Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01492 (show subtarget assignments)	1	purified	No	VCA0702	15601458		iron-containing alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1OJ7	50.8%	Vibrio cholerae	Energy metabolism	Fermentation

IDP00419 (show subtarget assignments)	1	purified	No	YPO0678	16121001		putative iron-containing alcohol dehydro...	385	Drug Target Function	Phase 2: March 2008	1OJ7	76.7%	Yersinia pestis	Central intermediary metabolism	Other

IDP00031 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1078	30254808	blaI	penicillinase repressor	132	Virulence	Phase 1: October 2007	1OKR	35.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01993 (show subtarget assignments)	1	cloned	No	lmo1476	16803516	hemN	coproporphyrinogen III oxidase [Listeria...	385	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	27.4%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05210 (show subtarget assignments)	1	cloned	No	CD2464	126700081	hemN	oxygen-independent coproporphyrinogen II...	380	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1OLT	20.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02195 (show subtarget assignments)	1	expressed	No	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02138 (show subtarget assignments)	1	expressed	No	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02134 (show subtarget assignments)	1	soluble	No	CBU_0597	29541198		oxygen-independent coproporphyrinogen II...	375	Conserved; Drug target functions	Phase 3: June 2008	1OLT	20.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01088 (show subtarget assignments)	1	expressed	No	STM4512	16767756	iadA	isoaspartyl dipeptidase	390	Drug Target Function	Phase 2: March 2008	1ONX	81%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP91281 (show subtarget assignments)	8	expressed	No	NT05BA5437	49182125		RNA polymerase sigma-70 factor, ECF subf...	175	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1OR7	22.5%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP90290 (show subtarget assignments)	8	purified	No	TGME49_019520	211968370		arginine N-methyltransferase 1 [Toxoplas...	392	The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...	Community Requests	1OR8	44.9%	Toxoplasma gondii

IDP90528 (show subtarget assignments)	8	cloned	No	VCA1063	15601814		ornithine decarboxylase [Vibrio cholerae...	720	Predicted Essential	Community Requests	1ORD	59.1%	Vibrio cholerae

IDP01045 (show subtarget assignments)	1	soluble	No	STM3114	16766415	speC	ornithine decarboxylase isozyme	711	Conserved Gene / Pathway	Phase 2: March 2008	1ORD	53.8%	Salmonella enterica	Central intermediary metabolism	Polyamine biosynthesis

IDP90997 (show subtarget assignments)	8	soluble	No	y1682	22125577	ompX	outer membrane protein X [Yersinia pesti...	176	virulence/pathogenesis / putative cell surface adhesin in various Gram-negative pathogens	Community Requests	1ORM	59.1%	Yersinia pestis

IDP01854 (show subtarget assignments)	1	expressed	No	STM1246	16764600	pagC	virulence membrane protein PAGC precurso...	185	Conserved; Drug target functions	Phase 3: June 2008	1ORM	34.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP00676 (show subtarget assignments)	1	expressed	No	SACOL1492	57284593	nth	endonuclease III	219	Drug Target Function	Phase 2: March 2008	1ORN	62.1%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP04214 (show subtarget assignments)	1	expressed	No	STM1473_1_377	16764819	ompN	outer membrane protein N precursor [Salm...	377	Salmonella essential protein	Phase 4: April 2009	1OSM	66%	Salmonella enterica

IDP04050 (show subtarget assignments)	1	purified	No	YPO1765	218928887	hpaF	5-carboxymethyl-2-hydroxymuconate delta-...	132	conserved gene; putative drug target function;	Phase 4: April 2009	1OTG	67.4%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP91356 (show subtarget assignments)	8	cloned	No	VV1_2923	27366200		DNA-binding protein H-NS [Vibrio vulnifi...	135	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1OV9	31.1%	Vibrio vulnificus

IDP01001 (show subtarget assignments)	1	soluble	No	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP04003 (show subtarget assignments)	1	cloned	No	BAS0126	49183160		50S ribosomal protein L18 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1OVY	75.8%	Bacillus anthracis

IDP02667 (show subtarget assignments)	1	cloned	No	lmo0565	16802608	hisH	imidazole glycerol phosphate synthase su...	208	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1OX4	33.5%	Listeria monocytogenes	Amino acid biosynthesis	Histidine family

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00025 (show subtarget assignments)	1	purified	No	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01370 (show subtarget assignments)	1	purified	No	VC0247	15640277		lipopolysaccharide/O-antigen transport p...	271	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	25.8%	Vibrio cholerae	Transport and binding proteins	Other

IDP01146 (show subtarget assignments)	1	cloned	No	BA_0235	30253735		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	26.8%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02089 (show subtarget assignments)	1	cloned	No	CBU_0424	29541033	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Conserved; Drug target functions	Phase 3: June 2008	1OY0	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00578 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3553	16123697	elbB	isoprenoid biosynthesis protein with ami...	217	Drug Target Function	Phase 2: March 2008	1OY1	63.6%	Yersinia pestis	Unknown function	General

IDP02106 (show subtarget assignments)	1	cloned	No	FTT0654	56707776	elbB	isoprenoid biosynthesis protein [Francis...	219	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OY1	47.5%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP91744 (show subtarget assignments)	8	selected	No	Q76ZW2_VACCW	0			190	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1OYI	39.5%	Vaccinia virus

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP01792 (show subtarget assignments)	1	expressed	No	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02699 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1120c	56708198	tgt	queuine tRNA-ribosyltransferase. [Franci...	367	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OZM	56.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04142 (show subtarget assignments)	1	purified	No	YPO3191	218930221	tgt	queuine tRNA-ribosyltransferase [Yersini...	374	drug target; putative drug target function;	Phase 4: April 2009	1OZM	55.1%	Yersinia pestis	Protein synthesis	tRNA and rRNA base modification

IDP91043 (show subtarget assignments)	8	in_crystallization_trials	No	EFE0003	33355848	vanRG	response regulator [Enterococcus faecali...	235	drug resistance / Component of regulatory system of transcription of vancomycin resistance genes	Community Requests	1P2F	37%	Enterococcus faecalis

IDP91919 (show subtarget assignments)	8	selected	No	SpneCM_010100003360	298254637		choline binding protein G [Streptococcus...	197	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P3C	24.9%	Streptococcus pneumoniae

IDP02437 (show subtarget assignments)	1	expressed	No	FTT1226c	56708288	iscS	cysteine desulfarase [Francisella tulare...	391	Drug Target	Phase 3: June 2008	1P3W	41.9%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Pyruvate familyOther

IDP02019 (show subtarget assignments)	1	cloned	No	CBU_1182	29541752	iscS	cysteine desulfurase [Coxiella burnetii ...	380	Conserved; Drug target functions	Phase 3: June 2008	1P3W	43.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90993 (show subtarget assignments)	8	selected	No	y1334	22125233		cysteine desulfurase [Yersinia pestis KI...	409	other biological interest / enzyme involved in iron-sulfur cluster synthesis	Community Requests	1P3W	87.8%	Yersinia pestis

IDP01735 (show subtarget assignments)	1	soluble	No	CBU_1129	29541703	nifS	cysteine desulfurase [Coxiella burnetii ...	396	Conserved; Drug target functions	Phase 3: June 2008	1P3W	57.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02084 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0639c	15791999	adk	adenylate kinase [Campylobacter jejuni s...	192	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1P4S	34.9%	Campylobacter jejuni	Energy metabolism	Electron transport

IDP91817 (show subtarget assignments)	8	cloned	No	b2217	1788546	rcsB	DNA-binding response regulator in two-co...	216	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1P4W	36.6%	Escherichia coli

IDP00827 (show subtarget assignments)	1	expressed	No	SACOL2507	57285192	sarU	staphylococcal accessory regulator U	247	Conserved Gene / Pathway	Phase 2: March 2008	1P4X	37.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00253 (show subtarget assignments)	1	in_crystallization_trials	No	YFVgp1	9627245		Yellow fever virus Envelope protein	399	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1P58	43.8%	Yellow fever

IDP04028 (show subtarget assignments)	1	purified	No	BAS0109	49183143		30S ribosomal protein S10 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1P6G	61.8%	Bacillus anthracis

IDP04663 (show subtarget assignments)	1	cloned	No	BAS5325	49188309		30S ribosomal protein S18 [Bacillus anth...	77	Proposed to be essential proteins	Phase 4: April 2009	1P6G	50.6%	Bacillus anthracis

IDP00336 (show subtarget assignments)	1	cloned	No	FTT1186	56708252	smpB	SsrA-binding protein	157	Drug Target Function	Phase 2: March 2008	1P6V	48.4%	Francisella tularensis	Protein synthesis	Other

IDP00321 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1105	15792430	smpB	SsrA-binding protein	150	Drug Target Function	Phase 2: March 2008	1P6V	47.3%	Campylobacter jejuni	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP05464 (show subtarget assignments)	1	expressed	No	BA_1489	30255419		superoxide dismutase [Bacillus anthracis...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1P7G	35.5%	Bacillus anthracis	Cellular processes: Detoxification

IDP04592 (show subtarget assignments)	1	expressed	No	BAS0143	49183177		50S ribosomal protein L13 [Bacillus anth...	145	Proposed to be essential proteins	Phase 4: April 2009	1P85	56.6%	Bacillus anthracis

IDP90569 (show subtarget assignments)	8	soluble	No	VC0369	15640396	rplI	50S ribosomal protein L9 [Vibrio cholera...	149	Predicted Essential	Community Requests	1P85	76.5%	Vibrio cholerae

IDP90590 (show subtarget assignments)	8	cloned	No	Cj0770c	15792108		lipoprotein, NLPA family [Campylobacter ...	258	Predicted Essential	Community Requests	1P99	35.7%	Campylobacter jejuni

IDP91970 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100005433	298255040		lipoprotein [Streptococcus pneumoniae st...	284	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P99	35.6%	Streptococcus pneumoniae

IDP92106 (show subtarget assignments)	8	selected	No	TGME49_079450	237845375		adenylosuccinate synthetase, putative [T...	460	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1P9B	48.7%	Toxoplasma gondii

IDP90606 (show subtarget assignments)	8	in_crystallization_trials	No	VC0563	15640585	trmD	tRNA (guanine-N(1)-)-methyltransferase [...	247	Predicted Essential	Community Requests	1P9P	78.1%	Vibrio cholerae

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP02268 (show subtarget assignments)	1	expressed	No	FTT1133	56708209	pilB	Type IV pili nucleotide binding protein,...	592	Conserved; Drug target functions	Phase 3: June 2008	1P9R	31.1%	Francisella tularensis	Cell envelope	Surface structures

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00155 (show subtarget assignments)	1	in_crystallization_trials	No	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP00746 (show subtarget assignments)	1	purified	No	SACOL1717	57284728	hemC	porphobilinogen deaminase	308	Drug Target Function	Phase 2: March 2008	1PDA	45.1%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05217 (show subtarget assignments)	1	in_crystallization_trials	No	CD3421	126701044	hemC	porphobilinogen deaminase [Clostridium d...	301	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PDA	37.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90990 (show subtarget assignments)	8	selected	No	y1223	22125125	nrdE	ribonucleotide-diphosphate reductase sub...	716	iron-regulated reductase	Community Requests	1PEM	72.6%	Yersinia pestis

IDP91811 (show subtarget assignments)	8	soluble	No	b3916	1790350	pfkA	6-phosphofructokinase I [Escherichia col...	320	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1PFK	100%	Escherichia coli

IDP01409 (show subtarget assignments)	1	purified	No	VC0972	15640988		porin, putative	349	Conserved Gene / Pathway	Phase 2: March 2008	1PHO	20.9%	Vibrio cholerae	Transport and binding proteins	Porins

IDP04468 (show subtarget assignments)	1	cloned	No	YPO2205	115347912	trpC	tryptophan biosynthesis protein TrpCF [Y...	475	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PII	69.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP01871 (show subtarget assignments)	1	cloned	No	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP91445 (show subtarget assignments)	8	cloned	No	VV1_0414	27363882		D-amino acid dehydrogenase small subunit...	417	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1PJ5	18.5%	Vibrio vulnificus

IDP04146 (show subtarget assignments)	1	expressed	No	YPO2147	218929248	dadA	D-amino acid dehydrogenase small subunit...	434	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PJ5	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP91305 (show subtarget assignments)	8	soluble	No	STM3477	16766765	cysG	siroheme synthase	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	99.8%	Salmonella enterica

IDP91250 (show subtarget assignments)	8	expressed	No	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00534 (show subtarget assignments)	1	purified	No	YPO3367	16123517	cysG	siroheme synthase	472	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	52.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00533 (show subtarget assignments)	1	purified	No	YPO0158	16120501	cysG	siroheme synthase	470	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	70.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91222 (show subtarget assignments)	8	soluble	No	SF3387	24114633	cysG	siroheme synthase [Shigella flexneri 2a ...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Shigella flexneri

IDP91293 (show subtarget assignments)	8	soluble	No	SPA3343	56415395	cysG	siroheme synthase [Salmonella enterica s...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	99.6%	Salmonella enterica

IDP91260 (show subtarget assignments)	8	soluble	No	NT02SA2397	14248172	nasF	uroporphyrin-III C-methyl transferase [S...	325	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	28%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01415 (show subtarget assignments)	1	in_crystallization_trials	No	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91226 (show subtarget assignments)	8	soluble	No	NT04EC4239	26110396	cysG	Siroheme synthase [Escherichia coli CFT0...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00010 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05308 (show subtarget assignments)	1	soluble	No	CD3420	126701043	hemD	porphyrin biosynthesis protein [Clostrid...	499	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PJQ	25.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04084 (show subtarget assignments)	1	cloned	No	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00008 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1445	30255378	cysG	uroporphyrin-III C-methyltransferase	258	Drug Target Homolog	Phase 1: October 2007	1PJQ	43.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05220 (show subtarget assignments)	1	cloned	No	Cj1101	6968529	-	putative integral membrane protein [Camp...	670	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	36.6%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05118 (show subtarget assignments)	1	cloned	No	Z5902	12519310		putative helicase [Escherichia coli O157...	704	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	12.8%	Escherichia coli	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05759 (show subtarget assignments)	1	cloned	No	lmo1759	16803799	pcrA	ATP-dependent DNA helicase [Listeria mon...	733	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	65.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP04064 (show subtarget assignments)	1	expressed	No	BAS0127	49183161		30S ribosomal protein S5 [Bacillus anthr...	166	Proposed to be essential proteins	Phase 4: April 2009	1PKP	75.3%	Bacillus anthracis

IDP91824 (show subtarget assignments)	8	cloned	No	b1676	1787965	pykF	pyruvate kinase I [Escherichia coli str....	470	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1PKY	99.8%	Escherichia coli

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP05035 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1300	30255245	potD	spermidine/putrescine ABC transporter, s...	345	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1POT	35.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01418 (show subtarget assignments)	1	purified	No	VC1424	15641435		spermidine/putrescine ABC transporter, p...	345	Conserved Gene / Pathway	Phase 2: March 2008	1POT	61.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01419 (show subtarget assignments)	1	in_crystallization_trials	No	VC1425	15641436		spermidine/putrescine ABC transporter, p...	366	Conserved Gene / Pathway	Phase 2: March 2008	1POT	52.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91673 (show subtarget assignments)	8	selected	No	CD44_HUMAN	0			742	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1POZ	21.4%	Homo sapiens

IDP90634 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3403	16123552	panD	aspartate alpha-decarboxylase [Yersinia ...	126	Predicted Essential	Community Requests	1PPY	78.6%	Yersinia pestis

IDP92083 (show subtarget assignments)	8	selected	No	TGME49_109210	237829785		peroxidoxin 2 [Toxoplasma gondii ME49]	224	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1PRX	54%	Toxoplasma gondii

IDP01051 (show subtarget assignments)	1	expressed	No	STM3219	16766518	fadH	2,4-dieonyl-CoA reductase	672	Drug Target Function	Phase 2: March 2008	1PS9	85.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP00551 (show subtarget assignments)	1	soluble	No	YPO0589	16120918	fadH	2,4-dienoyl-CoA reductase	673	Virulence Associated Factor	Phase 2: March 2008	1PS9	72.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP01438 (show subtarget assignments)	1	expressed	No	VC1993	15641995		2,4-dienoyl-CoA reductase	666	Drug Target Function	Phase 2: March 2008	1PS9	56.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP00078 (show subtarget assignments)	0	work_stopped	No	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01492
(show subtarget assignments)

1

purified

No

VCA0702

15601458

iron-containing alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1OJ7

50.8%

Vibrio cholerae

Energy metabolism

Fermentation

IDP00419
(show subtarget assignments)

1

purified

No

YPO0678

16121001

putative iron-containing alcohol dehydro...

385

Drug Target Function

Phase 2: March 2008

1OJ7

76.7%

Yersinia pestis

Central intermediary metabolism

Other

IDP00031
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1078

30254808

blaI

penicillinase repressor

132

Virulence

Phase 1: October 2007

1OKR

35.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01993
(show subtarget assignments)

1

cloned

No

lmo1476

16803516

hemN

coproporphyrinogen III oxidase [Listeria...

385

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

27.4%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05210
(show subtarget assignments)

1

cloned

No

CD2464

126700081

hemN

oxygen-independent coproporphyrinogen II...

380

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1OLT

20.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02195
(show subtarget assignments)

1

expressed

No

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02138
(show subtarget assignments)

1

expressed

No

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02134
(show subtarget assignments)

1

soluble

No

CBU_0597

29541198

oxygen-independent coproporphyrinogen II...

375

Conserved; Drug target functions

Phase 3: June 2008

1OLT

20.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01088
(show subtarget assignments)

1

expressed

No

STM4512

16767756

iadA

isoaspartyl dipeptidase

390

Drug Target Function

Phase 2: March 2008

1ONX

81%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP91281
(show subtarget assignments)

8

expressed

No

NT05BA5437

49182125

RNA polymerase sigma-70 factor, ECF subf...

175

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1OR7

22.5%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP90290
(show subtarget assignments)

8

purified

No

TGME49_019520

211968370

arginine N-methyltransferase 1 [Toxoplas...

392

The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...

Community Requests

1OR8

44.9%

Toxoplasma gondii

IDP90528
(show subtarget assignments)

8

cloned

No

VCA1063

15601814

ornithine decarboxylase [Vibrio cholerae...

720

Predicted Essential

Community Requests

1ORD

59.1%

Vibrio cholerae

IDP01045
(show subtarget assignments)

1

soluble

No

STM3114

16766415

speC

ornithine decarboxylase isozyme

711

Conserved Gene / Pathway

Phase 2: March 2008

1ORD

53.8%

Salmonella enterica

Central intermediary metabolism

Polyamine biosynthesis

IDP90997
(show subtarget assignments)

8

soluble

No

y1682

22125577

ompX

outer membrane protein X [Yersinia pesti...

176

virulence/pathogenesis / putative cell surface adhesin in various Gram-negative pathogens

Community Requests

1ORM

59.1%

Yersinia pestis

IDP01854
(show subtarget assignments)

1

expressed

No

STM1246

16764600

pagC

virulence membrane protein PAGC precurso...

185

Conserved; Drug target functions

Phase 3: June 2008

1ORM

34.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP00676
(show subtarget assignments)

1

expressed

No

SACOL1492

57284593

nth

endonuclease III

219

Drug Target Function

Phase 2: March 2008

1ORN

62.1%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP04214
(show subtarget assignments)

1

expressed

No

STM1473_1_377

16764819

ompN

outer membrane protein N precursor [Salm...

377

Salmonella essential protein

Phase 4: April 2009

1OSM

66%

Salmonella enterica

IDP04050
(show subtarget assignments)

1

purified

No

YPO1765

218928887

hpaF

5-carboxymethyl-2-hydroxymuconate delta-...

132

conserved gene; putative drug target function;

Phase 4: April 2009

1OTG

67.4%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP91356
(show subtarget assignments)

8

cloned

No

VV1_2923

27366200

DNA-binding protein H-NS [Vibrio vulnifi...

135

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1OV9

31.1%

Vibrio vulnificus

IDP01001
(show subtarget assignments)

1

soluble

No

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP04003
(show subtarget assignments)

1

cloned

No

BAS0126

49183160

50S ribosomal protein L18 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1OVY

75.8%

Bacillus anthracis

IDP02667
(show subtarget assignments)

1

cloned

No

lmo0565

16802608

hisH

imidazole glycerol phosphate synthase su...

208

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1OX4

33.5%

Listeria monocytogenes

Amino acid biosynthesis

Histidine family

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00025
(show subtarget assignments)

1

purified

No

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01370
(show subtarget assignments)

1

purified

No

VC0247

15640277

lipopolysaccharide/O-antigen transport p...

271

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

25.8%

Vibrio cholerae

Transport and binding proteins

Other

IDP01146
(show subtarget assignments)

1

cloned

No

BA_0235

30253735

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

26.8%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02089
(show subtarget assignments)

1

cloned

No

CBU_0424

29541033

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Conserved; Drug target functions

Phase 3: June 2008

1OY0

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00578
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3553

16123697

elbB

isoprenoid biosynthesis protein with ami...

217

Drug Target Function

Phase 2: March 2008

1OY1

63.6%

Yersinia pestis

Unknown function

General

IDP02106
(show subtarget assignments)

1

cloned

No

FTT0654

56707776

elbB

isoprenoid biosynthesis protein [Francis...

219

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OY1

47.5%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP91744
(show subtarget assignments)

8

selected

No

Q76ZW2_VACCW

0

190

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1OYI

39.5%

Vaccinia virus

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP01792
(show subtarget assignments)

1

expressed

No

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02699
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1120c

56708198

tgt

queuine tRNA-ribosyltransferase. [Franci...

367

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OZM

56.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04142
(show subtarget assignments)

1

purified

No

YPO3191

218930221

tgt

queuine tRNA-ribosyltransferase [Yersini...

374

drug target; putative drug target function;

Phase 4: April 2009

1OZM

55.1%

Yersinia pestis

Protein synthesis

tRNA and rRNA base modification

IDP91043
(show subtarget assignments)

8

in_crystallization_trials

No

EFE0003

33355848

vanRG

response regulator [Enterococcus faecali...

235

drug resistance / Component of regulatory system of transcription of vancomycin resistance genes

Community Requests

1P2F

37%

Enterococcus faecalis

IDP91919
(show subtarget assignments)

8

selected

No

SpneCM_010100003360

298254637

choline binding protein G [Streptococcus...

197

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P3C

24.9%

Streptococcus pneumoniae

IDP02437
(show subtarget assignments)

1

expressed

No

FTT1226c

56708288

iscS

cysteine desulfarase [Francisella tulare...

391

Drug Target

Phase 3: June 2008

1P3W

41.9%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Pyruvate familyOther

IDP02019
(show subtarget assignments)

1

cloned

No

CBU_1182

29541752

iscS

cysteine desulfurase [Coxiella burnetii ...

380

Conserved; Drug target functions

Phase 3: June 2008

1P3W

43.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90993
(show subtarget assignments)

8

selected

No

y1334

22125233

cysteine desulfurase [Yersinia pestis KI...

409

other biological interest / enzyme involved in iron-sulfur cluster synthesis

Community Requests

1P3W

87.8%

Yersinia pestis

IDP01735
(show subtarget assignments)

1

soluble

No

CBU_1129

29541703

nifS

cysteine desulfurase [Coxiella burnetii ...

396

Conserved; Drug target functions

Phase 3: June 2008

1P3W

57.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02084
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0639c

15791999

adk

adenylate kinase [Campylobacter jejuni s...

192

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1P4S

34.9%

Campylobacter jejuni

Energy metabolism

Electron transport

IDP91817
(show subtarget assignments)

8

cloned

No

b2217

1788546

rcsB

DNA-binding response regulator in two-co...

216

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1P4W

36.6%

Escherichia coli

IDP00827
(show subtarget assignments)

1

expressed

No

SACOL2507

57285192

sarU

staphylococcal accessory regulator U

247

Conserved Gene / Pathway

Phase 2: March 2008

1P4X

37.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00253
(show subtarget assignments)

1

in_crystallization_trials

No

YFVgp1

9627245

Yellow fever virus Envelope protein

399

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1P58

43.8%

Yellow fever

IDP04028
(show subtarget assignments)

1

purified

No

BAS0109

49183143

30S ribosomal protein S10 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1P6G

61.8%

Bacillus anthracis

IDP04663
(show subtarget assignments)

1

cloned

No

BAS5325

49188309

30S ribosomal protein S18 [Bacillus anth...

77

Proposed to be essential proteins

Phase 4: April 2009

1P6G

50.6%

Bacillus anthracis

IDP00336
(show subtarget assignments)

1

cloned

No

FTT1186

56708252

smpB

SsrA-binding protein

157

Drug Target Function

Phase 2: March 2008

1P6V

48.4%

Francisella tularensis

Protein synthesis

Other

IDP00321
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1105

15792430

smpB

SsrA-binding protein

150

Drug Target Function

Phase 2: March 2008

1P6V

47.3%

Campylobacter jejuni

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP05464
(show subtarget assignments)

1

expressed

No

BA_1489

30255419

superoxide dismutase [Bacillus anthracis...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1P7G

35.5%

Bacillus anthracis

Cellular processes: Detoxification

IDP04592
(show subtarget assignments)

1

expressed

No

BAS0143

49183177

50S ribosomal protein L13 [Bacillus anth...

145

Proposed to be essential proteins

Phase 4: April 2009

1P85

56.6%

Bacillus anthracis

IDP90569
(show subtarget assignments)

8

soluble

No

VC0369

15640396

rplI

50S ribosomal protein L9 [Vibrio cholera...

149

Predicted Essential

Community Requests

1P85

76.5%

Vibrio cholerae

IDP90590
(show subtarget assignments)

8

cloned

No

Cj0770c

15792108

lipoprotein, NLPA family [Campylobacter ...

258

Predicted Essential

Community Requests

1P99

35.7%

Campylobacter jejuni

IDP91970
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100005433

298255040

lipoprotein [Streptococcus pneumoniae st...

284

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P99

35.6%

Streptococcus pneumoniae

IDP92106
(show subtarget assignments)

8

selected

No

TGME49_079450

237845375

adenylosuccinate synthetase, putative [T...

460

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1P9B

48.7%

Toxoplasma gondii

IDP90606
(show subtarget assignments)

8

in_crystallization_trials

No

VC0563

15640585

trmD

tRNA (guanine-N(1)-)-methyltransferase [...

247

Predicted Essential

Community Requests

1P9P

78.1%

Vibrio cholerae

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures

IDP02268
(show subtarget assignments)

1

expressed

No

FTT1133

56708209

pilB

Type IV pili nucleotide binding protein,...

592

Conserved; Drug target functions

Phase 3: June 2008

1P9R

31.1%

Francisella tularensis

Cell envelope

Surface structures

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00155
(show subtarget assignments)

1

in_crystallization_trials

No

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP00746
(show subtarget assignments)

1

purified

No

SACOL1717

57284728

hemC

porphobilinogen deaminase

308

Drug Target Function

Phase 2: March 2008

1PDA

45.1%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05217
(show subtarget assignments)

1

in_crystallization_trials

No

CD3421

126701044

hemC

porphobilinogen deaminase [Clostridium d...

301

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PDA

37.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90990
(show subtarget assignments)

8

selected

No

y1223

22125125

nrdE

ribonucleotide-diphosphate reductase sub...

716

iron-regulated reductase

Community Requests

1PEM

72.6%

Yersinia pestis

IDP91811
(show subtarget assignments)

8

soluble

No

b3916

1790350

pfkA

6-phosphofructokinase I [Escherichia col...

320

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1PFK

100%

Escherichia coli

IDP01409
(show subtarget assignments)

1

purified

No

VC0972

15640988

porin, putative

349

Conserved Gene / Pathway

Phase 2: March 2008

1PHO

20.9%

Vibrio cholerae

Transport and binding proteins

Porins

IDP04468
(show subtarget assignments)

1

cloned

No

YPO2205

115347912

trpC

tryptophan biosynthesis protein TrpCF [Y...

475

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PII

69.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP01871
(show subtarget assignments)

1

cloned

No

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP91445
(show subtarget assignments)

8

cloned

No

VV1_0414

27363882

D-amino acid dehydrogenase small subunit...

417

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1PJ5

18.5%

Vibrio vulnificus

IDP04146
(show subtarget assignments)

1

expressed

No

YPO2147

218929248

dadA

D-amino acid dehydrogenase small subunit...

434

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PJ5

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP91305
(show subtarget assignments)

8

soluble

No

STM3477

16766765

cysG

siroheme synthase

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

99.8%

Salmonella enterica

IDP91250
(show subtarget assignments)

8

expressed

No

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00534
(show subtarget assignments)

1

purified

No

YPO3367

16123517

cysG

siroheme synthase

472

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

52.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00533
(show subtarget assignments)

1

purified

No

YPO0158

16120501

cysG

siroheme synthase

470

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

70.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91222
(show subtarget assignments)

8

soluble

No

SF3387

24114633

cysG

siroheme synthase [Shigella flexneri 2a ...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Shigella flexneri

IDP91293
(show subtarget assignments)

8

soluble

No

SPA3343

56415395

cysG

siroheme synthase [Salmonella enterica s...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

99.6%

Salmonella enterica

IDP91260
(show subtarget assignments)

8

soluble

No

NT02SA2397

14248172

nasF

uroporphyrin-III C-methyl transferase [S...

325

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

28%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01415
(show subtarget assignments)

1

in_crystallization_trials

No

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91226
(show subtarget assignments)

8

soluble

No

NT04EC4239

26110396

cysG

Siroheme synthase [Escherichia coli CFT0...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00010
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05308
(show subtarget assignments)

1

soluble

No

CD3420

126701043

hemD

porphyrin biosynthesis protein [Clostrid...

499

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PJQ

25.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04084
(show subtarget assignments)

1

cloned

No

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00008
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1445

30255378

cysG

uroporphyrin-III C-methyltransferase

258

Drug Target Homolog

Phase 1: October 2007

1PJQ

43.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05220
(show subtarget assignments)

1

cloned

No

Cj1101

6968529

-

putative integral membrane protein [Camp...

670

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

36.6%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05118
(show subtarget assignments)

1

cloned

No

Z5902

12519310

putative helicase [Escherichia coli O157...

704

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

12.8%

Escherichia coli

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05759
(show subtarget assignments)

1

cloned

No

lmo1759

16803799

pcrA

ATP-dependent DNA helicase [Listeria mon...

733

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

65.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP04064
(show subtarget assignments)

1

expressed

No

BAS0127

49183161

30S ribosomal protein S5 [Bacillus anthr...

166

Proposed to be essential proteins

Phase 4: April 2009

1PKP

75.3%

Bacillus anthracis

IDP91824
(show subtarget assignments)

8

cloned

No

b1676

1787965

pykF

pyruvate kinase I [Escherichia coli str....

470

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1PKY

99.8%

Escherichia coli

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP05035
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1300

30255245

potD

spermidine/putrescine ABC transporter, s...

345

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1POT

35.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01418
(show subtarget assignments)

1

purified

No

VC1424

15641435

spermidine/putrescine ABC transporter, p...

345

Conserved Gene / Pathway

Phase 2: March 2008

1POT

61.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01419
(show subtarget assignments)

1

in_crystallization_trials

No

VC1425

15641436

spermidine/putrescine ABC transporter, p...

366

Conserved Gene / Pathway

Phase 2: March 2008

1POT

52.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91673
(show subtarget assignments)

8

selected

No

CD44_HUMAN

0

742

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1POZ

21.4%

Homo sapiens

IDP90634
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3403

16123552

panD

aspartate alpha-decarboxylase [Yersinia ...

126

Predicted Essential

Community Requests

1PPY

78.6%

Yersinia pestis

IDP92083
(show subtarget assignments)

8

selected

No

TGME49_109210

237829785

peroxidoxin 2 [Toxoplasma gondii ME49]

224

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1PRX

54%

Toxoplasma gondii

IDP01051
(show subtarget assignments)

1

expressed

No

STM3219

16766518

fadH

2,4-dieonyl-CoA reductase

672

Drug Target Function

Phase 2: March 2008

1PS9

85.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP00551
(show subtarget assignments)

1

soluble

No

YPO0589

16120918

fadH

2,4-dienoyl-CoA reductase

673

Virulence Associated Factor

Phase 2: March 2008

1PS9

72.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP01438
(show subtarget assignments)

1

expressed

No

VC1993

15641995

2,4-dienoyl-CoA reductase

666

Drug Target Function

Phase 2: March 2008

1PS9

56.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP00078
(show subtarget assignments)

0

work_stopped

No

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides