Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91645 (show subtarget assignments)	8	soluble	No	NP_215862	15608486		acyl-CoA dehydrogenase [Mycobacterium tu...	386	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1WS9	27.2%	Mycobacterium tuberculosis

IDP90751 (show subtarget assignments)	8	cloned	No	Cj1291c	15792614	accB	acetyl-CoA carboxylase biotin carboxyl c...	151	Predicted Essential	Community Requests	1A6X	27.2%	Campylobacter jejuni

IDP90641 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0099	15791487	birA	biotin--protein ligase [Campylobacter je...	217	Predicted Essential	Community Requests	2EAY	27.2%	Campylobacter jejuni

IDP00738 (show subtarget assignments)	1	cloned	No	SACOL0994	57284368	oppF	oligopeptide ABC transporter, ATP-bindin...	313	Drug Target Function	Phase 2: March 2008	2YZ2	27.2%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01379 (show subtarget assignments)	1	purified	No	VC0474	15640501		iron-regulated virulence regulatory prot...	298	Conserved Gene / Pathway	Phase 2: March 2008	3SZP	27.2%	Vibrio cholerae	Regulatory functions	Other

IDP90674 (show subtarget assignments)	8	cloned	No	Cj0542	15791903	hemA	glutamyl-tRNA reductase [Campylobacter j...	432	Predicted Essential	Community Requests	1GPJ	27.3%	Campylobacter jejuni

IDP02657 (show subtarget assignments)	1	cloned	No	lmo0203	16802249	mpl	Zinc metalloproteinase precursor [Lister...	510	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...	Phase 3: June 2008	1BQB	27.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02777 (show subtarget assignments)	1	soluble	No	GBAA4698	47529997	hemA	glutamyl-tRNA reductase [Bacillus anthra...	444	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	27.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02714 (show subtarget assignments)	1	purified	No	FTT1231	56708293	mesJ	PP-loop family protein [Francisella tula...	398	Conserved; Drug target functions	Phase 3: June 2008	1NI5	27.3%	Francisella tularensis	Cellular processes	Cell division

IDP01667 (show subtarget assignments)	1	expressed	No	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	Phase 3: June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01391 (show subtarget assignments)	1	cloned	No	VC0633	15640653		outer membrane protein OmpU	350	Conserved Gene / Pathway	Phase 2: March 2008	3HW9	27.3%	Vibrio cholerae	Cell envelope	Other

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05027 (show subtarget assignments)	1	purified	No	BA_0231	30253731		putative oligopeptide ABC transporter, o...	555	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	27.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01395 (show subtarget assignments)	1	purified	No	VC0704	15640723		spermidine/putrescine ABC transporter, p...	359	Conserved Gene / Pathway	Phase 2: March 2008	3TTK	27.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91965 (show subtarget assignments)	8	cloned	No	SpneCM_010100004182	298254799		pneumococcal surface protein, putative [...	292	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2WW5	27.4%	Streptococcus pneumoniae

IDP02252 (show subtarget assignments)	1	soluble	No	YPO1229	16121516	tsr2	putative methyl-accepting chemotaxis pro...	595	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	27.4%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02778 (show subtarget assignments)	1	cloned	No	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP05037 (show subtarget assignments)	1	soluble	No	BA_1836	30256106		putative polysaccharide deacetylase [Bac...	234	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C71	27.4%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02655 (show subtarget assignments)	1	cloned	No	GBAA3977	47529267	sipS-2	signal peptidase I S [Bacillus anthracis...	183	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1B12	27.4%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01993 (show subtarget assignments)	1	cloned	No	lmo1476	16803516	hemN	coproporphyrinogen III oxidase [Listeria...	385	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	27.4%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05191 (show subtarget assignments)	1	purified	No	CD0265	126697837	fleN	flagellar number regulator [Clostridium ...	292	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1HYQ	27.4%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04306 (show subtarget assignments)	8	selected	No	CAC05809	12329078	ipgE	IpgE, cytoplasmic chaperone for IpgD [Sh...	120	Shigella effector protein	Community Requests	1K3S	27.5%	Shigella flexneri

IDP90772 (show subtarget assignments)	8	soluble	No	Cj0316	15791684	pheA	chorismate mutase/prephenate dehydratase...	357	Predicted Essential	Community Requests	3MWB	27.5%	Campylobacter jejuni

IDP00529 (show subtarget assignments)	1	expressed	No	YPO2734	16122938	ccmA	putative heme exporter protein A	218	Virulence Associated Factor	Phase 2: March 2008	1B0U	27.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP91338 (show subtarget assignments)	8	expressed	No	VV2_0132	27366588		cytochrome c553 [Vibrio vulnificus CMCP6...	207	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1FCD	27.5%	Vibrio vulnificus

IDP02396 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3604	47528890	argH-1	argininosuccinate lyase [Bacillus anthra...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E9F	27.5%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP00777 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0665	57284261		iron compound ABC transporter, iron comp...	295	Conserved Gene / Pathway	Phase 2: March 2008	3EIW	27.5%	Staphylococcus aureus	Cell envelope	Other

IDP00730 (show subtarget assignments)	1	soluble	No	SACOL2453	57286449		amino acid ABC transporter, ATP-binding ...	408	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	27.5%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP92045 (show subtarget assignments)	8	selected	No	TGME49_042730	237834991		guanylate kinase, putative [Toxoplasma g...	346	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1LVG	27.5%	Toxoplasma gondii

IDP05283 (show subtarget assignments)	1	soluble	No	CD0229	126697800	flgM	negative regulator of flagellin synthesi...	91	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	27.5%	Clostridium difficile	Regulatory functions: DNA interactions

IDP90636 (show subtarget assignments)	8	purified	No	Cj0432c	15791799	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	402	Predicted Essential	Community Requests	1E0D	27.6%	Campylobacter jejuni

IDP91298 (show subtarget assignments)	8	cloned	No	STM1269	16764620	-	chorismate mutase	181	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2GBB	27.6%	Salmonella enterica

IDP01062 (show subtarget assignments)	1	cloned	No	STM3626	16766913	dppF	dipeptide transporter ATP-binding subuni...	337	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.6%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP91802 (show subtarget assignments)	8	crystallized	No	lpg0123	52840378	dsbA	thiol:disulfide interchange protein DsbA...	217	virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...	Community Requests	3L9S	27.6%	Legionella pneumophila

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02088 (show subtarget assignments)	1	cloned	No	Cj1338c	15792661	flaB	flagellin [Campylobacter jejuni subsp. j...	572	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	27.6%	Campylobacter jejuni	Cell envelope	Surface structures

IDP05143 (show subtarget assignments)	1	cloned	No	BAS4423	49187418	-	triple helix repeat-containing collagen ...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WCK	27.6%	Bacillus anthracis	Unknown function: General

IDP91789 (show subtarget assignments)	8	purified	No	TETS_LISMO	6094462		RecName: Full=Tetracycline resistance pr...	641	drug resistance / Tetracycline resistance	Community Requests	1DAR	27.6%	Listeria monocytogenes

IDP05552 (show subtarget assignments)	1	soluble	No	lmo0849	16802890	-	amidase [Listeria monocytogenes EGD-e]	616	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	27.6%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP00636 (show subtarget assignments)	1	cloned	No	SACOL1118	57285904	typA	GTP-binding protein TypA	615	Drug Target Function	Phase 2: March 2008	3E3X	27.6%	Staphylococcus aureus	Unknown function	General

IDP01893 (show subtarget assignments)	1	expressed	No	PSLT017	17233482	pefC	usher protein [Salmonella typhimurium LT...	802	Conserved; Drug target functions	Phase 3: June 2008	3RFZ	27.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP04081 (show subtarget assignments)	1	purified	No	BAS0361	49183389		DNA topoisomerase III [Bacillus anthraci...	729	Proposed to be essential proteins	Phase 4: April 2009	1D6M	27.7%	Bacillus anthracis

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02615 (show subtarget assignments)	1	expressed	No	GBAA4677	47529976		ribonuclease [Bacillus anthracis str. 'A...	458	Conserved; Drug target functions	Phase 3: June 2008	2BX2	27.7%	Bacillus anthracis	Cellular processes	Cell division

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04679 (show subtarget assignments)	1	expressed	No	GBAA2644	47527936	kinB-2	sporulation kinase B [Bacillus anthracis...	422	putative drug target function;	Phase 4: April 2009	3D36	27.7%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04455 (show subtarget assignments)	1	expressed	No	YPO1336	115347097		putative RNA methyltransferase [Yersinia...	376	conserved gene; putative drug target function;	Phase 4: April 2009	2JJQ	27.7%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP02121 (show subtarget assignments)	1	cloned	No	FTT0360	56707511		Short-chain dehydrogenase/reductase [Fra...	274	Drug Target	Phase 3: June 2008	1FDW	27.7%	Francisella tularensis	Central intermediary metabolism	Other

IDP05605 (show subtarget assignments)	1	cloned	No	BA_4978	30259470		collagen triple helix repeat domain prot...	469	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	27.7%	Bacillus anthracis	Unknown function: General

IDP02034 (show subtarget assignments)	1	cloned	No	lmo0059	16802107		hypothetical protein lmo0059 [Listeria m...	83	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008	2BPS	27.7%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02489 (show subtarget assignments)	1	selected	No	GBAA3099	47528392	sipU	Signal peptidase I U [Bacillus anthracis...	183	Drug target motif; Drug target functions	Phase 3: June 2008	1T7D	27.8%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP00806 (show subtarget assignments)	1	cloned	No	SACOL1861	57284782	hsdS	type I restriction-modification enzyme, ...	399	Drug Target Function	Phase 2: March 2008	1YF2	27.8%	Staphylococcus aureus	DNA metabolism	Restriction/modification

IDP92016 (show subtarget assignments)	8	selected	No	TGME49_078830	237842577		glucose-6-phosphate dehydrogenase, putat...	878	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BH9	27.8%	Toxoplasma gondii

IDP90144 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_189.5	68449261		bifunctional IL-1-beta-inhibitor/prevent...	126	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	1G0Y	27.8%	Monkeypox virus

IDP90633 (show subtarget assignments)	8	cloned	No	VC1971	15641973		O-succinylbenzoic acid--CoA ligase [Vibr...	476	Predicted Essential	Community Requests	2QVX	27.9%	Vibrio cholerae

IDP01754 (show subtarget assignments)	1	expressed	No	CBU_0803	29541397		efflux transporter, RND family, MFP subu...	351	Conserved; Drug target functions	Phase 3: June 2008	1T5E	27.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP00092 (show subtarget assignments)	1	expressed	No	NT01SF0466	30040219	hemH	ferrochelatase	320	Essential	Phase 1: October 2007	1L8X	27.9%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90548 (show subtarget assignments)	8	cloned	No	Cj0960c	15792289	rnpA	ribonuclease P protein component [Campyl...	108	Predicted Essential	Community Requests	1A6F	27.9%	Campylobacter jejuni

IDP05023 (show subtarget assignments)	1	expressed	No	BAS2353	49185362	-	hemolysin II, C-terminal [Bacillus anthr...	240	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3ANZ	27.9%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP05751 (show subtarget assignments)	1	soluble	No	lmo0219	16802265	-	hypothetical protein lmo0219 [Listeria m...	648	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3A2K	27.9%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides

IDP91781 (show subtarget assignments)	8	purified	No	AAV80411	56155277	tetO	TetO [Enterococcus faecalis]	639	drug resistance / Tetracycline resistance	Community Requests	1DAR	27.9%	Enterococcus faecalis

IDP05651 (show subtarget assignments)	1	soluble	No	Cj1183c	6968610	cfa	guanylate kinase [Campylobacter jejuni s...	387	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1KP9	27.9%	Campylobacter jejuni	Fatty acid and phospholipid metabolism: Biosynthesis

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP90745 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1622	15792927	ribD	putative riboflavin-specific deaminase [...	336	Predicted Essential	Community Requests	2HXV	28%	Campylobacter jejuni

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP02570 (show subtarget assignments)	1	cloned	No	Cj1339c	15792662	flaA	flagellin [Campylobacter jejuni subsp. j...	572	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	28%	Campylobacter jejuni	Cell envelope	Surface structures

IDP01411 (show subtarget assignments)	1	purified	No	VC1095	15641108		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	28%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP05042 (show subtarget assignments)	1	soluble	No	BA_2921	30257513		putative sulfonate ABC transporter, sulf...	328	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X26	28%	Bacillus anthracis	Transport and binding proteins: Anions

IDP05738 (show subtarget assignments)	1	cloned	No	CD2090	126699707		putative xanthine/uracile permease [Clos...	453	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3QE7	28%	Clostridium difficile	Transport and binding proteins: Nucleosides, purines and pyrimidines

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP91260 (show subtarget assignments)	8	soluble	No	NT02SA2397	14248172	nasF	uroporphyrin-III C-methyl transferase [S...	325	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	28%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP01983 (show subtarget assignments)	0	work_stopped	No	Cj1437c	15792755		putative aminotransferase [Campylobacter...	367	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3GET	28.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04290 (show subtarget assignments)	1	cloned	No	YPO3099	218930141	manC	mannose-1-phosphate guanylyltransferase ...	470	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2CU2	28.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides

IDP02463 (show subtarget assignments)	1	expressed	No	YPO1769	16122023	hpaB	4-hydroxyphenylacetate 3-monooxygenase [...	520	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2YYG	28.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP05768 (show subtarget assignments)	1	cloned	No	SACOL0553	57651385		hypothetical protein SACOL0553 [Staphylo...	431	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3A2K	28.1%	Staphylococcus aureus	Protein synthesis: tRNA and rRNA base modification

IDP01365 (show subtarget assignments)	1	purified	No	VC0201	15640231		iron(III) ABC transporter, ATP-binding p...	285	Conserved Gene / Pathway	Phase 2: March 2008	1JJ7	28.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05227 (show subtarget assignments)	1	soluble	No	lmo0541	16802584	-	hypothetical protein lmo0541 [Listeria m...	306	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3EIW	28.1%	Listeria monocytogenes	Transport and binding proteins: Cations and iron carrying compounds

IDP02073 (show subtarget assignments)	1	expressed	No	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP02691 (show subtarget assignments)	1	purified	No	FTT0943c	56708040	folB	dihydroneopterin aldolase [Francisella t...	117	Drug Target	Phase 3: June 2008	1SQL	28.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01933 (show subtarget assignments)	1	soluble	No	FTT0061	56707240	atpH	F0F1 ATP synthase subunit delta [Francis...	174	Conserved; Drug target functions	Phase 3: June 2008	2WSS	28.2%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP91228 (show subtarget assignments)	8	soluble	No	NT04EC3200	26109368	pheA	P-protein [Escherichia coli CFT073]	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	28.2%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91239 (show subtarget assignments)	8	expressed	No	HP0804	2313934		GTP cyclohydrolase II/3,4-dihydroxy-2-bu...	344	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1TKS	28.2%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP92139 (show subtarget assignments)	8	selected	No	TGME49_058030	237831459		DNA polymerase delta catalytic subunit, ...	1268	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3IAY	28.2%	Toxoplasma gondii

IDP01321 (show subtarget assignments)	1	purified	No	VC2082	15642082		zinc ABC transporter, ATP-binding protei...	262	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01153 (show subtarget assignments)	1	cloned	No	BA_5712	30260159		yycI protein	280	Conserved Gene / Pathway	Phase 2: March 2008	2O3O	28.2%	Bacillus anthracis	Cellular processes	Cell division

IDP04288 (show subtarget assignments)	1	expressed	No	YPCD1.08c	5832431	YPCD1.08c	hypothetical protein YPCD1.08c [Yersinia...	99	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	28.3%	Yersinia pestis

IDP01371 (show subtarget assignments)	1	in_crystallization_trials	No	VC0250	15640280		iron-containing alcohol dehydrogenase fa...	374	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	28.3%	Vibrio cholerae	Energy metabolism	Fermentation

IDP02361 (show subtarget assignments)	1	expressed	No	CBU_1550	29542109	ptsP	phosphoenolpyruvate-protein phosphotrans...	759	Conserved; Drug target functions	Phase 3: June 2008	2HRO	28.3%	Coxiella burnetii	Signal transduction	PTS

IDP01081 (show subtarget assignments)	1	soluble	No	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	28.4%	Salmonella enterica	Cellular processes	Detoxification

IDP90084 (show subtarget assignments)	8	soluble	No	ZP_01795673	145640079		hypothetical protein CGSHiII_00674 [Haem...	148	The protein we would like structure analyzed is from Haemophilus influenzae. Pri...	Community Requests	2XM6	28.4%	Haemophilus influenzae

IDP01944 (show subtarget assignments)	1	cloned	No	Cj1427c	15792745		putative sugar-nucleotide epimerase/dehy...	313	Known Predicted virulence-capsule biosynthesis anmd transport; Predicted virulen...	Phase 3: June 2008	3ICP	28.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP91645
(show subtarget assignments)

8

soluble

No

NP_215862

15608486

acyl-CoA dehydrogenase [Mycobacterium tu...

386

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1WS9

27.2%

Mycobacterium tuberculosis

IDP90751
(show subtarget assignments)

8

cloned

No

Cj1291c

15792614

accB

acetyl-CoA carboxylase biotin carboxyl c...

151

Predicted Essential

Community Requests

1A6X

27.2%

Campylobacter jejuni

IDP90641
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0099

15791487

birA

biotin--protein ligase [Campylobacter je...

217

Predicted Essential

Community Requests

2EAY

27.2%

Campylobacter jejuni

IDP00738
(show subtarget assignments)

1

cloned

No

SACOL0994

57284368

oppF

oligopeptide ABC transporter, ATP-bindin...

313

Drug Target Function

Phase 2: March 2008

2YZ2

27.2%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01379
(show subtarget assignments)

1

purified

No

VC0474

15640501

iron-regulated virulence regulatory prot...

298

Conserved Gene / Pathway

Phase 2: March 2008

3SZP

27.2%

Vibrio cholerae

Regulatory functions

Other

IDP90674
(show subtarget assignments)

8

cloned

No

Cj0542

15791903

hemA

glutamyl-tRNA reductase [Campylobacter j...

432

Predicted Essential

Community Requests

1GPJ

27.3%

Campylobacter jejuni

IDP02657
(show subtarget assignments)

1

cloned

No

lmo0203

16802249

mpl

Zinc metalloproteinase precursor [Lister...

510

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...

Phase 3: June 2008

1BQB

27.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02777
(show subtarget assignments)

1

soluble

No

GBAA4698

47529997

hemA

glutamyl-tRNA reductase [Bacillus anthra...

444

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

27.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02714
(show subtarget assignments)

1

purified

No

FTT1231

56708293

mesJ

PP-loop family protein [Francisella tula...

398

Conserved; Drug target functions

Phase 3: June 2008

1NI5

27.3%

Francisella tularensis

Cellular processes

Cell division

IDP01667
(show subtarget assignments)

1

expressed

No

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

Phase 3: June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01391
(show subtarget assignments)

1

cloned

No

VC0633

15640653

outer membrane protein OmpU

350

Conserved Gene / Pathway

Phase 2: March 2008

3HW9

27.3%

Vibrio cholerae

Cell envelope

Other

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05027
(show subtarget assignments)

1

purified

No

BA_0231

30253731

putative oligopeptide ABC transporter, o...

555

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

27.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01395
(show subtarget assignments)

1

purified

No

VC0704

15640723

spermidine/putrescine ABC transporter, p...

359

Conserved Gene / Pathway

Phase 2: March 2008

3TTK

27.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91965
(show subtarget assignments)

8

cloned

No

SpneCM_010100004182

298254799

pneumococcal surface protein, putative [...

292

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2WW5

27.4%

Streptococcus pneumoniae

IDP02252
(show subtarget assignments)

1

soluble

No

YPO1229

16121516

tsr2

putative methyl-accepting chemotaxis pro...

595

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

27.4%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02778
(show subtarget assignments)

1

cloned

No

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP05037
(show subtarget assignments)

1

soluble

No

BA_1836

30256106

putative polysaccharide deacetylase [Bac...

234

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C71

27.4%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02655
(show subtarget assignments)

1

cloned

No

GBAA3977

47529267

sipS-2

signal peptidase I S [Bacillus anthracis...

183

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1B12

27.4%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01993
(show subtarget assignments)

1

cloned

No

lmo1476

16803516

hemN

coproporphyrinogen III oxidase [Listeria...

385

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

27.4%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05191
(show subtarget assignments)

1

purified

No

CD0265

126697837

fleN

flagellar number regulator [Clostridium ...

292

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1HYQ

27.4%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04306
(show subtarget assignments)

8

selected

No

CAC05809

12329078

ipgE

IpgE, cytoplasmic chaperone for IpgD [Sh...

120

Shigella effector protein

Community Requests

1K3S

27.5%

Shigella flexneri

IDP90772
(show subtarget assignments)

8

soluble

No

Cj0316

15791684

pheA

chorismate mutase/prephenate dehydratase...

357

Predicted Essential

Community Requests

3MWB

27.5%

Campylobacter jejuni

IDP00529
(show subtarget assignments)

1

expressed

No

YPO2734

16122938

ccmA

putative heme exporter protein A

218

Virulence Associated Factor

Phase 2: March 2008

1B0U

27.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP91338
(show subtarget assignments)

8

expressed

No

VV2_0132

27366588

cytochrome c553 [Vibrio vulnificus CMCP6...

207

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1FCD

27.5%

Vibrio vulnificus

IDP02396
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3604

47528890

argH-1

argininosuccinate lyase [Bacillus anthra...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E9F

27.5%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP00777
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0665

57284261

iron compound ABC transporter, iron comp...

295

Conserved Gene / Pathway

Phase 2: March 2008

3EIW

27.5%

Staphylococcus aureus

Cell envelope

Other

IDP00730
(show subtarget assignments)

1

soluble

No

SACOL2453

57286449

amino acid ABC transporter, ATP-binding ...

408

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

27.5%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP92045
(show subtarget assignments)

8

selected

No

TGME49_042730

237834991

guanylate kinase, putative [Toxoplasma g...

346

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1LVG

27.5%

Toxoplasma gondii

IDP05283
(show subtarget assignments)

1

soluble

No

CD0229

126697800

flgM

negative regulator of flagellin synthesi...

91

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

27.5%

Clostridium difficile

Regulatory functions: DNA interactions

IDP90636
(show subtarget assignments)

8

purified

No

Cj0432c

15791799

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

402

Predicted Essential

Community Requests

1E0D

27.6%

Campylobacter jejuni

IDP91298
(show subtarget assignments)

8

cloned

No

STM1269

16764620

-

chorismate mutase

181

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2GBB

27.6%

Salmonella enterica

IDP01062
(show subtarget assignments)

1

cloned

No

STM3626

16766913

dppF

dipeptide transporter ATP-binding subuni...

337

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.6%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP91802
(show subtarget assignments)

8

crystallized

No

lpg0123

52840378

dsbA

thiol:disulfide interchange protein DsbA...

217

virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...

Community Requests

3L9S

27.6%

Legionella pneumophila

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02088
(show subtarget assignments)

1

cloned

No

Cj1338c

15792661

flaB

flagellin [Campylobacter jejuni subsp. j...

572

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

27.6%

Campylobacter jejuni

Cell envelope

Surface structures

IDP05143
(show subtarget assignments)

1

cloned

No

BAS4423

49187418

-

triple helix repeat-containing collagen ...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WCK

27.6%

Bacillus anthracis

Unknown function: General

IDP91789
(show subtarget assignments)

8

purified

No

TETS_LISMO

6094462

RecName: Full=Tetracycline resistance pr...

641

drug resistance / Tetracycline resistance

Community Requests

1DAR

27.6%

Listeria monocytogenes

IDP05552
(show subtarget assignments)

1

soluble

No

lmo0849

16802890

-

amidase [Listeria monocytogenes EGD-e]

616

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

27.6%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP00636
(show subtarget assignments)

1

cloned

No

SACOL1118

57285904

typA

GTP-binding protein TypA

615

Drug Target Function

Phase 2: March 2008

3E3X

27.6%

Staphylococcus aureus

Unknown function

General

IDP01893
(show subtarget assignments)

1

expressed

No

PSLT017

17233482

pefC

usher protein [Salmonella typhimurium LT...

802

Conserved; Drug target functions

Phase 3: June 2008

3RFZ

27.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP04081
(show subtarget assignments)

1

purified

No

BAS0361

49183389

DNA topoisomerase III [Bacillus anthraci...

729

Proposed to be essential proteins

Phase 4: April 2009

1D6M

27.7%

Bacillus anthracis

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02615
(show subtarget assignments)

1

expressed

No

GBAA4677

47529976

ribonuclease [Bacillus anthracis str. 'A...

458

Conserved; Drug target functions

Phase 3: June 2008

2BX2

27.7%

Bacillus anthracis

Cellular processes

Cell division

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04679
(show subtarget assignments)

1

expressed

No

GBAA2644

47527936

kinB-2

sporulation kinase B [Bacillus anthracis...

422

putative drug target function;

Phase 4: April 2009

3D36

27.7%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04455
(show subtarget assignments)

1

expressed

No

YPO1336

115347097

putative RNA methyltransferase [Yersinia...

376

conserved gene; putative drug target function;

Phase 4: April 2009

2JJQ

27.7%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP02121
(show subtarget assignments)

1

cloned

No

FTT0360

56707511

Short-chain dehydrogenase/reductase [Fra...

274

Drug Target

Phase 3: June 2008

1FDW

27.7%

Francisella tularensis

Central intermediary metabolism

Other

IDP05605
(show subtarget assignments)

1

cloned

No

BA_4978

30259470

collagen triple helix repeat domain prot...

469

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

27.7%

Bacillus anthracis

Unknown function: General

IDP02034
(show subtarget assignments)

1

cloned

No

lmo0059

16802107

hypothetical protein lmo0059 [Listeria m...

83

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

2BPS

27.7%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02489
(show subtarget assignments)

1

selected

No

GBAA3099

47528392

sipU

Signal peptidase I U [Bacillus anthracis...

183

Drug target motif; Drug target functions

Phase 3: June 2008

1T7D

27.8%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP00806
(show subtarget assignments)

1

cloned

No

SACOL1861

57284782

hsdS

type I restriction-modification enzyme, ...

399

Drug Target Function

Phase 2: March 2008

1YF2

27.8%

Staphylococcus aureus

DNA metabolism

Restriction/modification

IDP92016
(show subtarget assignments)

8

selected

No

TGME49_078830

237842577

glucose-6-phosphate dehydrogenase, putat...

878

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BH9

27.8%

Toxoplasma gondii

IDP90144
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_189.5

68449261

bifunctional IL-1-beta-inhibitor/prevent...

126

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

1G0Y

27.8%

Monkeypox virus

IDP90633
(show subtarget assignments)

8

cloned

No

VC1971

15641973

O-succinylbenzoic acid--CoA ligase [Vibr...

476

Predicted Essential

Community Requests

2QVX

27.9%

Vibrio cholerae

IDP01754
(show subtarget assignments)

1

expressed

No

CBU_0803

29541397

efflux transporter, RND family, MFP subu...

351

Conserved; Drug target functions

Phase 3: June 2008

1T5E

27.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP00092
(show subtarget assignments)

1

expressed

No

NT01SF0466

30040219

hemH

ferrochelatase

320

Essential

Phase 1: October 2007

1L8X

27.9%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90548
(show subtarget assignments)

8

cloned

No

Cj0960c

15792289

rnpA

ribonuclease P protein component [Campyl...

108

Predicted Essential

Community Requests

1A6F

27.9%

Campylobacter jejuni

IDP05023
(show subtarget assignments)

1

expressed

No

BAS2353

49185362

-

hemolysin II, C-terminal [Bacillus anthr...

240

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3ANZ

27.9%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP05751
(show subtarget assignments)

1

soluble

No

lmo0219

16802265

-

hypothetical protein lmo0219 [Listeria m...

648

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3A2K

27.9%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides

IDP91781
(show subtarget assignments)

8

purified

No

AAV80411

56155277

tetO

TetO [Enterococcus faecalis]

639

drug resistance / Tetracycline resistance

Community Requests

1DAR

27.9%

Enterococcus faecalis

IDP05651
(show subtarget assignments)

1

soluble

No

Cj1183c

6968610

cfa

guanylate kinase [Campylobacter jejuni s...

387

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1KP9

27.9%

Campylobacter jejuni

Fatty acid and phospholipid metabolism: Biosynthesis

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP90745
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1622

15792927

ribD

putative riboflavin-specific deaminase [...

336

Predicted Essential

Community Requests

2HXV

28%

Campylobacter jejuni

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP02570
(show subtarget assignments)

1

cloned

No

Cj1339c

15792662

flaA

flagellin [Campylobacter jejuni subsp. j...

572

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

28%

Campylobacter jejuni

Cell envelope

Surface structures

IDP01411
(show subtarget assignments)

1

purified

No

VC1095

15641108

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

28%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP05042
(show subtarget assignments)

1

soluble

No

BA_2921

30257513

putative sulfonate ABC transporter, sulf...

328

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X26

28%

Bacillus anthracis

Transport and binding proteins: Anions

IDP05738
(show subtarget assignments)

1

cloned

No

CD2090

126699707

putative xanthine/uracile permease [Clos...

453

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3QE7

28%

Clostridium difficile

Transport and binding proteins: Nucleosides, purines and pyrimidines

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP91260
(show subtarget assignments)

8

soluble

No

NT02SA2397

14248172

nasF

uroporphyrin-III C-methyl transferase [S...

325

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

28%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP01983
(show subtarget assignments)

0

work_stopped

No

Cj1437c

15792755

putative aminotransferase [Campylobacter...

367

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3GET

28.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04290
(show subtarget assignments)

1

cloned

No

YPO3099

218930141

manC

mannose-1-phosphate guanylyltransferase ...

470

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2CU2

28.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

IDP02463
(show subtarget assignments)

1

expressed

No

YPO1769

16122023

hpaB

4-hydroxyphenylacetate 3-monooxygenase [...

520

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2YYG

28.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP05768
(show subtarget assignments)

1

cloned

No

SACOL0553

57651385

hypothetical protein SACOL0553 [Staphylo...

431

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3A2K

28.1%

Staphylococcus aureus

Protein synthesis: tRNA and rRNA base modification

IDP01365
(show subtarget assignments)

1

purified

No

VC0201

15640231

iron(III) ABC transporter, ATP-binding p...

285

Conserved Gene / Pathway

Phase 2: March 2008

1JJ7

28.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05227
(show subtarget assignments)

1

soluble

No

lmo0541

16802584

-

hypothetical protein lmo0541 [Listeria m...

306

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3EIW

28.1%

Listeria monocytogenes

Transport and binding proteins: Cations and iron carrying compounds

IDP02073
(show subtarget assignments)

1

expressed

No

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP02691
(show subtarget assignments)

1

purified

No

FTT0943c

56708040

folB

dihydroneopterin aldolase [Francisella t...

117

Drug Target

Phase 3: June 2008

1SQL

28.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01933
(show subtarget assignments)

1

soluble

No

FTT0061

56707240

atpH

F0F1 ATP synthase subunit delta [Francis...

174

Conserved; Drug target functions

Phase 3: June 2008

2WSS

28.2%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP91228
(show subtarget assignments)

8

soluble

No

NT04EC3200

26109368

pheA

P-protein [Escherichia coli CFT073]

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

28.2%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91239
(show subtarget assignments)

8

expressed

No

HP0804

2313934

GTP cyclohydrolase II/3,4-dihydroxy-2-bu...

344

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1TKS

28.2%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP92139
(show subtarget assignments)

8

selected

No

TGME49_058030

237831459

DNA polymerase delta catalytic subunit, ...

1268

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3IAY

28.2%

Toxoplasma gondii

IDP01321
(show subtarget assignments)

1

purified

No

VC2082

15642082

zinc ABC transporter, ATP-binding protei...

262

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01153
(show subtarget assignments)

1

cloned

No

BA_5712

30260159

yycI protein

280

Conserved Gene / Pathway

Phase 2: March 2008

2O3O

28.2%

Bacillus anthracis

Cellular processes

Cell division

IDP04288
(show subtarget assignments)

1

expressed

No

YPCD1.08c

5832431

YPCD1.08c

hypothetical protein YPCD1.08c [Yersinia...

99

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

28.3%

Yersinia pestis

IDP01371
(show subtarget assignments)

1

in_crystallization_trials

No

VC0250

15640280

iron-containing alcohol dehydrogenase fa...

374

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

28.3%

Vibrio cholerae

Energy metabolism

Fermentation

IDP02361
(show subtarget assignments)

1

expressed

No

CBU_1550

29542109

ptsP

phosphoenolpyruvate-protein phosphotrans...

759

Conserved; Drug target functions

Phase 3: June 2008

2HRO

28.3%

Coxiella burnetii

Signal transduction

PTS

IDP01081
(show subtarget assignments)

1

soluble

No

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

28.4%

Salmonella enterica

Cellular processes

Detoxification

IDP90084
(show subtarget assignments)

8

soluble

No

ZP_01795673

145640079

hypothetical protein CGSHiII_00674 [Haem...

148

The protein we would like structure analyzed is from Haemophilus influenzae. Pri...

Community Requests

2XM6

28.4%

Haemophilus influenzae

IDP01944
(show subtarget assignments)

1

cloned

No

Cj1427c

15792745

putative sugar-nucleotide epimerase/dehy...

313

Known Predicted virulence-capsule biosynthesis anmd transport; Predicted virulen...

Phase 3: June 2008

3ICP

28.4%

Campylobacter jejuni

Hypothetical proteins

Conserved