transporter, oligopepti...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90502
(show subtarget assignments)

8

purified

No

Q9KPA4

22653875

RecName: Full=L-aspartate oxidase; Short...

535

Predicted Essential

Community Requests

1CHU

75.3%

Vibrio cholerae

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP91315
(show subtarget assignments)

8

expressed

No

VV2_0482

27366916

ABC-type bacteriocin/lantibiotic exporte...

535

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HYD

32.7%

Vibrio vulnificus

IDP01868
(show subtarget assignments)

1

cloned

No

GBAA5583

47530904

ctrA

CTP synthetase [Bacillus anthracis str. ...

535

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1S1M

56.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04158
(show subtarget assignments)

1

expressed

No

VC1088

15641101

sensor histidine kinase [Vibrio cholerae...

534

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3D36

13.5%

Vibrio cholerae

Regulatory functions

Other

IDP91055
(show subtarget assignments)

8

cloned

No

NP_818933

29611985

nonstructural protein nsP1 [Western equi...

533

potential drug target / A structure of the nsP1 from Western Equine encephalitis virus (WEEV) nonstructu...

Community Requests

Western equine

IDP00322
(show subtarget assignments)

1

expressed

No

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP90950
(show subtarget assignments)

8

soluble

No

ZZZ_0018

51094326

MAPK-1

mitogen-activated protein kinase 1

532

Drug Target Homolog

Community Requests

3OHT

30.1%

Toxoplasma gondii

IDP02426
(show subtarget assignments)

1

cloned

No

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP05158
(show subtarget assignments)

1

cloned

No

BA_1197

30255150

oligopeptide ABC transporter, oligopepti...

532

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3O9P

29.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP91233
(show subtarget assignments)

8

expressed

No

NT04EC1775

26107994

trpD

Anthranilate synthase component II [Esch...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91301
(show subtarget assignments)

8

expressed

No

STM1724

16765068

trpD

anthranilate phosphoribosyltransferase

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.1%

Salmonella enterica

IDP00487
(show subtarget assignments)

1

purified

No

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP91288
(show subtarget assignments)

8

soluble

No

SPA1153

56413351

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Salmonella enterica

IDP91224
(show subtarget assignments)

8

cloned

No

SF1266

24112662

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

46.7%

Shigella flexneri

IDP02482
(show subtarget assignments)

1

expressed

No

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01497
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0820

15601575

groEL

chaperonin GroEL

530

Conserved Gene / Pathway

Phase 2: March 2008

1AON

74.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP91451
(show subtarget assignments)

8

expressed

No

VV1_0382

27363851

ATP-dependent endonuclease [Vibrio vulni...

530

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02705
(show subtarget assignments)

1

cloned

No

lmo0202

16802248

hly

listeriolysin O precursor [Listeria mono...

529

Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162

Phase 3: June 2008

3HVN

41%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05043
(show subtarget assignments)

1

soluble

No

BA_3162

30257734

putative 5'-nucleotidase [Bacillus anthr...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05499
(show subtarget assignments)

1

soluble

No

BA_4322

30258823

5'-nucleotidase family protein [Bacillus...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.2%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91646
(show subtarget assignments)

8

purified

No

NP_217928

15610547

inosine 5'-monophosphate dehydrogenase [...

529

drug target / Potentially essential based on the transposon mutagenesis studies of Sassetti, C...

Community Requests

3TSB

50.3%

Mycobacterium tuberculosis

IDP05030
(show subtarget assignments)

1

soluble

No

BA_0898

30254646

N-acetylmuramoyl-L-alanine amidase, fami...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

18.1%

Bacillus anthracis

Cell envelope: Surface structures

IDP90948
(show subtarget assignments)

8

cloned

No

M5005_Spy_1720

71911533

mga

trans-acting positive regulator [Strepto...

529

The multiple gene regulator of the Group A Streptococcus (Mga) is an established...

Community Requests

Streptococcus pyogenes

IDP05031
(show subtarget assignments)

1

soluble

No

BA_0908

30254654

oligopeptide ABC transporter, oligopepti...

528

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

30.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines